Andre M. Diedrich, M.D., Ph.D.

Research Professor

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Faculty Appointments
Research Professor of Medicine Research Professor of Biomedical Engineering
Ph.D., Medical Cybernetics, Humboldt-Universität zu Berlin, Berlin, GermanyM.D., Medicine, I.M. Sechenov Moscow Medical Academy, Moscow, RussiaC.E., Mathematics and Physics, Martin Luther University of Halle-Wittenberg, Halle, Germany
Office Address
Vanderbilt Autonomic Dysfunction Center
Suite AA 3228 MCN
1161 21st Avenue South
Nashville, TN 37232-2195
Research Description
Our laboratory is interested in identifying the mechanisms of neural regulation of heart rate and blood pressure in normal individuals, in patients with cardiovascular or neurological disorders, as well in astronauts during weightlessness.

We apply bench-to-bedside approach that merges clinical research and basic research, merges human research and aninmal research, merges biomedical engineering and medicine.

The laboratory focuses on transgenic mice as models of human disease, pharmacologic testing, tests for human autonomic function, digital signal processing and modeling of neural control of heart rate and blood pressure.
Research Keywords
neuroscience, autonomic, blood pressure, muscle sympathetic nerve actvity, syncope, fainting, microgravity, NASA
Clinical Research Keywords
Syncope, Fainting, Orthostatic Intolerance, Postural Orthostatic Tachycardia
Jordan J, Diedrich A, Grassi G, Tank J. Living with severe orthostatic hypotension. J. Hypertens. 2016 Oct; 34(10): 1942-4. PMID: 27579701, PII: 00004872-201610000-00005, DOI: 10.1097/HJH.0000000000001038, ISSN: 1473-5598.

Gamboa A, Figueroa R, Paranjape SY, Farley G, Diedrich A, Biaggioni I. Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension. Hypertension [print-electronic]. 2016 Oct; 68(4): 1004-10. PMID: 27528067, PMCID: PMC5016238, PII: HYPERTENSIONAHA.116.07681, DOI: 10.1161/HYPERTENSIONAHA.116.07681, ISSN: 1524-4563.

Harder R, Malow BA, Goodpaster RL, Iqbal F, Halbower A, Goldman SE, Fawkes DB, Wang L, Shi Y, Baudenbacher F, Diedrich A. Heart rate variability during sleep in children with autism spectrum disorder. Clin. Auton. Res [print-electronic]. 2016 Aug 8/4/2016; PMID: 27491489, PII: 10.1007/s10286-016-0375-5, DOI: 10.1007/s10286-016-0375-5, ISSN: 1619-1560.

Okamoto LE, Diedrich A, Baudenbacher FJ, Harder R, Whitfield JS, Iqbal F, Gamboa A, Shibao CA, Black BK, Raj SR, Robertson D, Biaggioni I. Efficacy of Servo-Controlled Splanchnic Venous Compression in the Treatment of Orthostatic Hypotension: A Randomized Comparison With Midodrine. Hypertension [print-electronic]. 2016 Aug; 68(2): 418-26. PMID: 27271310, PMCID: PMC4945429, PII: HYPERTENSIONAHA.116.07199, DOI: 10.1161/HYPERTENSIONAHA.116.07199, ISSN: 1524-4563.

Zeng F, Kloepfer LA, Finney C, Diedrich A, Harris RC. Specific endothelial heparin-binding EGF-like growth factor deletion ameliorates renal injury induced by chronic angiotensin II infusion. Am. J. Physiol. Renal Physiol [print-electronic]. 2016 May 5/25/2016; ajprenal.00377.2015. PMID: 27226110, PII: ajprenal.00377.2015, DOI: 10.1152/ajprenal.00377.2015, ISSN: 1522-1466.

Mar PL, Nwazue V, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Loyd JE, Hemnes AR, Robbins IM, Robertson D, Raj SR, Austin ED. Valsalva Maneuver in Pulmonary Arterial Hypertension: Susceptibility to Syncope and Autonomic Dysfunction. Chest [print-electronic]. 2016 May; 149(5): 1252-60. PMID: 26836906, PMCID: PMC4944774, PII: S0012-3692(15)00181-6, DOI: 10.1016/j.chest.2015.11.015, ISSN: 1931-3543.

Lateef DM, Xiao C, Brychta RJ, Diedrich A, Schnermann J, Reitman ML. Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanism. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2016 Apr 4/1/2016; 310(7): H891-8. PMID: 26801314, PMCID: PMC4865066, PII: ajpheart.00963.2015, DOI: 10.1152/ajpheart.00963.2015, ISSN: 1522-1539.

Eckberg DL, Diedrich A, Cooke WH, Biaggioni I, Buckey JC, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG. Respiratory modulation of human autonomic function: long-term neuroplasticity in space. J. Physiol. (Lond.) [print-electronic]. 2016 Mar 3/29/2016; PMID: 27029027, DOI: 10.1113/JP271656, ISSN: 1469-7793.

Eckberg DL, Cooke WH, Diedrich A, Biaggioni I, Buckey JC, Pawelczyk JA, Ertl AC, Cox JF, Kuusela TA, Tahvanainen KU, Mano T, Iwase S, Baisch FJ, Levine BD, Adams-Huet B, Robertson D, Blomqvist CG. Respiratory modulation of human autonomic function on Earth. J. Physiol. (Lond.) [print-electronic]. 2016 Mar 3/29/2016; PMID: 27028958, DOI: 10.1113/JP271654, ISSN: 1469-7793.

Heusser K, Tank J, Brinkmann J, Menne J, Kaufeld J, Linnenweber-Held S, Beige J, Wilhelmi M, Diedrich A, Haller H, Jordan J. Acute Response to Unilateral Unipolar Electrical Carotid Sinus Stimulation in Patients With Resistant Arterial Hypertension. Hypertension [print-electronic]. 2016 Mar; 67(3): 585-91. PMID: 26831195, PMCID: PMC4773922, PII: HYPERTENSIONAHA.115.06486, DOI: 10.1161/HYPERTENSIONAHA.115.06486, ISSN: 1524-4563.

Bagai K, Peltier AC, Malow BA, Diedrich A, Shibao CA, Black BK, Paranjape SY, Orozco C, Biaggioni I, Robertson D, Raj SR. Objective Sleep Assessments in Patients with Postural Tachycardia Syndrome using Overnight Polysomnograms. J Clin Sleep Med. 2016; 12(5): 727-33. PMID: 26951415, PMCID: PMC4865560, PII: jc-00367-15, DOI: 10.5664/jcsm.5806, ISSN: 1550-9397.

Heusser K, Tank J, Brinkmann J, Schroeder C, May M, Großhennig A, Wenzel D, Diedrich A, Sweep FC, Mehling H, Luft FC, Jordan J. Preserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High-Fidelity Cardiovascular Phenotyping. J Am Heart Assoc. 2016 Jan; 5(1): PMID: 26764413, PMCID: PMC4859385, PII: JAHA.115.002674, DOI: 10.1161/JAHA.115.002674, ISSN: 2047-9980.

Okamoto LE, Raj SR, Gamboa A, Shibao CA, Arnold AC, Garland EM, Black BK, Farley G, Diedrich A, Biaggioni I. Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2015 Dec 12/15/2015; 309(12): H2098-107. PMID: 26453329, PMCID: PMC4698423, PII: ajpheart.00409.2015, DOI: 10.1152/ajpheart.00409.2015, ISSN: 1522-1539.

Celedonio JE, Arnold AC, Dupont WD, Ramirez CE, Diedrich A, Okamoto LE, Raj SR, Robertson D, Peltier AC, Biaggioni I, Shibao CA. Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure. Clin. Auton. Res [print-electronic]. 2015 Oct; 25(5): 309-15. PMID: 26359268, PMCID: PMC4785595, PII: 10.1007/s10286-015-0307-9, DOI: 10.1007/s10286-015-0307-9, ISSN: 1619-1560.

