Jozef Zienkiewicz, Ph.D.

Research Associate Professor

jozef.zienkiewicz@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Medicine
Education
Ph.D., University of Wroclaw, Wroclaw, PolandM.S., University of Wroclaw, Wroclaw, Poland
Office Address
T-2220 MCN
1161 21st Ave. South
Nashville, TN 37232
Publications
Veach RA, Liu Y, Zienkiewicz J, Wylezinski LS, Boyd KL, Wynn JL, Hawiger J. Survival, bacterial clearance and thrombocytopenia are improved in polymicrobial sepsis by targeting nuclear transport shuttles. PLoS ONE. 2017 Jun 6/18/2017; 12(6): e0179468. PMID: 28628637, PII: PONE-D-17-04854, DOI: 10.1371/journal.pone.0179468, ISSN: 1932-6203.

Hawiger J, Veach RA, Zienkiewicz J. New paradigms in sepsis: from prevention to protection of failing microcirculation. J. Thromb. Haemost [print-electronic]. 2015 Oct; 13(10): 1743-56. PMID: 26190521, DOI: 10.1111/jth.13061, ISSN: 1538-7836.

DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J. The "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation. PLoS ONE. 2014 Oct 10/20/2014; 9(10): e110183. PMID: 25329889, PMCID: PMC4203769, PII: PONE-D-14-26863, DOI: 10.1371/journal.pone.0110183, ISSN: 1932-6203.

Zienkiewicz J, Armitage A, Hawiger J. Targeting nuclear import shuttles, importins/karyopherins alpha by a peptide mimicking the NFkB1/p50 nuclear localization sequence. J Am Heart Assoc. 2013 Oct; 2(5): e000386. PMID: 24042087, PMCID: PMC3835248, PII: jah3309, DOI: 10.1161/JAHA.113.000386, ISSN: 2047-9980.

Liu Y, Major AS, Zienkiewicz J, Gabriel CL, Veach RA, Moore DJ, Collins RD, Hawiger J. Nuclear transport modulation reduces hypercholesterolemia, atherosclerosis, and fatty liver. J Am Heart Assoc. 2013 Apr; 2(2): e000093. PMID: 23563994, PMCID: PMC3647260, PII: 2/2/e000093, DOI: 10.1161/JAHA.113.000093, ISSN: 2047-9980.

Shoemaker AH, Zienkiewicz J, Moore DJ. Clinical assessment of HNF1A and GCK variants and identification of a novel mutation causing MODY2. Diabetes Res. Clin. Pract [print-electronic]. 2012 May; 96(2): e36-9. PMID: 22341299, PMCID: PMC3560353, PII: S0168-8227(12)00058-7, DOI: 10.1016/j.diabres.2012.01.032, ISSN: 1872-8227.

Veach RA, Zienkiewicz J, Collins RD, Hawiger J. Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy. PLoS ONE. 2012 Jan 1/26/2012; 7(1): e30527. PMID: 22291977, PMCID: PMC3266913, PII: PONE-D-11-13071, DOI: 10.1371/journal.pone.0030527, ISSN: 1932-6203.

Moore DJ, Zienkiewicz J, Kendall PL, Liu D, Liu X, Veach RA, Collins RD, Hawiger J. In vivo islet protection by a nuclear import inhibitor in a mouse model of type 1 diabetes. PLoS ONE. 2010 Oct 10/5/2010; 5(10): e13235. PMID: 20949090, PMCID: PMC2950856, DOI: 10.1371/journal.pone.0013235, ISSN: 1932-6203.

Liu D, Zienkiewicz J, DiGiandomenico A, Hawiger J. Suppression of acute lung inflammation by intracellular peptide delivery of a nuclear import inhibitor. Mol. Ther [print-electronic]. 2009 May; 17(5): 796-802. PMID: 19259070, PMCID: PMC2835128, PII: mt200918, DOI: 10.1038/mt.2009.18, ISSN: 1525-0024.

Zienkiewicz J, Fryszkowska A, Zienkiewicz K, Guo F, Kaszynski P, Januszko A, Jones D. Synthesis of liquid crystalline 4H-benzo[1,2,4]thiadiazines and generation of persistent radicals. J. Org. Chem [print-electronic]. 2007 Apr 4/27/2007; 72(9): 3510-20. PMID: 17407358, DOI: 10.1021/jo070122a, ISSN: 0022-3263.

Li C, Zienkiewicz J, Hawiger J. Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway. J. Biol. Chem [print-electronic]. 2005 Jul 7/15/2005; 280(28): 26152-9. PMID: 15849357, PII: M503262200, DOI: 10.1074/jbc.M503262200, ISSN: 0021-9258.

Zienkiewicz J, Kaszynski P, Young VG. Experimental and theoretical studies of fused-ring persistent [1,2,4]thiadiazinyl radicals. J. Org. Chem. 2004 Oct 10/29/2004; 69(22): 7525-36. PMID: 15497978, DOI: 10.1021/jo0486746, ISSN: 0022-3263.

Zienkiewicz J, Kaszynski P, Young VG. Fused-ring thiadiazines: preparation and crystallographic characterization of 3-phenyl derivative of benzo-, pyridio[2,3-e]-, pyrazino[2,3-e]-, and tetrafluorobenzo-[1,2,4]thiadiazines. J. Org. Chem. 2004 Apr 4/2/2004; 69(7): 2551-61. PMID: 15049657, DOI: 10.1021/jo035835h, ISSN: 0022-3263.

Zienkiewicz J, Galewski Z. Liquid crystalline properties of 4-methyl-, 4-ethyl-and 4-propyl-4'-alkyloxyazobenzenes. Pol. J. Chem. 2002 Oct 10/10/2002; 73(2): 359-66.

Zienkiewicz J, Galewski Z. Liquid crystalline properties of 4-hexyl-4'-alkoxyazobenzenes and 4-heptyl-4'-alkoxyazobenzenes. Proc. SPIE. 1998 Jan 1/1/1998; 3319: 45-54.

Zienkiewicz J, Galewski Z. Smectic polymorphism of the 4-butyl-4'-alkoxyazobenzenes and 4-pentyl-4'-alkoxyazobenzenes. Liq. Cryst. 1997 Jul 7/1/1997; 23(1): 9-16. DOI: 10.1080/026782997208613.