Ariel Y. Deutch, Ph.D.

Faculty Appointments
Professor of Psychiatry and Behavioral Sciences Professor of PharmacologyJames G. Blakemore Chair in Psychiatry and Behavioral Sciences
Ph.D., Psychology, University of Georgia, Athens, GeorgiaB.A., Psychology, Vanderbilt University, Nashville, Tennessee
Research Description
Central dopamine (DA) systems are critically involved in a number of neuropsychiatric disorders, including schizophrenia and Parkinson's disease. Our lab focuses on the studies of the DA innervations of prefrontal cortex and striatal complex, using a number of anatomical, biochemical and molecular approaches.

Studies on the prefrontal cortical DA innervation seek to delineate the anatomical organization of the projections and to define the mechanisms through which alterations in cortical DA systems transsynaptically regulate subcortical systems. The latter studies involve two broad experimental strategies: biochemical studies aimed at characterizing the regulation of GABAergic interneurons in the cortex by DA, and examination of the regulatory changes induced in subcortical DA systems by selective destruction of the cortical DA innervations. A major effort is devoted to understanding how antipsychotic drugs, particularly atypical antipsychotic drugs, elicit their therapeutic and side effects.

Studies of the DA innervation of the striatum aim to understand the progressive nature of Parkinson's disease, particularly changes in dendritic spines of neurons that receive convergent dopaminergic and glutamatergic inputs. To this end we use both structural and biochemical measures to study the plasticity of dendritic spines following striatal dopamine depletion.

A third set of studies explores the mechanisms of action of hallucinogens and their ability to alter thalamocortical and corticothalamic signaling. We are particularly interested in dissociating event initiating at the thalamus or cortex determining if ability of hallucinogens to activate the cortex.
Research Keywords
Dopamine and its role in Neuropsychiatric Disorders
Murphy MJM, Deutch AY. Organization of afferents to the orbitofrontal cortex in the rat. J. Comp. Neurol [print-electronic]. 2018 Jun 6/15/2018; 526(9): 1498-526. PMID: 29524205, PMCID: PMC5899655, DOI: 10.1002/cne.24424, ISSN: 1096-9861.

Mallya AP, Wang HD, Lee HNR, Deutch AY. Microglial Pruning of Synapses in the Prefrontal Cortex During Adolescence. Cereb. Cortex [print-electronic]. 2018 Apr 4/13/2018; PMID: 29668872, PII: 4969841, DOI: 10.1093/cercor/bhy061, ISSN: 1460-2199.

Stark AJ, Smith CT, Petersen KJ, Trujillo P, van Wouwe NC, Donahue MJ, Kessler RM, Deutch AY, Zald DH, Claassen DO. [18F]fallypride characterization of striatal and extrastriatal D2/3 receptors in Parkinson's disease. Neuroimage Clin. 2018; 18: 433-42. PMID: 29541577, PMCID: PMC5849871, PII: S2213-1582(18)30044-5, DOI: 10.1016/j.nicl.2018.02.010, ISSN: 2213-1582.

Deutch AY. Liraglutide for the Treatment of Antipsychotic Drug-Induced Weight Gain. JAMA Psychiatry. 2017 Nov 11/1/2017; 74(11): 1172-3. PMID: 28973118, PII: 2653440, DOI: 10.1001/jamapsychiatry.2017.3053, ISSN: 2168-6238.

Verbeeck N, Spraggins JM, Murphy MJM, Wang HD, Deutch AY, Caprioli RM, Van de Plas R. Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis. Biochim. Biophys. Acta [print-electronic]. 2017 Jul; 1865(7): 967-77. PMID: 28254588, PII: S1570-9639(17)30040-7, DOI: 10.1016/j.bbapap.2017.02.016, ISSN: 0006-3002.

Verbeeck N, Spraggins JM, Wang H-D, Murphy MJM, Deutch AY, Caprioli RM, Van de Plas R. Connecting imaging mass spectrometry and magnetic resonance imaging-based anatomical atlases for automated anatomical interpretation and differential analysis. Biochim Biophys Acta. 2017; 1865: 967-77.

Deutch AY. Extending Corticostriatal Systems. JAMA Psychiatry [print-electronic]. 2016 Jun 6/29/2016; PMID: 27367649, PII: 2529150, DOI: 10.1001/jamapsychiatry.2016.0242, ISSN: 2168-6238.

White MG, Cody PA, Bubser M, Wang HD, Deutch AY, Mathur BN. Cortical hierarchy governs rat claustrocortical circuit organization. J. Comp. Neurol [print-electronic]. 2016 Jan 1/23/2016; PMID: 26801010, PMCID: PMC4958609, DOI: 10.1002/cne.23970, ISSN: 1096-9861.

Mingote S, Chuhma N, Kusnoor SV, Field B, Deutch AY, Rayport S. Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions. J. Neurosci. 2015 Dec 12/9/2015; 35(49): 16259-71. PMID: 26658874, PMCID: PMC4682788, PII: 35/49/16259, DOI: 10.1523/JNEUROSCI.1674-15.2015, ISSN: 1529-2401.

Deutch AY, Mathur BN. Editorial: The Claustrum: charting a way forward for the brain's most mysterious nucleus. Front Syst Neurosci. 2015; 9: 103. PMID: 26236204, PMCID: PMC4502348, DOI: 10.3389/fnsys.2015.00103, ISSN: 1662-5137.

Kraemer BR, Snow JP, Vollbrecht P, Pathak A, Valentine WM, Deutch AY, Carter BD. A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress. J. Biol. Chem [print-electronic]. 2014 Aug 8/1/2014; 289(31): 21205-16. PMID: 24939843, PMCID: PMC4118083, PII: M114.563403, DOI: 10.1074/jbc.M114.563403, ISSN: 1083-351X.

Vollbrecht PJ, Simmler LD, Blakely RD, Deutch AY. Dopamine denervation of the prefrontal cortex increases expression of the astrocytic glutamate transporter GLT-1. J. Neurochem [print-electronic]. 2014 Jul; 130(1): 109-14. PMID: 24611756, PMCID: PMC4065617, DOI: 10.1111/jnc.12697, ISSN: 1471-4159.

