David R. Head, M.D.

Professor

david.head@vanderbilt.edu
Faculty Appointments
Professor of Pathology, Microbiology and Immunology
Education
M.D., University of Texas, Dallas, TexasB.A., Rice University, Houston, Texas
Office Address
4800B TVC
TN 5310
Research Description
Half of clinical acute myeloid leukemia (AML) is preceded by or similar to Myelodysplastic Syndrome (MDS)(also known as preleukemia). This set of diseases is refractory to current treatment except stem cell transplantation (SCT). Because of its age distribution (elderly), most patients are ineligible for SCT. The pathogenesis of these diseases is unknown, but some data suggest a relationship to interstrand crosslink (ICL) DNA damage. The repair system for correcting such damage is largely unknown. We are evaluating genes upregulated in response to ICL damage as genes possiblly relevant to the pathogenesis of MDS and AML.
Research Keywords
Pathogenesis of Myelodysplastic Syndrome and Acute Myeloid Leukemia
Clinical Research Keywords
Pathogenesis and classification of Acute Myeloid Leukemia and Myelodysplastic Syndrome
Publications
McClintock-Treep SA, Briggs RC, Shults KE, Flye-Blakemore LA, Mosse CA, Jagasia MH, Shinar AA, Dupont WD, Stelzer GT, Head DR. Quantitative assessment of myeloid nuclear differentiation antigen distinguishes myelodysplastic syndrome from normal bone marrow. Am. J. Clin. Pathol. 2011 Mar; 135(3): 380-5. PMID: 21350091, PII: 135/3/380, DOI: 10.1309/AJCP00SHTQCVUYRI, ISSN: 1943-7722.

Head DR, Jacobberger JW, Mosse C, Jagasia M, Dupont W, Goodman S, Flye L, Shinar A, McClintock-Treep S, Stelzer G, Briggs R, Shults K. Innovative analyses support a role for DNA damage and an aberrant cell cycle in myelodysplastic syndrome pathogenesis. Bone Marrow Res [print-electronic]. 2011; 2011: 950934. PMID: 22046573, PMCID: PMC3200066, DOI: 10.1155/2011/950934, ISSN: 2090-3006.

Greenberg PL, Attar E, Bennett JM, Bloomfield CD, De Castro CM, Deeg HJ, Foran JM, Gaensler K, Garcia-Manero G, Gore SD, Head D, Komrokji R, Maness LJ, Millenson M, Nimer SD, O'Donnell MR, Schroeder MA, Shami PJ, Stone RM, Thompson JE, Westervelt P, . NCCN Clinical Practice Guidelines in Oncology: myelodysplastic syndromes. J Natl Compr Canc Netw. 2011 Jan; 9(1): 30-56. PMID: 21233243, PMCID: PMC3768131, PII: 9/1/30.

Qualtieri J, Stratton CW, Head DR, Tang YW. PCR detection of Histoplasma capsulatum var. capsulatum in whole blood of a renal transplant patient with disseminated histoplasmosis. Ann. Clin. Lab. Sci. 2009; 39(4): 409-12. PMID: 19880771, PII: 39/4/409, ISSN: 1550-8080.

Petersdorf SH, Rankin C, Head DR, Terebelo HR, Willman CL, Balcerzak SP, Karnad AB, Dakhil SR, Appelbaum FR. Phase II evaluation of an intensified induction therapy with standard daunomycin and cytarabine followed by high dose cytarabine for adults with previously untreated acute myeloid leukemia: a Southwest Oncology Group study (SWOG-9500). Am. J. Hematol. 2007 Dec; 82(12): 1056-62. PMID: 17696203, DOI: 10.1002/ajh.20994, ISSN: 0361-8609.

Briggs RC, Shults KE, Flye LA, McClintock-Treep SA, Jagasia MH, Goodman SA, Boulos FI, Jacobberger JW, Stelzer GT, Head DR. Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis. Cancer Res. 2006 May 5/1/2006; 66(9): 4645-51. PMID: 16651415, PII: 66/9/4645, DOI: 10.1158/0008-5472.CAN-06-0229, ISSN: 0008-5472.

