Lawrence J. Marnett, Ph.D.

University Professor

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Faculty Appointments
Dean of Basic Sciences University Professor of Biochemistry and Chemistry Professor of Chemistry Mary Geddes Stahlman Chair in Cancer ResearchProfessor of Pharmacology
Ph.D., CHEMISTRY, Duke University, Durham, North CarolinaB.S., Rockhurst College, Kansas City, Missouri
Office Address
850 RRB
TN 0146
Research Description
A major interest in the Marnett laboratory is the structure and function of cyclooxygenase-2 (COX-2). This enzyme catalyzes the committed step in the production of prostaglandins and is the molecular target for non-steroidal antiinflammatory drugs. Functional analysis of COX-2 by structure-guided mutagenesis has uncovered new strategies for synthesizing COX-2 inhibitors and has suggested new biological roles for the enzyme. Current work focuses on the generation of novel antiinflammatory drugs with additional pharmacological functions and on investigations of the chemistry and biology of COX-2-dependent oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins.

Another major interest in the Marnett laboratory is the chemistry and biology of DNA damage by endogenously generated products of oxidative stress. Individual products of DNA damage are incorporated into viral genomes for in vivo mutagenesis experiments. Similar experiments are used to identify human DNA repair enzymes that remove specific forms of DNA damage.

A new area of interest in the laboratory is the investigation of protein targets of drugs and toxic compounds and the consequences of protein modification in modulating biological function.

A broad range of techniques are used by the Marnett group including chemical synthesis, enzymology, protein expression, site-directed mutagenesis, bioanalytical chemistry, mass spectrometry, in vivo mutagenesis, tissue culture, proteomics, and techniques of signal transduction.

Research Keywords
Cyclooxygenase-2 structure and function; chemistry and biology of DNA damage-dependent mutagenesis and signaling
VanderVeen LA, Harris TM, Jen-Jacobson L, Marnett LJ. Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI. Chem. Res. Toxicol [print-electronic]. 2008 Sep; 21(9): 1733-8. PMID: 18690724, PMCID: PMC2651693, DOI: 10.1021/tx800092g, ISSN: 1520-5010.

Felts AS, Siegel BS, Young SM, Moth CW, Lybrand TP, Dannenberg AJ, Marnett LJ, Subbaramaiah K. Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition. J. Med. Chem [print-electronic]. 2008 Aug 8/28/2008; 51(16): 4911-9. PMID: 18665581, PMCID: PMC2651753, DOI: 10.1021/jm700969c, ISSN: 1520-4804.

Wang Y, Musser SK, Saleh S, Marnett LJ, Egli M, Stone MP. Insertion of dNTPs opposite the 1,N2-propanodeoxyguanosine adduct by Sulfolobus solfataricus P2 DNA polymerase IV. Biochemistry [print-electronic]. 2008 Jul 7/15/2008; 47(28): 7322-34. PMID: 18563918, PMCID: PMC2753402, DOI: 10.1021/bi800152j, ISSN: 1520-4995.

Ghidu VP, Wang J, Wu B, Liu Q, Jacobs A, Marnett LJ, Sulikowski GA. Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D. J. Org. Chem [print-electronic]. 2008 Jul 7/4/2008; 73(13): 4949-55. PMID: 18543990, PMCID: PMC2572754, DOI: 10.1021/jo800545r, ISSN: 1520-6904.

Knutson CG, Skipper PL, Liberman RG, Tannenbaum SR, Marnett LJ. Monitoring in vivo metabolism and elimination of the endogenous DNA adduct, M1dG {3-(2-deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin-10(3H)-one}, by accelerator mass spectrometry. Chem. Res. Toxicol [print-electronic]. 2008 Jun; 21(6): 1290-4. PMID: 18461974, PMCID: PMC3214661, DOI: 10.1021/tx800049v, ISSN: 1520-5010.

Bala M, Chin CN, Logan AT, Amin T, Marnett LJ, Boutaud O, Oates JA. Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase. Biochem. Pharmacol [print-electronic]. 2008 Apr 4/1/2008; 75(7): 1472-81. PMID: 18242581, PMCID: PMC2693035, PII: S0006-2952(07)00818-0, DOI: 10.1016/j.bcp.2007.12.005, ISSN: 1873-2968.

Rouzer CA, Marnett LJ. Non-redundant functions of cyclooxygenases: oxygenation of endocannabinoids. J. Biol. Chem [print-electronic]. 2008 Mar 3/28/2008; 283(13): 8065-9. PMID: 18250160, PMCID: PMC2417164, PII: R800005200, DOI: 10.1074/jbc.R800005200, ISSN: 0021-9258.

Turman MV, Kingsley PJ, Rouzer CA, Cravatt BF, Marnett LJ. Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine. Biochemistry [print-electronic]. 2008 Mar 3/25/2008; 47(12): 3917-25. PMID: 18311922, PMCID: PMC2760074, DOI: 10.1021/bi702530z, ISSN: 0006-2960.

Szekely J, Rizzo CJ, Marnett LJ. Chemical properties of oxopropenyl adducts of purine and pyrimidine nucleosides and their reactivity toward amino acid cross-link formation. J. Am. Chem. Soc [print-electronic]. 2008 Feb 2/20/2008; 130(7): 2195-201. PMID: 18225895, PMCID: PMC2708936, DOI: 10.1021/ja074506u, ISSN: 1520-5126.

Vila A, Tallman KA, Jacobs AT, Liebler DC, Porter NA, Marnett LJ. Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives. Chem. Res. Toxicol [print-electronic]. 2008 Feb; 21(2): 432-44. PMID: 18232660, PMCID: PMC2760080, DOI: 10.1021/tx700347w, ISSN: 0893-228X.

Szekely J, Wang H, Peplowski KM, Knutson CG, Marnett LJ, Rizzo CJ. "One-pot" syntheses of malondialdehyde adducts of nucleosides. Nucleosides Nucleotides Nucleic Acids. 2008 Feb; 27(2): 103-9. PMID: 18205065, PMCID: PMC3129002, PII: 789722897, DOI: 10.1080/15257770701795797, ISSN: 1525-7770.

Stafford JB, Marnett LJ. Prostaglandin E2 inhibits tumor necrosis factor-alpha RNA through PKA type I. Biochem. Biophys. Res. Commun [print-electronic]. 2008 Feb 2/1/2008; 366(1): 104-9. PMID: 18060853, PMCID: PMC2761429, PII: S0006-291X(07)02509-0, DOI: 10.1016/j.bbrc.2007.11.091, ISSN: 1090-2104.

Knutson CG, Wang H, Rizzo CJ, Marnett LJ. Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-beta-D-erythropentofuranosyl)-pyrimido[1,2-alpha]purine-10(3H)-one, in the rat. J. Biol. Chem [print-electronic]. 2007 Dec 12/14/2007; 282(50): 36257-64. PMID: 17951255, PII: M706814200, DOI: 10.1074/jbc.M706814200, ISSN: 0021-9258.

Jacobs AT, Marnett LJ. Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL. J. Biol. Chem [print-electronic]. 2007 Nov 11/16/2007; 282(46): 33412-20. PMID: 17873279, PII: M706799200, DOI: 10.1074/jbc.M706799200, ISSN: 0021-9258.

Druckova A, Mernaugh RL, Ham AJ, Marnett LJ. Identification of the protein targets of the reactive metabolite of teucrin A in vivo in the rat. Chem. Res. Toxicol [print-electronic]. 2007 Oct; 20(10): 1393-408. PMID: 17892266, DOI: 10.1021/tx7001405, ISSN: 0893-228X.

Vila A, Rosengarth A, Piomelli D, Cravatt B, Marnett LJ. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry [print-electronic]. 2007 Aug 8/21/2007; 46(33): 9578-85. PMID: 17649977, DOI: 10.1021/bi7005898, ISSN: 0006-2960.

Joo M, Kwon M, Sadikot RT, Kingsley PJ, Marnett LJ, Blackwell TS, Peebles RS, Urade Y, Christman JW. Induction and function of lipocalin prostaglandin D synthase in host immunity. J. Immunol. 2007 Aug 8/15/2007; 179(4): 2565-75. PMID: 17675519, PII: 179/4/2565, ISSN: 0022-1767.

Prusakiewicz JJ, Turman MV, Vila A, Ball HL, Al-Mestarihi AH, Di Marzo V, Marnett LJ. Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases. Arch. Biochem. Biophys [print-electronic]. 2007 Aug 8/15/2007; 464(2): 260-8. PMID: 17493578, PMCID: PMC2774498, PII: S0003-9861(07)00189-0, DOI: 10.1016/, ISSN: 0003-9861.