Byun NE, Grannan M, Bubser M, Barry RL, Thompson A, Rosanelli J, Gowrishankar R, Kelm ND, Damon S, Bridges TM, Melancon BJ, Tarr JC, Brogan JT, Avison MJ, Deutch AY, Wess J, Wood MR, Lindsley CW, Gore JC, Conn PJ, Jones CK. Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100. Neuropsychopharmacology [print-electronic]. 2014 Jun; 39(7): 1578-93. PMID: 24442096, PMCID: PMC4023154, PII: npp20142, DOI: 10.1038/npp.2014.2, ISSN: 1740-634X.

Deutch AY. The thorny problem of dyskinesias: dendritic spines, synaptic plasticity, and striatal dysfunction. Biol. Psychiatry. 2014 May 5/1/2014; 75(9): 676-7. PMID: 24731696, PMCID: PMC4120525, PII: S0006-3223(14)00135-8, DOI: 10.1016/j.biopsych.2014.02.019, ISSN: 1873-2402.

Deutch AY. Parkinson's disease redefined. Lancet Neurol [print-electronic]. 2013 May; 12(5): 422-3. PMID: 23582176, PII: S1474-4422(13)70052-8, DOI: 10.1016/S1474-4422(13)70052-8, ISSN: 1474-4465.

Deutch, AY, Hedera P, Colbran RJ. REEPing the benefits of an animal model of hereditary spastic paraplegia. Journal of Clinical Investigation. 2013; 123(10): 4134-6.

Kusnoor SV, Bubser M, Deutch AY. The effects of nigrostriatal dopamine depletion on the thalamic parafascicular nucleus. Brain Res [print-electronic]. 2012 Mar 3/29/2012; 1446: 46-55. PMID: 22353754, PMCID: PMC3772731, PII: S0006-8993(12)00101-1, DOI: 10.1016/j.brainres.2012.01.040, ISSN: 1872-6240.

Rong Y, Wei P, Parris J, Guo H, Pattarini R, Correia K, Li L, Kusnoor SV, Deutch AY, Morgan JI. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. J. Neurochem. 2012 Feb; 120(4): 528-40. PMID: 22117778, PMCID: PMC3259274, DOI: 10.1111/j.1471-4159.2011.07604.x, ISSN: 1471-4159.

Klug JR, Mathur BN, Kash TL, Wang HD, Matthews RT, Robison AJ, Anderson ME, Deutch AY, Lovinger DM, Colbran RJ, Winder DG. Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability. PLoS ONE [print-electronic]. 2012; 7(9): e45323. PMID: 23028932, PMCID: PMC3448631, PII: PONE-D-12-17469, DOI: 10.1371/journal.pone.0045323, ISSN: 1932-6203.

Rong Y, Wei P, Parris J, Guo H, Pattarini R, Correia K, Li L, Kusnoor SV, Deutch AY, Morgan JI. Comparison of Cbln1 and Cbln2 functions using transgenic and knockout mice. J Neurochem. 2012; 120: 528-40.

Wei P, Pattarini R, Rong Y, Guo H, Bansal PK, Kusnoor SV, Deutch AY, Parris J, Morgan JI. The Cbln family of proteins interact with multiple signaling pathways. J Neurochem. 2012; 121: 717-29.

Ansah TA, Ferguson MC, Nayyar T, Deutch AY. Age- and duration-dependent effects of MPTP on cortical serotonin systems. Neurosci. Lett [print-electronic]. 2011 Oct 10/24/2011; 504(2): 160-4. PMID: 21964387, PMCID: PMC3210582, PII: S0304-3940(11)01301-2, DOI: 10.1016/j.neulet.2011.09.026, ISSN: 1872-7972.

Ansah TA, Ferguson MC, Nayyar T, Bubser M, Garcia BG, Deutch AY. Age- and duration-dependent effects of MPTP on cortical serotonin systems. Neurosci Lett. 2011; 504: 160-4.

Garcia BG, Neely MD, Deutch AY. Cortical regulation of striatal medium spiny neuron dendritic remodeling in parkinsonism: modulation of glutamate release reverses dopamine depletion-induced dendritic spine loss. Cereb. Cortex [print-electronic]. 2010 Oct; 20(10): 2423-32. PMID: 20118184, PMCID: PMC2936803, PII: bhp317, DOI: 10.1093/cercor/bhp317, ISSN: 1460-2199.

Gustin RM, Bichell TJ, Bubser M, Daily J, Filonova I, Mrelashvili D, Deutch AY, Colbran RJ, Weeber EJ, Haas KF. Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome. Neurobiol. Dis [print-electronic]. 2010 Sep; 39(3): 283-91. PMID: 20423730, PMCID: PMC2922926, PII: S0969-9961(10)00128-2, DOI: 10.1016/j.nbd.2010.04.012, ISSN: 1095-953X.

Kusnoor SV, Parris J, Muly EC, Morgan JI, Deutch AY. Extracerebellar role for Cerebellin1: modulation of dendritic spine density and synapses in striatal medium spiny neurons. J. Comp. Neurol. 2010 Jul 7/1/2010; 518(13): 2525-37. PMID: 20503425, PMCID: PMC2919330, DOI: 10.1002/cne.22350, ISSN: 1096-9861.

Ferguson MC, Nayyar T, Deutch AY, Ansah TA. 5-HT2A receptor antagonists improve motor impairments in the MPTP mouse model of Parkinson's disease. Neuropharmacology [print-electronic]. 2010 Jul; 59(1-2): 31-6. PMID: 20361986, PMCID: PMC2878885, PII: S0028-3908(10)00089-4, DOI: 10.1016/j.neuropharm.2010.03.013, ISSN: 1873-7064.

Wang HD, Stanwood GD, Grandy DK, Deutch AY. Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice. Brain Res [print-electronic]. 2009 Dec 12/1/2009; 1300: 58-64. PMID: 19747903, PMCID: PMC2783753, PII: S0006-8993(09)01882-4, DOI: 10.1016/j.brainres.2009.09.008, ISSN: 1872-6240.

