Faculty Appointments
Professor of Ophthalmology and Visual Sciences
Professor of Cell and Developmental BiologyProfessor of Medical Education & Administration (VUMC)Professor of Molecular Physiology and Biophysics
Education
Ph.D., Molecular Biophysics, Florida State University, Tallahassee, FloridaM.S., Marine Biology, University of West Florida, Pensacola, FloridaB.A., Biology, University of the South, Sewanee, Tennessee
Office Address
1161 21st Avenue S
Medical Center North B3307A
Nashville, TN 37232
Medical Center North B3307A
Nashville, TN 37232
Research Description
Penn's long-standing interest is in the molecular basis of retinal vascular disease. The over-reaching goal of his research is to characterize the processes involved in retinal vascular inflammation and angiogenesis, and to begin to develop preventive strategies based on understanding gained from in vitro and in vivo studies. The Penn lab has the capability to isolate and culture a variety of primary cells from retinal tissue of several species, including retinal vascular endothelial cells, choroidal endothelial cells, retinal Müller glia, retinal pericytes and retinal pigment epithelial cells – all of which are involved in vascular diseases of the retina. In addition, the lab uses a battery of in vivo models of vascular diseases of the eye including rodent models of retinopathy of prematurity, neovascular age-related degeneration and diabetic retinopathy. Using these in vitro and in vivo tools, Penn's research program focuses on pro-inflammatory and pro-angiogenic molecular signaling in the retina with an emphasis on drug target identification, and development of novel targeted therapies and mechanisms of drug delivery to the eye.
Penn has been continuously funded by the National Eye Institute of NIH for 30 years. He is currently the President of the International Society for Eye Research.
Penn has been continuously funded by the National Eye Institute of NIH for 30 years. He is currently the President of the International Society for Eye Research.
Research Keywords
Drug development, vascular biology, imaging, molecular pathology, retinopathy, inflammatory cytokines, molecular biology, cell biology
Clinical Research Keywords
Ocular angiogenesis, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration
Publications
Padovani-Claudio DA, Ramos CJ, Capozzi ME, Penn JS. Elucidating glial responses to products of diabetes-associated systemic dyshomeostasis. Prog Retin Eye Res [print-electronic]. 2023 May; 94: 101151. PMID: 37028118, PII: S1350-9462(22)00111-2, DOI: 10.1016/j.preteyeres.2022.101151, ISSN: 1873-1635.
Giblin MJ, Ontko CD, Penn JS. Effect of cytokine-induced alterations in extracellular matrix composition on diabetic retinopathy-relevant endothelial cell behaviors. Sci Rep. 2022 Jul 7/28/2022; 12(1): 12955. PMID: 35902594, PMCID: PMC9334268, PII: 10.1038/s41598-022-12683-7, DOI: 10.1038/s41598-022-12683-7, ISSN: 2045-2322.
Paguaga ME, Penn JS, Uddin MI. A novel optical imaging probe for targeted visualization of NLRP3 inflammasomes in a mouse model of age-related macular degeneration. Front Med (Lausanne). 2022; 9: 1047791. PMID: 36703888, PMCID: PMC9871584, DOI: 10.3389/fmed.2022.1047791, ISSN: 2296-858X.
Giblin MJ, Smith TE, Winkler G, Pendergrass HA, Kim MJ, Capozzi ME, Yang R, McCollum GW, Penn JS. Nuclear factor of activated T-cells (NFAT) regulation of IL-1ß-induced retinal vascular inflammation. Biochim Biophys Acta Mol Basis Dis [print-electronic]. 2021 Dec 12/1/2021; 1867(12): 166238. PMID: 34343639, PMCID: PMC8565496, PII: S0925-4439(21)00171-X, DOI: 10.1016/j.bbadis.2021.166238, ISSN: 1879-260X.
Ontko CD, Capozzi ME, Kim MJ, McCollum GW, Penn JS. Cytochrome P450-epoxygenated fatty acids inhibit Müller glial inflammation. Sci Rep. 2021 May 5/6/2021; 11(1): 9677. PMID: 33958662, PMCID: PMC8102485, PII: 10.1038/s41598-021-89000-1, DOI: 10.1038/s41598-021-89000-1, ISSN: 2045-2322.
Uddin MI, Kilburn TC, Jamal SZ, Duvall CL, Penn JS. A novel method for visualizing and tracking endogenous mRNA in a specific cell population in pathological neovascularization. Sci Rep. 2021 Jan 1/28/2021; 11(1): 2565. PMID: 33510218, PMCID: PMC7844016, PII: 10.1038/s41598-021-81367-5, DOI: 10.1038/s41598-021-81367-5, ISSN: 2045-2322.
Uddin MI, Kilburn TC, Duvall CL, Penn JS. Visualizing HIF-1a mRNA in a Subpopulation of Bone Marrow-Derived Cells to Predict Retinal Neovascularization. ACS Chem Biol [print-electronic]. 2020 Nov 11/20/2020; 15(11): 3004-12. PMID: 33080135, PMCID: PMC8121337, DOI: 10.1021/acschembio.0c00662, ISSN: 1554-8937.
Capozzi ME, Savage SR, McCollum GW, Hammer SS, Ramos CJ, Yang R, Bretz CA, Penn JS. The peroxisome proliferator-activated receptor-ß/d antagonist GSK0660 mitigates retinal cell inflammation and leukostasis. Exp Eye Res [print-electronic]. 2020 Jan; 190: 107885. PMID: 31758977, PMCID: PMC7426872, PII: S0014-4835(19)30521-4, DOI: 10.1016/j.exer.2019.107885, ISSN: 1096-0007.
Cao J, Yang R, Smith TE, Evans S, McCollum GW, Pomerantz SC, Petley T, Harris IR, Penn JS. Human Umbilical Tissue-Derived Cells Secrete Soluble VEGFR1 and Inhibit Choroidal Neovascularization. Mol Ther Methods Clin Dev. 2019 Sep 9/13/2019; 14: 37-46. PMID: 31276010, PMCID: PMC6586593, PII: S2329-0501(19)30051-8, DOI: 10.1016/j.omtm.2019.05.007, ISSN: 2329-0501.
Gordon AY, Lapierre-Landry M, Skala MC, Penn JS. Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents. Transl Vis Sci Technol. 2019 May; 8(3): 18. PMID: 31131155, PMCID: PMC6519216, PII: TVST-18-1100, DOI: 10.1167/tvst.8.3.18, ISSN: 2164-2591.
Uddin MI, Kilburn TC, Yang R, McCollum GW, Wright DW, Penn JS. Targeted Imaging of VCAM-1 mRNA in a Mouse Model of Laser-Induced Choroidal Neovascularization Using Antisense Hairpin-DNA-Functionalized Gold-Nanoparticles. Mol Pharm [print-electronic]. 2018 Dec 12/3/2018; 15(12): 5514-20. PMID: 30350640, PMCID: PMC7135968, DOI: 10.1021/acs.molpharmaceut.8b00661, ISSN: 1543-8392.
Capozzi ME, Giblin MJ, Penn JS. Palmitic Acid Induces Müller Cell Inflammation that is Potentiated by Co-treatment with Glucose. Sci Rep. 2018 Apr 4/3/2018; 8(1): 5459. PMID: 29626212, PMCID: PMC5889388, PII: 10.1038/s41598-018-23601-1, DOI: 10.1038/s41598-018-23601-1, ISSN: 2045-2322.
