Faculty Appointments
Professor of Ophthalmology and Visual Sciences
Professor of PsychologyDenis M. O'Day, M.B.B.S., Chair in Ophthalmology and Visual SciencesProfessor of Pharmacology
Education
Ph.D., Neurosciences, University of Pennsylvania, Philadelphia, PennsylvaniaB.S., University of Michigan, Ann Arbor, Michigan
Office Address
11435 MRB IV
2215B Garland Avenue
Nashville, TN 37232-8808
2215B Garland Avenue
Nashville, TN 37232-8808
Research Description
David J. Calkins, PhD, is the Vice President for Research and the Denis M. O’Day Professor of Ophthalmology & Visual Sciences at Vanderbilt University Medical Center in Nashville, TN, where he also serves as Vice Chair for Strategy for the Vanderbilt Eye Institute. As a leading authority on the neurobiological roots of vision loss and blindness, Dr. Calkins’s research focuses on the pathogenesis of optic nerve and retinal degeneration in age-related diseases. Dr. Calkins leverages his expertise in ion channel physiology, cellular imaging, and systems neuroscience to reveal how critical interactions between neurons, glial cells, and vascular elements contribute to loss of function. His research has led to identification of novel targets for therapies based on neuronal protection, repair, and regeneration. Several of these are now in clinical trials for both chronic and inherited optic neuropathies, retinal degenerations, and corneal neuropathy, which contribute to the ever-increasing incidence of worldwide visual impairment. He has authored nearly 150 papers, chapters, commentaries, and critical reviews, reflecting his decades of rigorous investigations funded by dozens of extramural grants and awards from both federal and private-sector entities.
Research Keywords
Neurodegeneration, visual system, regenerative medicine, neuroprotection
Publications
Almaoui E, Calkins DJ, Wareham LK. Subclinical Corneal Neuropathy in Dry Eye Disease: A Driver of Ocular Surface Dysfunction?. Curr Eye Res [print-electronic]. 2026 May 5/4/2026; 1-12. PMID: 42080236, DOI: 10.1080/02713683.2026.2664593, ISSN: 1460-2202.
Holden JM, Calkins DJ. Potassium-dependent coupling of retinal astrocytes and Müller glia. Neural Regen Res [print-electronic]. 2026 Feb 2/28/2026; PMID: 41778710, PII: 01300535-990000000-01211, DOI: 10.4103/NRR.NRR-D-25-01563, ISSN: 1673-5374.
Clark KL, Mecca S, Almaoui E, Bossardet OL, Holden JM, Calkins DJ, Wareham LK. Pharmacological activation of cGMP signaling promotes astrocyte remodeling and enrichment of perivascular GLUT1 in the murine retina. Front Cell Neurosci. 2026; 20: 1870679. PMID: 42459923, PMCID: PMC13372325, DOI: 10.3389/fncel.2026.1870679, ISSN: 1662-5102.
Holden JM, Calkins DJ. Regional Position and Axonal Environment Shape Astrocyte Morphology in the Mouse Optic Projection. Mol Neurobiol. 2025 Nov 11/28/2025; 63(1): 202. PMID: 41315160, PMCID: PMC12662922, PII: 10.1007/s12035-025-05552-7, DOI: 10.1007/s12035-025-05552-7, ISSN: 1559-1182.
Wareham LK, Calkins DJ. Making tracks: microglia and the extracellular matrix. Mol Neurodegener. 2025 Sep 9/29/2025; 20(1): 101. PMID: 41024112, PMCID: PMC12481997, PII: 10.1186/s13024-025-00898-x, DOI: 10.1186/s13024-025-00898-x, ISSN: 1750-1326.
Holden JM, Boal AM, Wareham LK, Calkins DJ. Potassium-Dependent Coupling of Retinal Astrocyte Light Response to Müller Glia. Glia [print-electronic]. 2025 Jul; 73(7): 1520-34. PMID: 40264285, PMCID: PMC12121466, DOI: 10.1002/glia.70022, ISSN: 1098-1136.
Wareham LK, Ghanem GOB, Clark KL, Schlumpf E, Del Buono BJ, Calkins DJ. Topical Application of a Collagen Mimetic Peptide Restores Peripapillary Scleral Stiffness Reduced by Ocular Stress. Pharmaceuticals (Basel). 2025 Jun 6/12/2025; 18(6): PMID: 40573271, PMCID: PMC12196438, PII: ph18060875, DOI: 10.3390/ph18060875, ISSN: 1424-8247.
Holden JM, Calkins DJ. Bilateral astrocyte reaction to unilateral insult in the optic projection to the brain. Proc Natl Acad Sci U S A [print-electronic]. 2025 Apr 4/8/2025; 122(14): e2502602122. PMID: 40163738, PMCID: PMC12002340, DOI: 10.1073/pnas.2502602122, ISSN: 1091-6490.
Rex TS, Calkins DJ. Women in visual neural regeneration research. Neural Regen Res [print-electronic]. 2025 Feb 2/1/2025; 20(2): 489-90. PMID: 38819061, PMCID: PMC11317959, PII: 01300535-202502000-00026, DOI: 10.4103/NRR.NRR-D-24-00125, ISSN: 1673-5374.
Bossardet OL, Holden JM, Del Buono BJ, Schlumpf E, Wareham LK, Calkins DJ. Collagen mimetic peptides as novel therapeutics for vascular disease in the central nervous system. Front Neurosci. 2025; 19: 1569347. PMID: 40421131, PMCID: PMC12104236, DOI: 10.3389/fnins.2025.1569347, ISSN: 1662-4548.
Holden JM, Bossardet OL, Bou Ghanem G, Calkins DJ, Wareham LK. Chronic hyperglycemia alters retinal astrocyte microstructure and uptake of cholera toxin B in a murine model of diabetes. J Neurochem [print-electronic]. 2025 Jan; 169(1): e16237. PMID: 39374262, PMCID: PMC11658182, DOI: 10.1111/jnc.16237, ISSN: 1471-4159.
Cooper ML, Calkins DJ. Beyond hypertrophy: Changing views of astrocytes in glaucoma. Vision Res [print-electronic]. 2024 Oct; 223: 108461. PMID: 39059109, PII: S0042-6989(24)00105-6, DOI: 10.1016/j.visres.2024.108461, ISSN: 1878-5646.
Holden JM, Wareham LK, Calkins DJ. Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina. Glia [print-electronic]. 2024 Jul; 72(7): 1356-70. PMID: 38591270, PMCID: PMC11081821, DOI: 10.1002/glia.24536, ISSN: 1098-1136.
Bou Ghanem GO, Wareham LK, Calkins DJ. Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments. Prog Retin Eye Res [print-electronic]. 2024 May; 100: 101261. PMID: 38527623, PII: S1350-9462(24)00026-0, DOI: 10.1016/j.preteyeres.2024.101261, ISSN: 1873-1635.
Wareham LK, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target. Mol Neurodegener. 2024 Jan 1/25/2024; 19(1): 11. PMID: 38273335, PMCID: PMC10809576, PII: 10.1186/s13024-024-00704-0, DOI: 10.1186/s13024-024-00704-0, ISSN: 1750-1326.
Baratta RO, Schlumpf E, Del Buono BJ, DeLorey S, Ousler G, Calkins DJ. A Phase 2 Trial to Test Safety and Efficacy of ST-100, a Unique Collagen Mimetic Peptide Ophthalmic Solution for Dry Eye Disease. Ophthalmol Sci. 2024; 4(3): 100451. PMID: 38317866, PMCID: PMC10838901, PII: S2666-9145(23)00183-5, DOI: 10.1016/j.xops.2023.100451, ISSN: 2666-9145.
Bou Ghanem GO, Koktysh D, Baratta RO, Del Buono BJ, Schlumpf E, Wareham LK, Calkins DJ. Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head. Int J Mol Sci. 2023 Dec 12/1/2023; 24(23): PMID: 38069354, PMCID: PMC10707085, PII: ijms242317031, DOI: 10.3390/ijms242317031, ISSN: 1422-0067.
Risner ML, Ribeiro M, McGrady NR, Kagitapalli BS, Chamling X, Zack DJ, Calkins DJ. Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo. Cell Commun Signal. 2023 Oct 10/30/2023; 21(1): 305. PMID: 37904133, PMCID: PMC10614343, PII: 10.1186/s12964-023-01291-1, DOI: 10.1186/s12964-023-01291-1, ISSN: 1478-811X.
Naguib S, Backstrom JR, Artis E, Ghose P, Stahl A, Hardin R, Haider AA, Ang J, Calkins DJ, Rex TS. NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells. Acta Neuropathol Commun. 2023 Oct 10/24/2023; 11(1): 171. PMID: 37875948, PMCID: PMC10594672, PII: 10.1186/s40478-023-01663-1, DOI: 10.1186/s40478-023-01663-1, ISSN: 2051-5960.
McGrady NR, Boal AM, Risner ML, Taiel M, Sahel JA, Calkins DJ. Ocular stress enhances contralateral transfer of lenadogene nolparvovec gene therapy through astrocyte networks. Mol Ther [print-electronic]. 2023 Jul 7/5/2023; 31(7): 2005-13. PMID: 37016579, PMCID: PMC10362393, PII: S1525-0016(23)00195-8, DOI: 10.1016/j.ymthe.2023.03.035, ISSN: 1525-0024.
Johnson TV, Calkins DJ, Fortune B, Goldberg JL, La Torre A, Lamba DA, Meyer JS, Reh TA, Wallace VA, Zack DJ, Baranov P. The importance of unambiguous cell origin determination in neuronal repopulation studies. IScience. 2023 Apr 4/21/2023; 26(4): 106361. PMID: 37009209, PMCID: PMC10060674, PII: S2589-0042(23)00438-8, DOI: 10.1016/j.isci.2023.106361, ISSN: 2589-0042.
Boal AM, McGrady NR, Chamling X, Kagitapalli BS, Zack DJ, Calkins DJ, Risner ML. Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy. Transl Vis Sci Technol. 2023 Apr 4/3/2023; 12(4): 1. PMID: 37010860, PMCID: PMC10080917, PII: 2785496, DOI: 10.1167/tvst.12.4.1, ISSN: 2164-2591.
Naguib S, DeJulius CR, Backstrom JR, Haider AA, Ang JM, Boal AM, Calkins DJ, Duvall CL, Rex TS. Intraocular Sustained Release of EPO-R76E Mitigates Glaucoma Pathogenesis by Activating the NRF2/ARE Pathway. Antioxidants (Basel). 2023 Feb 2/23/2023; 12(3): PMID: 36978804, PMCID: PMC10045745, PII: antiox12030556, DOI: 10.3390/antiox12030556, ISSN: 2076-3921.
Holden JM, Wareham LK, Calkins DJ. Retinal astrocyte morphology predicts integration of vascular and neuronal architecture. Front Neurosci. 2023; 17: 1244679. PMID: 37621717, PMCID: PMC10445659, DOI: 10.3389/fnins.2023.1244679, ISSN: 1662-4548.
Wareham LK, Holden JM, Bossardet OL, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Collagen mimetic peptide repair of the corneal nerve bed in a mouse model of dry eye disease. Front Neurosci. 2023; 17: 1148950. PMID: 37260844, PMCID: PMC10228686, DOI: 10.3389/fnins.2023.1148950, ISSN: 1662-4548.
Boal AM, McGrady NR, Holden JM, Risner ML, Calkins DJ. Retinal ganglion cells adapt to ionic stress in experimental glaucoma. Front Neurosci. 2023; 17: 1142668. PMID: 37051140, PMCID: PMC10083336, DOI: 10.3389/fnins.2023.1142668, ISSN: 1662-4548.
Croteau LP, Risner ML, Wareham LK, McGrady NR, Chamling X, Zack DJ, Calkins DJ. Ex Vivo Integration of Human Stem Retinal Ganglion Cells into the Mouse Retina. Cells. 2022 Oct 10/15/2022; 11(20): PMID: 36291110, PMCID: PMC9600680, PII: cells11203241, DOI: 10.3390/cells11203241, ISSN: 2073-4409.