Appelbaum FR, Gundacker H, Head DR, Slovak ML, Willman CL, Godwin JE, Anderson JE, Petersdorf SH. Age and acute myeloid leukemia. Blood [print-electronic]. 2006 May 5/1/2006; 107(9): 3481-5. PMID: 16455952, PMCID: PMC1895766, PII: 2005-09-3724, DOI: 10.1182/blood-2005-09-3724, ISSN: 0006-4971.

Becton D, Dahl GV, Ravindranath Y, Chang MN, Behm FG, Raimondi SC, Head DR, Stine KC, Lacayo NJ, Sikic BI, Arceci RJ, Weinstein H, . Randomized use of cyclosporin A (CsA) to modulate P-glycoprotein in children with AML in remission: Pediatric Oncology Group Study 9421. Blood [print-electronic]. 2006 Feb 2/15/2006; 107(4): 1315-24. PMID: 16254147, PMCID: PMC1895393, PII: 2004-08-3218, DOI: 10.1182/blood-2004-08-3218, ISSN: 0006-4971.

Hussein MA, Gundacker H, Head DR, Elias L, Foon KA, Boldt DH, Dobin SM, Dakhil SR, Budd GT, Appelbaum FR. Cyclophosphamide followed by fludarabine for untreated chronic lymphocytic leukemia: a phase II SWOG TRIAL 9706. Leukemia. 2005 Nov; 19(11): 1880-6. PMID: 16193091, PII: 2403940, DOI: 10.1038/sj.leu.2403940, ISSN: 0887-6924.

Jiang F, Shults K, Flye L, Hashimoto Y, Van Der Meer R, Xie J, Kravtsov V, Price J, Head DR, Briggs RC. S100P is selectively upregulated in tumor cell lines challenged with DNA cross-linking agents. Leuk. Res. 2005 Oct; 29(10): 1181-90. PMID: 15936073, PII: S0145-2126(05)00148-7, DOI: 10.1016/j.leukres.2005.03.012, ISSN: 0145-2126.

Xie J, Shults K, Flye L, Jiang F, Head DR, Briggs RC. Overexpression of GSTA2 protects against cell cycle arrest and apoptosis induced by the DNA inter-strand crosslinking nitrogen mustard, mechlorethamine. J. Cell. Biochem. 2005 May 5/15/2005; 95(2): 339-51. PMID: 15778998, DOI: 10.1002/jcb.20440, ISSN: 0730-2312.

Shankar S, Choi JK, Dermody TS, Head DR, Bunin N, Iannone R. Pulmonary hypertension complicating bone marrow transplantation for idiopathic myelofibrosis. J. Pediatr. Hematol. Oncol. 2004 Jun; 26(6): 393-7. PMID: 15167356, PII: 00043426-200406000-00013, ISSN: 1077-4114.

Cheson BD, Bennett JM, Kopecky KJ, Büchner T, Willman CL, Estey EH, Schiffer CA, Doehner H, Tallman MS, Lister TA, Lo-Coco F, Willemze R, Biondi A, Hiddemann W, Larson RA, Löwenberg B, Sanz MA, Head DR, Ohno R, Bloomfield CD, . Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J. Clin. Oncol. 2003 Dec 12/15/2003; 21(24): 4642-9. PMID: 14673054, PII: JCO.2003.04.036, DOI: 10.1200/JCO.2003.04.036.

Hasle H, Niemeyer CM, Chessells JM, Baumann I, Bennett JM, Kerndrup G, Head DR. A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases. Leukemia. 2003 Feb; 17(2): 277-82. PMID: 12592323, PII: 2402765, DOI: 10.1038/sj.leu.2402765, ISSN: 0887-6924.

Anderson JE, Kopecky KJ, Willman CL, Head D, O'Donnell MR, Luthardt FW, Norwood TH, Chen IM, Balcerzak SP, Johnson DB, Appelbaum FR. Outcome after induction chemotherapy for older patients with acute myeloid leukemia is not improved with mitoxantrone and etoposide compared to cytarabine and daunorubicin: a Southwest Oncology Group study. Blood [print-electronic]. 2002 Dec 12/1/2002; 100(12): 3869-76. PMID: 12393614, PII: 2001-12-0354, DOI: 10.1182/blood-2001-12-0354, ISSN: 0006-4971.