Uddin MI, Jayagopal A, Wong A, McCollum GW, Wright DW, Penn JS. Real-time imaging of VCAM-1 mRNA in TNF-a activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles. Nanomedicine [print-electronic]. 2018 Jan; 14(1): 63-71. PMID: 28890107, PMCID: PMC5742066, PII: S1549-9634(17)30165-X, DOI: 10.1016/j.nano.2017.08.018, ISSN: 1549-9642.
Lapierre-Landry M, Gordon AY, Penn JS, Skala MC. In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye. Sci Rep. 2017 Aug 8/23/2017; 7(1): 9228. PMID: 28835698, PMCID: PMC5569082, PII: 10.1038/s41598-017-10050-5, DOI: 10.1038/s41598-017-10050-5, ISSN: 2045-2322.
Uddin MI, Jayagopal A, McCollum GW, Yang R, Penn JS. In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO). Invest Ophthalmol Vis Sci. 2017 Jul 7/1/2017; 58(9): 3818-24. PMID: 28750413, PMCID: PMC5531786, PII: 2646756, DOI: 10.1167/iovs.16-21187, ISSN: 1552-5783.
Uddin MI, Evans SM, Craft JR, Capozzi ME, McCollum GW, Yang R, Marnett LJ, Uddin MJ, Jayagopal A, Penn JS. In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Sci Rep. 2016 Aug 8/5/2016; 6: 31011. PMID: 27491345, PMCID: PMC4974503, PII: srep31011, DOI: 10.1038/srep31011, ISSN: 2045-2322.
Suarez S, McCollum GW, Jayagopal A, Penn JS. High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1. J. Biol. Chem [print-electronic]. 2015 Nov 11/20/2015; 290(47): 28311-20. PMID: 26438826, PMCID: PMC4653686, PII: M115.682385, DOI: 10.1074/jbc.M115.682385, ISSN: 1083-351X.
Savage SR, McCollum GW, Yang R, Penn JS. RNA-seq identifies a role for the PPARß/d inverse agonist GSK0660 in the regulation of TNFa-induced cytokine signaling in retinal endothelial cells. Mol. Vis. 2015; 21: 568-76. PMID: 26015769, PMCID: PMC4443583, ISSN: 1090-0535.
Savage SR, Bretz CA, Penn JS. RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFa. PLoS ONE. 2015; 10(1): e0116941. PMID: 25617622, PMCID: PMC4305319, PII: PONE-D-14-43273, DOI: 10.1371/journal.pone.0116941, ISSN: 1932-6203.
Bretz CA, Savage SR, Capozzi ME, Suarez S, Penn JS. NFAT isoforms play distinct roles in TNFa-induced retinal leukostasis. Sci Rep. 2015; 5: 14963. PMID: 26527057, PMCID: PMC4630625, PII: srep14963, DOI: 10.1038/srep14963, ISSN: 2045-2322.
Suarez S, McCollum GW, Bretz CA, Yang R, Capozzi ME, Penn JS. Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-ß/d. Invest. Ophthalmol. Vis. Sci. 2014 Dec; 55(12): 8232-40. PMID: 25406289, PMCID: PMC4271638, PII: iovs.14-14217, DOI: 10.1167/iovs.14-14217, ISSN: 1552-5783.
Barnett JM, Suarez S, McCollum GW, Penn JS. Endoglin promotes angiogenesis in cell- and animal-based models of retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 2014 Oct; 55(10): 6490-8. PMID: 25159209, PMCID: PMC4197712, PII: iovs.14-14945, DOI: 10.1167/iovs.14-14945, ISSN: 1552-5783.
Capozzi ME, McCollum GW, Penn JS. The role of cytochrome P450 epoxygenases in retinal angiogenesis. Invest. Ophthalmol. Vis. Sci. 2014 Jul; 55(7): 4253-60. PMID: 24917142, PMCID: PMC4098062, PII: iovs.14-14216, DOI: 10.1167/iovs.14-14216, ISSN: 1552-5783.
Madamanchi A, Capozzi M, Geng L, Li Z, Friedman RD, Dickeson SK, Penn JS, Zutter MM. Mitigation of oxygen-induced retinopathy in a2ß1 integrin-deficient mice. Invest. Ophthalmol. Vis. Sci. 2014 Jul; 55(7): 4338-47. PMID: 24917135, PMCID: PMC4102391, PII: iovs.14-14061, DOI: 10.1167/iovs.14-14061, ISSN: 1552-5783.
Watkins WM, McCollum GW, Savage SR, Capozzi ME, Penn JS, Morrison DG. Hypoxia-induced expression of VEGF splice variants and protein in four retinal cell types. Exp. Eye Res [print-electronic]. 2013 Nov; 116: 240-6. PMID: 24076411, PMCID: PMC4256053, PII: S0014-4835(13)00280-7, DOI: 10.1016/j.exer.2013.09.014, ISSN: 1096-0007.
Bretz CA, Savage S, Capozzi M, Penn JS. The role of the NFAT signaling pathway in retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 2013 Oct; 54(10): 7020-7. PMID: 24052639, PMCID: PMC3809948, PII: iovs.13-12183, DOI: 10.1167/iovs.13-12183, ISSN: 1552-5783.
Capozzi ME, McCollum GW, Savage SR, Penn JS. Peroxisome proliferator-activated receptor-ß/d regulates angiogenic cell behaviors and oxygen-induced retinopathy. Invest. Ophthalmol. Vis. Sci. 2013 Jun; 54(6): 4197-207. PMID: 23716627, PMCID: PMC3687964, PII: iovs.13-11608, DOI: 10.1167/iovs.13-11608, ISSN: 1552-5783.
Capozzi ME, Gordon AY, Penn JS, Jayagopal A. Molecular imaging of retinal disease. J Ocul Pharmacol Ther [print-electronic]. 2013 Mar; 29(2): 275-86. PMID: 23421501, PMCID: PMC3601716, DOI: 10.1089/jop.2012.0279, ISSN: 1557-7732.
Barnett JM, Penn JS, Jayagopal A. Imaging of endothelial progenitor cell subpopulations in angiogenesis using quantum dot nanocrystals. Methods Mol. Biol. 2013; 1026: 45-56. PMID: 23749568, DOI: 10.1007/978-1-62703-468-5_4, ISSN: 1940-6029.
Palmer GM, Tiran Z, Zhou Z, Capozzi ME, Park W, Coletta C, Pyriochou A, Kliger Y, Levy O, Borukhov I, Dewhirst MW, Rotman G, Penn JS, Papapetropoulos A. A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol. 2012 Mar; 165(6): 1891-903. PMID: 21943108, PMCID: PMC3372838, DOI: 10.1111/j.1476-5381.2011.01677.x, ISSN: 1476-5381.
Rezaei KA, Toma HS, Cai J, Penn JS, Sternberg P, Kim SJ. Reduced choroidal neovascular membrane formation in cyclooxygenase-2 null mice. Invest. Ophthalmol. Vis. Sci [electronic-print]. 2011 Feb; 52(2): 701-7. PMID: 20881304, PMCID: PMC3053102, PII: iovs.10-6319, DOI: 10.1167/iovs.10-6319, ISSN: 1552-5783.
Toma HS, Barnett JM, Penn JS, Kim SJ. Improved assessment of laser-induced choroidal neovascularization. Microvasc. Res [print-electronic]. 2010 Dec; 80(3): 295-302. PMID: 20553963, PMCID: PMC3390000, PII: S0026-2862(10)00132-9, DOI: 10.1016/j.mvr.2010.05.011, ISSN: 1095-9319.
