Faculty Appointments
Professor of Biological Sciences
Professor of PharmacologyProfessor of PharmacologyCornelius Vanderbilt Chair in Biological SciencesCornelius Vanderbilt Chair in Biological Sciences
Education
Ph.D., Molecular Biology, Brandeis University, Waltham, MassachusettsM.S., Biology, University of Michigan, Ann Arbor, MichiganB.S., Biochemistry, Stony Brook University, Stony Brook, New York
Office Address
6260 Medical Research Building III
465 21st Ave. South
Nashville, KY 37235
465 21st Ave. South
Nashville, KY 37235
Research Description
The major focus of the laboratory is the characterization of specific genes and their products that control important behavioral processes in the life cycle of eusocial insects and mosquitoes that act as vectors for human disease.
One focus is on host (i.e. blood-meal source) seeking/selection in the mosquito Anopheles gambiae which is the principal vector for malaria in Africa. Malaria is caused by a protozoan parasite of the genus Plasmodium that is transmitted to humans through blood feeding by female Anopheline mosquitoes. In this context, we are examining the molecular events of olfaction as this sense predominates the overall host preference behaviors in mosquitoes and other insects. This aspect of the mosquito's behavior is especially important as it makes a significant contribution to the vectorial capacity of this arthropod vector, as well as playing a similar role in the overall impact of many other insects of economic importance.
The proteins that carry out olfactory signal transduction are present on the inside surface of the olfactory receptor neuron (ORN) dendritic membranes that in insects are located in hair like structures called sensilla. Signal transduction is initiated when odorants (either alone or in complexes with Odorant Binding Proteins) bind to members of seven transmembrane containing odorant receptors (ORs). Originally thought to be G-protein coupled, insect ORs are now almost universally recognized to be novel signaling complexes that combine ligand specificity subunit (conventional ORs) with a widely- expressed, non-conventional OR subunit that most probably acts as a direct ionotropic channel on ORN dendrites- in fruitflies this OR is known as 83b (in light of its position on polytene chromosomes) while in mosquitoes this common component is called OR7. Recent studies in Drosophila (Benton et. al. 2009) have also pointed to the existence of a novel class of chemosensory receptors known as ionotropic receptors (IRs) that have homology to insect glutamate receptors. Current efforts are focused on understanding how ORs, IRs, OBPs and other components of this pathway mediate olfactory signal transduction in anopheline mosquitoes.
We use molecular and informatics based approaches to identify genes that are active in olfactory signal transduction in An. gambiae and other disease vector mosquitoes. The molecular characterization of genes which mediate olfaction in this Anopheline mosquito has started with the generation of cDNA libraries specifically derived from olfactory (i.e. the antennal and maxillary palps) and neural (heads that have been stripped of antennal and maxillary palps) structures of female adult mosquitoes. These hand-dissected structures have been used as substrate for the synthesis of subtracted cDNA libraries using novel PCR based methods that are specifically designed to facilitate the use of picogram amounts of mRNA starting material. More recently we have focused on genomics based approaches that include genome mining and deep sequencing of olfactory transcriptomes that has thus resulted in the isolation of several olfactory genes from An. gambiae that are currently being characterized at the molecular and cellular levels.
Much of the lab's focus is on the molecular, biochemical and functional characterization of ORs An. gambiae (AgORs). Over the years "Team AgOR" has gone from the original characterization of AgORs insofar as their DNA sequence and organization to detailed in vivo expression studies. We have extended this study to include the use of ex vivo expression systems, electrophysiology, cell culture and transgenic insect systems (e.g.Drosophila) in order to study the functional characteristics of AgORs from specific senory appendages to whole genome wide approaches (see publication list).
A long-term objective of our work is the molecular characterization of the olfactory genes in general as well as the mechanisms that which are central in the marked
One focus is on host (i.e. blood-meal source) seeking/selection in the mosquito Anopheles gambiae which is the principal vector for malaria in Africa. Malaria is caused by a protozoan parasite of the genus Plasmodium that is transmitted to humans through blood feeding by female Anopheline mosquitoes. In this context, we are examining the molecular events of olfaction as this sense predominates the overall host preference behaviors in mosquitoes and other insects. This aspect of the mosquito's behavior is especially important as it makes a significant contribution to the vectorial capacity of this arthropod vector, as well as playing a similar role in the overall impact of many other insects of economic importance.
The proteins that carry out olfactory signal transduction are present on the inside surface of the olfactory receptor neuron (ORN) dendritic membranes that in insects are located in hair like structures called sensilla. Signal transduction is initiated when odorants (either alone or in complexes with Odorant Binding Proteins) bind to members of seven transmembrane containing odorant receptors (ORs). Originally thought to be G-protein coupled, insect ORs are now almost universally recognized to be novel signaling complexes that combine ligand specificity subunit (conventional ORs) with a widely- expressed, non-conventional OR subunit that most probably acts as a direct ionotropic channel on ORN dendrites- in fruitflies this OR is known as 83b (in light of its position on polytene chromosomes) while in mosquitoes this common component is called OR7. Recent studies in Drosophila (Benton et. al. 2009) have also pointed to the existence of a novel class of chemosensory receptors known as ionotropic receptors (IRs) that have homology to insect glutamate receptors. Current efforts are focused on understanding how ORs, IRs, OBPs and other components of this pathway mediate olfactory signal transduction in anopheline mosquitoes.
