Alfred B. Bonds, III, Ph.D.


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Faculty Appointments
Lecturer of Electrical Engineering Professor of Biomedical Engineering, EmeritusProfessor of Electrical Engineering, Emeritus and Professor of Computer Engineering, Emeritus
Ph.D., Electrical Engineering, Northwestern University, Evanston/Chicago, IllinoisM.S., Electrical Engineering, Northwestern University, Evanston/Chicago, IllinoisA.B., Physics, Cornell University, Ithaca, New York
Office Address
VU Station B 351824, 328 Featheringill Hall
Box 1824 Sta B
Nashville, TN
Research Description
Bond's work bridges the gap between the single-cell and network models of visual cortex by exploring cell behavior in the context of activity across groups of cells. Modified reverse correlation and dual stimulation paradigms are used to create a high-resolution map of the influences of peripheral stimulation on Classic Receptive Field response characteristics. The links between oscillation, bursting and cell coupling is being studied by simultaneously recording activity across groups of 2-6 cells and assessing the relationship between oscillation and bursting, as well as how these mechanisms support synaptic communication. In addition to the information in a spike train, visual stimuli might be represented by dynamic sub-groupings of cells. Simultaneous activity in groups of cells is observed to see how correlation in their responses changes as a function of different spatial configurations of the stimulus. This work is fundamental to understanding the distributed representation of sensory information in the brain.
Research Keywords
Sensory processing, visual cortex
Samonds JM, Bonds AB. Gamma oscillation maintains stimulus structure-dependent synchronization in cat visual cortex. J. Neurophysiol [print-electronic]. 2005 Jan; 93(1): 223-36. PMID: 15282261, PII: 00548.2004, DOI: 10.1152/jn.00548.2004, ISSN: 0022-3077.

Samonds JM, Bonds AB. Real-time visualization of neural synchrony for identifying coordinated cell assemblies. J. Neurosci. Methods. 2004 Oct 10/15/2004; 139(1): 51-60. PMID: 15351521, PII: S0165027004001645, DOI: 10.1016/j.jneumeth.2004.04.035, ISSN: 0165-0270.

Samonds JM, Allison JD, Brown HA, Bonds AB. Cooperative synchronized assemblies enhance orientation discrimination. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Apr 4/27/2004; 101(17): 6722-7. PMID: 15096595, PMCID: PMC404112, PII: 0401661101, DOI: 10.1073/pnas.0401661101, ISSN: 0027-8424.

Samonds JM, Bonds AB. From another angle: Differences in cortical coding between fine and coarse discrimination of orientation. J. Neurophysiol [print-electronic]. 2004 Mar; 91(3): 1193-202. PMID: 14614106, PII: 00829.2003, DOI: 10.1152/jn.00829.2003, ISSN: 0022-3077.

Samonds JM, Allison JD, Brown HA, Bonds AB. Cooperation between area 17 neuron pairs enhances fine discrimination of orientation. J. Neurosci. 2003 Mar 3/15/2003; 23(6): 2416-25. PMID: 12657701, PII: 23/6/2416, ISSN: 1529-2401.

Brown HA, Allison JD, Samonds JM, Bonds AB. Nonlocal origin of response suppression from stimulation outside the classic receptive field in area 17 of the cat. Vis. Neurosci. 2003 Jan; 20(1): 85-96. PMID: 12699086, PII: S0952523803201097, ISSN: 0952-5238.

Xu X, Bonds AB, Casagrande VA. Modeling receptive-field structure of koniocellular, magnocellular, and parvocellular LGN cells in the owl monkey (Aotus trivigatus). Vis. Neurosci. 2002 Nov; 19(6): 703-11. PMID: 12688666, PII: S0952523802196027, ISSN: 0952-5238.

Xu X, Ichida J, Shostak Y, Bonds AB, Casagrande VA. Are primate lateral geniculate nucleus (LGN) cells really sensitive to orientation or direction?. Vis. Neurosci. 2002 Jan; 19(1): 97-108. PMID: 12180863, PII: S0952523802191097, ISSN: 0952-5238.

Kabara JF, Bonds AB. Modification of response functions of cat visual cortical cells by spatially congruent perturbing stimuli. J. Neurophysiol. 2001 Dec; 86(6): 2703-14. PMID: 11731530, ISSN: 0022-3077.

Allison JD, Smith KR, Bonds AB. Temporal-frequency tuning of cross-orientation suppression in the cat striate cortex. Vis. Neurosci. 2001 Nov; 18(6): 941-8. PMID: 12020085, PII: S0952523801186116, ISSN: 0952-5238.

Xu X, Ichida JM, Allison JD, Boyd JD, Bonds AB, Casagrande VA. A comparison of koniocellular, magnocellular and parvocellular receptive field properties in the lateral geniculate nucleus of the owl monkey (Aotus trivirgatus). J. Physiol. (Lond.). 2001 Feb 2/15/2001; 531(Pt 1): 203-18. PMID: 11179404, PMCID: PMC2278453, PII: PHY_1098, ISSN: 0022-3751.