Wang Y, Schnetz-Boutaud NC, Saleh S, Marnett LJ, Stone MP. Bulge migration of the malondialdehyde OPdG DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene. Chem. Res. Toxicol [print-electronic]. 2007 Aug; 20(8): 1200-10. PMID: 17645303, PMCID: PMC2728581, DOI: 10.1021/tx700121j, ISSN: 0893-228X.

Blobaum AL, Marnett LJ. Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib. J. Biol. Chem [print-electronic]. 2007 Jun 6/1/2007; 282(22): 16379-90. PMID: 17434872, PII: M609883200, DOI: 10.1074/jbc.M609883200, ISSN: 0021-9258.

Rouzer CA, Ivanova PT, Byrne MO, Brown HA, Marnett LJ. Lipid profiling reveals glycerophospholipid remodeling in zymosan-stimulated macrophages. Biochemistry [print-electronic]. 2007 May 5/22/2007; 46(20): 6026-42. PMID: 17458939, DOI: 10.1021/bi0621617, ISSN: 0006-2960.

Blobaum AL, Marnett LJ. Structural and functional basis of cyclooxygenase inhibition. J. Med. Chem [print-electronic]. 2007 Apr 4/5/2007; 50(7): 1425-41. PMID: 17341061, DOI: 10.1021/jm0613166, ISSN: 0022-2623.

Knutson CG, Akingbade D, Crews BC, Voehler M, Stec DF, Marnett LJ. Metabolism in vitro and in vivo of the DNA base adduct, M1G. Chem. Res. Toxicol [print-electronic]. 2007 Mar; 20(3): 550-7. PMID: 17311424, DOI: 10.1021/tx600334x, ISSN: 0893-228X.

Wang H, Xie H, Sun X, Kingsley PJ, Marnett LJ, Cravatt BF, Dey SK. Differential regulation of endocannabinoid synthesis and degradation in the uterus during embryo implantation. Prostaglandins Other Lipid Mediat [print-electronic]. 2007 Feb; 83(1-2): 62-74. PMID: 17259073, PMCID: PMC1805469, PII: S1098-8823(06)00143-2, DOI: 10.1016/j.prostaglandins.2006.09.009, ISSN: 1098-8823.

Kingsley PJ, Marnett LJ. LC-MS-MS analysis of neutral eicosanoids. Meth. Enzymol. 2007; 433: 91-112. PMID: 17954230, PII: S0076-6879(07)33005-X, DOI: 10.1016/S0076-6879(07)33005-X, ISSN: 0076-6879.

Rouzer CA, Ivanova PT, Byrne MO, Milne SB, Marnett LJ, Brown HA. Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implications. Biochemistry. 2006 Dec 12/12/2006; 45(49): 14795-808. PMID: 17144673, PMCID: PMC2443946, DOI: 10.1021/bi061723j, ISSN: 0006-2960.

Wang H, Kozekov ID, Kozekova A, Tamura PJ, Marnett LJ, Harris TM, Rizzo CJ. Site-specific synthesis of oligonucleotides containing malondialdehyde adducts of deoxyguanosine and deoxyadenosine via a postsynthetic modification strategy. Chem. Res. Toxicol. 2006 Nov; 19(11): 1467-74. PMID: 17112234, PMCID: PMC2441645, DOI: 10.1021/tx060137o, ISSN: 0893-228X.

Druckova A, Marnett LJ. Characterization of the amino acid adducts of the enedial derivative of teucrin A. Chem. Res. Toxicol. 2006 Oct; 19(10): 1330-40. PMID: 17040102, DOI: 10.1021/tx060143k, ISSN: 0893-228X.

Rouzer CA, Tranguch S, Wang H, Zhang H, Dey SK, Marnett LJ. Zymosan-induced glycerylprostaglandin and prostaglandin synthesis in resident peritoneal macrophages: roles of cyclo-oxygenase-1 and -2. Biochem. J. 2006 Oct 10/1/2006; 399(1): 91-9. PMID: 16787386, PMCID: PMC1570173, PII: BJ20060615, DOI: 10.1042/BJ20060615, ISSN: 1470-8728.

Wang H, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK, Cravatt BF, Dey SK. Fatty acid amide hydrolase deficiency limits early pregnancy events. J. Clin. Invest. 2006 Aug; 116(8): 2122-31. PMID: 16886060, PMCID: PMC1523389, DOI: 10.1172/JCI28621, ISSN: 0021-9738.

Otteneder MB, Knutson CG, Daniels JS, Hashim M, Crews BC, Remmel RP, Wang H, Rizzo C, Marnett LJ. In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Apr 4/25/2006; 103(17): 6665-9. PMID: 16614064, PMCID: PMC1458938, PII: 0602017103, DOI: 10.1073/pnas.0602017103, ISSN: 0027-8424.

West JD, Marnett LJ. Endogenous reactive intermediates as modulators of cell signaling and cell death. Chem. Res. Toxicol. 2006 Feb; 19(2): 173-94. PMID: 16485894, DOI: 10.1021/tx050321u, ISSN: 0893-228X.

Muthian G, Raikwar HP, Johnson C, Rajasingh J, Kalgutkar A, Marnett LJ, Bright JJ. COX-2 inhibitors modulate IL-12 signaling through JAK-STAT pathway leading to Th1 response in experimental allergic encephalomyelitis. J. Clin. Immunol. 2006 Jan; 26(1): 73-85. PMID: 16418805, DOI: 10.1007/s10875-006-8787-y, ISSN: 0271-9142.

Kalgutkar AS, Crews BC, Saleh S, Prudhomme D, Marnett LJ. Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors. Bioorg. Med. Chem [print-electronic]. 2005 Dec 12/15/2005; 13(24): 6810-22. PMID: 16169736, PII: S0968-0896(05)00732-7, DOI: 10.1016/j.bmc.2005.07.073, ISSN: 0968-0896.

Rouzer CA, Marnett LJ. Structural and functional differences between cyclooxygenases: fatty acid oxygenases with a critical role in cell signaling. Biochem. Biophys. Res. Commun [print-electronic]. 2005 Dec 12/9/2005; 338(1): 34-44. PMID: 16126167, PII: S0006-291X(05)01751-1, DOI: 10.1016/j.bbrc.2005.07.198, ISSN: 0006-291X.

West JD, Marnett LJ. Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal. Chem. Res. Toxicol. 2005 Nov; 18(11): 1642-53. PMID: 16300372, DOI: 10.1021/tx050211n, ISSN: 0893-228X.

Kingsley PJ, Rouzer CA, Saleh S, Marnett LJ. Simultaneous analysis of prostaglandin glyceryl esters and prostaglandins by electrospray tandem mass spectrometry. Anal. Biochem. 2005 Aug 8/15/2005; 343(2): 203-11. PMID: 16004953, PII: S0003-2697(05)00366-0, DOI: 10.1016/j.ab.2005.05.005, ISSN: 0003-2697.

Burleigh ME, Babaev VR, Patel MB, Crews BC, Remmel RP, Morrow JD, Oates JA, Marnett LJ, Fazio S, Linton MF. Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice. Biochem. Pharmacol. 2005 Aug 8/1/2005; 70(3): 334-42. PMID: 15950196, PII: S0006-2952(05)00285-6, DOI: 10.1016/j.bcp.2005.04.044, ISSN: 0006-2952.

Rouzer CA, Marnett LJ. Glycerylprostaglandin synthesis by resident peritoneal macrophages in response to a zymosan stimulus. J. Biol. Chem [print-electronic]. 2005 Jul 7/22/2005; 280(29): 26690-700. PMID: 15917246, PII: M501021200, DOI: 10.1074/jbc.M501021200, ISSN: 0021-9258.

Guo Y, Wang H, Okamoto Y, Ueda N, Kingsley PJ, Marnett LJ, Schmid HH, Das SK, Dey SK. N-acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J. Biol. Chem [print-electronic]. 2005 Jun 6/24/2005; 280(25): 23429-32. PMID: 15890658, PII: C500168200, DOI: 10.1074/jbc.C500168200, ISSN: 0021-9258.

Moth CW, Prusakiewicz JJ, Marnett LJ, Lybrand TP. Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1. J. Med. Chem. 2005 May 5/19/2005; 48(10): 3613-20. PMID: 15887968, DOI: 10.1021/jm0494164, ISSN: 0022-2623.

Rouzer CA, Jacobs AT, Nirodi CS, Kingsley PJ, Morrow JD, Marnett LJ. RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretion. J. Lipid Res [print-electronic]. 2005 May; 46(5): 1027-37. PMID: 15722559, PII: M500006-JLR200, DOI: 10.1194/jlr.M500006-JLR200, ISSN: 0022-2275.

West JD, Ji C, Marnett LJ. Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1. J. Biol. Chem [print-electronic]. 2005 Apr 4/15/2005; 280(15): 15141-7. PMID: 15703174, PII: M413147200, DOI: 10.1074/jbc.M413147200, ISSN: 0021-9258.