Kusnoor SV, Muly EC, Morgan JI, Deutch AY. Is the loss of thalamostriatal neurons protective in parkinsonism?. Parkinsonism Relat. Disord. 2009 Dec; 15 Suppl 3: S162-6. PMID: 20082981, PMCID: PMC2900831, PII: S1353-8020(09)70806-5, DOI: 10.1016/S1353-8020(09)70806-5, ISSN: 1873-5126.

Neely MD, Stanwood GD, Deutch AY. Combination of diOlistic labeling with retrograde tract tracing and immunohistochemistry. J. Neurosci. Methods [print-electronic]. 2009 Nov 11/15/2009; 184(2): 332-6. PMID: 19712695, PMCID: PMC2796483, PII: S0165-0270(09)00449-X, DOI: 10.1016/j.jneumeth.2009.08.016, ISSN: 1872-678X.

Mathur BN, Caprioli RM, Deutch AY. Proteomic analysis illuminates a novel structural definition of the claustrum and insula. Cereb. Cortex [print-electronic]. 2009 Oct; 19(10): 2372-9. PMID: 19168664, PMCID: PMC2742595, PII: bhn253, DOI: 10.1093/cercor/bhn253, ISSN: 1460-2199.

Nayyar T, Bubser M, Ferguson MC, Neely MD, Shawn Goodwin J, Montine TJ, Deutch AY, Ansah TA. Cortical serotonin and norepinephrine denervation in parkinsonism: preferential loss of the beaded serotonin innervation. Eur. J. Neurosci. 2009 Jul; 30(2): 207-16. PMID: 19659923, PMCID: PMC2765981, PII: EJN6806, DOI: 10.1111/j.1460-9568.2009.06806.x, ISSN: 1460-9568.

Neely MD, Robert EM, Baucum AJ, Colbran RJ, Muly EC, Deutch AY. Localization of myocyte enhancer factor 2 in the rodent forebrain: regionally-specific cytoplasmic expression of MEF2A. Brain Res [print-electronic]. 2009 Jun 6/5/2009; 1274: 55-65. PMID: 19362076, PMCID: PMC2723059, PII: S0006-8993(09)00693-3, DOI: 10.1016/j.brainres.2009.03.067, ISSN: 1872-6240.

Kusnoor SV, Muly EC, Morgan JI, Deutch AY. Is the loss of thalamostriatal neurons protective in parkinsonism?. Parkinsonism and Related Disorders. 2009; 15 (S3): 162-6.

Jones CK, Brady AE, Davis AA, Xiang Z, Bubser M, Tantawy MN, Kane AS, Bridges TM, Kennedy JP, Bradley SR, Peterson TE, Ansari MS, Baldwin RM, Kessler RM, Deutch AY, Lah JJ, Levey AI, Lindsley CW, Conn PJ. Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J. Neurosci. 2008 Oct 10/8/2008; 28(41): 10422-33. PMID: 18842902, PMCID: PMC2577155, PII: 28/41/10422, DOI: 10.1523/JNEUROSCI.1850-08.2008, ISSN: 1529-2401.

Lieberman JA, Bymaster FP, Meltzer HY, Deutch AY, Duncan GE, Marx CE, Aprille JR, Dwyer DS, Li XM, Mahadik SP, Duman RS, Porter JH, Modica-Napolitano JS, Newton SS, Csernansky JG. Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection. Pharmacol. Rev. 2008 Sep; 60(3): 358-403. PMID: 18922967, PII: 60/3/358, DOI: 10.1124/pr.107.00107, ISSN: 1521-0081.

Wang HD, Deutch AY. Dopamine depletion of the prefrontal cortex induces dendritic spine loss: reversal by atypical antipsychotic drug treatment. Neuropsychopharmacology [print-electronic]. 2008 May; 33(6): 1276-86. PMID: 17687264, PII: 1301521, DOI: 10.1038/sj.npp.1301521, ISSN: 0893-133X.

Clark JA, Flick RB, Pai LY, Szalayova I, Key S, Conley RK, Deutch AY, Hutson PH, Mezey E. Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice. Mol. Psychiatry [print-electronic]. 2008 May; 13(5): 498-506. PMID: 17622221, PMCID: PMC3392182, PII: 4002041, DOI: 10.1038/, ISSN: 1476-5578.

Mathur BN, Deutch AY. Rat meningeal and brain microvasculature pericytes co-express the vesicular glutamate transporters 2 and 3. Neurosci. Lett [print-electronic]. 2008 Apr 4/18/2008; 435(2): 90-4. PMID: 18358609, PMCID: PMC3679921, PII: S0304-3940(08)00122-5, DOI: 10.1016/j.neulet.2008.01.082, ISSN: 0304-3940.

Andersson M, Groseclose MR, Deutch AY, Caprioli RM. Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction. Nat. Methods. 2008 Jan; 5(1): 101-8. PMID: 18165806, PII: nmeth1145, DOI: 10.1038/nmeth1145, ISSN: 1548-7105.

Deutch AY, Bubser M. The orexins/hypocretins and schizophrenia. Schizophr Bull [print-electronic]. 2007 Nov; 33(6): 1277-83. PMID: 17728265, PMCID: PMC2779882, PII: sbm096, DOI: 10.1093/schbul/sbm096, ISSN: 0586-7614.

Neely MD, Schmidt DE, Deutch AY. Cortical regulation of dopamine depletion-induced dendritic spine loss in striatal medium spiny neurons. Neuroscience [print-electronic]. 2007 Oct 10/26/2007; 149(2): 457-64. PMID: 17888581, PMCID: PMC2094700, PII: S0306-4522(07)00807-X, DOI: 10.1016/j.neuroscience.2007.06.044, ISSN: 0306-4522.

Mathur BN, Neely MD, Dyllick-Brenzinger M, Tandon A, Deutch AY. Systemic administration of a proteasome inhibitor does not cause nigrostriatal dopamine degeneration. Brain Res [print-electronic]. 2007 Sep 9/7/2007; 1168: 83-9. PMID: 17706185, PMCID: PMC2040265, PII: S0006-8993(07)01645-9, DOI: 10.1016/j.brainres.2007.06.076, ISSN: 0006-8993.

