Jeffrey N. Johnston, Ph.D.

Faculty Appointments
Professor of Chemistry Stevenson Professor of Chemistry
Ph.D., synthetic organic chemistry, Ohio State University, Columbus, OhioB.S., Xavier University, Cincinnati, Ohio
Research Description
Organic synthesis: development of new chemical reactions, reagents, and methods; total synthesis of complex natural products, peptides, and chiral small molecule therapeutics; enantioselective catalysis
Research Keywords
synthesis, catalysis, therapeutic development
Batiste SM, Blackwell DJ, Kim K, Kryshtal DO, Gomez-Hurtado N, Rebbeck RT, Cornea RL, Johnston JN, Knollmann BC. Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2019 Mar 3/12/2019; 116(11): 4810-5. PMID: 30792355, PMCID: PMC6421472, PII: 1816685116, DOI: 10.1073/pnas.1816685116, ISSN: 1091-6490.

Vishe M, Johnston JN. The inverted ketene synthon: a double umpolung approach to enantioselective ß2,3-amino amide synthesis. Chem Sci. 2019 Jan 1/28/2019; 10(4): 1138-43. PMID: 30774911, PMCID: PMC6349014, PII: c8sc04330b, DOI: 10.1039/c8sc04330b, ISSN: 2041-6520.

Yousefi R, Struble TJ, Payne JL, Vishe M, Schley ND, Johnston JN. Catalytic, Enantioselective Synthesis of Cyclic Carbamates from Dialkyl Amines by CO2-Capture: Discovery, Development, and Mechanism. J. Am. Chem. Soc. 2019 Jan; 141: 618-25. PMID: 30582326, DOI: 10.1021/jacs.8b11793, ISSN: 1520-5126.

Kearney SE, Zahoránszky-Kohalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci [print-electronic]. 2018 Dec 12/26/2018; 4(12): 1727-41. PMID: 30648156, PMCID: PMC6311695, DOI: 10.1021/acscentsci.8b00747, ISSN: 2374-7943.

Struble TJ, Lankswert HM, Pink M, Johnston JN. Enantioselective Organocatalytic Amine-Isocyanate Capture-Cyclization: Regioselective Alkene Iodoamination for the Synthesis of Chiral Cyclic Ureas. ACS Catal [print-electronic]. 2018 Dec 12/7/2018; 8(12): 11926-31. PMID: 31131150, PMCID: PMC6528665, DOI: 10.1021/acscatal.8b03708, ISSN: 2155-5435.

Tsukanov SV, Johnson MD, May SA, Kolis SP, Yates MH, Johnston JN. Continuous Platform to Generate Nitroalkanes On-Demand (in situ) using Peracetic Acid-Mediated Oxidation in a PFA Pipes-in-Series Reactor. Org Process Res Dev [print-electronic]. 2018 Aug 8/17/2018; 22(8): 971-7. PMID: 30906182, PMCID: PMC6424520, DOI: 10.1021/acs.oprd.8b00113, ISSN: 1083-6160.

Batiste SM, Johnston JN. Evidence for Ion-Templation During Macrocyclooligomerization of Depsipeptides. J. Am. Chem. Soc [print-electronic]. 2018 Apr 4/4/2018; 140(13): 4560-8. PMID: 29565576, DOI: 10.1021/jacs.7b13148, ISSN: 1520-5126.

Sprague DJ, Singh A, Johnston JN. Diastereo- and enantioselective additions of a-nitro esters to imines for anti-a,ß-diamino acid synthesis with a-alkyl-substitution. Chem Sci. 2018 Feb 2/28/2018; 9(8): 2336-9. PMID: 29719706, PMCID: PMC5903423, PII: c7sc05176j, DOI: 10.1039/c7sc05176j, ISSN: 2041-6520.

Knowe MT, Danneman MW, Sun S, Pink M, Johnston JN. Biomimetic Desymmetrization of a Carboxylic Acid. J. Am. Chem. Soc [print-electronic]. 2018 Feb 2/14/2018; 140(6): 1998-2001. PMID: 29400455, PMCID: PMC5814305, DOI: 10.1021/jacs.7b12185, ISSN: 1520-5126.

