Michael P. Stone, Ph.D.


Faculty Appointments
Professor of Chemistry Professor of Biochemistry
Ph.D., Physical Chemistry, University of California, Irvine, CaliforniaB.S., University of California, Davis, California
Office Address
VU Station B 351822
7332 Stevenson Center
Banerjee S, Christov PP, Kozekova A, Rizzo CJ, Egli M, Stone MP. Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV. Chem. Res. Toxicol [print-electronic]. 2012 Feb 2/20/2012; 25(2): 422-35. PMID: 22313351, PMCID: PMC3285121, DOI: 10.1021/tx200460j, ISSN: 1520-5010.

Huang H, Das RS, Basu AK, Stone MP. Structures of (5'S)-8,5'-Cyclo-2'-deoxyguanosine Mismatched with dA or dT. Chem. Res. Toxicol [print-electronic]. 2012 Feb 2/20/2012; 25(2): 478-90. PMID: 22309170, PMCID: PMC3285119, DOI: 10.1021/tx2005053, ISSN: 1520-5010.

Huang H, Das RS, Basu AK, Stone MP. Structure of (5'S)-8,5'-cyclo-2'-deoxyguanosine in DNA. J. Am. Chem. Soc [print-electronic]. 2011 Dec 12/21/2011; 133(50): 20357-68. PMID: 22103478, PMCID: PMC3279155, DOI: 10.1021/ja207407n, ISSN: 1520-5126.

Kowal EA, Ganguly M, Pallan PS, Marky LA, Gold B, Egli M, Stone MP. Altering the electrostatic potential in the major groove: thermodynamic and structural characterization of 7-deaza-2'-deoxyadenosine:dT base pairing in DNA. J Phys Chem B [print-electronic]. 2011 Dec 12/1/2011; 115(47): 13925-34. PMID: 22059929, PMCID: PMC3225014, DOI: 10.1021/jp207104w, ISSN: 1520-5207.

Huang H, Wang H, Kozekova A, Rizzo CJ, Stone MP. Formation of a N2-dG:N2-dG carbinolamine DNA cross-link by the trans-4-hydroxynonenal-derived (6S,8R,11S) 1,N2-dG adduct. J. Am. Chem. Soc [print-electronic]. 2011 Oct 10/12/2011; 133(40): 16101-10. PMID: 21916419, PMCID: PMC3187658, DOI: 10.1021/ja205145q, ISSN: 1520-5126.

Stone MP, Huang H, Brown KL, Shanmugam G. Chemistry and structural biology of DNA damage and biological consequences. Chem. Biodivers. 2011 Sep; 8(9): 1571-615. PMID: 21922653, PMCID: PMC3714022, DOI: 10.1002/cbdv.201100033, ISSN: 1612-1880.

Banerjee S, Brown KL, Egli M, Stone MP. Bypass of aflatoxin B1 adducts by the Sulfolobus solfataricus DNA polymerase IV. J. Am. Chem. Soc [print-electronic]. 2011 Aug 8/17/2011; 133(32): 12556-68. PMID: 21790157, PMCID: PMC3154525, DOI: 10.1021/ja2015668, ISSN: 1520-5126.

Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP. 1,N2-Etheno-2'-deoxyguanosine adopts the syn conformation about the glycosyl bond when mismatched with deoxyadenosine. Chem. Res. Toxicol [print-electronic]. 2011 Jul 7/18/2011; 24(7): 1071-9. PMID: 21675798, PMCID: PMC3138413, DOI: 10.1021/tx200089v, ISSN: 1520-5010.

Huang H, Wang H, Voehler MW, Kozekova A, Rizzo CJ, McCullough AK, Lloyd RS, Stone MP. ¿-Hydroxy-1,N2-propano-2'-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage. Chem. Res. Toxicol [print-electronic]. 2011 Jul 7/18/2011; 24(7): 1123-33. PMID: 21561113, PMCID: PMC3138414, DOI: 10.1021/tx200113n, ISSN: 1520-5010.

Christov PP, Petrova KV, Shanmugam G, Kozekov ID, Kozekova A, Guengerich FP, Stone MP, Rizzo CJ. Comparison of the in vitro replication of the 7-(2-oxoheptyl)-1,N2-etheno-2'-deoxyguanosine and 1,N2-etheno-2'-deoxyguanosine lesions by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). Chem. Res. Toxicol. 2010 Aug 8/16/2010; 23(8): 1330-41. PMID: 20578729, PMCID: PMC2922457, DOI: 10.1021/tx100082e, ISSN: 1520-5010.