Tank J, Heusser K, Brinkmann J, Schmidt BM, Menne J, Bauersachs J, Haller H, Diedrich A, Jordan J. Spike rate of multi-unit muscle sympathetic nerve fibers after catheter-based renal nerve ablation. J Am Soc Hypertens [print-electronic]. 2015 Oct; 9(10): 794-801. PMID: 26324745, PMCID: PMC4785601, PII: S1933-1711(15)00610-5, DOI: 10.1016/j.jash.2015.07.012, ISSN: 1878-7436.

Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D. Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise. Physiol. Genomics [print-electronic]. 2015 Sep; 47(9): 400-6. PMID: 26058836, PMCID: PMC4556937, PII: physiolgenomics.00124.2014, DOI: 10.1152/physiolgenomics.00124.2014, ISSN: 1531-2267.

Mar PL, Shibao CA, Garland EM, Black BK, Biaggioni I, Diedrich A, Paranjape SY, Robertson D, Raj SR. Neurogenic hyperadrenergic orthostatic hypotension: a newly recognized variant of orthostatic hypotension in older adults with elevated norepinephrine (noradrenaline). Clin. Sci. 2015 Jul; 129(2): 107-16. PMID: 25706983, PMCID: PMC4417057, PII: CS20140766, DOI: 10.1042/CS20140766, ISSN: 1470-8736.

Mandsager KT, Robertson D, Diedrich A. The function of the autonomic nervous system during spaceflight. Clin. Auton. Res [print-electronic]. 2015 Jun; 25(3): 141-51. PMID: 25820827, PMCID: PMC4465859, DOI: 10.1007/s10286-015-0285-y, ISSN: 1619-1560.

Gamboa A, Paranjape SY, Black BK, Arnold AC, Figueroa R, Okamoto LE, Nwazue VC, Diedrich A, Plummer WD, Dupont WD, Robertson D, Raj SR. Inspiratory resistance improves postural tachycardia: a randomized study. Circ Arrhythm Electrophysiol [print-electronic]. 2015 Jun; 8(3): 651-8. PMID: 25792354, PMCID: PMC4472504, PII: CIRCEP.114.002605, DOI: 10.1161/CIRCEP.114.002605, ISSN: 1941-3084.

Hallgren E, Migeotte PF, Kornilova L, Delière Q, Fransen E, Glukhikh D, Moore ST, Clément G, Diedrich A, MacDougall H, Wuyts FL. Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space. Sci Rep. 2015; 5: 17627. PMID: 26671177, PMCID: PMC4680856, PII: srep17627, DOI: 10.1038/srep17627, ISSN: 2045-2322.

Pezawas T, Diedrich A, Winker R, Robertson D, Richter B, Wang L, Byrne DW, Schmidinger H. Multiple autonomic and repolarization investigation of sudden cardiac death in dilated cardiomyopathy and controls. Circ Arrhythm Electrophysiol [print-electronic]. 2014 Dec; 7(6): 1101-8. PMID: 25262115, PMCID: PMC4329912, PII: CIRCEP.114.001745, DOI: 10.1161/CIRCEP.114.001745, ISSN: 1941-3084.

Ramirez CE, Okamoto LE, Arnold AC, Gamboa A, Diedrich A, Choi L, Raj SR, Robertson D, Biaggioni I, Shibao CA. Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure. Hypertension [print-electronic]. 2014 Dec; 64(6): 1235-40. PMID: 25185131, PMCID: PMC4231172, PII: HYPERTENSIONAHA.114.04225, DOI: 10.1161/HYPERTENSIONAHA.114.04225, ISSN: 1524-4563.

Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J. Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes. Physiol Rep [electronic-print]. 2014 Nov 11/1/2014; 2(11): PMID: 25428949, PMCID: PMC4255815, PII: 2/11/e12209, DOI: 10.14814/phy2.12209, ISSN: 2051-817X.

Gamboa A, Okamoto LE, Arnold AC, Figueroa RA, Diedrich A, Raj SR, Paranjape SY, Farley G, Abumrad N, Biaggioni I. Autonomic blockade improves insulin sensitivity in obese subjects. Hypertension [print-electronic]. 2014 Oct; 64(4): 867-74. PMID: 25001269, PMCID: PMC4162826, PII: HYPERTENSIONAHA.114.03738, DOI: 10.1161/HYPERTENSIONAHA.114.03738, ISSN: 1524-4563.

Figueroa RA, Arnold AC, Nwazue VC, Okamoto LE, Paranjape SY, Black BK, Diedrich A, Robertson D, Biaggioni I, Raj SR, Gamboa A. Acute volume loading and exercise capacity in postural tachycardia syndrome. J. Appl. Physiol [print-electronic]. 2014 Sep 9/15/2014; 117(6): 663-8. PMID: 25059240, PMCID: PMC4157162, PII: japplphysiol.00367.2014, DOI: 10.1152/japplphysiol.00367.2014, ISSN: 1522-1601.

Mai TH, Wu J, Diedrich A, Garland EM, Robertson D. Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure. J Am Soc Hypertens [print-electronic]. 2014 May; 8(5): 286-96. PMID: 24746612, PMCID: PMC4072204, PII: S1933-1711(14)00093-X, DOI: 10.1016/j.jash.2014.03.001, ISSN: 1878-7436.

Arnold AC, Ramirez CE, Choi L, Okamoto LE, Gamboa A, Diedrich A, Raj SR, Robertson D, Biaggioni I, Shibao CA. Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure. Front Physiol. 2014; 5: 270. PMID: 25104940, PMCID: PMC4109567, DOI: 10.3389/fphys.2014.00270, ISSN: 1664-042X.

Nwazue VC, Paranjape SY, Black BK, Biaggioni I, Diedrich A, Dupont WD, Robertson D, Raj SR. Postural tachycardia syndrome and inappropriate sinus tachycardia: role of autonomic modulation and sinus node automaticity. J Am Heart Assoc. 2014; 3(2): e000700. PMID: 24721800, PMCID: PMC4187519, PII: jah3500, DOI: 10.1161/JAHA.113.000700, ISSN: 2047-9980.

Arnold AC, Okamoto LE, Diedrich A, Paranjape SY, Raj SR, Biaggioni I, Gamboa A. Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study. Neurology [print-electronic]. 2013 May 5/21/2013; 80(21): 1927-33. PMID: 23616163, PMCID: PMC3716342, PII: WNL.0b013e318293e310, DOI: 10.1212/WNL.0b013e318293e310, ISSN: 1526-632X.

Gamboa A, Okamoto LE, Raj SR, Diedrich A, Shibao CA, Robertson D, Biaggioni I. Nitric oxide and regulation of heart rate in patients with postural tachycardia syndrome and healthy subjects. Hypertension [print-electronic]. 2013 Feb; 61(2): 376-81. PMID: 23283362, PMCID: PMC3621717, PII: HYPERTENSIONAHA.111.00203, DOI: 10.1161/HYPERTENSIONAHA.111.00203, ISSN: 1524-4563.

Plash WB, Diedrich A, Biaggioni I, Garland EM, Paranjape SY, Black BK, Dupont WD, Raj SR. Diagnosing postural tachycardia syndrome: comparison of tilt testing compared with standing haemodynamics. Clin. Sci. 2013 Jan; 124(2): 109-14. PMID: 22931296, PMCID: PMC3478101, PII: CS20120276, DOI: 10.1042/CS20120276, ISSN: 1470-8736.

