Medicine

OXYGEN METABOLISM LABORATORY

Postdoc and graduate training opportunities in the HAASE group: The laboratory of Professor Volker H. Haase is seeking highly motivated postdoctoral fellows and graduate students.

The Haase lab studies hypoxia responses in physiology and pathogenesis with a focus on the PHD/HIF pathway and mitochondrial metabolism.

A successful applicant will work in a highly competitive and demanding field. Outstanding technical, and excellent oral communication and writing skills are required.

Applicants should contact Professor Haase directly by e-mail and provide a cover letter with curriculum vitae.

For more information visit the Haase Lab website: https://www.haaselab.org

Follow the Haase lab on Twitter: https://twitter.com/hifpathway

Research projects include:

a) physiologic and molecular characterization of disrupted HIF oxygen sensing and mitochondrial metabolism using mouse models,

b) oxygen-dependent regulation of erythropoiesis, cellular erythropoietin production and iron metabolism,

c) functional and molecular characterization of hypoxia responses in cellular metabolism and tissue injury responses,

d) in vitro and in vivo investigations of hypoxic signaling pathways in acute and chronic kidney injury and renal cancer,

e) single cell RNA seq to characterize hypoxia responses in individual renal cells and renal cancer cells,

f) in vitro and in vivo studies of mitochondrial function in renal disease, polycystic kidney disease and renal cell cancer,

g) HIF-prolyl hydroxylase inhibitors in renal physiology. Rotation students will participate in ongoing projects and will be exposed to a broad spectrum of molecular techniques, as well as in vivo work.

Medicine

The Vanderbilt Genetics Institute (VGI) at Vanderbilt University School of Medicine was established to foster scientific interactions at the clinical, molecular, and analytical levels by providing state-of-the-art resources to Vanderbilt scientists involved in genetic and genomic research. VGI is led by Professor, Nancy Cox, who is the Mary Phillips Edmonds Gray Professor of Genetics. VGI is uniquely positioned to enable translational discoveries due to the enormous university-wide investments in biomedical informatics and precision medicine. These investments are exemplified by BioVU, a biobank of genetic material containing over 285k patient samples and Vanderbilt’s lead role in the President’s Precision Medicine Initiative and now All-of-US. Our school is committed to the principles of equal opportunity for employment.

We are seeking for applicants for the Postdoctoral Research Fellowship at the Vanderbilt Genetics Institute. We are embedded in VGI (headed by Prof. Cox) and focuses on studies of the genetic architecture of cardiometabolic diseases, especially the metabolic parts of these diseases and traits. This postdoctoral fellow will be jointly supervised by Drs. Lu and Cox. Dr. Lu is currently supported by several ongoing NIH R01 grants (R56HL150186, R01HL158884, and DK135938). We collaborate extensively with national and international consortia. Projects include genome-wide associations and whole exome/genome sequencing studies.

The successful candidate will have opportunity to work on large-scale consortium datasets, and the EHR-linked Vanderbilt Biobank (BioVU). He/she will work in a team environment. He/she will apply existing genetics, statistics and bioinformatics tool. A primary role will be contributing to the design, implementation, manuscript preparation of research projects and assist grant writing. He/she will be responsible for analyzing/summarizing large-scale genetic data on cardiometabolic traits and diseases for publications. He/she must demonstrate the relevant experience with the first-author papers/manuscripts.

Applicants must hold a PhD degree in genetics, epidemiology, statistical genetics, bioinformatics, biostatistics, computer science or related fields. Statistical and programming skill such as R and the use of UNIX/LINUX is required. Experience in genetic and bioinformatics data analysis is desirable.

Application address: Applicants could contact Yingchang (Kevin) Lu for more information: kevin.lu@vumc.org.

Medicine

We are recruiting a second post-doc fellow to work on a grant funded by the American Society of Hematology that aims to evaluate the effectiveness and safety of anticoagulants. The position is available immediately.

QUALIFICATIONS

§ PhD, ScD, MD, or PharmD with expertise in pharmacoepidemiology, health outcomes research, epidemiology, biostatistics, public health, or related field.

§ Understanding of epidemiology methods, study design, and data analysis.

§ Expertise with statistical software such as SAS.

§ Experience with claim databases such as MarketScan, Optum, Medicaid, or Medicare § Strong communication and analytical skills.

Interested applicants should send a curriculum vitae and a cover letter to:

Ghadeer K. Dawwas, PhD, MSc, MBA

Assistant Professor of Medicine

Division of Epidemiology

Vanderbilt University School of Medicine

Ghadeer.Dawwas@vumc.org

Medicine

POST-DOCTORAL RESEARCH FELLOWSHIP IN PHARMACOEPIDEMIOLOGY, COMPARATIVE EFFECTIVENESS AND SAFETY RESEARCH, AND REAL-WORLD EVIDENCE

The Pharmacoepidemiology research group housed within VUMC Division of Epidemiology is looking for a highly motivated postdoctoral fellow to lead research projects funded by the National Institutes of Health focusing on evaluating the comparative effectiveness and safety of therapeutic alternatives using real-world data. The Fellow will work with a multidisciplinary research team and be mentored by Ghadeer Dawwas, PhD, MSc, MBA, Assistant Professor of Medicine: https://medicine.vumc.org/department-directory/Ghadeer-Dawwas. Fellowship start dates are flexible. The Fellow will be encouraged to lead their own research projects, write grants, communicate results at national and international conferences, and publish scientific findings. The division of pharmacoepidemiology places career mentoring as one of their top priorities and will provide the fellow with ample of opportunities for professional growth within and outside VUMC.

QUALIFICATIONS

* PhD, ScD, MD, or PharmD with expertise in pharmacoepidemiology, health outcomes research, epidemiology, biostatistics, public health, or related field.

* Understanding of epidemiology methods, study design, and data analysis.

* Expertise with statistical software such as SAS or R.

* Experience with claim databases such as MarketScan, Optum, Medicaid, or Medicare

* Strong communication and analytical skills.

Please direct inquiries to Ghadeer.Dawwas@vumc.org. Applicants will be notified with the outcome after reviewing their application. Interested applicants should send a curriculum vitae and a cover letter to:

Ghadeer K. Dawwas, Ph.D., MSc, MBA

Assistant Professor of Medicine

Division of Epidemiology

Vanderbilt University School of Medicine 

Ghadeer.Dawwas@vumc.org

Medicine

Postdoctoral Fellow – Cancer Microbiome

We have an immediate opening for a postdoctoral fellowship in the Markham Lab. The project opportunities extend from recent work identifying C. difficile as a component of the human colorectal cancer microenvironment. (Drewes, Chen, Markham, et al. 2022 Cancer Discovery). Our investigations examine the role of C. difficile toxins using mouse models of colonic neoplasia and human 3D organoids. Individuals with expertise in mouse modeling, tissue culture, and high-resolution microscopy are particularly desired. Familiarity with modern methods of high-dimensional computational analysis for multiplex spatial data is desirable. Experience working in teams and the ability to apply independent management skills are important. Long-term funding is secure, along with a highly competitive salary and fringe benefits. Those interested should send a CV and cover letter to Nick Markham (nick.markham@vumc.org).

Medicine

The laboratory of Jennifer Pietenpol and Brian Lehmann at Vanderbilt University Medical Center is seeking a highly motivated postdoctoral candidate to study epigenetic mechanisms of tumor immune cell escape. The lab is focused on translational breast cancer research that advances treatment strategies for triple-negative breast cancer. The successful candidate will engage productively on a project defining novel mechanisms of immune cell evasion by cancer cells. The candidate will utilize cell culture, syngeneic animal models, human tissues and data science to advance our understanding of tumor immune suppression and develop pre-clinical data for future clinical trials for breast cancer.