Allison JD, Melzer P, Ding Y, Bonds AB, Casagrande VA. Differential contributions of magnocellular and parvocellular pathways to the contrast response of neurons in bush baby primary visual cortex (V1). Vis. Neurosci. 2000 Jan; 17(1): 71-6. PMID: 10750828, PII: S095252380017107X, ISSN: 0952-5238.

Snider RK, Bonds AB. Classification of non-stationary neural signals. J. Neurosci. Methods. 1998 Oct 10/1/1998; 84(1-2): 155-66. PMID: 9821647, ISSN: 0165-0270.

Snider RK, Kabara JF, Roig BR, Bonds AB. Burst firing and modulation of functional connectivity in cat striate cortex. J. Neurophysiol. 1998 Aug; 80(2): 730-44. PMID: 9705464, ISSN: 0022-3077.

DeBusk BC, DeBruyn EJ, Snider RK, Kabara JF, Bonds AB. Stimulus-dependent modulation of spike burst length in cat striate cortical cells. J. Neurophysiol. 1997 Jul; 78(1): 199-213. PMID: 9242274, ISSN: 0022-3077.

Allison JD, Kabara JF, Snider RK, Casagrande VA, Bonds AB. GABAB-receptor-mediated inhibition reduces the orientation selectivity of the sustained response of striate cortical neurons in cats. Vis. Neurosci. 1996 May; 13(3): 559-66. PMID: 8782383, PII: S0952523800008233, ISSN: 0952-5238.

Allison JD, Casagrande VA, Bonds AB. The influence of input from the lower cortical layers on the orientation tuning of upper layer V1 cells in a primate. Vis. Neurosci. 1995 Mar; 12(2): 309-20. PMID: 7786852, PII: S0952523800007999, ISSN: 0952-5238.

Pfleger B, Bonds AB. Dynamic differentiation of GABAA-sensitive influences on orientation selectivity of complex cells in the cat striate cortex. Exp Brain Res. 1995; 104(1): 81-8. PMID: 7621943, ISSN: 0014-4819.

Sun M, Bonds AB. Two-dimensional receptive-field organization in striate cortical neurons of the cat. Vis. Neurosci. 1994 Jul; 11(4): 703-20. PMID: 7918221, PII: S0952523800003011, ISSN: 0952-5238.

Allison JD, Bonds AB. Inactivation of the infragranular striate cortex broadens orientation tuning of supragranular visual neurons in the cat. Exp Brain Res. 1994; 101(3): 415-26. PMID: 7531649, ISSN: 0014-4819.

Allison JD, Casagrande VA, Debruyn EJ, Bonds AB. Contrast adaptation in striate cortical neurons of the nocturnal primate bush baby (Galago crassicaudatus). Vis. Neurosci. 1993 Nov; 10(6): 1129-39. PMID: 8257668, PII: S0952523800010233, ISSN: 0952-5238.

DeBruyn EJ, Casagrande VA, Beck PD, Bonds AB. Visual resolution and sensitivity of single cells in the primary visual cortex (V1) of a nocturnal primate (bush baby): correlations with cortical layers and cytochrome oxidase patterns. J. Neurophysiol. 1993 Jan; 69(1): 3-18. PMID: 8381862, ISSN: 0022-3077.

Bonds AB. Temporal dynamics of contrast gain in single cells of the cat striate cortex. Vis. Neurosci. 1991 Mar; 6(3): 239-55. PMID: 2054326, PII: S0952523800006258, ISSN: 0952-5238.

DeBruyn EJ, Corbett GK, Bonds AB. Pretreatment with physostigmine, mecamylamine and atropine reduces the impact of soman on the cortical visual evoked potential of the cat. Life Sci. 1991; 48(13): 1277-82. PMID: 2002756, ISSN: 0024-3205.

DeBruyn EJ, Corbett GK, Bonds AB. Depression of the cat cortical visual evoked potential by soman. Life Sci. 1991; 48(13): 1269-76. PMID: 2002755, ISSN: 0024-3205.

Pang XD, Bonds AB. Visual evoked potential responses of the anesthetized cat to contrast modulation of grating patterns. Vision Res. 1991; 31(9): 1509-16. PMID: 1949620, PII: 0042-6989(91)90128-R, ISSN: 0042-6989.

Bauman LA, Bonds AB. Inhibitory refinement of spatial frequency selectivity in single cells of the cat striate cortex. Vision Res. 1991; 31(6): 933-44. PMID: 1858324, PII: 0042-6989(91)90201-F, ISSN: 0042-6989.

Bonds AB. Role of inhibition in the specification of orientation selectivity of cells in the cat striate cortex. Vis. Neurosci. 1989; 2(1): 41-55. PMID: 2487637, PII: S0952523800004314, ISSN: 0952-5238.

Bonds AB, Casagrande VA, Norton TT, DeBruyn EJ. Visual resolution and sensitivity in a nocturnal primate (galago) measured with visual evoked potentials. Vision Res. 1987; 27(6): 845-57. PMID: 3660648, ISSN: 0042-6989.