Zhaohua Ding, Ph.D.

Research Associate Professor


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Faculty Appointments
Research Associate Professor of Electrical Engineering Research Associate Professor of Biomedical Engineering
Ph.D., Biomedical Engineering, Ohio State University, Columbus, OhioM.S., Computer & Information Science, Ohio State University, Columbus, OhioB.E., University of Electronic Science and Technology, Chengdu, China
Office Address
1161 21st Avenue South
AA-1105 MCN
Nashville, TN 37232-2310
Research Description
My research interest is development of advanced imaging and computational methods for brain research. Specifically I have been developing MRI based techniques for mapping functional structure in the complex neural networks of the human brain. Current focuses include understanding fundamental structure-function relations in certain neural circuits, establishing mathematical models that characterize the dynamics of such relations, and developing advanced MRI techniques for imaging brain functional structure with high spatial and temporal resolutions and conspicuity.
Research Keywords
Imaging functional structure of the human brain
Ding Z, Xu R, Bailey SK, Wu TL, Morgan VL, Cutting LE, Anderson AW, Gore JC. Visualizing functional pathways in the human brain using correlation tensors and magnetic resonance imaging. Magn Reson Imaging [print-electronic]. 2016 Jan; 34(1): 8-17. PMID: 26477562, PMCID: PMC4714593, PII: S0730-725X(15)00225-8, DOI: 10.1016/j.mri.2015.10.003, ISSN: 1873-5894.

Ou X, Andres A, Pivik RT, Cleves MA, Snow JH, Ding Z, Badger TM. Voxel-Based Morphometry and fMRI Revealed Differences in Brain Gray Matter in Breastfed and Milk Formula-Fed Children. AJNR Am J Neuroradiol [print-electronic]. 2015 Nov 11/19/2015; PMID: 26585259, PII: ajnr.A4593, DOI: 10.3174/ajnr.A4593, ISSN: 1936-959X.

Buck AK, Ding Z, Elder CP, Towse TF, Damon BM. Anisotropic Smoothing Improves DT-MRI-Based Muscle Fiber Tractography. PLoS ONE. 2015; 10(5): e0126953. PMID: 26010830, PMCID: PMC4444336, PII: PONE-D-14-28260, DOI: 10.1371/journal.pone.0126953, ISSN: 1932-6203.

Shokouhi S, Rogers BP, Kang H, Ding Z, Claassen DO, Mckay JW, Riddle WR, . Modeling clustered activity increase in amyloid-beta positron emission tomographic images with statistical descriptors. Clin Interv Aging. 2015; 10: 759-70. PMID: 25945042, PMCID: PMC4408970, PII: cia-10-759, DOI: 10.2147/CIA.S82128, ISSN: 1178-1998.

Ou X, Andres A, Cleves MA, Pivik RT, Snow JH, Ding Z, Badger TM. Sex-specific association between infant diet and white matter integrity in 8-y-old children. Pediatr. Res [print-electronic]. 2014 Dec; 76(6): 535-43. PMID: 25167204, PII: pr2014129, DOI: 10.1038/pr.2014.129, ISSN: 1530-0447.

Ou X, Glasier CM, Ramakrishnaiah RH, Mulkey SB, Ding Z, Angtuaco TL, Andres A, Kaiser JR. Impaired white matter development in extremely low-birth-weight infants with previous brain hemorrhage. AJNR Am J Neuroradiol [print-electronic]. 2014 Oct; 35(10): 1983-9. PMID: 24874534, PMCID: PMC4207210, PII: ajnr.A3988, DOI: 10.3174/ajnr.A3988, ISSN: 1936-959X.

Gao Y, Khare SP, Panda S, Choe AS, Stepniewska I, Li X, Ding Z, Anderson A, Landman BA. A brain MRI atlas of the common squirrel monkey, Saimiri sciureus. Proc SPIE Int Soc Opt Eng. 2014 Mar 3/13/2014; 9038: 90380C. PMID: 24817811, PMCID: PMC4013108, DOI: 10.1117/12.2043589, ISSN: 0277-786X.

Wu X, Liu S, Wu M, Sun H, Zhou J, Gong Q, Ding Z. Nonlocal denoising using anisotropic structure tensor for 3D MRI. Med Phys. 2013 Oct; 40(10): 101904. PMID: 24089906, DOI: 10.1118/1.4820370, ISSN: 0094-2405.