Please visit the lab website for more information: https://www.vumc.org/pietenpol-lab/welcome  

The laboratory welcomes candidates to apply who will be receiving shortly or have recently received a Ph.D. in molecular biology, cancer biology, immunology or a related field. The candidate is expected to plan, design, and conduct highly technical and complex research projects independently and in consultation with the Principal Investigators, analyze research data and provide interpretations and contribute to the development of research documentation for publication. Vanderbilt University Medical Center offers a highly collaborative research environment, that has as its first pillar the people who form the team - “We nurture a caring, culturally sensitive, and professional atmosphere as we continuously invest in the well-being and aspirations of our people.” Ideal candidates will be self-motivated and have strong interpersonal and communication skills and experience in cell biology, molecular biology, data science and basic immunology techniques involving mouse models.

Please send your application with a cover letter stating research interests and career goals, full CV, and contact information for three references to Brian Lehmann, Ph.D. (brian.d.lehmann@vumc.org)  

Medicine

Postdoctoral position available in the Wilson Lab in the Vanderbilt Center for Mucosal Inflammation and Cancer, Directed by Dr. Wilson. Please email Dr. Wilson if interested: keith.wilson@vanderbilt.edu.

There are opportunities to study mucosal immunology, inflammation, and carcinogenesis. Expertise in molecular biology, immunology, microbiology, and/or biochemistry is highly desirable. Candidates with an interest in host-pathogen interactions in the gut can develop those interests in the Wilson Lab. There are opportunities to conduct research using rodent and in vitro models, and translational studies, especially working with organoids from stomach and colon, as well as multi-comics.

Medicine

Two post-doctoral positions are available immediately in molecular/genetic cancer epidemiology program at Vanderbilt University Medical Center (VUMC), Nashville, TN. The postdoctoral fellows will work with a multidisciplinary team spanning molecular epidemiology, genetics, genomics, and bioinformatics to evaluate potential functions of genes, DNA methylation alterations, and genetic variants identified by transcriptome-wide association studies (TWAS) and methylation-wide association studies (MeWAS). Using wet lab in vitro assays, functional genomics, and bioinformatics approaches, we aim to evaluate how these genes, methylation alterations, and genetic variants are related to the risk of breast, lung, and colorectal cancers. The projects are sponsored by several NCI-funded R01 grants. Eligible applicants should have a Ph.D. or related degree in biology, genetics, bioinformatics, or related field. Ideal candidates would have training and experience in cancer biology, molecular genetics, and molecular biology. Individuals with experience in common molecular techniques including but not limited to cell-based assays, cloning, qPCR, and gel electrophoresis, are preferred. Qualified candidates can also apply for the Molecular and Genetic Epidemiology of Cancer (MAGEC) postdoctoral trainee program funded through an NCI T32 training grant (https://www.vumc.org/magec/). Salary is commensurate with experience and follows the NIH guidelines for postdoctoral salaries. VUMC is an Equal Opportunity employer and prides itself on its commitment to diversity. Nashville, the state capital, is the largest metropolitan area in Tennessee, with temperate climate, affordable residential areas, vibrant cultural activities and abundant recreational opportunities. To apply, please email a cover letter and CV to Dr. Qiuyin Cai at qiuyin.cai@vanderbilt.edu.

Medicine

We have an opening for a postdoctoral fellow - we welcome those with a background in cell biology, physiology, engineering, genetics, or informatics.

Medicine

NIH funded postdoctoral positions are available for research in developing cell and gene therapies for kidney diseases. Individuals with a strong background in molecular biology, cell culture, and a willingness to work with animals are encouraged to apply. The researcher will learn a variety of novel techniques for in vivo and ex vivo gene transfer including transposon technology, CRISPR/Cas9, and adeno-associated viral (AAV) vectors. Current projects are focused on developing a cell therapy for Fabry disease, engineering new AAV vectors, and advancing non-viral genome engineering and gene delivery technologies.

Interested applicants can contact Dr. Wilson directly for consideration at matthew.wilson@vumc.org

Medicine

Seeking someone with a PhD in an aspect of Physiology, Cell, or Molecular Biology. The applicant should have experience with mouse models and tissue culture. Developmental biology background and microscopy experience helpful, but not required. There are two projects with which the individual would be involved. One project involves using genetic mouse models to examine the interaction of two key transcription factors in setting up a permissive transcriptional landscape to establish the endocrine lineage in pancreas development. The other involves manipulation of prostaglandin receptors activity in beta cells to promote beta cell proliferation and survival.

Medicine

A postdoctoral position is open for study on tumor cell metabolism and anti-tumor immunity. Recent PhDs are encouraged to apply. For those candidates with more than 5 years of postdoctoral experiences, Research Instructor or Research Assistant Professor positions will also be considered.

Please send CV and contact information of references to: Jin Chen, M.D., Ph.D., Professor of Medicine and Cell & Developmental Biology, Director of Graduate Studies in Cancer Biology. email: jin.chen@vumc.org

Medicine

Research fellow—Molecular Epidemiology (focusing on metabolomics or gut microbiome)

We are seeking applications from strong candidates for a research fellow position in the Division of Epidemiology at Vanderbilt University Medical Center. The successful applicant will work on NIH-funded projects that apply multi-omics approaches in epidemiologic studies, e.g., metabolomics and metagenomics, to examine the role of diet, lifestyles, gut microbiota, and microbiota-host interactions in metabolic diseases. The successful applicant will work with a multi-disciplinary research team to perform high-dimensional omics data analysis and statistical analysis, write manuscripts, and present research findings. 

We are seeking a highly motivated individual with excellent analytical, statistical programming, writing, and collaboration skills. Experience in metabolomic or metagenomic data analysis is desirable. Please contact Dr. Danxia Yu (danxia.yu@vumc.org) with a cover letter, curriculum vitae, and reference letter or contact information for three professional references.

Medicine

The Center for Asthma Research (CAR) seeks applications for a postdoctoral position at Vanderbilt University School of Medicine for a post-doctoral fellow with a focused interest in clinical epidemiology, translational science or systems biology with a relevant degree and experience to work in the area of developmental origins of childhood asthma and allergic diseases.

The post-doctoral fellow will join a highly multidisciplinary research team led by Tina Hartert, M.D., M.P.H.. Dr. Hartert is Professor of Medicine and Pediatrics, the Director of the CAR, and serves as the Assistant Vice President for Translational Science at Vanderbilt University Medical Center. CAR consists of nearly 40 members across a wide range of disciplines and has established collaborations with investigative teams throughout the United States and worldwide. Dr. Hartert is the principal investigator of one of the largest number of cohorts assembled to study asthma and allergic disease development, the resources of which are available for post-doctoral fellow research projects. Post-doctoral fellowships are for three years, and most post-doctoral fellows are supported by our NIH T32. We are seeking a highly motivated individual with a doctoral degree (Ph.D., M.D./Ph.D. or equivalent) in a relevant area (epidemiology, quantitative or systems biology, biostatistics, bioinformatics, health services research, pediatrics, etc.). Strong communication, analytical skills and experience manipulating and analyzing large complex databases is desired, and experience with high-dimensional data (genetic, metabolomics, microbiome, or other ‘omics’) would be an asset. Having a proactive and flexible demeanor with an ability to effectively work in a team environment is important.

Interested applicants should submit their CV and a brief statement of research interests and accomplishments by email to:  Tina Hartert, MD, MPH, Professor of Medicine and Pediatrics, tina.hartert@vumc.org.