Gamboa A, Okamoto LE, Diedrich A, Choi L, Robertson D, Farley G, Paranjape S, Biaggioni I. Sympathetic activation and nitric oxide function in early hypertension. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2012 Apr 4/1/2012; 302(7): H1438-43. PMID: 22287587, PMCID: PMC3330790, PII: ajpheart.01020.2011, DOI: 10.1152/ajpheart.01020.2011, ISSN: 1522-1539.

Okamoto LE, Shibao C, Gamboa A, Choi L, Diedrich A, Raj SR, Black BK, Robertson D, Biaggioni I. Synergistic effect of norepinephrine transporter blockade and a-2 antagonism on blood pressure in autonomic failure. Hypertension [print-electronic]. 2012 Mar; 59(3): 650-6. PMID: 22311903, PMCID: PMC3312003, PII: HYPERTENSIONAHA.111.184812, DOI: 10.1161/HYPERTENSIONAHA.111.184812, ISSN: 1524-4563.

Mustafa HI, Raj SR, Diedrich A, Black BK, Paranjape SY, Dupont WD, Williams GH, Biaggioni I, Robertson D. Altered systemic hemodynamic and baroreflex response to angiotensin II in postural tachycardia syndrome. Circ Arrhythm Electrophysiol [print-electronic]. 2012 Feb; 5(1): 173-80. PMID: 22247480, PMCID: PMC3577936, PII: CIRCEP.111.965343, DOI: 10.1161/CIRCEP.111.965343, ISSN: 1941-3084.

Okamoto LE, Raj SR, Peltier A, Gamboa A, Shibao C, Diedrich A, Black BK, Robertson D, Biaggioni I. Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes. Clin. Sci. 2012 Feb; 122(4): 183-92. PMID: 21906029, PMCID: PMC3203411, PII: CS20110200, DOI: 10.1042/CS20110200, ISSN: 1470-8736.

Peltier AC, Bagai K, Artibee K, Diedrich A, Garland E, Elasy T, Shi Y, Wang L, Feldman EL, Robertson D, Malow BA. Effect of mild hyperglycemia on autonomic function in obstructive sleep apnea. Clin. Auton. Res [print-electronic]. 2012 Feb; 22(1): 1-8. PMID: 21796355, PMCID: PMC3925507, DOI: 10.1007/s10286-011-0131-9, ISSN: 1619-1560.

Mustafa HI, Fessel JP, Barwise J, Shannon JR, Raj SR, Diedrich A, Biaggioni I, Robertson D. Dysautonomia: perioperative implications. Anesthesiology. 2012 Jan; 116(1): 205-15. PMID: 22143168, PMCID: PMC3296831, DOI: 10.1097/ALN.0b013e31823db712, ISSN: 1528-1175.

English BA, Appalsamy M, Diedrich A, Ruggiero AM, Lund D, Wright J, Keller NR, Louderback KM, Robertson D, Blakely RD. Tachycardia, reduced vagal capacity, and age-dependent ventricular dysfunction arising from diminished expression of the presynaptic choline transporter. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2010 Sep; 299(3): H799-810. PMID: 20601463, PMCID: PMC2944482, PII: ajpheart.00170.2010, DOI: 10.1152/ajpheart.00170.2010, ISSN: 1522-1539.

McHugh J, Keller NR, Appalsamy M, Thomas SA, Raj SR, Diedrich A, Biaggioni I, Jordan J, Robertson D. Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control. Hypertension [print-electronic]. 2010 Jun; 55(6): 1438-43. PMID: 20385965, PMCID: PMC2965336, PII: HYPERTENSIONAHA.110.151860, DOI: 10.1161/HYPERTENSIONAHA.110.151860, ISSN: 1524-4563.

Peltier AC, Garland E, Raj SR, Sato K, Black B, Song Y, Wang L, Biaggioni I, Diedrich A, Robertson D. Distal sudomotor findings in postural tachycardia syndrome. Clin. Auton. Res [print-electronic]. 2010 Apr; 20(2): 93-9. PMID: 20035362, PMCID: PMC3089763, DOI: 10.1007/s10286-009-0045-y, ISSN: 1619-1560.

Puzanovova M, Arbogast PG, Smith CA, Anderson J, Diedrich A, Walker LS. Autonomic activity and somatic symptoms in response to success vs. failure on a cognitive task: a comparison of chronic abdominal pain patients and well children. J Psychosom Res [print-electronic]. 2009 Sep; 67(3): 235-43. PMID: 19686879, PMCID: PMC2748677, PII: S0022-3999(09)00080-4, DOI: 10.1016/j.jpsychores.2009.02.007, ISSN: 1879-1360.

Diedrich A, Porta A, Barbic F, Brychta RJ, Bonizzi P, Diedrich L, Cerutti S, Robertson D, Furlan R. Lateralization of expression of neural sympathetic activity to the vessels and effects of carotid baroreceptor stimulation. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2009 Jun; 296(6): H1758-65. PMID: 19363133, PMCID: PMC2716107, PII: 01045.2008, DOI: 10.1152/ajpheart.01045.2008, ISSN: 0363-6135.

Okamoto LE, Gamboa A, Shibao C, Black BK, Diedrich A, Raj SR, Robertson D, Biaggioni I. Nocturnal blood pressure dipping in the hypertension of autonomic failure. Hypertension [print-electronic]. 2009 Feb; 53(2): 363-9. PMID: 19047577, PMCID: PMC2665259, PII: HYPERTENSIONAHA.108.124552, DOI: 10.1161/HYPERTENSIONAHA.108.124552, ISSN: 1524-4563.

Goncalves AC, Tank J, Diedrich A, Hilzendeger A, Plehm R, Bader M, Luft FC, Jordan J, Gross V. Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction. Hypertension [print-electronic]. 2009 Feb; 53(2): 387-92. PMID: 19029483, PII: HYPERTENSIONAHA.108.124776, DOI: 10.1161/HYPERTENSIONAHA.108.124776, ISSN: 1524-4563.

Schroeder C, Heusser K, Tank J, Diedrich A, Luft FC, Jordan J. The Valsalva maneuver: screening for drug-induced baroreflex dysfunction. Clin. Auton. Res [print-electronic]. 2009 Feb; 19(1): 32-8. PMID: 19011931, DOI: 10.1007/s10286-008-0508-6, ISSN: 1619-1560.

Tank J, Heusser K, Diedrich A, Hering D, Luft FC, Busjahn A, Narkiewicz K, Jordan J. Influences of gender on the interaction between sympathetic nerve traffic and central adiposity. J. Clin. Endocrinol. Metab [print-electronic]. 2008 Dec; 93(12): 4974-8. PMID: 18782878, PII: jc.2007-2820, DOI: 10.1210/jc.2007-2820, ISSN: 0021-972X.

da Costa-Goncalves AC, Tank J, Plehm R, Diedrich A, Todiras M, Gollasch M, Heuser A, Wellner M, Bader M, Jordan J, Luft FC, Gross V. Role of the multidomain protein spinophilin in blood pressure and cardiac function regulation. Hypertension [print-electronic]. 2008 Oct; 52(4): 702-7. PMID: 18711009, PII: HYPERTENSIONAHA.108.114355, DOI: 10.1161/HYPERTENSIONAHA.108.114355, ISSN: 1524-4563.

Chung OY, Bruehl S, Diedrich L, Diedrich A. The impact of blood pressure and baroreflex sensitivity on wind-up. Anesth. Analg. 2008 Sep; 107(3): 1018-25. PMID: 18713923, PII: 107/3/1018, DOI: 10.1213/ane.0b013e31817f8dfe, ISSN: 1526-7598.

