Seth R. Bordenstein, Ph.D.

Associate Professor

s.bordenstein@vanderbilt.edu

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Faculty Appointments
Associate Professor of Biological Sciences Associate Professor of Pathology, Microbiology and Immunology
Education
Ph.D., Evolutionary Genetics, University of Rochester, Rochester, New YorkM.S., Biology, University of Rochester, Rochester, New YorkB.S., Biology, University of Rochester, Rochester, New York
Office Address
Vanderbilt University, Department of Biological Sciences, VU Station B, Box 35-1634, Nashville, TN 37235
TN
Research Description
Our scholarship endeavors to understand “What are the evolutionary and genetic principles that shape interactions between animals and microbes, and what are the major consequences of these interactions?” Towards solving these questions, we employ hypothesis-driven approaches to study two forms of animal-microbe associations: intimate symbioses (between animals, obligate intracellular bacteria and bacteriophages) that impact animal reproduction and vector control, and facultative associations (between free-living organisms) that shape genome and species evolution across the tree of life. Our approaches leverage a wide range of expertise spanning virology, bacteriology, zoology, embryology, genetics, genomics, transcriptomics, ecology, evolution, development, and biochemistry. As symbiosis - the living together of dissimilar organisms - unites diverse subdisciplines in the life sciences, the lab’s scientific output produces both basic and translational outcomes.

Consistent federal funding supports the lab, including two current National Institutes of Health grants and a National Science Foundation grant. Over 90 total publication include recent research articles published in Current Biology, eLife, Nature, PLOS Biology, Proceedings of the National Academy of Sciences, and Science. Popular science productions including Atlantic, BBC Radio, CNN, Discover magazine, Huffington Post, The New York Times, PBS, and Scientific American covered this scholarship. Finally, it is important to note that the lab’s output happens with the energy, passion, and curiosity of dedicated and diverse young scientists (55 lab trainees in total from undergraduates to postdocs) who devote themselves to science and education. We are fortunate to work with a responsible and high-performance research group whose quality of expectations matches the quality of their output. Recent investigations study:

A. How does a bacteriophage underpin a global pandemic (Wolbachia) and a major vector control effort?

B. How do animals form relationships with intracellular and free-living bacteria?

C. How do microbes assist the origin of new host species?

D. What is the impact of ethnicity and diet on human gut microbiome viaraton and health disparities?

For more information, please contact Dr. Bordenstein and see the following online resources (we are recruiting students and postdocs):

Laboratory: http://bordensteinlab.vanderbilt.edu/
Twitter: @Symbionticism
Vanderbilt Microbiome Initiative: https://my.vanderbilt.edu/microbiome/
Science Education: https://my.vanderbilt.edu/discover/

Research Keywords
Symbiosis, Microbiome, Virology, Evolution, Genomics, Origin of Species
Publications
Perlmutter JI, Bordenstein SR. Microbial Misandry: Discovery of a Spiroplasma Male-Killing Toxin. Cell Host Microbe. 2018 Jun 6/13/2018; 23(6): 689-90. PMID: 29902429, PII: S1931-3128(18)30265-8, DOI: 10.1016/j.chom.2018.05.011, ISSN: 1934-6069.

Funkhouser-Jones LJ, van Opstal EJ, Sharma A, Bordenstein SR. The Maternal Effect Gene Wds Controls Wolbachia Titer in Nasonia. Curr. Biol [print-electronic]. 2018 Jun 6/4/2018; 28(11): 1692-1702.e6. PMID: 29779872, PMCID: PMC5988964, PII: S0960-9822(18)30438-X, DOI: 10.1016/j.cub.2018.04.010, ISSN: 1879-0445.

Shropshire JD, On J, Layton EM, Zhou H, Bordenstein SR. One prophage WO gene rescues cytoplasmic incompatibility in Drosophila melanogaster. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2018 May 5/8/2018; 115(19): 4987-91. PMID: 29686091, PMCID: PMC5948995, PII: 1800650115, DOI: 10.1073/pnas.1800650115, ISSN: 1091-6490.

Lindsey ARI, Rice DW, Bordenstein SR, Brooks AW, Bordenstein SR, Newton ILG. Evolutionary Genetics of Cytoplasmic Incompatibility Genes cifA and cifB in Prophage WO of Wolbachia. Genome Biol Evol. 2018 Feb 2/1/2018; 10(2): 434-51. PMID: 29351633, PMCID: PMC5793819, PII: 4815755, DOI: 10.1093/gbe/evy012, ISSN: 1759-6653.

Kohl KD, Dearing MD, Bordenstein SR. Microbial communities exhibit host species distinguishability and phylosymbiosis along the length of the gastrointestinal tract. Mol. Ecol [print-electronic]. 2017 Dec 12/11/2017; PMID: 29230893, DOI: 10.1111/mec.14460, ISSN: 1365-294X.