Vanderbilt University is one of America’s premier private universities and ranked Fortune's "100 Best Companies to Work For," and Nashville, Tennessee is among Business Week’s top 15 “America’s Best Cities”. Vanderbilt University support and infrastructure for post-doctoral fellows is unparalleled, and our post-doctoral fellows go on to have highly successful careers. Vanderbilt University Medical Center and the Monroe Carell Jr. Children’s Hospital at Vanderbilt are recognized annually as one of “America’s Best Hospitals” compiled by U.S. News & World Report. Dr. Hartert has a long history of successful mentoring and has received numerous awards for her mentoring of post-doctoral fellows.

Tina Hartert : tina.hartert@vumc.org : (615) 936-1010

Medicine

Greetings! My Lab has an open postdoc position to study how signaling molecules generated in chromatin alter histone acetylation and gene expression.

We recently discovered a new gene regulatory mechanism in human cell lines. This new mechanism revolves around a kinase our lab studies, which generates inositide signaling molecules. We discovered this kinase is recruited to thousands of transcriptional start sites, regulating gene expression in a kinase-dependent manner and altering histone acetylation and methylation. You will be finishing up these studies and building further on them.

The ideal candidate will need to have an interest in helping others in the lab and have skills in mammalian cellular biochemistry, gene expression analysis and/or genomics. Experience with or eagerness to learn ChIP, RNA-seq, ATAC-seq, qPCR or other gene expression analyses is ideal.

If you're doubting your fit, I encourage you to email and ask! I have many other projects in structural biology, genomics and drug design/screening you might be a great fit for... If you don't ask, you don't get!

Please email a cover letter with your CV to ray.blind@vanderbilt.edu and we can take it from there! Thank you!

Ray

Medicine

We are looking for postdoctoral candidates to participate in basic studies controlling epithelial polarity as well as more translational efforts to develop innovative therapeutic approaches for colorectal cancer.

Available projects include:

- Regulation of EGFR signaling by polarized trafficking of its ligand epiregulin and mechanisms underlying transformation upon apical mistrafficking of epiregulin;

- Role of receptor tyrosine kinases MET and RON in resistance to EGFR-targeted therapeutics in colorectal cancer.

Please send CV and a cover letter to bhuminder.singh@vumc.org

Thank you

Bhumi

Medicine

Cardiovascular Post-Doctoral Clinical Research Fellow:

We are seeking a Post-Doctoral Clinical Research Fellow to assist with an exciting, NIH funded Cardiovascular research project that will include event adjudication with modern criteria for acute myocardial infarction (MI) subtypes (i.e., type 1 versus type 2 MI), as well as accounting for all non-ischemic myocardial injury events. Despite different prevalence, pathobiology, and prognosis, all NHLBI prospective cohorts adjudicate incident acute myocardial infarction (MI) as a singular entity, as opposed to etiologically distinct MI subtypes defined by the 4th Universal Definition of MI. By adjudicating specific MI phenotypes, and defining their epidemiology, this project will directly enable more precise risk prediction, discovery of novel pathobiology-specific risk factors, and allow for the development more targeted preventive strategies (i.e., anticoagulation for those at risk for type 1 versus type 2 MI). This position will include close collaboration with the Multi-ethnic Study of Atherosclerosis (MESA), a National Institutes of Health research cohort.

The Post-Doctoral Clinical Research Fellow will be integral to myocardial injury adjudication skill acquisition and coordination of effort between study adjudicators, study advisory board, the study Program Coordinator, MESA Data Coordinating Center, MESA Proposals and Publications Committee, MESA Field Centers, statisticians, and co-investigators. The fellow will develop expertise in myocardial injury, multi-center cohort research and opportunities for independent projects will be encouraged. Minimum requirements will include a medical degree, and formal training in epidemiology/statistics, preferably a Master of Public Health or Master of Science and Clinical Research degree. Prior clinical training (residency) will be preferred. Additional course work will be encouraged to enhance the fellow’s career goal of maturing into an independently funded myocardial injury/acute MI translational researcher. The fellow will be located at Vanderbilt University in Dr. DeFilippis’ laboratory, where s/he will have office space, a computer, and administrative support. This position requires someone with excellent interpersonal and communication skills.

Please email cover letter and CV to Andrew DeFilippis, MD, MSc at andrew.defilippis@vumc.org

Medicine

The Serezani lab at Vanderbilt University Medical Center is looking to recruit a postdoctoral associate to work on different NIH-funded projects. Dr. Serezani is also a member of many institutional NIH T32 Training Grant that could provide multi-year support for postdoctoral trainees (USA citizens and Permanent Residents).

Our lab is interested in understanding how phagocyte's intracellular brakes influence host defense in systemic and localized infections. More specifically, we want to investigate:

1) Host-derived factors that account for enhanced susceptibility to infections in preexisting conditions. Using the in vivo imaging system (IVIS) and intravital microscopy, we are dissecting the dynamics of different monocyte, macrophage, and neutrophil populations in the skin and lung. We have been investigating how ingestion of dead cells (efferocytosis) influences metabolic reprogramming in diabetes, obesity, and aging. Another lab project aims to assess the role of microRNAs (mainly miR21) in neutrophil function during skin host defense.

2) Identification and actions of pleiotropic intracellular inhibitors during sepsis. We have been interested in identifying intracellular events that could decrease systemic inflammatory response during sepsis. We have been focusing on understanding the cellular and molecular targets of phosphatases (PTEN and SHP1) and suppressor of cytokine signaling (SOCS) in neutrophils and macrophages during sepsis. We are identifying new regulatory programs triggered by PTEN and SOCS1 in inflammasome assembly and fatty acid oxidation that influences organ damage and mortality in sepsis.

The projects will be tailored to meet the individual qualifications and interests of the candidate. For example, the nature and extent of advanced microscopy and bioinformatics or a focus on different animal infection models can be discussed with the applicant.

Qualifications • Suitable applicants should have a recent Ph.D. in immunology or a related field, a record of productivity, and excellent communication skills. • The ideal candidate will work well in an interactive scientific environment, be intellectually curious, and have experience in all aspects of immunology. • Research experience in immunology, cell biology, and/or microbiology • Critical skills include¿extensive experience with animal handling, hands-on experience with, and extensive knowledge of tissue culture (including isolation of primary cells), basic molecular biology techniques, and basic fluorescent microscopy • Proven track record of troubleshooting and problem-solving. • Strong organizational skills with the ability to balance multiple projects in a fast-paced environment and bring projects to completion. • Willingness to learning bioinformatics to perform metabolomics, lipidomics, and RNAseq analysis • Interested in learning advanced microscopy, such as super-resolution microscopy, high-resolution live-cell imaging, and intravital microscopy. • Proven track record of troubleshooting and problem-solving. • Strong organizational skills with the ability to balance multiple projects in a fast-paced environment and bring projects to completion. • Helpful Nature – Offers to help lighten the load for others in times of need; volunteers rather than waiting to be asked; understands that almost no one works in a silo and needs the help of others to do their job well; recognizes that by helping others first, others will likely reciprocate Principal Responsibilities • Spearhead projects investigating the role of phosphatases in the metabolism control of epigenetics and inflammatory response • Independently design and conduct experiments under the supervision of the Principal Investigator. • Conduct literature reviews to be used in determining the most suitable research methods. • Present data in lab meetings (~1 x month),

  Candidate must be available to start working immediately or a later start date can be discussed. Highly motivated individuals should submit a single PDF file containing CV, a brief description of research interests and experience, and the names of 2-3 references to h.serezan@vumc.org

Medicine

The Brown Laboratory is seeking a highly motivated candidate for a Postdoctoral Research Fellowship who will study chromatin-dependent gene regulation in cardiovascular and metabolic disease.  For more details about current laboratory projects or open positions, please visit the Brown laboratory website: jonbrownlab.com.