Kim SJ, Toma HS, Barnett JM, Penn JS. Ketorolac inhibits choroidal neovascularization by suppression of retinal VEGF. Exp. Eye Res [print-electronic]. 2010 Oct; 91(4): 537-43. PMID: 20659449, PMCID: PMC3389996, PII: S0014-4835(10)00222-8, DOI: 10.1016/j.exer.2010.07.011, ISSN: 1096-0007.
Yanni SE, McCollum GW, Penn JS. Genetic deletion of COX-2 diminishes VEGF production in mouse retinal Müller cells. Exp. Eye Res [print-electronic]. 2010 Jul; 91(1): 34-41. PMID: 20398651, PMCID: PMC2879458, PII: S0014-4835(10)00108-9, DOI: 10.1016/j.exer.2010.03.019, ISSN: 1096-0007.
Williams C, Kim SH, Ni TT, Mitchell L, Ro H, Penn JS, Baldwin SH, Solnica-Krezel L, Zhong TP. Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev. Biol [print-electronic]. 2010 May 5/1/2010; 341(1): 196-204. PMID: 20193674, PMCID: PMC3197743, PII: S0012-1606(10)00137-5, DOI: 10.1016/j.ydbio.2010.02.028, ISSN: 1095-564X.
Yanni SE, Clark ML, Yang R, Bingaman DP, Penn JS. The effects of nepafenac and amfenac on retinal angiogenesis. Brain Res. Bull [print-electronic]. 2010 Feb 2/15/2010; 81(2-3): 310-9. PMID: 19897019, PMCID: PMC2815002, PII: S0361-9230(09)00346-3, DOI: 10.1016/j.brainresbull.2009.10.018, ISSN: 1873-2747.
Recchia FM, Xu L, Penn JS, Boone B, Dexheimer PJ. Identification of genes and pathways involved in retinal neovascularization by microarray analysis of two animal models of retinal angiogenesis. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Feb; 51(2): 1098-105. PMID: 19834031, PMCID: PMC2868453, PII: iovs.09-4006, DOI: 10.1167/iovs.09-4006, ISSN: 1552-5783.
Barnett JM, McCollum GW, Penn JS. Role of cytosolic phospholipase A(2) in retinal neovascularization. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Feb; 51(2): 1136-42. PMID: 19661235, PMCID: PMC2868444, PII: iovs.09-3691, DOI: 10.1167/iovs.09-3691, ISSN: 1552-5783.
Barnett JM, Yanni SE, Penn JS. The development of the rat model of retinopathy of prematurity. Doc Ophthalmol [print-electronic]. 2010 Feb; 120(1): 3-12. PMID: 19639356, PMCID: PMC3752888, DOI: 10.1007/s10633-009-9180-y, ISSN: 1573-2622.
Yanni SE, Barnett JM, Clark ML, Penn JS. The role of PGE2 receptor EP4 in pathologic ocular angiogenesis. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2009 Nov; 50(11): 5479-86. PMID: 19494202, PMCID: PMC4071769, PII: iovs.09-3652, DOI: 10.1167/iovs.09-3652, ISSN: 1552-5783.
Zhao T, Wang D, Cheranov SY, Karpurapu M, Chava KR, Kundumani-Sridharan V, Johnson DA, Penn JS, Rao GN. A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis. J Lipid Res [print-electronic]. 2009 Mar; 50(3): 521-33. PMID: 18849464, PMCID: PMC2638108, PII: S0022-2275(20)30895-6, DOI: 10.1194/jlr.M800388-JLR200, ISSN: 0022-2275.
Penn JS, Madan A, Caldwell RB, Bartoli M, Caldwell RW, Hartnett ME. Vascular endothelial growth factor in eye disease. Prog Retin Eye Res [print-electronic]. 2008 Jul; 27(4): 331-71. PMID: 18653375, PMCID: PMC3682685, PII: S1350-9462(08)00034-7, DOI: 10.1016/j.preteyeres.2008.05.001, ISSN: 1350-9462.
Berkowitz BA, Roberts R, Penn JS, Gradianu M. High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2007 Oct; 48(10): 4733-40. PMID: 17898298, PII: 48/10/4733, DOI: 10.1167/iovs.06-1516, ISSN: 0146-0404.
Barnett JM, McCollum GW, Fowler JA, Duan JJ, Kay JD, Liu RQ, Bingaman DP, Penn JS. Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR. Invest. Ophthalmol. Vis. Sci. 2007 Feb; 48(2): 907-15. PMID: 17251494, PMCID: PMC2614400, PII: 48/2/907, DOI: 10.1167/iovs.06-0082, ISSN: 0146-0404.
Werdich XQ, Penn JS. Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 2006 Nov; 47(11): 5047-56. PMID: 17065526, PII: 47/11/5047, DOI: 10.1167/iovs.05-1343, ISSN: 0146-0404.
Penn JS, McCollum GW, Barnett JM, Werdich XQ, Koepke KA, Rajaratnam VS. Angiostatic effect of penetrating ocular injury: role of pigment epithelium-derived factor. Invest. Ophthalmol. Vis. Sci. 2006 Jan; 47(1): 405-14. PMID: 16384991, PII: 47/1/405, DOI: 10.1167/iovs.05-0673, ISSN: 0146-0404.
Chen, J., Hicks, D., Brantley-Sieders, D., Cheng, N., McCollum, G.W., Werdich, X.Q. and Penn, J.S.. Inhibition of Retinal Neovascularization by Soluble EphA2 Receptor. Exp. Eye Res. 2006; 82(4): 664-73.
Kramerov A.A., Saghizadeh M., Pan H., Kabosova A., Montenarh M., Ahmed K., Penn J.S., Chan C.K., Hinton D.R., Grant M.B. and Ljubimov A.V.. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006; 168(5): 1722-36.
Lutty G.A., Chan-Ling T., Phelps D.L., Adamis A.P., Berns K.I., Chan C.K., Cole C.H., D’Amore P.A., Das, A., Deng W-T., Dobson V., Flynn J.T., Friedlander M., Fulton A., Good W.V., Grant, M.B., Hansen R., Hauswirth W.V., Hardy R.J., Hinton D.R., Hughes S., McLeod D.S., Palmer E.A., Patz A., Penn J.S., Raisler B.J., Repka M.X., Saint-Geniez M., Shaw L.C., Shima D.T., Smith B.T., Smith L.E.H., Tahija S.G., Tasman W., Trese M.T.. Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery. Molecular Vision. 2006; 12: 532-80.
Werdich XQ, Penn JS. Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events. Angiogenesis [print-electronic]. 2005; 8(4): 315-26. PMID: 16400523, DOI: 10.1007/s10456-005-9021-x, ISSN: 0969-6970.
Werdich XQ, McCollum GW, Rajaratnam VS, Penn JS. Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygen-induced retinopathy. Exp. Eye Res. 2004 Nov; 79(5): 623-30. PMID: 15500821, PII: S0014-4835(04)00199-X, DOI: 10.1016/j.exer.2004.07.006, ISSN: 0014-4835.
McCollum GW, Rajaratnam VS, Bullard LE, Yang R, Penn JS. Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp. Eye Res. 2004 May; 78(5): 987-95. PMID: 15051479, PII: S0014483504000065, DOI: 10.1016/j.exer.2003.12.008, ISSN: 0014-4835.
York JR, Landers S, Kirby RS, Arbogast PG, Penn JS. Arterial oxygen fluctuation and retinopathy of prematurity in very-low-birth-weight infants. J Perinatol. 2004 Feb; 24(2): 82-7. PMID: 14762452, PII: 7211040, DOI: 10.1038/sj.jp.7211040, ISSN: 0743-8346.