List AF, Kopecky KJ, Willman CL, Head DR, Slovak ML, Douer D, Dakhil SR, Appelbaum FR. Cyclosporine inhibition of P-glycoprotein in chronic myeloid leukemia blast phase. Blood. 2002 Sep 9/1/2002; 100(5): 1910-2. PMID: 12176916, ISSN: 0006-4971.

Sandlund JT, Harrison PL, Rivera G, Behm FG, Head D, Boyett J, Rubnitz JE, Gajjar A, Raimondi S, Ribeiro R, Hudson M, Relling M, Evans W, Pui CH. Persistence of lymphoblasts in bone marrow on day 15 and days 22 to 25 of remission induction predicts a dismal treatment outcome in children with acute lymphoblastic leukemia. Blood. 2002 Jul 7/1/2002; 100(1): 43-7. PMID: 12070006, ISSN: 0006-4971.

Hinds PS, Quargnenti A, Gattuso J, Kumar Srivastova D, Tong X, Penn L, West N, Cathey P, Hawkins D, Wilimas J, Starr M, Head D. Comparing the results of coagulation tests on blood drawn by venipuncture and through heparinized tunneled venous access devices in pediatric patients with cancer. Oncol Nurs Forum. 2002 Apr; 29(3): E26-34. PMID: 11979291, DOI: 10.1188/02.ONF.E26-E34, ISSN: 1538-0688.

Bloomfield CD, Archer KJ, Mrózek K, Lillington DM, Kaneko Y, Head DR, Dal Cin P, Raimondi SC. 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop. Genes Chromosomes Cancer. 2002 Apr; 33(4): 362-78. PMID: 11921271, PII: 10.1002/gcc.10046, ISSN: 1045-2257.

Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC. Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression. J. Cell. Biochem. 2002; 86(1): 56-66. PMID: 12112016, DOI: 10.1002/jcb.10190, ISSN: 0730-2312.

Head DR. Proposed changes in the definitions of acute myeloid leukemia and myelodysplastic syndrome: are they helpful?. Curr Opin Oncol. 2002 Jan; 14(1): 19-23. PMID: 11790975, ISSN: 1040-8746.

List AF, Kopecky KJ, Willman CL, Head DR, Persons DL, Slovak ML, Dorr R, Karanes C, Hynes HE, Doroshow JH, Shurafa M, Appelbaum FR. Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood. 2001 Dec 12/1/2001; 98(12): 3212-20. PMID: 11719356, ISSN: 0006-4971.

Athale UH, Razzouk BI, Raimondi SC, Tong X, Behm FG, Head DR, Srivastava DK, Rubnitz JE, Bowman L, Pui CH, Ribeiro RC. Biology and outcome of childhood acute megakaryoblastic leukemia: a single institution's experience. Blood. 2001 Jun 6/15/2001; 97(12): 3727-32. PMID: 11389009, ISSN: 0006-4971.

McNall RY, Head DR, Pui CH, Razzouk BI. Parvovirus B19 infection in a child with acute lymphoblastic leukemia during induction therapy. J. Pediatr. Hematol. Oncol. 2001 Jun; 23(5): 309-11. PMID: 11464989, ISSN: 1077-4114.

Krance RA, Hurwitz CA, Head DR, Raimondi SC, Behm FG, Crews KR, Srivastava DK, Mahmoud H, Roberts WM, Tong X, Blakley RL, Ribeiro RC. Experience with 2-chlorodeoxyadenosine in previously untreated children with newly diagnosed acute myeloid leukemia and myelodysplastic diseases. J. Clin. Oncol. 2001 Jun 6/1/2001; 19(11): 2804-11. PMID: 11387351, ISSN: 0732-183X.