Shokouhi S, Claassen D, Kang H, Ding Z, Rogers B, Mishra A, Riddle WR, . Longitudinal progression of cognitive decline correlates with changes in the spatial pattern of brain 18F-FDG PET. J. Nucl. Med [print-electronic]. 2013 Sep; 54(9): 1564-9. PMID: 23864720, PMCID: PMC4134885, PII: jnumed.112.116137, DOI: 10.2967/jnumed.112.116137, ISSN: 1535-5667.

Xu Q, Anderson AW, Gore JC, Ding Z. Gray matter parcellation constrained full brain fiber bundling with diffusion tensor imaging. Med Phys. 2013 Jul; 40(7): 72301. PMID: 23822449, DOI: 10.1118/1.4811155, ISSN: 0094-2405.

Lai, Y, Sun, B, Ding, Z, Wang, J. Application of improved genetic algorithm in white matter tractography. 2013.

Holmes MJ, Yang X, Landman BA, Ding Z, Kang H, Abou-Khalil B, Sonmezturk HH, Gore JC, Morgan VL. Functional networks in temporal-lobe epilepsy: a voxel-wise study of resting-state functional connectivity and gray-matter concentration. Brain Connect [print-electronic]. 2013; 3(1): 22-30. PMID: 23150897, PMCID: PMC3621340, DOI: 10.1089/brain.2012.0103, ISSN: 2158-0022.

Ding Z, Newton AT, Xu R, Anderson AW, Morgan VL, Gore JC. Spatio-temporal correlation tensors reveal functional structure in human brain. PLoS ONE. 2013; 8(12): e82107. PMID: 24339997, PMCID: PMC3855380, PII: PONE-D-13-34417, DOI: 10.1371/journal.pone.0082107, ISSN: 1932-6203.

Gochberg DF, Ding Z. The approach to steady state using homogeneous and Cartesian coordinates. Comput Math Methods Med [print-electronic]. 2013; 2013: 729236. PMID: 23983812, PMCID: PMC3745872, DOI: 10.1155/2013/729236, ISSN: 1748-6718.

Eckstrand KL, Ding Z, Dodge NC, Cowan RL, Jacobson JL, Jacobson SW, Avison MJ. Persistent dose-dependent changes in brain structure in young adults with low-to-moderate alcohol exposure in utero. Alcohol. Clin. Exp. Res [print-electronic]. 2012 Nov; 36(11): 1892-902. PMID: 22594302, PMCID: PMC3424348, DOI: 10.1111/j.1530-0277.2012.01819.x, ISSN: 1530-0277.

Eckstrand KL, Ding Z, Dodge NC, Cowan RL, Jacobson JL, Jacobson SW, Avison MJ. Persistent dose-dependent changes in brain structure in young adults with low-to-moderate alcohol exposure in utero. Alcohol. Clin. Exp. Res [print-electronic]. 2012 Nov; 36(11): 1892-902. PMID: 22594302, PMCID: PMC3424348, DOI: 10.1111/j.1530-0277.2012.01819.x, ISSN: 1530-0277.

Kurtek S, Klassen E, Gore JC, Ding Z, Srivastava A. Elastic geodesic paths in shape space of parameterized surfaces. IEEE Trans Pattern Anal Mach Intell. 2012 Sep; 34(9): 1717-30. PMID: 22144521, DOI: 10.1109/TPAMI.2011.233, ISSN: 1939-3539.

Choe AS, Stepniewska I, Colvin DC, Ding Z, Anderson AW. Validation of diffusion tensor MRI in the central nervous system using light microscopy: quantitative comparison of fiber properties. NMR Biomed [print-electronic]. 2012 Jul; 25(7): 900-8. PMID: 22246940, DOI: 10.1002/nbm.1810, ISSN: 1099-1492.

Damon BM, Heemskerk AM, Ding Z. Polynomial fitting of DT-MRI fiber tracts allows accurate estimation of muscle architectural parameters. Magn Reson Imaging [print-electronic]. 2012 Jun; 30(5): 589-600. PMID: 22503094, PMCID: PMC3348398, PII: S0730-725X(12)00044-6, DOI: 10.1016/j.mri.2012.02.003, ISSN: 1873-5894.

Wu X, Xie M, Zhou J, Anderson AW, Gore JC, Ding Z. Globally optimized fiber tracking and hierarchical clustering -- a unified framework. Magn Reson Imaging [print-electronic]. 2012 May; 30(4): 485-95. PMID: 22285879, PMCID: PMC3327795, PII: S0730-725X(11)00479-6, DOI: 10.1016/j.mri.2011.12.017, ISSN: 1873-5894.