Kohl KD, Brun A, Bordenstein SR, Caviedes-Vidal E, Karasov WH. Gut microbes limit growth in House Sparrows nestlings (Passer domesticus), but not through limitations in digestive capacity. Integr Zool [print-electronic]. 2017 Nov 11/23/2017; PMID: 29168619, DOI: 10.1111/1749-4877.12289, ISSN: 1749-4877.

Long J, Cai Q, Steinwandel M, Hargreaves MK, Bordenstein SR, Blot WJ, Zheng W, Shu XO. Association of oral microbiome with type 2 diabetes risk. J. Periodont. Res [print-electronic]. 2017 Jun; 52(3): 636-43. PMID: 28177125, PMCID: PMC5403709, DOI: 10.1111/jre.12432, ISSN: 1600-0765.

Toribio-Fernández R, Bella JL, Martínez-Rodríguez P, Funkhouser-Jones LJ, Bordenstein SR, Pita M. Chromosomal localization of Wolbachia inserts in the genomes of two subspecies of Chorthippus parallelus forming a Pyrenean hybrid zone. Chromosome Res [print-electronic]. 2017 May 5/5/2017; PMID: 28477267, PII: 10.1007/s10577-017-9557-9, DOI: 10.1007/s10577-017-9557-9, ISSN: 1573-6849.

LePage DP, Metcalf JA, Bordenstein SR, On J, Perlmutter JI, Shropshire JD, Layton EM, Funkhouser-Jones LJ, Beckmann JF, Bordenstein SR. Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility. Nature [print-electronic]. 2017 Mar 3/9/2017; 543(7644): 243-7. PMID: 28241146, PMCID: PMC5358093, PII: nature21391, DOI: 10.1038/nature21391, ISSN: 1476-4687.

Kohl KD, Brun A, Magallanes M, Brinkerhoff J, Laspiur A, Acosta JC, Caviedes-Vidal E, Bordenstein SR. Gut microbial ecology of lizards: insights into diversity in the wild, effects of captivity, variation across gut regions and transmission. Mol. Ecol [print-electronic]. 2017 Feb; 26(4): 1175-89. PMID: 27862531, DOI: 10.1111/mec.13921, ISSN: 1365-294X.

Saulsberry A, Pinchas M, Noll A, Lynch JA, Bordenstein SR, Brucker RM. Establishment of F1 hybrid mortality in real time. BMC Evol. Biol. 2017 Jan 1/26/2017; 17(1): 37. PMID: 28125957, PMCID: PMC5270250, PII: 10.1186/s12862-017-0879-1, DOI: 10.1186/s12862-017-0879-1, ISSN: 1471-2148.

Bordenstein SR, Bordenstein SR. Eukaryotic association module in phage WO genomes from Wolbachia. Nat Commun. 2016 Oct 10/11/2016; 7: 13155. PMID: 27727237, PMCID: PMC5062602, PII: ncomms13155, DOI: 10.1038/ncomms13155, ISSN: 2041-1723.

Bojanova DP, Bordenstein SR. Fecal Transplants: What Is Being Transferred?. PLoS Biol. 2016 Jul; 14(7): e1002503. PMID: 27404502, PMCID: PMC4942072, PII: PBIOLOGY-D-16-00865, DOI: 10.1371/journal.pbio.1002503, ISSN: 1545-7885.

Kohl KD, Brun A, Magallanes M, Brinkerhoff J, Laspiur A, Acosta JC, Bordenstein SR, Caviedes-Vidal E. Physiological and microbial adjustments to diet quality permit facultative herbivory in an omnivorous lizard. J. Exp. Biol. 2016 Jun 6/15/2016; 219(Pt 12): 1903-12. PMID: 27307545, PII: 219/12/1903, DOI: 10.1242/jeb.138370, ISSN: 1477-9145.

Lindsey AR, Bordenstein SR, Newton IL, Rasgon JL. Wolbachia pipientis should not be split into multiple species: A response to Ramírez-Puebla et al., "Species in Wolbachia? Proposal for the designation of 'Candidatus Wolbachia bourtzisii', 'Candidatus Wolbachia onchocercicola', 'Candidatus Wolbachia blaxteri', 'Candidatus Wolbachia brugii', 'Candidatus Wolbachia taylori', 'Candidatus Wolbachia collembolicola' and 'Candidatus Wolbachia multihospitum' for the different species within Wolbachia supergroups". Syst. Appl. Microbiol [print-electronic]. 2016 May; 39(3): 220-2. PMID: 27021523, PII: S0723-2020(16)00036-9, DOI: 10.1016/j.syapm.2016.03.001, ISSN: 1618-0984.

Dobson SL, Bordenstein SR, Rose RI. Wolbachia mosquito control: Regulated [letter]. Science. 2016 Apr 4/29/2016; 352(6285): 526-7. PMID: 27126029, PII: 352/6285/526-b, DOI: 10.1126/science.352.6285.526-b, ISSN: 1095-9203.