VanderVeen LA, Druckova A, Riggins JN, Sorrells JL, Guengerich FP, Marnett LJ. Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct. Biochemistry. 2005 Apr 4/5/2005; 44(13): 5024-33. PMID: 15794640, DOI: 10.1021/bi0472898, ISSN: 0006-2960.

Vélez-Cruz R, Riggins JN, Daniels JS, Cai H, Guengerich FP, Marnett LJ, Osheroff N. Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry. 2005 Mar 3/15/2005; 44(10): 3972-81. PMID: 15751973, DOI: 10.1021/bi0478289, ISSN: 0006-2960.

Hata AN, Lybrand TP, Marnett LJ, Breyer RM. Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. Mol. Pharmacol [print-electronic]. 2005 Mar; 67(3): 640-7. PMID: 15563582, PII: mol.104.007971, DOI: 10.1124/mol.104.007971, ISSN: 0026-895X.

Prusakiewicz JJ, Felts AS, Mackenzie BS, Marnett LJ. Molecular basis of the time-dependent inhibition of cyclooxygenases by indomethacin. Biochemistry. 2004 Dec 12/14/2004; 43(49): 15439-45. PMID: 15581355, DOI: 10.1021/bi048534q, ISSN: 0006-2960.

Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN, Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat. Med [print-electronic]. 2004 Oct; 10(10): 1074-80. PMID: 15378054, PII: nm1104, DOI: 10.1038/nm1104, ISSN: 1078-8956.

Hashim MF, Riggins JN, Schnetz-Boutaud N, Voehler M, Stone MP, Marnett LJ. In vitro bypass of malondialdehyde-deoxyguanosine adducts: differential base selection during extension by the Klenow fragment of DNA polymerase I is the critical determinant of replication outcome. Biochemistry. 2004 Sep 9/21/2004; 43(37): 11828-35. PMID: 15362868, DOI: 10.1021/bi049360f, ISSN: 0006-2960.

Riggins JN, Pratt DA, Voehler M, Daniels JS, Marnett LJ. Kinetics and mechanism of the general-acid-catalyzed ring-closure of the malondialdehyde-DNA adduct, N2-(3-oxo-1-propenyl)deoxyguanosine (N2OPdG-), to 3-(2'-Deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin- 10(3H)-one (M1dG). J. Am. Chem. Soc. 2004 Sep 9/1/2004; 126(34): 10571-81. PMID: 15327313, DOI: 10.1021/ja040010q, ISSN: 0002-7863.

Rouzer CA, Kingsley PJ, Wang H, Zhang H, Morrow JD, Dey SK, Marnett LJ. Cyclooxygenase-1-dependent prostaglandin synthesis modulates tumor necrosis factor-alpha secretion in lipopolysaccharide-challenged murine resident peritoneal macrophages. J. Biol. Chem [print-electronic]. 2004 Aug 8/13/2004; 279(33): 34256-68. PMID: 15181007, PII: M402594200, DOI: 10.1074/jbc.M402594200, ISSN: 0021-9258.

Riggins JN, Daniels JS, Rouzer CA, Marnett LJ. Kinetic and thermodynamic analysis of the hydrolytic ring-opening of the malondialdehyde-deoxyguanosine adduct, 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)- pyrimido[1,2-alpha]purin-10(3H)-one. J. Am. Chem. Soc. 2004 Jul 7/7/2004; 126(26): 8237-43. PMID: 15225065, DOI: 10.1021/ja040009r, ISSN: 0002-7863.

Cline SD, Riggins JN, Tornaletti S, Marnett LJ, Hanawalt PC. Malondialdehyde adducts in DNA arrest transcription by T7 RNA polymerase and mammalian RNA polymerase II. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 May 5/11/2004; 101(19): 7275-80. PMID: 15123825, PMCID: PMC409909, PII: 0402252101, DOI: 10.1073/pnas.0402252101, ISSN: 0027-8424.

West JD, Ji C, Duncan ST, Amarnath V, Schneider C, Rizzo CJ, Brash AR, Marnett LJ. Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation. Chem. Res. Toxicol. 2004 Apr; 17(4): 453-62. PMID: 15089087, DOI: 10.1021/tx034248o, ISSN: 0893-228X.

Nirodi CS, Crews BC, Kozak KR, Morrow JD, Marnett LJ. The glyceryl ester of prostaglandin E2 mobilizes calcium and activates signal transduction in RAW264.7 cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Feb 2/17/2004; 101(7): 1840-5. PMID: 14766978, PMCID: PMC357014, PII: 0303950101, DOI: 10.1073/pnas.0303950101, ISSN: 0027-8424.

Wang H, Marnett LJ, Harris TM, Rizzo CJ. A novel synthesis of malondialdehyde adducts of deoxyguanosine, deoxyadenosine, and deoxycytidine. Chem. Res. Toxicol. 2004 Feb; 17(2): 144-9. PMID: 14967001, DOI: 10.1021/tx034174g, ISSN: 0893-228X.

Kozak KR, Prusakiewicz JJ, Marnett LJ. Oxidative metabolism of endocannabinoids by COX-2. Curr. Pharm. Des. 2004; 10(6): 659-67. PMID: 14965328, ISSN: 1381-6128.

Remmel RP, Crews BC, Kozak KR, Kalgutkar AS, Marnett LJ. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab. Dispos. 2004 Jan; 32(1): 113-22. PMID: 14709628, PII: 32/1/113, DOI: 10.1124/dmd.32.1.113, ISSN: 0090-9556.

J.J. Prusakiewicz, A.S. Felts, B.S. Mackenzie, and L.J. Marnett.. Molecular Basis of the Time-Dependent Inhibition of Cyclooxygenases by Indomethacin. Biochemistry. 2004; 43: 15439-45.

K.R. Kozak, J.J. Prusakiewicz, S.W. Rowlinson, D.R. Prudhomme, and L.J. Marnett.. Amino Acid Determinants in Cyclooxygenase-2 Oxygenation of the Endocannabinoid Anandamide. Biochemistry. 2004; 42: 9041-9.

R.P. Remmel, B.C. Crews, K.R. Kozak, A.S. Kalgutkar, and L.J. Marnett.. Studies on the Metabolism of the Novel, Selective Cyclooxygenase-2 Inhibitor, Indomethacin Phenethylamide in Rat, Mouse, and Human Liver Microsomes: Identification of Active Metabolites. Drug Metab. Dispos. 2004; 32: 113-22.

VanderVeen LA, Hashim MF, Shyr Y, Marnett LJ. Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Nov 11/25/2003; 100(24): 14247-52. PMID: 14603032, PMCID: PMC283577, PII: 2332176100, DOI: 10.1073/pnas.2332176100, ISSN: 0027-8424.

Rowlinson SW, Kiefer JR, Prusakiewicz JJ, Pawlitz JL, Kozak KR, Kalgutkar AS, Stallings WC, Kurumbail RG, Marnett LJ. A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385. J. Biol. Chem [print-electronic]. 2003 Nov 11/14/2003; 278(46): 45763-9. PMID: 12925531, PII: M305481200, DOI: 10.1074/jbc.M305481200, ISSN: 0021-9258.

Niedernhofer LJ, Daniels JS, Rouzer CA, Greene RE, Marnett LJ. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J. Biol. Chem [print-electronic]. 2003 Aug 8/15/2003; 278(33): 31426-33. PMID: 12775726, PII: M212549200, DOI: 10.1074/jbc.M212549200, ISSN: 0021-9258.

Kozak KR, Prusakiewicz JJ, Rowlinson SW, Prudhomme DR, Marnett LJ. Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid anandamide. Biochemistry. 2003 Aug 8/5/2003; 42(30): 9041-9. PMID: 12885237, DOI: 10.1021/bi034471k, ISSN: 0006-2960.

Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR. The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Aug 8/5/2003; 100(16): 9162-7. PMID: 12881489, PMCID: PMC170889, PII: 1633612100, DOI: 10.1073/pnas.1633612100, ISSN: 0027-8424.

Rouzer CA, Marnett LJ. Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases. Chem. Rev. 2003 Jun; 103(6): 2239-304. PMID: 12797830, DOI: 10.1021/cr000068x, ISSN: 0009-2665.

Otteneder M, Daniels JS, Voehler M, Marnett LJ. Development of a method for determination of the malondialdehyde-deoxyguanosine adduct in urine using liquid chromatography-tandem mass spectrometry. Anal. Biochem. 2003 Apr 4/15/2003; 315(2): 147-51. PMID: 12689823, PII: S0003269702006978, ISSN: 0003-2697.

Kingsley PJ, Marnett LJ. Analysis of endocannabinoids by Ag+ coordination tandem mass spectrometry. Anal. Biochem. 2003 Mar 3/1/2003; 314(1): 8-15. PMID: 12633597, PII: S0003269702006437, ISSN: 0003-2697.