Anderson, R.E. and Penn, J.S.. Environmental light and heredity provoke adaptive changes in retinal DHA levels that affect retinal function. Lipids. 2004; 39(11): 1121-4.
Penn JS, Rajaratnam VS. Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2003 Dec; 44(12): 5423-9. PMID: 14638747, ISSN: 0146-0404.
Bullard LE, Qi X, Penn JS. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest. Ophthalmol. Vis. Sci. 2003 Apr; 44(4): 1722-31. PMID: 12657614, ISSN: 0146-0404.
Penn JS, Rajaratnam VS, Collier RJ, Clark AF. The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2001 Jan; 42(1): 283-90. PMID: 11133880, ISSN: 0146-0404.
Penn JS, Li S, Naash MI. Ambient hypoxia reverses retinal vascular attenuation in a transgenic mouse model of autosomal dominant retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2000 Nov; 41(12): 4007-13. PMID: 11053306, ISSN: 0146-0404.
Shafiee A, Roberts DD, Penn JS, Blake DA. Thrombospondin (TSP) peptides inhibit angiogenesis in retinal explant assay and rat model of retinopathy of prematurity. Invest. 2000; 41: 2378-88.
Berkowitz BA, Penn JS. Abnormal panretinal response pattern to carbogen inhalation in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998 Apr; 39(5): 840-5. PMID: 9538894, ISSN: 0146-0404.
Berkowitz BA, Roberto KA, Penn JS. The vitreous protein concentration is increased prior to neovascularization in experimental ROP. Curr. Eye Res. 1998 Feb; 17(2): 218-21. PMID: 9523102, ISSN: 0271-3683.
Berkowitz BA, Lukaszew RA, Mullins CM, Penn JS. Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998 Feb; 39(2): 391-6. PMID: 9477999, ISSN: 0146-0404.
Robbins, S.G., Rajaratnam, V.S. and Penn, J.S. Evidence for upregulation and redistribution of vascular endothelial growth factor receptors flt-1 and flk-1 in the oxygen-injured rat retina. Growth Factors. 1998; 16: 1-9.
Berkowitz, B.A., R.A. Lukaszew, C.M. Mullins and J.S. Penn. Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998; 39((2)): 391-6.
Berkowitz, B.A., K.A. Roberto and J.S. Penn. The vitreous protein concentration is increased prior to neovascularization in experimental ROP. Curr. Eye Res. 1998; 17: 218-21.
Berkowitz, B.A. and J.S. Penn. Abnormal panretinal response pattern to carbogen inhalation in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998; 39((5)): 838-43.
Robbins, S.G., Conaway, J.R., Tolman, B.L., Roberto, K.A. and Penn, J.S. Detection of vascular endothelial growth factor (VEGF) protein in vascular and non-vascular cells of the normal and oxygen-injured rat retina. Growth Factors. 1997; 14((4)): 279-95.
Niesman MR, Johnson KA, and Penn JS. Therapeutic effect of liposomal superoxide dismutase in an animal model of retinopathy of prematurity. Neurochem. Res. 1997; 22((5)): 597-605.
Kommonen, B.W., U. Karhunen, T. Kylma, W.W. Dawson and J.S. Penn. Impaired retinal function in young labrador retriever dogs heterozygous for late-onset rod-cone degeneration. Vis. Res. 1997; 37((3)): 365-70.
Penn, J.S., Tolman, B.L. and L.E. Bullard. Effect of a water soluble vitamin E analogue,Trolox, on retinal vascular development in an animal model of retinopathy of prematurity. Free Rad. Biol. Med. 1997; 22((6)): 977-84.
Penn, J.S. and M.M. Henry. Assessing retinal neovascularization in an animal model of proliferative retinopathy. Microvasc. Res. 1996; 51: 126-30.
Penn, J.S. and M.M. Henry. Evaluation of blood vessel assessment techniques in animals with retinal vascular disease. J. Ophthal. Phot. 1996; 18: 26-33.
Kommonen, B.W., T. Kylma, R.J. Cohen, J.S. Penn, L. Paulin, M.Y. Hurwitz and R.L. Hurwitz. Early changes in cyclic GMP levels and ultrastructure in photoreceptor degeneration in Labrador Retrievers. Ophthalmic Res. 1996; 28((1)): 19-28.
Roberto, K.A., B.L. Tolman and J.S. Penn. Long-term retinal vascular abnormalities in an animal model of retinopathy of prematurity. Cur. Eye Res. 1996; 15: 932-7.
Penn JS, Henry MM, Tolman BL and Wall PT. The range of PaO2 variation determines the severity of oxygen-induced retinopathy in newborn rats. Invest. Ophthalmol. Vis. Sci. 1995; (10)((36)): 2063-70.
Penn, J.S., B.L. Tolman, and M.M. Henry. Oxygen-induced retinopathy in the rat: relationship of retinal non-perfusion to subsequent neovascularization. 35Invest. Ophthalmol. Vis. Sci. 1994; (9): 3429-35.
Kommonen, B.W., J.S.Penn, T. Kylma, U. Karhunen, W.W. Dawson, B.L. Tolman, and T. Ukkola. Early morphometry of a retinal dystrophy in Labrador Retrievers. Acta Ophthalmologica. 1994; 72: 203-10.
Penn, J.S., M.M. Henry and B.L. Tolman. Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat. Pediatr. Res. 1994; 36((6)): 724-31.
Penn, J.S., B.L. Tolman and L.A. Lowery. Variable oxygen exposure causes pre-retinal neovascularization in the newborn rat. Invest. Ophthalmol. Vis. Sci. 1993; 34((3)): 576-85.
Penn, J.S. and B.D. Johnson. Fluorescein angiography as a means of assessing retinal vascular pathology in oxygen-exposed newborn rats. Curr. Eye Res. 1993; 12((6)): 561-70.
Penn, J.S. and C.A. Gay. A new method of vascular analysis for animal models of retinopathy of prematurity. Exp. Eye Res. 1992; 54: 329-36.
Penn, J.S., L.A. Thum and M.I. Naash. Oxygen-induced retinopathy in the rat: Vitamins C and E as potential therapies. Invest. Ophthalmol. Vis. Sci. 1992; 33((6)): 1836-45.
Penn, J.S., B.L. Tolman, C.A. Koutz and L.A. Lowery. Oxygen-induced retinopathy in the rat: Hemorrhages and dysplasias may lead to retinal detachments. Cur. Eye Res. 1992; 11((10)): 939-53.
Penn, J.S., B.L. Tolman, L.A. Thum and C.A. Koutz. Effect of light history on the rat retina: Timecourse of morphological adaptation and readaptation. Neurochem. Res. 1991; 17((1)): 91-9.
Penn, J.S. Oxygen-induced retinopathy in the rat: Possible contribution of peroxidation reactions. Doc. Ophthalmol. 1990; 74: 179-86.
Larrazabal, L.I. and J.S. Penn. Fluorescein angiography in the newborn rat: Implications in oxygen-induced retinopathy. Invest. Ophthalmol. Vis. Sci. 1990; 31((5)): 810-8.
Williams, T.P., J.S. Penn, R.A. Bush, and C.L. Makino. Renewal of rod outer segments and regulation of daily photon catch by the rat retina. Pro. Yamada Conf. 1989; 255-60.