Theis KR, Dheilly NM, Klassen JL, Brucker RM, Baines JF, Bosch TC, Cryan JF, Gilbert SF, Goodnight CJ, Lloyd EA, Sapp J, Vandenkoornhuyse P, Zilber-Rosenberg I, Rosenberg E, Bordenstein SR. Getting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their Microbiomes. MSystems. 2016 Mar; 1(2): PMID: 27822520, PMCID: PMC5069740, PII: mSystems00028-16, DOI: 10.1128/mSystems.00028-16, ISSN: 2379-5077.

Theis KR, Dheilly NM, Klassen JL, Brucker RM, Baines JF, Bosch TC, Cryan JF, Gilbert SF, Goodnight CJ, Lloyd EA, Sapp J, Vandenkoornhuyse P, Zilber-Rosenberg I, Rosenberg E, Bordenstein SR. Getting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their Microbiomes. MSystems. 2016 Mar; 1(2): PMID: 27822520, PMCID: PMC5069740, PII: mSystems00028-16, DOI: 10.1128/mSystems.00028-16, ISSN: 2379-5077.

Shropshire JD, Bordenstein SR. Speciation by Symbiosis: the Microbiome and Behavior. MBio. 2016; 7(2): e01785. PMID: 27034284, PMCID: PMC4817261, PII: mBio.01785-15, DOI: 10.1128/mBio.01785-15, ISSN: 2150-7511.

Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV. Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency. Nat Commun. 2016; 7: 11240. PMID: 27046438, PMCID: PMC4822073, PII: ncomms11240, DOI: 10.1038/ncomms11240, ISSN: 2041-1723.

Newton IL, Clark ME, Kent BN, Bordenstein SR, Qu J, Richards S, Kelkar YD, Werren JH. Comparative Genomics of Two Closely Related Wolbachia with Different Reproductive Effects on Hosts. Genome Biol Evol. 2016; 8(5): 1526-42. PMID: 27189996, PMCID: PMC4898810, PII: evw096, DOI: 10.1093/gbe/evw096, ISSN: 1759-6653.

Dittmer J, van Opstal EJ, Shropshire JD, Bordenstein SR, Hurst GD, Brucker RM. Disentangling a Holobiont - Recent Advances and Perspectives in Nasonia Wasps. Front Microbiol. 2016; 7: 1478. PMID: 27721807, PMCID: PMC5033955, DOI: 10.3389/fmicb.2016.01478, ISSN: 1664-302X.

Shropshire JD, van Opstal EJ, Bordenstein SR. An optimized approach to germ-free rearing in the jewel wasp Nasonia. PeerJ. 2016; 4: e2316. PMID: 27602283, PMCID: PMC4991892, PII: 2316, DOI: 10.7717/peerj.2316, ISSN: 2167-8359.

Dittmer J, van Opstal EJ, Shropshire JD, Bordenstein SR, Hurst GD, Brucker RM. Disentangling a Holobiont - Recent Advances and Perspectives in Nasonia Wasps. Front Microbiol. 2016; 7: 1478. PMID: 27721807, PMCID: PMC5033955, DOI: 10.3389/fmicb.2016.01478, ISSN: 1664-302X.

Shropshire JD, van Opstal EJ, Bordenstein SR. An optimized approach to germ-free rearing in the jewel wasp Nasonia. PeerJ. 2016; 4: e2316. PMID: 27602283, PMCID: PMC4991892, PII: 2316, DOI: 10.7717/peerj.2316, ISSN: 2167-8359.

van Opstal EJ, Bordenstein SR. MICROBIOME. Rethinking heritability of the microbiome. Science. 2015 Sep 9/11/2015; 349(6253): 1172-3. PMID: 26359393, PII: 349/6253/1172, DOI: 10.1126/science.aab3958, ISSN: 1095-9203.

Bordenstein SR, Theis KR. Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes. PLoS Biol. 2015 Aug; 13(8): e1002226. PMID: 26284777, PMCID: PMC4540581, PII: PBIOLOGY-D-15-01003, DOI: 10.1371/journal.pbio.1002226, ISSN: 1545-7885.

Jernigan KK, Bordenstein SR. Tandem-repeat protein domains across the tree of life. PeerJ. 2015; 3: e732. PMID: 25653910, PMCID: PMC4304861, PII: 732, DOI: 10.7717/peerj.732, ISSN: 2167-8359.

Flynn CR, Albaugh VL, Cai S, Cheung-Flynn J, Williams PE, Brucker RM, Bordenstein SR, Guo Y, Wasserman DH, Abumrad NN. Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Nat Commun. 2015; 6: 7715. PMID: 26197299, PMCID: PMC4518285, PII: ncomms8715, DOI: 10.1038/ncomms8715, ISSN: 2041-1723.

Jernigan KK, Bordenstein SR. Tandem-repeat protein domains across the tree of life. PeerJ. 2015; 3: e732. PMID: 25653910, PMCID: PMC4304861, PII: 732, DOI: 10.7717/peerj.732, ISSN: 2167-8359.