Marnett LJ, Riggins JN, West JD. Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein. J. Clin. Invest. 2003 Mar; 111(5): 583-93. PMID: 12618510, PMCID: PMC151910, DOI: 10.1172/JCI18022, ISSN: 0021-9738.

Aronoff DM, Boutaud O, Marnett LJ, Oates JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. J. Pharmacol. Exp. Ther. 2003 Feb; 304(2): 589-95. PMID: 12538810, DOI: 10.1124/jpet.102.042853, ISSN: 0022-3565.

Phillip Hochgesang G, Nemeth-Cawley JF, Rowlinson SW, Caprioli RM, Marnett LJ. Functional analysis of the molecular determinants of cyclooxygenase-2 acetylation by 2-acetoxyphenylhept-2-ynyl sulfide. Arch. Biochem. Biophys. 2003 Jan 1/1/2003; 409(1): 127-33. PMID: 12464251, PII: S0003986102005490, ISSN: 0003-9861.

Marnett LJ. Oxy radicals, lipid peroxidation and DNA damage. Toxicology. 2002 Dec 12/27/2002; 181-182: 219-22. PMID: 12505314, PII: S0300483X02004481, ISSN: 0300-483X.

Kozak KR, Crews BC, Morrow JD, Wang LH, Ma YH, Weinander R, Jakobsson PJ, Marnett LJ. Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J. Biol. Chem [print-electronic]. 2002 Nov 11/22/2002; 277(47): 44877-85. PMID: 12244105, PII: M206788200, DOI: 10.1074/jbc.M206788200, ISSN: 0021-9258.

Rouzer CA, Ghebreselasie K, Marnett LJ. Chemical stability of 2-arachidonylglycerol under biological conditions. Chem. Phys. Lipids. 2002 Oct; 119(1-2): 69-82. PMID: 12270674, PII: S0009308402000683, ISSN: 0009-3084.

Prusakiewicz JJ, Kingsley PJ, Kozak KR, Marnett LJ. Selective oxygenation of N-arachidonylglycine by cyclooxygenase-2. Biochem. Biophys. Res. Commun. 2002 Aug 8/23/2002; 296(3): 612-7. PMID: 12176025, PII: S0006291X02009154, ISSN: 0006-291X.

Moody JS, Marnett LJ. Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid. Biochemistry. 2002 Aug 8/13/2002; 41(32): 10297-303. PMID: 12162745, PII: bi020320q, ISSN: 0006-2960.

Marnett LJ. Recent developments in cyclooxygenase inhibition. Prostaglandins Other Lipid Mediat. 2002 Aug; 68-69: 153-64. PMID: 12432915, ISSN: 1098-8823.

Timofeevski SL, Prusakiewicz JJ, Rouzer CA, Marnett LJ. Isoform-selective interaction of cyclooxygenase-2 with indomethacin amides studied by real-time fluorescence, inhibition kinetics, and site-directed mutagenesis. Biochemistry. 2002 Jul 7/30/2002; 41(30): 9654-62. PMID: 12135387, PII: bi0203637, ISSN: 0006-2960.

Kozak KR, Gupta RA, Moody JS, Ji C, Boeglin WE, DuBois RN, Brash AR, Marnett LJ. 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. J. Biol. Chem [print-electronic]. 2002 Jun 6/28/2002; 277(26): 23278-86. PMID: 11956198, PII: M201084200, DOI: 10.1074/jbc.M201084200, ISSN: 0021-9258.

Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA. Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc. Natl. Acad. Sci. U.S.A. 2002 May 5/14/2002; 99(10): 7130-5. PMID: 12011469, PMCID: PMC124540, PII: 99/10/7130, DOI: 10.1073/pnas.102588199, ISSN: 0027-8424.

Kozak KR, Prusakiewicz JJ, Rowlinson SW, Marnett LJ. Enantiospecific, selective cyclooxygenase-2 inhibitors. Bioorg. Med. Chem. Lett. 2002 May 5/6/2002; 12(9): 1315-8. PMID: 11965379, PII: S0960894X02001336, ISSN: 0960-894X.

Burleigh ME, Babaev VR, Oates JA, Harris RC, Gautam S, Riendeau D, Marnett LJ, Morrow JD, Fazio S, Linton MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation. 2002 Apr 4/16/2002; 105(15): 1816-23. PMID: 11956125, ISSN: 1524-4539.

Plastaras JP, Dedon PC, Marnett LJ. Effects of DNA structure on oxopropenylation by the endogenous mutagens malondialdehyde and base propenal. Biochemistry. 2002 Apr 4/16/2002; 41(15): 5033-42. PMID: 11939800, PII: bi0113059, ISSN: 0006-2960.

Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML. Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. Free Radic. Biol. Med. 2002 Apr 4/1/2002; 32(7): 650-62. PMID: 11909699, PII: S0891584902007554, ISSN: 0891-5849.

Otteneder M, Plastaras JP, Marnett LJ. Reaction of malondialdehyde-DNA adducts with hydrazines-development of a facile assay for quantification of malondialdehyde equivalents in DNA. Chem. Res. Toxicol. 2002 Mar; 15(3): 312-8. PMID: 11896677, PII: tx010105v, ISSN: 0893-228X.

Kalgutkar AS, Rowlinson SW, Crews BC, Marnett LJ. Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors. Bioorg. Med. Chem. Lett. 2002 Feb 2/25/2002; 12(4): 521-4. PMID: 11844663, PII: S0960894X01007922, ISSN: 0960-894X.

Kozak KR, Marnett LJ. Oxidative metabolism of endocannabinoids. Prostaglandins Leukot. Essent. Fatty Acids. 2002 Feb; 66(2-3): 211-20. PMID: 12052037, PII: S095232780190359X, DOI: 10.1054/plef.2001.0359, ISSN: 0952-3278.

Weisenseel JP, Reddy GR, Marnett LJ, Stone MP. Structure of the 1,N(2)-propanodeoxyguanosine adduct in a three-base DNA hairpin loop derived from a palindrome in the Salmonella typhimurium hisD3052 gene. Chem. Res. Toxicol. 2002 Feb; 15(2): 140-52. PMID: 11849039, PII: tx010107f, ISSN: 0893-228X.

Weisenseel JP, Reddy GR, Marnett LJ, Stone MP. Structure of an oligodeoxynucleotide containing a 1,N(2)-propanodeoxyguanosine adduct positioned in a palindrome derived from the Salmonella typhimurium hisD3052 gene: Hoogsteen pairing at pH 5.2. Chem. Res. Toxicol. 2002 Feb; 15(2): 127-39. PMID: 11849038, PII: tx0101090, ISSN: 0893-228X.

Schneider C, Boeglin WE, Prusakiewicz JJ, Rowlinson SW, Marnett LJ, Samel N, Brash AR. Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349. J. Biol. Chem [print-electronic]. 2002 Jan 1/4/2002; 277(1): 478-85. PMID: 11677234, PII: M107471200, DOI: 10.1074/jbc.M107471200, ISSN: 0021-9258.

Marnett LJ, DuBois RN. COX-2: a target for colon cancer prevention. Annu. Rev. Pharmacol. Toxicol. 2002; 42: 55-80. PMID: 11807164, PII: 42/1/55, DOI: 10.1146/annurev.pharmtox.42.082301.164620, ISSN: 0362-1642.

L.J. Marnett. Oxy Radicals, Lipid Peroxidation and DNA Damage. Toxicology. 2002; 181-182: 219-22.

J.S. Moody and L.J. Marnett. Kinetics of Inhibition of Leukocyte 12-Lipoxygenase by the Isoform-Specific Inhibitor 4-(2-Oxapentadeca-4-yne)-phenylpropanoic Acid. Biochemistry. 2002; 41: 10297-303.

S.L. Timofeevski, J.J. Prusakiewicz, C.A. Rouzer, and L.J. Marnett.. Isoform-Selective Interaction of Cyclooxygenase-2 with Indomethacin Amides Studied by Real-Time Fluorescence, Inhibition Kinetics, and Site-Directed Mutagenesis. Biochemistry. 2002; 41: 9654-62.

A.S. Kalgutkar, S.W. Rowlinson, B.C. Crews, and L.J. Marnett.. Amide Derivatives of Meclofenamic Acid as Selective Cyclooxygenase-2 Inhibitors. Bioorg. Med. Chem. Lett. 2002; 12: 521-4.

C.A. Rouzer, K. Ghebreselasi, and L.J. Marnett. Chemical Stability of 2-Arachidonylglycerol under Biological Conditions. Chem. Phys. Lipids. 2002; 119: 69-82.