Medicine

The Zinkel Lab in the Department of Medicine at Vanderbilt University School of Medicine is seeking a highly-motivated individual to join our team. Our lab studies how inflammation in the bone marrow microenvironment impacts blood diseases such as clonal hematopoiesis, bone marrow failure (myelodysplastic syndrome (MDS) and leukemia and how inhibiting inflammation impacts disease. We use single cell analysis of mouse models and human samples as well as studies in BioVU (in collaboration with Eric Gamazon) to determine gene pathways that predispose to progression to disease. The successful candidate will have a PhD and/or MD with experience in molecular and cellular biology and a solid publication record. Vanderbilt offers a highly collaborative research environment focused on interdisciplinary research. Please send a curriculum vita, the names of three references, and a letter describing your research interests to: Dr. Sandra Zinkel (Sandra.zinkel@VUMC.org)

Medicine

A postdoctoral position is available for eligible candidates with training in genetics, programming, machine learning, data science and statistics. Our laboratory focuses on epidemiologic and genomic studies of cardiovascular traits. The approaches we use include epidemiologic methods including regression analyses and genome and exome-wide association studies using high-density SNP arrays (common variants as well as rare variants), whole exome/genome sequencing in families with cardiovascular disease, Phenome wide association studies (PheWAS), variant annotation and electronic phenotyping algorithms. Our laboratory is part of a multi-project American Heart Association funded Strategically Focused Vascular Research Network with an emphasis on the clinical and genetic determinants of peripheral artery disease, microvascular disease, and major adverse limb outcomes. The candidate should be able to analyze such data and have a Ph.D., M.D., or equivalent doctoral degree in biostatistics, statistics/statistical genetics or data science. The candidate is expected to gain cross-disciplinary training in statistical genetics, genetic epidemiology, epidemiology, bioinformatics and translational genomics. The post-doctoral fellow will contribute to other projects within the research network and take a leadership role on peer-reviewed publications and presentation of results at appropriate national meetings. In addition, they will also be given opportunities to develop their own project and encouraged to apply for independent funding.

Funding is available for one position lasting two years with an anticipated start date of July1, 2020. Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellowship is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at VUMC or elsewhere. Please attach the following required documents at the time of application:

    1. Current curriculum vitae and bibliography

    2. Three letters of recommendation, signed, on letterhead, describing:

        o Relationship to the applicant.

        o Past work/academic performance.

        o Work qualities/personal conduct.

        o Overall assessment of potential for success in research environment.

    3. Doctoral degree certification, if applicable: o Original or notarized copy of diploma or final transcript issued by school (English translation required).

Medicine

The Nashville VA Quality Scholars Program (http://www.vaqs.org/nashville/) is accepting applications for the position of post-doctoral scholars in clinical psychology. The Nashville program is part of the National VA Quality Scholars (VAQS) Program (http://www.vaqs.org), which develops leaders and scholars to improve healthcare. VAQS provides an interprofessional fellowship in healthcare quality improvement for physicians, doctoral-trained nurses, pharmacists, clinical psychologists and other health professionals.

Post-Doctoral Training: In this dedicated two-year fellowship, the VAQS program offers scholars opportunities to become leaders with knowledge and skills to:

• Improve health care delivery, health systems organization and management, and health professions education through interventions that exert positive influences in each domain

• Apply the knowledge and methods of health care quality improvement to the care of individual patients and populations

• Teach health professionals about healthcare improvement

• Perform research and develop new knowledge for the ongoing improvement of the quality and value of healthcare services.

The Nashville VAQS Program is known for its robust research and quality improvement programs and close collaborations with Vanderbilt University and its vast array of resources. We leverage resources within our VA, across the VA nationally, and those available through our academic affiliate (Vanderbilt), including the Institute for Medicine and Public Health, the Center for Health Services Research, the Center for Clinical Quality and Implementation Research, the Center for Health Behavior and Health Education, the Department of Biomedical Informatics, the Vanderbilt Epidemiology Center, the Center for Surgical Quality and Outcomes Research, the Center for Quality Aging, the Schools of Management and Education, and the nationally recognized Precision Medicine Initiative and Population Health Initiative, among many others.

Faculty at the Nashville VA Quality Scholars site are sought after for their breadth and depth of experience in quality improvement, implementation science, health services research, clinical epidemiology and outcomes research, health behavior, and clinical informatics. Our faculty strive to generate the evidence-basis for the content, processes and structures of clinical care, and designing and implementing transformational change across a wide variety of clinical specialties. There is integration and collaboration across other disciplines to advance population health. In addition, faculty within the Vanderbilt Psychology Department and licensed PhD Clinical Psychologists working clinically either at the VA or Vanderbilt are available to mentor and supervise clinical psychology fellows.

To Apply: Please refer to website (http://www.vaqs.org/nashville/) and email Sandra.Simmons@vumc.org or any of the other Senior Scholars.

Medicine

The Kim lab (KIM LAB AT VUMC-HEM/ONC) is in the division of Hematology/Oncology, the department of Medicine at Vanderbilt University Medical Center. The Kim lab is also affiliated with Vanderbilt Center for Immunobiology (VCI) and Vanderbilt Institute for Infection, Immunology and Inflammation (VI4). Dr. Kim (PI) is a physician who treats leukemia/lymphoma/myeloma patients using chemotherapy and stem cell transplantation. Dr. Kim is also an immunologist who is interested in tumor immunology and transplant immunology. He received a research training in Lieping Chen lab at Yale University.  We are looking for enthusiastic students and post-doctoral fellows.

The major focus of the laboratory includes

1. Overcoming immune evasion in leukemia: Recently, immune checkpoint blockades, including anti-programmed cell death protein 1 (PD-1) therapy, have shown unprecedented clinical efficacy in some solid tumors. However, the response rate to immune checkpoint blockades in myeloid leukemia has been disappointing. The failure of anti-PD-1 therapy in myeloid leukemia suggests that immune evasion in A myeloid leukemia may be attributed to the expression of unique co-inhibitory molecules outside the PD-1–PD ligand 1 (PD-L1) axis. We are investigating to find novel relevant co-inhibitory molecules besides PD-1¬–PD-L1 in human myeloid leukemia and study the role of those co-inhibitory molecules in mouse models including humanized mice.

2. Dissect graft-versus-host disease and graft-versus-leukemia in allogeneic stem cell transplantation (allo-SCT) by manipulating co-inhibitory molecules: Allo-SCT represented the earliest successful immunotherapeutic strategy in AML, employing graft-versus-leukemia (GVL; the attack of donor-derived T cells on leukemic cells). But GVL treatment is generally accompanied by the increased risk of graft-versus-host disease (GVHD; the attack of healthy recipient tissues by donor T cells), as both GVL and GVHD are caused by similar allogeneic T cell responses. In addition, our current immunosuppressive strategies (e.g., corticosteroids) are indiscriminate, so we cannot selectively inhibit GVHD while maintaining GVL effects. Non-selective pharmacologic inhibition can increase the risk of opportunistic infections due to delayed immune reconstitution and may mitigate GVL effects. To overcome this issue, selective inhibition of allo-reactive T cells to suppress GVHD while maintaining GVL and pathogen-specific immunity has been investigated. We are investigating strategies to selectively inhibit GVHD with sparing GVL in allo-SCT by manipulating co-inhibitory molecules.