Petersdorf SH, Kopecky KJ, Head DR, Boldt DH, Balcerzak SP, Wun T, Roy V, Veith RW, Appelbaum FR. Comparison of the L10M consolidation regimen to an alternative regimen including escalating methotrexate/L-asparaginase for adult acute lymphoblastic leukemia: a Southwest Oncology Group Study. Leukemia. 2001 Feb; 15(2): 208-16. PMID: 11236936, ISSN: 0887-6924.

Slovak ML, Kopecky KJ, Cassileth PA, Harrington DH, Theil KS, Mohamed A, Paietta E, Willman CL, Head DR, Rowe JM, Forman SJ, Appelbaum FR. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood. 2000 Dec 12/15/2000; 96(13): 4075-83. PMID: 11110676, ISSN: 0006-4971.

Flinn IW, Kopecky KJ, Foucar MK, Head D, Bennett JM, Hutchison R, Corbett W, Cassileth P, Habermann T, Golomb H, Rai K, Eisenhauer E, Appelbaum F, Cheson B, Grever MR. Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin. Blood. 2000 Nov 11/1/2000; 96(9): 2981-6. PMID: 11049974, ISSN: 0006-4971.

Rodriguez-Galindo C, Poquette CA, Marina NM, Head DR, Cain A, Meyer WH, Santana VM, Pappo AS. Hematologic abnormalities and acute myeloid leukemia in children and adolescents administered intensified chemotherapy for the Ewing sarcoma family of tumors. J. Pediatr. Hematol. Oncol. 2000 Jul; 22(4): 321-9. PMID: 10959902, ISSN: 1077-4114.

Chauncey TR, Rankin C, Anderson JE, Chen I, Kopecky KJ, Godwin JE, Kalaycio ME, Moore DF, Shurafa MS, Petersdorf SH, Kraut EH, Leith CP, Head DR, Luthardt FW, Willman CL, Appelbaum FR. A phase I study of induction chemotherapy for older patients with newly diagnosed acute myeloid leukemia (AML) using mitoxantrone, etoposide, and the MDR modulator PSC 833: a southwest oncology group study 9617. Leuk. Res. 2000 Jul; 24(7): 567-74. PMID: 10867130, PII: S0145212600000242, ISSN: 0145-2126.

Mathew S, Head D, Rubnitz JE, Raimondi SC. Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2000 Jun; 28(2): 227-32. PMID: 10825008, PII: 10.1002/(SICI)1098-2264(200006)28:2<227::AID-GCC12>3.0.CO;2-J, ISSN: 1045-2257.

Altura RA, Head DR, Wang WC. Long-term survival of infants with idiopathic myelofibrosis. Br. J. Haematol. 2000 May; 109(2): 459-62. PMID: 10848842, PII: bjh1977, ISSN: 0007-1048.

Rosen PJ, Rankin C, Head DR, Boldt DH, Luthardt FW, Norwood T, Pugh RP, Karanes C, Appelbaum FR. A phase II study of high dose ARA-C and mitoxantrone for treatment of relapsed or refractory adult acute lymphoblastic leukemia. Leuk. Res. 2000 Mar; 24(3): 183-7. PMID: 10738999, PII: S0145-2126(99)00148-4, ISSN: 0145-2126.

Mathew S, Head D, Rodriguez-Galindo C, Raimondi SC. Trisomy of the long arm of chromosome 1 resulting in a dicentric derivative (6)t(1;6) chromosome in a child with myelodysplastic syndrome following treatment for a primitive neuroectodermal tumor. Leuk. Lymphoma. 2000 Mar; 37(1-2): 213-8. PMID: 10721789, DOI: 10.3109/10428190009057648, ISSN: 1042-8194.

Chan GC, Head DR, Wang WC. Refractory anemia with ringed sideroblasts in children: two diseases with a similar phenotype?. J. Pediatr. Hematol. Oncol. 1999 Sep; 21(5): 418-23. PMID: 10524457, ISSN: 1077-4114.