Newman NJ, Schniederjan M, Mendoza PR, Calkins DJ, Yu-Wai-Man P, Biousse V, Carelli V, Taiel M, Rugiero F, Singh P, Rogue A, Sahel JA, Ancian P. Absence of lenadogene nolparvovec DNA in a brain tumor biopsy from a patient in the REVERSE clinical study, a case report. BMC Neurol. 2022 Jul 7/12/2022; 22(1): 257. PMID: 35820885, PMCID: PMC9277876, PII: 10.1186/s12883-022-02787-y, DOI: 10.1186/s12883-022-02787-y, ISSN: 1471-2377.
Ribeiro M, Pasini S, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Collagen Mimetic Peptides Promote Adherence and Migration of ARPE-19 Cells While Reducing Inflammatory and Oxidative Stress. Int J Mol Sci. 2022 Jun 6/23/2022; 23(13): PMID: 35806007, PMCID: PMC9266392, PII: ijms23137004, DOI: 10.3390/ijms23137004, ISSN: 1422-0067.
Wareham LK, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, Goldberg JL, He Z, Duan X, Bu G, Davis AA, Shekhar K, Torre A, Chan DC, Canto-Soler MV, Flanagan JG, Subramanian P, Rossi S, Brunner T, Bovenkamp DE, Calkins DJ. Solving neurodegeneration: common mechanisms and strategies for new treatments. Mol Neurodegener. 2022 Mar 3/21/2022; 17(1): 23. PMID: 35313950, PMCID: PMC8935795, PII: 10.1186/s13024-022-00524-0, DOI: 10.1186/s13024-022-00524-0, ISSN: 1750-1326.
Holden JM, Al Hussein Al Awamlh S, Croteau LP, Boal AM, Rex TS, Risner ML, Calkins DJ, Wareham LK. Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice. Int J Mol Sci. 2022 Mar 3/12/2022; 23(6): PMID: 35328488, PMCID: PMC8954518, PII: ijms23063066, DOI: 10.3390/ijms23063066, ISSN: 1422-0067.
Ribeiro M, McGrady NR, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Intraocular Delivery of a Collagen Mimetic Peptide Repairs Retinal Ganglion Cell Axons in Chronic and Acute Injury Models. Int J Mol Sci. 2022 Mar 3/8/2022; 23(6): PMID: 35328332, PMCID: PMC8949359, PII: ijms23062911, DOI: 10.3390/ijms23062911, ISSN: 1422-0067.
Risner ML, Pasini S, McGrady NR, Calkins DJ. Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma. Mol Neurobiol [print-electronic]. 2022 Mar; 59(3): 1366-80. PMID: 34984584, PMCID: PMC8882107, PII: 10.1007/s12035-021-02675-5, DOI: 10.1007/s12035-021-02675-5, ISSN: 1559-1182.
McGrady NR, Holden JM, Ribeiro M, Boal AM, Risner ML, Calkins DJ. Axon hyperexcitability in the contralateral projection following unilateral optic nerve crush in mice. Brain Commun. 2022; 4(5): fcac251. PMID: 36267329, PMCID: PMC9576152, PII: fcac251, DOI: 10.1093/braincomms/fcac251, ISSN: 2632-1297.
Boal AM, McGrady NR, Risner ML, Calkins DJ. Sensitivity to extracellular potassium underlies type-intrinsic differences in retinal ganglion cell excitability. Front Cell Neurosci. 2022; 16: 966425. PMID: 35990894, PMCID: PMC9390602, DOI: 10.3389/fncel.2022.966425, ISSN: 1662-5102.
Baratta RO, Schlumpf E, Buono BJD, DeLorey S, Calkins DJ. Corneal collagen as a potential therapeutic target in dry eye disease. Surv Ophthalmol [print-electronic]. 2022; 67(1): 60-7. PMID: 33882269, PII: S0039-6257(21)00104-1, DOI: 10.1016/j.survophthal.2021.04.006, ISSN: 1879-3304.
Calkins DJ, Yu-Wai-Man P, Newman NJ, Taiel M, Singh P, Chalmey C, Rogue A, Carelli V, Ancian P, Sahel JA. Biodistribution of intravitreal lenadogene nolparvovec gene therapy in nonhuman primates. Mol Ther Methods Clin Dev. 2021 Dec 12/10/2021; 23: 307-18. PMID: 34729378, PMCID: PMC8526752, PII: S2329-0501(21)00151-0, DOI: 10.1016/j.omtm.2021.09.013, ISSN: 2329-0501.
Calkins DJ. Adaptive responses to neurodegenerative stress in glaucoma. Prog Retin Eye Res [print-electronic]. 2021 Sep; 84: 100953. PMID: 33640464, PMCID: PMC8384979, PII: S1350-9462(21)00014-8, DOI: 10.1016/j.preteyeres.2021.100953, ISSN: 1873-1635.
Risner ML, Pasini S, Chamling X, McGrady NR, Goldberg JL, Zack DJ, Calkins DJ. Intrinsic Morphologic and Physiologic Development of Human Derived Retinal Ganglion Cells In Vitro. Transl Vis Sci Technol. 2021 Aug 8/12/2021; 10(10): 1. PMID: 34383881, PMCID: PMC8362626, PII: 2776589, DOI: 10.1167/tvst.10.10.1, ISSN: 2164-2591.
Risner ML, Pasini S, McGrady NR, D'Alessandro KB, Yao V, Cooper ML, Calkins DJ. Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma. Mol Neurodegener. 2021 Jun 6/5/2021; 16(1): 36. PMID: 34090501, PMCID: PMC8180099, PII: 10.1186/s13024-021-00459-y, DOI: 10.1186/s13024-021-00459-y, ISSN: 1750-1326.
Boal AM, Risner ML, Cooper ML, Wareham LK, Calkins DJ. Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. Cells. 2021 Jun 6/2/2021; 10(6): PMID: 34199470, PMCID: PMC8228804, PII: cells10061368, DOI: 10.3390/cells10061368, ISSN: 2073-4409.
Naguib S, Backstrom JR, Gil M, Calkins DJ, Rex TS. Retinal oxidative stress activates the NRF2/ARE pathway: An early endogenous protective response to ocular hypertension. Redox Biol [print-electronic]. 2021 Jun; 42: 101883. PMID: 33579667, PMCID: PMC8113046, PII: S2213-2317(21)00031-8, DOI: 10.1016/j.redox.2021.101883, ISSN: 2213-2317.
Al Hussein Al Awamlh S, Wareham LK, Risner ML, Calkins DJ. Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration. Int J Mol Sci. 2021 Apr 4/28/2021; 22(9): PMID: 33925119, PMCID: PMC8124776, PII: ijms22094672, DOI: 10.3390/ijms22094672, ISSN: 1422-0067.
McGrady NR, Pasini S, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Restoring the Extracellular Matrix: A Neuroprotective Role for Collagen Mimetic Peptides in Experimental Glaucoma. Front Pharmacol. 2021; 12: 764709. PMID: 34795592, PMCID: PMC8592892, PII: 764709, DOI: 10.3389/fphar.2021.764709, ISSN: 1663-9812.
Baratta RO, Del Buono BJ, Schlumpf E, Ceresa BP, Calkins DJ. Collagen Mimetic Peptides Promote Corneal Epithelial Cell Regeneration. Front Pharmacol. 2021; 12: 705623. PMID: 34483909, PMCID: PMC8415399, PII: 705623, DOI: 10.3389/fphar.2021.705623, ISSN: 1663-9812.
Yu-Wai-Man P, Newman NJ, Carelli V, Moster ML, Biousse V, Sadun AA, Klopstock T, Vignal-Clermont C, Sergott RC, Rudolph G, La Morgia C, Karanjia R, Taiel M, Blouin L, Burguière P, Smits G, Chevalier C, Masonson H, Salermo Y, Katz B, Picaud S, Calkins DJ, Sahel JA. Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy. Sci Transl Med. 2020 Dec 12/9/2020; 12(573): PMID: 33298565, PII: 12/573/eaaz7423, DOI: 10.1126/scitranslmed.aaz7423, ISSN: 1946-6242.
Cooper ML, Pasini S, Lambert WS, D'Alessandro KB, Yao V, Risner ML, Calkins DJ. Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress. Proc Natl Acad Sci U S A [print-electronic]. 2020 Aug 8/4/2020; 117(31): 18810-21. PMID: 32690710, PMCID: PMC7414143, PII: 2009425117, DOI: 10.1073/pnas.2009425117, ISSN: 1091-6490.
Lambert WS, Pasini S, Collyer JW, Formichella CR, Ghose P, Carlson BJ, Calkins DJ. Of Mice and Monkeys: Neuroprotective Efficacy of the p38 Inhibitor BIRB 796 Depends on Model Duration in Experimental Glaucoma. Sci Rep. 2020 May 5/22/2020; 10(1): 8535. PMID: 32444682, PMCID: PMC7244559, PII: 10.1038/s41598-020-65374-6, DOI: 10.1038/s41598-020-65374-6, ISSN: 2045-2322.
Risner ML, McGrady NR, Boal AM, Pasini S, Calkins DJ. TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress. Front Cell Neurosci. 2020; 14: 603419. PMID: 33505248, PMCID: PMC7829306, DOI: 10.3389/fncel.2020.603419, ISSN: 1662-5102.
Wareham LK, Risner ML, Calkins DJ. Protect, Repair, and Regenerate: Towards Restoring Vision in Glaucoma. Curr Ophthalmol Rep [print-electronic]. 2020; 8(4): 301-10. PMID: 33269115, PMCID: PMC7686214, PII: 259, DOI: 10.1007/s40135-020-00259-5, ISSN: 2167-4868.
Wareham LK, Calkins DJ. The Neurovascular Unit in Glaucomatous Neurodegeneration. Front Cell Dev Biol. 2020; 8: 452. PMID: 32656207, PMCID: PMC7325980, DOI: 10.3389/fcell.2020.00452, ISSN: 2296-634X.
McGrady NR, Risner ML, Vest V, Calkins DJ. TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma. Front Physiol. 2020; 11: 249. PMID: 32273850, PMCID: PMC7113399, DOI: 10.3389/fphys.2020.00249, ISSN: 1664-042X.
Risner ML, McGrady NR, Pasini S, Lambert WS, Calkins DJ. Elevated ocular pressure reduces voltage-gated sodium channel NaV1.2 protein expression in retinal ganglion cell axons. Exp Eye Res [print-electronic]. 2020 Jan; 190: 107873. PMID: 31734278, PMCID: PMC6957720, PII: S0014-4835(19)30587-1, DOI: 10.1016/j.exer.2019.107873, ISSN: 1096-0007.
Kubota R, Calkins DJ, Henry SH, Linsenmeier RA. Emixustat Reduces Metabolic Demand of Dark Activity in the Retina. Invest Ophthalmol Vis Sci. 2019 Nov 11/1/2019; 60(14): 4924-30. PMID: 31770432, PII: 2756154, DOI: 10.1167/iovs.19-28194, ISSN: 1552-5783.
Lambert WS, Carlson BJ, Ghose P, Vest VD, Yao V, Calkins DJ. Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate. Sci Rep. 2019 Aug 8/9/2019; 9(1): 11572. PMID: 31399621, PMCID: PMC6689098, PII: 10.1038/s41598-019-48054-y, DOI: 10.1038/s41598-019-48054-y, ISSN: 2045-2322.
Bernardo-Colón A, Vest V, Cooper ML, Naguib SA, Calkins DJ, Rex TS. Progression and Pathology of Traumatic Optic Neuropathy From Repeated Primary Blast Exposure. Front Neurosci. 2019; 13: 719. PMID: 31354422, PMCID: PMC6637732, DOI: 10.3389/fnins.2019.00719, ISSN: 1662-4548.