Chung OY, Bruehl S, Diedrich L, Diedrich A, Chont M, Robertson D. Baroreflex sensitivity associated hypoalgesia in healthy states is altered by chronic pain. Pain [print-electronic]. 2008 Aug 8/15/2008; 138(1): 87-97. PMID: 18164819, PII: S0304-3959(07)00688-4, DOI: 10.1016/j.pain.2007.11.011, ISSN: 1872-6623.

Gamboa A, Shibao C, Diedrich A, Paranjape SY, Farley G, Christman B, Raj SR, Robertson D, Biaggioni I. Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure. Hypertension [print-electronic]. 2008 Jun; 51(6): 1531-6. PMID: 18426998, PMCID: PMC2497433, PII: HYPERTENSIONAHA.107.105171, DOI: 10.1161/HYPERTENSIONAHA.107.105171, ISSN: 1524-4563.

Moldovanova I, Schroeder C, Jacob G, Hiemke C, Diedrich A, Luft FC, Jordan J. Hormonal influences on cardiovascular norepinephrine transporter responses in healthy women. Hypertension [print-electronic]. 2008 Apr; 51(4): 1203-9. PMID: 18259012, PII: HYPERTENSIONAHA.107.107433, DOI: 10.1161/HYPERTENSIONAHA.107.107433, ISSN: 1524-4563.

Strempel S, Schroeder C, Hemmersbach R, Boese A, Tank J, Diedrich A, Heer M, Luft FC, Jordan J. Norepinephrine transporter inhibition alters the hemodynamic response to hypergravitation. J. Appl. Physiol [print-electronic]. 2008 Mar; 104(3): 756-60. PMID: 18187607, PII: 01128.2007, DOI: 10.1152/japplphysiol.01128.2007, ISSN: 8750-7587.

Gross V, Tank J, Partke HJ, Plehm R, Diedrich A, da Costa Goncalves AC, Luft FC, Jordan J. Cardiovascular autonomic regulation in Non-Obese Diabetic (NOD) mice. Auton Neurosci [print-electronic]. 2008 Feb 2/29/2008; 138(1-2): 108-13. PMID: 18166503, PII: S1566-0702(07)00543-7, DOI: 10.1016/j.autneu.2007.11.006, ISSN: 1566-0702.

Bruehl S, Chung OY, Diedrich L, Diedrich A, Robertson D. The relationship between resting blood pressure and acute pain sensitivity: effects of chronic pain and alpha-2 adrenergic blockade. J Behav Med [print-electronic]. 2008 Feb; 31(1): 71-80. PMID: 17940860, DOI: 10.1007/s10865-007-9133-4, ISSN: 1573-3521.

Dujic Z, Ivancev V, Heusser K, Dzamonja G, Palada I, Valic Z, Tank J, Obad A, Bakovic D, Diedrich A, Joyner MJ, Jordan J. Central chemoreflex sensitivity and sympathetic neural outflow in elite breath-hold divers. J. Appl. Physiol [print-electronic]. 2008 Jan; 104(1): 205-11. PMID: 17991789, PII: 00844.2007, DOI: 10.1152/japplphysiol.00844.2007, ISSN: 8750-7587.

Tank J, Heusser K, Diedrich A, Brychta RJ, Luft FC, Jordan J. Yohimbine attenuates baroreflex-mediated bradycardia in humans. Hypertension [print-electronic]. 2007 Nov; 50(5): 899-903. PMID: 17875819, PII: HYPERTENSIONAHA.107.095984, DOI: 10.1161/HYPERTENSIONAHA.107.095984, ISSN: 1524-4563.

Hercule HC, Tank J, Plehm R, Wellner M, da Costa Goncalves AC, Gollasch M, Diedrich A, Jordan J, Luft FC, Gross V. Regulator of G protein signalling 2 ameliorates angiotensin II-induced hypertension in mice. Exp. Physiol [print-electronic]. 2007 Nov; 92(6): 1014-22. PMID: 17644703, PII: expphysiol.2007.038240, DOI: 10.1113/expphysiol.2007.038240, ISSN: 0958-0670.

Tank J, Obst M, Diedrich A, Brychta RJ, Blumer KJ, Heusser K, Jordan J, Luft FC, Gross V. Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice. Auton Neurosci [print-electronic]. 2007 Oct 10/30/2007; 136(1-2): 52-7. PMID: 17507294, PII: S1566-0702(07)00104-X, DOI: 10.1016/j.autneu.2007.04.001, ISSN: 1566-0702.

Diedrich A, Paranjape SY, Robertson D. Plasma and blood volume in space. Am. J. Med. Sci. 2007 Jul; 334(1): 80-5. PMID: 17630598, PII: 00000441-200707000-00024, DOI: 10.1097/MAJ.0b013e318065b89b, ISSN: 0002-9629.

Ertl AC, Diedrich A, Raj SR. Techniques used for the determination of blood volume. Am. J. Med. Sci. 2007 Jul; 334(1): 32-6. PMID: 17630589, PII: 00000441-200707000-00015, DOI: 10.1097/MAJ.0b013e318063c6d1, ISSN: 0002-9629.

Shibao C, Raj SR, Gamboa A, Diedrich A, Choi L, Black BK, Robertson D, Biaggioni I. Norepinephrine transporter blockade with atomoxetine induces hypertension in patients with impaired autonomic function. Hypertension [print-electronic]. 2007 Jul; 50(1): 47-53. PMID: 17515448, PII: HYPERTENSIONAHA.107.089961, DOI: 10.1161/HYPERTENSIONAHA.107.089961, ISSN: 1524-4563.

Shibao C, Gamboa A, Diedrich A, Dossett C, Choi L, Farley G, Biaggioni I. Acarbose, an alpha-glucosidase inhibitor, attenuates postprandial hypotension in autonomic failure. Hypertension [print-electronic]. 2007 Jul; 50(1): 54-61. PMID: 17515447, PII: HYPERTENSIONAHA.107.091355, DOI: 10.1161/HYPERTENSIONAHA.107.091355, ISSN: 1524-4563.

Baevsky RM, Baranov VM, Funtova II, Diedrich A, Pashenko AV, Chernikova AG, Drescher J, Jordan J, Tank J. Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station. J. Appl. Physiol [print-electronic]. 2007 Jul; 103(1): 156-61. PMID: 17446414, PII: 00137.2007, DOI: 10.1152/japplphysiol.00137.2007, ISSN: 8750-7587.

Diedrich A, Malow BA, Antic NA, Sato K, McEvoy RD, Mathias CJ, Robertson D, Berry-Kravis EM, Weese-Mayer DE. Vagal and sympathetic heart rate and blood pressure control in adult onset PHOX2B mutation-confirmed congenital central hypoventilation syndrome. Clin. Auton. Res [print-electronic]. 2007 Jun; 17(3): 177-85. PMID: 17541758, DOI: 10.1007/s10286-007-0421-4, ISSN: 0959-9851.

Dzurik MV, Diedrich A, Black B, Paranjape SY, Raj SR, Byrne DW, Robertson D. Endogenous substance P modulates human cardiovascular regulation at rest and during orthostatic load. J. Appl. Physiol [print-electronic]. 2007 Jun; 102(6): 2092-7. PMID: 17255371, PII: 00969.2006, DOI: 10.1152/japplphysiol.00969.2006, ISSN: 8750-7587.

Raj SR, Robertson D, Biaggioni I, Diedrich A. Abnormal valsalva maneuver is not always a sign of congestive heart failure [letter]. Am. J. Med. 2007 Jun; 120(6): e15-6. PMID: 17524733, PII: S0002-9343(06)00392-5, DOI: 10.1016/j.amjmed.2006.03.022, ISSN: 1555-7162.

