David Harold Zald, Ph.D.



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Faculty Appointments
Director of Neuroscience Professor of Psychology Corenelius Vanderbilt ChairProfessor of Psychiatry and Behavioral Sciences
Ph.D., Clinical Psychology, University of Minnesota, Minneapolis, MinnesotaB.A., University of Michigan, Ann Arbor, Michigan
Office Address
325 Wilson Hall
Nashville, TN
Research Description
Dr. Zald uses functional neuroimaging and neuropsychological techniques to examine and map the cognitive, affective, and sensory functions of the orbitofrontal cortex, amygdala and related limbic regions. The long-term goal of this work is to determine how dysfunction of these areas contributes to psychiatric conditions such as obsessive-compulsive disorder. Related areas of interest include the neural substrates of object working memory, olfactory and gustatory processing, social judgment, and the biological underpinnings of anxiety
Research Keywords
Cognitive, affective and sensory functions of orbitofrontal cortex; OCD; fMRI.
Zald DH, Curtis C, Chernitsky LA, Pardo JV. Frontal lobe activation during object alternation acquisition. Neuropsychology. 2005 Jan; 19(1): 97-105. PMID: 15656767, PII: 2005-00128-011, DOI: 10.1037/0894-4105.19.1.97, ISSN: 0894-4105.

Zald DH, Boileau I, El-Dearedy W, Gunn R, McGlone F, Dichter GS, Dagher A. Dopamine transmission in the human striatum during monetary reward tasks. J. Neurosci. 2004 Apr 4/28/2004; 24(17): 4105-12. PMID: 15115805, PII: 24/17/4105, DOI: 10.1523/JNEUROSCI.4643-03.2004, ISSN: 1529-2401.

Zald DH. The human amygdala and the emotional evaluation of sensory stimuli. Brain Res. Brain Res. Rev. 2003 Jan; 41(1): 88-123. PMID: 12505650, PII: S0165017302002485.

Zald DH, Pardo JV. The neural correlates of aversive auditory stimulation. Neuroimage. 2002 Jul; 16(3 Pt 1): 746-53. PMID: 12169258, PII: S1053811902911158, ISSN: 1053-8119.

Zald DH, Curtis C, Folley BS, Pardo JV. Prefrontal contributions to delayed spatial and object alternation: a positron emission tomography study. Neuropsychology. 2002 Apr; 16(2): 182-9. PMID: 11949710, ISSN: 0894-4105.

Zald DH, Mattson DL, Pardo JV. Brain activity in ventromedial prefrontal cortex correlates with individual differences in negative affect. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2002 Feb 2/19/2002; 99(4): 2450-4. PMID: 11842195, PMCID: PMC122385, PII: 042457199, DOI: 10.1073/pnas.042457199, ISSN: 0027-8424.

Zald DH, Hagen MC, Pardo JV. Neural correlates of tasting concentrated quinine and sugar solutions. J. Neurophysiol. 2002 Feb; 87(2): 1068-75. PMID: 11826070, ISSN: 0022-3077.

Zald, D. H., & Kim, S. W. The orbitofrontal cortex. In S.P. Salloway, P. F. Malloy & J. D. Duffy (Eds.), The Frontal Lobes and Neuropsychiatric Illness. Washington, DC: American Psychiatric Press. 2001.