Todd E. Peterson, Ph.D.

Associate Professor

todd.e.peterson@vanderbilt.edu

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Faculty Appointments
Associate Professor of Radiology and Radiological Sciences Associate Professor of Physics
Education
Ph.D., Physics, Indiana University, Bloomington, IndianaM.S., Physics, Indiana University, Bloomington, IndianaB.A., University of Oxford, Oxford, United KingdomB.A., Gustavus Adolphus College, Saint Peter, Minnesota
Office Address
1161 21st Avenue South
MCN AA-1105
Nashville, TN 37232-2310
Research Description
Todd Peterson, Ph.D., earned M.S. and Ph.D. in Physics from Indiana University Bloomington. Following three years as a Postdoctoral Research at the Center for Gamma-Ray Imaging, University of Arizona, he joined the Vanderbilt faculty as Assistant Professor and Director of Nuclear Imaging in the Vanderbilt University Institute of Imaging Science. He was promoted to Associate Professor in 2012. From 2010 to 2017, he also served as Faculty Directory for the Office of Honor Scholarships. Dr. Peterson's research interests extend from the development of semiconductor radiation detectors for high-resolution nuclear imaging to preclinical and clinical applications of PET, SPECT, and CT imaging in oncology, pharmacology, and diabetes.

Section: Vanderbilt University Institute of Imaging Science
Research Keywords
Molecular Imaging, SPECT, nuclear imaging, radiation detection, microPET, microCT, PET/CT
Publications
Tantawy MN, Charles Manning H, Peterson TE, Colvin DC, Gore JC, Lu W, Chen Z, Chad Quarles C. Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model. Mol Imaging Biol [print-electronic]. 2017 Aug 8/18/2017; PMID: 28822038, PII: 10.1007/s11307-017-1113-7, DOI: 10.1007/s11307-017-1113-7, ISSN: 1860-2002.

Johnson LC, Ovchinnikov O, Shokouhi S, Peterson TE. Development of a Germanium Small-Animal SPECT System. IEEE Trans Nucl Sci [print-electronic]. 2015 Oct; 2015: 2036-42. PMID: 26755832, PMCID: PMC4706230, DOI: 10.1109/TNS.2015.2448673, ISSN: 0018-9499.

Han W, Zaynagetdinov R, Yull FE, Polosukhin VV, Gleaves LA, Tanjore H, Young LR, Peterson TE, Manning HC, Prince LS, Blackwell TS. Molecular imaging of folate receptor ß-positive macrophages during acute lung inflammation. Am. J. Respir. Cell Mol. Biol. 2015 Jul; 53(1): 50-9. PMID: 25375039, PMCID: PMC4566110, DOI: 10.1165/rcmb.2014-0289OC, ISSN: 1535-4989.

Felix DD, Gore JC, Yankeelov TE, Peterson TE, Barnes S, Whisenant J, Weis J, Shoukouhi S, Virostko J, Nickels M, McIntyre JO, Sanders M, Abramson V, Tantawy MN. Detection of breast cancer microcalcification using (99m)Tc-MDP SPECT or Osteosense 750EX FMT imaging. Nucl. Med. Biol [print-electronic]. 2015 Mar; 42(3): 269-73. PMID: 25533764, PMCID: PMC4889014, PII: S0969-8051(14)00549-6, DOI: 10.1016/j.nucmedbio.2014.11.010, ISSN: 1872-9614.

Whisenant JG, McIntyre JO, Peterson TE, Kang H, Sánchez V, Manning HC, Arteaga CL, Yankeelov TE. Utility of [18¿F]FLT-PET to assess treatment response in trastuzumab-resistant and trastuzumab-sensitive HER2-overexpressing human breast cancer xenografts. Mol Imaging Biol. 2015 Feb; 17(1): 119-28. PMID: 25034624, PMCID: PMC4311727, DOI: 10.1007/s11307-014-0770-z, ISSN: 1860-2002.