Kurnik D, Muszkat M, Friedman EA, Sofowora GG, Diedrich A, Xie HG, Harris PA, Choi L, Wood AJ, Stein CM. Effect of the alpha2C-adrenoreceptor deletion322-325 variant on sympathetic activity and cardiovascular measures in healthy subjects. J. Hypertens. 2007 Apr; 25(4): 763-71. PMID: 17351367, PII: 00004872-200704000-00006, DOI: 10.1097/HJH.0b013e328017f6e9, ISSN: 0263-6352.

Gamboa A, Diedrich A, Biaggioni I. Pharmacological probes to measure the importance of the autonomic nervous system [editorial]. Clin. Auton. Res. 2007 Apr; 17(2): 65-8. PMID: 17401762, DOI: 10.1007/s10286-007-0406-3, ISSN: 0959-9851.

Heusser K, Engeli S, Tank J, Diedrich A, Wiesner S, Janke J, Luft FC, Jordan J. Sympathetic vasomotor tone determines blood pressure response to long-term sibutramine treatment. J. Clin. Endocrinol. Metab [print-electronic]. 2007 Apr; 92(4): 1560-3. PMID: 17284621, PII: jc.2006-2499, DOI: 10.1210/jc.2006-2499, ISSN: 0021-972X.

Brychta RJ, Shiavi R, Robertson D, Diedrich A. Spike detection in human muscle sympathetic nerve activity using the kurtosis of stationary wavelet transform coefficients. J. Neurosci. Methods [print-electronic]. 2007 Mar 3/15/2007; 160(2): 359-67. PMID: 17083982, PMCID: PMC2075105, PII: S0165-0270(06)00473-0, DOI: 10.1016/j.jneumeth.2006.09.020, ISSN: 0165-0270.

Iwasaki K, Levine BD, Zhang R, Zuckerman JH, Pawelczyk JA, Diedrich A, Ertl AC, Cox JF, Cooke WH, Giller CA, Ray CA, Lane LD, Buckey JC, Baisch FJ, Eckberg DL, Robertson D, Biaggioni I, Blomqvist CG. Human cerebral autoregulation before, during and after spaceflight. J. Physiol. (Lond.) [print-electronic]. 2007 Mar 3/15/2007; 579(Pt 3): 799-810. PMID: 17185344, PMCID: PMC2151354, PII: jphysiol.2006.119636, DOI: 10.1113/jphysiol.2006.119636, ISSN: 0022-3751.

Brychta RJ, Shiavi R, Robertson D, Biaggioni I, Diedrich A. A simplified two-component model of blood pressure fluctuation. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2007 Feb; 292(2): H1193-203. PMID: 17012354, PMCID: PMC1987355, PII: 00645.2006, DOI: 10.1152/ajpheart.00645.2006, ISSN: 0363-6135.

Brychta RJ, Tuntrakool S, Appalsamy M, Keller NR, Robertson D, Shiavi RG, Diedrich A. Wavelet methods for spike detection in mouse renal sympathetic nerve activity. IEEE Trans Biomed Eng. 2007 Jan; 54(1): 82-93. PMID: 17260859, PMCID: PMC2075098, DOI: 10.1109/TBME.2006.883830, ISSN: 0018-9294.

Gamboa A, Shibao C, Diedrich A, Choi L, Pohar B, Jordan J, Paranjape S, Farley G, Biaggioni I. Contribution of endothelial nitric oxide to blood pressure in humans. Hypertension [print-electronic]. 2007 Jan; 49(1): 170-7. PMID: 17130304, PII: 01.HYP.0000252425.06216.26, DOI: 10.1161/01.HYP.0000252425.06216.26, ISSN: 1524-4563.

Shibao C, Gamboa A, Diedrich A, Ertl AC, Chen KY, Byrne DW, Farley G, Paranjape SY, Davis SN, Biaggioni I. Autonomic contribution to blood pressure and metabolism in obesity. Hypertension [print-electronic]. 2007 Jan; 49(1): 27-33. PMID: 17116758, PII: 01.HYP.0000251679.87348.05, DOI: 10.1161/01.HYP.0000251679.87348.05, ISSN: 1524-4563.

Birkenfeld AL, Boschmann M, Moro C, Adams F, Heusser K, Tank J, Diedrich A, Schroeder C, Franke G, Berlan M, Luft FC, Lafontan M, Jordan J. Beta-adrenergic and atrial natriuretic peptide interactions on human cardiovascular and metabolic regulation. J. Clin. Endocrinol. Metab [print-electronic]. 2006 Dec; 91(12): 5069-75. PMID: 16984990, PMCID: PMC2072963, PII: jc.2006-1084, DOI: 10.1210/jc.2006-1084, ISSN: 0021-972X.

Diedrich A, Bock HC, König F, Schulz TG, Ludwig HC, Herken R, Quondamatteo F. Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours. Histol. Histopathol. 2006 Nov; 21(11): 1199-207. PMID: 16874663, ISSN: 1699-5848.

Schroeder C, Birkenfeld AL, Mayer AF, Tank J, Diedrich A, Luft FC, Jordan J. Norepinephrine transporter inhibition prevents tilt-induced pre-syncope. J. Am. Coll. Cardiol [print-electronic]. 2006 Aug 8/1/2006; 48(3): 516-22. PMID: 16875978, PII: S0735-1097(06)01250-2, DOI: 10.1016/j.jacc.2006.04.073, ISSN: 1558-3597.

Mayer AF, Schroeder C, Heusser K, Tank J, Diedrich A, Schmieder RE, Luft FC, Jordan J. Influences of norepinephrine transporter function on the distribution of sympathetic activity in humans. Hypertension [print-electronic]. 2006 Jul; 48(1): 120-6. PMID: 16717144, PII: 01.HYP.0000225424.13138.5d, DOI: 10.1161/01.HYP.0000225424.13138.5d, ISSN: 1524-4563.

Heusser K, Tank J, Diedrich A, Engeli S, Klaua S, Krüger N, Strauss A, Stoffels G, Luft FC, Jordan J. Influence of sibutramine treatment on sympathetic vasomotor tone in obese subjects. Clin. Pharmacol. Ther. 2006 May; 79(5): 500-8. PMID: 16678551, PII: S0009-9236(06)00039-7, DOI: 10.1016/j.clpt.2006.02.002, ISSN: 0009-9236.

Voustianiouk A, Kaufmann H, Diedrich A, Raphan T, Biaggioni I, Macdougall H, Ogorodnikov D, Cohen B. Electrical activation of the human vestibulo-sympathetic reflex. Exp Brain Res [print-electronic]. 2006 May; 171(2): 251-61. PMID: 16308690, DOI: 10.1007/s00221-005-0266-9, ISSN: 0014-4819.

Shibao C, Gamboa A, Diedrich A, Biaggioni I. Management of hypertension in the setting of autonomic dysfunction. Curr Treat Options Cardiovasc Med. 2006 Apr; 8(2): 105-9. PMID: 16533484, ISSN: 1092-8464.

Obst M, Tank J, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC, Gross V. NO-dependent blood pressure regulation in RGS2-deficient mice. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2006 Apr; 290(4): R1012-9. PMID: 16269576, PMCID: PMC2776685, PII: 00288.2005, DOI: 10.1152/ajpregu.00288.2005, ISSN: 0363-6119.

Shibao C, Gamboa A, Abraham R, Raj SR, Diedrich A, Black B, Robertson D, Biaggioni I. Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure. Hypertension [print-electronic]. 2006 Mar; 47(3): 522-6. PMID: 16391172, PII: 01.HYP.0000199982.71858.11, DOI: 10.1161/01.HYP.0000199982.71858.11, ISSN: 1524-4563.

Keller NR, Diedrich A, Appalsamy M, Miller LC, Caron MG, McDonald MP, Shelton RC, Blakely RD, Robertson D. Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension. Neuroscience [print-electronic]. 2006; 139(3): 931-46. PMID: 16515844, PII: S0306-4522(06)00099-6, DOI: 10.1016/j.neuroscience.2006.01.008, ISSN: 0306-4522.

