Knowles A. Overholser, Ph.D.

Professor

k.a.overholser@vanderbilt.edu
Faculty Appointments
Professor of Biomedical Engineering and Chemical Engineering
Education
Ph.D., Chemical Engineering, University of Wisconsin, Madison, WisconsinM.S., Chemical Engineering, University of Wisconsin, Madison, WisconsinB.E., Chemical Engineering, Vanderbilt University, Nashville, Tennessee
Office Address
5332 Stevenson Center (Science & Engineering)
TN
Research Description
This work concentrates on fluid mechanics and mass transfer in the heart and in the lung, and in particular on effects of exercise training on coronary and cardiac function. The exercise work is performed in collaboration with investigators in radiology and in the Kim Dayani Center for Human Performance. The studies are motivated by the hypothesis that chronic exercise alters coronary flow distribution as well as the pumping function of the heart. They involve MR and PET imaging of the heart before and after exercise training in miniature pigs as well as in human subjects. We are also engaged with other collaborators in development of computer models of the pulmonary circulation and in the experimental study of the recruitment of functioning capillary surface area in the lung.

Current Projects Include:

Exercise training and its effect on the coronary circulation in miniature swine. Effects of exercise training on cardiac function and coronary flow distribution in healthy adults. Pressure-flow models of the pulmonary circulation. Recruitment of pulmonary capillary surface area.
Research Keywords
Cardiovascular and exercise physiology
Publications
Caruthers SD, Harris TR, Overholser KA, Pou NA, Parker RE. Effects of flow heterogeneity on the measurement of capillary exchange in the lung. J. Appl. Physiol. 1995 Nov; 79(5): 1449-60. PMID: 8594000, ISSN: 8750-7587.

Tack G, Roselli RJ, Overholser KA, Harris TR. The use of microsoft excel as a user interface for biological simulations. Comput. Biomed. Res. 1995 Feb; 28(1): 24-37. PMID: 7614822, PII: S0010480985710038, ISSN: 0010-4809.

Harris PA, Bosan S, Harris TR, Laughlin MH, Overholser KA. Parameter identification in coronary pressure flow models: a graphical approach. Ann Biomed Eng. 1994 Nov; 22(6): 622-37. PMID: 7872572, ISSN: 0090-6964.

Overholser KA, Laughlin MH, Bhatte MJ. Exercise training-induced increase in coronary transport capacity. Med Sci Sports Exerc. 1994 Oct; 26(10): 1239-44. PMID: 7799767, ISSN: 0195-9131.

Overholser KA, Lomangino NA, Parker RE, Pou NA, Harris TR. Pulmonary vascular resistance distribution and recruitment of microvascular surface area. J. Appl. Physiol. 1994 Aug; 77(2): 845-55. PMID: 8002538, ISSN: 8750-7587.

Overholser KA, Lomangino NA, Harris TR, Bradley JD, Bosan S. Deduction of pulmonary microvascular hematocrit from indicator dilution curves. Bull. Math. Biol. 1994 Mar; 56(2): 225-47. PMID: 8186753, PII: S0092-8240(05)80257-5, ISSN: 0092-8240.

Overholser, K.A., Lomangino, N.A., Harris, T.R., Bradley, J.D., and Bosan, S. Deduction of pulmonary microvascular hematocrit from indicator dilution curves. 1994.

1994; Available from: .

1994; Available from: .

Gilroy RJ, Bhatte MJ, Wickersham NE, Pou NA, Loyd JE, Overholser KA. Postischemic hypoperfusion during unilateral lung reperfusion in vivo. Am. Rev. Respir. Dis. 1993 Feb; 147(2): 276-82. PMID: 8430948, DOI: 10.1164/ajrccm/147.2.276, ISSN: 0003-0805.

Gilroy, R. J., Bhatte, M. J., Wickersham, N. E., Pou, N. A., Loyd, J. E., and Overholser, K. A. Postischemic hypoperfusion occurs during unilateral lung reperfusion in vivo. 1993.

Waters CM, Overholser KA, Sorkin A, Carpenter G. Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism. J. Cell. Physiol. 1992 Aug; 152(2): 253-63. PMID: 1639860, DOI: 10.1002/jcp.1041520206, ISSN: 0021-9541.

Waters, C. M., Overholser, K. A., Sorkin, A., and Carpenter, G. Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism. 1992.

Overholser KA, Bhatte MJ, Laughlin MH. Modeling the effect of flow heterogeneity on coronary permeability-surface area. J. Appl. Physiol. 1991 Aug; 71(2): 758-69. PMID: 1938750, ISSN: 8750-7587.

Sorkin A, Waters C, Overholser KA, Carpenter G. Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis. J. Biol. Chem. 1991 May 5/5/1991; 266(13): 8355-62. PMID: 2022651, ISSN: 0021-9258.

Overholser, K. A., Bhatte, M. J., and Laughlin, M. H. Modeling the effect of flow heterogeneity on coronary permeability-surface area. 1991.

Sorkin, A., Walters, C., Overholser, K. A., and Carpenter, G. Multiple autophosphorylation site mutations of the epidermal growth factor receptor: analysis of kinase activity and endocytosis. 1991.

Bradley JD, Parker RE, Harris TR, Overholser KA. Effects of ligation and embolization on Kf and multiple tracer measurements in dog lungs. J. Appl. Physiol. 1990 Oct; 69(4): 1460-6. PMID: 2262470, ISSN: 8750-7587.

Waters CM, Oberg KC, Carpenter G, Overholser KA. Rate constants for binding, dissociation, and internalization of EGF: effect of receptor occupancy and ligand concentration. Biochemistry. 1990 Apr 4/10/1990; 29(14): 3563-9. PMID: 2354152, ISSN: 0006-2960.