Hackler EA, Turner GH, Gresch PJ, Sengupta S, Deutch AY, Avison MJ, Gore JC, Sanders-Bush E. 5-Hydroxytryptamine2C receptor contribution to m-chlorophenylpiperazine and N-methyl-beta-carboline-3-carboxamide-induced anxiety-like behavior and limbic brain activation. J. Pharmacol. Exp. Ther [print-electronic]. 2007 Mar; 320(3): 1023-9. PMID: 17138863, PII: jpet.106.113357, DOI: 10.1124/jpet.106.113357, ISSN: 0022-3565.

Deutch AY, Colbran RJ, Winder DJ. Striatal plasticity and medium spiny neuron dendritic remodeling in parkinsonism. Parkinsonism Relat. Disord. 2007; 13 Suppl 3: S251-8. PMID: 18267246, PII: S1353-8020(08)70012-9, DOI: 10.1016/S1353-8020(08)70012-9, ISSN: 1353-8020.

Fadel J, Dobner PR, Deutch AY. Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice. Neurosci. Lett [print-electronic]. 2006 Jul 7/10/2006; 402(1-2): 97-101. PMID: 16632196, PII: S0304-3940(06)00316-8, DOI: 10.1016/j.neulet.2006.03.043, ISSN: 0304-3940.

Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL. P90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Mar 3/21/2006; 103(12): 4717-22. PMID: 16537434, PMCID: PMC1450237, PII: 0600585103, DOI: 10.1073/pnas.0600585103, ISSN: 0027-8424.

Day M, Wang Z, Ding J, An X, Ingham CA, Shering AF, Wokosin D, Ilijic E, Sun Z, Sampson AR, Mugnaini E, Deutch AY, Sesack SR, Arbuthnott GW, Surmeier DJ. Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models. Nat. Neurosci [print-electronic]. 2006 Feb; 9(2): 251-9. PMID: 16415865, PII: nn1632, DOI: 10.1038/nn1632, ISSN: 1097-6256.

Deutch AY, Winder DG. A channel to neurodegeneration. Nature medicine. 2006 Jan; 12(1) Sect. 17,8.

Deutch AY. Striatal plasticity in parkinsonism: dystrophic changes in medium spiny neurons and progression in Parkinson's disease. J. Neural Transm. Suppl. 2006; (70): 67-70. PMID: 17017511, ISSN: 0303-6995.

Brown AM, Deutch AY, Colbran RJ. Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism. Eur. J. Neurosci. 2005 Jul; 22(1): 247-56. PMID: 16029214, PII: EJN4190, DOI: 10.1111/j.1460-9568.2005.04190.x, ISSN: 0953-816X.

Bubser M, Fadel JR, Jackson LL, Meador-Woodruff JH, Jing D, Deutch AY. Dopaminergic regulation of orexin neurons. Eur. J. Neurosci. 2005 Jun; 21(11): 2993-3001. PMID: 15978010, PII: EJN4121, DOI: 10.1111/j.1460-9568.2005.04121.x, ISSN: 0953-816X.

Petrie KA, Schmidt D, Bubser M, Fadel J, Carraway RE, Deutch AY. Neurotensin activates GABAergic interneurons in the prefrontal cortex. J. Neurosci. 2005 Feb 2/16/2005; 25(7): 1629-36. PMID: 15716398, PII: 25/7/1629, DOI: 10.1523/JNEUROSCI.3579-04.2005, ISSN: 1529-2401.

Zaja-Milatovic S, Milatovic D, Schantz AM, Zhang J, Montine KS, Samii A, Deutch AY, Montine TJ. Dendritic degeneration in neostriatal medium spiny neurons in Parkinson disease. Neurology. 2005 Feb 2/8/2005; 64(3): 545-7. PMID: 15699393, PII: 64/3/545, DOI: 10.1212/01.WNL.0000150591.33787.A4, ISSN: 1526-632X.

Petrie KA, Bubser M, Casey CD, Davis MD, Roth BL, Deutch AY. The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat. Neuropsychopharmacology. 2004 Oct; 29(10): 1878-88. PMID: 15150532, PII: 1300494, DOI: 10.1038/sj.npp.1300494, ISSN: 0893-133X.

Wang HD, Dunnavant FD, Jarman T, Deutch AY. Effects of antipsychotic drugs on neurogenesis in the forebrain of the adult rat. Neuropsychopharmacology. 2004 Jul; 29(7): 1230-8. PMID: 15085089, PII: 1300449, DOI: 10.1038/sj.npp.1300449, ISSN: 0893-133X.

Rieck RW, Ansari MS, Whetsell WO, Deutch AY, Kessler RM. Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies. Neuropsychopharmacology. 2004 Feb; 29(2): 362-72. PMID: 14627996, PII: 1300336, DOI: 10.1038/sj.npp.1300336, ISSN: 0893-133X.

Gu G, Deutch AY, Franklin J, Levy S, Wallace DC, Zhang J. Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Biochem. Biophys. Res. Commun. 2003 Aug 8/15/2003; 308(1): 197-205. PMID: 12890501, PII: S0006291X03012336, ISSN: 0006-291X.

Scruggs JL, Schmidt D, Deutch AY. The hallucinogen 1-[2,5-dimethoxy-4-iodophenyl]-2-aminopropane (DOI) increases cortical extracellular glutamate levels in rats. Neurosci. Lett. 2003 Aug 8/7/2003; 346(3): 137-40. PMID: 12853103, PII: S0304394003005470, ISSN: 0304-3940.

Dobner PR, Deutch AY, Fadel J. Neurotensin: dual roles in psychostimulant and antipsychotic drug responses. Life Sci. 2003 Jun 6/27/2003; 73(6): 801-11. PMID: 12801600, PII: S0024320503004119, ISSN: 0024-3205.

Deutch AY, Roth RH. Neurotransmitters. Fundamental Neuroscience (Squire LR, Bloom FE, McConnell SK, Roberts JL, Spitzer NC, Zigmond MJ Eds), Academic Press, New York, pp 163-196 (Second edition). 2003; (()).

Fadel J, Bubser M, Deutch AY. Differential activation of orexin neurons by antipsychotic drugs associated with weight gain. J. Neurosci. 2002 Aug 8/1/2002; 22(15): 6742-6. PMID: 12151553, PII: 22/15/6742, DOI: 20026632, ISSN: 1529-2401.