Schnetz-Boutaud NC, Saleh S, Marnett LJ, Stone MP. The exocyclic 1,N2-deoxyguanosine pyrimidopurinone M1G is a chemically stable DNA adduct when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene. Biochemistry. 2001 Dec 12/25/2001; 40(51): 15638-49. PMID: 11747439, PII: bi011242u, ISSN: 0006-2960.

Kurumbail RG, Kiefer JR, Marnett LJ. Cyclooxygenase enzymes: catalysis and inhibition. Curr. Opin. Struct. Biol. 2001 Dec; 11(6): 752-60. PMID: 11751058, PII: S0959-440X(01)00277-9, ISSN: 0959-440X.

Riggins JN, Marnett LJ. Mutagenicity of the malondialdehyde oligomerization products 2-(3'-oxo-1'-propenyl)-malondialdehyde and 2,4-dihydroxymethylene-3-(2,2-dimethoxyethyl)glutaraldehyde in Salmonella. Mutat. Res. 2001 Oct 10/18/2001; 497(1-2): 153-7. PMID: 11525918, PII: S1383571801002534, ISSN: 0027-5107.

Kozak KR, Crews BC, Ray JL, Tai HH, Morrow JD, Marnett LJ. Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo. J. Biol. Chem [print-electronic]. 2001 Oct 10/5/2001; 276(40): 36993-8. PMID: 11447235, PII: M105854200, DOI: 10.1074/jbc.M105854200, ISSN: 0021-9258.

Kozak KR, Prusakiewicz JJ, Rowlinson SW, Schneider C, Marnett LJ. Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol. J. Biol. Chem [print-electronic]. 2001 Aug 8/10/2001; 276(32): 30072-7. PMID: 11402053, PII: M104467200, DOI: 10.1074/jbc.M104467200, ISSN: 0021-9258.

Ji C, Amarnath V, Pietenpol JA, Marnett LJ. 4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release. Chem. Res. Toxicol. 2001 Aug; 14(8): 1090-6. PMID: 11511183, PII: tx000186f, ISSN: 0893-228X.

Boutaud O, Brame CJ, Chaurand P, Li J, Rowlinson SW, Crews BC, Ji C, Marnett LJ, Caprioli RM, Roberts LJ, Oates JA. Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry. 2001 Jun 6/12/2001; 40(23): 6948-55. PMID: 11389610, PII: bi002629k, ISSN: 0006-2960.

Ji C, Kozak KR, Marnett LJ. IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J. Biol. Chem [print-electronic]. 2001 May 5/25/2001; 276(21): 18223-8. PMID: 11359792, PII: M101266200, DOI: 10.1074/jbc.M101266200, ISSN: 0021-9258.

Schnetz-Boutaud NC, Chapeau MC, Marnett LJ. Enzymatic synthesis of M(1)G-deoxyribose. Curr Protoc Nucleic Acid Chem. 2001 May; Chapter 1: Unit1.2. PMID: 18428817, DOI: 10.1002/0471142700.nc0102s00, ISSN: 1934-9289.

Fink SP, Marnett LJ. The relative contribution of adduct blockage and DNA repair on template utilization during replication of 1,N2-propanodeoxyguanosine and pyrimido. Mutat. Res. 2001 Apr 4/4/2001; 485(3): 209-18. PMID: 11267832, PII: S0921877701000647, ISSN: 0027-5107.

Marnett LJ, Plastaras JP. Endogenous DNA damage and mutation. Trends Genet. 2001 Apr; 17(4): 214-21. PMID: 11275327, PII: S0168-9525(01)02239-9, ISSN: 0168-9525.

VanderVeen LA, Hashim MF, Nechev LV, Harris TM, Harris CM, Marnett LJ. Evaluation of the mutagenic potential of the principal DNA adduct of acrolein. J. Biol. Chem [print-electronic]. 2001 Mar 3/23/2001; 276(12): 9066-70. PMID: 11106660, PII: M008900200, DOI: 10.1074/jbc.M008900200, ISSN: 0021-9258.

Nemeth JF, Hochgesang GP, Marnett LJ, Caprioli RM. Characterization of the glycosylation sites in cyclooxygenase-2 using mass spectrometry. Biochemistry. 2001 Mar 3/13/2001; 40(10): 3109-16. PMID: 11258925, PII: bi002313c, ISSN: 0006-2960.

Moody JS, Kozak KR, Ji C, Marnett LJ. Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase. Biochemistry. 2001 Jan 1/30/2001; 40(4): 861-6. PMID: 11170406, PII: bi002303b, ISSN: 0006-2960.

Schnetz-Boutaud NC, Saleh S, Marnett LJ, Stone MP. Structure of the malondialdehyde deoxyguanosine adduct M1G when placed opposite a two-base deletion in the (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene. Adv. Exp. Med. Biol. 2001; 500: 513-6. PMID: 11764989, ISSN: 0065-2598.

Boutaud O, Li J, Chaurand P, Brame CJ, Marnett LJ, Roberts LJ, Oates JA. Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv. Exp. Med. Biol. 2001; 500: 133-7. PMID: 11764925, ISSN: 0065-2598.

K.R. Kozak, J.J. Prusakiewicz, S.W. Rowlinson, C. Schneider, and L.J. Marnett.. Amino Acid Determinants in Cyclooxygenase-2 Oxygenation of the Endocannabinoid 2-Arachidonyl-glycerol. J. Biol. Chem. 2001; 276: 30072-7.

Plastaras JP, Riggins JN, Otteneder M, Marnett LJ. Reactivity and mutagenicity of endogenous DNA oxopropenylating agents: base propenals, malondialdehyde, and N(epsilon)-oxopropenyllysine. Chem. Res. Toxicol. 2000 Dec; 13(12): 1235-42. PMID: 11123964, PII: tx0001631, ISSN: 0893-228X.

Kozak KR, Rowlinson SW, Marnett LJ. Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. J. Biol. Chem. 2000 Oct 10/27/2000; 275(43): 33744-9. PMID: 10931854, PII: M007088200, DOI: 10.1074/jbc.M007088200, ISSN: 0021-9258.

Schnetz-Boutaud N, Daniels JS, Hashim MF, Scholl P, Burrus T, Marnett LJ. Pyrimido[1,2-alpha]purin-10(3H)-one: a reactive electrophile in the genome. Chem. Res. Toxicol. 2000 Oct; 13(10): 967-70. PMID: 11080044, PII: tx000135i, ISSN: 0893-228X.

Marnett LJ. Cyclooxygenase mechanisms. Curr Opin Chem Biol. 2000 Oct; 4(5): 545-52. PMID: 11006543, PII: S1367-5931(00)00130-7, ISSN: 1367-5931.

Kalgutkar AS, Marnett AB, Crews BC, Remmel RP, Marnett LJ. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J. Med. Chem. 2000 Jul 7/27/2000; 43(15): 2860-70. PMID: 10956194, PII: jm000004e, ISSN: 0022-2623.

Lanzo CA, Sutin J, Rowlinson S, Talley J, Marnett LJ. Fluorescence quenching analysis of the association and dissociation of a diarylheterocycle to cyclooxygenase-1 and cyclooxygenase-2: dynamic basis of cyclooxygenase-2 selectivity. Biochemistry. 2000 May 5/23/2000; 39(20): 6228-34. PMID: 10821698, PII: bi992761o, ISSN: 0006-2960.

Goodwin DC, Rowlinson SW, Marnett LJ. Substitution of tyrosine for the proximal histidine ligand to the heme of prostaglandin endoperoxide synthase 2: implications for the mechanism of cyclooxygenase activation and catalysis. Biochemistry. 2000 May 5/9/2000; 39(18): 5422-32. PMID: 10820014, PII: bi992752f, ISSN: 0006-2960.

Marnett LJ, Wright TL, Crews BC, Tannenbaum SR, Morrow JD. Regulation of prostaglandin biosynthesis by nitric oxide is revealed by targeted deletion of inducible nitric-oxide synthase. J. Biol. Chem. 2000 May 5/5/2000; 275(18): 13427-30. PMID: 10788454, PII: 275/18/13427, ISSN: 0021-9258.

Plastaras JP, Guengerich FP, Nebert DW, Marnett LJ. Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. J. Biol. Chem. 2000 Apr 4/21/2000; 275(16): 11784-90. PMID: 10766802, ISSN: 0021-9258.

Rowlinson SW, Crews BC, Goodwin DC, Schneider C, Gierse JK, Marnett LJ. Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete. J. Biol. Chem. 2000 Mar 3/3/2000; 275(9): 6586-91. PMID: 10692466, ISSN: 0021-9258.

Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis. 2000 Mar; 21(3): 361-70. PMID: 10688856, ISSN: 0143-3334.