Bernardo-Colón A, Vest V, Clark A, Cooper ML, Calkins DJ, Harrison FE, Rex TS. Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Cell Death Dis. 2018 Oct 10/26/2018; 9(11): 1097. PMID: 30367086, PMCID: PMC6203845, PII: 10.1038/s41419-018-1061-4, DOI: 10.1038/s41419-018-1061-4, ISSN: 2041-4889.
Laughter MR, Bardill JR, Ammar DA, Pena B, Calkins DJ, Park D. Injectable Neurotrophic Factor Delivery System Supporting Retinal Ganglion Cell Survival and Regeneration Following Optic Nerve Crush. ACS Biomater Sci Eng [print-electronic]. 2018 Sep 9/10/2018; 4(9): 3374-83. PMID: 31431919, PMCID: PMC6701853, DOI: 10.1021/acsbiomaterials.8b00803, ISSN: 2373-9878.
Cooper ML, Collyer JW, Calkins DJ. Astrocyte remodeling without gliosis precedes optic nerve Axonopathy. Acta Neuropathol Commun. 2018 May 5/10/2018; 6(1): 38. PMID: 29747701, PMCID: PMC5946396, PII: 10.1186/s40478-018-0542-0, DOI: 10.1186/s40478-018-0542-0, ISSN: 2051-5960.
Risner ML, Pasini S, Cooper ML, Lambert WS, Calkins DJ. Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2018 Mar 3/6/2018; 115(10): E2393-E2402. PMID: 29463759, PII: 1714888115, DOI: 10.1073/pnas.1714888115, ISSN: 1091-6490.
Risner ML, Pasini S, Cooper ML, Lambert WS, Calkins DJ. Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2018 Mar 3/6/2018; 115(10): E2393-E2402. PMID: 29463759, PII: 1714888115, DOI: 10.1073/pnas.1714888115, ISSN: 1091-6490.
Calkins DJ, Lambert WS, Formichella CR, McLaughlin WM, Sappington RM. The Microbead Occlusion Model of Ocular Hypertension in Mice. Methods Mol. Biol. 2018; 1695: 23-39. PMID: 29190015, DOI: 10.1007/978-1-4939-7407-8_3, ISSN: 1940-6029.
Calkins DJ, Lambert WS, Formichella CR, McLaughlin WM, Sappington RM. The Microbead Occlusion Model of Ocular Hypertension in Mice. Methods Mol. Biol. 2018; 1695: 23-39. PMID: 29190015, DOI: 10.1007/978-1-4939-7407-8_3, ISSN: 1940-6029.
Calkins DJ, Sternberg P. The Solar Eclipse of 2017-A (Protected) View From the Path of Totality. JAMA Ophthalmol. 2017 Sep 9/1/2017; 135(9): 907-8. PMID: 28820916, PII: 2648904, DOI: 10.1001/jamaophthalmol.2017.2936, ISSN: 2168-6173.
Calkins DJ, Sternberg P. The Solar Eclipse of 2017-A (Protected) View From the Path of Totality. JAMA Ophthalmol. 2017 Sep 9/1/2017; 135(9): 907-8. PMID: 28820916, PII: 2648904, DOI: 10.1001/jamaophthalmol.2017.2936, ISSN: 2168-6173.
Calkins DJ, Pekny M, Cooper ML, Benowitz L, . The challenge of regenerative therapies for the optic nerve in glaucoma. Exp. Eye Res [print-electronic]. 2017 Apr; 157: 28-33. PMID: 28153739, PII: S0014-4835(17)30069-6, DOI: 10.1016/j.exer.2017.01.007, ISSN: 1096-0007.
Calkins DJ, Pekny M, Cooper ML, Benowitz L, . The challenge of regenerative therapies for the optic nerve in glaucoma. Exp. Eye Res [print-electronic]. 2017 Apr; 157: 28-33. PMID: 28153739, PII: S0014-4835(17)30069-6, DOI: 10.1016/j.exer.2017.01.007, ISSN: 1096-0007.
Anderson DMG, Lambert W, Calkins DJ, Ablonczy Z, Crouch RK, Caprioli RM, Schey KL. Imaging MS of Rodent Ocular Tissues and the Optic Nerve. Methods Mol. Biol. 2017; 1618: 15-27. PMID: 28523496, DOI: 10.1007/978-1-4939-7051-3_3, ISSN: 1940-6029.
Lambert WS, Carlson BJ, Formichella CR, Sappington RM, Ahlem C, Calkins DJ. Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma. Front Neurosci. 2017; 11: 45. PMID: 28223915, PMCID: PMC5293777, DOI: 10.3389/fnins.2017.00045, ISSN: 1662-4548.
Lambert WS, Carlson BJ, Formichella CR, Sappington RM, Ahlem C, Calkins DJ. Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma. Front Neurosci. 2017; 11: 45. PMID: 28223915, PMCID: PMC5293777, DOI: 10.3389/fnins.2017.00045, ISSN: 1662-4548.
Anderson DMG, Lambert W, Calkins DJ, Ablonczy Z, Crouch RK, Caprioli RM, Schey KL. Imaging MS of Rodent Ocular Tissues and the Optic Nerve. Methods Mol. Biol. 2017; 1618: 15-27. PMID: 28523496, DOI: 10.1007/978-1-4939-7051-3_3, ISSN: 1940-6029.
Bosco A, Breen KT, Anderson SR, Steele MR, Calkins DJ, Vetter ML. Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. Exp. Eye Res [print-electronic]. 2016 Sep; 150: 34-43. PMID: 26851485, PMCID: PMC4972706, PII: S0014-4835(16)30013-6, DOI: 10.1016/j.exer.2016.01.014, ISSN: 1096-0007.
Cooper ML, Crish SD, Inman DM, Horner PJ, Calkins DJ. Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Exp. Eye Res [print-electronic]. 2016 Sep; 150: 22-33. PMID: 26646560, PMCID: PMC4889569, PII: S0014-4835(15)30074-9, DOI: 10.1016/j.exer.2015.11.016, ISSN: 1096-0007.
Bosco A, Breen KT, Anderson SR, Steele MR, Calkins DJ, Vetter ML. Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. Exp. Eye Res [print-electronic]. 2016 Sep; 150: 34-43. PMID: 26851485, PMCID: PMC4972706, PII: S0014-4835(16)30013-6, DOI: 10.1016/j.exer.2016.01.014, ISSN: 1096-0007.
Cooper ML, Crish SD, Inman DM, Horner PJ, Calkins DJ. Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Exp. Eye Res [print-electronic]. 2016 Sep; 150: 22-33. PMID: 26646560, PMCID: PMC4889569, PII: S0014-4835(15)30074-9, DOI: 10.1016/j.exer.2015.11.016, ISSN: 1096-0007.
Breen KT, Anderson SR, Steele MR, Calkins DJ, Bosco A, Vetter ML. Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma. Front Neurosci. 2016; 10: 526. PMID: 27932942, PMCID: PMC5123443, DOI: 10.3389/fnins.2016.00526, ISSN: 1662-4548.
Breen KT, Anderson SR, Steele MR, Calkins DJ, Bosco A, Vetter ML. Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma. Front Neurosci. 2016; 10: 526. PMID: 27932942, PMCID: PMC5123443, DOI: 10.3389/fnins.2016.00526, ISSN: 1662-4548.
Bond WS, Hines-Beard J, GoldenMerry YL, Davis M, Farooque A, Sappington RM, Calkins DJ, Rex TS. Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma. Mol. Ther [print-electronic]. 2015 Oct 10/27/2015; PMID: 26502777, PII: mt2015198, DOI: 10.1038/mt.2015.198, ISSN: 1525-0024.
Crish SD, Calkins DJ. Central visual pathways in glaucoma: evidence for distal mechanisms of neuronal self-repair. J Neuroophthalmol. 2015 Sep; 35 Suppl 1: S29-37. PMID: 26274834, PII: 00041327-201509001-00005, DOI: 10.1097/WNO.0000000000000291, ISSN: 1536-5166.
Lambert WS, Carlson BJ, van der Ende AE, Shih G, Dobish JN, Calkins DJ, Harth E. Nanosponge-Mediated Drug Delivery Lowers Intraocular Pressure. Transl Vis Sci Technol. 2015 Jan; 4(1): 1. PMID: 25599009, PMCID: PMC4294067, DOI: 10.1167/tvst.4.1.1, ISSN: 2164-2591.
Sappington RM, Sidorova T, Ward NJ, Chakravarthy R, Ho KW, Calkins DJ. Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress. Channels (Austin). 2015; 9(2): 102-13. PMID: 25713995, PMCID: PMC4594535, DOI: 10.1080/19336950.2015.1009272, ISSN: 1933-6969.
Weitlauf C, Ward NJ, Lambert WS, Sidorova TN, Ho KW, Sappington RM, Calkins DJ. Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation. J. Neurosci. 2014 Nov 11/12/2014; 34(46): 15369-81. PMID: 25392504, PMCID: PMC4228139, PII: 34/46/15369, DOI: 10.1523/JNEUROSCI.3424-14.2014, ISSN: 1529-2401.
Ho KW, Lambert WS, Calkins DJ. Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration. Glia [print-electronic]. 2014 Sep; 62(9): 1435-51. PMID: 24838827, PMCID: PMC4107153, DOI: 10.1002/glia.22691, ISSN: 1098-1136.
Ward NJ, Ho KW, Lambert WS, Weitlauf C, Calkins DJ. Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection. J. Neurosci. 2014 Feb 2/26/2014; 34(9): 3161-70. PMID: 24573275, PMCID: PMC3935081, PII: 34/9/3161, DOI: 10.1523/JNEUROSCI.4089-13.2014, ISSN: 1529-2401.
Calkins DJ. Age-related changes in the visual pathways: blame it on the axon. Invest. Ophthalmol. Vis. Sci. 2013 Dec; 54(14): ORSF37-41. PMID: 24335066, PMCID: PMC3864377, PII: 54/14/ORSF37, DOI: 10.1167/iovs.13-12784, ISSN: 1552-5783.
Dapper JD, Crish SD, Pang IH, Calkins DJ. Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy. Neurobiol. Dis [print-electronic]. 2013 Nov; 59: 26-37. PMID: 23859799, PMCID: PMC3775981, PII: S0969-9961(13)00195-2, DOI: 10.1016/j.nbd.2013.07.001, ISSN: 1095-953X.
Crish SD, Dapper JD, MacNamee SE, Balaram P, Sidorova TN, Lambert WS, Calkins DJ. Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target. Neuroscience [print-electronic]. 2013 Jan 1/15/2013; 229: 55-70. PMID: 23159315, PMCID: PMC3534890, PII: S0306-4522(12)01098-6, DOI: 10.1016/j.neuroscience.2012.10.069, ISSN: 1873-7544.
Anderson DM, Mills D, Spraggins J, Lambert WS, Calkins DJ, Schey KL. High-resolution matrix-assisted laser desorption ionization-imaging mass spectrometry of lipids in rodent optic nerve tissue. Mol. Vis [print-electronic]. 2013; 19: 581-92. PMID: 23559852, PMCID: PMC3611942, ISSN: 1090-0535.
Calkins DJ. Critical pathogenic events underlying progression of neurodegeneration in glaucoma. Prog Retin Eye Res [print-electronic]. 2012 Nov; 31(6): 702-19. PMID: 22871543, PMCID: PMC3472111, PII: S1350-9462(12)00053-5, DOI: 10.1016/j.preteyeres.2012.07.001, ISSN: 1873-1635.
Calkins DJ, Horner PJ. The cell and molecular biology of glaucoma: axonopathy and the brain. Invest. Ophthalmol. Vis. Sci. 2012 May; 53(5): 2482-4. PMID: 22562846, PMCID: PMC3998097, PII: 53/5/2482, DOI: 10.1167/iovs.12-9483i, ISSN: 1552-5783.
Shih GC, Calkins DJ. Secondary neuroprotective effects of hypotensive drugs and potential mechanisms of action. Expert Rev Ophthalmol. 2012 Apr; 7(2): 161-75. PMID: 22737176, PMCID: PMC3379897, DOI: 10.1586/eop.12.13, ISSN: 1746-9899.
