Faculty Appointments
Professor of Physics
A.B. Learned Chair in Living State Physics
Education
Ph.D., Biophysics, University of Virginia, Charlottesville, VirginiaM.S., Physics, Wake Forest University, Winston-Salem, North CarolinaB.A., Physics, Wake Forest University, Winston-Salem, North Carolina
Office Address
Stevenson Center 6301
Nashville, TN 37235
Nashville, TN 37235
Research Description
My research interests are in biological physics — specifically in how biological systems can be probed and manipulated by light (biophotonics), in how cellular forces drive tissue morphogenesis (biomechanics), and in how embryonic development is disturbed by environmental exposures (systems biology of developmental toxicology).
Current projects in the lab include:
-- investigating the mechanisms by which cells detect nearby wounds, trigger calcium signals, and marshal wound-closure responses;
-- using modeling and laser-microsurgery to probe the inter- and intra-cellular forces that drive morphogenesis; and
-- using computational models and organs-on-a-chip technologies to investigate the mechanisms of developmental toxicity.
Current projects in the lab include:
-- investigating the mechanisms by which cells detect nearby wounds, trigger calcium signals, and marshal wound-closure responses;
-- using modeling and laser-microsurgery to probe the inter- and intra-cellular forces that drive morphogenesis; and
-- using computational models and organs-on-a-chip technologies to investigate the mechanisms of developmental toxicity.
Research Keywords
Mechanics of Drosophila embryogenesis; laser-microsurgery; laser-tissue interactions; wound healing; organs-on-chips
Publications
Stevens AC, O'Connor JT, Pumford AD, Page-McCaw A, Hutson MS. A mathematical model of calcium signals around laser-induced epithelial wounds. Mol Biol Cell [print-electronic]. 2022 Nov 11/2/2022; mbcE22080361. PMID: 36322412, DOI: 10.1091/mbc.E22-08-0361, ISSN: 1939-4586.
O'Connor JT, Shannon EK, Hutson MS, Page-McCaw A. Mounting Drosophila pupae for laser ablation and live imaging of the dorsal thorax. STAR Protoc. 2022 Jun 6/17/2022; 3(2): 101396. PMID: 35600923, PMCID: PMC9117934, PII: S2666-1667(22)00276-3, DOI: 10.1016/j.xpro.2022.101396, ISSN: 2666-1667.
O'Connor JT, Stevens AC, Shannon EK, Akbar FB, LaFever KS, Narayanan NP, Gailey CD, Hutson MS, Page-McCaw A. Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection. Dev Cell [print-electronic]. 2021 Aug 8/9/2021; 56(15): 2160-2175.e5. PMID: 34273275, PMCID: PMC8367014, PII: S1534-5807(21)00527-X, DOI: 10.1016/j.devcel.2021.06.020, ISSN: 1878-1551.
O'Connor J, Akbar FB, Hutson MS, Page-McCaw A. Zones of cellular damage around pulsed-laser wounds. PLoS One. 2021; 16(9): e0253032. PMID: 34570791, PMCID: PMC8476025, PII: PONE-D-21-17115, DOI: 10.1371/journal.pone.0253032, ISSN: 1932-6203.
McCleery WT, Veldhuis J, Bennett ME, Lynch HE, Ma X, Brodland GW, Hutson MS. Elongated Cells Drive Morphogenesis in a Surface-Wrapped Finite-Element Model of Germband Retraction. Biophys J [print-electronic]. 2019 Jul 7/9/2019; 117(1): 157-69. PMID: 31229244, PMCID: PMC6626845, PII: S0006-3495(19)30443-6, DOI: 10.1016/j.bpj.2019.05.023, ISSN: 1542-0086.
Auner AW, Tasneem KM, Markov DA, McCawley LJ, Hutson MS. Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices. Lab Chip. 2019 Feb 2/26/2019; 19(5): 864-74. PMID: 30720811, PMCID: PMC6512955, DOI: 10.1039/c8lc00796a, ISSN: 1473-0189.
Shannon EK, Stevens A, Edrington W, Zhao Y, Jayasinghe AK, Page-McCaw A, Hutson MS. Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial Wounds. Biophys J. 2017 Oct 10/3/2017; 113(7): 1623-35. PMID: 28978452, PMCID: PMC5627067, PII: S0006-3495(17)30847-0, DOI: 10.1016/j.bpj.2017.07.022, ISSN: 1542-0086.