3. Human correlative studies in line with clinical trials: we participate in human correlative studies with samples from patients in clinical trials. Typically we perform a CyTOF, a multi-color flow cytometry, a multiplex immunofluorescence, ex vivo T cell suppression/activation assay.

Medicine

Postdoctoral Research fellowship

Center for Matrix Biology - Division of Nephrology

Vanderbilt University Medical Center, Nashville TN

Job Description

A NIH-funded postdoctoral fellowship is available immediately in the laboratory of Dr. Roberto Vanacore to investigate molecular mechanisms of renal fibrosis in chronic kidney disease. We use animal models in combination of cutting-edge technologies in proteomics/mass spectrometry, biochemistry and molecular/cell biology to investigate the structure-function relationship of collagen and its modifying enzymes on the biosynthesis, assembly and function of the renal extracellular matrix. Consistent with our laboratory efforts to identify novel potential therapies for renal disease, the candidate will have the opportunity to pursue translational research in collaboration with pharmaceutical companies by testing novel compounds designed to inhibit the development and progression of kidney fibrosis. The Vanacore Lab is housed in the Division of Nephrology and is part of the Vanderbilt Center for Kidney Disease and Center for Matrix Biology.

Candidate Skills

We are seeking a highly motivated recent PhD graduate with experience in protein biochemistry and molecular/cell biology. The ideal candidate will be proficient in the design, cloning, purification and functional characterization of recombinant enzymes. A desire to deepen proficiency in protein biochemistry by learning mass spectrometry/proteomics will be a good fit as our Lab can provide excellent training opportunities in a great environment. Mouse work experience is preferred, although not a requirement as the laboratory can provide training to models of renal disease. Ability to think and work independently as well as a creative and critical mindset are key features for a successful candidate. Excellent oral and written communication skills and the ability to work as a team member are essential. Participation in grant and manuscript writing is expected. Preference will be given to individuals pursuing an academic career with a strong desire to drive projects to completion and publish as a lead author.

Requirements and Benefits

This is a full-time position that requires a PhD degree (Biochemistry, Molecular/Cell Biology, or related discipline). Salary is based on NIH pay scale starting from $50,004. Vanderbilt also offers an excellent benefits package including a retirement plan, health and dental insurance, etc. More information about postdoctoral positions, available resources and relocation to Nashville, TN can be found at the BRET office (https://medschool.vanderbilt.edu/postdoc/)

Please submit a cover letter describing previous professional experiences, a summary of your current work, future plans and expectations. When listing publications please include a brief summary of your role and contributions to the study. The letter, CV and contact information for at least 3 references should be sent to roberto.vanacore@vanderbilt.edu.

Medicine

An immediate opening for a postdoctoral position exists at Vanderbilt University School of Medicine. The project is to examine the role of stem cells in metastasis using orthotopic mouse models of colon cancer with unique reporters embedded. Individuals with experience in mouse models, colonoscopy, lineage mapping, and immunofluorescence microscopy are encouraged to apply. The Lau lab collaborates closely with the Coffey lab, and the individual will be immersed in an interdisciplinary environment with training opportunities in single-cell resolution multiplex immunofluorescence, smFISH, and single-cell RNA-seq, organoids, and computational data science techniques. Funding is secure, along with a highly competitive salary and fringe benefits. Those interested should send a CV and cover letter to  Ken Lau at ken.s.lau@vanderbilt.edu.

Medicine

The laboratory of Dr. Lauren E. Woodard in the Department of Medicine, Division of Nephrology and Hypertension at Vanderbilt University Medical Center in Nashville, TN is currently accepting applications for a Postdoctoral Fellow position. The applicant must have, or be nearing completion of, a Ph.D., M.D., M.D./Ph.D. or equivalent. The successful candidate will work in a highly collaborative environment to conceive experiments, conduct research, and analyze data. It is expected that the successful candidate will travel to and present at conferences, write and edit manuscripts, and carry out multiple projects independently. Our lab has expertise in gene therapy, transposon biology, molecular biology, gene transfer, stem cells, cell therapy, mouse models, kidney injury, renal disease, Cas9, genome modification and transcription factor reprogramming. Candidates with experience in animal trauma models, organoids, entomology, insect tissue culture, bioengineering, synthetic biology, or protein aggregation should mention this in their cover letter. Outstanding applicants are invited to apply regardless of prior research area. Further information may be found here (https://labnodes.vanderbilt.edu/member/profile/id/12496). Please send a CV, list of three references, and a cover letter narrative summarizing relevant experience and career goals to: lauren.woodard@vumc.org. Vanderbilt University Medical Center is an Equal Opportunity Employer.

Medicine

Postdoctoral opportunities in Leukemia and Bone Marrow Inflammation:

Position: The Ferrell Lab (https://medsites.mc.vanderbilt.edu/ferrelllab) is seeking a highly skilled, motivated and energetic post-doctoral fellow to conduct disease-focused research in myelodysplastic syndromes, acute myeloid leukemia and bone marrow immunology/inflammation. The position comes with competitive salary and excellent potential for career development. 

Requirements: Qualified candidates should have strong fund of knowledge in cancer biology and/or immunology and have experience in several (but not all) of the following areas: single cell experimentation and data analysis (e.g., RNAseq, CyTOF), computational biology (including experience with R), in vitro immunology assays, and xenograft models of primary human leukemia. The qualified applicant should have a doctoral degree in biomedical science (PhD or MD/PhD), a strong publication record (primary peer-reviewed publications) and excellent writing/communication skills. Successful applicants will have opportunity to tailor project related to above to individual interests and skills.

Environment: Candidates will receive focused and personalized mentoring from the PI, the Division of Hematology/Oncology, and the School of Medicine. Vanderbilt University Medical Center is a large, collaborative environment for biomedical research with many opportunities for career development, funding, and education for postdoctoral researchers. Our lab is a member of the renowned Vanderbilt-Ingram Cancer Center, which brings together clinicians, basic scientists, engineers and statisticians in close collaboration due to its interdisciplinary research and close physical proximity. The PI also conducts early phase clinical trials for AML and MDS which serve as a source of patient samples and collaborative studies.

Interested applicants should contact the PI at: brent.ferrell at vumc.org.

Medicine

Postdoctoral position for single-cell genomics project

We are seeking a highly motivated, enthusiastic and independent postdoctoral fellow to join our multidisciplinary laboratory ground studying the genetics and molecular mechanisms of pulmonary fibrosis. Our work utilizes single-cell genomic technologies, genetic and genomic approaches, transgenic animal modeling, in-vitro and primary cell culture techniques to study mechanisms of disease initiation and propagation. Applicants should have a PhD or MD/PhD degree with a background in Computational Biology, Human Genetics, Cell/Molecular Biology, or a related field. Successful applicants will have strong prior experience with cell and molecular biology; computational experience is preferred but not required. Interested applicants should send a current CV and a brief statement of interest to Jon Kropski, jon.kropski@vanderbilt.edu.

Medicine

Postdoctoral Research Fellowship Available

Clostridium difficile Host-Microbe Interactions & Translational Research Fellowship 

Where: The Aronoff Lab, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Start date: immediately

The Aronoff Lab in the Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, is seeking candidates for a Postdoctoral Research Fellowship in Infectious Diseases to join a team studying clinical and translational aspects of Clostridium difficile infection. Our lab focuses on host-microbial interactions in the context of serious Gram positive bacterial infections.