Funkhouser-Jones LJ, Sehnert SR, Martínez-Rodríguez P, Toribio-Fernández R, Pita M, Bella JL, Bordenstein SR. Wolbachia co-infection in a hybrid zone: discovery of horizontal gene transfers from two Wolbachia supergroups into an animal genome. PeerJ. 2015; 3: e1479. PMID: 26664808, PMCID: PMC4675112, PII: 1479, DOI: 10.7717/peerj.1479, ISSN: 2167-8359.

Bordenstein SR. Genomic and cellular complexity from symbiotic simplicity. Cell. 2014 Sep 9/11/2014; 158(6): 1236-7. PMID: 25215482, PMCID: PMC4689137, PII: S0092-8674(14)01054-X, DOI: 10.1016/j.cell.2014.08.022, ISSN: 1097-4172.

Romano-Keeler J, Moore DJ, Wang C, Brucker RM, Fonnesbeck C, Slaughter JC, Li H, Curran DP, Meng S, Correa H, Lovvorn HN, Tang YW, Bordenstein S, George AL, Weitkamp JH. Early life establishment of site-specific microbial communities in the gut. Gut Microbes [print-electronic]. 2014 Mar; 5(2): 192-201. PMID: 24637795, PMCID: PMC4063844, PII: 28442, DOI: 10.4161/gmic.28442, ISSN: 1949-0984.

Jernigan KK, Bordenstein SR. Ankyrin domains across the Tree of Life. PeerJ. 2014; 2: e264. PMID: 24688847, PMCID: PMC3932732, PII: 264, DOI: 10.7717/peerj.264, ISSN: 2167-8359.

LePage DP, Jernigan KK, Bordenstein SR. The relative importance of DNA methylation and Dnmt2-mediated epigenetic regulation on Wolbachia densities and cytoplasmic incompatibility. PeerJ. 2014; 2: e678. PMID: 25538866, PMCID: PMC4266856, PII: 678, DOI: 10.7717/peerj.678, ISSN: 2167-8359.

Metcalf JA, Funkhouser-Jones LJ, Brileya K, Reysenbach AL, Bordenstein SR. Antibacterial gene transfer across the tree of life. Elife. 2014; 3: PMID: 25422936, PMCID: PMC4241558, DOI: 10.7554/eLife.04266, ISSN: 2050-084X.

Stilling RM, Bordenstein SR, Dinan TG, Cryan JF. Friends with social benefits: host-microbe interactions as a driver of brain evolution and development?. Front Cell Infect Microbiol. 2014; 4: 147. PMID: 25401092, PMCID: PMC4212686, DOI: 10.3389/fcimb.2014.00147, ISSN: 2235-2988.

Metcalf JA, Jo M, Bordenstein SR, Jaenike J, Bordenstein SR. Recent genome reduction of Wolbachia in Drosophila recens targets phage WO and narrows candidates for reproductive parasitism. PeerJ. 2014; 2: e529. PMID: 25165636, PMCID: PMC4137656, PII: 529, DOI: 10.7717/peerj.529, ISSN: 2167-8359.

Metcalf JA, Funkhouser-Jones LJ, Brileya K, Reysenbach AL, Bordenstein SR. Antibacterial gene transfer across the tree of life. Elife. 2014; 3: PMID: 25422936, PMCID: PMC4241558, DOI: 10.7554/eLife.04266, ISSN: 2050-084X.

Jernigan KK, Bordenstein SR. Ankyrin domains across the Tree of Life. PeerJ. 2014; 2: e264. PMID: 24688847, PMCID: PMC3932732, PII: 264, DOI: 10.7717/peerj.264, ISSN: 2167-8359.

Brucker RM, Bordenstein SR. The capacious hologenome. Zoology (Jena) [print-electronic]. 2013 Oct; 116(5): 260-1. PMID: 24035647, PII: S0944-2006(13)00071-8, DOI: 10.1016/j.zool.2013.08.003, ISSN: 1873-2720.

Brucker RM, Bordenstein SR. The hologenomic basis of speciation: gut bacteria cause hybrid lethality in the genus Nasonia. Science [print-electronic]. 2013 Aug 8/9/2013; 341(6146): 667-9. PMID: 23868918, PII: science.1240659, DOI: 10.1126/science.1240659, ISSN: 1095-9203.

LePage D, Bordenstein SR. Wolbachia: Can we save lives with a great pandemic?. Trends Parasitol [print-electronic]. 2013 Aug; 29(8): 385-93. PMID: 23845310, PMCID: PMC3775348, PII: S1471-4922(13)00101-3, DOI: 10.1016/j.pt.2013.06.003, ISSN: 1471-5007.

Funkhouser LJ, Bordenstein SR. Mom knows best: the universality of maternal microbial transmission. PLoS Biol [print-electronic]. 2013; 11(8): e1001631. PMID: 23976878, PMCID: PMC3747981, PII: PBIOLOGY-D-13-00579, DOI: 10.1371/journal.pbio.1001631, ISSN: 1545-7885.