Vilgelm AE, Cobb P, Malikayil K, Flaherty D, Andrew Johnson C, Raman D, Saleh N, Higgins B, Vara BA, Johnston JN, Johnson DB, Kelley MC, Chen SC, Ayers GD, Richmond A. MDM2 Antagonists Counteract Drug-Induced DNA Damage. EBioMedicine [print-electronic]. 2017 Oct; 24: 43-55. PMID: 29030058, PMCID: PMC5652019, PII: S2352-3964(17)30369-9, DOI: 10.1016/j.ebiom.2017.09.016, ISSN: 2352-3964.

Tokumaru K, Bera K, Johnston JN. 1,3,4-Oxadiazole and Heteroaromatic-Fused 1,2,4-Triazole Synthesis using Diverted Umpolung Amide Synthesis. Synthesis (Stuttg) [print-electronic]. 2017 Oct; 49(20): 4670-5. PMID: 29507449, PMCID: PMC5833303, DOI: 10.1055/s-0036-1590802, ISSN: 0039-7881.

Tokumaru K, Johnston JN. A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions. Chem Sci [print-electronic]. 2017 Apr 4/1/2017; 8(4): 3187-91. PMID: 28507694, PMCID: PMC5414388, PII: c7sc00195a, DOI: 10.1039/c7sc00195a, ISSN: 2041-6520.

Batiste SM, Johnston JN. Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2016 Dec 12/27/2016; 113(52): 14893-7. PMID: 27974608, PII: 1616462114, DOI: 10.1073/pnas.1616462114, ISSN: 1091-6490.

Schwieter KE, Johnston JN. On-Demand Complex Peptide Synthesis: An Aspirational (and Elusive?) Goal for Peptide Synthesis. J. Am. Chem. Soc [print-electronic]. 2016 Nov 11/2/2016; 138(43): 14160-9. PMID: 27740747, DOI: 10.1021/jacs.6b08663, ISSN: 1520-5126.

Vara BA, Johnston JN. Enantioselective Synthesis of ß-Fluoro Amines via ß-Amino a-Fluoro Nitroalkanes and a Traceless Activating Group Strategy. J. Am. Chem. Soc [print-electronic]. 2016 Oct 10/17/2016; PMID: 27749040, DOI: 10.1021/jacs.6b07731, ISSN: 1520-5126.

Tsukanov SV, Johnson MD, May SA, Rosemeyer M, Watkins MA, Kolis SP, Yates MH, Johnston JN. Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle. Org Process Res Dev [print-electronic]. 2016 Feb 2/19/2016; 20(2): 215-26. PMID: 27065720, PMCID: PMC4821467, DOI: 10.1021/acs.oprd.5b00245, ISSN: 1083-6160.

Lim VT, Tsukanov SV, Stephens AB, Johnston JN. Enantioselective Synthesis of a-Bromonitroalkanes for Umpolung Amide Synthesis: Preparation of tert-Butyl ((1R)-1-(4-(benzyloxy)phenyl)-2-bromo-2-nitroethyl)carbamate. Organic Synth. 2016; 93: 88-99. PMID: 28579652, PMCID: PMC5453646, DOI: 10.15227/orgsyn.093.0088, ISSN: 0078-6209.

Schwieter KE, Johnston JN. A one-pot amidation of primary nitroalkanes. Chem. Commun. (Camb.). 2015 Dec 12/15/2015; 52(1): 152-5. PMID: 26506056, DOI: 10.1039/c5cc08415f, ISSN: 1364-548X.

Danneman MW, Hong KB, Johnston JN. A Unified Approach to the Four Azaindoline Families by Inter-/Intramolecular Annulative Diamination of Vinylpyridines. Org. Lett [print-electronic]. 2015 Aug 8/7/2015; 17(15): 3806-9. PMID: 26186041, DOI: 10.1021/acs.orglett.5b01783, ISSN: 1523-7052.

Vara BA, Struble TJ, Wang W, Dobish MC, Johnston JN. Enantioselective small molecule synthesis by carbon dioxide fixation using a dual Brønsted acid/base organocatalyst. J. Am. Chem. Soc [print-electronic]. 2015 Jun 6/17/2015; 137(23): 7302-5. PMID: 26039818, PMCID: PMC4708058, DOI: 10.1021/jacs.5b04425, ISSN: 1520-5126.