Sebastian Kurtek, Anuj Srivastava, Eric Klassen, and Zhaohua Ding. Statistical modelling of curves using shapes and related features. 2012.

Damon BM, Buck AK, Ding Z. Diffusion-Tensor MRI Based Skeletal Muscle Fiber Tracking. Imaging Med. 2011 Nov; 3(6): 675-87. PMID: 25429308, PMCID: PMC4241547, DOI: 10.2217/iim.11.60, ISSN: 1755-5191.

Li C, Huang R, Ding Z, Gatenby JC, Metaxas DN, Gore JC. A level set method for image segmentation in the presence of intensity inhomogeneities with application to MRI. IEEE Trans Image Process [print-electronic]. 2011 Jul; 20(7): 2007-16. PMID: 21518662, DOI: 10.1109/TIP.2011.2146190, ISSN: 1941-0042.

Englund EK, Elder CP, Xu Q, Ding Z, Damon BM. Combined diffusion and strain tensor MRI reveals a heterogeneous, planar pattern of strain development during isometric muscle contraction. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2011 May; 300(5): R1079-90. PMID: 21270344, PMCID: PMC3094039, PII: ajpregu.00474.2010, DOI: 10.1152/ajpregu.00474.2010, ISSN: 1522-1490.

Eapen M, Zald DH, Gatenby JC, Ding Z, Gore JC. Using high-resolution MR imaging at 7T to evaluate the anatomy of the midbrain dopaminergic system. AJNR Am J Neuroradiol [print-electronic]. 2011 Apr; 32(4): 688-94. PMID: 21183619, PMCID: PMC3076524, PII: ajnr.A2355, DOI: 10.3174/ajnr.A2355, ISSN: 1936-959X.

Kurtek S, Klassen E, Ding Z, Jacobson SW, Jacobson JL, Avison MJ, Srivastava A. Parameterization-invariant shape comparisons of anatomical surfaces. IEEE Trans Med Imaging [print-electronic]. 2011 Mar; 30(3): 849-58. PMID: 21156390, DOI: 10.1109/TMI.2010.2099130, ISSN: 1558-254X.

Weller RE, Stoeckel LE, Milby JB, Bolding M, Twieg DB, Knowlton RC, Avison MJ, Ding Z. Smaller regional gray matter volume in homeless african american cocaine-dependent men: a preliminary report. Open Neuroimag J [print-electronic]. 2011; 5: 57-64. PMID: 22135719, PMCID: PMC3227861, PII: TONIJ-5-57, DOI: 10.2174/1874440001105010057, ISSN: 1874-4400.

Damon, BM, Buck, AMK, Ding, Z. Diffusion-tensor MRI-based skeletal muscle fiber tracking. Imaging in Medicine. 2011; 3((6)): 675-87.

Mishra A, Anderson AW, Wu X, Gore JC, Ding Z. An improved Bayesian tensor regularization and sampling algorithm to track neuronal fiber pathways in the language circuit. Med Phys. 2010 Aug; 37(8): 4274-87. PMID: 20879588, PMCID: PMC2921424, ISSN: 0094-2405.

Heemskerk AM, Sinha TK, Wilson KJ, Ding Z, Damon BM. Repeatability of DTI-based skeletal muscle fiber tracking. NMR Biomed. 2010 Apr; 23(3): 294-303. PMID: 20099372, PMCID: PMC4416059, DOI: 10.1002/nbm.1463, ISSN: 1099-1492.

Xu Q, Anderson AW, Gore JC, Ding Z. Efficient anisotropic filtering of diffusion tensor images. Magn Reson Imaging [print-electronic]. 2010 Feb; 28(2): 200-11. PMID: 20061113, PMCID: PMC2824084, PII: S0730-725X(09)00279-3, DOI: 10.1016/j.mri.2009.10.001, ISSN: 1873-5894.

Wu X, Xu Q, Xu L, Zhou J, Anderson AW, Ding Z. Genetic white matter fiber tractography with global optimization. J. Neurosci. Methods [print-electronic]. 2009 Nov 11/15/2009; 184(2): 375-9. PMID: 19666052, PMCID: PMC3465964, PII: S0165-0270(09)00431-2, DOI: 10.1016/j.jneumeth.2009.07.032, ISSN: 1872-678X.

Xu Q, Anderson AW, Gore JC, Ding Z. Unified bundling and registration of brain white matter fibers. IEEE Trans Med Imaging [print-electronic]. 2009 Sep; 28(9): 1399-411. PMID: 19336300, PMCID: PMC3059198, DOI: 10.1109/TMI.2009.2016337, ISSN: 1558-254X.