Ho KW, Ward NJ, Calkins DJ. TRPV1: a stress response protein in the central nervous system. Am J Neurodegener Dis [print-electronic]. 2012; 1(1): 1-14. PMID: 22737633, PMCID: PMC3560445, ISSN: 2165-591X.
Crish SD, Calkins DJ. Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms. Neuroscience [print-electronic]. 2011 Mar 3/10/2011; 176: 1-11. PMID: 21187126, PMCID: PMC3040267, PII: S0306-4522(10)01641-6, DOI: 10.1016/j.neuroscience.2010.12.036, ISSN: 1873-7544.
Lambert WS, Ruiz L, Crish SD, Wheeler LA, Calkins DJ. Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons. Mol Neurodegener. 2011; 6(1): 4. PMID: 21232114, PMCID: PMC3035592, PII: 1750-1326-6-4, DOI: 10.1186/1750-1326-6-4, ISSN: 1750-1326.
Chen H, Wei X, Cho KS, Chen G, Sappington R, Calkins DJ, Chen DF. Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse. Invest. Ophthalmol. Vis. Sci. 2011 Jan; 52(1): 36-44. PMID: 20702815, PMCID: PMC3053285, PII: iovs.09-5115, DOI: 10.1167/iovs.09-5115, ISSN: 1552-5783.
Baltan S, Inman DM, Danilov CA, Morrison RS, Calkins DJ, Horner PJ. Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. J. Neurosci. 2010 Apr 4/21/2010; 30(16): 5644-52. PMID: 20410117, PMCID: PMC2884009, PII: 30/16/5644, DOI: 10.1523/JNEUROSCI.5956-09.2010, ISSN: 1529-2401.
Crish SD, Sappington RM, Inman DM, Horner PJ, Calkins DJ. Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Mar 3/16/2010; 107(11): 5196-201. PMID: 20194762, PMCID: PMC2841892, PII: 0913141107, DOI: 10.1073/pnas.0913141107, ISSN: 1091-6490.
Sappington RM, Carlson BJ, Crish SD, Calkins DJ. The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Jan; 51(1): 207-16. PMID: 19850836, PMCID: PMC2869054, PII: iovs.09-3947, DOI: 10.1167/iovs.09-3947, ISSN: 1552-5783.
Sappington RM, Sidorova T, Long DJ, Calkins DJ. TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2009 Feb; 50(2): 717-28. PMID: 18952924, PMCID: PMC3549616, PII: iovs.08-2321, DOI: 10.1167/iovs.08-2321, ISSN: 1552-5783.
Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, Sappington RM, Calkins DJ. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J. Neurosci. 2008 Nov 11/12/2008; 28(46): 12085-96. PMID: 19005073, PMCID: PMC2683273, PII: 28/46/12085, DOI: 10.1523/JNEUROSCI.3200-08.2008, ISSN: 1529-2401.
Calkins DJ, Horner PJ, Roberts R, Gradianu M, Berkowitz BA. Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2008 Nov; 49(11): 5083-8. PMID: 18552381, PMCID: PMC2586056, PII: iovs.08-2205, DOI: 10.1167/iovs.08-2205, ISSN: 1552-5783.
Sappington RM, Calkins DJ. Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2008 Jul; 49(7): 3004-17. PMID: 18362111, PMCID: PMC4139938, PII: iovs.07-1355, DOI: 10.1167/iovs.07-1355, ISSN: 1552-5783.
Bosco A, Inman DM, Steele MR, Wu G, Soto I, Marsh-Armstrong N, Hubbard WC, Calkins DJ, Horner PJ, Vetter ML. Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2008 Apr; 49(4): 1437-46. PMID: 18385061, PII: 49/4/1437, DOI: 10.1167/iovs.07-1337, ISSN: 0146-0404.
Buckingham BP, Inman DM, Lambert W, Oglesby E, Calkins DJ, Steele MR, Vetter ML, Marsh-Armstrong N, Horner PJ. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J. Neurosci. 2008 Mar 3/12/2008; 28(11): 2735-44. PMID: 18337403, PII: 28/11/2735, DOI: 10.1523/JNEUROSCI.4443-07.2008, ISSN: 1529-2401.
Calkins, D.J.. A Neurological Perspective of Glaucoma. Glaucoma Today. 2008; ((September/October)): 18-20.
Berkowitz BA, Roberts R, Luan H, Bissig D, Bui BV, Gradianu M, Calkins DJ, Vingrys AJ. Manganese-enhanced MRI studies of alterations of intraretinal ion demand in models of ocular injury. Invest. Ophthalmol. Vis. Sci. 2007 Aug; 48(8): 3796-804. PMID: 17652754, PMCID: PMC2041849, PII: 48/8/3796, DOI: 10.1167/iovs.06-1278, ISSN: 0146-0404.
Calkins DJ, Sterling P. Microcircuitry for two types of achromatic ganglion cell in primate fovea. J. Neurosci. 2007 Mar 3/7/2007; 27(10): 2646-53. PMID: 17344402, PII: 27/10/2646, DOI: 10.1523/JNEUROSCI.4739-06.2007, ISSN: 1529-2401.
Hanna MC, Calkins DJ. Expression of genes encoding glutamate receptors and transporters in rod and cone bipolar cells of the primate retina determined by single-cell polymerase chain reaction. Mol. Vis. 2007; 13: 2194-208. PMID: 18087239, PII: v13/a249, ISSN: 1090-0535.
Sappington RM, Calkins DJ. Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin/proteasome pathway and NFkappaB. Invest. Ophthalmol. Vis. Sci. 2006 Sep; 47(9): 3860-9. PMID: 16936098, PII: 47/9/3860, DOI: 10.1167/iovs.05-1408, ISSN: 0146-0404.
DiLoreto DA, Luo C, Calkins DJ, del Cerro M. An ultrastructural study of the pathology of the retinal pigment epithelium, Bruch's membrane, and the choriocapillaris in the aged Fischer 344 rat. Curr. Eye Res. 2006 Sep; 31(9): 749-63. PMID: 16966148, PII: J762R60681856480, DOI: 10.1080/02713680600864782, ISSN: 0271-3683.
Sappington RM, Chan M, Calkins DJ. Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest. Ophthalmol. Vis. Sci. 2006 Jul; 47(7): 2932-42. PMID: 16799036, PII: 47/7/2932, DOI: 10.1167/iovs.05-1407, ISSN: 0146-0404.
Inman DM, Sappington RM, Horner PJ, Calkins DJ. Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2006 Mar; 47(3): 986-96. PMID: 16505033, PII: 47/3/986, DOI: 10.1167/iovs.05-0925, ISSN: 0146-0404.
Steele MR, Inman DM, Calkins DJ, Horner PJ, Vetter ML. Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2006 Mar; 47(3): 977-85. PMID: 16505032, PII: 47/3/977, DOI: 10.1167/iovs.05-0865, ISSN: 0146-0404.
Hanna MC, Calkins DJ. Expression and sequences of genes encoding glutamate receptors and transporters in primate retina determined using 3'-end amplification polymerase chain reaction. Mol. Vis. 2006; 12: 961-76. PMID: 16943768, PII: v12/a108, ISSN: 1090-0535.
Calkins DJ. Localization of ionotropic glutamate receptors to invaginating dendrites at the cone synapse in primate retina. Vis. Neurosci. 2005 Jul; 22(4): 469-77. PMID: 16212704, PII: S0952523805224082, DOI: 10.1017/S0952523805224082, ISSN: 0952-5238.
Calkins DJ. Remembering Bob Rodieck: 1937-2003. Vis. Neurosci. 2005 Jul; 22(4): 379-81. PMID: 16212696, PII: S0952523805224136, DOI: 10.1017/S0952523805224136, ISSN: 0952-5238.
Wilson JD, Bigelow CE, Calkins DJ, Foster TH. Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling. Biophys. J [print-electronic]. 2005 Apr; 88(4): 2929-38. PMID: 15653724, PMCID: PMC1305387, PII: S0006-3495(05)73345-2, DOI: 10.1529/biophysj.104.054528, ISSN: 0006-3495.
Calkins DJ, Sappington RM, Hendry SH. Morphological identification of ganglion cells expressing the alpha subunit of type II calmodulin-dependent protein kinase in the macaque retina. J. Comp. Neurol. 2005 Jan 1/10/2005; 481(2): 194-209. PMID: 15562509, DOI: 10.1002/cne.20368, ISSN: 0021-9967.
Calkins, DJ. [place unknown: publisher unknown]; 2004.
Sappington RM, Pearce DA, Calkins DJ. Optic nerve degeneration in a murine model of juvenile ceroid lipofuscinosis. Invest. Ophthalmol. Vis. Sci. 2003 Sep; 44(9): 3725-31. PMID: 12939285, ISSN: 0146-0404.
Pasternak, Tatiana; Bisley, James; Calkins, David J.. Visual processing in the primate brain. In Handbook of Psychology, Volume 3, Biological Psychology (M. Gallagher & R. Nelson, ed.), John Wiley and Sons. [place unknown: publisher unknown]; 2003.
Harvey DM, Calkins DJ. Localization of kainate receptors to the presynaptic active zone of the rod photoreceptor in primate retina. Vis. Neurosci. 2002 Sep; 19(5): 681-92. PMID: 12507334, PII: S0952523802195137, ISSN: 0952-5238.
Yao PJ, Coleman PD, Calkins DJ. High-resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons. J. Comp. Neurol. 2002 May 5/27/2002; 447(2): 152-62. PMID: 11977118, DOI: 10.1002/cne.10217, ISSN: 0021-9967.
Calkins DJ. Seeing with S cones. Prog Retin Eye Res. 2001 May; 20(3): 255-87. PMID: 11286894, PII: S1350-9462(00)00026-4, ISSN: 1350-9462.
Calkins DJ. Representation of cone signals in the primate retina. J Opt Soc Am A Opt Image Sci Vis. 2000 Mar; 17(3): 597-606. PMID: 10708041, ISSN: 1084-7529.
Calkins DJ, Sterling P. Evidence that circuits for spatial and color vision segregate at the first retinal synapse. Neuron. 1999 Oct; 24(2): 313-21. PMID: 10571226, PII: S0896-6273(00)80846-6, ISSN: 0896-6273.
Calkins, David J.. Synaptic organization of cone pathways in the primate retina. In Color Vision: from Molecular Genetics to Perception (K. Gegenfurtner & L. Sharpe, eds.), Cambridge University Press. 1999.
Hendry SH, Calkins DJ. Neuronal chemistry and functional organization in the primate visual system. Trends Neurosci. 1998 Aug; 21(8): 344-9. PMID: 9720602, PII: S0166-2236(98)01245-4, ISSN: 0166-2236.
Calkins DJ, Tsukamoto Y, Sterling P.. Microcircuitry and mosaic of a blue-yellow ganglion cell in the primate retina. J Neurosci. 1998; 18((9)): 3373-85.
Calkins DJ, Tsukamoto Y, Sterling P. Foveal cones form basal as well as invaginating junctions with diffuse ON bipolar cells. Vision Res. 1996 Nov; 36(21): 3373-81. PMID: 8977004, PII: 0042-6989(95)00333-9, ISSN: 0042-6989.
Calkins DJ, Sterling P. Absence of spectrally specific lateral inputs to midget ganglion cells in primate retina. Nature. 1996 Jun 6/13/1996; 381(6583): 613-5. PMID: 8637598, DOI: 10.1038/381613a0, ISSN: 0028-0836.
Calkins DJ, Schein SJ, Tsukamoto Y, Sterling P. M and L cones in macaque fovea connect to midget ganglion cells by different numbers of excitatory synapses. Nature. 1994 Sep 9/1/1994; 371(6492): 70-2. PMID: 8072528, DOI: 10.1038/371070a0, ISSN: 0028-0836.