Duncan SS, Valk PL, McClain MS, Shaffer CL, Metcalf JA, Bordenstein SR, Cover TL. Comparative genomic analysis of East Asian and non-Asian Helicobacter pylori strains identifies rapidly evolving genes. PLoS ONE [print-electronic]. 2013; 8(1): e55120. PMID: 23383074, PMCID: PMC3561388, PII: PONE-D-12-28737, DOI: 10.1371/journal.pone.0055120, ISSN: 1932-6203.

Metcalf JA, Bordenstein SR. The complexity of virus systems: the case of endosymbionts. Curr. Opin. Microbiol [print-electronic]. 2012 Aug; 15(4): 546-52. PMID: 22609369, PMCID: PMC3424318, PII: S1369-5274(12)00053-7, DOI: 10.1016/j.mib.2012.04.010, ISSN: 1879-0364.

Brucker RM, Bordenstein SR. Speciation by symbiosis. Trends Ecol. Evol. (Amst.) [print-electronic]. 2012 Aug; 27(8): 443-51. PMID: 22541872, PII: S0169-5347(12)00076-6, DOI: 10.1016/j.tree.2012.03.011, ISSN: 1872-8383.

Metcalf JA, Bordenstein SR. The complexity of virus systems: the case of endosymbionts. Curr. Opin. Microbiol [print-electronic]. 2012 Aug; 15(4): 546-52. PMID: 22609369, PMCID: PMC3424318, PII: S1369-5274(12)00053-7, DOI: 10.1016/j.mib.2012.04.010, ISSN: 1879-0364.

Duncan SS, Valk PL, Shaffer CL, Bordenstein SR, Cover TL. J-Western forms of Helicobacter pylori cagA constitute a distinct phylogenetic group with a widespread geographic distribution. J. Bacteriol [print-electronic]. 2012 Mar; 194(6): 1593-604. PMID: 22247512, PMCID: PMC3294863, PII: JB.06340-11, DOI: 10.1128/JB.06340-11, ISSN: 1098-5530.

Brucker RM, Bordenstein SR. The roles of host evolutionary relationships (genus: Nasonia) and development in structuring microbial communities. Evolution [print-electronic]. 2012 Feb; 66(2): 349-62. PMID: 22276533, DOI: 10.1111/j.1558-5646.2011.01454.x, ISSN: 1558-5646.

Brucker RM, Funkhouser LJ, Setia S, Pauly R, Bordenstein SR. Insect Innate Immunity Database (IIID): an annotation tool for identifying immune genes in insect genomes. PLoS ONE [print-electronic]. 2012; 7(9): e45125. PMID: 22984621, PMCID: PMC3440344, PII: PONE-D-12-12283, DOI: 10.1371/journal.pone.0045125, ISSN: 1932-6203.

Brucker RM, Bordenstein SR. In vitro cultivation of the hymenoptera genetic model, Nasonia. PLoS ONE [print-electronic]. 2012; 7(12): e51269. PMID: 23227258, PMCID: PMC3515518, PII: PONE-D-12-25671, DOI: 10.1371/journal.pone.0051269, ISSN: 1932-6203.

Rosengaus RB, Zecher CN, Schultheis KF, Brucker RM, Bordenstein SR. Disruption of the termite gut microbiota and its prolonged consequences for fitness. Appl. Environ. Microbiol [print-electronic]. 2011 Jul; 77(13): 4303-12. PMID: 21571887, PMCID: PMC3127728, PII: AEM.01886-10, DOI: 10.1128/AEM.01886-10, ISSN: 1098-5336.

Newton IL, Bordenstein SR. Correlations between bacterial ecology and mobile DNA. Curr. Microbiol [print-electronic]. 2011 Jan; 62(1): 198-208. PMID: 20577742, PMCID: PMC3006647, DOI: 10.1007/s00284-010-9693-3, ISSN: 1432-0991.

Chafee ME, Zecher CN, Gourley ML, Schmidt VT, Chen JH, Bordenstein SR, Clark ME, Bordenstein SR. Decoupling of host-symbiont-phage coadaptations following transfer between insect species. Genetics [print-electronic]. 2011 Jan; 187(1): 203-15. PMID: 20944019, PMCID: PMC3018312, PII: genetics.110.120675, DOI: 10.1534/genetics.110.120675, ISSN: 1943-2631.

Bordenstein SR, Bordenstein SR. Temperature affects the tripartite interactions between bacteriophage WO, Wolbachia, and cytoplasmic incompatibility. PLoS ONE [print-electronic]. 2011; 6(12): e29106. PMID: 22194999, PMCID: PMC3240643, PII: PONE-D-11-17756, DOI: 10.1371/journal.pone.0029106, ISSN: 1932-6203.

Kent BN, Funkhouser LJ, Setia S, Bordenstein SR. Evolutionary genomics of a temperate bacteriophage in an obligate intracellular bacteria (Wolbachia). PLoS ONE [print-electronic]. 2011; 6(9): e24984. PMID: 21949820, PMCID: PMC3173496, PII: PONE-D-11-12137, DOI: 10.1371/journal.pone.0024984, ISSN: 1932-6203.