Penn, J.S. and L.A. Thum. Oxygen-induced retinopathy in the rat: Role of vitamin E in defending against peroxidation. Ann. N.Y. Acad. Sci. 1989; 495-7.
Penn, J.S., L.A. Thum and M.I. Naash. Photoreceptor physiology in the rat is governed by the light environment. Exp. Eye Res. 1989; 49((2)): 205-15.
Larrazabal, L.I. and J.S. Penn. Study of ocular vasculature in the newborn rat by fluorescein angiography. J. Ophthal. Phot. 1989; 11((2)): 49-52.
Penn, J.S., L.A. Thum, M. Rhem, and S.J. Dell. Effects of oxygen-rearing on the electroretinogram and GFA-protein in the rat. Invest. Ophthalmol. Vis. Sci. 1988; 29((11)): 1623-30.
Giblin MJ, Ontko CD, Penn JS. Effect of cytokine-induced alterations in extracellular matrix composition on diabetic retinopathy-relevant endothelial cell behaviors. Sci Rep. 2022 Jul 7/28/2022; 12(1): 12955. PMID: 35902594, PMCID: PMC9334268, PII: 10.1038/s41598-022-12683-7, DOI: 10.1038/s41598-022-12683-7, ISSN: 2045-2322.
Paguaga ME, Penn JS, Uddin MI. A novel optical imaging probe for targeted visualization of NLRP3 inflammasomes in a mouse model of age-related macular degeneration. Front Med (Lausanne). 2022; 9: 1047791. PMID: 36703888, PMCID: PMC9871584, DOI: 10.3389/fmed.2022.1047791, ISSN: 2296-858X.
Giblin MJ, Smith TE, Winkler G, Pendergrass HA, Kim MJ, Capozzi ME, Yang R, McCollum GW, Penn JS. Nuclear factor of activated T-cells (NFAT) regulation of IL-1ß-induced retinal vascular inflammation. Biochim Biophys Acta Mol Basis Dis [print-electronic]. 2021 Dec 12/1/2021; 1867(12): 166238. PMID: 34343639, PMCID: PMC8565496, PII: S0925-4439(21)00171-X, DOI: 10.1016/j.bbadis.2021.166238, ISSN: 1879-260X.
Ontko CD, Capozzi ME, Kim MJ, McCollum GW, Penn JS. Cytochrome P450-epoxygenated fatty acids inhibit Müller glial inflammation. Sci Rep. 2021 May 5/6/2021; 11(1): 9677. PMID: 33958662, PMCID: PMC8102485, PII: 10.1038/s41598-021-89000-1, DOI: 10.1038/s41598-021-89000-1, ISSN: 2045-2322.
Uddin MI, Kilburn TC, Jamal SZ, Duvall CL, Penn JS. A novel method for visualizing and tracking endogenous mRNA in a specific cell population in pathological neovascularization. Sci Rep. 2021 Jan 1/28/2021; 11(1): 2565. PMID: 33510218, PMCID: PMC7844016, PII: 10.1038/s41598-021-81367-5, DOI: 10.1038/s41598-021-81367-5, ISSN: 2045-2322.
Uddin MI, Kilburn TC, Duvall CL, Penn JS. Visualizing HIF-1a mRNA in a Subpopulation of Bone Marrow-Derived Cells to Predict Retinal Neovascularization. ACS Chem Biol [print-electronic]. 2020 Nov 11/20/2020; 15(11): 3004-12. PMID: 33080135, PMCID: PMC8121337, DOI: 10.1021/acschembio.0c00662, ISSN: 1554-8937.
Capozzi ME, Savage SR, McCollum GW, Hammer SS, Ramos CJ, Yang R, Bretz CA, Penn JS. The peroxisome proliferator-activated receptor-ß/d antagonist GSK0660 mitigates retinal cell inflammation and leukostasis. Exp Eye Res [print-electronic]. 2020 Jan; 190: 107885. PMID: 31758977, PMCID: PMC7426872, PII: S0014-4835(19)30521-4, DOI: 10.1016/j.exer.2019.107885, ISSN: 1096-0007.
Cao J, Yang R, Smith TE, Evans S, McCollum GW, Pomerantz SC, Petley T, Harris IR, Penn JS. Human Umbilical Tissue-Derived Cells Secrete Soluble VEGFR1 and Inhibit Choroidal Neovascularization. Mol Ther Methods Clin Dev. 2019 Sep 9/13/2019; 14: 37-46. PMID: 31276010, PMCID: PMC6586593, PII: S2329-0501(19)30051-8, DOI: 10.1016/j.omtm.2019.05.007, ISSN: 2329-0501.
Gordon AY, Lapierre-Landry M, Skala MC, Penn JS. Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents. Transl Vis Sci Technol. 2019 May; 8(3): 18. PMID: 31131155, PMCID: PMC6519216, PII: TVST-18-1100, DOI: 10.1167/tvst.8.3.18, ISSN: 2164-2591.
Uddin MI, Kilburn TC, Yang R, McCollum GW, Wright DW, Penn JS. Targeted Imaging of VCAM-1 mRNA in a Mouse Model of Laser-Induced Choroidal Neovascularization Using Antisense Hairpin-DNA-Functionalized Gold-Nanoparticles. Mol Pharm [print-electronic]. 2018 Dec 12/3/2018; 15(12): 5514-20. PMID: 30350640, PMCID: PMC7135968, DOI: 10.1021/acs.molpharmaceut.8b00661, ISSN: 1543-8392.
Capozzi ME, Giblin MJ, Penn JS. Palmitic Acid Induces Müller Cell Inflammation that is Potentiated by Co-treatment with Glucose. Sci Rep. 2018 Apr 4/3/2018; 8(1): 5459. PMID: 29626212, PMCID: PMC5889388, PII: 10.1038/s41598-018-23601-1, DOI: 10.1038/s41598-018-23601-1, ISSN: 2045-2322.
Uddin MI, Jayagopal A, Wong A, McCollum GW, Wright DW, Penn JS. Real-time imaging of VCAM-1 mRNA in TNF-a activated retinal microvascular endothelial cells using antisense hairpin-DNA functionalized gold nanoparticles. Nanomedicine [print-electronic]. 2018 Jan; 14(1): 63-71. PMID: 28890107, PMCID: PMC5742066, PII: S1549-9634(17)30165-X, DOI: 10.1016/j.nano.2017.08.018, ISSN: 1549-9642.
Lapierre-Landry M, Gordon AY, Penn JS, Skala MC. In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye. Sci Rep. 2017 Aug 8/23/2017; 7(1): 9228. PMID: 28835698, PMCID: PMC5569082, PII: 10.1038/s41598-017-10050-5, DOI: 10.1038/s41598-017-10050-5, ISSN: 2045-2322.
Uddin MI, Jayagopal A, McCollum GW, Yang R, Penn JS. In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO). Invest Ophthalmol Vis Sci. 2017 Jul 7/1/2017; 58(9): 3818-24. PMID: 28750413, PMCID: PMC5531786, PII: 2646756, DOI: 10.1167/iovs.16-21187, ISSN: 1552-5783.
Uddin MI, Evans SM, Craft JR, Capozzi ME, McCollum GW, Yang R, Marnett LJ, Uddin MJ, Jayagopal A, Penn JS. In Vivo Imaging of Retinal Hypoxia in a Model of Oxygen-Induced Retinopathy. Sci Rep. 2016 Aug 8/5/2016; 6: 31011. PMID: 27491345, PMCID: PMC4974503, PII: srep31011, DOI: 10.1038/srep31011, ISSN: 2045-2322.