We use molecular and informatics based approaches to identify genes that are active in olfactory signal transduction in An. gambiae and other disease vector mosquitoes. The molecular characterization of genes which mediate olfaction in this Anopheline mosquito has started with the generation of cDNA libraries specifically derived from olfactory (i.e. the antennal and maxillary palps) and neural (heads that have been stripped of antennal and maxillary palps) structures of female adult mosquitoes. These hand-dissected structures have been used as substrate for the synthesis of subtracted cDNA libraries using novel PCR based methods that are specifically designed to facilitate the use of picogram amounts of mRNA starting material. More recently we have focused on genomics based approaches that include genome mining and deep sequencing of olfactory transcriptomes that has thus resulted in the isolation of several olfactory genes from An. gambiae that are currently being characterized at the molecular and cellular levels.
Much of the lab's focus is on the molecular, biochemical and functional characterization of ORs An. gambiae (AgORs). Over the years "Team AgOR" has gone from the original characterization of AgORs insofar as their DNA sequence and organization to detailed in vivo expression studies. We have extended this study to include the use of ex vivo expression systems, electrophysiology, cell culture and transgenic insect systems (e.g.Drosophila) in order to study the functional characteristics of AgORs from specific senory appendages to whole genome wide approaches (see publication list).
A long-term objective of our work is the molecular characterization of the olfactory genes in general as well as the mechanisms that which are central in the marked
Research Keywords
The comprehensive study of olfaction and olfactory-based behaviors in malaria and other disease vector mosquitoes
Publications
Ghaninia M, Berger SL, Reinberg D, Zwiebel LJ, Ray A, Liebig J. Antennal Olfactory Physiology and Behavior of Males of the Ponerine Ant Harpegnathos saltator. J. Chem. Ecol [print-electronic]. 2018 Nov; 44(11): 999-1007. PMID: 30191433, PII: 10.1007/s10886-018-1013-6, DOI: 10.1007/s10886-018-1013-6, ISSN: 1573-1561.
Saveer AM, Pitts RJ, Ferguson ST, Zwiebel LJ. Characterization of Chemosensory Responses on the Labellum of the Malaria Vector Mosquito, Anopheles coluzzii. Sci Rep. 2018 Apr 4/4/2018; 8(1): 5656. PMID: 29618749, PMCID: PMC5884837, PII: 10.1038/s41598-018-23987-y, DOI: 10.1038/s41598-018-23987-y, ISSN: 2045-2322.
Iovinella I, Caputo B, Calzetta M, Zwiebel LJ, Dani FR, Della Torre A. Profiles of soluble proteins in chemosensory organs of three members of the afro-tropical Anopheles gambiae complex. Comp. Biochem. Physiol. Part D Genomics Proteomics [print-electronic]. 2017 Dec; 24: 41-50. PMID: 28822866, PII: S1744-117X(17)30059-X, DOI: 10.1016/j.cbd.2017.07.005, ISSN: 1878-0407.
Lombardo F, Salvemini M, Fiorillo C, Nolan T, Zwiebel LJ, Ribeiro JM, Arcà B. Deciphering the olfactory repertoire of the tiger mosquito Aedes albopictus. BMC Genomics. 2017 Oct 10/11/2017; 18(1): 770. PMID: 29020917, PMCID: PMC5637092, PII: 10.1186/s12864-017-4144-1, DOI: 10.1186/s12864-017-4144-1, ISSN: 1471-2164.
Pask GM, Slone JD, Millar JG, Das P, Moreira JA, Zhou X, Bello J, Berger SL, Bonasio R, Desplan C, Reinberg D, Liebig J, Zwiebel LJ, Ray A. Specialized odorant receptors in social insects that detect cuticular hydrocarbon cues and candidate pheromones. Nat Commun. 2017 Aug 8/17/2017; 8(1): 297. PMID: 28819196, PMCID: PMC5561057, PII: 10.1038/s41467-017-00099-1, DOI: 10.1038/s41467-017-00099-1, ISSN: 2041-1723.
Yan H, Opachaloemphan C, Mancini G, Yang H, Gallitto M, Mlejnek J, Leibholz A, Haight K, Ghaninia M, Huo L, Perry M, Slone J, Zhou X, Traficante M, Penick CA, Dolezal K, Gokhale K, Stevens K, Fetter-Pruneda I, Bonasio R, Zwiebel LJ, Berger SL, Liebig J, Reinberg D, Desplan C. An Engineered orco Mutation Produces Aberrant Social Behavior and Defective Neural Development in Ants. Cell. 2017 Aug 8/10/2017; 170(4): 736-747.e9. PMID: 28802043, PMCID: PMC5587193, PII: S0092-8674(17)30770-5, DOI: 10.1016/j.cell.2017.06.051, ISSN: 1097-4172.
Slone JD, Pask GM, Ferguson ST, Millar JG, Berger SL, Reinberg D, Liebig J, Ray A, Zwiebel LJ. Functional characterization of odorant receptors in the ponerine ant, Harpegnathos saltator. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Aug 8/8/2017; 114(32): 8586-91. PMID: 28696298, PMCID: PMC5559025, PII: 1704647114, DOI: 10.1073/pnas.1704647114, ISSN: 1091-6490.
Ghaninia M, Haight K, Berger SL, Reinberg D, Zwiebel LJ, Ray A, Liebig J. Chemosensory sensitivity reflects reproductive status in the ant Harpegnathos saltator. Sci Rep. 2017 Jun 6/16/2017; 7(1): 3732. PMID: 28623371, PMCID: PMC5473913, PII: 10.1038/s41598-017-03964-7, DOI: 10.1038/s41598-017-03964-7, ISSN: 2045-2322.