Training opportunities will be related to: animal models of C. difficile infection, clinical pharmacology, mucosal immunology and microbiology as well as building experience in the conduct of large human clinical trial.

Job requirements will include working with human research subjects, assisting with some mouse handling and infection and conducting bench-top assays related to bacterial pathogenesis and immune responses.

The appropriate candidate will have a PhD or MD (or both) and experience in bacterial pathogenesis and/or intestinal mucosal immunology. Preference will be given to individuals with experience in clostridial microbiology or host-microbe interactions. Strong organizational skills are a must. Candidates must be self-motivated, able to write scientific manuscripts and proposals well and have a track record of strong productivity. Postdoctoral fellows will be expected to be able to function well in team science and in mentoring graduate students.

The Vanderbilt University Medical Center is an equal opportunities employer.

Interested applicants are requested to mail their CV, a one-page personal statement, and two letters of recommendation with reference phone numbers and email addresses to: David M. Aronoff, MD, d.aronoff@vanderbilt.edu

Medicine

An immediate opening for a postdoctoral position exists in the Coffey lab at Vanderbilt. Individuals with expertise in mouse genetics and confocal imaging/high resolution microscopy are particularly desired. The project is to examine the role of tumor-initiating cells in mouse models of colonic neoplasia using unique reporter mice generated in the lab. Familiarity with modern methods for precise lineage-tracing, as well as examining high-dimensional data with multiplex immunofluorescence, smFISH, and single-cell RNA-seq, are desirable. Experience working in small teams and the ability to apply leadership and independent management skills are important. Long-term funding is secure through Dr. Coffey’s NCI outstanding investigator award, along with a highly competitive salary and fringe benefits.

Those interested should contact Bob Coffey at robert.coffey@vanderbilt.edu.

Medicine

Postdoctoral Position in Tumor Immunology:

We are seeking highly-motivated candidates for a post-doctoral research position at Vanderbilt University in Nashville to study molecular and epigenetic mechanisms of T cell differentiation and dysfunction in cancer, following up on our recent publication in Nature 545, 452–456 (25 May 2017) doi:10.1038/nature22367.

Qualified applicants must have strong knowledge and research experience in immunology and/or cancer biology and one or more of the following areas: gene editing/CRISPR/Cas9, molecular biology/cloning, computational biology/NGS data analyses, or genetically engineered mouse models. The qualified applicant must possess a PhD or MD/PhD and a strong publication record (1st author peer-reviewed publications).

The position offers a competitive salary and excellent potential for career advancement.

Applicants who are interested in this position should email 1) statement of research interests and career goals, 2) curriculum vitae including bibliography, 3) names and contact information of three references to:

Mary Philip MD PhD

mary.philip@vanderbilt.edu

Departments of Medicine and Pathology, Microbiology, and Immunology

Division of Hematology-Oncology 

Medicine

Postdoctoral position available to study the molecular pathogenesis of Helicobacter pylori infection and mechanisms by which H. pylori infection can lead to gastric cancer. Areas of interest in the lab include a broad range of topics, including secreted H. pylori toxins (VacA and CagA), a type IV secretion system encoded by the H. pylori cag pathogenicity island, H. pylori outer membrane proteins, H. pylori-induced alterations in host cells, dietary composition as a determinant of gastric cancer risk, and geographic diversity among H. pylori strains. See further details at lab website: https://my.vanderbilt.edu/coverlab/   Please send CV to Dr. Timothy L. Cover, Division of Infectious Diseases, A2200 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232. Email: timothy.L.cover@vanderbilt.edu.

Medicine

We are seeking a postdoctoral fellow to conduct multidisciplinary translational research in tumor immunology at the cutting-edge intersection of cancer biology and immunotherapy, bioinformatics, and clinical research. The ideal applicant will have a strong track record of graduate training in tumor immunology, with knowledge/proficiency in molecular and cancer biology, genomic screens, and/or basic immunology. Experience with ex vivo and in vivo murine model systems are preferred.

Our laboratory is focused on improving treatment outcomes in breast cancer (particularly triple-negative breast cancer) as well as in other solid tumors through translational approaches. To accomplish this, we integrate data from genomic and molecular profiling studies with molecular biology and signal transduction methodologies to identify altered pathways in cancer, the functional consequences of these alterations, and ways to directly target them in patients to improve clinical outcomes and survival. These efforts span in silico (publicly available databases), in vitro (cell culture), in vivo (mouse and human clinical studies) and in situ (histology) methods. There are several primary focuses of the laboratory:

1) How do tumor cells evade the immune system in cancer, and how can we target these mechanisms? We have a strong interest in the intersection between new immunotherapies and tumor cell signaling pathways. We have identified several molecular pathways that are hijacked by tumor cells in order to suppress antigen presentation, which is required for effective immunologic elimination of tumor cells. Pharmacological inhibition of these pathways can restore antigen presentation, and potentiate anti-tumor immunity. However, the mechanisms by which tumor cells evade the immune system are largely unknown. The goal of this focus is to identify these mechanisms and validate approaches to inhibit them for the benefit of patients.

2) What molecular features or biomarkers can identify patients most likely to benefit from immunotherapy? Immunotherapies have the potential to transform cancer therapy, but not all patients respond, and these drugs are incredibly costly and not without their toxicities (see #3). Thus, identifying patients most likely to benefit from immunotherapy early on, or a priori, could be incredibly valuable in triaging patients unlikely to respond to other therapies from which they are more likely to derive benefit. The discovery of molecular markers of response to immunotherapies is a major focus of the laboratory. We recently identified competence in class-II antigen presentation as a major predictor of outcome in patients treated with anti-PD-1 therapy, and are now exploring the functionality of MHC-II expression as a mediator of anti-tumor immunity.

3) What causes autoimmune-like toxicities in patients treated with immunotherapy? As mentioned above, immunotherapies have the potential to cause rare, but severe toxicities, sometimes resulting in treatment-related mortality. Understanding the mechanisms behind immunotherapy-induced autoimmunity and the molecular features of patients who exhibit them is critical area of need. Through high level molecular profiling of peripheral blood, tumors, and immune-related adverse event-affected organs, we hope to uncover hints as to why some patients exhibit these toxicities, and try to model these toxicities in the laboratory.

Fellows or trained research scientists with interest and skills in any or all of the areas are encouraged to contact the PI. The fellow will have the opportunity to:

1) Work with multidimensional data arising from exciting new human immunotherapy clinical trials being conducted by the PI to drive mechanistic studies elucidating mechanisms of sensitivity and resistance

2) Enjoy a well-funded and inter-disciplinary collaborative environment for large-scope projects in the molecular and immunotherapy translational space.

3) Drive dedicated self-directed projects in addition to collaborative projects. Applicants will be encouraged to work in a research space with a clear potential for patient impact, in a well-funded, publication-forward laboratory setting.

The trainee will be expected to work independently, and contribute creative outside-the-box ideas to the laboratory. Primarily (junior) postdoctoral fellows with a desire to work toward independent faculty academic positions or industry will be considered. Please forward your CV and a list of 3 references to justin.balko@vanderbilt.edu

Medicine

We are seeking a junior postdoctoral researcher with skills in molecular and cancer biology, translational animal models, and/or pathology to pursue novel strategies to treat a unique subtype of breast cancer called 'Inflammatory Breast Cancer'.  