Danneman MW, Hong KB, Johnston JN. Oxidative inter-/intermolecular alkene diamination of hydroxy styrenes with electron-rich amines. Org. Lett [print-electronic]. 2015 May 5/15/2015; 17(10): 2558-61. PMID: 25942322, DOI: 10.1021/acs.orglett.5b01177, ISSN: 1523-7052.

Sprague DJ, Nugent BM, Yoder RA, Vara BA, Johnston JN. Adaptation of a small-molecule hydrogen-bond donor catalyst to an enantioselective hetero-Diels-Alder reaction hypothesized for brevianamide biosynthesis. Org. Lett [print-electronic]. 2015 Feb 2/20/2015; 17(4): 880-3. PMID: 25697748, PMCID: PMC4339957, DOI: 10.1021/ol503626w, ISSN: 1523-7052.

Schwieter KE, Johnston JN. Enantioselective Synthesis of D-a-Amino Amides from Aliphatic Aldehydes. Chem Sci. 2015; 6(4): 2590-5. PMID: 25838883, PMCID: PMC4378585, DOI: 10.1039/C5SC00064E, ISSN: 2041-6520.

Vilgelm AE, Pawlikowski JS, Liu Y, Hawkins OE, Davis TA, Smith J, Weller KP, Horton LW, McClain CM, Ayers GD, Turner DC, Essaka DC, Stewart CF, Sosman JA, Kelley MC, Ecsedy JA, Johnston JN, Richmond A. Mdm2 and aurora kinase a inhibitors synergize to block melanoma growth by driving apoptosis and immune clearance of tumor cells. Cancer Res [print-electronic]. 2015 Jan 1/1/2015; 75(1): 181-93. PMID: 25398437, PMCID: PMC4286469, PII: 0008-5472.CAN-14-2405, DOI: 10.1158/0008-5472.CAN-14-2405, ISSN: 1538-7445.

Toda Y, Pink M, Johnston JN. Brønsted acid catalyzed phosphoramidic acid additions to alkenes: diastereo- and enantioselective halogenative cyclizations for the synthesis of C- and P-chiral phosphoramidates. J. Am. Chem. Soc [print-electronic]. 2014 Oct 10/22/2014; 136(42): 14734-7. PMID: 25336273, PMCID: PMC4210055, DOI: 10.1021/ja5088584, ISSN: 1520-5126.

Schwieter KE, Shen B, Shackleford JP, Leighty MW, Johnston JN. Umpolung amide synthesis using substoichiometric N-iodosuccinimide (NIS) and oxygen as a terminal oxidant. Org. Lett [print-electronic]. 2014 Sep 9/19/2014; 16(18): 4714-7. PMID: 25198239, PMCID: PMC4168777, DOI: 10.1021/ol502089v, ISSN: 1523-7052.

Vara BA, Mayasundari A, Tellis JC, Danneman MW, Arredondo V, Davis TA, Min J, Finch K, Guy RK, Johnston JN. Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition. J. Org. Chem [print-electronic]. 2014 Aug 8/1/2014; 79(15): 6913-38. PMID: 25017623, PMCID: PMC4120989, DOI: 10.1021/jo501003r, ISSN: 1520-6904.

Hong KB, Johnston JN. Alkene diamination using electron-rich amines: hypervalent iodine-promoted inter-/intramolecular C-N bond formation. Org. Lett [print-electronic]. 2014 Jul 7/18/2014; 16(14): 3804-7. PMID: 24981419, DOI: 10.1021/ol501693j, ISSN: 1523-7052.

Makley DM, Johnston JN. Silyl imine electrophiles in enantioselective catalysis: a Rosetta Stone for peptide homologation, enabling diverse N-protected aryl glycines from aldehydes in three steps. Org. Lett [print-electronic]. 2014 Jun 6/6/2014; 16(11): 3146-9. PMID: 24828455, PMCID: PMC4059254, DOI: 10.1021/ol501297a, ISSN: 1523-7052.

Davis TA, Vilgelm AE, Richmond A, Johnston JN. Preparation of (-)-Nutlin-3 using enantioselective organocatalysis at decagram scale. J. Org. Chem [print-electronic]. 2013 Nov 11/1/2013; 78(21): 10605-16. PMID: 24127627, PMCID: PMC3880828, DOI: 10.1021/jo401321a, ISSN: 1520-6904.