Pitts RJ, Derryberry SL, Zhang Z, Zwiebel LJ. Variant Ionotropic Receptors in the Malaria Vector Mosquito Anopheles gambiae Tuned to Amines and Carboxylic Acids. Sci Rep. 2017 Jan 1/9/2017; 7: 40297. PMID: 28067294, PMCID: PMC5220300, PII: srep40297, DOI: 10.1038/srep40297, ISSN: 2045-2322.
Rinker DC, Pitts RJ, Zwiebel LJ. Disease vectors in the era of next generation sequencing. Genome Biol. 2016 May 5/6/2016; 17(1): 95. PMID: 27154554, PMCID: PMC4858832, PII: 10.1186/s13059-016-0966-4, DOI: 10.1186/s13059-016-0966-4, ISSN: 1474-760X.
Suh E, Choe DH, Saveer AM, Zwiebel LJ. Suboptimal Larval Habitats Modulate Oviposition of the Malaria Vector Mosquito Anopheles coluzzii. PLoS ONE. 2016; 11(2): e0149800. PMID: 26900947, PMCID: PMC4768836, DOI: 10.1371/journal.pone.0149800, ISSN: 1932-6203.
Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, Berger SL. Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus. Science. 2016 Jan 1/1/2016; 351(6268): aac6633. PMID: 26722000, PMCID: PMC5057185, DOI: 10.1126/science.aac6633, ISSN: 1095-9203.
Sharma KR, Enzmann BL, Schmidt Y, Moore D, Jones GR, Parker J, Berger SL, Reinberg D, Zwiebel LJ, Breit B, Liebig J, Ray A. Cuticular Hydrocarbon Pheromones for Social Behavior and Their Coding in the Ant Antenna. Cell Rep [print-electronic]. 2015 Aug 8/25/2015; 12(8): 1261-71. PMID: 26279569, PII: S2211-1247(15)00791-3, DOI: 10.1016/j.celrep.2015.07.031, ISSN: 2211-1247.
Zhou X, Rokas A, Berger SL, Liebig J, Ray A, Zwiebel LJ. Chemoreceptor Evolution in Hymenoptera and Its Implications for the Evolution of Eusociality [letter]. Genome Biol Evol. 2015 Aug; 7(8): 2407-16. PMID: 26272716, PMCID: PMC4558866, PII: evv149, DOI: 10.1093/gbe/evv149, ISSN: 1759-6653.
Neafsey DE, Waterhouse RM, Abai MR, Aganezov SS, Alekseyev MA, Allen JE, Amon J, Arcà B, Arensburger P, Artemov G, Assour LA, Basseri H, Berlin A, Birren BW, Blandin SA, Brockman AI, Burkot TR, Burt A, Chan CS, Chauve C, Chiu JC, Christensen M, Costantini C, Davidson VL, Deligianni E, Dottorini T, Dritsou V, Gabriel SB, Guelbeogo WM, Hall AB, Han MV, Hlaing T, Hughes DS, Jenkins AM, Jiang X, Jungreis I, Kakani EG, Kamali M, Kemppainen P, Kennedy RC, Kirmitzoglou IK, Koekemoer LL, Laban N, Langridge N, Lawniczak MK, Lirakis M, Lobo NF, Lowy E, MacCallum RM, Mao C, Maslen G, Mbogo C, McCarthy J, Michel K, Mitchell SN, Moore W, Murphy KA, Naumenko AN, Nolan T, Novoa EM, O'Loughlin S, Oringanje C, Oshaghi MA, Pakpour N, Papathanos PA, Peery AN, Povelones M, Prakash A, Price DP, Rajaraman A, Reimer LJ, Rinker DC, Rokas A, Russell TL, Sagnon N, Sharakhova MV, Shea T, Simão FA, Simard F, Slotman MA, Somboon P, Stegniy V, Struchiner CJ, Thomas GW, Tojo M, Topalis P, Tubio JM, Unger MF, Vontas J, Walton C, Wilding CS, Willis JH, Wu YC, Yan G, Zdobnov EM, Zhou X, Catteruccia F, Christophides GK, Collins FH, Cornman RS, Crisanti A, Donnelly MJ, Emrich SJ, Fontaine MC, Gelbart W, Hahn MW, Hansen IA, Howell PI, Kafatos FC, Kellis M, Lawson D, Louis C, Luckhart S, Muskavitch MA, Ribeiro JM, Riehle MA, Sharakhov IV, Tu Z, Zwiebel LJ, Besansky NJ. Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. Science [print-electronic]. 2015 Jan 1/2/2015; 347(6217): 1258522. PMID: 25554792, PMCID: PMC4380271, PII: science.1258522, DOI: 10.1126/science.1258522, ISSN: 1095-9203.
Suh E, Bohbot J, Zwiebel LJ. Peripheral olfactory signaling in insects. Curr Opin Insect Sci. 2014 Dec 12/1/2014; 6: 86-92. PMID: 25584200, PMCID: PMC4288021, DOI: 10.1016/j.cois.2014.10.006, ISSN: 2214-5745.
Turner RM, Derryberry SL, Kumar BN, Brittain T, Zwiebel LJ, Newcomb RD, Christie DL. Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from Drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation. J. Biol. Chem [print-electronic]. 2014 Nov 11/14/2014; 289(46): 31837-45. PMID: 25271160, PMCID: PMC4231661, PII: M114.603993, DOI: 10.1074/jbc.M114.603993, ISSN: 1083-351X.
Turner RM, Derryberry SL, Kumar BN, Brittain T, Zwiebel LJ, Newcomb RD, Christie DL. Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from Drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation. J. Biol. Chem [print-electronic]. 2014 Nov 11/14/2014; 289(46): 31837-45. PMID: 25271160, PMCID: PMC4231661, PII: M114.603993, DOI: 10.1074/jbc.M114.603993, ISSN: 1083-351X.