Karanes C, Kopecky KJ, Head DR, Grever MR, Hynes HE, Kraut EH, Vial RH, Lichtin A, Nand S, Samlowski WE, Appelbaum FR. A phase III comparison of high dose ARA-C (HIDAC) versus HIDAC plus mitoxantrone in the treatment of first relapsed or refractory acute myeloid leukemia Southwest Oncology Group Study. Leuk. Res. 1999 Sep; 23(9): 787-94. PMID: 10475617, PII: S0145-2126(99)00087-9, ISSN: 0145-2126.

Leith CP, Kopecky KJ, Chen IM, Eijdems L, Slovak ML, McConnell TS, Head DR, Weick J, Grever MR, Appelbaum FR, Willman CL. Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein, MRP1, and LRP in acute myeloid leukemia: a Southwest Oncology Group Study. Blood. 1999 Aug 8/1/1999; 94(3): 1086-99. PMID: 10419902, ISSN: 0006-4971.

Leach CT, Frantz C, Head DR, Gao SJ, McClain KL, Cohen M, Campbell AB, Pollock BH, Murphy SB, Jenson HB. Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell lymphoma in a child with AIDS. Am. J. Hematol. 1999 Mar; 60(3): 215-21. PMID: 10072113, PII: 10.1002/(SICI)1096-8652(199903)60:3<215::AID-AJH8>3.0.CO;2-F, ISSN: 0361-8609.

Navid F, Mosijczuk AD, Head DR, Borowitz MJ, Carroll AJ, Brandt JM, Link MP, Rozans MK, Thomas GA, Schwenn MR, Shields DJ, Vietti TJ, Pullen DJ. Acute lymphoblastic leukemia with the (8;14)(q24;q32) translocation and FAB L3 morphology associated with a B-precursor immunophenotype: the Pediatric Oncology Group experience. Leukemia. 1999 Jan; 13(1): 135-41. PMID: 10049049, ISSN: 0887-6924.

Cassileth PA, Harrington DP, Appelbaum FR, Lazarus HM, Rowe JM, Paietta E, Willman C, Hurd DD, Bennett JM, Blume KG, Head DR, Wiernik PH. Chemotherapy compared with autologous or allogeneic bone marrow transplantation in the management of acute myeloid leukemia in first remission. N. Engl. J. Med. 1998 Dec 12/3/1998; 339(23): 1649-56. PMID: 9834301, DOI: 10.1056/NEJM199812033392301, ISSN: 0028-4793.

Pui CH, Rubnitz JE, Hancock ML, Downing JR, Raimondi SC, Rivera GK, Sandlund JT, Ribeiro RC, Head DR, Relling MV, Evans WE, Behm FG. Reappraisal of the clinical and biologic significance of myeloid-associated antigen expression in childhood acute lymphoblastic leukemia. J. Clin. Oncol. 1998 Dec; 16(12): 3768-73. PMID: 9850020, ISSN: 0732-183X.

Atlas M, Head D, Behm F, Schmidt E, Zeleznik-Le NH, Roe BA, Burian D, Domer PH. Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints. Leukemia. 1998 Dec; 12(12): 1895-902. PMID: 9844920, ISSN: 0887-6924.

Mohamed AN, Varterasian ML, Dobin SM, McConnell TS, Wolman SR, Rankin C, Willman CL, Head DR, Slovak ML. Trisomy 6 as a primary karyotypic aberration in hematologic disorders. Cancer Genet. Cytogenet. 1998 Oct 10/15/1998; 106(2): 152-5. PMID: 9797781, PII: S0165460898000570, ISSN: 0165-4608.

Antillón F, Raimondi SC, Fairman J, Liang H, Nagarajan L, Head D, Ribeiro RC. 5q- in a child with refractory anemia with excess blasts: similarities to 5q- syndrome in adults. Cancer Genet. Cytogenet. 1998 Sep; 105(2): 119-22. PMID: 9723027, PII: S0165460898000193, ISSN: 0165-4608.

Pui CH, Mahmoud HH, Rivera GK, Hancock ML, Sandlund JT, Behm FG, Head DR, Relling MV, Ribeiro RC, Rubnitz JE, Kun LE, Evans WE. Early intensification of intrathecal chemotherapy virtually eliminates central nervous system relapse in children with acute lymphoblastic leukemia. Blood. 1998 Jul 7/15/1998; 92(2): 411-5. PMID: 9657739, ISSN: 0006-4971.