Schnetz-Boutaud NC, Mao H, Stone MP, Marnett LJ. Synthesis of oligonucleotides containing the alkali-labile pyrimidopurinone adduct, M(1)G. Chem. Res. Toxicol. 2000 Feb; 13(2): 90-5. PMID: 10688532, PII: tx990141i, ISSN: 0893-228X.

Kalgutkar AS, Crews BC, Rowlinson SW, Marnett AB, Kozak KR, Remmel RP, Marnett LJ. Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2000 Jan 1/18/2000; 97(2): 925-30. PMID: 10639181, PMCID: PMC15432, ISSN: 0027-8424.

Marnett LJ. Structure, function and inhibition of cyclo-oxygenases. Ernst Schering Res. Found. Workshop. 2000; (31): 65-83. PMID: 10943328, ISSN: 0947-6075.

Richards KM, Moody JS, Marnett LJ. Mechanism of inhibition of porcine leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid. Biochemistry. 1999 Dec 12/14/1999; 38(50): 16529-38. PMID: 10600114, PII: bi991336s, ISSN: 0006-2960.

Marnett LJ, Kalgutkar AS. Cyclooxygenase 2 inhibitors: discovery, selectivity and the future. Trends Pharmacol. Sci. 1999 Nov; 20(11): 465-9. PMID: 10542447, PII: S0165-6147(99)01385-1, ISSN: 0165-6147.

Montine TJ, Sidell KR, Crews BC, Markesbery WR, Marnett LJ, Roberts LJ, Morrow JD. Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology. 1999 Oct 10/22/1999; 53(7): 1495-8. PMID: 10534257, ISSN: 0028-3878.

Mao H, Reddy GR, Marnett LJ, Stone MP. Solution structure of an oligodeoxynucleotide containing the malondialdehyde deoxyguanosine adduct N2-(3-oxo-1-propenyl)-dG (ring-opened M1G) positioned in a (CpG)3 frameshift hotspot of the Salmonella typhimurium hisD3052 gene. Biochemistry. 1999 Oct 10/12/1999; 38(41): 13491-501. PMID: 10521256, PII: bi9910124, ISSN: 0006-2960.

Johnson KA, Mierzwa ML, Fink SP, Marnett LJ. MutS recognition of exocyclic DNA adducts that are endogenous products of lipid oxidation. J. Biol. Chem. 1999 Sep 9/17/1999; 274(38): 27112-8. PMID: 10480926, ISSN: 0021-9258.

Daniel TO, Liu H, Morrow JD, Crews BC, Marnett LJ. Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. Cancer Res. 1999 Sep 9/15/1999; 59(18): 4574-7. PMID: 10493510, ISSN: 0008-5472.

Rowlinson SW, Crews BC, Lanzo CA, Marnett LJ. The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region. J. Biol. Chem. 1999 Aug 8/13/1999; 274(33): 23305-10. PMID: 10438506, ISSN: 0021-9258.

Marnett LJ, Rowlinson SW, Goodwin DC, Kalgutkar AS, Lanzo CA. Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition. J. Biol. Chem. 1999 Aug 8/13/1999; 274(33): 22903-6. PMID: 10438452, ISSN: 0021-9258.

Goodwin DC, Landino LM, Marnett LJ. Effects of nitric oxide and nitric oxide-derived species on prostaglandin endoperoxide synthase and prostaglandin biosynthesis. FASEB J. 1999 Jul; 13(10): 1121-36. PMID: 10385604, ISSN: 0892-6638.

Mao H, Schnetz-Boutaud NC, Weisenseel JP, Marnett LJ, Stone MP. Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct. Proc. Natl. Acad. Sci. U.S.A. 1999 Jun 6/8/1999; 96(12): 6615-20. PMID: 10359760, PMCID: PMC21963, ISSN: 0027-8424.

Marnett LJ. Lipid peroxidation-DNA damage by malondialdehyde. Mutat. Res. 1999 Mar 3/8/1999; 424(1-2): 83-95. PMID: 10064852, PII: S0027-5107(99)00010-X, ISSN: 0027-5107.

Goodwin DC, Landino LM, Marnett LJ. Reactions of prostaglandin endoperoxide synthase with nitric oxide and peroxynitrite. Drug Metab. Rev. 1999 Feb; 31(1): 273-94. PMID: 10065376, DOI: 10.1081/DMR-100101918, ISSN: 0360-2532.

Kalgutkar AS, Crews BC, Rowlinson SW, Garner C, Marnett LJ. Discovery of a new class of selective cyclooxygenase-2 (COX-2) inhibitor that covalently modifies the isozyme. Adv. Exp. Med. Biol. 1999; 469: 139-43. PMID: 10667322, ISSN: 0065-2598.

Marnett LJ. Chemistry and biology of DNA damage by malondialdehyde. IARC Sci. Publ. 1999; (150): 17-27. PMID: 10626205, ISSN: 0300-5038.

Kalgutkar AS, Kozak KR, Crews BC, Hochgesang GP, Marnett LJ. Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. J. Med. Chem. 1998 Nov 11/19/1998; 41(24): 4800-18. PMID: 9822550, PII: jm980303s, DOI: 10.1021/jm980303s, ISSN: 0022-2623.

Marnett LJ, Kalgutkar AS. Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents. Curr Opin Chem Biol. 1998 Aug; 2(4): 482-90. PMID: 9736921, PII: S1367-5931(98)80124-5, ISSN: 1367-5931.

Ji C, Rouzer CA, Marnett LJ, Pietenpol JA. Induction of cell cycle arrest by the endogenous product of lipid peroxidation, malondialdehyde. Carcinogenesis. 1998 Jul; 19(7): 1275-83. PMID: 9683189, ISSN: 0143-3334.

Kalgutkar AS, Crews BC, Rowlinson SW, Garner C, Seibert K, Marnett LJ. Aspirin-like molecules that covalently inactivate cyclooxygenase-2. Science. 1998 May 5/22/1998; 280(5367): 1268-70. PMID: 9596581, ISSN: 0036-8075.

Langouët S, Mican AN, Müller M, Fink SP, Marnett LJ, Muhle SA, Guengerich FP. Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1, 2-a]purine. Biochemistry. 1998 Apr 4/14/1998; 37(15): 5184-93. PMID: 9548749, PII: bi972327r, DOI: 10.1021/bi972327r, ISSN: 0006-2960.

Goodwin DC, Gunther MR, Hsi LC, Crews BC, Eling TE, Mason RP, Marnett LJ. Nitric oxide trapping of tyrosyl radicals generated during prostaglandin endoperoxide synthase turnover. Detection of the radical derivative of tyrosine 385. J. Biol. Chem. 1998 Apr 4/10/1998; 273(15): 8903-9. PMID: 9535872, ISSN: 0021-9258.

Lanzo CA, Beechem JM, Talley J, Marnett LJ. Investigation of the binding of isoform-selective inhibitors to prostaglandin endoperoxide synthases using fluorescence spectroscopy. Biochemistry. 1998 Jan 1/6/1998; 37(1): 217-26. PMID: 9425042, PII: bi971691n, DOI: 10.1021/bi971691n, ISSN: 0006-2960.

Ji C, Marnett LJ, Pietenpol JA. Cell cycle re-entry following chemically-induced cell cycle synchronization leads to elevated p53 and p21 protein levels. Oncogene. 1997 Nov 11/27/1997; 15(22): 2749-53. PMID: 9401002, DOI: 10.1038/sj.onc.1201441, ISSN: 0950-9232.

Landino LM, Crews BC, Gierse JK, Hauser SD, Marnett LJ. Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation. J. Biol. Chem. 1997 Aug 8/22/1997; 272(34): 21565-74. PMID: 9261177, ISSN: 0021-9258.

Hashim MF, Schnetz-Boutaud N, Marnett LJ. Replication of template-primers containing propanodeoxyguanosine by DNA polymerase beta. Induction of base pair substitution and frameshift mutations by template slippage and deoxynucleoside triphosphate stabilization. J. Biol. Chem. 1997 Aug 8/8/1997; 272(32): 20205-12. PMID: 9242698, ISSN: 0021-9258.

Fink SP, Reddy GR, Marnett LJ. Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde. Proc. Natl. Acad. Sci. U.S.A. 1997 Aug 8/5/1997; 94(16): 8652-7. PMID: 9238032, PMCID: PMC23062, ISSN: 0027-8424.

Richards KM, Marnett LJ. Leukocyte 12-lipoxygenase: expression, purification, and investigation of the role of methionine residues in turnover-dependent inactivation and 5,8,11,14-eicosatetraynoic acid inhibition. Biochemistry. 1997 Jun 6/3/1997; 36(22): 6692-9. PMID: 9184149, PII: bi963051a, DOI: 10.1021/bi963051a, ISSN: 0006-2960.