Gamboa A, Abraham R, Diedrich A, Shibao C, Paranjape SY, Farley G, Biaggioni I. Role of adenosine and nitric oxide on the mechanisms of action of dipyridamole. Stroke [print-electronic]. 2005 Oct; 36(10): 2170-5. PMID: 16141426, PII: 01.STR.0000179044.37760.9d, DOI: 10.1161/01.STR.0000179044.37760.9d, ISSN: 1524-4628.

Winker R, Garland EM, Rüdiger HW, Diedrich A, Biaggioni I, Ponocny I, Cascorbi I, Robertson D. Influence of an insertion variant in the 5'UTR of the endothelin-1 gene on orthostatic intolerance. Am. J. Med. Sci. 2005 Oct; 330(4): 166-71. PMID: 16234608, PII: 00000441-200510000-00003, ISSN: 0002-9629.

Raj SR, Diedrich A, Biaggioni I. Can we diagnose, treat or even understand neurally mediated syncope?. Clin. Sci. 2005 Aug; 109(2): 161-3. PMID: 15842199, PII: CS20050122, DOI: 10.1042/CS20050122, ISSN: 0143-5221.

Jacob G, Gamboa A, Diedrich A, Shibao C, Robertson D, Biaggioni I. Tyramine-induced vasodilation mediated by dopamine contamination: a paradox resolved. Hypertension [print-electronic]. 2005 Aug; 46(2): 355-9. PMID: 15967868, PII: 01.HYP.0000172353.62657.8b, DOI: 10.1161/01.HYP.0000172353.62657.8b, ISSN: 1524-4563.

Tank J, Diedrich A, Szczech E, Luft FC, Jordan J. Baroreflex regulation of heart rate and sympathetic vasomotor tone in women and men. Hypertension [print-electronic]. 2005 Jun; 45(6): 1159-64. PMID: 15867130, PII: 01.HYP.0000165695.98915.9a, DOI: 10.1161/01.HYP.0000165695.98915.9a, ISSN: 1524-4563.

Moore ST, Diedrich A, Biaggioni I, Kaufmann H, Raphan T, Cohen B. Artificial gravity: a possible countermeasure for post-flight orthostatic intolerance. Acta Astronaut. 2005 May; 56(9-12): 867-76. PMID: 15835033, ISSN: 0094-5765.

Gross V, Tank J, Obst M, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC. Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2005 May; 288(5): R1134-42. PMID: 15661972, PII: 00246.2004, DOI: 10.1152/ajpregu.00246.2004, ISSN: 0363-6119.

Taneja I, Diedrich A, Black BK, Byrne DW, Paranjape SY, Robertson D. Modafinil elicits sympathomedullary activation. Hypertension [print-electronic]. 2005 Apr; 45(4): 612-8. PMID: 15753235, PII: 01.HYP.0000158267.66763.63, DOI: 10.1161/01.HYP.0000158267.66763.63, ISSN: 1524-4563.

Shibao C, Gamboa A, Diedrich A, Biaggioni I. Management of hypertension in the setting of autonomic failure: a pathophysiological approach. Hypertension [print-electronic]. 2005 Apr; 45(4): 469-76. PMID: 15738343, PII: 01.HYP.0000158835.94916.0c, DOI: 10.1161/01.HYP.0000158835.94916.0c, ISSN: 1524-4563.

Winker R, Barth A, Bidmon D, Ponocny I, Weber M, Mayr O, Robertson D, Diedrich A, Maier R, Pilger A, Haber P, Rüdiger HW. Endurance exercise training in orthostatic intolerance: a randomized, controlled trial. Hypertension [print-electronic]. 2005 Mar; 45(3): 391-8. PMID: 15699447, PII:, DOI: 10.1161/, ISSN: 1524-4563.

Christou DD, Jones PP, Jordan J, Diedrich A, Robertson D, Seals DR. Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation. 2005 Feb 2/1/2005; 111(4): 494-8. PMID: 15687139, PII: 111/4/494, DOI: 10.1161/01.CIR.0000153864.24034.A6, ISSN: 1524-4539.

Keller NR, Diedrich A, Appalsamy M, Tuntrakool S, Lonce S, Finney C, Caron MG, Robertson D. Norepinephrine transporter-deficient mice exhibit excessive tachycardia and elevated blood pressure with wakefulness and activity. Circulation [print-electronic]. 2004 Sep 9/7/2004; 110(10): 1191-6. PMID: 15337696, PII: 01.CIR.0000141804.90845.E6, DOI: 10.1161/01.CIR.0000141804.90845.E6, ISSN: 1524-4539.

Lucini D, Furlan R, Villa P, Mosqueda-Garcia R, Diedrich A, Robertson D, Malliani A, Porta A, Pagani M. Altered profile of baroreflex and autonomic responses to lower body negative pressure in chronic orthostatic intolerance. J. Hypertens. 2004 Aug; 22(8): 1535-42. PMID: 15257177, PII: 00004872-200408000-00019, ISSN: 0263-6352.

Diedrich A, Biaggioni I. Segmental orthostatic fluid shifts. Clin. Auton. Res. 2004 Jun; 14(3): 146-7. PMID: 15241642, DOI: 10.1007/s10286-004-0188-9, ISSN: 0959-9851.

Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft FC, Gross V. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension [print-electronic]. 2004 May; 43(5): 1042-7. PMID: 15051667, PII: 01.HYP.0000125884.49812.72, DOI: 10.1161/01.HYP.0000125884.49812.72, ISSN: 1524-4563.

Tank J, Diedrich A, Szczech E, Luft FC, Jordan J. Alpha-2 adrenergic transmission and human baroreflex regulation. Hypertension [print-electronic]. 2004 May; 43(5): 1035-41. PMID: 15037555, PII: 01.HYP.0000125729.90521.94, DOI: 10.1161/01.HYP.0000125729.90521.94, ISSN: 1524-4563.

Schroeder C, Adams F, Boschmann M, Tank J, Haertter S, Diedrich A, Biaggioni I, Luft FC, Jordan J. Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function. Am. J. Physiol. Regul. Integr. Comp. Physiol [print-electronic]. 2004 May; 286(5): R851-6. PMID: 14726430, PII: 00689.2003, DOI: 10.1152/ajpregu.00689.2003, ISSN: 0363-6119.

Jordan J, Shannon JR, Diedrich A, Black B, Robertson D, Biaggioni I. Water potentiates the pressor effect of ephedra alkaloids. Circulation [print-electronic]. 2004 Apr 4/20/2004; 109(15): 1823-5. PMID: 15066944, PII: 01.CIR.0000126283.99195.37, DOI: 10.1161/01.CIR.0000126283.99195.37, ISSN: 1524-4539.

Gamboa A, Ertl AC, Costa F, Farley G, Manier ML, Hachey DL, Diedrich A, Biaggioni I. Blockade of nucleoside transport is required for delivery of intraarterial adenosine into the interstitium: relevance to therapeutic preconditioning in humans. Circulation [print-electronic]. 2003 Nov 11/25/2003; 108(21): 2631-5. PMID: 14623808, PII: 01.CIR.0000101927.70100.41, DOI: 10.1161/01.CIR.0000101927.70100.41, ISSN: 1524-4539.

Lu CC, Diedrich A, Tung CS, Paranjape SY, Harris PA, Byrne DW, Jordan J, Robertson D. Water ingestion as prophylaxis against syncope. Circulation [print-electronic]. 2003 Nov 11/25/2003; 108(21): 2660-5. PMID: 14623807, PII: 01.CIR.0000101966.24899.CB, DOI: 10.1161/01.CIR.0000101966.24899.CB, ISSN: 1524-4539.