Godwin JE, Kopecky KJ, Head DR, Willman CL, Leith CP, Hynes HE, Balcerzak SP, Appelbaum FR. A double-blind placebo-controlled trial of granulocyte colony-stimulating factor in elderly patients with previously untreated acute myeloid leukemia: a Southwest oncology group study (9031). Blood. 1998 May 5/15/1998; 91(10): 3607-15. PMID: 9572995, ISSN: 0006-4971.

Viswanatha DS, Chen I, Liu PP, Slovak ML, Rankin C, Head DR, Willman CL. Characterization and use of an antibody detecting the CBFbeta-SMMHC fusion protein in inv(16)/t(16;16)-associated acute myeloid leukemias. Blood. 1998 Mar 3/15/1998; 91(6): 1882-90. PMID: 9490670, ISSN: 0006-4971.

Kuefer MU, Wang WC, Head DR, Wilimas JA, Furman WL, Liu Q, Hornkohl AC, Best DM, Jackson CW. Thrombopoietin level in young patients is related to megakaryocyte frequency and platelet count. J. Pediatr. Hematol. Oncol. 1998 Jan; 20(1): 36-43. PMID: 9482411, ISSN: 1077-4114.

Leith CP, Kopecky KJ, Godwin J, McConnell T, Slovak ML, Chen IM, Head DR, Appelbaum FR, Willman CL. Acute myeloid leukemia in the elderly: assessment of multidrug resistance (MDR1) and cytogenetics distinguishes biologic subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood. 1997 May 5/1/1997; 89(9): 3323-9. PMID: 9129038, ISSN: 0006-4971.

Rubnitz JE, Downing JR, Pui CH, Shurtleff SA, Raimondi SC, Evans WE, Head DR, Crist WM, Rivera GK, Hancock ML, Boyett JM, Buijs A, Grosveld G, Behm FG. TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance. J. Clin. Oncol. 1997 Mar; 15(3): 1150-7. PMID: 9060558, ISSN: 0732-183X.

Chan GC, Wang WC, Raimondi SC, Behm FG, Krance RA, Chen G, Freiberg A, Ingram L, Butler D, Head DR. Myelodysplastic syndrome in children: differentiation from acute myeloid leukemia with a low blast count. Leukemia. 1997 Feb; 11(2): 206-11. PMID: 9009082, ISSN: 0887-6924.

Tsai T, Davalath S, Rankin C, Radich JP, Head D, Appelbaum FR, Boldt DH. Tumor suppressor gene alteration in adult acute lymphoblastic leukemia (ALL). Analysis of retinoblastoma (Rb) and p53 gene expression in lymphoblasts of patients with de novo, relapsed, or refractory ALL treated in Southwest Oncology Group studies. Leukemia. 1996 Dec; 10(12): 1901-10. PMID: 8946929, ISSN: 0887-6924.

Slobod KS, Bennett TA, Freiden PJ, Kechli AM, Howlett N, Flynn PM, Head DR, Srivastava DK, Boyett JM, Brenner MK, Garcia JV. Mobilization of CD34+ progenitor cells by granulocyte colony-stimulating factor in human immunodeficiency virus type 1-infected adults. Blood. 1996 Nov 11/1/1996; 88(9): 3329-35. PMID: 8896397, ISSN: 0006-4971.

Head DR. Revised classification of acute myeloid leukemia. Leukemia. 1996 Nov; 10(11): 1826-31. PMID: 8892688, ISSN: 0887-6924.

Weick JK, Kopecky KJ, Appelbaum FR, Head DR, Kingsbury LL, Balcerzak SP, Bickers JN, Hynes HE, Welborn JL, Simon SR, Grever M. A randomized investigation of high-dose versus standard-dose cytosine arabinoside with daunorubicin in patients with previously untreated acute myeloid leukemia: a Southwest Oncology Group study. Blood. 1996 Oct 10/15/1996; 88(8): 2841-51. PMID: 8874180, ISSN: 0006-4971.