Niedernhofer LJ, Riley M, Schnetz-Boutaud N, Sanduwaran G, Chaudhary AK, Reddy GR, Marnett LJ. Temperature-dependent formation of a conjugate between tris(hydroxymethyl)aminomethane buffer and the malondialdehyde-DNA adduct pyrimidopurinone. Chem. Res. Toxicol. 1997 May; 10(5): 556-61. PMID: 9168253, PII: tx960191c, DOI: 10.1021/tx960191c, ISSN: 0893-228X.

Johnson KA, Fink SP, Marnett LJ. Repair of propanodeoxyguanosine by nucleotide excision repair in vivo and in vitro. J. Biol. Chem. 1997 Apr 4/25/1997; 272(17): 11434-8. PMID: 9111054, ISSN: 0021-9258.

Rouzer CA, Chaudhary AK, Nokubo M, Ferguson DM, Reddy GR, Blair IA, Marnett LJ. Analysis of the malondialdehyde-2'-deoxyguanosine adduct pyrimidopurinone in human leukocyte DNA by gas chromatography/electron capture/negative chemical ionization/mass spectrometry. Chem. Res. Toxicol. 1997 Feb; 10(2): 181-8. PMID: 9049429, PII: tx9601216, DOI: 10.1021/tx9601216, ISSN: 0893-228X.

Smith CJ, Morrow JD, Roberts LJ, Marnett LJ. Induction of prostaglandin endoperoxide synthase-1 (COX-1) in a human promonocytic cell line by treatment with the differentiating agent TPA. Adv. Exp. Med. Biol. 1997; 400A: 99-106. PMID: 9547543, ISSN: 0065-2598.

Kalgutkar AS, Crews BC, Marnett LJ. Inactivation of prostaglandin endoperoxide synthase (PGHS) by N-(substituted)maleimides. Adv. Exp. Med. Biol. 1997; 407: 79-85. PMID: 9321935, ISSN: 0065-2598.

Landino LM, Crews BC, Timmons MD, Morrow JD, Marnett LJ. Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 1996 Dec 12/24/1996; 93(26): 15069-74. PMID: 8986765, PMCID: PMC26357, ISSN: 0027-8424.

Smith CJ, Marnett LJ. Effects of cysteine-to-serine mutations on structural and functional properties of prostaglandin endoperoxide synthase. Arch. Biochem. Biophys. 1996 Nov 11/15/1996; 335(2): 342-50. PMID: 8914931, PII: S0003-9861(96)90515-9, DOI: 10.1006/abbi.1996.0515, ISSN: 0003-9861.

Kalgutkar AS, Crews BC, Marnett LJ. Kinetics of the interaction of nonsteroidal antiinflammatory drugs with prostaglandin endoperoxide synthase-1 studied by limited proteolysis. Biochemistry. 1996 Jul 7/16/1996; 35(28): 9076-82. PMID: 8703911, PII: bi9605752, DOI: 10.1021/bi9605752, ISSN: 0006-2960.

Chaudhary AK, Reddy GR, Blair IA, Marnett LJ. Characterization of an N6-oxopropenyl-2'-deoxyadenosine adduct in malondialdehyde-modified DNA using liquid chromatography/electrospray ionization tandem mass spectrometry. Carcinogenesis. 1996 May; 17(5): 1167-70. PMID: 8640930, ISSN: 0143-3334.

Kalgutkar AS, Crews BC, Marnett LJ. Design, synthesis, and biochemical evaluation of N-substituted maleimides as inhibitors of prostaglandin endoperoxide synthases. J. Med. Chem. 1996 Apr 4/12/1996; 39(8): 1692-703. PMID: 8648609, PII: jm950872p, DOI: 10.1021/jm950872p, ISSN: 0022-2623.

Hashim MF, Marnett LJ. Sequence-dependent induction of base pair substitutions and frameshifts by propanodeoxyguanosine during in vitro DNA replication. J. Biol. Chem. 1996 Apr 4/12/1996; 271(15): 9160-5. PMID: 8621568, ISSN: 0021-9258.

Landino LM, Marnett LJ. Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. Biochemistry. 1996 Feb 2/27/1996; 35(8): 2637-43. PMID: 8611568, PII: bi952546h, DOI: 10.1021/bi952546h, ISSN: 0006-2960.

Fink SP, Reddy GR, Marnett LJ. Relative contribution of cytosine deamination and error-prone replication to the induction of propanodeoxyguanosine-->deoxyadenosine mutations in Escherichia coli. Chem. Res. Toxicol. 1996 Jan; 9(1): 277-83. PMID: 8924603, PII: tx950060w, DOI: 10.1021/tx950060w, ISSN: 0893-228X.

Reddy GR, Marnett LJ. Mechanism of reaction of beta-(aryloxy)acroleins with nucleosides. Chem. Res. Toxicol. 1996 Jan; 9(1): 12-5. PMID: 8924580, PII: tx950105t, DOI: 10.1021/tx950105t, ISSN: 0893-228X.

Kingma PS, Corbett AH, Burcham PC, Marnett LJ, Osheroff N. Abasic sites stimulate double-stranded DNA cleavage mediated by topoisomerase II. DNA lesions as endogenous topoisomerase II poisons. J. Biol. Chem. 1995 Sep 9/15/1995; 270(37): 21441-4. PMID: 7665552, ISSN: 0021-9258.

Marnett LJ. Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer. Prev Med. 1995 Mar; 24(2): 103-6. PMID: 7597006, PII: S0091-7435(85)71017-1, DOI: 10.1006/pmed.1995.1017, ISSN: 0091-7435.

Weisenseel JP, Moe JG, Reddy GR, Marnett LJ, Stone MP. Structure of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frame shift hotspot of Salmonella typhimurium hisD3052 determined by 1H NMR and restrained molecular dynamics. Biochemistry. 1995 Jan 1/10/1995; 34(1): 50-64. PMID: 7819223, ISSN: 0006-2960.

Marnett LJ, Wilcox AL. The chemistry of lipid alkoxyl radicals and their role in metal-amplified lipid peroxidation. Biochem. Soc. Symp. 1995; 61: 65-72. PMID: 8660404, ISSN: 0067-8694.

Benamira M, Johnson K, Chaudhary A, Bruner K, Tibbetts C, Marnett LJ. Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escherichia coli: determination of the extent of DNA modification, genetic requirements for mutagenesis, and types of mutations induced. Carcinogenesis. 1995 Jan; 16(1): 93-9. PMID: 7834810, ISSN: 0143-3334.

Beckman JK, Bagheri F, Ji C, Blair IA, Marnett LJ. Phospholipid peroxidation in tumor promoter-exposed mouse skin. Carcinogenesis. 1994 Dec; 15(12): 2937-44. PMID: 8001259, ISSN: 0143-3334.

Marnett LJ. Generation of mutagens during arachidonic acid metabolism. Cancer Metastasis Rev. 1994 Dec; 13(3-4): 303-8. PMID: 7712592, ISSN: 0167-7659.

Marnett LJ, Honn KV. Overview of articles on eicosanoids and cancer. Cancer Metastasis Rev. 1994 Dec; 13(3-4): 237-9. PMID: 7712586, ISSN: 0167-7659.

Reddy RG, Yoshimoto T, Yamamoto S, Marnett LJ. Expression, purification, and characterization of porcine leukocyte 12-lipoxygenase produced in the methylotrophic yeast, Pichia pastoris. Biochem. Biophys. Res. Commun. 1994 Nov 11/30/1994; 205(1): 381-8. PMID: 7999053, PII: S0006-291X(84)72676-3, DOI: 10.1006/bbrc.1994.2676, ISSN: 0006-291X.

Burcham PC, Marnett LJ. Site-specific mutagenesis by a propanodeoxyguanosine adduct carried on an M13 genome. J. Biol. Chem. 1994 Nov 11/18/1994; 269(46): 28844-50. PMID: 7961843, ISSN: 0021-9258.

Kennedy TA, Smith CJ, Marnett LJ. Investigation of the role of cysteines in catalysis by prostaglandin endoperoxide synthase. J. Biol. Chem. 1994 Nov 11/4/1994; 269(44): 27357-64. PMID: 7961646, ISSN: 0021-9258.

Chaudhary AK, Nokubo M, Reddy GR, Yeola SN, Morrow JD, Blair IA, Marnett LJ. Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Science. 1994 Sep 9/9/1994; 265(5178): 1580-2. PMID: 8079172, ISSN: 0036-8075.

Chaudhary AK, Nokubo M, Marnett LJ, Blair IA. Analysis of the malondialdehyde-2'-deoxyguanosine adduct in rat liver DNA by gas chromatography/electron capture negative chemical ionization mass spectrometry. Biol. Mass Spectrom. 1994 Aug; 23(8): 457-64. PMID: 7918689, DOI: 10.1002/bms.1200230802, ISSN: 1052-9306.