Bubser M, Deutch AY. Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum. Eur. J. Neurosci. 2002 Feb; 15(4): 713-20. PMID: 11886451, ISSN: 0953-816X.

Woo NS, Lu J, England R, McClellan R, Dufour S, Mount DB, Deutch AY, Lovinger DM, Delpire E. Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. Hippocampus. 2002; 12(2): 258-68. PMID: 12000122, DOI: 10.1002/hipo.10014, ISSN: 1050-9631.

Fadel J, Deutch AY. Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area. Neuroscience. 2002; 111(2): 379-87. PMID: 11983323, PII: S0306452202000179, ISSN: 0306-4522.

Dobner PR, Fadel J, Deitemeyer N, Carraway RE, Deutch AY. Neurotensin-deficient mice show altered responses to antipsychotic drugs. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Jul 7/3/2001; 98(14): 8048-53. PMID: 11427716, PMCID: PMC35465, PII: 141042198, DOI: 10.1073/pnas.141042198, ISSN: 0027-8424.

Deutch AY. Introduction. Parkinsonism Relat. Disord. 2001 Jul; 7(3): 163. PMID: 11331181, PII: S1353-8020(00)00052-3, ISSN: 1873-5126.

Fadel J, Dobner PR, Deutch AY. The neurotensin antagonist SR 48692 attenuates haloperidol-induced striatal Fos expression in the rat. Neurosci. Lett. 2001 Apr 4/27/2001; 303(1): 17-20. PMID: 11297813, PII: S0304394001017086, ISSN: 0304-3940.

Bubser M, Backstrom JR, Sanders-Bush E, Roth BL, Deutch AY. Distribution of serotonin 5-HT(2A) receptors in afferents of the rat striatum. Synapse. 2001 Mar 3/15/2001; 39(4): 297-304. PMID: 11169779, PII: 10.1002/1098-2396(20010315)39:4<297::AID-SYN1012>3.0.CO;2-Q, DOI: 10.1002/1098-2396(20010315)39:4<297::AID-SYN1012>3.0.CO;2-Q, ISSN: 0887-4476.

Scruggs JL, Patel S, Bubser M, Deutch AY. DOI-Induced activation of the cortex: dependence on 5-HT2A heteroceptors on thalamocortical glutamatergic neurons. J. Neurosci. 2000 Dec 12/1/2000; 20(23): 8846-52. PMID: 11102493, PII: 20/23/8846, ISSN: 1529-2401.

Salvatore MF, Garcia-Espana A, Goldstein M, Deutch AY, Haycock JW. Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. J. Neurochem. 2000 Jul; 75(1): 225-32. PMID: 10854265, ISSN: 0022-3042.

Bubser M, Scruggs JL, Young CD, Deutch AY. The distribution and origin of the calretinin-containing innervation of the nucleus accumbens of the rat. Eur. J. Neurosci. 2000 May; 12(5): 1591-8. PMID: 10792437, PII: ejn052, ISSN: 0953-816X.

Young CD, Bubser M, Meltzer HY, Deutch AY. Clozapine pretreatment modifies haloperidol-elicited forebrain Fos induction: a regionally-specific double dissociation. Psychopharmacology (Berl.). 1999 Jun; 144(3): 255-63. PMID: 10435392, ISSN: 0033-3158.

Bubser M, Deutch AY. Stress induces Fos expression in neurons of the thalamic paraventricular nucleus that innervate limbic forebrain sites. Synapse. 1999 Apr; 32(1): 13-22. PMID: 10188633, PII: 10.1002/(SICI)1098-2396(199904)32:1<13::AID-SYN2>3.0.CO;2-R, DOI: 10.1002/(SICI)1098-2396(199904)32:1<13::AID-SYN2>3.0.CO;2-R, ISSN: 0887-4476.

Abi-Saab WM, Bubser M, Roth RH, Deutch AY. 5-HT2 receptor regulation of extracellular GABA levels in the prefrontal cortex. Neuropsychopharmacology. 1999 Jan; 20(1): 92-6. PMID: 9885788, PII: S0893-133X(98)00046-3, DOI: 10.1016/S0893-133X(98)00046-3, ISSN: 0893-133X.

Deutch AY, Bubser M, Young CD. Psychostimulant-induced Fos protein expression in the thalamic paraventricular nucleus. J. Neurosci. 1998 Dec 12/15/1998; 18(24): 10680-7. PMID: 9852603, ISSN: 0270-6474.

Young CD, Deutch AY. The effects of thalamic paraventricular nucleus lesions on cocaine-induced locomotor activity and sensitization. Pharmacol. Biochem. Behav. 1998 Jul; 60(3): 753-8. PMID: 9678661, PII: S0091-3057(98)00051-3, ISSN: 0091-3057.

Young CD, Meltzer HY, Deutch AY. Effects of desmethylclozapine on Fos protein expression in the forebrain: in vivo biological activity of the clozapine metabolite. Neuropsychopharmacology. 1998 Jul; 19(1): 99-103. PMID: 9608582, PII: S0893133X97002030, DOI: 10.1016/S0893-133X(97)00203-0, ISSN: 0893-133X.

Grobin AC, Deutch AY. Dopaminergic regulation of extracellular gamma-aminobutyric acid levels in the prefrontal cortex of the rat. J. Pharmacol. Exp. Ther. 1998 Apr; 285(1): 350-7. PMID: 9536031, ISSN: 0022-3565.

Bubser M, Deutch AY. Thalamic paraventricular nucleus neurons collateralize to innervate the prefrontal cortex and nucleus accumbens. Brain Res. 1998 Mar 3/23/1998; 787(2): 304-10. PMID: 9518661, PII: S0006-8993(97)01373-5, ISSN: 0006-8993.

Willins DL, Deutch AY, Roth BL. Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex. Synapse. 1997 Sep; 27(1): 79-82. PMID: 9268067, PII: 10.1002/(SICI)1098-2396(199709)27:1<79::AID-SYN8>3.0.CO;2-A, DOI: 10.1002/(SICI)1098-2396(199709)27:1<79::AID-SYN8>3.0.CO;2-A, ISSN: 0887-4476.