Suarez S, McCollum GW, Jayagopal A, Penn JS. High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1. J. Biol. Chem [print-electronic]. 2015 Nov 11/20/2015; 290(47): 28311-20. PMID: 26438826, PMCID: PMC4653686, PII: M115.682385, DOI: 10.1074/jbc.M115.682385, ISSN: 1083-351X.
Savage SR, McCollum GW, Yang R, Penn JS. RNA-seq identifies a role for the PPARß/d inverse agonist GSK0660 in the regulation of TNFa-induced cytokine signaling in retinal endothelial cells. Mol. Vis. 2015; 21: 568-76. PMID: 26015769, PMCID: PMC4443583, ISSN: 1090-0535.
Savage SR, Bretz CA, Penn JS. RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFa. PLoS ONE. 2015; 10(1): e0116941. PMID: 25617622, PMCID: PMC4305319, PII: PONE-D-14-43273, DOI: 10.1371/journal.pone.0116941, ISSN: 1932-6203.
Bretz CA, Savage SR, Capozzi ME, Suarez S, Penn JS. NFAT isoforms play distinct roles in TNFa-induced retinal leukostasis. Sci Rep. 2015; 5: 14963. PMID: 26527057, PMCID: PMC4630625, PII: srep14963, DOI: 10.1038/srep14963, ISSN: 2045-2322.
Suarez S, McCollum GW, Bretz CA, Yang R, Capozzi ME, Penn JS. Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-ß/d. Invest. Ophthalmol. Vis. Sci. 2014 Dec; 55(12): 8232-40. PMID: 25406289, PMCID: PMC4271638, PII: iovs.14-14217, DOI: 10.1167/iovs.14-14217, ISSN: 1552-5783.
Barnett JM, Suarez S, McCollum GW, Penn JS. Endoglin promotes angiogenesis in cell- and animal-based models of retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 2014 Oct; 55(10): 6490-8. PMID: 25159209, PMCID: PMC4197712, PII: iovs.14-14945, DOI: 10.1167/iovs.14-14945, ISSN: 1552-5783.
Capozzi ME, McCollum GW, Penn JS. The role of cytochrome P450 epoxygenases in retinal angiogenesis. Invest. Ophthalmol. Vis. Sci. 2014 Jul; 55(7): 4253-60. PMID: 24917142, PMCID: PMC4098062, PII: iovs.14-14216, DOI: 10.1167/iovs.14-14216, ISSN: 1552-5783.
Madamanchi A, Capozzi M, Geng L, Li Z, Friedman RD, Dickeson SK, Penn JS, Zutter MM. Mitigation of oxygen-induced retinopathy in a2ß1 integrin-deficient mice. Invest. Ophthalmol. Vis. Sci. 2014 Jul; 55(7): 4338-47. PMID: 24917135, PMCID: PMC4102391, PII: iovs.14-14061, DOI: 10.1167/iovs.14-14061, ISSN: 1552-5783.
Watkins WM, McCollum GW, Savage SR, Capozzi ME, Penn JS, Morrison DG. Hypoxia-induced expression of VEGF splice variants and protein in four retinal cell types. Exp. Eye Res [print-electronic]. 2013 Nov; 116: 240-6. PMID: 24076411, PMCID: PMC4256053, PII: S0014-4835(13)00280-7, DOI: 10.1016/j.exer.2013.09.014, ISSN: 1096-0007.
Bretz CA, Savage S, Capozzi M, Penn JS. The role of the NFAT signaling pathway in retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 2013 Oct; 54(10): 7020-7. PMID: 24052639, PMCID: PMC3809948, PII: iovs.13-12183, DOI: 10.1167/iovs.13-12183, ISSN: 1552-5783.
Capozzi ME, McCollum GW, Savage SR, Penn JS. Peroxisome proliferator-activated receptor-ß/d regulates angiogenic cell behaviors and oxygen-induced retinopathy. Invest. Ophthalmol. Vis. Sci. 2013 Jun; 54(6): 4197-207. PMID: 23716627, PMCID: PMC3687964, PII: iovs.13-11608, DOI: 10.1167/iovs.13-11608, ISSN: 1552-5783.
Capozzi ME, Gordon AY, Penn JS, Jayagopal A. Molecular imaging of retinal disease. J Ocul Pharmacol Ther [print-electronic]. 2013 Mar; 29(2): 275-86. PMID: 23421501, PMCID: PMC3601716, DOI: 10.1089/jop.2012.0279, ISSN: 1557-7732.
Barnett JM, Penn JS, Jayagopal A. Imaging of endothelial progenitor cell subpopulations in angiogenesis using quantum dot nanocrystals. Methods Mol. Biol. 2013; 1026: 45-56. PMID: 23749568, DOI: 10.1007/978-1-62703-468-5_4, ISSN: 1940-6029.
Palmer GM, Tiran Z, Zhou Z, Capozzi ME, Park W, Coletta C, Pyriochou A, Kliger Y, Levy O, Borukhov I, Dewhirst MW, Rotman G, Penn JS, Papapetropoulos A. A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. Br J Pharmacol. 2012 Mar; 165(6): 1891-903. PMID: 21943108, PMCID: PMC3372838, DOI: 10.1111/j.1476-5381.2011.01677.x, ISSN: 1476-5381.
Rezaei KA, Toma HS, Cai J, Penn JS, Sternberg P, Kim SJ. Reduced choroidal neovascular membrane formation in cyclooxygenase-2 null mice. Invest. Ophthalmol. Vis. Sci [electronic-print]. 2011 Feb; 52(2): 701-7. PMID: 20881304, PMCID: PMC3053102, PII: iovs.10-6319, DOI: 10.1167/iovs.10-6319, ISSN: 1552-5783.
Toma HS, Barnett JM, Penn JS, Kim SJ. Improved assessment of laser-induced choroidal neovascularization. Microvasc. Res [print-electronic]. 2010 Dec; 80(3): 295-302. PMID: 20553963, PMCID: PMC3390000, PII: S0026-2862(10)00132-9, DOI: 10.1016/j.mvr.2010.05.011, ISSN: 1095-9319.
Kim SJ, Toma HS, Barnett JM, Penn JS. Ketorolac inhibits choroidal neovascularization by suppression of retinal VEGF. Exp. Eye Res [print-electronic]. 2010 Oct; 91(4): 537-43. PMID: 20659449, PMCID: PMC3389996, PII: S0014-4835(10)00222-8, DOI: 10.1016/j.exer.2010.07.011, ISSN: 1096-0007.
Yanni SE, McCollum GW, Penn JS. Genetic deletion of COX-2 diminishes VEGF production in mouse retinal Müller cells. Exp. Eye Res [print-electronic]. 2010 Jul; 91(1): 34-41. PMID: 20398651, PMCID: PMC2879458, PII: S0014-4835(10)00108-9, DOI: 10.1016/j.exer.2010.03.019, ISSN: 1096-0007.
Williams C, Kim SH, Ni TT, Mitchell L, Ro H, Penn JS, Baldwin SH, Solnica-Krezel L, Zhong TP. Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Dev. Biol [print-electronic]. 2010 May 5/1/2010; 341(1): 196-204. PMID: 20193674, PMCID: PMC3197743, PII: S0012-1606(10)00137-5, DOI: 10.1016/j.ydbio.2010.02.028, ISSN: 1095-564X.