Campbell DL, Peterson TE. Simulation study comparing high-purity germanium and cadmium zinc telluride detectors for breast imaging. Phys Med Biol [print-electronic]. 2014 Nov 11/21/2014; 59(22): 7059-79. PMID: 25360792, PMCID: PMC4237407, DOI: 10.1088/0031-9155/59/22/7059, ISSN: 1361-6560.

Wilson GH, Gore JC, Yankeelov TE, Barnes S, Peterson TE, True JM, Shokouhi S, McIntyre JO, Sanders M, Abramson V, Ngyuen TQ, Mahadevan-Jansen A, Tantawy MN. An Approach to Breast Cancer Diagnosis via PET Imaging of Microcalcifications Using (18)F-NaF. J. Nucl. Med [print-electronic]. 2014 Jul; 55(7): 1138-43. PMID: 24833491, PMCID: PMC4320039, PII: jnumed.114.139170, DOI: 10.2967/jnumed.114.139170, ISSN: 1535-5667.

Lee HJ, Luci JJ, Tantawy MN, Lee H, Nam KT, Peterson TE, Price RR. Detecting peritoneal dissemination of ovarian cancer in mice by DWIBS. Magn Reson Imaging [print-electronic]. 2013 Feb; 31(2): 227-34. PMID: 22925604, PMCID: PMC3740967, PII: S0730-725X(12)00226-3, DOI: 10.1016/j.mri.2012.06.016, ISSN: 1873-5894.

Whisenant JG, Peterson TE, Fluckiger JU, Tantawy MN, Ayers GD, Yankeelov TE. Reproducibility of static and dynamic (18)F-FDG, (18)F-FLT, and (18)F-FMISO MicroPET studies in a murine model of HER2+ breast cancer. Mol Imaging Biol. 2013 Feb; 15(1): 87-96. PMID: 22644988, PMCID: PMC3752931, DOI: 10.1007/s11307-012-0564-0, ISSN: 1860-2002.

Tantawy MN, Jiang R, Wang F, Takahashi K, Peterson TE, Zemel D, Hao CM, Fujita H, Harris RC, Quarles CC, Takahashi T. Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy. BMC Nephrol. 2012 Dec 12/10/2012; 13: 168. PMID: 23228112, PMCID: PMC3542003, PII: 1471-2369-13-168, DOI: 10.1186/1471-2369-13-168, ISSN: 1471-2369.

Skinner JT, Yankeelov TE, Peterson TE, Does MD. Comparison of dynamic contrast-enhanced MRI and quantitative SPECT in a rat glioma model. Contrast Media Mol Imaging. 2012 Nov; 7(6): 494-500. PMID: 22991315, PMCID: PMC3458584, DOI: 10.1002/cmmi.1479, ISSN: 1555-4317.

Yankeelov TE, Peterson TE, Abramson RG, Izquierdo-Garcia D, Arlinghaus LR, Li X, Atuegwu NC, Catana C, Manning HC, Fayad ZA, Gore JC. Simultaneous PET-MRI in oncology: a solution looking for a problem?. Magn Reson Imaging [print-electronic]. 2012 Nov; 30(9): 1342-56. PMID: 22795930, PMCID: PMC3466373, PII: S0730-725X(12)00199-3, DOI: 10.1016/j.mri.2012.06.001, ISSN: 1873-5894.

Peterson TE, Shokouhi S. Advances in preclinical SPECT instrumentation. J. Nucl. Med [print-electronic]. 2012 Jun; 53(6): 841-4. PMID: 22586145, PMCID: PMC3422073, PII: jnumed.111.099853, DOI: 10.2967/jnumed.111.099853, ISSN: 1535-5667.

Tang D, Hight MR, McKinley ET, Fu A, Buck JR, Smith RA, Tantawy MN, Peterson TE, Colvin DC, Ansari MS, Nickels M, Manning HC. Quantitative preclinical imaging of TSPO expression in glioma using N,N-diethyl-2-(2-(4-(2-18F-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)acetamide. J. Nucl. Med [print-electronic]. 2012 Feb; 53(2): 287-94. PMID: 22251555, PMCID: PMC3391587, PII: jnumed.111.095653, DOI: 10.2967/jnumed.111.095653, ISSN: 1535-5667.