Huang H, Kozekov ID, Kozekova A, Rizzo CJ, McCullough AK, Lloyd RS, Stone MP. Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1,N2-gamma-hydroxypropanodeoxyguanosine lesion with a trimethylene linkage. Biochemistry. 2010 Jul 7/27/2010; 49(29): 6155-64. PMID: 20604523, PMCID: PMC2907095, DOI: 10.1021/bi100364f, ISSN: 1520-4995.

Huang H, Kozekov ID, Kozekova A, Wang H, Lloyd RS, Rizzo CJ, Stone MP. DNA cross-link induced by trans-4-hydroxynonenal. Environ. Mol. Mutagen. 2010 Jul; 51(6): 625-34. PMID: 20577992, PMCID: PMC3140422, DOI: 10.1002/em.20599, ISSN: 1098-2280.

Christov PP, Chowdhury G, Garmendia CA, Wang F, Stover JS, Elmquist CE, Kozekova A, Angel KC, Turesky RJ, Stone MP, Guengerich FP, Rizzo CJ. The C8-2'-deoxyguanosine adduct of 2-amino-3-methylimidazo[1,2-d]naphthalene, a carbocyclic analogue of the potent mutagen 2-amino-3-methylimidazo[4,5-f]quinoline, is a block to replication in vitro. Chem. Res. Toxicol. 2010 Jun 6/21/2010; 23(6): 1076-88. PMID: 20377178, PMCID: PMC2891123, DOI: 10.1021/tx100053n, ISSN: 1520-5010.

Shanmugam G, Kozekov ID, Guengerich FP, Rizzo CJ, Stone MP. Structure of the 1,N(2)-etheno-2'-deoxyguanosine lesion in the 3'-G(epsilon dG)T-5' sequence opposite a one-base deletion. Biochemistry. 2010 Mar 3/30/2010; 49(12): 2615-26. PMID: 20201499, PMCID: PMC2844103, DOI: 10.1021/bi901516d, ISSN: 1520-4995.

Christov PP, Banerjee S, Stone MP, Rizzo CJ. Selective Incision of the alpha-N-Methyl-Formamidopyrimidine Anomer by Escherichia coli Endonuclease IV. J Nucleic Acids. 2010; 2010: PMID: 20798848, PMCID: PMC2925382, DOI: 10.4061/2010/850234, ISSN: 2090-021X.

Brown KL, Roginskaya M, Zou Y, Altamirano A, Basu AK, Stone MP. Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site. Nucleic Acids Res [print-electronic]. 2010 Jan; 38(2): 428-40. PMID: 19892827, PMCID: PMC2811006, PII: gkp844, DOI: 10.1093/nar/gkp844, ISSN: 1362-4962.

Brown KL, Voehler MW, Magee SM, Harris CM, Harris TM, Stone MP. Structural perturbations induced by the alpha-anomer of the aflatoxin B(1) formamidopyrimidine adduct in duplex and single-strand DNA. J. Am. Chem. Soc. 2009 Nov 11/11/2009; 131(44): 16096-107. PMID: 19831353, PMCID: PMC2773149, DOI: 10.1021/ja902052v, ISSN: 1520-5126.

Huang H, Dooley PA, Harris CM, Harris TM, Stone MP. Differential base stacking interactions induced by trimethylene interstrand DNA cross-links in the 5'-CpG-3' and 5'-GpC-3' sequence contexts. Chem. Res. Toxicol. 2009 Nov; 22(11): 1810-6. PMID: 19916525, PMCID: PMC2778138, DOI: 10.1021/tx900225c, ISSN: 1520-5010.

Brown KL, Basu AK, Stone MP. The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA. Biochemistry. 2009 Oct 10/20/2009; 48(41): 9722-33. PMID: 19772348, PMCID: PMC2761728, DOI: 10.1021/bi900695e, ISSN: 1520-4995.

Huang H, Kim HY, Kozekov ID, Cho YJ, Wang H, Kozekova A, Harris TM, Rizzo CJ, Stone MP. Stereospecific formation of the (R)-gamma-hydroxytrimethylene interstrand N2-dG:N2-dG cross-link arising from the gamma-OH-1,N2-propano-2'-deoxyguanosine adduct in the 5'-CpG-3' DNA sequence. J. Am. Chem. Soc. 2009 Jun 6/24/2009; 131(24): 8416-24. PMID: 19530727, PMCID: PMC2753404, DOI: 10.1021/ja809543j, ISSN: 1520-5126.