Hughes DT, Wang G, Zwiebel LJ, Luetje CW. A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit. Chem. Senses [print-electronic]. 2014 Nov; 39(9): 761-9. PMID: 25270378, PMCID: PMC4201304, PII: bju048, DOI: 10.1093/chemse/bju048, ISSN: 1464-3553.
Hughes DT, Wang G, Zwiebel LJ, Luetje CW. A determinant of odorant specificity is located at the extracellular loop 2-transmembrane domain 4 interface of an Anopheles gambiae odorant receptor subunit. Chem. Senses [print-electronic]. 2014 Nov; 39(9): 761-9. PMID: 25270378, PMCID: PMC4201304, PII: bju048, DOI: 10.1093/chemse/bju048, ISSN: 1464-3553.
Zhou X, Rinker DC, Pitts RJ, Rokas A, Zwiebel LJ. Divergent and conserved elements comprise the chemoreceptive repertoire of the nonblood-feeding mosquito Toxorhynchites amboinensis. Genome Biol Evol. 2014 Oct; 6(10): 2883-96. PMID: 25326137, PMCID: PMC4224357, PII: evu231, DOI: 10.1093/gbe/evu231, ISSN: 1759-6653.
Romaine IM, Taylor RW, Saidu SP, Kim K, Sulikowski GA, Zwiebel LJ, Waterson AG. Narrow SAR in odorant sensing Orco receptor agonists. Bioorg. Med. Chem. Lett [print-electronic]. 2014 Jun 6/15/2014; 24(12): 2613-6. PMID: 24813736, PMCID: PMC4111141, PII: S0960-894X(14)00438-7, DOI: 10.1016/j.bmcl.2014.04.081, ISSN: 1464-3405.
Romaine IM, Taylor RW, Saidu SP, Kim K, Sulikowski GA, Zwiebel LJ, Waterson AG. Narrow SAR in odorant sensing Orco receptor agonists. Bioorg. Med. Chem. Lett [print-electronic]. 2014 Jun 6/15/2014; 24(12): 2613-6. PMID: 24813736, PMCID: PMC4111141, PII: S0960-894X(14)00438-7, DOI: 10.1016/j.bmcl.2014.04.081, ISSN: 1464-3405.
Pitts RJ, Liu C, Zhou X, Malpartida JC, Zwiebel LJ. Odorant receptor-mediated sperm activation in disease vector mosquitoes. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Feb 2/18/2014; 111(7): 2566-71. PMID: 24550284, PMCID: PMC3932880, PII: 1322923111, DOI: 10.1073/pnas.1322923111, ISSN: 1091-6490.
Pitts RJ, Liu C, Zhou X, Malpartida JC, Zwiebel LJ. Odorant receptor-mediated sperm activation in disease vector mosquitoes. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Feb 2/18/2014; 111(7): 2566-71. PMID: 24550284, PMCID: PMC3932880, PII: 1322923111, DOI: 10.1073/pnas.1322923111, ISSN: 1091-6490.
Pitts RJ, Derryberry SL, Pulous FE, Zwiebel LJ. Antennal-expressed ammonium transporters in the malaria vector mosquito Anopheles gambiae. PLoS ONE. 2014; 9(10): e111858. PMID: 25360676, PMCID: PMC4216128, PII: PONE-D-14-20321, DOI: 10.1371/journal.pone.0111858, ISSN: 1932-6203.
Rinker DC, Pitts RJ, Zhou X, Suh E, Rokas A, Zwiebel LJ. Blood meal-induced changes to antennal transcriptome profiles reveal shifts in odor sensitivities in Anopheles gambiae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 May 5/14/2013; 110(20): 8260-5. PMID: 23630291, PMCID: PMC3657813, PII: 1302562110, DOI: 10.1073/pnas.1302562110, ISSN: 1091-6490.
Rinker DC, Pitts RJ, Zhou X, Suh E, Rokas A, Zwiebel LJ. Blood meal-induced changes to antennal transcriptome profiles reveal shifts in odor sensitivities in Anopheles gambiae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 May 5/14/2013; 110(20): 8260-5. PMID: 23630291, PMCID: PMC3657813, PII: 1302562110, DOI: 10.1073/pnas.1302562110, ISSN: 1091-6490.
Pask GM, Bobkov YV, Corey EA, Ache BW, Zwiebel LJ. Blockade of insect odorant receptor currents by amiloride derivatives. Chem. Senses [print-electronic]. 2013 Mar; 38(3): 221-9. PMID: 23292750, PMCID: PMC3569625, PII: bjs100, DOI: 10.1093/chemse/bjs100, ISSN: 1464-3553.
Pask GM, Romaine IM, Zwiebel LJ. The molecular receptive range of a lactone receptor in Anopheles gambiae. Chem. Senses [print-electronic]. 2013 Jan; 38(1): 19-25. PMID: 22944613, PMCID: PMC3522515, PII: bjs074, DOI: 10.1093/chemse/bjs074, ISSN: 1464-3553.
Rinker DC, Zhou X, Pitts RJ, , Rokas A, Zwiebel LJ. Antennal transcriptome profiles of anopheline mosquitoes reveal human host olfactory specialization in Anopheles gambiae. BMC Genomics. 2013; 14: 749. PMID: 24182346, PMCID: PMC3833343, PII: 1471-2164-14-749, DOI: 10.1186/1471-2164-14-749, ISSN: 1471-2164.