Yanni SE, Clark ML, Yang R, Bingaman DP, Penn JS. The effects of nepafenac and amfenac on retinal angiogenesis. Brain Res. Bull [print-electronic]. 2010 Feb 2/15/2010; 81(2-3): 310-9. PMID: 19897019, PMCID: PMC2815002, PII: S0361-9230(09)00346-3, DOI: 10.1016/j.brainresbull.2009.10.018, ISSN: 1873-2747.
Recchia FM, Xu L, Penn JS, Boone B, Dexheimer PJ. Identification of genes and pathways involved in retinal neovascularization by microarray analysis of two animal models of retinal angiogenesis. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Feb; 51(2): 1098-105. PMID: 19834031, PMCID: PMC2868453, PII: iovs.09-4006, DOI: 10.1167/iovs.09-4006, ISSN: 1552-5783.
Barnett JM, McCollum GW, Penn JS. Role of cytosolic phospholipase A(2) in retinal neovascularization. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Feb; 51(2): 1136-42. PMID: 19661235, PMCID: PMC2868444, PII: iovs.09-3691, DOI: 10.1167/iovs.09-3691, ISSN: 1552-5783.
Barnett JM, Yanni SE, Penn JS. The development of the rat model of retinopathy of prematurity. Doc Ophthalmol [print-electronic]. 2010 Feb; 120(1): 3-12. PMID: 19639356, PMCID: PMC3752888, DOI: 10.1007/s10633-009-9180-y, ISSN: 1573-2622.
Yanni SE, Barnett JM, Clark ML, Penn JS. The role of PGE2 receptor EP4 in pathologic ocular angiogenesis. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2009 Nov; 50(11): 5479-86. PMID: 19494202, PMCID: PMC4071769, PII: iovs.09-3652, DOI: 10.1167/iovs.09-3652, ISSN: 1552-5783.
Zhao T, Wang D, Cheranov SY, Karpurapu M, Chava KR, Kundumani-Sridharan V, Johnson DA, Penn JS, Rao GN. A novel role for activating transcription factor-2 in 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis. J Lipid Res [print-electronic]. 2009 Mar; 50(3): 521-33. PMID: 18849464, PMCID: PMC2638108, PII: S0022-2275(20)30895-6, DOI: 10.1194/jlr.M800388-JLR200, ISSN: 0022-2275.
Penn JS, Madan A, Caldwell RB, Bartoli M, Caldwell RW, Hartnett ME. Vascular endothelial growth factor in eye disease. Prog Retin Eye Res [print-electronic]. 2008 Jul; 27(4): 331-71. PMID: 18653375, PMCID: PMC3682685, PII: S1350-9462(08)00034-7, DOI: 10.1016/j.preteyeres.2008.05.001, ISSN: 1350-9462.
Berkowitz BA, Roberts R, Penn JS, Gradianu M. High-resolution manganese-enhanced MRI of experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2007 Oct; 48(10): 4733-40. PMID: 17898298, PII: 48/10/4733, DOI: 10.1167/iovs.06-1516, ISSN: 0146-0404.
Barnett JM, McCollum GW, Fowler JA, Duan JJ, Kay JD, Liu RQ, Bingaman DP, Penn JS. Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR. Invest. Ophthalmol. Vis. Sci. 2007 Feb; 48(2): 907-15. PMID: 17251494, PMCID: PMC2614400, PII: 48/2/907, DOI: 10.1167/iovs.06-0082, ISSN: 0146-0404.
Werdich XQ, Penn JS. Specific involvement of SRC family kinase activation in the pathogenesis of retinal neovascularization. Invest. Ophthalmol. Vis. Sci. 2006 Nov; 47(11): 5047-56. PMID: 17065526, PII: 47/11/5047, DOI: 10.1167/iovs.05-1343, ISSN: 0146-0404.
Penn JS, McCollum GW, Barnett JM, Werdich XQ, Koepke KA, Rajaratnam VS. Angiostatic effect of penetrating ocular injury: role of pigment epithelium-derived factor. Invest. Ophthalmol. Vis. Sci. 2006 Jan; 47(1): 405-14. PMID: 16384991, PII: 47/1/405, DOI: 10.1167/iovs.05-0673, ISSN: 0146-0404.
Chen, J., Hicks, D., Brantley-Sieders, D., Cheng, N., McCollum, G.W., Werdich, X.Q. and Penn, J.S.. Inhibition of Retinal Neovascularization by Soluble EphA2 Receptor. Exp. Eye Res. 2006; 82(4): 664-73.
Kramerov A.A., Saghizadeh M., Pan H., Kabosova A., Montenarh M., Ahmed K., Penn J.S., Chan C.K., Hinton D.R., Grant M.B. and Ljubimov A.V.. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006; 168(5): 1722-36.
Lutty G.A., Chan-Ling T., Phelps D.L., Adamis A.P., Berns K.I., Chan C.K., Cole C.H., D’Amore P.A., Das, A., Deng W-T., Dobson V., Flynn J.T., Friedlander M., Fulton A., Good W.V., Grant, M.B., Hansen R., Hauswirth W.V., Hardy R.J., Hinton D.R., Hughes S., McLeod D.S., Palmer E.A., Patz A., Penn J.S., Raisler B.J., Repka M.X., Saint-Geniez M., Shaw L.C., Shima D.T., Smith B.T., Smith L.E.H., Tahija S.G., Tasman W., Trese M.T.. Proceedings of the Third International Symposium on Retinopathy of Prematurity: An update on ROP from the lab to the nursery. Molecular Vision. 2006; 12: 532-80.
Werdich XQ, Penn JS. Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events. Angiogenesis [print-electronic]. 2005; 8(4): 315-26. PMID: 16400523, DOI: 10.1007/s10456-005-9021-x, ISSN: 0969-6970.
Werdich XQ, McCollum GW, Rajaratnam VS, Penn JS. Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygen-induced retinopathy. Exp. Eye Res. 2004 Nov; 79(5): 623-30. PMID: 15500821, PII: S0014-4835(04)00199-X, DOI: 10.1016/j.exer.2004.07.006, ISSN: 0014-4835.
McCollum GW, Rajaratnam VS, Bullard LE, Yang R, Penn JS. Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity. Exp. Eye Res. 2004 May; 78(5): 987-95. PMID: 15051479, PII: S0014483504000065, DOI: 10.1016/j.exer.2003.12.008, ISSN: 0014-4835.
York JR, Landers S, Kirby RS, Arbogast PG, Penn JS. Arterial oxygen fluctuation and retinopathy of prematurity in very-low-birth-weight infants. J Perinatol. 2004 Feb; 24(2): 82-7. PMID: 14762452, PII: 7211040, DOI: 10.1038/sj.jp.7211040, ISSN: 0743-8346.
Anderson, R.E. and Penn, J.S.. Environmental light and heredity provoke adaptive changes in retinal DHA levels that affect retinal function. Lipids. 2004; 39(11): 1121-4.
Penn JS, Rajaratnam VS. Inhibition of retinal neovascularization by intravitreal injection of human rPAI-1 in a rat model of retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2003 Dec; 44(12): 5423-9. PMID: 14638747, ISSN: 0146-0404.
Bullard LE, Qi X, Penn JS. Role for extracellular signal-responsive kinase-1 and -2 in retinal angiogenesis. Invest. Ophthalmol. Vis. Sci. 2003 Apr; 44(4): 1722-31. PMID: 12657614, ISSN: 0146-0404.
Penn JS, Rajaratnam VS, Collier RJ, Clark AF. The effect of an angiostatic steroid on neovascularization in a rat model of retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2001 Jan; 42(1): 283-90. PMID: 11133880, ISSN: 0146-0404.