Villalta F, Dobish MC, Nde PN, Kleshchenko YY, Hargrove TY, Johnson CA, Waterman MR, Johnston JN, Lepesheva GI. VNI cures acute and chronic experimental Chagas disease. J. Infect. Dis [print-electronic]. 2013 Aug 8/1/2013; 208(3): 504-11. PMID: 23372180, PMCID: PMC3698996, PII: jit042, DOI: 10.1093/infdis/jit042, ISSN: 1537-6613.

Pigza JA, Han JS, Chandra A, Mutnick D, Pink M, Johnston JN. Total synthesis of the Lycopodium alkaloid serratezomine A using free radical-mediated vinyl amination to prepare a ß-stannyl enamine linchpin. J. Org. Chem [print-electronic]. 2013 Feb 2/1/2013; 78(3): 822-43. PMID: 23273261, PMCID: PMC3565160, DOI: 10.1021/jo302333s, ISSN: 1520-6904.

Dobish MC, Villalta F, Waterman MR, Lepesheva GI, Johnston JN. Organocatalytic, enantioselective synthesis of VNI: a robust therapeutic development platform for Chagas, a neglected tropical disease. Org. Lett [print-electronic]. 2012 Dec 12/21/2012; 14(24): 6322-5. PMID: 23214987, PMCID: PMC3528807, DOI: 10.1021/ol303092v, ISSN: 1523-7052.

Leighty MW, Shen B, Johnston JN. Enantioselective synthesis of a-oxy amides via Umpolung amide synthesis. J. Am. Chem. Soc [print-electronic]. 2012 Sep 9/19/2012; 134(37): 15233-6. PMID: 22967461, PMCID: PMC3477818, DOI: 10.1021/ja306225u, ISSN: 1520-5126.

Davis TA, Danneman MW, Johnston JN. Chiral proton catalysis of secondary nitroalkane additions to azomethine: synthesis of a potent GlyT1 inhibitor. Chem. Commun. (Camb.) [print-electronic]. 2012 Jun 6/7/2012; 48(45): 5578-80. PMID: 22543734, PMCID: PMC4133115, DOI: 10.1039/c2cc32225k, ISSN: 1364-548X.

Dobish MC, Johnston JN. Achiral counterion control of enantioselectivity in a Brønsted acid-catalyzed iodolactonization. J. Am. Chem. Soc [print-electronic]. 2012 Apr 4/11/2012; 134(14): 6068-71. PMID: 22463391, PMCID: PMC3326820, DOI: 10.1021/ja301858r, ISSN: 1520-5126.

Shackleford JP, Shen B, Johnston JN. Discovery of competing anaerobic and aerobic pathways in umpolung amide synthesis allows for site-selective amide 18O-labeling. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 Jan 1/3/2012; 109(1): 44-6. PMID: 22184227, PMCID: PMC3252937, PII: 1113553108, DOI: 10.1073/pnas.1113553108, ISSN: 1091-6490.

Davis TA, Dobish MC, Schwieter KE, Chun AC, Johnston JN. Preparation of H,(4) PyrrolidineQuin-BAM (PBAM). Organic Synth [print-electronic]. 2012; 89: 380-93. PMID: 23180898, PMCID: PMC3505069, ISSN: 0078-6209.

Chandra A, Johnston JN. Total synthesis of the chlorine-containing hapalindoles K, A, and G. Angew. Chem. Int. Ed. Engl [print-electronic]. 2011 Aug 8/8/2011; 50(33): 7641-4. PMID: 21739540, PMCID: PMC3357111, DOI: 10.1002/anie.201100957, ISSN: 1521-3773.

Troyer TL, Muchalski H, Hong KB, Johnston JN. Origins of selectivity in Brønsted acid-promoted diazoalkane-azomethine reactions (the aza-Darzens aziridine synthesis). Org. Lett [print-electronic]. 2011 Apr 4/1/2011; 13(7): 1790-2. PMID: 21366339, DOI: 10.1021/ol200313m, ISSN: 1523-7052.

Johnston JN. A chiral N-phosphinyl phosphoramide: another offspring for the sage phosphoric acid progenitor. Angew. Chem. Int. Ed. Engl [print-electronic]. 2011 Mar 3/21/2011; 50(13): 2890-1. PMID: 21328512, PMCID: PMC3415224, DOI: 10.1002/anie.201006951, ISSN: 1521-3773.