Kalgutkar AS, Marnett LJ. Rapid inactivation of prostaglandin endoperoxide synthases by N-(carboxyalkyl)maleimides. Biochemistry. 1994 Jul 7/26/1994; 33(29): 8625-8. PMID: 8038151, ISSN: 0006-2960.

Reddy RG, Yoshimoto T, Yamamoto S, Funk CD, Marnett LJ. Expression of porcine leukocyte 12-lipoxygenase in a baculovirus/insect cell system and its characterization. Arch. Biochem. Biophys. 1994 Jul; 312(1): 219-26. PMID: 8031130, PII: S0003-9861(84)71302-6, DOI: 10.1006/abbi.1994.1302, ISSN: 0003-9861.

Moe JG, Reddy GR, Marnett LJ, Stone MP. 1H NMR characterization of a duplex oligodeoxynucleotide containing propanodeoxyguanosine opposite a two-base deletion in the (CpG)3 frameshift hotspot of Salmonella typhimurium hisD3052. Chem. Res. Toxicol. 1994 May; 7(3): 319-28. PMID: 8075363, ISSN: 0893-228X.

Marnett LJ, Ji C. Modulation of oxidant formation in mouse skin in vivo by tumor-promoting phorbol esters. Cancer Res. 1994 Apr 4/1/1994; 54(7 Suppl): 1886s-1889s. PMID: 8137305, ISSN: 0008-5472.

Marnett LJ. DNA adducts of alpha,beta-unsaturated aldehydes and dicarbonyl compounds. IARC Sci. Publ. 1994; (125): 151-63. PMID: 7806310, ISSN: 0300-5038.

Singh US, Moe JG, Reddy GR, Weisenseel JP, Marnett LJ, Stone MP. 1H NMR of an oligodeoxynucleotide containing a propanodeoxyguanosine adduct positioned in a (CG)3 frameshift hotspot of Salmonella typhimurium hisD3052: Hoogsteen base-pairing at pH 5.8. Chem. Res. Toxicol. 1993 Nov; 6(6): 825-36. PMID: 8117922, ISSN: 0893-228X.

Marnett LJ, Burcham PC. Endogenous DNA adducts: potential and paradox. Chem. Res. Toxicol. 1993 Nov; 6(6): 771-85. PMID: 8117915, ISSN: 0893-228X.

Wilcox AL, Marnett LJ. Polyunsaturated fatty acid alkoxyl radicals exist as carbon-centered epoxyallylic radicals: a key step in hydroperoxide-amplified lipid peroxidation. Chem. Res. Toxicol. 1993 Jul; 6(4): 413-6. PMID: 8374035, ISSN: 0893-228X.

Benamira M, Marnett LJ. Construction of a vector for site-specific frameshift mutagenesis containing the mutable hotspot of Salmonella typhimurium TA98 on an M13 bacteriophage. Chem. Res. Toxicol. 1993 May; 6(3): 317-27. PMID: 8318654, ISSN: 0893-228X.

Smith CJ, Morrow JD, Roberts LJ, Marnett LJ. Differentiation of monocytoid THP-1 cells with phorbol ester induces expression of prostaglandin endoperoxide synthase-1 (COX-1). Biochem. Biophys. Res. Commun. 1993 Apr 4/30/1993; 192(2): 787-93. PMID: 8484784, PII: S0006-291X(83)71483-X, DOI: 10.1006/bbrc.1993.1483, ISSN: 0006-291X.

Wells I, Marnett LJ. Inactivation of prostaglandin endoperoxide synthase by acylating derivatives of indomethacin. Biochemistry. 1993 Mar 3/16/1993; 32(10): 2710-6. PMID: 8448128, ISSN: 0006-2960.

Benamira M, Singh U, Marnett LJ. Site-specific frameshift mutagenesis by a propanodeoxyguanosine adduct positioned in the (CpG)4 hot-spot of Salmonella typhimurium hisD3052 carried on an M13 vector. J. Biol. Chem. 1992 Nov 11/5/1992; 267(31): 22392-400. PMID: 1429591, ISSN: 0021-9258.

Jajoo HK, Burcham PC, Goda Y, Blair IA, Marnett LJ. A thermospray liquid chromatography/mass spectrometry method for analysis of human urine for the major malondialdehyde-guanine adduct. Chem. Res. Toxicol. 1992 Nov; 5(6): 870-5. PMID: 1489939, ISSN: 0893-228X.

Benamira M, Marnett LJ. The lipid peroxidation product 4-hydroxynonenal is a potent inducer of the SOS response. Mutat. Res. 1992 Nov; 293(1): 1-10. PMID: 1383804, ISSN: 0027-5107.

Marnett LJ. Aspirin and the potential role of prostaglandins in colon cancer. Cancer Res. 1992 Oct 10/15/1992; 52(20): 5575-89. PMID: 1394181, ISSN: 0008-5472.

Wells I, Marnett LJ. Acetylation of prostaglandin endoperoxide synthase by N-acetylimidazole: comparison to acetylation by aspirin. Biochemistry. 1992 Oct 10/13/1992; 31(40): 9520-5. PMID: 1390734, ISSN: 0006-2960.

Ji C, Marnett LJ. Oxygen radical-dependent epoxidation of (7S,8S)-dihydroxy-7,8-dihydrobenzo[a]pyrene in mouse skin in vivo. Stimulation by phorbol esters and inhibition by antiinflammatory steroids. J. Biol. Chem. 1992 Sep 9/5/1992; 267(25): 17842-8. PMID: 1325452, ISSN: 0021-9258.

Odenwaller R, Maddipati KR, Marnett LJ. Detection of a higher oxidation state of manganese-prostaglandin endoperoxide synthase. J. Biol. Chem. 1992 Jul 7/15/1992; 267(20): 13863-9. PMID: 1321128, ISSN: 0021-9258.

Pal I, Odenwaller R, Marnett LJ. 7-Oxabicycloheptylprostanoic acids: potent, time-dependent cyclooxygenase inhibitors that induce a conformational change in the prostaglandin endoperoxide synthase protein. J. Med. Chem. 1992 Jun 6/12/1992; 35(12): 2340-2. PMID: 1613757, ISSN: 0022-2623.

Chapeau MC, Marnett LJ. Enzymatic synthesis of purine deoxynucleoside adducts. Chem. Res. Toxicol. 1991 Nov; 4(6): 636-8. PMID: 1807446, ISSN: 0893-228X.

Goda Y, Marnett LJ. High-performance liquid chromatography with electrochemical detection for determination of the major malondialdehyde-guanine adduct. Chem. Res. Toxicol. 1991 Sep; 4(5): 520-4. PMID: 1793799, ISSN: 0893-228X.

Marnett LJ. Peroxyl free radicals: biological reactive intermediates produced during lipid oxidation. Adv. Exp. Med. Biol. 1991; 283: 65-70. PMID: 2069034, ISSN: 0065-2598.

Odenwaller R, O'Gara CY, Marnett LJ. Properties of trypsin-cleaved PGH synthase. Adv. Prostaglandin Thromboxane Leukot. Res. 1991; 21A: 81-4. PMID: 1847786, ISSN: 0732-8141.

Marnett LJ, Leithauser MT, Richards KM, Blair I, Honn KV, Yamamoto S, Yoshimoto T. Arachidonic acid metabolism of cytosolic fractions of Lewis lung carcinoma cells. Adv. Prostaglandin Thromboxane Leukot. Res. 1991; 21B: 895-900. PMID: 1825434, ISSN: 0732-8141.

Stone K, Uzieblo A, Marnett LJ. Studies of the reaction of malondialdehyde with cytosine nucleosides. Chem. Res. Toxicol. 1990 Sep; 3(5): 467-72. PMID: 2133098, ISSN: 0893-228X.

Marnett LJ. Prostaglandin synthase-mediated metabolism of carcinogens and a potential role for peroxyl radicals as reactive intermediates. Environ. Health Perspect. 1990 Aug; 88: 5-12. PMID: 2125560, PMCID: PMC1568014, ISSN: 0091-6765.

Marnett LJ, Reddy A, Pruess-Schwartz D, Ji C. Oxidation of polycyclic hydrocarbons by oxygen radicals. Int. Symp. Princess Takamatsu Cancer Res. Fund. 1990; 21: 63-73. PMID: 2134691.

Shimada T, Martin MV, Pruess-Schwartz D, Marnett LJ, Guengerich FP. Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Res. 1989 Nov 11/15/1989; 49(22): 6304-12. PMID: 2509067, ISSN: 0008-5472.

Capdevila J, Gil L, Orellana M, Marnett LJ, Mason JI, Yadagiri P, Falck JR. Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Arch. Biochem. Biophys. 1988 Mar; 261(2): 257-63. PMID: 3128168, ISSN: 0003-9861.