John A. McLean, Ph.D.

Faculty Appointments
Professor of Chemistry Stevenson Professor of Chemistry
Ph.D., Chemistry, George Washington University, Washington, District of ColumbiaM.Phil., Analytical Chemistry, George Washington University, Washington, District of ColumbiaB.S., Chemistry, University of Michigan, Ann Arbor, Michigan
Research Description
Our research focuses on the design, construction, and application of advanced technologies for structural mass spectrometry, in particular, for studies in structural proteomics, systems biology, and biophysics. To identify and structurally characterize biomolecules from complex samples, we perform rapid (µs-ms) two-dimensional gas-phase separations using ion mobility-mass spectrometry (IM-MS) techniques. IM-MS provides separations on the basis of apparent surface area (ion-neutral collision cross section) and mass-to-charge (m/z), respectively. Biomolecular structural information is interpreted by comparing experimentally obtained collision cross-sections in the context of those obtained via molecular dynamics simulations.
Research Keywords
Bioanalytical and Biophysical Chemistry