Tomasiak TM, Archuleta TL, Andréll J, Luna-Chávez C, Davis TA, Sarwar M, Ham AJ, McDonald WH, Yankovskaya V, Stern HA, Johnston JN, Maklashina E, Cecchini G, Iverson TM. Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase. J. Biol. Chem [print-electronic]. 2011 Jan 1/28/2011; 286(4): 3047-56. PMID: 21098488, PMCID: PMC3024798, PII: M110.192849, DOI: 10.1074/jbc.M110.192849, ISSN: 1083-351X.

Davis TA, Johnston JN. Catalytic, Enantioselective Synthesis of Stilbene cis-Diamines: A Concise Preparation of (-)-Nutlin-3, a Potent p53/MDM2 Inhibitor. Chem Sci [print-electronic]. 2011 Jan 1/1/2011; 2(6): 1076-9. PMID: 22708054, PMCID: PMC3375951, DOI: 10.1039/C1SC00061F, ISSN: 2041-6520.

Muchalski H, Doody AB, Troyer TL, Johnston JN. PREPARATION OF ISOPROPYL 2-DIAZOACETYL(PHENYL)CARBAMATE. Organic Synth [print-electronic]. 2011; 88: 212-23. PMID: 23180897, PMCID: PMC3505074, ISSN: 0078-6209.

Dobish MC, Johnston JN. Chiral Brønsted base-promoted nitroalkane alkylation: enantioselective synthesis of sec-alkyl-3-substituted indoles. Org. Lett [print-electronic]. 2010 Dec 12/17/2010; 12(24): 5744-7. PMID: 21090654, PMCID: PMC3005818, DOI: 10.1021/ol1025712, ISSN: 1523-7052.

Shen B, Makley DM, Johnston JN. Umpolung reactivity in amide and peptide synthesis. Nature. 2010 Jun 6/24/2010; 465(7301): 1027-32. PMID: 20577205, PMCID: PMC2945247, PII: nature09125, DOI: 10.1038/nature09125, ISSN: 1476-4687.

Johnston JN, Muchalski H, Troyer TL. To protonate or alkylate? Stereoselective Brønsted acid catalysis of C-C bond formation using diazoalkanes. Angew. Chem. Int. Ed. Engl. 2010 Mar 3/22/2010; 49(13): 2290-8. PMID: 20209537, DOI: 10.1002/anie.200904828, ISSN: 1521-3773.

Davis TA, Wilt JC, Johnston JN. Bifunctional asymmetric catalysis: amplification of Brønsted basicity can orthogonally increase the reactivity of a chiral Brønsted acid. J. Am. Chem. Soc. 2010 Mar 3/10/2010; 132(9): 2880-2. PMID: 20151644, PMCID: PMC2838452, DOI: 10.1021/ja908814h, ISSN: 1520-5126.

Muchalski H, Hong KB, Johnston JN. Brønsted acid-promoted azide-olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A. Beilstein J Org Chem. 2010; 6: 1206-10. PMID: 21283562, PMCID: PMC3028999, DOI: 10.3762/bjoc.6.138, ISSN: 1860-5397.

Troyer TL, Muchalski H, Johnston JN. Brønsted acid activation of alpha-diazo imide: a syn-selective glycolate Mannich reaction. Chem. Commun. (Camb.) [print-electronic]. 2009 Nov 11/7/2009; (41): 6195-7. PMID: 19826666, DOI: 10.1039/b913785h, ISSN: 1364-548X.

Donahue MG, Hong KB, Johnston JN. Use of comparative triazolinium triflate fragmentation rates as a tool to assay relative competency of Brønsted bases in N-->N proton transfer. Bioorg. Med. Chem. Lett [print-electronic]. 2009 Sep 9/1/2009; 19(17): 4971-3. PMID: 19640710, PII: S0960-894X(09)01032-4, DOI: 10.1016/j.bmcl.2009.07.067, ISSN: 1464-3405.

Chandra A, Pigza JA, Han JS, Mutnick D, Johnston JN. Total synthesis of the lycopodium alkaloid (+)-serratezomine A. J. Am. Chem. Soc. 2009 Mar 3/18/2009; 131(10): 3470-1. PMID: 19236097, PMCID: PMC2677822, DOI: 10.1021/ja900536d, ISSN: 1520-5126.

