Paul A. Harris, Ph.D.

Professor

paul.a.harris@vanderbilt.edu
Faculty Appointments
Professor of Biomedical Informatics Professor of Biomedical Engineering
Education
Ph.D., Biomedical Engineering, Vanderbilt University, Nashville, TennesseeM.S., Biomedical Engineering, Vanderbilt University, Nashville, TennesseeB.S., Mechanical Engineering, Tennessee Technological University, Cookeville, Tennessee
Office Address
2525 West End Avenue, Suite 674
Nashville, TN 37203
Publications
Muszkat M, Kurnik D, Sofowora GG, Solus J, Xie HG, Harris PA, Williams SM, Wood AJ, Stein CM. Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. J. Hypertens. 2010 Feb; 28(2): 278-84. PMID: 20051907, PMCID: PMC2895551, DOI: 10.1097/HJH.0b013e328333d212, ISSN: 1473-5598.

Kohli U, Muszkat M, Sofowora GG, Harris PA, Friedman EA, Dupont WD, Scheinin M, Wood AJ, Stein CM, Kurnik D. Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception. Eur J Pain [print-electronic]. 2010 Feb; 14(2): 154-9. PMID: 19423370, PMCID: PMC2815116, PII: S1090-3801(09)00080-9, DOI: 10.1016/j.ejpain.2009.04.003, ISSN: 1532-2149.

Pulley JM, Harris PA, Yarbrough T, Swafford J, Edwards T, Bernard GR. An informatics-based tool to assist researchers in initiating research at an academic medical center: Vanderbilt Customized Action Plan. Acad Med. 2010 Jan; 85(1): 164-8. PMID: 20042844, PMCID: PMC3767144, PII: 00001888-201001000-00041, DOI: 10.1097/ACM.0b013e3181c481bf, ISSN: 1938-808X.

Friedman EA, Harris PA, Wood AJ, Stein CM, Kurnik D. The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction. Clin. Auton. Res [print-electronic]. 2009 Aug; 19(4): 247-54. PMID: 19444546, PMCID: PMC2739683, DOI: 10.1007/s10286-009-0014-5, ISSN: 1619-1560.

Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform [print-electronic]. 2009 Apr; 42(2): 377-81. PMID: 18929686, PMCID: PMC2700030, PII: S1532-0464(08)00122-6, DOI: 10.1016/j.jbi.2008.08.010, ISSN: 1532-0480.

Kannankeril PJ, Harris PA, Norris KJ, Warsy I, Smith PD, Roden DM. Rate-independent QT shortening during exercise in healthy subjects: terminal repolarization does not shorten with exercise. J. Cardiovasc. Electrophysiol [print-electronic]. 2008 Dec; 19(12): 1284-8. PMID: 18665873, PMCID: PMC2811883, PII: JCE1266, DOI: 10.1111/j.1540-8167.2008.01266.x, ISSN: 1540-8167.

Kurnik D, Li C, Sofowora GG, Friedman EA, Muszkat M, Xie HG, Harris PA, Williams SM, Nair UB, Wood AJ, Stein CM. Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade. Pharmacogenet. Genomics. 2008 Oct; 18(10): 895-902. PMID: 18794726, PMCID: PMC2757009, PII: 01213011-200810000-00010, DOI: 10.1097/FPC.0b013e328309733f, ISSN: 1744-6872.

Garland EM, Raj SR, Black BK, Harris PA, Robertson D. The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome. Neurology. 2007 Aug 8/21/2007; 69(8): 790-8. PMID: 17709712, PII: 69/8/790, DOI: 10.1212/01.wnl.0000267663.05398.40, ISSN: 1526-632X.

Garland EM, Black BK, Harris PA, Robertson D. Dopamine-beta-hydroxylase in postural tachycardia syndrome. Am. J. Physiol. Heart Circ. Physiol. 2007 Jul; 293(1): H684-90. PMID: 17625104, PII: 293/1/H684, DOI: 10.1152/ajpheart.01389.2006, ISSN: 0363-6135.