Hutson MS, Brodland GW, Yang J, Viens D. Cell sorting in three dimensions: topology, fluctuations, and fluidlike instabilities. Phys Rev Lett [print-electronic]. 2008 Oct 10/3/2008; 101(14): 148105. PMID: 18851581, DOI: 10.1103/PhysRevLett.101.148105, ISSN: 0031-9007.
Hutson MS, Ma X. Mechanical aspects of developmental biology: perspectives on growth and form in the (post)-genomic age. Preface. Phys Biol. 2008 Apr 4/10/2008; 5(1): 15001. PMID: 18403828, PII: S1478-3975(08)73689-6, DOI: 10.1088/1478-3975/5/1/015001, ISSN: 1478-3975.
Hutson MS, Ma X. Plasma and cavitation dynamics during pulsed laser microsurgery in vivo. Phys Rev Lett [print-electronic]. 2007 Oct 10/12/2007; 99(15): 158104. PMID: 17995217, DOI: 10.1103/PhysRevLett.99.158104, ISSN: 0031-9007.
O'Connor JT, Shannon EK, Hutson MS, Page-McCaw A. Mounting Drosophila pupae for laser ablation and live imaging of the dorsal thorax. STAR Protoc. 2022 Jun 6/17/2022; 3(2): 101396. PMID: 35600923, PMCID: PMC9117934, PII: S2666-1667(22)00276-3, DOI: 10.1016/j.xpro.2022.101396, ISSN: 2666-1667.
O'Connor JT, Stevens AC, Shannon EK, Akbar FB, LaFever KS, Narayanan NP, Gailey CD, Hutson MS, Page-McCaw A. Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection. Dev Cell [print-electronic]. 2021 Aug 8/9/2021; 56(15): 2160-2175.e5. PMID: 34273275, PMCID: PMC8367014, PII: S1534-5807(21)00527-X, DOI: 10.1016/j.devcel.2021.06.020, ISSN: 1878-1551.
O'Connor J, Akbar FB, Hutson MS, Page-McCaw A. Zones of cellular damage around pulsed-laser wounds. PLoS One. 2021; 16(9): e0253032. PMID: 34570791, PMCID: PMC8476025, PII: PONE-D-21-17115, DOI: 10.1371/journal.pone.0253032, ISSN: 1932-6203.
McCleery WT, Veldhuis J, Bennett ME, Lynch HE, Ma X, Brodland GW, Hutson MS. Elongated Cells Drive Morphogenesis in a Surface-Wrapped Finite-Element Model of Germband Retraction. Biophys J [print-electronic]. 2019 Jul 7/9/2019; 117(1): 157-69. PMID: 31229244, PMCID: PMC6626845, PII: S0006-3495(19)30443-6, DOI: 10.1016/j.bpj.2019.05.023, ISSN: 1542-0086.
Auner AW, Tasneem KM, Markov DA, McCawley LJ, Hutson MS. Chemical-PDMS binding kinetics and implications for bioavailability in microfluidic devices. Lab Chip. 2019 Feb 2/26/2019; 19(5): 864-74. PMID: 30720811, PMCID: PMC6512955, DOI: 10.1039/c8lc00796a, ISSN: 1473-0189.
Shannon EK, Stevens A, Edrington W, Zhao Y, Jayasinghe AK, Page-McCaw A, Hutson MS. Multiple Mechanisms Drive Calcium Signal Dynamics around Laser-Induced Epithelial Wounds. Biophys J. 2017 Oct 10/3/2017; 113(7): 1623-35. PMID: 28978452, PMCID: PMC5627067, PII: S0006-3495(17)30847-0, DOI: 10.1016/j.bpj.2017.07.022, ISSN: 1542-0086.
Hutson MS, Brodland GW, Yang J, Viens D. Cell sorting in three dimensions: topology, fluctuations, and fluidlike instabilities. Phys Rev Lett [print-electronic]. 2008 Oct 10/3/2008; 101(14): 148105. PMID: 18851581, DOI: 10.1103/PhysRevLett.101.148105, ISSN: 0031-9007.
Hutson MS, Ma X. Mechanical aspects of developmental biology: perspectives on growth and form in the (post)-genomic age. Preface. Phys Biol. 2008 Apr 4/10/2008; 5(1): 15001. PMID: 18403828, PII: S1478-3975(08)73689-6, DOI: 10.1088/1478-3975/5/1/015001, ISSN: 1478-3975.
Hutson MS, Ma X. Plasma and cavitation dynamics during pulsed laser microsurgery in vivo. Phys Rev Lett [print-electronic]. 2007 Oct 10/12/2007; 99(15): 158104. PMID: 17995217, DOI: 10.1103/PhysRevLett.99.158104, ISSN: 0031-9007.