Shen B, Johnston JN. A formal enantioselective acetate Mannich reaction: the nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of beta-amino acids. Org. Lett [print-electronic]. 2008 Oct 10/16/2008; 10(20): 4397-400. PMID: 18798639, DOI: 10.1021/ol801797h, ISSN: 1523-7052.

Wilt JC, Pink M, Johnston JN. A diastereo- and enantioselective synthesis of alpha-substituted anti-alpha,beta-diaminophosphonic acid derivatives. Chem. Commun. (Camb.) [print-electronic]. 2008 Sep 9/21/2008; (35): 4177-9. PMID: 18802521, DOI: 10.1039/b808393b, ISSN: 1359-7345.

Luesse SB, Counceller CM, Wilt JC, Perkins BR, Johnston JN. A Preparation of enantiomerically enriched axially chiral beta-diketimines: synthesis of (-)- and (+)-IAN amine. Org. Lett [print-electronic]. 2008 Jun 6/19/2008; 10(12): 2445-7. PMID: 18476708, DOI: 10.1021/ol800728b, ISSN: 1523-7060.

Singh A, Johnston JN. A diastereo- and enantioselective synthesis of alpha-substituted syn-alpha,beta-diamino acids. J. Am. Chem. Soc [print-electronic]. 2008 May 5/7/2008; 130(18): 5866-7. PMID: 18410096, DOI: 10.1021/ja8011808, ISSN: 1520-5126.

Viswanathan R, Smith CR, Prabhakaran EN, Johnston JN. Free radical-mediated aryl amination: convergent two- and three-component couplings to chiral 2,3-disubstituted indolines. J. Org. Chem [print-electronic]. 2008 Apr 4/18/2008; 73(8): 3040-6. PMID: 18351776, DOI: 10.1021/jo702523u, ISSN: 0022-3263.

Hong KB, Donahue MG, Johnston JN. On the nature of rate acceleration in the synthesis and fragmentation of triazolines by Brønsted acid: secondary catalysis by water (hydronium triflate). J. Am. Chem. Soc [print-electronic]. 2008 Feb 2/20/2008; 130(7): 2323-8. PMID: 18217758, DOI: 10.1021/ja0779452, ISSN: 1520-5126.

Chandra A, Viswanathan R, Johnston JN. Synthesis of the ABC- and D-ring systems of the indole alkaloid ambiguine G. Org. Lett [print-electronic]. 2007 Nov 11/22/2007; 9(24): 5027-9. PMID: 17975918, PMCID: PMC2617716, DOI: 10.1021/ol702247a, ISSN: 1523-7060.

Singh A, Yoder RA, Shen B, Johnston JN. Chiral proton catalysis: enantioselective Brønsted acid catalyzed additions of nitroacetic acid derivatives as glycine equivalents. J. Am. Chem. Soc [print-electronic]. 2007 Mar 3/28/2007; 129(12): 3466-7. PMID: 17341075, DOI: 10.1021/ja068073r, ISSN: 0002-7863.

Williams AL, Srinivasan JM, Johnston JN. Synthesis of an advanced intermediate en route to the mitomycin natural products. Org. Lett. 2006 Dec 12/21/2006; 8(26): 6047-9. PMID: 17165926, PMCID: PMC2533355, DOI: 10.1021/ol0624676, ISSN: 1523-7060.

Donahue MG, Johnston JN. Preparation of a protected phosphoramidon precursor via an H-phosphonate coupling strategy. Bioorg. Med. Chem. Lett [print-electronic]. 2006 Nov 11/1/2006; 16(21): 5602-4. PMID: 16935501, PII: S0960-894X(06)00913-9, DOI: 10.1016/j.bmcl.2006.08.024, ISSN: 0960-894X.

Yoder RA, Johnston JN. A case study in biomimetic total synthesis: polyolefin carbocyclizations to terpenes and steroids. Chem. Rev. 2005 Dec; 105(12): 4730-56. PMID: 16351060, PMCID: PMC2575671, DOI: 10.1021/cr040623l, ISSN: 0009-2665.

Mahoney JM, Smith CR, Johnston JN. Bronsted acid-promoted olefin aziridination and formal anti-aminohydroxylation. J. Am. Chem. Soc. 2005 Feb 2/9/2005; 127(5): 1354-5. PMID: 15686350, DOI: 10.1021/ja045608c, ISSN: 0002-7863.