Kent BN, Salichos L, Gibbons JG, Rokas A, Newton IL, Clark ME, Bordenstein SR. Complete bacteriophage transfer in a bacterial endosymbiont (Wolbachia) determined by targeted genome capture. Genome Biol Evol [print-electronic]. 2011; 3: 209-18. PMID: 21292630, PMCID: PMC3068000, PII: evr007, DOI: 10.1093/gbe/evr007, ISSN: 1759-6653.

Gangwer KA, Shaffer CL, Suerbaum S, Lacy DB, Cover TL, Bordenstein SR. Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA. J. Bacteriol [print-electronic]. 2010 Dec; 192(23): 6126-35. PMID: 20870762, PMCID: PMC2981223, PII: JB.01081-10, DOI: 10.1128/JB.01081-10, ISSN: 1098-5530.

Kent BN, Bordenstein SR. Phage WO of Wolbachia: lambda of the endosymbiont world. Trends Microbiol [print-electronic]. 2010 Apr; 18(4): 173-81. PMID: 20083406, PMCID: PMC2862486, PII: S0966-842X(09)00270-4, DOI: 10.1016/j.tim.2009.12.011, ISSN: 1878-4380.

Chafee ME, Funk DJ, Harrison RG, Bordenstein SR. Lateral phage transfer in obligate intracellular bacteria (wolbachia): verification from natural populations. Mol. Biol. Evol [print-electronic]. 2010 Mar; 27(3): 501-5. PMID: 19906794, PMCID: PMC2822291, PII: msp275, DOI: 10.1093/molbev/msp275, ISSN: 1537-1719.

Werren JH, Richards S, Desjardins CA, Niehuis O, Gadau J, Colbourne JK, , Werren JH, Richards S, Desjardins CA, Niehuis O, Gadau J, Colbourne JK, Beukeboom LW, Desplan C, Elsik CG, Grimmelikhuijzen CJ, Kitts P, Lynch JA, Murphy T, Oliveira DC, Smith CD, van de Zande L, Worley KC, Zdobnov EM, Aerts M, Albert S, Anaya VH, Anzola JM, Barchuk AR, Behura SK, Bera AN, Berenbaum MR, Bertossa RC, Bitondi MM, Bordenstein SR, Bork P, Bornberg-Bauer E, Brunain M, Cazzamali G, Chaboub L, Chacko J, Chavez D, Childers CP, Choi JH, Clark ME, Claudianos C, Clinton RA, Cree AG, Cristino AS, Dang PM, Darby AC, de Graaf DC, Devreese B, Dinh HH, Edwards R, Elango N, Elhaik E, Ermolaeva O, Evans JD, Foret S, Fowler GR, Gerlach D, Gibson JD, Gilbert DG, Graur D, Gründer S, Hagen DE, Han Y, Hauser F, Hultmark D, Hunter HC, Hurst GD, Jhangian SN, Jiang H, Johnson RM, Jones AK, Junier T, Kadowaki T, Kamping A, Kapustin Y, Kechavarzi B, Kim J, Kim J, Kiryutin B, Koevoets T, Kovar CL, Kriventseva EV, Kucharski R, Lee H, Lee SL, Lees K, Lewis LR, Loehlin DW, Logsdon JM, Lopez JA, Lozado RJ, Maglott D, Maleszka R, Mayampurath A, Mazur DJ, McClure MA, Moore AD, Morgan MB, Muller J, Munoz-Torres MC, Muzny DM, Nazareth LV, Neupert S, Nguyen NB, Nunes FM, Oakeshott JG, Okwuonu GO, Pannebakker BA, Pejaver VR, Peng Z, Pratt SC, Predel R, Pu LL, Ranson H, Raychoudhury R, Rechtsteiner A, Reese JT, Reid JG, Riddle M, Robertson HM, Romero-Severson J, Rosenberg M, Sackton TB, Sattelle DB, Schlüns H, Schmitt T, Schneider M, Schüler A, Schurko AM, Shuker DM, Simões ZL, Sinha S, Smith Z, Solovyev V, Souvorov A, Springauf A, Stafflinger E, Stage DE, Stanke M, Tanaka Y, Telschow A, Trent C, Vattathil S, Verhulst EC, Viljakainen L, Wanner KW, Waterhouse RM, Whitfield JB, Wilkes TE, Williamson M, Willis JH, Wolschin F, Wyder S, Yamada T, Yi SV, Zecher CN, Zhang L, Gibbs RA. Functional and evolutionary insights from the genomes of three parasitoid Nasonia species. Science. 2010 Jan 1/15/2010; 327(5963): 343-8. PMID: 20075255, PMCID: PMC2849982, PII: 327/5963/343, DOI: 10.1126/science.1178028, ISSN: 1095-9203.