Penn JS, Li S, Naash MI. Ambient hypoxia reverses retinal vascular attenuation in a transgenic mouse model of autosomal dominant retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 2000 Nov; 41(12): 4007-13. PMID: 11053306, ISSN: 0146-0404.
Shafiee A, Roberts DD, Penn JS, Blake DA. Thrombospondin (TSP) peptides inhibit angiogenesis in retinal explant assay and rat model of retinopathy of prematurity. Invest. 2000; 41: 2378-88.
Berkowitz BA, Penn JS. Abnormal panretinal response pattern to carbogen inhalation in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998 Apr; 39(5): 840-5. PMID: 9538894, ISSN: 0146-0404.
Berkowitz BA, Roberto KA, Penn JS. The vitreous protein concentration is increased prior to neovascularization in experimental ROP. Curr. Eye Res. 1998 Feb; 17(2): 218-21. PMID: 9523102, ISSN: 0271-3683.
Berkowitz BA, Lukaszew RA, Mullins CM, Penn JS. Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998 Feb; 39(2): 391-6. PMID: 9477999, ISSN: 0146-0404.
Robbins, S.G., Rajaratnam, V.S. and Penn, J.S. Evidence for upregulation and redistribution of vascular endothelial growth factor receptors flt-1 and flk-1 in the oxygen-injured rat retina. Growth Factors. 1998; 16: 1-9.
Berkowitz, B.A., R.A. Lukaszew, C.M. Mullins and J.S. Penn. Impaired hyaloidal circulation function and uncoordinated ocular growth patterns in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998; 39((2)): 391-6.
Berkowitz, B.A., K.A. Roberto and J.S. Penn. The vitreous protein concentration is increased prior to neovascularization in experimental ROP. Curr. Eye Res. 1998; 17: 218-21.
Berkowitz, B.A. and J.S. Penn. Abnormal panretinal response pattern to carbogen inhalation in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 1998; 39((5)): 838-43.
Robbins, S.G., Conaway, J.R., Tolman, B.L., Roberto, K.A. and Penn, J.S. Detection of vascular endothelial growth factor (VEGF) protein in vascular and non-vascular cells of the normal and oxygen-injured rat retina. Growth Factors. 1997; 14((4)): 279-95.
Niesman MR, Johnson KA, and Penn JS. Therapeutic effect of liposomal superoxide dismutase in an animal model of retinopathy of prematurity. Neurochem. Res. 1997; 22((5)): 597-605.
Kommonen, B.W., U. Karhunen, T. Kylma, W.W. Dawson and J.S. Penn. Impaired retinal function in young labrador retriever dogs heterozygous for late-onset rod-cone degeneration. Vis. Res. 1997; 37((3)): 365-70.
Penn, J.S., Tolman, B.L. and L.E. Bullard. Effect of a water soluble vitamin E analogue,Trolox, on retinal vascular development in an animal model of retinopathy of prematurity. Free Rad. Biol. Med. 1997; 22((6)): 977-84.
Penn, J.S. and M.M. Henry. Assessing retinal neovascularization in an animal model of proliferative retinopathy. Microvasc. Res. 1996; 51: 126-30.
Penn, J.S. and M.M. Henry. Evaluation of blood vessel assessment techniques in animals with retinal vascular disease. J. Ophthal. Phot. 1996; 18: 26-33.
Kommonen, B.W., T. Kylma, R.J. Cohen, J.S. Penn, L. Paulin, M.Y. Hurwitz and R.L. Hurwitz. Early changes in cyclic GMP levels and ultrastructure in photoreceptor degeneration in Labrador Retrievers. Ophthalmic Res. 1996; 28((1)): 19-28.
Roberto, K.A., B.L. Tolman and J.S. Penn. Long-term retinal vascular abnormalities in an animal model of retinopathy of prematurity. Cur. Eye Res. 1996; 15: 932-7.
Penn JS, Henry MM, Tolman BL and Wall PT. The range of PaO2 variation determines the severity of oxygen-induced retinopathy in newborn rats. Invest. Ophthalmol. Vis. Sci. 1995; (10)((36)): 2063-70.
Penn, J.S., B.L. Tolman, and M.M. Henry. Oxygen-induced retinopathy in the rat: relationship of retinal non-perfusion to subsequent neovascularization. 35Invest. Ophthalmol. Vis. Sci. 1994; (9): 3429-35.
Kommonen, B.W., J.S.Penn, T. Kylma, U. Karhunen, W.W. Dawson, B.L. Tolman, and T. Ukkola. Early morphometry of a retinal dystrophy in Labrador Retrievers. Acta Ophthalmologica. 1994; 72: 203-10.
Penn, J.S., M.M. Henry and B.L. Tolman. Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat. Pediatr. Res. 1994; 36((6)): 724-31.
Penn, J.S., B.L. Tolman and L.A. Lowery. Variable oxygen exposure causes pre-retinal neovascularization in the newborn rat. Invest. Ophthalmol. Vis. Sci. 1993; 34((3)): 576-85.
Penn, J.S. and B.D. Johnson. Fluorescein angiography as a means of assessing retinal vascular pathology in oxygen-exposed newborn rats. Curr. Eye Res. 1993; 12((6)): 561-70.
Penn, J.S. and C.A. Gay. A new method of vascular analysis for animal models of retinopathy of prematurity. Exp. Eye Res. 1992; 54: 329-36.
Penn, J.S., L.A. Thum and M.I. Naash. Oxygen-induced retinopathy in the rat: Vitamins C and E as potential therapies. Invest. Ophthalmol. Vis. Sci. 1992; 33((6)): 1836-45.
Penn, J.S., B.L. Tolman, C.A. Koutz and L.A. Lowery. Oxygen-induced retinopathy in the rat: Hemorrhages and dysplasias may lead to retinal detachments. Cur. Eye Res. 1992; 11((10)): 939-53.
Penn, J.S., B.L. Tolman, L.A. Thum and C.A. Koutz. Effect of light history on the rat retina: Timecourse of morphological adaptation and readaptation. Neurochem. Res. 1991; 17((1)): 91-9.
Penn, J.S. Oxygen-induced retinopathy in the rat: Possible contribution of peroxidation reactions. Doc. Ophthalmol. 1990; 74: 179-86.
Larrazabal, L.I. and J.S. Penn. Fluorescein angiography in the newborn rat: Implications in oxygen-induced retinopathy. Invest. Ophthalmol. Vis. Sci. 1990; 31((5)): 810-8.
Williams, T.P., J.S. Penn, R.A. Bush, and C.L. Makino. Renewal of rod outer segments and regulation of daily photon catch by the rat retina. Pro. Yamada Conf. 1989; 255-60.
Penn, J.S. and L.A. Thum. Oxygen-induced retinopathy in the rat: Role of vitamin E in defending against peroxidation. Ann. N.Y. Acad. Sci. 1989; 495-7.
Penn, J.S., L.A. Thum and M.I. Naash. Photoreceptor physiology in the rat is governed by the light environment. Exp. Eye Res. 1989; 49((2)): 205-15.
Larrazabal, L.I. and J.S. Penn. Study of ocular vasculature in the newborn rat by fluorescein angiography. J. Ophthal. Phot. 1989; 11((2)): 49-52.
Penn, J.S., L.A. Thum, M. Rhem, and S.J. Dell. Effects of oxygen-rearing on the electroretinogram and GFA-protein in the rat. Invest. Ophthalmol. Vis. Sci. 1988; 29((11)): 1623-30.