Calkins DJ, Thornton JE, Pugh EN. Monochromatism determined at a long-wavelength/middle-wavelength cone-antagonistic locus. Vision Res. 1992 Dec; 32(12): 2349-67. PMID: 1288011, PII: 0042-6989(92)90098-4, ISSN: 0042-6989.
Holden JM, Calkins DJ. Potassium-dependent coupling of retinal astrocytes and Müller glia. Neural Regen Res [print-electronic]. 2026 Feb 2/28/2026; PMID: 41778710, PII: 01300535-990000000-01211, DOI: 10.4103/NRR.NRR-D-25-01563, ISSN: 1673-5374.
Clark KL, Mecca S, Almaoui E, Bossardet OL, Holden JM, Calkins DJ, Wareham LK. Pharmacological activation of cGMP signaling promotes astrocyte remodeling and enrichment of perivascular GLUT1 in the murine retina. Front Cell Neurosci. 2026; 20: 1870679. PMID: 42459923, PMCID: PMC13372325, DOI: 10.3389/fncel.2026.1870679, ISSN: 1662-5102.
Holden JM, Calkins DJ. Regional Position and Axonal Environment Shape Astrocyte Morphology in the Mouse Optic Projection. Mol Neurobiol. 2025 Nov 11/28/2025; 63(1): 202. PMID: 41315160, PMCID: PMC12662922, PII: 10.1007/s12035-025-05552-7, DOI: 10.1007/s12035-025-05552-7, ISSN: 1559-1182.
Wareham LK, Calkins DJ. Making tracks: microglia and the extracellular matrix. Mol Neurodegener. 2025 Sep 9/29/2025; 20(1): 101. PMID: 41024112, PMCID: PMC12481997, PII: 10.1186/s13024-025-00898-x, DOI: 10.1186/s13024-025-00898-x, ISSN: 1750-1326.
Holden JM, Boal AM, Wareham LK, Calkins DJ. Potassium-Dependent Coupling of Retinal Astrocyte Light Response to Müller Glia. Glia [print-electronic]. 2025 Jul; 73(7): 1520-34. PMID: 40264285, PMCID: PMC12121466, DOI: 10.1002/glia.70022, ISSN: 1098-1136.
Wareham LK, Ghanem GOB, Clark KL, Schlumpf E, Del Buono BJ, Calkins DJ. Topical Application of a Collagen Mimetic Peptide Restores Peripapillary Scleral Stiffness Reduced by Ocular Stress. Pharmaceuticals (Basel). 2025 Jun 6/12/2025; 18(6): PMID: 40573271, PMCID: PMC12196438, PII: ph18060875, DOI: 10.3390/ph18060875, ISSN: 1424-8247.
Holden JM, Calkins DJ. Bilateral astrocyte reaction to unilateral insult in the optic projection to the brain. Proc Natl Acad Sci U S A [print-electronic]. 2025 Apr 4/8/2025; 122(14): e2502602122. PMID: 40163738, PMCID: PMC12002340, DOI: 10.1073/pnas.2502602122, ISSN: 1091-6490.
Rex TS, Calkins DJ. Women in visual neural regeneration research. Neural Regen Res [print-electronic]. 2025 Feb 2/1/2025; 20(2): 489-90. PMID: 38819061, PMCID: PMC11317959, PII: 01300535-202502000-00026, DOI: 10.4103/NRR.NRR-D-24-00125, ISSN: 1673-5374.
Bossardet OL, Holden JM, Del Buono BJ, Schlumpf E, Wareham LK, Calkins DJ. Collagen mimetic peptides as novel therapeutics for vascular disease in the central nervous system. Front Neurosci. 2025; 19: 1569347. PMID: 40421131, PMCID: PMC12104236, DOI: 10.3389/fnins.2025.1569347, ISSN: 1662-4548.
Holden JM, Bossardet OL, Bou Ghanem G, Calkins DJ, Wareham LK. Chronic hyperglycemia alters retinal astrocyte microstructure and uptake of cholera toxin B in a murine model of diabetes. J Neurochem [print-electronic]. 2025 Jan; 169(1): e16237. PMID: 39374262, PMCID: PMC11658182, DOI: 10.1111/jnc.16237, ISSN: 1471-4159.
Cooper ML, Calkins DJ. Beyond hypertrophy: Changing views of astrocytes in glaucoma. Vision Res [print-electronic]. 2024 Oct; 223: 108461. PMID: 39059109, PII: S0042-6989(24)00105-6, DOI: 10.1016/j.visres.2024.108461, ISSN: 1878-5646.
Holden JM, Wareham LK, Calkins DJ. Morphological and electrophysiological characterization of a novel displaced astrocyte in the mouse retina. Glia [print-electronic]. 2024 Jul; 72(7): 1356-70. PMID: 38591270, PMCID: PMC11081821, DOI: 10.1002/glia.24536, ISSN: 1098-1136.
Bou Ghanem GO, Wareham LK, Calkins DJ. Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments. Prog Retin Eye Res [print-electronic]. 2024 May; 100: 101261. PMID: 38527623, PII: S1350-9462(24)00026-0, DOI: 10.1016/j.preteyeres.2024.101261, ISSN: 1873-1635.
Wareham LK, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target. Mol Neurodegener. 2024 Jan 1/25/2024; 19(1): 11. PMID: 38273335, PMCID: PMC10809576, PII: 10.1186/s13024-024-00704-0, DOI: 10.1186/s13024-024-00704-0, ISSN: 1750-1326.
Baratta RO, Schlumpf E, Del Buono BJ, DeLorey S, Ousler G, Calkins DJ. A Phase 2 Trial to Test Safety and Efficacy of ST-100, a Unique Collagen Mimetic Peptide Ophthalmic Solution for Dry Eye Disease. Ophthalmol Sci. 2024; 4(3): 100451. PMID: 38317866, PMCID: PMC10838901, PII: S2666-9145(23)00183-5, DOI: 10.1016/j.xops.2023.100451, ISSN: 2666-9145.
Bou Ghanem GO, Koktysh D, Baratta RO, Del Buono BJ, Schlumpf E, Wareham LK, Calkins DJ. Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head. Int J Mol Sci. 2023 Dec 12/1/2023; 24(23): PMID: 38069354, PMCID: PMC10707085, PII: ijms242317031, DOI: 10.3390/ijms242317031, ISSN: 1422-0067.
Risner ML, Ribeiro M, McGrady NR, Kagitapalli BS, Chamling X, Zack DJ, Calkins DJ. Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo. Cell Commun Signal. 2023 Oct 10/30/2023; 21(1): 305. PMID: 37904133, PMCID: PMC10614343, PII: 10.1186/s12964-023-01291-1, DOI: 10.1186/s12964-023-01291-1, ISSN: 1478-811X.
Naguib S, Backstrom JR, Artis E, Ghose P, Stahl A, Hardin R, Haider AA, Ang J, Calkins DJ, Rex TS. NRF2/ARE mediated antioxidant response to glaucoma: role of glia and retinal ganglion cells. Acta Neuropathol Commun. 2023 Oct 10/24/2023; 11(1): 171. PMID: 37875948, PMCID: PMC10594672, PII: 10.1186/s40478-023-01663-1, DOI: 10.1186/s40478-023-01663-1, ISSN: 2051-5960.
McGrady NR, Boal AM, Risner ML, Taiel M, Sahel JA, Calkins DJ. Ocular stress enhances contralateral transfer of lenadogene nolparvovec gene therapy through astrocyte networks. Mol Ther [print-electronic]. 2023 Jul 7/5/2023; 31(7): 2005-13. PMID: 37016579, PMCID: PMC10362393, PII: S1525-0016(23)00195-8, DOI: 10.1016/j.ymthe.2023.03.035, ISSN: 1525-0024.
Johnson TV, Calkins DJ, Fortune B, Goldberg JL, La Torre A, Lamba DA, Meyer JS, Reh TA, Wallace VA, Zack DJ, Baranov P. The importance of unambiguous cell origin determination in neuronal repopulation studies. IScience. 2023 Apr 4/21/2023; 26(4): 106361. PMID: 37009209, PMCID: PMC10060674, PII: S2589-0042(23)00438-8, DOI: 10.1016/j.isci.2023.106361, ISSN: 2589-0042.
Boal AM, McGrady NR, Chamling X, Kagitapalli BS, Zack DJ, Calkins DJ, Risner ML. Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy. Transl Vis Sci Technol. 2023 Apr 4/3/2023; 12(4): 1. PMID: 37010860, PMCID: PMC10080917, PII: 2785496, DOI: 10.1167/tvst.12.4.1, ISSN: 2164-2591.
Naguib S, DeJulius CR, Backstrom JR, Haider AA, Ang JM, Boal AM, Calkins DJ, Duvall CL, Rex TS. Intraocular Sustained Release of EPO-R76E Mitigates Glaucoma Pathogenesis by Activating the NRF2/ARE Pathway. Antioxidants (Basel). 2023 Feb 2/23/2023; 12(3): PMID: 36978804, PMCID: PMC10045745, PII: antiox12030556, DOI: 10.3390/antiox12030556, ISSN: 2076-3921.
Holden JM, Wareham LK, Calkins DJ. Retinal astrocyte morphology predicts integration of vascular and neuronal architecture. Front Neurosci. 2023; 17: 1244679. PMID: 37621717, PMCID: PMC10445659, DOI: 10.3389/fnins.2023.1244679, ISSN: 1662-4548.
Wareham LK, Holden JM, Bossardet OL, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Collagen mimetic peptide repair of the corneal nerve bed in a mouse model of dry eye disease. Front Neurosci. 2023; 17: 1148950. PMID: 37260844, PMCID: PMC10228686, DOI: 10.3389/fnins.2023.1148950, ISSN: 1662-4548.
Boal AM, McGrady NR, Holden JM, Risner ML, Calkins DJ. Retinal ganglion cells adapt to ionic stress in experimental glaucoma. Front Neurosci. 2023; 17: 1142668. PMID: 37051140, PMCID: PMC10083336, DOI: 10.3389/fnins.2023.1142668, ISSN: 1662-4548.
Croteau LP, Risner ML, Wareham LK, McGrady NR, Chamling X, Zack DJ, Calkins DJ. Ex Vivo Integration of Human Stem Retinal Ganglion Cells into the Mouse Retina. Cells. 2022 Oct 10/15/2022; 11(20): PMID: 36291110, PMCID: PMC9600680, PII: cells11203241, DOI: 10.3390/cells11203241, ISSN: 2073-4409.
Newman NJ, Schniederjan M, Mendoza PR, Calkins DJ, Yu-Wai-Man P, Biousse V, Carelli V, Taiel M, Rugiero F, Singh P, Rogue A, Sahel JA, Ancian P. Absence of lenadogene nolparvovec DNA in a brain tumor biopsy from a patient in the REVERSE clinical study, a case report. BMC Neurol. 2022 Jul 7/12/2022; 22(1): 257. PMID: 35820885, PMCID: PMC9277876, PII: 10.1186/s12883-022-02787-y, DOI: 10.1186/s12883-022-02787-y, ISSN: 1471-2377.
Ribeiro M, Pasini S, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Collagen Mimetic Peptides Promote Adherence and Migration of ARPE-19 Cells While Reducing Inflammatory and Oxidative Stress. Int J Mol Sci. 2022 Jun 6/23/2022; 23(13): PMID: 35806007, PMCID: PMC9266392, PII: ijms23137004, DOI: 10.3390/ijms23137004, ISSN: 1422-0067.
Wareham LK, Liddelow SA, Temple S, Benowitz LI, Di Polo A, Wellington C, Goldberg JL, He Z, Duan X, Bu G, Davis AA, Shekhar K, Torre A, Chan DC, Canto-Soler MV, Flanagan JG, Subramanian P, Rossi S, Brunner T, Bovenkamp DE, Calkins DJ. Solving neurodegeneration: common mechanisms and strategies for new treatments. Mol Neurodegener. 2022 Mar 3/21/2022; 17(1): 23. PMID: 35313950, PMCID: PMC8935795, PII: 10.1186/s13024-022-00524-0, DOI: 10.1186/s13024-022-00524-0, ISSN: 1750-1326.