Deutch AY, Lewis DA, Whitehead RE, Elsworth JD, Iadarola MJ, Redmond DE, Roth RH. Effects of D2 dopamine receptor antagonists on Fos protein expression in the striatal complex and entorhinal cortex of the nonhuman primate. Synapse. 1996 Jul; 23(3): 182-91. PMID: 8807746, PII: 10.1002/(SICI)1098-2396(199607)23:3<182::AID-SYN7>3.0.CO;2-4, DOI: 10.1002/(SICI)1098-2396(199607)23:3<182::AID-SYN7>3.0.CO;2-4, ISSN: 0887-4476.

Deutch AY, Duman RS. The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization. Neuroscience. 1996 Jan; 70(2): 377-89. PMID: 8848147, PII: 0306-4522(95)00357-6, ISSN: 0306-4522.

Goldstein M, Lee KY, Lew JY, Harada K, Wu J, Haycock JW, Hokfelt T, Deutch AY. Antibodies to a segment of tyrosine hydroxylase phosphorylated at serine 40. J. Neurochem. 1995 May; 64(5): 2281-7. PMID: 7722513, ISSN: 0022-3042.

Deutch AY, Ongür D, Duman RS. Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action. Neuroscience. 1995 May; 66(2): 337-46. PMID: 7477876, PII: 0306-4522(94)00571-L, ISSN: 0306-4522.

Fitzgerald LW, Deutch AY, Gasic G, Heinemann SF, Nestler EJ. Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs. J. Neurosci. 1995 Mar; 15(3 Pt 2): 2453-61. PMID: 7891180, ISSN: 0270-6474.

Rasmusson AM, Goldstein LE, Deutch AY, Bunney BS, Roth RH. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse. 1994 Nov; 18(3): 218-24. PMID: 7855734, DOI: 10.1002/syn.890180307, ISSN: 0887-4476.

Deutch AY. Identification of the neural systems subserving the actions of clozapine: clues from immediate-early gene expression. J Clin Psychiatry. 1994 Sep; 55 Suppl B: 37-42. PMID: 7961570, ISSN: 0160-6689.

Bourdelais AJ, Deutch AY. The effects of haloperidol and clozapine on extracellular GABA levels in the prefrontal cortex of the rat: an in vivo microdialysis study. Cereb. Cortex. 1994 Jan; 4(1): 69-77. PMID: 8180492, ISSN: 1047-3211.

Brog JS, Salyapongse A, Deutch AY, Zahm DS. The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: immunohistochemical detection of retrogradely transported fluoro-gold. J. Comp. Neurol. 1993 Dec 12/8/1993; 338(2): 255-78. PMID: 8308171, DOI: 10.1002/cne.903380209, ISSN: 0021-9967.

Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. Psychobiologic mechanisms of posttraumatic stress disorder. Arch. Gen. Psychiatry. 1993 Apr; 50(4): 295-305. PMID: 8466391, ISSN: 0003-990X.

Deutch AY. Prefrontal cortical dopamine systems and the elaboration of functional corticostriatal circuits: implications for schizophrenia and Parkinson's disease. J. Neural Transm. Gen. Sect. 1993; 91(2-3): 197-221. PMID: 8099797.

Duman RS, Craig JS, Winston SM, Deutch AY, Hernandez TD. Amygdala kindling potentiates seizure-stimulated immediate-early gene expression in rat cerebral cortex. J. Neurochem. 1992 Nov; 59(5): 1753-60. PMID: 1402920, ISSN: 0022-3042.

Klitenick MA, Deutch AY, Churchill L, Kalivas PW. Topography and functional role of dopaminergic projections from the ventral mesencephalic tegmentum to the ventral pallidum. Neuroscience. 1992 Sep; 50(2): 371-86. PMID: 1279461, PII: 0306-4522(92)90430-A, ISSN: 0306-4522.

Clark JA, Deutch AY, Gallipoli PZ, Amara SG. Functional expression and CNS distribution of a beta-alanine-sensitive neuronal GABA transporter. Neuron. 1992 Aug; 9(2): 337-48. PMID: 1497897, PII: 0896-6273(92)90172-A, ISSN: 0896-6273.

Deutch AY, Lee MC, Iadarola MJ. Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: The nucleus accumbens shell as a locus of antipsychotic action. Mol. Cell. Neurosci. 1992 Aug; 3(4): 332-41. PMID: 19912876, PII: 1044-7431(92)90030-6, ISSN: 1044-7431.

Rosin DL, Clark WA, Goldstein M, Roth RH, Deutch AY. Effects of 6-hydroxydopamine lesions of the prefrontal cortex on tyrosine hydroxylase activity in mesolimbic and nigrostriatal dopamine systems. Neuroscience. 1992 Jun; 48(4): 831-9. PMID: 1352864, PII: 0306-4522(92)90271-3, ISSN: 0306-4522.

Grobin AC, Roth RH, Deutch AY. Regulation of the prefrontal cortical dopamine system by the neuroactive steroid 3a,21-dihydroxy-5a-pregnane-20-one. Brain Res. 1992 Apr 4/24/1992; 578(1-2): 351-6. PMID: 1511287, PII: 0006-8993(92)90270-J, ISSN: 0006-8993.

Goldstein M, Deutch AY. Dopaminergic mechanisms in the pathogenesis of schizophrenia. FASEB J. 1992 Apr; 6(7): 2413-21. PMID: 1348713, ISSN: 0892-6638.

During MJ, Freese A, Deutch AY, Kibat PG, Sabel BA, Langer R, Roth RH. Biochemical and behavioral recovery in a rodent model of Parkinson's disease following stereotactic implantation of dopamine-containing liposomes. Exp. Neurol. 1992 Feb; 115(2): 193-9. PMID: 1735466, PII: 0014-4886(92)90053-S, ISSN: 0014-4886.

Deutch AY. The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia. J. Neural Transm. Suppl. 1992; 36: 61-89. PMID: 1527521, ISSN: 0303-6995.

Deutch AY, Zahm DS. The current status of neurotensin-dopamine interactions. Issues and speculations. Ann. N. Y. Acad. Sci. 1992; 668: 232-52. PMID: 1361115, ISSN: 0077-8923.