Inflammatory breast cancer (IBC) is a rare special subtype of invasive breast cancer (1-5% of all breast cancers) characterized by a unique clinical presentation and molecular features. Patients presenting with IBC are often misdiagnosed due to the extreme swelling, bruising and redness of the breast, which is often a characteristic of other diseases or conditions, like mastitis. One of the key molecular features of IBC is its propensity to form tumor emboli (clusters of tumor cells) which preferentially invade into the local lymphatic system of the dermis. This feature is responsible in a large part for the clinical presentation of the disease, and also is likely related to its association with advanced clinical stage at diagnosis (almost always stage III-IV) because of local lymph node involvement. It is thought that overexpression of the tight-junction protein E-cadherin (and it’s cleavage by calpain) may be partially responsible for the formation of tumor emboli, but the reason behind the propensity of these emboli to invade and clog the lymphatic system is not known. One hypothesis for this feature is a unique response to cytokines in the microenvironment, such as IL6 and IL8, among others.

Aside from these clinical and molecular features, genomic studies have not elucidated substantial enrichments for genetic abnormalities unique to IBC. Furthermore, IBC can exist as all molecular subtypes of breast cancer, but most commonly triple-negative breast cancer (TNBC). For these reasons, IBC is often treated therapeutically as TNBC (except in rarer cases of HER2 or hormone receptor positivity). Chemotherapy is the mainstay of TNBC treatment, and response rates to chemotherapy are similar among IBC-TNBC and non-IBC-TNBC, although retrospective analyses demonstrate that IBC has a comparably poor prognosis, and is a unique molecular entity. As such, it becomes apparent that an improved understanding of the molecular features that dictate the unique clinical and pathological presentation of IBC will be paramount to designing appropriately targeted therapies to address this currently underserved molecular subtype of breast cancer.

The IBC Network Research Fellow will be supported by generous funding from the IBC Network Foundation and will work to develop murine and xenograft models of inflammatory breast cancer to test novel therapeutic strategies that can be translated for patient benefit.  Furthermore, through collaborations with Dana Farber Cancer Center and Genentech, the fellow will work with clinical human specimens of IBC to identify pathognomonic features of IBC that can be targeted and tested in the context of animal models and eventually clinical trials.

The fellow should have substantial evidence of productivity, creative thought, and independent thinking.  The ability to independently lead a project to completion is required, but the fellow will have substantial support form the PI and his laboratory.  Furthermore, a strong translational research community within the institution and laboratory can be leveraged to advance the project toward patient benefit.  

Please send a cover letter with a short write-up on interest specifically associated with this field and project, a current CV and list of three references to justin.balko@vanderbilt.edu.

Medicine

Description:

There is an immediate opening for a post-doctoral fellow position in the laboratory of Dr. Jeremy Goettel in The Department of Medicine in the Division of Gastroenterology, Hepatology, and Nutrition at the Vanderbilt University Medical Center in Nashville Tennessee. The Goettel lab utilizes translational approaches to study mucosal immunity in both murine and humanized murine systems. Specifically, we will characterize the role of IL-23R in intestinal immune homeostasis as well as develop humanized murine systems to assess therapeutic strategies that promote or restore intestinal health. This project involves working with mouse models, primary human immune cells, and established cell lines. Our lab is a member of the Digestive Disease Research Center (DDRC) and the Center for Mucosal Inflammation and Cancer (CMIC) and offers a dynamic, multidisciplinary environment with close interaction with other basic and clinical scientists. This opportunity is for a highly motivated creative individual who can drive projects and ideas forward and offer new insight and approaches that will contribute to our understanding of basic scientific questions.

Requirements and Responsibilities:

• A PhD with strong background in immunology and publication record

• Experience with in vitro and in vivo immunological assays is especially desirable.

• Assist in training new graduate students and lab technicians.

• Proficient in flow cytometry and data analysis, qPCR, molecular biology techniques.

• Present data in lab and departmental meetings as well as national and international conferences.

• Manuscript and grant writing.

To apply:

Please contact Jeremy Goettel jeremy.goettel@vanderbilt.edu with CV, cover letter and references

Medicine

Job Description

A postdoctoral position is immediately available to study the role of the airway epithelium in mucosal defense in health and in chronic airway diseases such as chronic obstructive pulmonary disease (COPD). Our growing lab investigates how airborne irritants such as cigarette smoke alter epithelial structure in the airways and the implications of altered epithelial structure on mucosal immunity. Fellows would have an opportunity to train in multiple model systems including human lung tissue, a variety of in vivo models, and primary murine and human airway epithelial cells.

Qualifications

Candidates must have a PhD or MD/PhD in stem cell/developmental biology, cell biology, immunology, or a related field. Proficiency in basic molecular biology and cell culture techniques is required; preference will be given to applicants with experience in stem cell/developmental biology of the lung, viral transduction systems, CRISPR/Cas9-based gene editing, and/or advanced microscopy. Applicants should have a demonstrated ability to work both independently and collaboratively, possess excellent oral and written communication skills, and have a record of productivity as evidenced by publication history. A successful fellow will leave the program with a broad knowledge of epithelial biology in the lung and the role of the epithelium in host defense, a robust scientific skillset, and opportunities for presentation and publication. Interested applicants should send their curriculum vitae, a brief statement of interest, and 2-3 references to Bradley Richmond at bradley.richmond@vanderbilt.edu.

Medicine

A postdoctoral position is immediately available in scientific group led by Dr. Vasiliy Polosukhin and Dr. Timothy Blackwell, Department of Medicine at Vanderbilt University School of Medicine. Our research group studies pathogenetic mechanisms of small airways diseases including chronic obstructive pulmonary disease and constrictive bronchiolitis. Specific focus of our research includes identification of mechanisms of impaired epithelial immune barrier in small conducting airways in small airways diseases and further modeling of these processes in both in vivo and in vitro systems. This postdoctoral trainee will involve in our current projects using a multitude mouse experimental models (inhalation exposure to cigarette smoke and sulfur dioxide), multiple genetically modified mouse lines, air-liquid interface cell culture. Histopathological analysis of human lung parenchymal tissue samples is also planned.

Qualifications for the Position

Candidates must have an MD and/or PhD in a medical or biological sciences field, should have ability to work both independently and collaboratively, possess strong oral and written communication skills and have a strong foundation in bench science. Successful candidates should be highly motivated and should have an expertise with human lung tissue samples, mouse models and cell culture. Specific expertise in immunohistochemistry and in situ hybridization techniques, cytokine analysis and microbiome knowledge would be helpful. Responsibilities include designing and conducting experiments, data collection and review, abstract and manuscript preparation and local and national scientific presentations. Questions about the position can be directed to vasiliy.v.polosukhin@vanderbilt.edu.

Medicine

Description of Position

A postdoctoral position is immediately available in the laboratories of Dr. Lorraine Ware, Professor of Medicine and Pathology, Microbioloby and Immunology and Dr. Julie Bastarache, Department of Medicine at Vanderbilt University School of Medicine. Our translational research group studies pathogenic mechanisms of sepsis and acute lung injury with a specific focus on mechanisms of lung epithelial and endothelial injury. A major focus is on understanding the cellular and molecular mechanisms of cell-free hemoglobin-mediated lung epithelial and microvascular endothelial permeability. This postdoctoral fellowship will afford the fellow the opportunity to drive this project forward using a multitude of tools and models available in our group including primary and immortalized cell culture, multiple genetically modifed mouse lines, mouse models of acute lung injury and sepsis as well as the ex vivo perfused human lung.