Kurnik D, Muszkat M, Friedman EA, Sofowora GG, Diedrich A, Xie HG, Harris PA, Choi L, Wood AJ, Stein CM. Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects. J. Hypertens. 2007 Apr; 25(4): 763-71. PMID: 17351367, PII: 00004872-200704000-00006, DOI: 10.1097/HJH.0b013e328017f6e9, ISSN: 0263-6352.

Friedman EA, Harris PA, Wood AJ, Stein CM, Kurnik D. The effects of tadalafil on cold-induced vasoconstriction in patients with Raynaud's phenomenon. Clin. Pharmacol. Ther [print-electronic]. 2007 Apr; 81(4): 503-9. PMID: 17301734, PII: 6100103, DOI: 10.1038/sj.clpt.6100103, ISSN: 0009-9236.

Abou-Khalil B, Krei L, Lazenby B, Harris PA, Haines JL, Hedera P. Familial genetic predisposition, epilepsy localization and antecedent febrile seizures. Epilepsy Res [print-electronic]. 2007 Jan; 73(1): 104-10. PMID: 17046202, PII: S0920-1211(06)00354-8, DOI: 10.1016/j.eplepsyres.2006.08.005, ISSN: 0920-1211.

Raj SR, Biaggioni I, Black BK, Rali A, Jordan J, Taneja I, Harris PA, Robertson D. Sodium paradoxically reduces the gastropressor response in patients with orthostatic hypotension. Hypertension [print-electronic]. 2006 Aug; 48(2): 329-34. PMID: 16785332, PII: 01.HYP.0000229906.27330.4f, DOI: 10.1161/01.HYP.0000229906.27330.4f, ISSN: 1524-4563.

Kurnik D, Muszkat M, Li C, Sofowora GG, Solus J, Xie HG, Harris PA, Jiang L, McMunn C, Ihrie P, Dawson EP, Williams SM, Wood AJ, Stein CM. Variations in the alpha2A-adrenergic receptor gene and their functional effects. Clin. Pharmacol. Ther [print-electronic]. 2006 Mar; 79(3): 173-85. PMID: 16513442, PII: S0009-9236(05)00474-1, DOI: 10.1016/j.clpt.2005.10.006, ISSN: 0009-9236.

Garland EM, Winker R, Williams SM, Jiang L, Stanton K, Byrne DW, Biaggioni I, Cascorbi I, Phillips JA, Harris PA, RĂ¼diger H, Robertson D. Endothelial NO synthase polymorphisms and postural tachycardia syndrome. Hypertension [print-electronic]. 2005 Nov; 46(5): 1103-10. PMID: 16203873, PII: 01.HYP.0000185462.08685.da, DOI: 10.1161/01.HYP.0000185462.08685.da, ISSN: 1524-4563.

Harris PA, Lane L, Biaggioni I. Clinical research subject recruitment: the Volunteer for Vanderbilt Research Program www.volunteer.mc.vanderbilt.edu. J Am Med Inform Assoc [print-electronic]. 2005 Nov; 12(6): 608-13. PMID: 16049231, PMCID: PMC1294031, PII: M1722, DOI: 10.1197/jamia.M1722, ISSN: 1067-5027.

Raj SR, Black BK, Biaggioni I, Harris PA, Robertson D. Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome. Circulation [print-electronic]. 2005 May 5/31/2005; 111(21): 2734-40. PMID: 15911704, PII: CIRCULATIONAHA.104.497594, DOI: 10.1161/CIRCULATIONAHA.104.497594, ISSN: 1524-4539.

Shibao C, Arzubiaga C, Roberts LJ, Raj S, Black B, Harris P, Biaggioni I. Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders. Hypertension [print-electronic]. 2005 Mar; 45(3): 385-90. PMID: 15710782, PII: 01.HYP.0000158259.68614.40, DOI: 10.1161/01.HYP.0000158259.68614.40, ISSN: 1524-4563.