Deutch AY, Cameron DS. Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell. Neuroscience. 1992; 46(1): 49-56. PMID: 1350665, ISSN: 0306-4522.

Deutch AY, Lee MC, Gillham MH, Cameron DA, Goldstein M, Iadarola MJ. Stress selectively increases fos protein in dopamine neurons innervating the prefrontal cortex. Cereb. Cortex. 1991 Jul; 1(4): 273-92. PMID: 1668366, ISSN: 1047-3211.

Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophr. Res. 1991 Mar; 4(2): 121-56. PMID: 1674882, PII: 0920-9964(91)90030-U, ISSN: 0920-9964.

Janson AM, Fuxe K, Goldstein M, Deutch AY. Hypertrophy of dopamine neurons in the primate following ventromedial mesencephalic tegmentum lesion. Exp Brain Res. 1991; 87(1): 232-8. PMID: 1756831, ISSN: 0014-4819.

Deutch AY, Elsworth JD, Roth RH, Goldstein M. 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation. Brain Res. 1990 Sep 9/10/1990; 527(1): 96-102. PMID: 2126479, ISSN: 0006-8993.

Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH. MPTP reduces dopamine and norepinephrine concentrations in the supplementary motor area and cingulate cortex of the primate. Neurosci. Lett. 1990 Jul 7/13/1990; 114(3): 316-22. PMID: 2402341, ISSN: 0304-3940.

Deutch AY, During MJ. A cautionary note on the potential benefits of striatal dopamine implants [letter]. Ann. Neurol. 1990 Jul; 28(1): 111. PMID: 2375628, DOI: 10.1002/ana.410280127, ISSN: 0364-5134.

Deutch AY, Clark WA, Roth RH. Prefrontal cortical dopamine depletion enhances the responsiveness of mesolimbic dopamine neurons to stress. Brain Res. 1990 Jun 6/25/1990; 521(1-2): 311-5. PMID: 2119850, PII: 0006-8993(90)91557-W, ISSN: 0006-8993.

Gruen RJ, Deutch AY, Roth RH. Perinatal diazepam exposure: alterations in exploratory behavior and mesolimbic dopamine turnover. Pharmacol. Biochem. Behav. 1990 May; 36(1): 169-75. PMID: 2349259, PII: 0091-3057(90)90144-7, ISSN: 0091-3057.

Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH. MPTP-induced parkinsonism: relative changes in dopamine concentration in subregions of substantia nigra, ventral tegmental area and retrorubral field of symptomatic and asymptomatic vervet monkeys. Brain Res. 1990 Apr 4/16/1990; 513(2): 320-4. PMID: 2350702, PII: 0006-8993(90)90474-P, ISSN: 0006-8993.

Robbins RJ, Torres-Aleman I, Lebranth C, Bradberry CW, Deutch AY, Welsh S, Roth RH, Spencer D, Redmond DE, Naftolin F. Cryopreservation of human brain tissue. Exp. Neurol. 1990 Mar; 107(3): 208-13. PMID: 1968397, ISSN: 0014-4886.

Deutch AY, Roth RH. The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog. Brain Res. 1990; 85: 367-402; discussion 402. PMID: 2094906, ISSN: 0079-6123.

Sesack SR, Deutch AY, Roth RH, Bunney BS. Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J. Comp. Neurol. 1989 Dec 12/8/1989; 290(2): 213-42. PMID: 2592611, DOI: 10.1002/cne.902900205, ISSN: 0021-9967.

Bean AJ, During MJ, Deutch AY, Roth RH. Effects of dopamine depletion on striatal neurotensin: biochemical and immunohistochemical studies. J. Neurosci. 1989 Dec; 9(12): 4430-8. PMID: 2593006, ISSN: 0270-6474.

Lee KY, Lew JY, Tang D, Schlesinger DH, Deutch AY, Goldstein M. Antibodies to a synthetic peptide corresponding to a Ser-40-containing segment of tyrosine hydroxylase: activation and immunohistochemical localization of tyrosine hydroxylase. J. Neurochem. 1989 Oct; 53(4): 1238-44. PMID: 2570128, ISSN: 0022-3042.

Yurek DM, Deutch AY, Roth RH, Sladek JR. Morphological, neurochemical, and behavioral characterizations associated with the combined treatment of diethyldithiocarbamate and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Brain Res. 1989 Sep 9/18/1989; 497(2): 250-9. PMID: 2573405, PII: 0006-8993(89)90270-9, ISSN: 0006-8993.

Knorr AM, Deutch AY, Roth RH. The anxiogenic beta-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 1989 Aug 8/28/1989; 495(2): 355-61. PMID: 2765936, PII: 0006-8993(89)90228-X, ISSN: 0006-8993.

Deutch AY, Rosin DL, Goldstein M, Roth RH. 3-Acetylpyridine-induced degeneration of the nigrostriatal dopamine system: an animal model of olivopontocerebellar atrophy-associated parkinsonism. Exp. Neurol. 1989 Jul; 105(1): 1-9. PMID: 2568269, ISSN: 0014-4886.

Deutch AY, Gruen RJ, Roth RH. The effects of perinatal diazepam exposure on stress-induced activation of the mesotelencephalic dopamine system. Neuropsychopharmacology. 1989 Jun; 2(2): 105-14. PMID: 2742725, PII: 0893-133X(89)90013-4, ISSN: 0893-133X.

Elsworth JD, Deutch AY, Redmond DE, Taylor JR, Sladek JR, Roth RH. Symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates: biochemical changes in striatal regions. Neuroscience. 1989; 33(2): 323-31. PMID: 2622529, ISSN: 0306-4522.

Bradberry CW, Karasic DH, Deutch AY, Roth RH. Regionally-specific alterations in mesotelencephalic dopamine synthesis in diabetic rats: association with precursor tyrosine. J. Neural Transm. Gen. Sect. 1989; 78(3): 221-9. PMID: 2529883.

Goldstein M, Lieberman AN, Helmer E, Koslow M, Ransohoff J, Elsworth JD, Roth RH, Deutch AY. Biochemical analysis of caudate nucleus biopsy samples from parkinsonian patients. Ann. Neurol. 1988 Nov; 24(5): 685-8. PMID: 2904793, DOI: 10.1002/ana.410240517, ISSN: 0364-5134.