Qualifications for the Position

Candidates must have an MD and/or PhD in a related medical or biological sciences field. Successful candidates should be self-starters and highly motivated to thrive in a rich research environment. Expertise with cell culture and mouse studies is required. Specific expertise in mitochondrial biology, apoptosis, and/or redox biology would be helpful but is not required. The successful candidate should have a demonstrated ability to work both independently and collaboratively, possess strong oral and written communication skills and have a strong foundation in bench science. Responsibilities include designing and implementing experiments, data collection and review, abstract and manuscript preparation and local and national scientific presentations. A successful fellow will leave the program with a broad knowledge of acute lung injury and sepsis, a robust scientific skillset, expertise in a wide range of laboratory techniques and an opportunity for presentation and publication. Questions about the position can be directed to Lorraine.ware@vanderbilt.edu or Julie.bastarache@vanderbilt.edu.

Medicine

Description of Position

A postdoctoral position is immediately available in the laboratories of Dr. Lorraine Ware, Professor of Medicine and Pathology, Microbioloby and Immunology and Dr. Julie Bastarache, Department of Medicine at Vanderbilt University School of Medicine. Our translational research group studies pathogenic mechanisms of sepsis and acute lung injury with a specific focus on mechanisms of lung epithelial and endothelial injury. A major focus is on understanding the cellular and molecular mechanisms of cell-free hemoglobin-mediated lung epithelial and microvascular endothelial permeability. This postdoctoral fellowship will afford the fellow the opportunity to drive this project forward using a multitude of tools and models available in our group including primary and immortalized cell culture, multiple genetically modifed mouse lines, mouse models of acute lung injury and sepsis as well as the ex vivo perfused human lung.

Qualifications for the Position

Candidates must have an MD and/or PhD in a related medical or biological sciences field. Successful candidates should be self-starters and highly motivated to thrive in a rich research environment. Expertise with cell culture and mouse studies is required. Specific expertise in mitochondrial biology, apoptosis, and/or redox biology would be helpful but is not required. The successful candidate should have a demonstrated ability to work both independently and collaboratively, possess strong oral and written communication skills and have a strong foundation in bench science. Responsibilities include designing and implementing experiments, data collection and review, abstract and manuscript preparation and local and national scientific presentations. A successful fellow will leave the program with a broad knowledge of acute lung injury and sepsis, a robust scientific skillset, expertise in a wide range of laboratory techniques and an opportunity for presentation and publication. Questions about the position can be directed to Lorraine.ware@vanderbilt.edu or Julie.bastarache@vanderbilt.edu.

Medicine

The Vanderbilt Training Program in the Molecular and Genetic Epidemiology of Cancer (Vanderbilt MAGEC) is currently accepting applications for postdoctoral fellowships. The fellowship is an individualized didactic training program, tailored to complement the trainee’s background, and includes both core and elective coursework, a multi-disciplinary mentoring team, rotations in the Vanderbilt Molecular Epidemiology Lab and Survey Research Shared Resource, and the conduct of a research project. The fellowship culminates in the submission of a grant proposal to the National Institutes of Health. The goal of the program is to assist fellows in launching an independent career in epidemiological research. Over the past 4 years, two MAGEC fellows have obtained tenure track faculty positions at major universities and another two have obtained K99R00 career development grants.

MAGEC fellows have the opportunity to work on a wide range of on-going cancer epidemiological research projects and to design their own, using resources available from the Vanderbilt Epidemiology Center (VEC) and Vanderbilt University School of Medicine. The VEC is home to three large prospective cohort studies that include over 225,000 participants from diverse ethnic and socioeconomic backgrounds. Biological samples are available from over 90% of study participants. The VEC fosters cross-disciplinary research and provides exciting opportunities to investigate the interplay of environmental, lifestyle, and genetic factors in cancer epidemiology and health disparities.

The MAGEC program is specifically designed for:

• PhDs in epidemiology or genetics who have an interest in cancer research

• MDs who have an MPH degree or working experience in epidemiology

Under-represented minorities and individuals with disabilities are especially encouraged to apply. Per NIH requirements for the funding of this grant, candidates must be US citizens or permanent residents. Please visit the MAGEC website at https://medschool.vanderbilt.edu/magec/ for more information, or contact the Program Coordinator, Ms. Nan Kennedy, at nan.kennedy@vanderbilt.edu, or the Program Directors, Xiao Ou Shu, M.D., Ph.D., Medicine (Epidemiology); xiao-ou.shu@vanderbilt.edu and/or Douglas Heimburger, M.D., M.S., Medicine (Epidemiology); douglas.heimburger@Vanderbilt.Edu. Acceptance into the program is ongoing.

Medicine

The Harrison lab welcomes applications from post doctoral (or final year predoctoral) candidates with interests in early pathogenic changes associated with Alzheimer's disease and related neurodegenerative diseases.

Current projects in the lab include 1) ascorbate deficiency and altered glutamate clearance in seizures,  2) exposure to manganese and other environmental toxins, and 3) impact of critical illness and delirium on later brain function. In both projects the focus is on highlighting pathways that can be targeted by pharmacological or nutritional interventions to prevent or slow cognitive decline.

The ideal candidate will be experienced in a number of different molecular biology techniques already in use in these projects, and may also bring new techniques and experiences to the lab. Our lab is a collaborative group, with many opportunities for students to participate in research. An interest in teaching and mentoring is, therefore, also welcomed. Experience in some of the following is preferred: animal handling and colony maintenance, biochemical determination of oxidative stress, mRNA and protein expression, rodent behavioral testing, EEG, cell culture, immunohistochemistry.

In some cases, an offer may be contingent on securing training grant funding.

Medicine

We are looking for a 1st or 2nd year postdoctoral fellow to start a new project studying the role and mechanisms by which retinoic acid signaling regulates cellular repair after kidney injury, and therapeutic manipulation of this pathway in disease. The studies will involve the use of genetically modified mice, kidney injury models, careful spatial and temporal analysis of retinoic acid signaling activities in the kidney, cell sorting, bone marrow transplantation, RNA seq etc. The applicant should have experience with mice, ideally studying kidney disease, immunology experience would also be a plus. Training in kidney disease models and pathophysiology provided through the Vanderbilt Center for Kidney Disease (VCKD). A secondary basic science appointment in the Department of Cell and Developmental Biology at Vanderbilt University, as well as training in molecular medicine with Vanderbilt Program in Molecular Medicine will be encouraged

Medicine

We are seeking a postdoctoral fellow or research scientist to conduct multidisciplinary translational research in computational biology/bioinformatics at the cutting-edge intersection of cancer biology and immunotherapy, bioinformatics, and clinical research.

The ideal applicant will have a strong computational biology background, with knowledge/proficiency in molecular and cancer biology, and/or immunology. Particular experience or expertise in TCR sequencing analysis, single-cell analysis, and neoantigen prediction are highly desired.  Fellows or trained research scientists with skills in any or all of the areas are encouraged to contact the PI.

The fellow/research scientist will have the opportunity to:

1) Work with multidimensional data arising from exciting new human immunotherapy clinical trials being conducted by the PI (TCR sequencing, whole-exome sequencing, RNAseq)

2) Collaborate on computational projects in the laboratory with other trainees (mouse, human, cell line studies) for additional publications

3) Enjoy a well-funded and inter-disciplinary collaborative environment for large-scope data-driven projects in the molecular and immunotherapy translational space.

4) Drive dedicated self-directed projects in addition to collaborative projects.

Applicants will be encouraged to work in a research space with a clear potential for patient impact, in a well-funded, publication-forward laboratory setting. The trainee will be expected to work independently, and contribute creative outside-the-box ideas to the laboratory. Both postdoctoral fellows and longer-term research scientists (with possibility of promotion within the laboratory) will be considered. 

Please forward your CV and a list of 3 references to justin.balko@vanderbilt.edu

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