Nugent BM, Yoder RA, Johnston JN. Chiral proton catalysis: a catalytic enantioselective direct aza-Henry reaction. J. Am. Chem. Soc. 2004 Mar 3/24/2004; 126(11): 3418-9. PMID: 15025457, DOI: 10.1021/ja031906i, ISSN: 0002-7863.

Williams AL, Johnston JN. The Brønsted acid-catalyzed direct aza-Darzens synthesis of N-alkyl cis-aziridines. J. Am. Chem. Soc. 2004 Feb 2/18/2004; 126(6): 1612-3. PMID: 14871074, DOI: 10.1021/ja0385282, ISSN: 0002-7863.

Viswanathan R, Mutnick D, Johnston JN. The first azacyclopentenyl carbinyl radical isomerizations (ACCRI): independent use of steric and electronic (polarization) effects as gating elements. J. Am. Chem. Soc. 2003 Jun 6/18/2003; 125(24): 7266-71. PMID: 12797800, DOI: 10.1021/ja029426z, ISSN: 0002-7863.

Viswanathan R, Prabhakaran EN, Plotkin MA, Johnston JN. Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis. J. Am. Chem. Soc. 2003 Jan 1/8/2003; 125(1): 163-8. PMID: 12515518, DOI: 10.1021/ja0284308, ISSN: 0002-7863.

Prabhakaran EN, Nugent BM, Williams AL, Nailor KE, Johnston JN. Free radical-mediated vinyl amination: access to N,N-dialkyl enamines and their beta-stannyl and beta-thio derivatives. Org. Lett. 2002 Nov 11/28/2002; 4(24): 4197-200. PMID: 12443057, PII: ol027064u, DOI: 10.1021/ol027064u, ISSN: 1523-7060.

Cortright SB, Johnston JN. IAN-amines: direct entry to a chiral C(2)-symmetric zirconium(IV) beta-diketimine complex. Angew. Chem. Int. Ed. Engl. 2002 Jan 1/18/2002; 41(2): 345-8. PMID: 12491428, PII: 10.1002/1521-3773(20020118)41:2<345::AID-ANIE345>3.0.CO;2-U, ISSN: 1433-7851.

Cox AL, Johnston JN. Use of the vicinal element effect for regiochemical control of quinone substitutions and its implication for convergent mitomycin construction. Org. Lett. 2001 Nov 11/15/2001; 3(23): 3695-7. PMID: 11700115, PII: ol016625z, ISSN: 1523-7060.

Evans DA, Scheidt KA, Johnston JN, Willis MC. Enantioselective and diastereoselective Mukaiyama-Michael reactions catalyzed by bis(oxazoline) copper(II) complexes. J. Am. Chem. Soc. 2001 May 5/16/2001; 123(19): 4480-91. PMID: 11457234, PII: ja010302g, ISSN: 0002-7863.

Johnston JN, Plotkin MA, Viswanathan R, Prabhakaran EN. Nonconventional carbon additions to azomethines. aryl amination/indoline synthesis by direct aryl radical addition to azomethine nitrogen. Org. Lett. 2001 Apr 4/5/2001; 3(7): 1009-11. PMID: 11277782, PII: ol007065r, ISSN: 1523-7060.

King SD, Wynter SH, Bain BC, Brown WA, Johnston JN, Delk AS. Comparison of testing saliva and serum for detection of antibody to human immunodeficiency virus in Jamaica, West Indies. J. Clin. Virol. 2000 Dec; 19(3): 157-61. PMID: 11090751, PII: S1386653200001438, ISSN: 1386-6532.

Evans DA, Willis MC, Johnston JN. Catalytic enantioselective Michael additions to unsaturated ester derivatives using chiral copper(II) Lewis acid complexes. Org. Lett. 1999 Sep 9/23/1999; 1(6): 865-8. PMID: 10823215, ISSN: 1523-7060.

Johnston JN, Tsui HC, Paquette LA. Application of an S --> O Allylic Transposition in the Context of a Bridgehead Olefinic System. New Opportunities for the Structural Modification of Bicyclo[6.2.1]undecanes via Transannular Ring Closure. J. Org. Chem. 1998 Jan 1/9/1998; 63(1): 129-36. PMID: 11674053, PII: jo971591n, ISSN: 1520-6904.