Holden JM, Al Hussein Al Awamlh S, Croteau LP, Boal AM, Rex TS, Risner ML, Calkins DJ, Wareham LK. Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice. Int J Mol Sci. 2022 Mar 3/12/2022; 23(6): PMID: 35328488, PMCID: PMC8954518, PII: ijms23063066, DOI: 10.3390/ijms23063066, ISSN: 1422-0067.
Ribeiro M, McGrady NR, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Intraocular Delivery of a Collagen Mimetic Peptide Repairs Retinal Ganglion Cell Axons in Chronic and Acute Injury Models. Int J Mol Sci. 2022 Mar 3/8/2022; 23(6): PMID: 35328332, PMCID: PMC8949359, PII: ijms23062911, DOI: 10.3390/ijms23062911, ISSN: 1422-0067.
Risner ML, Pasini S, McGrady NR, Calkins DJ. Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma. Mol Neurobiol [print-electronic]. 2022 Mar; 59(3): 1366-80. PMID: 34984584, PMCID: PMC8882107, PII: 10.1007/s12035-021-02675-5, DOI: 10.1007/s12035-021-02675-5, ISSN: 1559-1182.
McGrady NR, Holden JM, Ribeiro M, Boal AM, Risner ML, Calkins DJ. Axon hyperexcitability in the contralateral projection following unilateral optic nerve crush in mice. Brain Commun. 2022; 4(5): fcac251. PMID: 36267329, PMCID: PMC9576152, PII: fcac251, DOI: 10.1093/braincomms/fcac251, ISSN: 2632-1297.
Boal AM, McGrady NR, Risner ML, Calkins DJ. Sensitivity to extracellular potassium underlies type-intrinsic differences in retinal ganglion cell excitability. Front Cell Neurosci. 2022; 16: 966425. PMID: 35990894, PMCID: PMC9390602, DOI: 10.3389/fncel.2022.966425, ISSN: 1662-5102.
Baratta RO, Schlumpf E, Buono BJD, DeLorey S, Calkins DJ. Corneal collagen as a potential therapeutic target in dry eye disease. Surv Ophthalmol [print-electronic]. 2022; 67(1): 60-7. PMID: 33882269, PII: S0039-6257(21)00104-1, DOI: 10.1016/j.survophthal.2021.04.006, ISSN: 1879-3304.
Calkins DJ, Yu-Wai-Man P, Newman NJ, Taiel M, Singh P, Chalmey C, Rogue A, Carelli V, Ancian P, Sahel JA. Biodistribution of intravitreal lenadogene nolparvovec gene therapy in nonhuman primates. Mol Ther Methods Clin Dev. 2021 Dec 12/10/2021; 23: 307-18. PMID: 34729378, PMCID: PMC8526752, PII: S2329-0501(21)00151-0, DOI: 10.1016/j.omtm.2021.09.013, ISSN: 2329-0501.
Calkins DJ. Adaptive responses to neurodegenerative stress in glaucoma. Prog Retin Eye Res [print-electronic]. 2021 Sep; 84: 100953. PMID: 33640464, PMCID: PMC8384979, PII: S1350-9462(21)00014-8, DOI: 10.1016/j.preteyeres.2021.100953, ISSN: 1873-1635.
Risner ML, Pasini S, Chamling X, McGrady NR, Goldberg JL, Zack DJ, Calkins DJ. Intrinsic Morphologic and Physiologic Development of Human Derived Retinal Ganglion Cells In Vitro. Transl Vis Sci Technol. 2021 Aug 8/12/2021; 10(10): 1. PMID: 34383881, PMCID: PMC8362626, PII: 2776589, DOI: 10.1167/tvst.10.10.1, ISSN: 2164-2591.
Risner ML, Pasini S, McGrady NR, D'Alessandro KB, Yao V, Cooper ML, Calkins DJ. Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma. Mol Neurodegener. 2021 Jun 6/5/2021; 16(1): 36. PMID: 34090501, PMCID: PMC8180099, PII: 10.1186/s13024-021-00459-y, DOI: 10.1186/s13024-021-00459-y, ISSN: 1750-1326.
Boal AM, Risner ML, Cooper ML, Wareham LK, Calkins DJ. Astrocyte Networks as Therapeutic Targets in Glaucomatous Neurodegeneration. Cells. 2021 Jun 6/2/2021; 10(6): PMID: 34199470, PMCID: PMC8228804, PII: cells10061368, DOI: 10.3390/cells10061368, ISSN: 2073-4409.
Naguib S, Backstrom JR, Gil M, Calkins DJ, Rex TS. Retinal oxidative stress activates the NRF2/ARE pathway: An early endogenous protective response to ocular hypertension. Redox Biol [print-electronic]. 2021 Jun; 42: 101883. PMID: 33579667, PMCID: PMC8113046, PII: S2213-2317(21)00031-8, DOI: 10.1016/j.redox.2021.101883, ISSN: 2213-2317.
Al Hussein Al Awamlh S, Wareham LK, Risner ML, Calkins DJ. Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration. Int J Mol Sci. 2021 Apr 4/28/2021; 22(9): PMID: 33925119, PMCID: PMC8124776, PII: ijms22094672, DOI: 10.3390/ijms22094672, ISSN: 1422-0067.
McGrady NR, Pasini S, Baratta RO, Del Buono BJ, Schlumpf E, Calkins DJ. Restoring the Extracellular Matrix: A Neuroprotective Role for Collagen Mimetic Peptides in Experimental Glaucoma. Front Pharmacol. 2021; 12: 764709. PMID: 34795592, PMCID: PMC8592892, PII: 764709, DOI: 10.3389/fphar.2021.764709, ISSN: 1663-9812.
Baratta RO, Del Buono BJ, Schlumpf E, Ceresa BP, Calkins DJ. Collagen Mimetic Peptides Promote Corneal Epithelial Cell Regeneration. Front Pharmacol. 2021; 12: 705623. PMID: 34483909, PMCID: PMC8415399, PII: 705623, DOI: 10.3389/fphar.2021.705623, ISSN: 1663-9812.
Yu-Wai-Man P, Newman NJ, Carelli V, Moster ML, Biousse V, Sadun AA, Klopstock T, Vignal-Clermont C, Sergott RC, Rudolph G, La Morgia C, Karanjia R, Taiel M, Blouin L, Burguière P, Smits G, Chevalier C, Masonson H, Salermo Y, Katz B, Picaud S, Calkins DJ, Sahel JA. Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy. Sci Transl Med. 2020 Dec 12/9/2020; 12(573): PMID: 33298565, PII: 12/573/eaaz7423, DOI: 10.1126/scitranslmed.aaz7423, ISSN: 1946-6242.
Cooper ML, Pasini S, Lambert WS, D'Alessandro KB, Yao V, Risner ML, Calkins DJ. Redistribution of metabolic resources through astrocyte networks mitigates neurodegenerative stress. Proc Natl Acad Sci U S A [print-electronic]. 2020 Aug 8/4/2020; 117(31): 18810-21. PMID: 32690710, PMCID: PMC7414143, PII: 2009425117, DOI: 10.1073/pnas.2009425117, ISSN: 1091-6490.
Lambert WS, Pasini S, Collyer JW, Formichella CR, Ghose P, Carlson BJ, Calkins DJ. Of Mice and Monkeys: Neuroprotective Efficacy of the p38 Inhibitor BIRB 796 Depends on Model Duration in Experimental Glaucoma. Sci Rep. 2020 May 5/22/2020; 10(1): 8535. PMID: 32444682, PMCID: PMC7244559, PII: 10.1038/s41598-020-65374-6, DOI: 10.1038/s41598-020-65374-6, ISSN: 2045-2322.
Risner ML, McGrady NR, Boal AM, Pasini S, Calkins DJ. TRPV1 Supports Axogenic Enhanced Excitability in Response to Neurodegenerative Stress. Front Cell Neurosci. 2020; 14: 603419. PMID: 33505248, PMCID: PMC7829306, DOI: 10.3389/fncel.2020.603419, ISSN: 1662-5102.
Wareham LK, Risner ML, Calkins DJ. Protect, Repair, and Regenerate: Towards Restoring Vision in Glaucoma. Curr Ophthalmol Rep [print-electronic]. 2020; 8(4): 301-10. PMID: 33269115, PMCID: PMC7686214, PII: 259, DOI: 10.1007/s40135-020-00259-5, ISSN: 2167-4868.
Wareham LK, Calkins DJ. The Neurovascular Unit in Glaucomatous Neurodegeneration. Front Cell Dev Biol. 2020; 8: 452. PMID: 32656207, PMCID: PMC7325980, DOI: 10.3389/fcell.2020.00452, ISSN: 2296-634X.
McGrady NR, Risner ML, Vest V, Calkins DJ. TRPV1 Tunes Optic Nerve Axon Excitability in Glaucoma. Front Physiol. 2020; 11: 249. PMID: 32273850, PMCID: PMC7113399, DOI: 10.3389/fphys.2020.00249, ISSN: 1664-042X.
Risner ML, McGrady NR, Pasini S, Lambert WS, Calkins DJ. Elevated ocular pressure reduces voltage-gated sodium channel NaV1.2 protein expression in retinal ganglion cell axons. Exp Eye Res [print-electronic]. 2020 Jan; 190: 107873. PMID: 31734278, PMCID: PMC6957720, PII: S0014-4835(19)30587-1, DOI: 10.1016/j.exer.2019.107873, ISSN: 1096-0007.
Kubota R, Calkins DJ, Henry SH, Linsenmeier RA. Emixustat Reduces Metabolic Demand of Dark Activity in the Retina. Invest Ophthalmol Vis Sci. 2019 Nov 11/1/2019; 60(14): 4924-30. PMID: 31770432, PII: 2756154, DOI: 10.1167/iovs.19-28194, ISSN: 1552-5783.
Lambert WS, Carlson BJ, Ghose P, Vest VD, Yao V, Calkins DJ. Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate. Sci Rep. 2019 Aug 8/9/2019; 9(1): 11572. PMID: 31399621, PMCID: PMC6689098, PII: 10.1038/s41598-019-48054-y, DOI: 10.1038/s41598-019-48054-y, ISSN: 2045-2322.
Bernardo-Colón A, Vest V, Cooper ML, Naguib SA, Calkins DJ, Rex TS. Progression and Pathology of Traumatic Optic Neuropathy From Repeated Primary Blast Exposure. Front Neurosci. 2019; 13: 719. PMID: 31354422, PMCID: PMC6637732, DOI: 10.3389/fnins.2019.00719, ISSN: 1662-4548.
Bernardo-Colón A, Vest V, Clark A, Cooper ML, Calkins DJ, Harrison FE, Rex TS. Antioxidants prevent inflammation and preserve the optic projection and visual function in experimental neurotrauma. Cell Death Dis. 2018 Oct 10/26/2018; 9(11): 1097. PMID: 30367086, PMCID: PMC6203845, PII: 10.1038/s41419-018-1061-4, DOI: 10.1038/s41419-018-1061-4, ISSN: 2041-4889.
Laughter MR, Bardill JR, Ammar DA, Pena B, Calkins DJ, Park D. Injectable Neurotrophic Factor Delivery System Supporting Retinal Ganglion Cell Survival and Regeneration Following Optic Nerve Crush. ACS Biomater Sci Eng [print-electronic]. 2018 Sep 9/10/2018; 4(9): 3374-83. PMID: 31431919, PMCID: PMC6701853, DOI: 10.1021/acsbiomaterials.8b00803, ISSN: 2373-9878.
Cooper ML, Collyer JW, Calkins DJ. Astrocyte remodeling without gliosis precedes optic nerve Axonopathy. Acta Neuropathol Commun. 2018 May 5/10/2018; 6(1): 38. PMID: 29747701, PMCID: PMC5946396, PII: 10.1186/s40478-018-0542-0, DOI: 10.1186/s40478-018-0542-0, ISSN: 2051-5960.
