Gary Allen Sulikowski, Ph.D.

Faculty Appointments
Professor of Chemistry Stevenson Chair of ChemistryProfessor of Pharmacology
Ph.D., Chemistry, Organic, University of Pennsylvania, Philadelphia, PennsylvaniaB.S., Wayne State University, Detroit, Michigan
Office Address
12415F MRB IV
Research Description
Chemical synthesis of biologically active and architecturally interesting natural products, small molecule tool compounds for application in chemical biology and development of small molecule therapeutics. Natural product of current interest include arachidonic acid metabolites, antimicrobial natural products, and heterocyclic marine natural products.

Design, synthesis and evaluation of chemical probes probes to study ion channel biology (in collaboration with the Weaver lab, pharmacology).
Research Keywords
Stereocontrolled synthesis, total synthesis, chemical probes, heterocycle synthesis
Doroh B, Sulikowski GA. Progress toward the total synthesis of Bielschowskysin: a stereoselective [2+2] photocycloaddition. Org. Lett. 2006 Mar 3/2/2006; 8(5): 903-6. PMID: 16494470, PMCID: PMC2527052, DOI: 10.1021/ol0530225, ISSN: 1523-7060.

Kiewel K, Luo Z, Sulikowski GA. Stereocontrolled synthesis of the DE ring system of the marine alkaloid upenamide. Org. Lett. 2005 Nov 11/10/2005; 7(23): 5163-5. PMID: 16268528, DOI: 10.1021/ol051993e, ISSN: 1523-7060.

Lee WD, Kim K, Sulikowski GA. Studies into the stereoselectivity of tartrate-derived dienophiles. Org. Lett. 2005 Apr 4/28/2005; 7(9): 1687-9. PMID: 15844881, DOI: 10.1021/ol050105c, ISSN: 1523-7060.

Wu B, Liu Q, Sulikowski GA. Total synthesis of apoptolidinone. Angew. Chem. Int. Ed. Engl. 2004 Dec 12/10/2004; 43(48): 6673-5. PMID: 15593157, DOI: 10.1002/anie.200461469, ISSN: 1433-7851.

Boren B, Hirschi JS, Reibenspies JH, Tallant MD, Singleton DA, Sulikowski GA. Exo-selective Diels-Alder reactions of vinylazepines. Origin of divergent stereoselectivity in Diels-Alder reactions of vinylazepines, vinylpiperideines, and vinylcycloalkenes. J. Org. Chem. 2003 Nov 11/14/2003; 68(23): 8991-5. PMID: 14604372, DOI: 10.1021/jo034462h, ISSN: 0022-3263.

Kim K, Maharoof US, Raushel J, Sulikowski GA. Diverging stereochemical pathways in an intramolecular Diels-Alder reaction determined by dienophile structure. Org. Lett. 2003 Aug 8/7/2003; 5(16): 2777-80. PMID: 12889872, DOI: 10.1021/ol034823f, ISSN: 1523-7060.

Pennington JD, Williams HJ, Salomon AR, Sulikowski GA. Toward a stable apoptolidin derivative: identification of isoapoptolidin and selective deglycosylation of apoptolidin. Org. Lett. 2002 Oct 10/31/2002; 4(22): 3823-5. PMID: 12599468, ISSN: 1523-7060.

Sulikowski T, Bauer BA, Patston PA. Alpha(1)-Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1. Protein Sci. 2002 Sep; 11(9): 2230-6. PMID: 12192078, PMCID: PMC2373593, DOI: 10.1110/ps.0207302, ISSN: 0961-8368.

Sulikowski GA, Liu W, Agnelli F, Corbett RM, Luo Z, Hershberger SJ. Progress toward a biomimetic synthesis of phomoidride B. Org. Lett. 2002 May 5/2/2002; 4(9): 1451-4. PMID: 11975601, PII: ol025595c, ISSN: 1523-7060.

Sulikowski GA, Agnelli F, Spencer P, Koomen JM, Russell DH. Studies on the biosynthesis of phomoidride B (CP-263,114): evidence for a decarboxylative homodimerization pathway. Org. Lett. 2002 May 5/2/2002; 4(9): 1447-50. PMID: 11975600, PII: ol025594k, ISSN: 1523-7060.

Frantom PA, Pongdee R, Sulikowski GA, Fitzpatrick PF. Intrinsic deuterium isotope effects on benzylic hydroxylation by tyrosine hydroxylase. J. Am. Chem. Soc. 2002 Apr 4/24/2002; 124(16): 4202-3. PMID: 11960436, PII: ja025602s, ISSN: 0002-7863.

Pongdee R, Wu B, Sulikowski GA. One-pot synthesis of 2-deoxy-beta-oligosaccharides. Org. Lett. 2001 Nov 11/1/2001; 3(22): 3523-5. PMID: 11678698, PII: ol016593f, ISSN: 1523-7060.

Spencer P, Agnelli F, Sulikowski GA. Investigations into the production and interconversion of phomoidrides A-D. Org. Lett. 2001 May 5/17/2001; 3(10): 1443-5. PMID: 11388837, PII: ol015707k, ISSN: 1523-7060.

Sulikowski GA, Lee WM, Jin B, Wu B. Synthesis of the apoptosis inducing agent apoptolidin. Assembly of the C(16)-C(28) fragment. Org. Lett. 2000 May 5/18/2000; 2(10): 1439-42. PMID: 10814467, PII: ol005769v, ISSN: 1523-7060.

Sulikowski GA, Agnelli F, Corbett RM. Investigations into a biomimetic approach toward CP-225,917 and CP-263,114. J. Org. Chem. 2000 Jan 1/28/2000; 65(2): 337-42. PMID: 10813939, PII: jo9911286, ISSN: 0022-3263.

Crow RT, Rosenbaum B, Smith R, Guo Y, Ramos KS, Sulikowski GA. Landomycin A inhibits DNA synthesis and G1/S cell cycle progression. Bioorg. Med. Chem. Lett. 1999 Jun 6/21/1999; 9(12): 1663-6. PMID: 10397496, PII: S0960894X99002619, ISSN: 0960-894X.