Nolting DD, Nickels M, Tantawy MN, Yu JY, Xie J, Peterson TE, Crews BC, Marnett L, Gore JC, Pham W. Convergent synthesis and evaluation of (18)F-labeled azulenic COX2 probes for cancer imaging. Front Oncol. 2012; 2: 207. PMID: 23316477, PMCID: PMC3539664, DOI: 10.3389/fonc.2012.00207, ISSN: 2234-943X.

Virostko J, Henske J, Vinet L, Lamprianou S, Dai C, Radhika A, Baldwin RM, Ansari MS, Hefti F, Skovronsky D, Kung HF, Herrera PL, Peterson TE, Meda P, Powers AC. Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Dec 12/20/2011; 108(51): 20719-24. PMID: 22143775, PMCID: PMC3251115, PII: 1109480108, DOI: 10.1073/pnas.1109480108, ISSN: 1091-6490.

Tantawy MN, Peterson TE, Jones CK, Johnson K, Rook JM, Conn PJ, Baldwin RM, Ansari MS, Kessler RM. Impact of isoflurane anesthesia on D2 receptor occupancy by [18F]fallypride measured by microPET with a modified Logan plot. Synapse [print-electronic]. 2011 Nov; 65(11): 1173-80. PMID: 21584868, PMCID: PMC4078917, DOI: 10.1002/syn.20955, ISSN: 1098-2396.

Johnson LC, Campbell DL, Hull EL, Peterson TE. Characterization of a high-purity germanium detector for small-animal SPECT. Phys Med Biol [print-electronic]. 2011 Sep 9/21/2011; 56(18): 5877-88. PMID: 21852723, PMCID: PMC3178965, PII: S0031-9155(11)93927-X, DOI: 10.1088/0031-9155/56/18/007, ISSN: 1361-6560.

Peterson TE, Furenlid LR. SPECT detectors: the Anger Camera and beyond. Phys Med Biol [print-electronic]. 2011 Sep 9/7/2011; 56(17): R145-82. PMID: 21828904, PMCID: PMC3178269, PII: S0031-9155(11)17550-8, DOI: 10.1088/0031-9155/56/17/R01, ISSN: 1361-6560.

Durko HL, Peterson TE, Barrett HH, Furenlid LR. High-resolution, anamorphic, adaptive small-animal SPECT imaging with silicon double-sided strip detectors. Proc SPIE Int Soc Opt Eng. 2011 Aug 8/21/2011; 8143: PMID: 26346619, PMCID: PMC4558916, DOI: 10.1117/12.896729, ISSN: 0277-786X.

Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis Model Mech [print-electronic]. 2011 May; 4(3): 359-67. PMID: 21282722, PMCID: PMC3097457, PII: dmm.005793, DOI: 10.1242/dmm.005793, ISSN: 1754-8411.

Lee HJ, Tantawy MN, Nam KT, Choi I, Peterson TE, Price RR. Evaluation of an intraperitoneal ovarian cancer syngeneic mouse model using 18F-FDG MicroPET imaging. Int. J. Gynecol. Cancer. 2011 Jan; 21(1): 22-7. PMID: 21321526, PII: 00009577-201101000-00005, DOI: 10.1097/IGC.0b013e3182021bda, ISSN: 1525-1438.

Buck JR, McKinley ET, Hight MR, Fu A, Tang D, Smith RA, Tantawy MN, Peterson TE, Colvin D, Ansari MS, Baldwin RM, Zhao P, Guleryuz S, Manning HC. Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline. J. Nucl. Med [print-electronic]. 2011 Jan; 52(1): 107-14. PMID: 21149488, PMCID: PMC3027353, PII: jnumed.110.081703, DOI: 10.2967/jnumed.110.081703, ISSN: 1535-5667.