Liu C, Zwiebel LJ. Molecular characterization of larval peripheral thermosensory responses of the malaria vector mosquito Anopheles gambiae. PLoS ONE [electronic-print]. 2013; 8(8): e72595. PMID: 23940815, PMCID: PMC3737131, PII: PONE-D-13-23760, DOI: 10.1371/journal.pone.0072595, ISSN: 1932-6203.
Rinker DC, Zhou X, Pitts RJ, , Rokas A, Zwiebel LJ. Antennal transcriptome profiles of anopheline mosquitoes reveal human host olfactory specialization in Anopheles gambiae. BMC Genomics. 2013; 14: 749. PMID: 24182346, PMCID: PMC3833343, PII: 1471-2164-14-749, DOI: 10.1186/1471-2164-14-749, ISSN: 1471-2164.
Liu C, Zwiebel LJ. Molecular characterization of larval peripheral thermosensory responses of the malaria vector mosquito Anopheles gambiae. PLoS ONE [electronic-print]. 2013; 8(8): e72595. PMID: 23940815, PMCID: PMC3737131, PII: PONE-D-13-23760, DOI: 10.1371/journal.pone.0072595, ISSN: 1932-6203.
Taylor RW, Romaine IM, Liu C, Murthi P, Jones PL, Waterson AG, Sulikowski GA, Zwiebel LJ. Structure-activity relationship of a broad-spectrum insect odorant receptor agonist. ACS Chem. Biol [print-electronic]. 2012 Oct 10/19/2012; 7(10): 1647-52. PMID: 22924767, DOI: 10.1021/cb300331z, ISSN: 1554-8937.
Jones PL, Pask GM, Romaine IM, Taylor RW, Reid PR, Waterson AG, Sulikowski GA, Zwiebel LJ. Allosteric antagonism of insect odorant receptor ion channels. PLoS ONE [print-electronic]. 2012; 7(1): e30304. PMID: 22272331, PMCID: PMC3260273, PII: PONE-D-11-19400, DOI: 10.1371/journal.pone.0030304, ISSN: 1932-6203.
Zhou X, Slone JD, Rokas A, Berger SL, Liebig J, Ray A, Reinberg D, Zwiebel LJ. Phylogenetic and transcriptomic analysis of chemosensory receptors in a pair of divergent ant species reveals sex-specific signatures of odor coding. PLoS Genet [print-electronic]. 2012; 8(8): e1002930. PMID: 22952454, PMCID: PMC3431598, PII: PGENETICS-D-12-00741, DOI: 10.1371/journal.pgen.1002930, ISSN: 1553-7404.
Jones PL, Pask GM, Rinker DC, Zwiebel LJ. Functional agonism of insect odorant receptor ion channels. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 May 5/24/2011; 108(21): 8821-5. PMID: 21555561, PMCID: PMC3102409, PII: 1102425108, DOI: 10.1073/pnas.1102425108, ISSN: 1091-6490.
Pitts RJ, Rinker DC, Jones PL, Rokas A, Zwiebel LJ. Transcriptome profiling of chemosensory appendages in the malaria vector Anopheles gambiae reveals tissue- and sex-specific signatures of odor coding. BMC Genomics. 2011; 12: 271. PMID: 21619637, PMCID: PMC3126782, PII: 1471-2164-12-271, DOI: 10.1186/1471-2164-12-271, ISSN: 1471-2164.
Bohbot JD, Jones PL, Wang G, Pitts RJ, Pask GM, Zwiebel LJ. Conservation of indole responsive odorant receptors in mosquitoes reveals an ancient olfactory trait. Chem. Senses [print-electronic]. 2011 Jan; 36(2): 149-60. PMID: 20956733, PMCID: PMC3020388, PII: bjq105, DOI: 10.1093/chemse/bjq105, ISSN: 1464-3553.
Pask GM, Jones PL, Rützler M, Rinker DC, Zwiebel LJ. Heteromeric Anopheline odorant receptors exhibit distinct channel properties. PLoS ONE [print-electronic]. 2011; 6(12): e28774. PMID: 22174894, PMCID: PMC3235152, PII: PONE-D-11-18890, DOI: 10.1371/journal.pone.0028774, ISSN: 1932-6203.
Carey AF, Wang G, Su CY, Zwiebel LJ, Carlson JR. Odorant reception in the malaria mosquito Anopheles gambiae. Nature [print-electronic]. 2010 Mar 3/4/2010; 464(7285): 66-71. PMID: 20130575, PMCID: PMC2833235, PII: nature08834, DOI: 10.1038/nature08834, ISSN: 1476-4687.
Wang G, Carey AF, Carlson JR, Zwiebel LJ. Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Mar 3/2/2010; 107(9): 4418-23. PMID: 20160092, PMCID: PMC2840125, PII: 0913392107, DOI: 10.1073/pnas.0913392107, ISSN: 1091-6490.
Liu C, Pitts RJ, Bohbot JD, Jones PL, Wang G, Zwiebel LJ. Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. PLoS Biol. 2010; 8(8): PMID: 20824161, PMCID: PMC2930861, DOI: 10.1371/journal.pbio.1000467, ISSN: 1545-7885.
Wang G, Qiu YT, Lu T, Kwon HW, Pitts RJ, Van Loon JJ, Takken W, Zwiebel LJ. Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae. Eur. J. Neurosci [print-electronic]. 2009 Sep; 30(6): 967-74. PMID: 19735290, PMCID: PMC3106298, PII: EJN6901, DOI: 10.1111/j.1460-9568.2009.06901.x, ISSN: 1460-9568.
Xia Y, Wang G, Buscariollo D, Pitts RJ, Wenger H, Zwiebel LJ. The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Apr 4/29/2008; 105(17): 6433-8. PMID: 18427108, PMCID: PMC2359781, PII: 0801007105, DOI: 10.1073/pnas.0801007105, ISSN: 1091-6490.