Tank J, Jordan J, Diedrich A, Schroeder C, Furlan R, Sharma AM, Luft FC, Brabant G. Bound leptin and sympathetic outflow in nonobese men. J. Clin. Endocrinol. Metab. 2003 Oct; 88(10): 4955-9. PMID: 14557480, DOI: 10.1210/jc.2003-030371, ISSN: 0021-972X.

Diedrich A, Jordan J, Tank J, Shannon JR, Robertson R, Luft FC, Robertson D, Biaggioni I. The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade. J. Hypertens. 2003 Sep; 21(9): 1677-86. PMID: 12923400, DOI: 10.1097/01.hjh.0000084711.87421.07, ISSN: 0263-6352.

Furlan R, Diedrich A, Rimoldi A, Palazzolo L, Porta C, Diedrich L, Harris PA, Sleight P, Biagioni I, Robertson D, Bernardi L. Effects of unilateral and bilateral carotid baroreflex stimulation on cardiac and neural sympathetic discharge oscillatory patterns. Circulation [print-electronic]. 2003 Aug 8/12/2003; 108(6): 717-23. PMID: 12900347, PII: 01.CIR.0000084540.91605.0C, DOI: 10.1161/01.CIR.0000084540.91605.0C, ISSN: 1524-4539.

Tank J, Diedrich A, Hale N, Niaz FE, Furlan R, Robertson RM, Mosqueda-Garcia R. Relationship between blood pressure, sleep K-complexes, and muscle sympathetic nerve activity in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003 Jul; 285(1): R208-14. PMID: 12793998, PII: 285/1/R208, DOI: 10.1152/ajpregu.00013.2003, ISSN: 0363-6119.

Tank J, Schroeder C, Diedrich A, Szczech E, Haertter S, Sharma AM, Luft FC, Jordan J. Selective impairment in sympathetic vasomotor control with norepinephrine transporter inhibition. Circulation [print-electronic]. 2003 Jun 6/17/2003; 107(23): 2949-54. PMID: 12796139, PII: 01.CIR.0000072786.99163.FE, DOI: 10.1161/01.CIR.0000072786.99163.FE, ISSN: 1524-4539.

Tank J, Schroeder C, Stoffels M, Diedrich A, Sharma AM, Luft FC, Jordan J. Pressor effect of water drinking in tetraplegic patients may be a spinal reflex. Hypertension [print-electronic]. 2003 Jun; 41(6): 1234-9. PMID: 12719442, PII: 01.HYP.0000070957.08219.C9, DOI: 10.1161/01.HYP.0000070957.08219.C9, ISSN: 1524-4563.

Diedrich A, Charoensuk W, Brychta RJ, Ertl AC, Shiavi R. Analysis of raw microneurographic recordings based on wavelet de-noising technique and classification algorithm: wavelet analysis in microneurography. IEEE Trans Biomed Eng. 2003 Jan; 50(1): 41-50. PMID: 12617523, DOI: 10.1109/TBME.2002.807323, ISSN: 0018-9294.

Carson RP, Diedrich A, Robertson D. Autonomic control after blockade of the norepinephrine transporter: a model of orthostatic intolerance. J. Appl. Physiol [print-electronic]. 2002 Dec; 93(6): 2192-8. PMID: 12391111, PII: 00033.2002, DOI: 10.1152/japplphysiol.00033.2002, ISSN: 8750-7587.

Diedrich A, Jordan J, Shannon JR, Robertson D, Biaggioni I. Modulation of QT interval during autonomic nervous system blockade in humans. Circulation. 2002 Oct 10/22/2002; 106(17): 2238-43. PMID: 12390954, ISSN: 1524-4539.

Fu Q, Levine BD, Pawelczyk JA, Ertl AC, Diedrich A, Cox JF, Zuckerman JH, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC, Cooke WH, Robertson RM, Baisch FJ, Blomqvist CG, Eckberg DL, Robertson D, Biaggioni I. Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight. J. Physiol. (Lond.). 2002 Oct 10/15/2002; 544(Pt 2): 653-64. PMID: 12381834, PMCID: PMC2290607, PII: PHY_025098, ISSN: 0022-3751.

Parikh SM, Diedrich A, Biaggioni I, Robertson D. The nature of the autonomic dysfunction in multiple system atrophy. J. Neurol. Sci. 2002 Aug 8/15/2002; 200(1-2): 1-10. PMID: 12127669, PII: S0022510X02001260, ISSN: 0022-510X.

Gross V, Plehm R, Tank J, Jordan J, Diedrich A, Obst M, Luft FC. Heart rate variability and baroreflex function in AT2 receptor-disrupted mice. Hypertension. 2002 Aug; 40(2): 207-13. PMID: 12154115, ISSN: 1524-4563.

Jordan J, Lipp A, Tank J, Schröder C, Stoffels M, Franke G, Diedrich A, Arnold G, Goldstein DS, Sharma AM, Luft FC. Catechol-o-methyltransferase and blood pressure in humans. Circulation. 2002 Jul 7/23/2002; 106(4): 460-5. PMID: 12135946, ISSN: 1524-4539.

Shannon JR, Diedrich A, Biaggioni I, Tank J, Robertson RM, Robertson D, Jordan J. Water drinking as a treatment for orthostatic syndromes. Am. J. Med. 2002 Apr 4/1/2002; 112(5): 355-60. PMID: 11904109, PII: S0002934302010252, ISSN: 0002-9343.

Kaufmann H, Biaggioni I, Voustianiouk A, Diedrich A, Costa F, Clarke R, Gizzi M, Raphan T, Cohen B. Vestibular control of sympathetic activity. An otolith-sympathetic reflex in humans. Exp Brain Res [print-electronic]. 2002 Apr; 143(4): 463-9. PMID: 11914792, DOI: 10.1007/s00221-002-1002-3, ISSN: 0014-4819.

Jordan J, Tank J, Shannon JR, Diedrich A, Lipp A, Schröder C, Arnold G, Sharma AM, Biaggioni I, Robertson D, Luft FC. Baroreflex buffering and susceptibility to vasoactive drugs. Circulation. 2002 Mar 3/26/2002; 105(12): 1459-64. PMID: 11914255, ISSN: 1524-4539.

Schroeder C, Tank J, Boschmann M, Diedrich A, Sharma AM, Biaggioni I, Luft FC, Jordan J. Selective norepinephrine reuptake inhibition as a human model of orthostatic intolerance. Circulation. 2002 Jan 1/22/2002; 105(3): 347-53. PMID: 11804991, ISSN: 1524-4539.

Ertl AC, Diedrich A, Biaggioni I, Levine BD, Robertson RM, Cox JF, Zuckerman JH, Pawelczyk JA, Ray CA, Buckey JC, Lane LD, Shiavi R, Gaffney FA, Costa F, Holt C, Blomqvist CG, Eckberg DL, Baisch FJ, Robertson D. Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space. J. Physiol. (Lond.). 2002 Jan 1/1/2002; 538(Pt 1): 321-9. PMID: 11773339, PMCID: PMC2290013, PII: PHY_12576, ISSN: 0022-3751.

Jordan J, Shannon JR, Diedrich A, Black BK, Robertson D. Increased sympathetic activation in idiopathic orthostatic intolerance: role of systemic adrenoreceptor sensitivity. Hypertension. 2002 Jan; 39(1): 173-8. PMID: 11799098, ISSN: 1524-4563.

Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A, Biaggioni I, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC, Cooke WH, Baisch FJ, Eckberg DL, Blomqvist CG. Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight. J. Physiol. (Lond.). 2002 Jan 1/1/2002; 538(Pt 1): 331-40. PMID: 11773340, PMCID: PMC2290017, PII: PHY_12575, ISSN: 0022-3751.