Ishmael N, Dunning Hotopp JC, Ioannidis P, Biber S, Sakamoto J, Siozios S, Nene V, Werren J, Bourtzis K, Bordenstein SR, Tettelin H. Extensive genomic diversity of closely related Wolbachia strains. Microbiology (Reading, Engl.) [print-electronic]. 2009 Jul; 155(Pt 7): 2211-22. PMID: 19389774, PMCID: PMC2888116, PII: mic.0.027581-0, DOI: 10.1099/mic.0.027581-0, ISSN: 1350-0872.

Bordenstein SR, Paraskevopoulos C, Dunning Hotopp JC, Sapountzis P, Lo N, Bandi C, Tettelin H, Werren JH, Bourtzis K. Parasitism and mutualism in Wolbachia: what the phylogenomic trees can and cannot say. Mol. Biol. Evol [print-electronic]. 2009 Jan; 26(1): 231-41. PMID: 18974066, PMCID: PMC2721558, PII: msn243, DOI: 10.1093/molbev/msn243, ISSN: 1537-1719.

Bordenstein SR. Evolutionary genomics: transdomain gene transfers. Curr. Biol. 2007 Nov 11/6/2007; 17(21): R935-6. PMID: 17983575, PII: S0960-9822(07)01981-1, DOI: 10.1016/j.cub.2007.09.022, ISSN: 0960-9822.

Bordenstein SR, Werren JH. Bidirectional incompatibility among divergent Wolbachia and incompatibility level differences among closely related Wolbachia in Nasonia. Heredity (Edinb) [print-electronic]. 2007 Sep; 99(3): 278-87. PMID: 17519968, PII: 6800994, DOI: 10.1038/sj.hdy.6800994, ISSN: 0018-067X.

Sanogo YO, Dobson SL, Bordenstein SR, Novak RJ. Disruption of the Wolbachia surface protein gene wspB by a transposable element in mosquitoes of the Culex pipiens complex (Diptera, Culicidae). Insect Mol. Biol [print-electronic]. 2007 Apr; 16(2): 143-54. PMID: 17298560, PII: IMB707, DOI: 10.1111/j.1365-2583.2006.00707.x, ISSN: 0962-1075.

Lo N, Paraskevopoulos C, Bourtzis K, O'Neill SL, Werren JH, Bordenstein SR, Bandi C. Taxonomic status of the intracellular bacterium Wolbachia pipientis. Int. J. Syst. Evol. Microbiol. 2007 Mar; 57(Pt 3): 654-7. PMID: 17329802, PII: 57/3/654, DOI: 10.1099/ijs.0.64515-0, ISSN: 1466-5026.

Ioannidis P, Dunning Hotopp JC, Sapountzis P, Siozios S, Tsiamis G, Bordenstein SR, Baldo L, Werren JH, Bourtzis K. New criteria for selecting the origin of DNA replication in Wolbachia and closely related bacteria. BMC Genomics. 2007; 8: 182. PMID: 17584494, PMCID: PMC1914354, PII: 1471-2164-8-182, DOI: 10.1186/1471-2164-8-182, ISSN: 1471-2164.

Bordenstein, SR. Discover the Microbes Within! The Wolbachia Project. Focus on Microbiology Education. 2007; 14((1)): 4-5.

Paraskevopoulos C, Bordenstein SR, Wernegreen JJ, Werren JH, Bourtzis K. Toward a Wolbachia multilocus sequence typing system: discrimination of Wolbachia strains present in Drosophila species. Curr. Microbiol [print-electronic]. 2006 Nov; 53(5): 388-95. PMID: 17036209, DOI: 10.1007/s00284-006-0054-1, ISSN: 0343-8651.

Baldo L, Dunning Hotopp JC, Jolley KA, Bordenstein SR, Biber SA, Choudhury RR, Hayashi C, Maiden MC, Tettelin H, Werren JH. Multilocus sequence typing system for the endosymbiont Wolbachia pipientis. Appl. Environ. Microbiol [print-electronic]. 2006 Nov; 72(11): 7098-110. PMID: 16936055, PMCID: PMC1636189, PII: AEM.00731-06, DOI: 10.1128/AEM.00731-06, ISSN: 0099-2240.

Bordenstein SR, Marshall ML, Fry AJ, Kim U, Wernegreen JJ. The tripartite associations between bacteriophage, Wolbachia, and arthropods. PLoS Pathog [print-electronic]. 2006 May; 2(5): e43. PMID: 16710453, PMCID: PMC1463016, DOI: 10.1371/journal.ppat.0020043, ISSN: 1553-7374.

Baldo L, Bordenstein S, Wernegreen JJ, Werren JH. Widespread recombination throughout Wolbachia genomes. Mol. Biol. Evol [print-electronic]. 2006 Feb; 23(2): 437-49. PMID: 16267140, PII: msj049, DOI: 10.1093/molbev/msj049, ISSN: 0737-4038.