Walker WB, Smith EM, Jan T, Zwiebel LJ. A functional role for Anopheles gambiae Arrestin1 in olfactory signal transduction. J. Insect Physiol [print-electronic]. 2008 Apr; 54(4): 680-90. PMID: 18328499, PMCID: PMC2408752, PII: S0022-1910(08)00022-X, DOI: 10.1016/j.jinsphys.2008.01.007, ISSN: 0022-1910.
Bohbot J, Pitts RJ, Kwon HW, Rützler M, Robertson HM, Zwiebel LJ. Molecular characterization of the Aedes aegypti odorant receptor gene family. Insect Mol. Biol [print-electronic]. 2007 Oct; 16(5): 525-37. PMID: 17635615, PMCID: PMC3100214, PII: IMB748, DOI: 10.1111/j.1365-2583.2007.00748.x, ISSN: 0962-1075.
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Pitts RJ, Liu C, Zhou X, Malpartida JC, Zwiebel LJ. Odorant receptor-mediated sperm activation in disease vector mosquitoes. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Feb 2/18/2014; 111(7): 2566-71. PMID: 24550284, PMCID: PMC3932880, PII: 1322923111, DOI: 10.1073/pnas.1322923111, ISSN: 1091-6490.
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Pitts RJ, Derryberry SL, Pulous FE, Zwiebel LJ. Antennal-expressed ammonium transporters in the malaria vector mosquito Anopheles gambiae. PLoS ONE. 2014; 9(10): e111858. PMID: 25360676, PMCID: PMC4216128, PII: PONE-D-14-20321, DOI: 10.1371/journal.pone.0111858, ISSN: 1932-6203.
Rinker DC, Pitts RJ, Zhou X, Suh E, Rokas A, Zwiebel LJ. Blood meal-induced changes to antennal transcriptome profiles reveal shifts in odor sensitivities in Anopheles gambiae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 May 5/14/2013; 110(20): 8260-5. PMID: 23630291, PMCID: PMC3657813, PII: 1302562110, DOI: 10.1073/pnas.1302562110, ISSN: 1091-6490.
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Taylor RW, Romaine IM, Liu C, Murthi P, Jones PL, Waterson AG, Sulikowski GA, Zwiebel LJ. Structure-activity relationship of a broad-spectrum insect odorant receptor agonist. ACS Chem. Biol [print-electronic]. 2012 Oct 10/19/2012; 7(10): 1647-52. PMID: 22924767, DOI: 10.1021/cb300331z, ISSN: 1554-8937.
Jones PL, Pask GM, Romaine IM, Taylor RW, Reid PR, Waterson AG, Sulikowski GA, Zwiebel LJ. Allosteric antagonism of insect odorant receptor ion channels. PLoS ONE [print-electronic]. 2012; 7(1): e30304. PMID: 22272331, PMCID: PMC3260273, PII: PONE-D-11-19400, DOI: 10.1371/journal.pone.0030304, ISSN: 1932-6203.
Zhou X, Slone JD, Rokas A, Berger SL, Liebig J, Ray A, Reinberg D, Zwiebel LJ. Phylogenetic and transcriptomic analysis of chemosensory receptors in a pair of divergent ant species reveals sex-specific signatures of odor coding. PLoS Genet [print-electronic]. 2012; 8(8): e1002930. PMID: 22952454, PMCID: PMC3431598, PII: PGENETICS-D-12-00741, DOI: 10.1371/journal.pgen.1002930, ISSN: 1553-7404.
Jones PL, Pask GM, Rinker DC, Zwiebel LJ. Functional agonism of insect odorant receptor ion channels. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 May 5/24/2011; 108(21): 8821-5. PMID: 21555561, PMCID: PMC3102409, PII: 1102425108, DOI: 10.1073/pnas.1102425108, ISSN: 1091-6490.
Pitts RJ, Rinker DC, Jones PL, Rokas A, Zwiebel LJ. Transcriptome profiling of chemosensory appendages in the malaria vector Anopheles gambiae reveals tissue- and sex-specific signatures of odor coding. BMC Genomics. 2011; 12: 271. PMID: 21619637, PMCID: PMC3126782, PII: 1471-2164-12-271, DOI: 10.1186/1471-2164-12-271, ISSN: 1471-2164.
Bohbot JD, Jones PL, Wang G, Pitts RJ, Pask GM, Zwiebel LJ. Conservation of indole responsive odorant receptors in mosquitoes reveals an ancient olfactory trait. Chem. Senses [print-electronic]. 2011 Jan; 36(2): 149-60. PMID: 20956733, PMCID: PMC3020388, PII: bjq105, DOI: 10.1093/chemse/bjq105, ISSN: 1464-3553.
Pask GM, Jones PL, Rützler M, Rinker DC, Zwiebel LJ. Heteromeric Anopheline odorant receptors exhibit distinct channel properties. PLoS ONE [print-electronic]. 2011; 6(12): e28774. PMID: 22174894, PMCID: PMC3235152, PII: PONE-D-11-18890, DOI: 10.1371/journal.pone.0028774, ISSN: 1932-6203.
Carey AF, Wang G, Su CY, Zwiebel LJ, Carlson JR. Odorant reception in the malaria mosquito Anopheles gambiae. Nature [print-electronic]. 2010 Mar 3/4/2010; 464(7285): 66-71. PMID: 20130575, PMCID: PMC2833235, PII: nature08834, DOI: 10.1038/nature08834, ISSN: 1476-4687.