Zhu H, Ding Z, Piana RN, Gehrig TR, Friedman MH. Cataloguing the geometry of the human coronary arteries: a potential tool for predicting risk of coronary artery disease. Int. J. Cardiol [print-electronic]. 2009 Jun 6/12/2009; 135(1): 43-52. PMID: 18597872, PMCID: PMC2759354, PII: S0167-5273(08)00480-4, DOI: 10.1016/j.ijcard.2008.03.087, ISSN: 1874-1754.

Woodward ND, Zald DH, Ding Z, Riccardi P, Ansari MS, Baldwin RM, Cowan RL, Li R, Kessler RM. Cerebral morphology and dopamine D2/D3 receptor distribution in humans: a combined [18F]fallypride and voxel-based morphometry study. Neuroimage [print-electronic]. 2009 May 5/15/2009; 46(1): 31-8. PMID: 19457373, PMCID: PMC2804466, PII: S1053-8119(09)00088-3, DOI: 10.1016/j.neuroimage.2009.01.049, ISSN: 1095-9572.

Kan JH, Heemskerk AM, Ding Z, Gregory A, Mencio G, Spindler K, Damon BM. DTI-based muscle fiber tracking of the quadriceps mechanism in lateral patellar dislocation. J Magn Reson Imaging. 2009 Mar; 29(3): 663-70. PMID: 19243049, PMCID: PMC2676427, DOI: 10.1002/jmri.21687, ISSN: 1053-1807.

Heemskerk AM, Sinha TK, Wilson KJ, Ding Z, Damon BM. Quantitative assessment of DTI-based muscle fiber tracking and optimal tracking parameters. Magn Reson Med. 2009 Feb; 61(2): 467-72. PMID: 19161166, PMCID: PMC2632726, DOI: 10.1002/mrm.21819, ISSN: 1522-2594.

Treadway MT, Grant MM, Ding Z, Hollon SD, Gore JC, Shelton RC. Early adverse events, HPA activity and rostral anterior cingulate volume in MDD. PLoS ONE [print-electronic]. 2009; 4(3): e4887. PMID: 19325704, PMCID: PMC2656617, DOI: 10.1371/journal.pone.0004887, ISSN: 1932-6203.

Morgan VL, Mishra A, Newton AT, Gore JC, Ding Z. Integrating functional and diffusion magnetic resonance imaging for analysis of structure-function relationship in the human language network. PLoS ONE. 2009; 4(8): e6660. PMID: 19684850, PMCID: PMC2721978, DOI: 10.1371/journal.pone.0006660, ISSN: 1932-6203.

Li C, Kao CY, Gore JC, Ding Z. Minimization of region-scalable fitting energy for image segmentation. IEEE Trans Image Process. 2008 Oct; 17(10): 1940-9. PMID: 18784040, PMCID: PMC2720140, DOI: 10.1109/TIP.2008.2002304, ISSN: 1057-7149.

Li C, Huang R, Ding Z, Gatenby C, Metaxas D, Gore J. A variational level set approach to segmentation and bias correction of images with intensity inhomogeneity. Med Image Comput Comput Assist Interv. 2008; 11(Pt 2): 1083-91. PMID: 18982712, PMCID: PMC2782702.

Lansdown DA, Ding Z, Wadington M, Hornberger JL, Damon BM. Quantitative diffusion tensor MRI-based fiber tracking of human skeletal muscle. J. Appl. Physiol [print-electronic]. 2007 Aug; 103(2): 673-81. PMID: 17446411, PMCID: PMC4440488, PII: 00290.2007, DOI: 10.1152/japplphysiol.00290.2007, ISSN: 8750-7587.

Mishra A, Lu Y, Choe AS, Aldroubi A, Gore JC, Anderson AW, Ding Z. An image-processing toolset for diffusion tensor tractography. Magn Reson Imaging [print-electronic]. 2007 Apr; 25(3): 365-76. PMID: 17371726, PMCID: PMC2719760, PII: S0730-725X(06)00328-6, DOI: 10.1016/j.mri.2006.10.006, ISSN: 0730-725X.

Mishra A, Lu Y, Meng J, Anderson AW, Ding Z. Unified framework for anisotropic interpolation and smoothing of diffusion tensor images. Neuroimage [print-electronic]. 2006 Jul 7/15/2006; 31(4): 1525-35. PMID: 16624586, PII: S1053-8119(06)00126-1, DOI: 10.1016/j.neuroimage.2006.02.031, ISSN: 1053-8119.