Deutch AY, Bean AJ, Roth RH. Regulation of A8 dopamine neurons by somatostatin. Eur. J. Pharmacol. 1988 Mar 3/1/1988; 147(2): 317-20. PMID: 2896598, ISSN: 0014-2999.

Roth RH, Tam SY, Ida Y, Yang JX, Deutch AY. Stress and the mesocorticolimbic dopamine systems. Ann. N. Y. Acad. Sci. 1988; 537: 138-47. PMID: 3059920, ISSN: 0077-8923.

Deutch AY, Goldstein M, Baldino F, Roth RH. Telencephalic projections of the A8 dopamine cell group. Ann. N. Y. Acad. Sci. 1988; 537: 27-50. PMID: 2462395, ISSN: 0077-8923.

Deutch AY, Holliday J, Roth RH, Chun LL, Hawrot E. Immunohistochemical localization of a neuronal nicotinic acetylcholine receptor in mammalian brain. Proc. Natl. Acad. Sci. U.S.A. 1987 Dec; 84(23): 8697-701. PMID: 3317419, PMCID: PMC299613, ISSN: 0027-8424.

Deutch AY, Bean AJ, Bissette G, Nemeroff CB, Robbins RJ, Roth RH. Stress-induced alterations in neurotensin, somatostatin and corticotropin-releasing factor in mesotelencephalic dopamine system regions. Brain Res. 1987 Aug 8/11/1987; 417(2): 350-4. PMID: 2888514, PII: 0006-8993(87)90462-8, ISSN: 0006-8993.

Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF. Brain Res. 1987 Jul 7/14/1987; 415(2): 293-9. PMID: 3496938, PII: 0006-8993(87)90211-3, ISSN: 0006-8993.

Deutch AY, Tam SY, Freeman AS, Bowers MB, Roth RH. Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. Eur. J. Pharmacol. 1987 Feb 2/24/1987; 134(3): 257-64. PMID: 3569414, ISSN: 0014-2999.

Deutch AY, Roth RH. Calcitonin gene-related peptide in the ventral tegmental area: selective modulation of prefrontal cortical dopamine metabolism. Neurosci. Lett. 1987 Feb 2/24/1987; 74(2): 169-74. PMID: 3554009, ISSN: 0304-3940.

Elsworth JD, Deutch AY, Redmond DE, Sladek JR, Roth RH. Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. Life Sci. 1987 Jan 1/12/1987; 40(2): 193-202. PMID: 3491946, ISSN: 0024-3205.

Sladek JR, Redmond DE, Collier TJ, Haber SN, Elsworth JD, Deutch AY, Roth RH. Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Prog. Brain Res. 1987; 71: 309-23. PMID: 3495818, ISSN: 0079-6123.

Sladek JR, Collier TJ, Haber SN, Deutch AY, Elsworth JD, Roth RH, Redmond DE. Reversal of parkinsonism by fetal nerve cell transplants in primate brain. Ann. N. Y. Acad. Sci. 1987; 495: 641-57. PMID: 2886092, ISSN: 0077-8923.

Deutch AY, Goldstein M, Roth RH. The ascending projections of the dopaminergic neurons of the substantia nigra, zona reticulata: a combined retrograde tracer-immunohistochemical study. Neurosci. Lett. 1986 Nov 11/21/1986; 71(3): 257-63. PMID: 2879262, ISSN: 0304-3940.

Redmond DE, Sladek JR, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S. Transplants of primate neurons [letter]. Lancet. 1986 Nov 11/1/1986; 2(8514): 1046. PMID: 2877218, PII: S0140-6736(86)92664-4, ISSN: 0140-6736.

Bannon MJ, Deutch AY, Tam SY, Zamir N, Eskay RL, Lee JM, Maggio JE, Roth RH. Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin. Brain Res. 1986 Sep 9/3/1986; 381(2): 393-6. PMID: 2428438, PII: 0006-8993(86)90097-1, ISSN: 0006-8993.

Deutch AY, Elsworth JD, Goldstein M, Fuxe K, Redmond DE, Sladek JR, Roth RH. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurosci. Lett. 1986 Jul 7/11/1986; 68(1): 51-6. PMID: 3487756, ISSN: 0304-3940.

Redmond DE, Sladek JR, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S. Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Lancet. 1986 May 5/17/1986; 1(8490): 1125-7. PMID: 2871381, PII: S0140-6736(86)91839-8, ISSN: 0140-6736.

Deutch AY, Goldstein M, Roth RH. Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area. Brain Res. 1986 Jan 1/22/1986; 363(2): 307-14. PMID: 3942901, PII: 0006-8993(86)91016-4, ISSN: 0006-8993.

Kalivas PW, Deutch AY, Maggio JE, Mantyh PW, Roth RH. Substance K and substance P in the ventral tegmental area. Neurosci. Lett. 1985 Jun 6/24/1985; 57(3): 241-6. PMID: 2412193, ISSN: 0304-3940.

Deutch AY, Tam SY, Roth RH. Footshock and conditioned stress increase 3,4-dihydroxyphenylacetic acid (DOPAC) in the ventral tegmental area but not substantia nigra. Brain Res. 1985 Apr 4/29/1985; 333(1): 143-6. PMID: 3995282, PII: 0006-8993(85)90134-9, ISSN: 0006-8993.

Deutch AY, Maggio JE, Bannon MJ, Kalivas PW, Tam SY, Goldstein M, Roth RH. Substance K and substance P differentially modulate mesolimbic and mesocortical systems. Peptides. 1985; 6 Suppl 2: 113-22. PMID: 2417207, ISSN: 0196-9781.

Deutch AY, Clark LS, Peacock LJ. Kainic acid stimulation of the lateral septum elicits tachycardia. Brain Res. Bull. 1984 Mar; 12(3): 209-14. PMID: 6144375, ISSN: 0361-9230.

Deutch AY, Martin RJ. Mesencephalic dopamine modulation of pituitary and central beta-endorphin: relation to food intake regulation. Life Sci. 1983 Jul 7/18/1983; 33(3): 281-7. PMID: 6865661, ISSN: 0024-3205.