Wang G, Carey AF, Carlson JR, Zwiebel LJ. Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Mar 3/2/2010; 107(9): 4418-23. PMID: 20160092, PMCID: PMC2840125, PII: 0913392107, DOI: 10.1073/pnas.0913392107, ISSN: 1091-6490.
Liu C, Pitts RJ, Bohbot JD, Jones PL, Wang G, Zwiebel LJ. Distinct olfactory signaling mechanisms in the malaria vector mosquito Anopheles gambiae. PLoS Biol. 2010; 8(8): PMID: 20824161, PMCID: PMC2930861, DOI: 10.1371/journal.pbio.1000467, ISSN: 1545-7885.
Wang G, Qiu YT, Lu T, Kwon HW, Pitts RJ, Van Loon JJ, Takken W, Zwiebel LJ. Anopheles gambiae TRPA1 is a heat-activated channel expressed in thermosensitive sensilla of female antennae. Eur. J. Neurosci [print-electronic]. 2009 Sep; 30(6): 967-74. PMID: 19735290, PMCID: PMC3106298, PII: EJN6901, DOI: 10.1111/j.1460-9568.2009.06901.x, ISSN: 1460-9568.
Xia Y, Wang G, Buscariollo D, Pitts RJ, Wenger H, Zwiebel LJ. The molecular and cellular basis of olfactory-driven behavior in Anopheles gambiae larvae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Apr 4/29/2008; 105(17): 6433-8. PMID: 18427108, PMCID: PMC2359781, PII: 0801007105, DOI: 10.1073/pnas.0801007105, ISSN: 1091-6490.
Walker WB, Smith EM, Jan T, Zwiebel LJ. A functional role for Anopheles gambiae Arrestin1 in olfactory signal transduction. J. Insect Physiol [print-electronic]. 2008 Apr; 54(4): 680-90. PMID: 18328499, PMCID: PMC2408752, PII: S0022-1910(08)00022-X, DOI: 10.1016/j.jinsphys.2008.01.007, ISSN: 0022-1910.
Bohbot J, Pitts RJ, Kwon HW, Rützler M, Robertson HM, Zwiebel LJ. Molecular characterization of the Aedes aegypti odorant receptor gene family. Insect Mol. Biol [print-electronic]. 2007 Oct; 16(5): 525-37. PMID: 17635615, PMCID: PMC3100214, PII: IMB748, DOI: 10.1111/j.1365-2583.2007.00748.x, ISSN: 0962-1075.
Lu T, Qiu YT, Wang G, Kwon JY, Rutzler M, Kwon HW, Pitts RJ, van Loon JJ, Takken W, Carlson JR, Zwiebel LJ. Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae. Curr. Biol [print-electronic]. 2007 Sep 9/18/2007; 17(18): 1533-44. PMID: 17764944, PMCID: PMC3113458, PII: S0960-9822(07)01780-0, DOI: 10.1016/j.cub.2007.07.062, ISSN: 0960-9822.
Rützler M, Lu T, Zwiebel LJ. Galpha encoding gene family of the malaria vector mosquito Anopheles gambiae: expression analysis and immunolocalization of AGalphaq and AGalphao in female antennae. J. Comp. Neurol. 2006 Dec 12/1/2006; 499(4): 533-45. PMID: 17029251, PMCID: PMC3113460, DOI: 10.1002/cne.21083, ISSN: 0021-9967.
Kwon HW, Lu T, Rützler M, Zwiebel LJ. Olfactory responses in a gustatory organ of the malaria vector mosquito Anopheles gambiae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Sep 9/5/2006; 103(36): 13526-31. PMID: 16938890, PMCID: PMC1569196, PII: 0601107103, DOI: 10.1073/pnas.0601107103, ISSN: 0027-8424.
Xia Y, Zwiebel LJ. Identification and characterization of an odorant receptor from the West Nile virus mosquito, Culex quinquefasciatus. Insect Biochem. Mol. Biol [print-electronic]. 2006 Mar; 36(3): 169-76. PMID: 16503478, PMCID: PMC3100213, PII: S0965-1748(05)00225-0, DOI: 10.1016/j.ibmb.2005.12.003, ISSN: 0965-1748.
Pitts RJ, Zwiebel LJ. Antennal sensilla of two female anopheline sibling species with differing host ranges. Malar. J. 2006; 5: 26. PMID: 16573828, PMCID: PMC1532926, PII: 1475-2875-5-26, DOI: 10.1186/1475-2875-5-26, ISSN: 1475-2875.
Rützler M, Zwiebel LJ. Molecular biology of insect olfaction: recent progress and conceptual models. J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol [print-electronic]. 2005 Sep; 191(9): 777-90. PMID: 16094545, DOI: 10.1007/s00359-005-0044-y, ISSN: 0340-7594.
Merrill CE, Sherertz TM, Walker WB, Zwiebel LJ. Odorant-specific requirements for arrestin function in Drosophila olfaction. J. Neurobiol. 2005 Apr; 63(1): 15-28. PMID: 15627264, DOI: 10.1002/neu.20113, ISSN: 0022-3034.
Zwiebel LJ, Takken W. Olfactory regulation of mosquito-host interactions. Insect Biochem. Mol. Biol. 2004 Jul; 34(7): 645-52. PMID: 15242705, PMCID: PMC3100215, PII: S0965174804000682, DOI: 10.1016/j.ibmb.2004.03.017, ISSN: 0965-1748.
Melo AC, Rützler M, Pitts RJ, Zwiebel LJ. Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs. Chem. Senses. 2004 Jun; 29(5): 403-10. PMID: 15201207, PII: 29/5/403, DOI: 10.1093/chemse/bjh041, ISSN: 0379-864X.