Johnson LC, Johnson RW, Munoz SA, Mundy GR, Peterson TE, Sterling JA. Longitudinal live animal micro-CT allows for quantitative analysis of tumor-induced bone destruction. Bone [print-electronic]. 2011 Jan; 48(1): 141-51. PMID: 20685406, PMCID: PMC2974944, PII: S8756-3282(10)01284-6, DOI: 10.1016/j.bone.2010.05.033, ISSN: 1873-2763.

Shokouhi S, Wilson DW, Metzler SD, Peterson TE. Evaluation of image reconstruction for mouse brain imaging with synthetic collimation from highly multiplexed SiliSPECT projections. Phys Med Biol [print-electronic]. 2010 Sep 9/7/2010; 55(17): 5151-68. PMID: 20714046, PMCID: PMC3808864, PII: S0031-9155(10)48338-4, DOI: 10.1088/0031-9155/55/17/017, ISSN: 1361-6560.

Tantawy MN, Peterson TE. Simplified [18F]FDG image-derived input function using the left ventricle, liver, and one venous blood sample. Mol Imaging. 2010 Apr; 9(2): 76-86. PMID: 20236605, PMCID: PMC4095848, ISSN: 1536-0121.

Tantawy MN, Jones CK, Baldwin RM, Ansari MS, Conn PJ, Kessler RM, Peterson TE. [(18)F]Fallypride dopamine D2 receptor studies using delayed microPET scans and a modified Logan plot. Nucl. Med. Biol [print-electronic]. 2009 Nov; 36(8): 931-40. PMID: 19875049, PMCID: PMC2771119, PII: S0969-8051(09)00155-3, DOI: 10.1016/j.nucmedbio.2009.06.007, ISSN: 1872-9614.

Peterson TE, Manning HC. Molecular imaging: 18F-FDG PET and a whole lot more. J Nucl Med Technol [print-electronic]. 2009 Sep; 37(3): 151-61. PMID: 19692452, PMCID: PMC2829876, PII: jnmt.109.062729, DOI: 10.2967/jnmt.109.062729, ISSN: 0091-4916.

Peterson TE, Shokouhi S, Furenlid LR, Wilson DW. Multi-pinhole SPECT Imaging with Silicon Strip Detectors. IEEE Trans Nucl Sci. 2009 Jun 6/16/2009; 56(3): 646-52. PMID: 20953300, PMCID: PMC2953820, DOI: 10.1109/TNS.2009.2012514, ISSN: 0018-9499.

Shokouhi S, McDonald BS, Durko HL, Fritz MA, Furenlid LR, Peterson TE. Thick Silicon Double-Sided Strip Detectors for Low-Energy Small-Animal SPECT. IEEE Trans Nucl Sci. 2009 Jun 6/1/2009; 56(3): 557-64. PMID: 20686626, PMCID: PMC2914306, DOI: 10.1109/TNS.2009.2019106, ISSN: 0018-9499.

Shokouhi S, Metzler SD, Wilson DW, Peterson TE. Multi-pinhole collimator design for small-object imaging with SiliSPECT: a high-resolution SPECT. Phys Med Biol [print-electronic]. 2009 Jan 1/21/2009; 54(2): 207-25. PMID: 19088387, PMCID: PMC2892935, PII: S0031-9155(09)90144-0, DOI: 10.1088/0031-9155/54/2/003, ISSN: 0031-9155.

Manning HC, Merchant NB, Foutch AC, Virostko JM, Wyatt SK, Shah C, McKinley ET, Xie J, Mutic NJ, Washington MK, LaFleur B, Tantawy MN, Peterson TE, Ansari MS, Baldwin RM, Rothenberg ML, Bornhop DJ, Gore JC, Coffey RJ. Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Clin. Cancer Res. 2008 Nov 11/15/2008; 14(22): 7413-22. PMID: 19010858, PMCID: PMC2657180, PII: 14/22/7413, DOI: 10.1158/1078-0432.CCR-08-0239, ISSN: 1078-0432.

Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J. Neurosci. 2008 Oct 10/8/2008; 28(41): 10422-33. PMID: 18842902, PMCID: PMC2577155, PII: 28/41/10422, DOI: 10.1523/JNEUROSCI.1850-08.2008, ISSN: 1529-2401.