Risner ML, Pasini S, Cooper ML, Lambert WS, Calkins DJ. Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2018 Mar 3/6/2018; 115(10): E2393-E2402. PMID: 29463759, PII: 1714888115, DOI: 10.1073/pnas.1714888115, ISSN: 1091-6490.
Risner ML, Pasini S, Cooper ML, Lambert WS, Calkins DJ. Axogenic mechanism enhances retinal ganglion cell excitability during early progression in glaucoma. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2018 Mar 3/6/2018; 115(10): E2393-E2402. PMID: 29463759, PII: 1714888115, DOI: 10.1073/pnas.1714888115, ISSN: 1091-6490.
Calkins DJ, Lambert WS, Formichella CR, McLaughlin WM, Sappington RM. The Microbead Occlusion Model of Ocular Hypertension in Mice. Methods Mol. Biol. 2018; 1695: 23-39. PMID: 29190015, DOI: 10.1007/978-1-4939-7407-8_3, ISSN: 1940-6029.
Calkins DJ, Lambert WS, Formichella CR, McLaughlin WM, Sappington RM. The Microbead Occlusion Model of Ocular Hypertension in Mice. Methods Mol. Biol. 2018; 1695: 23-39. PMID: 29190015, DOI: 10.1007/978-1-4939-7407-8_3, ISSN: 1940-6029.
Calkins DJ, Sternberg P. The Solar Eclipse of 2017-A (Protected) View From the Path of Totality. JAMA Ophthalmol. 2017 Sep 9/1/2017; 135(9): 907-8. PMID: 28820916, PII: 2648904, DOI: 10.1001/jamaophthalmol.2017.2936, ISSN: 2168-6173.
Calkins DJ, Sternberg P. The Solar Eclipse of 2017-A (Protected) View From the Path of Totality. JAMA Ophthalmol. 2017 Sep 9/1/2017; 135(9): 907-8. PMID: 28820916, PII: 2648904, DOI: 10.1001/jamaophthalmol.2017.2936, ISSN: 2168-6173.
Calkins DJ, Pekny M, Cooper ML, Benowitz L, . The challenge of regenerative therapies for the optic nerve in glaucoma. Exp. Eye Res [print-electronic]. 2017 Apr; 157: 28-33. PMID: 28153739, PII: S0014-4835(17)30069-6, DOI: 10.1016/j.exer.2017.01.007, ISSN: 1096-0007.
Calkins DJ, Pekny M, Cooper ML, Benowitz L, . The challenge of regenerative therapies for the optic nerve in glaucoma. Exp. Eye Res [print-electronic]. 2017 Apr; 157: 28-33. PMID: 28153739, PII: S0014-4835(17)30069-6, DOI: 10.1016/j.exer.2017.01.007, ISSN: 1096-0007.
Anderson DMG, Lambert W, Calkins DJ, Ablonczy Z, Crouch RK, Caprioli RM, Schey KL. Imaging MS of Rodent Ocular Tissues and the Optic Nerve. Methods Mol. Biol. 2017; 1618: 15-27. PMID: 28523496, DOI: 10.1007/978-1-4939-7051-3_3, ISSN: 1940-6029.
Lambert WS, Carlson BJ, Formichella CR, Sappington RM, Ahlem C, Calkins DJ. Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma. Front Neurosci. 2017; 11: 45. PMID: 28223915, PMCID: PMC5293777, DOI: 10.3389/fnins.2017.00045, ISSN: 1662-4548.
Lambert WS, Carlson BJ, Formichella CR, Sappington RM, Ahlem C, Calkins DJ. Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma. Front Neurosci. 2017; 11: 45. PMID: 28223915, PMCID: PMC5293777, DOI: 10.3389/fnins.2017.00045, ISSN: 1662-4548.
Anderson DMG, Lambert W, Calkins DJ, Ablonczy Z, Crouch RK, Caprioli RM, Schey KL. Imaging MS of Rodent Ocular Tissues and the Optic Nerve. Methods Mol. Biol. 2017; 1618: 15-27. PMID: 28523496, DOI: 10.1007/978-1-4939-7051-3_3, ISSN: 1940-6029.
Bosco A, Breen KT, Anderson SR, Steele MR, Calkins DJ, Vetter ML. Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. Exp. Eye Res [print-electronic]. 2016 Sep; 150: 34-43. PMID: 26851485, PMCID: PMC4972706, PII: S0014-4835(16)30013-6, DOI: 10.1016/j.exer.2016.01.014, ISSN: 1096-0007.
Cooper ML, Crish SD, Inman DM, Horner PJ, Calkins DJ. Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Exp. Eye Res [print-electronic]. 2016 Sep; 150: 22-33. PMID: 26646560, PMCID: PMC4889569, PII: S0014-4835(15)30074-9, DOI: 10.1016/j.exer.2015.11.016, ISSN: 1096-0007.
Bosco A, Breen KT, Anderson SR, Steele MR, Calkins DJ, Vetter ML. Glial coverage in the optic nerve expands in proportion to optic axon loss in chronic mouse glaucoma. Exp. Eye Res [print-electronic]. 2016 Sep; 150: 34-43. PMID: 26851485, PMCID: PMC4972706, PII: S0014-4835(16)30013-6, DOI: 10.1016/j.exer.2016.01.014, ISSN: 1096-0007.
Cooper ML, Crish SD, Inman DM, Horner PJ, Calkins DJ. Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA/2J mouse model of glaucoma. Exp. Eye Res [print-electronic]. 2016 Sep; 150: 22-33. PMID: 26646560, PMCID: PMC4889569, PII: S0014-4835(15)30074-9, DOI: 10.1016/j.exer.2015.11.016, ISSN: 1096-0007.
Breen KT, Anderson SR, Steele MR, Calkins DJ, Bosco A, Vetter ML. Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma. Front Neurosci. 2016; 10: 526. PMID: 27932942, PMCID: PMC5123443, DOI: 10.3389/fnins.2016.00526, ISSN: 1662-4548.
Breen KT, Anderson SR, Steele MR, Calkins DJ, Bosco A, Vetter ML. Loss of Fractalkine Signaling Exacerbates Axon Transport Dysfunction in a Chronic Model of Glaucoma. Front Neurosci. 2016; 10: 526. PMID: 27932942, PMCID: PMC5123443, DOI: 10.3389/fnins.2016.00526, ISSN: 1662-4548.
Bond WS, Hines-Beard J, GoldenMerry YL, Davis M, Farooque A, Sappington RM, Calkins DJ, Rex TS. Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma. Mol. Ther [print-electronic]. 2015 Oct 10/27/2015; PMID: 26502777, PII: mt2015198, DOI: 10.1038/mt.2015.198, ISSN: 1525-0024.
Crish SD, Calkins DJ. Central visual pathways in glaucoma: evidence for distal mechanisms of neuronal self-repair. J Neuroophthalmol. 2015 Sep; 35 Suppl 1: S29-37. PMID: 26274834, PII: 00041327-201509001-00005, DOI: 10.1097/WNO.0000000000000291, ISSN: 1536-5166.
Lambert WS, Carlson BJ, van der Ende AE, Shih G, Dobish JN, Calkins DJ, Harth E. Nanosponge-Mediated Drug Delivery Lowers Intraocular Pressure. Transl Vis Sci Technol. 2015 Jan; 4(1): 1. PMID: 25599009, PMCID: PMC4294067, DOI: 10.1167/tvst.4.1.1, ISSN: 2164-2591.
Sappington RM, Sidorova T, Ward NJ, Chakravarthy R, Ho KW, Calkins DJ. Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress. Channels (Austin). 2015; 9(2): 102-13. PMID: 25713995, PMCID: PMC4594535, DOI: 10.1080/19336950.2015.1009272, ISSN: 1933-6969.
Weitlauf C, Ward NJ, Lambert WS, Sidorova TN, Ho KW, Sappington RM, Calkins DJ. Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation. J. Neurosci. 2014 Nov 11/12/2014; 34(46): 15369-81. PMID: 25392504, PMCID: PMC4228139, PII: 34/46/15369, DOI: 10.1523/JNEUROSCI.3424-14.2014, ISSN: 1529-2401.
Ho KW, Lambert WS, Calkins DJ. Activation of the TRPV1 cation channel contributes to stress-induced astrocyte migration. Glia [print-electronic]. 2014 Sep; 62(9): 1435-51. PMID: 24838827, PMCID: PMC4107153, DOI: 10.1002/glia.22691, ISSN: 1098-1136.
Ward NJ, Ho KW, Lambert WS, Weitlauf C, Calkins DJ. Absence of transient receptor potential vanilloid-1 accelerates stress-induced axonopathy in the optic projection. J. Neurosci. 2014 Feb 2/26/2014; 34(9): 3161-70. PMID: 24573275, PMCID: PMC3935081, PII: 34/9/3161, DOI: 10.1523/JNEUROSCI.4089-13.2014, ISSN: 1529-2401.
Calkins DJ. Age-related changes in the visual pathways: blame it on the axon. Invest. Ophthalmol. Vis. Sci. 2013 Dec; 54(14): ORSF37-41. PMID: 24335066, PMCID: PMC3864377, PII: 54/14/ORSF37, DOI: 10.1167/iovs.13-12784, ISSN: 1552-5783.
Dapper JD, Crish SD, Pang IH, Calkins DJ. Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy. Neurobiol. Dis [print-electronic]. 2013 Nov; 59: 26-37. PMID: 23859799, PMCID: PMC3775981, PII: S0969-9961(13)00195-2, DOI: 10.1016/j.nbd.2013.07.001, ISSN: 1095-953X.
Crish SD, Dapper JD, MacNamee SE, Balaram P, Sidorova TN, Lambert WS, Calkins DJ. Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target. Neuroscience [print-electronic]. 2013 Jan 1/15/2013; 229: 55-70. PMID: 23159315, PMCID: PMC3534890, PII: S0306-4522(12)01098-6, DOI: 10.1016/j.neuroscience.2012.10.069, ISSN: 1873-7544.
Anderson DM, Mills D, Spraggins J, Lambert WS, Calkins DJ, Schey KL. High-resolution matrix-assisted laser desorption ionization-imaging mass spectrometry of lipids in rodent optic nerve tissue. Mol. Vis [print-electronic]. 2013; 19: 581-92. PMID: 23559852, PMCID: PMC3611942, ISSN: 1090-0535.
Calkins DJ. Critical pathogenic events underlying progression of neurodegeneration in glaucoma. Prog Retin Eye Res [print-electronic]. 2012 Nov; 31(6): 702-19. PMID: 22871543, PMCID: PMC3472111, PII: S1350-9462(12)00053-5, DOI: 10.1016/j.preteyeres.2012.07.001, ISSN: 1873-1635.
Calkins DJ, Horner PJ. The cell and molecular biology of glaucoma: axonopathy and the brain. Invest. Ophthalmol. Vis. Sci. 2012 May; 53(5): 2482-4. PMID: 22562846, PMCID: PMC3998097, PII: 53/5/2482, DOI: 10.1167/iovs.12-9483i, ISSN: 1552-5783.
Shih GC, Calkins DJ. Secondary neuroprotective effects of hypotensive drugs and potential mechanisms of action. Expert Rev Ophthalmol. 2012 Apr; 7(2): 161-75. PMID: 22737176, PMCID: PMC3379897, DOI: 10.1586/eop.12.13, ISSN: 1746-9899.
Ho KW, Ward NJ, Calkins DJ. TRPV1: a stress response protein in the central nervous system. Am J Neurodegener Dis [print-electronic]. 2012; 1(1): 1-14. PMID: 22737633, PMCID: PMC3560445, ISSN: 2165-591X.
Crish SD, Calkins DJ. Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms. Neuroscience [print-electronic]. 2011 Mar 3/10/2011; 176: 1-11. PMID: 21187126, PMCID: PMC3040267, PII: S0306-4522(10)01641-6, DOI: 10.1016/j.neuroscience.2010.12.036, ISSN: 1873-7544.