Casiraghi M, Bordenstein SR, Baldo L, Lo N, Beninati T, Wernegreen JJ, Werren JH, Bandi C. Phylogeny of Wolbachia pipientis based on gltA, groEL and ftsZ gene sequences: clustering of arthropod and nematode symbionts in the F supergroup, and evidence for further diversity in the Wolbachia tree. Microbiology (Reading, Engl.). 2005 Dec; 151(Pt 12): 4015-22. PMID: 16339946, PII: 151/12/4015, DOI: 10.1099/mic.0.28313-0, ISSN: 1350-0872.

Bordenstein S, Rosengaus RB. Discovery of a novel Wolbachia super group in Isoptera. Curr. Microbiol [print-electronic]. 2005 Dec; 51(6): 393-8. PMID: 16252129, DOI: 10.1007/s00284-005-0084-0, ISSN: 0343-8651.

Bordenstein SR, Reznikoff WS. Mobile DNA in obligate intracellular bacteria. Nat. Rev. Microbiol. 2005 Sep; 3(9): 688-99. PMID: 16138097, PII: nrmicro1233, DOI: 10.1038/nrmicro1233, ISSN: 1740-1526.

Reznikoff WS, Bordenstein SR, Apodaca J. Comparative sequence analysis of IS50/Tn5 transposase. J. Bacteriol. 2004 Dec; 186(24): 8240-7. PMID: 15576772, PMCID: PMC532410, PII: 186/24/8240, DOI: 10.1128/JB.186.24.8240-8247.2004, ISSN: 0021-9193.

Bordenstein SR, Wernegreen JJ. Bacteriophage flux in endosymbionts (Wolbachia): infection frequency, lateral transfer, and recombination rates. Mol. Biol. Evol [print-electronic]. 2004 Oct; 21(10): 1981-91. PMID: 15254259, PII: msh211, DOI: 10.1093/molbev/msh211, ISSN: 0737-4038.

Bordenstein SR, Fitch DH, Werren JH. Absence of wolbachia in nonfilariid nematodes. J. Nematol. 2003 Sep; 35(3): 266-70. PMID: 19262760, PMCID: PMC2620650, ISSN: 0022-300X.

Bordenstein SR, Uy JJ, Werren JH. Host genotype determines cytoplasmic incompatibility type in the haplodiploid genus Nasonia. Genetics. 2003 May; 164(1): 223-33. PMID: 12750334, PMCID: PMC1462542, ISSN: 0016-6731.

Wernegreen JJ, Degnan PH, Lazarus AB, Palacios C, Bordenstein SR. Genome evolution in an insect cell: distinct features of an ant-bacterial partnership. Biol. Bull. 2003 Apr; 204(2): 221-31. PMID: 12700158, ISSN: 0006-3185.

Bordenstein, SR. Symbiosis and the Origin of Species. In Insect Symbiosis. 2003; 2: 283-304.

Bordenstein SR, O'Hara FP, Werren JH. Wolbachia-induced incompatibility precedes other hybrid incompatibilities in Nasonia. Nature. 2001 Feb 2/8/2001; 409(6821): 707-10. PMID: 11217858, DOI: 10.1038/35055543, ISSN: 0028-0836.

Bordenstein SR, Drapeau MD, Werren JH. Intraspecific variation in sexual isolation in the jewel wasp Nasonia. Evolution. 2000 Apr; 54(2): 567-73. PMID: 10937233, ISSN: 0014-3820.

Bordenstein SR, Werren JH. Do Wolbachia influence fecundity in Nasonia vitripennis?. Heredity (Edinb). 2000 Jan; 84 ( Pt 1): 54-62. PMID: 10692011, PII: her637, ISSN: 0018-067X.

Bordenstein SR, Werren JH. Effects of A and B Wolbachia and host genotype on interspecies cytoplasmic incompatibility in Nasonia. Genetics. 1998 Apr; 148(4): 1833-44. PMID: 9560398, PMCID: PMC1460083, ISSN: 0016-6731.

Available Postdoctoral Position Details
Posted: 2/9/2016
General Ad: The Bordenstein Lab in the Department of Biological Sciences and Pathology, Microbiology and Immunology at Vanderbilt University in Nashville, TN is always seeking passionate and self-motivated postdocs, preferably self-funded, in the areas of symbiotic interactions or evolution.


To apply, please send a single pdf including a cover letter stating career interests, research strengths, areas to develop, earliest start date, curriculum vitae, an example publication, and contact information for three or more references to s.bordenstein@vanderbilt.edu.

More information about the Bordenstein lab can be found at. http://bordensteinlab.vanderbilt.edu

Vanderbilt University campus is a National Arboretum located in the heart of Nashville, the capital of Tennessee. Known internationally as Music City USA, Nashville is also the home to professional sports teams, the Nashville Symphony, the Frist Center for the Visual Arts, and numerous activities for outdoor enthusiasts. Nashville is a wonderful place to live, work, and raise a family. Education required: * PhD in bioinformatics, symbiosis, genetics, microscopy, evolutionary biology or closely related fields.