Cox JF, Tahvanainen KU, Kuusela TA, Levine BD, Cooke WH, Mano T, Iwase S, Saito M, Sugiyama Y, Ertl AC, Biaggioni I, Diedrich A, Robertson RM, Zuckerman JH, Lane LD, Ray CA, White RJ, Pawelczyk JA, Buckey JC, Baisch FJ, Blomqvist CG, Robertson D, Eckberg DL. Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre. J. Physiol. (Lond.). 2002 Jan 1/1/2002; 538(Pt 1): 309-20. PMID: 11773338, PMCID: PMC2290008, PII: PHY_12574, ISSN: 0022-3751.

Furlan R, Jacob G, Palazzolo L, Rimoldi A, Diedrich A, Harris PA, Porta A, Malliani A, Mosqueda-Garcia R, Robertson D. Sequential modulation of cardiac autonomic control induced by cardiopulmonary and arterial baroreflex mechanisms. Circulation. 2001 Dec 12/11/2001; 104(24): 2932-7. PMID: 11739308, ISSN: 1524-4539.

Tank J, Diedrich A, Schroeder C, Stoffels M, Franke G, Sharma AM, Luft FC, Jordan J. Limited effect of systemic beta-blockade on sympathetic outflow. Hypertension. 2001 Dec 12/1/2001; 38(6): 1377-81. PMID: 11751721, ISSN: 1524-4563.

Tank J, Toka O, Toka HR, Jordan J, Diedrich A, Busjahn A, Luft FC. Autonomic nervous system function in patients with monogenic hypertension and brachydactyly: a field study in north-eastern Turkey. J Hum Hypertens. 2001 Nov; 15(11): 787-92. PMID: 11687923, DOI: 10.1038/sj.jhh.1001271, ISSN: 0950-9240.

Robertson D, Shannon JR, Jordan J, Davis TL, Diedrich A, Jacob G, Garland E, Tellioglu T, Biaggioni I. Multiple system atrophy: new developments in pathophysiology and therapy. Parkinsonism Relat. Disord. 2001 Jul; 7(3): 257-60. PMID: 11331196, PII: S1353-8020(00)00067-5, ISSN: 1873-5126.

Carson RP, Appalsamy M, Diedrich A, Davis TL, Robertson D. Animal model of neuropathic tachycardia syndrome. Hypertension. 2001 Jun; 37(6): 1357-61. PMID: 11408377, ISSN: 1524-4563.

Costa F, Diedrich A, Johnson B, Sulur P, Farley G, Biaggioni I. Adenosine, a metabolic trigger of the exercise pressor reflex in humans. Hypertension. 2001 Mar; 37(3): 917-22. PMID: 11244018, ISSN: 1524-4563.

Tank J, Jordan J, Diedrich A, Stoffels M, Franke G, Faulhaber HD, Luft FC, Busjahn A. Genetic influences on baroreflex function in normal twins. Hypertension. 2001 Mar; 37(3): 907-10. PMID: 11244016, ISSN: 1524-4563.

Jordan J, Tank J, Diedrich A, Robertson D, Shannon JR. Vasopressin and blood pressure in humans [letter]. Hypertension. 2000 Dec; 36(6): E3-4. PMID: 11116134, ISSN: 1524-4563.

Jordan J, Toka HR, Heusser K, Toka O, Shannon JR, Tank J, Diedrich A, Stabroth C, Stoffels M, Naraghi R, Oelkers W, Schuster H, Schobel HP, Haller H, Luft FC. Severely impaired baroreflex-buffering in patients with monogenic hypertension and neurovascular contact. Circulation. 2000 Nov 11/21/2000; 102(21): 2611-8. PMID: 11085965, ISSN: 1524-4539.

Ertl AC, Diedrich A, Biaggioni I. Baroreflex dysfunction induced by microgravity: potential relevance to postflight orthostatic intolerance. Clin. Auton. Res. 2000 Oct; 10(5): 269-77. PMID: 11198482, ISSN: 0959-9851.

Jordan J, Shannon JR, Diedrich A, Black B, Costa F, Robertson D, Biaggioni I. Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans. Hypertension. 2000 Sep; 36(3): 383-8. PMID: 10988269, ISSN: 1524-4563.

Shannon JR, Jordan J, Diedrich A, Pohar B, Black BK, Robertson D, Biaggioni I. Sympathetically mediated hypertension in autonomic failure. Circulation. 2000 Jun 6/13/2000; 101(23): 2710-5. PMID: 10851208, ISSN: 1524-4539.

Asconapé J, Diedrich A, DellaBadia J. Myoclonus associated with the use of gabapentin. Epilepsia. 2000 Apr; 41(4): 479-81. PMID: 10756416, ISSN: 0013-9580.

Jordan J, Shannon JR, Black BK, Ali Y, Farley M, Costa F, Diedrich A, Robertson RM, Biaggioni I, Robertson D. The pressor response to water drinking in humans : a sympathetic reflex?. Circulation. 2000 Feb 2/8/2000; 101(5): 504-9. PMID: 10662747, ISSN: 1524-4539.

Robertson D, Shannon JR, Biaggioni I, Ertl AC, Diedrich A, Carson R, Furlan R, Jacob G, Jordan J, . Orthostatic intolerance and the postural tachycardia syndrome: genetic and environment pathophysiologies. Neurolab Autonomic Team. Pflugers Arch. 2000; 441(2-3 Suppl): R48-51. PMID: 11200979, ISSN: 0031-6768.

Robertson D, Biaggioni I, Ertl AC, Robertson RM, Diedrich A, Blakely RD, Flattem N, Shannon JR. Orthostatic intolerance: emerging genetic and environmental etiologies. J Gravit Physiol. 1999 Jul; 6(1): P51-4. PMID: 11543025, ISSN: 1077-9248.

Cooke WH, Cox JF, Diedrich AM, Taylor JA, Beightol LA, Ames JE, Hoag JB, Seidel H, Eckberg DL. Controlled breathing protocols probe human autonomic cardiovascular rhythms. Am. J. Physiol. 1998 Feb; 274(2 Pt 2): H709-18. PMID: 9486278, ISSN: 0002-9513.

Morillo CA, Eckberg DL, Ellenbogen KA, Beightol LA, Hoag JB, Tahvanainen KU, Kuusela TA, Diedrich AM. Vagal and sympathetic mechanisms in patients with orthostatic vasovagal syncope. Circulation. 1997 Oct 10/21/1997; 96(8): 2509-13. PMID: 9355886, ISSN: 0009-7322.

Samel A, Diedrich A, Drescher J, Lorenz B, Plath G, Vejvoda M, Wenzel J. [Long-term monitoring of psychophysiologic values in flight physiology]. Internist (Berl). 1997 Aug; 38(8): 755-69. PMID: 9378622, ISSN: 0020-9554.

Diedrich A, Drescher J, Nalishitij V, Spatenko JA, Rome JL, Grüber W. Heart rate variability during head down tilt and lower body negative pressure in the Russian Tschibis. J Gravit Physiol. 1995; 2(1): P13-4. PMID: 11538895, ISSN: 1077-9248.

Drescher J, Diedrich A, Lebedev AN, Spatenko JA, Rome JL, Grüber W. Forehead skin microcirculation during tilt table testing and lower body negative pressure. J Gravit Physiol. 1995; 2(1): P11-2. PMID: 11538887, ISSN: 1077-9248.

Diedrich A, Drescher J, Nalishitj V, Kirchner F. Acute effects of simulated microgravity on heart rate variability. J Gravit Physiol. 1994 May; 1(1): P35-6. PMID: 11538755, ISSN: 1077-9248.