Lu Y, Aldroubi A, Gore JC, Anderson AW, Ding Z. Improved fiber tractography with Bayesian tensor regularization. Neuroimage [print-electronic]. 2006 Jul 7/1/2006; 31(3): 1061-74. PMID: 16563804, PII: S1053-8119(06)00087-5, DOI: 10.1016/j.neuroimage.2006.01.043, ISSN: 1053-8119.

Ding Z, Preiningerova J, Cannistraci CJ, Vollmer TL, Gore JC, Anderson AW. Quantification of multiple sclerosis lesion load and brain tissue volumetry using multiparameter MRI: methodology and reproducibility. Magn Reson Imaging. 2005 Apr; 23(3): 445-52. PMID: 15862645, PII: S0730-725X(05)00005-6, DOI: 10.1016/j.mri.2004.12.005, ISSN: 0730-725X.

Ding Z, Gore JC, Anderson AW. Reduction of noise in diffusion tensor images using anisotropic smoothing. Magn Reson Med. 2005 Feb; 53(2): 485-90. PMID: 15678537, DOI: 10.1002/mrm.20339, ISSN: 0740-3194.

Prosi M, Perktold K, Ding Z, Friedman MH. Influence of curvature dynamics on pulsatile coronary artery flow in a realistic bifurcation model. J Biomech. 2004 Nov; 37(11): 1767-75. PMID: 15388320, PII: S0021929004000533, DOI: 10.1016/j.jbiomech.2004.01.021, ISSN: 0021-9290.

Damon BM, Wigmore DM, Ding Z, Gore JC, Kent-Braun JA. Cluster analysis of muscle functional MRI data. J. Appl. Physiol [print-electronic]. 2003 Sep; 95(3): 1287-96. PMID: 12766178, PII: 00178.2003, DOI: 10.1152/japplphysiol.00178.2003, ISSN: 8750-7587.

Ding Z, Gore JC, Anderson AW. Classification and quantification of neuronal fiber pathways using diffusion tensor MRI. Magn Reson Med. 2003 Apr; 49(4): 716-21. PMID: 12652543, DOI: 10.1002/mrm.10415, ISSN: 0740-3194.

Zeng D, Ding Z, Friedman MH, Ethier CR. Effects of cardiac motion on right coronary artery hemodynamics. Ann Biomed Eng. 2003 Apr; 31(4): 420-9. PMID: 12723683, ISSN: 0090-6964.

Damon BM, Ding Z, Anderson AW, Freyer AS, Gore JC. Validation of diffusion tensor MRI-based muscle fiber tracking. Magn Reson Med. 2002 Jul; 48(1): 97-104. PMID: 12111936, DOI: 10.1002/mrm.10198, ISSN: 0740-3194.

Ding Z, Zhu H, Friedman MH. Coronary artery dynamics in vivo. Ann Biomed Eng. 2002 Apr; 30(4): 419-29. PMID: 12085995, ISSN: 0090-6964.

Ding Z, Friedman MH. Quantification of 3-D coronary arterial motion using clinical biplane cineangiograms. Int J Card Imaging. 2000 Oct; 16(5): 331-46. PMID: 11215918, ISSN: 0167-9899.

Ding Z, Friedman MH. Dynamics of human coronary arterial motion and its potential role in coronary atherogenesis. J Biomech Eng. 2000 Oct; 122(5): 488-92. PMID: 11091949, ISSN: 0148-0731.

Friedman MH, Ding Z. Variability of the planarity of the human aortic bifurcation. Med Eng Phys. 1998 Sep; 20(6): 469-72. PMID: 9796953, PII: S1350-4533(98)00039-3, ISSN: 1350-4533.

Friedman MH, Ding Z. Relation between the structural asymmetry of coronary branch vessels and the angle at their origin. J Biomech. 1998 Mar; 31(3): 273-8. PMID: 9645542, PII: S002192909800013X, ISSN: 0021-9290.

Ding Z, Biggs T, Seed WA, Friedman MH. Influence of the geometry of the left main coronary artery bifurcation on the distribution of sudanophilia in the daughter vessels. Arterioscler. Thromb. Vasc. Biol. 1997 Jul; 17(7): 1356-60. PMID: 9261267, ISSN: 1079-5642.

Friedman MH, Baker PB, Ding Z, Kuban BD. Relationship between the geometry and quantitative morphology of the left anterior descending coronary artery. Atherosclerosis. 1996 Sep 9/6/1996; 125(2): 183-92. PMID: 8842350, PII: 0021-9150(96)05869-8, ISSN: 0021-9150.