Pitts RJ, Fox AN, Zwiebel LJ. A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Apr 4/6/2004; 101(14): 5058-63. PMID: 15037749, PMCID: PMC387373, PII: 0308146101, DOI: 10.1073/pnas.0308146101, ISSN: 0027-8424.
Hallem EA, Nicole Fox A, Zwiebel LJ, Carlson JR. Olfaction: mosquito receptor for human-sweat odorant. Nature. 2004 Jan 1/15/2004; 427(6971): 212-3. PMID: 14724626, PII: 427212a, DOI: 10.1038/427212a, ISSN: 1476-4687.
Merrill CE, Pitts RJ, Zwiebel LJ. Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae. Insect Mol. Biol. 2003 Dec; 12(6): 641-50. PMID: 14986925, ISSN: 0962-1075.
Xu PX, Zwiebel LJ, Smith DP. Identification of a distinct family of genes encoding atypical odorant-binding proteins in the malaria vector mosquito, Anopheles gambiae. Insect Mol. Biol. 2003 Dec; 12(6): 549-60. PMID: 14986916, ISSN: 0962-1075.
Hill CA, Fox AN, Pitts RJ, Kent LB, Tan PL, Chrystal MA, Cravchik A, Collins FH, Robertson HM, Zwiebel LJ. G protein-coupled receptors in Anopheles gambiae. Science. 2002 Oct 10/4/2002; 298(5591): 176-8. PMID: 12364795, PII: 298/5591/176, DOI: 10.1126/science.1076196, ISSN: 1095-9203.
Fox AN, Pitts RJ, Zwiebel LJ. A cluster of candidate odorant receptors from the malaria vector mosquito, Anopheles gambiae. Chem. Senses. 2002 Jun; 27(5): 453-9. PMID: 12052782, ISSN: 0379-864X.
Merrill CE, Riesgo-Escovar J, Pitts RJ, Kafatos FC, Carlson JR, Zwiebel LJ. Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2002 Feb 2/5/2002; 99(3): 1633-8. PMID: 11792843, PMCID: PMC122242, PII: 022505499, DOI: 10.1073/pnas.022505499, ISSN: 0027-8424.
Fox AN, Pitts RJ, Robertson HM, Carlson JR, Zwiebel LJ. Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Dec 12/4/2001; 98(25): 14693-7. PMID: 11724964, PMCID: PMC64743, PII: 261432998, DOI: 10.1073/pnas.261432998, ISSN: 0027-8424.
Pitts RJ, Zwiebel LJ. Isolation and characterization of the Xanthine dehydrogenase gene of the Mediterranean fruit fly, Ceratitis capitata. Genetics. 2001 Aug; 158(4): 1645-55. PMID: 11514452, PMCID: PMC1461762, ISSN: 0016-6731.
Gomulski LM, Pitts RJ, Costa S, Saccone G, Torti C, Polito LC, Gasperi G, Malacrida AR, Kafatos FC, Zwiebel LJ. Genomic organization and characterization of the white locus of the Mediterranean fruitfly, Ceratitis capitata. Genetics. 2001 Mar; 157(3): 1245-55. PMID: 11238408, PMCID: PMC1461546, ISSN: 0016-6731.
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Available Postdoctoral Position Details
Posted: 10/3/2014
Vector Chemosensory Neurobiology & Behavior Post-Doctoral Position Available at Vanderbilt University. An NIH-funded post-doctoral position is available in the Departments of Biological Sciences and Pharmacology at Vanderbilt University. We study mosquito olfaction and its role in modulating and mosquito-host interactions from an molecular neuroscience perspective using diverse approaches and methodologies. We are focused on the role of odorant receptors and other molecular elements of the peripheral sensory apparatus in driving host and oviposition preferences in both Anopheles gambiae and Aedes aegypti. We are looking for a highly motivated, independently-thinking individual, who wants to design and conduct laboratory studies on the peripheral sensory system of disease vectors. A Ph.D. in molecular neuroscience, entomology, behavior, molecular genetics, or related field and at least one first-author publication are required. Experience in chemosensory biology, molecular biology, behavior, and statistical analysis is desirable. No more than 5 years since completion of Ph.D. degree. To apply, please send CV, statement of research interests, reprints of recent papers, and names of three references to LJ Zwiebel (E-mail: l.zwiebel@vanderbilt.edu ) by August 15, 2010.
Additional information can be found in: http://www.cas.vanderbilt.edu/zwiebel/
Vector Chemosensory Neurobiology & Behavior Post-Doctoral Position Available at Vanderbilt University. An NIH-funded post-doctoral position is available in the Departments of Biological Sciences and Pharmacology at Vanderbilt University. We study mosquito olfaction and its role in modulating and mosquito-host interactions from an molecular neuroscience perspective using diverse approaches and methodologies. We are focused on the role of odorant receptors and other molecular elements of the peripheral sensory apparatus in driving host and oviposition preferences in both Anopheles gambiae and Aedes aegypti. We are looking for a highly motivated, independently-thinking individual, who wants to design and conduct laboratory studies on the peripheral sensory system of disease vectors. A Ph.D. in molecular neuroscience, entomology, behavior, molecular genetics, or related field and at least one first-author publication are required. Experience in chemosensory biology, molecular biology, behavior, and statistical analysis is desirable. No more than 5 years since completion of Ph.D. degree. To apply, please send CV, statement of research interests, reprints of recent papers, and names of three references to LJ Zwiebel (E-mail: l.zwiebel@vanderbilt.edu ) by August 15, 2010.
Additional information can be found in: http://www.cas.vanderbilt.edu/zwiebel/