Grogan EL, Norris PR, Speroff T, Ozdas A, France DJ, Harris PA, Jenkins JM, Stiles R, Dittus RS, Morris JA. Volatility: a new vital sign identified using a novel bedside monitoring strategy. J Trauma. 2005 Jan; 58(1): 7-12; discussion 12. PMID: 15674143, PII: 00005373-200501000-00002, ISSN: 0022-5282.

Grogan EL, Morris JA, Norris PR, France DJ, Ozdas A, Stiles RA, Harris PA, Dawant BM, Speroff T. Reduced heart rate volatility: an early predictor of death in trauma patients. Ann. Surg. 2004 Sep; 240(3): 547-54; discussion 554. PMID: 15319726, PMCID: PMC1356445, PII: 00000658-200409000-00016, ISSN: 0003-4932.

Dishy V, Harris PA, Pierce R, Prasad HC, Sofowora G, Bonar HL, Wood AJ, Stein CM. Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers. Br J Clin Pharmacol. 2004 Feb; 57(2): 209-12. PMID: 14748820, PMCID: PMC1884430, PII: 1974, ISSN: 0306-5251.

Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, Wright PF, Crowe JE. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N. Engl. J. Med. 2004 Jan 1/29/2004; 350(5): 443-50. PMID: 14749452, PMCID: PMC1831873, PII: 350/5/443, DOI: 10.1056/NEJMoa025472, ISSN: 1533-4406.

Lu CC, Diedrich A, Tung CS, Paranjape SY, Harris PA, Byrne DW, Jordan J, Robertson D. Water ingestion as prophylaxis against syncope. Circulation [print-electronic]. 2003 Nov 11/25/2003; 108(21): 2660-5. PMID: 14623807, PII: 01.CIR.0000101966.24899.CB, DOI: 10.1161/01.CIR.0000101966.24899.CB, ISSN: 1524-4539.

Sofowora GG, Dishy V, Muszkat M, Xie HG, Kim RB, Harris PA, Prasad HC, Byrne DW, Nair UB, Wood AJ, Stein CM. A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade. Clin. Pharmacol. Ther. 2003 Apr; 73(4): 366-71. PMID: 12709726, PII: S0009923602177344, ISSN: 0009-9236.

Cohen JA, Arain A, Harris PA, Byrne DW, Holzman MD, Sharp KW, Richards WO. Surgical trial investigating nocturnal gastroesophageal reflux and sleep (STINGERS). Surg Endosc [print-electronic]. 2003 Mar; 17(3): 394-400. PMID: 12436237, DOI: 10.1007/s00464-002-8912-9, ISSN: 1432-2218.

Dishy V, Sofowora G, Harris PA, Kandcer M, Zhan F, Wood AJ, Stein CM. The effect of sildenafil on nitric oxide-mediated vasodilation in healthy men. Clin. Pharmacol. Ther. 2001 Sep; 70(3): 270-9. PMID: 11557915, PII: S0009-9236(01)08656-8, DOI: 10.1067/mcp.2001.117995, ISSN: 0009-9236.

Xie HG, Dishy V, Sofowora G, Kim RB, Landau R, Smiley RM, Zhou HH, Wood AJ, Harris P, Stein CM. Arg389Gly beta 1-adrenoceptor polymorphism varies in frequency among different ethnic groups but does not alter response in vivo. Pharmacogenetics. 2001 Apr; 11(3): 191-7. PMID: 11337934, ISSN: 0960-314X.

Furlan R, Jacob G, Snell M, Robertson D, Porta A, Harris P, Mosqueda-Garcia R. Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control. Circulation. 1998 Nov 11/17/1998; 98(20): 2154-9. PMID: 9815870, ISSN: 0009-7322.

Harris PA, Bosan S, Harris TR, Laughlin MH, Overholser KA. Parameter identification in coronary pressure flow models: a graphical approach. Ann Biomed Eng. 1994 Nov; 22(6): 622-37. PMID: 7872572, ISSN: 0090-6964.