Lambert WS, Ruiz L, Crish SD, Wheeler LA, Calkins DJ. Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons. Mol Neurodegener. 2011; 6(1): 4. PMID: 21232114, PMCID: PMC3035592, PII: 1750-1326-6-4, DOI: 10.1186/1750-1326-6-4, ISSN: 1750-1326.
Chen H, Wei X, Cho KS, Chen G, Sappington R, Calkins DJ, Chen DF. Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse. Invest. Ophthalmol. Vis. Sci. 2011 Jan; 52(1): 36-44. PMID: 20702815, PMCID: PMC3053285, PII: iovs.09-5115, DOI: 10.1167/iovs.09-5115, ISSN: 1552-5783.
Baltan S, Inman DM, Danilov CA, Morrison RS, Calkins DJ, Horner PJ. Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. J. Neurosci. 2010 Apr 4/21/2010; 30(16): 5644-52. PMID: 20410117, PMCID: PMC2884009, PII: 30/16/5644, DOI: 10.1523/JNEUROSCI.5956-09.2010, ISSN: 1529-2401.
Crish SD, Sappington RM, Inman DM, Horner PJ, Calkins DJ. Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Mar 3/16/2010; 107(11): 5196-201. PMID: 20194762, PMCID: PMC2841892, PII: 0913141107, DOI: 10.1073/pnas.0913141107, ISSN: 1091-6490.
Sappington RM, Carlson BJ, Crish SD, Calkins DJ. The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Jan; 51(1): 207-16. PMID: 19850836, PMCID: PMC2869054, PII: iovs.09-3947, DOI: 10.1167/iovs.09-3947, ISSN: 1552-5783.
Sappington RM, Sidorova T, Long DJ, Calkins DJ. TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2009 Feb; 50(2): 717-28. PMID: 18952924, PMCID: PMC3549616, PII: iovs.08-2321, DOI: 10.1167/iovs.08-2321, ISSN: 1552-5783.
Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, Sappington RM, Calkins DJ. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J. Neurosci. 2008 Nov 11/12/2008; 28(46): 12085-96. PMID: 19005073, PMCID: PMC2683273, PII: 28/46/12085, DOI: 10.1523/JNEUROSCI.3200-08.2008, ISSN: 1529-2401.
Calkins DJ, Horner PJ, Roberts R, Gradianu M, Berkowitz BA. Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2008 Nov; 49(11): 5083-8. PMID: 18552381, PMCID: PMC2586056, PII: iovs.08-2205, DOI: 10.1167/iovs.08-2205, ISSN: 1552-5783.
Sappington RM, Calkins DJ. Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2008 Jul; 49(7): 3004-17. PMID: 18362111, PMCID: PMC4139938, PII: iovs.07-1355, DOI: 10.1167/iovs.07-1355, ISSN: 1552-5783.
Bosco A, Inman DM, Steele MR, Wu G, Soto I, Marsh-Armstrong N, Hubbard WC, Calkins DJ, Horner PJ, Vetter ML. Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2008 Apr; 49(4): 1437-46. PMID: 18385061, PII: 49/4/1437, DOI: 10.1167/iovs.07-1337, ISSN: 0146-0404.
Buckingham BP, Inman DM, Lambert W, Oglesby E, Calkins DJ, Steele MR, Vetter ML, Marsh-Armstrong N, Horner PJ. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J. Neurosci. 2008 Mar 3/12/2008; 28(11): 2735-44. PMID: 18337403, PII: 28/11/2735, DOI: 10.1523/JNEUROSCI.4443-07.2008, ISSN: 1529-2401.
Calkins, D.J.. A Neurological Perspective of Glaucoma. Glaucoma Today. 2008; ((September/October)): 18-20.
Berkowitz BA, Roberts R, Luan H, Bissig D, Bui BV, Gradianu M, Calkins DJ, Vingrys AJ. Manganese-enhanced MRI studies of alterations of intraretinal ion demand in models of ocular injury. Invest. Ophthalmol. Vis. Sci. 2007 Aug; 48(8): 3796-804. PMID: 17652754, PMCID: PMC2041849, PII: 48/8/3796, DOI: 10.1167/iovs.06-1278, ISSN: 0146-0404.
Calkins DJ, Sterling P. Microcircuitry for two types of achromatic ganglion cell in primate fovea. J. Neurosci. 2007 Mar 3/7/2007; 27(10): 2646-53. PMID: 17344402, PII: 27/10/2646, DOI: 10.1523/JNEUROSCI.4739-06.2007, ISSN: 1529-2401.
Hanna MC, Calkins DJ. Expression of genes encoding glutamate receptors and transporters in rod and cone bipolar cells of the primate retina determined by single-cell polymerase chain reaction. Mol. Vis. 2007; 13: 2194-208. PMID: 18087239, PII: v13/a249, ISSN: 1090-0535.
Sappington RM, Calkins DJ. Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin/proteasome pathway and NFkappaB. Invest. Ophthalmol. Vis. Sci. 2006 Sep; 47(9): 3860-9. PMID: 16936098, PII: 47/9/3860, DOI: 10.1167/iovs.05-1408, ISSN: 0146-0404.
DiLoreto DA, Luo C, Calkins DJ, del Cerro M. An ultrastructural study of the pathology of the retinal pigment epithelium, Bruch's membrane, and the choriocapillaris in the aged Fischer 344 rat. Curr. Eye Res. 2006 Sep; 31(9): 749-63. PMID: 16966148, PII: J762R60681856480, DOI: 10.1080/02713680600864782, ISSN: 0271-3683.
Sappington RM, Chan M, Calkins DJ. Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest. Ophthalmol. Vis. Sci. 2006 Jul; 47(7): 2932-42. PMID: 16799036, PII: 47/7/2932, DOI: 10.1167/iovs.05-1407, ISSN: 0146-0404.
Inman DM, Sappington RM, Horner PJ, Calkins DJ. Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2006 Mar; 47(3): 986-96. PMID: 16505033, PII: 47/3/986, DOI: 10.1167/iovs.05-0925, ISSN: 0146-0404.
Steele MR, Inman DM, Calkins DJ, Horner PJ, Vetter ML. Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma. Invest. Ophthalmol. Vis. Sci. 2006 Mar; 47(3): 977-85. PMID: 16505032, PII: 47/3/977, DOI: 10.1167/iovs.05-0865, ISSN: 0146-0404.
Hanna MC, Calkins DJ. Expression and sequences of genes encoding glutamate receptors and transporters in primate retina determined using 3'-end amplification polymerase chain reaction. Mol. Vis. 2006; 12: 961-76. PMID: 16943768, PII: v12/a108, ISSN: 1090-0535.
Calkins DJ. Localization of ionotropic glutamate receptors to invaginating dendrites at the cone synapse in primate retina. Vis. Neurosci. 2005 Jul; 22(4): 469-77. PMID: 16212704, PII: S0952523805224082, DOI: 10.1017/S0952523805224082, ISSN: 0952-5238.
Calkins DJ. Remembering Bob Rodieck: 1937-2003. Vis. Neurosci. 2005 Jul; 22(4): 379-81. PMID: 16212696, PII: S0952523805224136, DOI: 10.1017/S0952523805224136, ISSN: 0952-5238.
Wilson JD, Bigelow CE, Calkins DJ, Foster TH. Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling. Biophys. J [print-electronic]. 2005 Apr; 88(4): 2929-38. PMID: 15653724, PMCID: PMC1305387, PII: S0006-3495(05)73345-2, DOI: 10.1529/biophysj.104.054528, ISSN: 0006-3495.
Calkins DJ, Sappington RM, Hendry SH. Morphological identification of ganglion cells expressing the alpha subunit of type II calmodulin-dependent protein kinase in the macaque retina. J. Comp. Neurol. 2005 Jan 1/10/2005; 481(2): 194-209. PMID: 15562509, DOI: 10.1002/cne.20368, ISSN: 0021-9967.
Calkins, DJ. [place unknown: publisher unknown]; 2004.
Sappington RM, Pearce DA, Calkins DJ. Optic nerve degeneration in a murine model of juvenile ceroid lipofuscinosis. Invest. Ophthalmol. Vis. Sci. 2003 Sep; 44(9): 3725-31. PMID: 12939285, ISSN: 0146-0404.
Pasternak, Tatiana; Bisley, James; Calkins, David J.. Visual processing in the primate brain. In Handbook of Psychology, Volume 3, Biological Psychology (M. Gallagher & R. Nelson, ed.), John Wiley and Sons. [place unknown: publisher unknown]; 2003.
Harvey DM, Calkins DJ. Localization of kainate receptors to the presynaptic active zone of the rod photoreceptor in primate retina. Vis. Neurosci. 2002 Sep; 19(5): 681-92. PMID: 12507334, PII: S0952523802195137, ISSN: 0952-5238.
Yao PJ, Coleman PD, Calkins DJ. High-resolution localization of clathrin assembly protein AP180 in the presynaptic terminals of mammalian neurons. J. Comp. Neurol. 2002 May 5/27/2002; 447(2): 152-62. PMID: 11977118, DOI: 10.1002/cne.10217, ISSN: 0021-9967.
Calkins DJ. Seeing with S cones. Prog Retin Eye Res. 2001 May; 20(3): 255-87. PMID: 11286894, PII: S1350-9462(00)00026-4, ISSN: 1350-9462.
Calkins DJ. Representation of cone signals in the primate retina. J Opt Soc Am A Opt Image Sci Vis. 2000 Mar; 17(3): 597-606. PMID: 10708041, ISSN: 1084-7529.
Calkins DJ, Sterling P. Evidence that circuits for spatial and color vision segregate at the first retinal synapse. Neuron. 1999 Oct; 24(2): 313-21. PMID: 10571226, PII: S0896-6273(00)80846-6, ISSN: 0896-6273.
Calkins, David J.. Synaptic organization of cone pathways in the primate retina. In Color Vision: from Molecular Genetics to Perception (K. Gegenfurtner & L. Sharpe, eds.), Cambridge University Press. 1999.
Hendry SH, Calkins DJ. Neuronal chemistry and functional organization in the primate visual system. Trends Neurosci. 1998 Aug; 21(8): 344-9. PMID: 9720602, PII: S0166-2236(98)01245-4, ISSN: 0166-2236.
Calkins DJ, Tsukamoto Y, Sterling P.. Microcircuitry and mosaic of a blue-yellow ganglion cell in the primate retina. J Neurosci. 1998; 18((9)): 3373-85.
Calkins DJ, Tsukamoto Y, Sterling P. Foveal cones form basal as well as invaginating junctions with diffuse ON bipolar cells. Vision Res. 1996 Nov; 36(21): 3373-81. PMID: 8977004, PII: 0042-6989(95)00333-9, ISSN: 0042-6989.
Calkins DJ, Sterling P. Absence of spectrally specific lateral inputs to midget ganglion cells in primate retina. Nature. 1996 Jun 6/13/1996; 381(6583): 613-5. PMID: 8637598, DOI: 10.1038/381613a0, ISSN: 0028-0836.
Calkins DJ, Schein SJ, Tsukamoto Y, Sterling P. M and L cones in macaque fovea connect to midget ganglion cells by different numbers of excitatory synapses. Nature. 1994 Sep 9/1/1994; 371(6492): 70-2. PMID: 8072528, DOI: 10.1038/371070a0, ISSN: 0028-0836.
Calkins DJ, Thornton JE, Pugh EN. Monochromatism determined at a long-wavelength/middle-wavelength cone-antagonistic locus. Vision Res. 1992 Dec; 32(12): 2349-67. PMID: 1288011, PII: 0042-6989(92)90098-4, ISSN: 0042-6989.
Available Postdoctoral Position Details
Posted: 8/7/2014
The laboratory seeks highly motivated neuroscientists for studies of mechanisms of neurodegeneration, neuronal self-repair, and regenerative medicine. Applicants must have excellent communication skills and references.
The laboratory seeks highly motivated neuroscientists for studies of mechanisms of neurodegeneration, neuronal self-repair, and regenerative medicine. Applicants must have excellent communication skills and references.