Hariri G, Zhang Y, Fu A, Han Z, Brechbiel M, Tantawy MN, Peterson TE, Mernaugh R, Hallahan D. Radiation-guided P-selectin antibody targeted to lung cancer. Ann Biomed Eng [print-electronic]. 2008 May; 36(5): 821-30. PMID: 18273706, PMCID: PMC2292132, DOI: 10.1007/s10439-008-9444-9, ISSN: 1573-9686.

Li X, Yankeelov TE, Peterson TE, Gore JC, Dawant BM. Automatic nonrigid registration of whole body CT mice images. Med Phys. 2008 Apr; 35(4): 1507-20. PMID: 18491546, PMCID: PMC2673624, DOI: 10.1118/1.2889758, ISSN: 0094-2405.

Shokouhi S, Fritz MA, McDonald BS, Durko HL, Furenlid LR, Wilson DW, Peterson TE. A Silicon SPECT System for Molecular Imaging of the Mouse Brain. IEEE Nucl Sci Symp Conf Rec (1997). 2007 Oct; 2007: 2782-4. PMID: 26855557, PMCID: PMC4743882, DOI: 10.1109/NSSMIC.2007.4436717, ISSN: 1095-7863.

Shokouhi S, McDonald BS, Durko HL, Fritz MA, Furenlid LR, Peterson TE. Performance Characteristics of Thick Silicon Double-sided Strip Detectors. IEEE Nucl Sci Symp Conf Rec (1997). 2007 Oct; 2007: 1656-60. PMID: 26778911, PMCID: PMC4713046, DOI: 10.1109/NSSMIC.2007.4437318, ISSN: 1095-7863.

McDonald BS, Shokouhi S, Barrett HH, Peterson TE. Multi-energy, single-isotope imaging using stacked detectors. Nucl Instrum Methods Phys Res A. 2007 Aug 8/21/2007; 579(1): 196-9. PMID: 19081759, PMCID: PMC2600473, DOI: 10.1016/j.nima.2007.04.142, ISSN: 0168-9002.

Stabin MG, Peterson TE, Holburn GE, Emmons MA. Voxel-based mouse and rat models for internal dose calculations. J. Nucl. Med. 2006 Apr; 47(4): 655-9. PMID: 16595500, PII: 47/4/655, ISSN: 0161-5505.

Stathopoulos GT, Zhu Z, Everhart MB, Kalomenidis I, Lawson WE, Bilaceroglu S, Peterson TE, Mitchell D, Yull FE, Light RW, Blackwell TS. Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2006 Feb; 34(2): 142-50. PMID: 16210694, PMCID: PMC2644178, PII: 2005-0130OC, DOI: 10.1165/rcmb.2005-0130OC, ISSN: 1044-1549.

Kim H, Furenlid LR, Crawford MJ, Wilson DW, Barber HB, Peterson TE, Hunter WC, Liu Z, Woolfenden JM, Barrett HH. SemiSPECT: a small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays. Med Phys. 2006 Feb; 33(2): 465-74. PMID: 16532954, PMCID: PMC2655644, ISSN: 0094-2405.

Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer Cell. 2005 May; 7(5): 485-96. PMID: 15894268, PII: S1535-6108(05)00124-8, DOI: 10.1016/j.ccr.2005.04.013, ISSN: 1535-6108.

Sarsour M, Peterson T, Planinic M, Vigdor SE, Allgower C, Bergenwall B, Blomgren J, Hossbach T, Jacobs WW, Johansson C, Klug J, Klyachko AV, Nadel-Turonski P, Nilsson L, Olsson N, Pomp S, Rapaport J, Rinckel T, Stephenson EJ, Tippawan U, Wissink SW, Zhou Y. Measurement of the absolute n p scattering differential cross section at 194 MeV. Phys. Rev. Lett [print-electronic]. 2005 Mar 3/4/2005; 94(8): 82303. PMID: 15783880, DOI: 10.1103/PhysRevLett.94.082303, ISSN: 0031-9007.