Kane JR, Head DR, Balazs L, Hulshof MG, Motroni TA, Raimondi SC, Carroll AJ, Behm FG, Krance RA, Shurtleff SA, Downing JR. Molecular analysis of the PML/RAR alpha chimeric gene in pediatric acute promyelocytic leukemia. Leukemia. 1996 Aug; 10(8): 1296-302. PMID: 8709634, ISSN: 0887-6924.

Broniscer A, Ribeiro RC, Srinivas RV, Behm FG, Head DR, Raimondi SC, Mandrell B, Gill P. An adolescent with HTLV-I-associated adult T cell leukemia treated with interferon-alfa and zidovudine. Leukemia. 1996 Jul; 10(7): 1244-8. PMID: 8684010, ISSN: 0887-6924.

Beck WT, Grogan TM, Willman CL, Cordon-Cardo C, Parham DM, Kuttesch JF, Andreeff M, Bates SE, Berard CW, Boyett JM, Brophy NA, Broxterman HJ, Chan HS, Dalton WS, Dietel M, Fojo AT, Gascoyne RD, Head D, Houghton PJ, Srivastava DK, Lehnert M, Leith CP, Paietta E, Pavelic ZP, Weinstein R. Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res. 1996 Jul 7/1/1996; 56(13): 3010-20. PMID: 8674056, ISSN: 0008-5472.

Bowman WP, Shuster JJ, Cook B, Griffin T, Behm F, Pullen J, Link M, Head D, Carroll A, Berard C, Murphy S. Improved survival for children with B-cell acute lymphoblastic leukemia and stage IV small noncleaved-cell lymphoma: a pediatric oncology group study. J. Clin. Oncol. 1996 Apr; 14(4): 1252-61. PMID: 8648381, ISSN: 0732-183X.

Head DR, Behm FG. Acute lymphoblastic leukemia and the lymphoblastic lymphomas of childhood. Semin Diagn Pathol. 1995 Nov; 12(4): 325-34. PMID: 8578027, ISSN: 0740-2570.

Kanwar VS, Wang WC, Winer-Muram HT, Kauffman WM, Gronemeyer SA, Head DR. Magnetic resonance imaging for evaluation of childhood aplastic anemia. J. Pediatr. Hematol. Oncol. 1995 Nov; 17(4): 284-9. PMID: 7583382, ISSN: 1077-4114.

Leith CP, Chen IM, Kopecky KJ, Appelbaum FR, Head DR, Godwin JE, Weick JK, Willman CL. Correlation of multidrug resistance (MDR1) protein expression with functional dye/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR-/efflux+ and MDR1+/efflux- cases. Blood. 1995 Sep 9/15/1995; 86(6): 2329-42. PMID: 7545025, ISSN: 0006-4971.

Raimondi SC, Frestedt JL, Pui CH, Downing JR, Head DR, Kersey JH, Behm FG. Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical features. Blood. 1995 Sep 9/1/1995; 86(5): 1881-6. PMID: 7655016, ISSN: 0006-4971.

Head D, Kopecky KJ, Weick J, Files JC, Ryan D, Foucar K, Montiel M, Bickers J, Fishleder A, Miller M. Effect of aggressive daunomycin therapy on survival in acute promyelocytic leukemia. Blood. 1995 Sep 9/1/1995; 86(5): 1717-28. PMID: 7655004, ISSN: 0006-4971.

Domer PH, Head DR, Renganathan N, Raimondi SC, Yang E, Atlas M. Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11). Leukemia. 1995 Aug; 9(8): 1305-12. PMID: 7643617, ISSN: 0887-6924.

Mehrotra B, George TI, Kavanau K, Avet-Loiseau H, Moore D, Willman CL, Slovak ML, Atwater S, Head DR, Pallavicini MG. Cytogenetically aberrant cells in the stem cell compartment (CD34+lin-) in acute myeloid leukemia. Blood. 1995 Aug 8/1/1995; 86(3): 1139-47. PMID: 7542497, ISSN: 0006-4971.

Shurtleff SA, Meyers S, Hiebert SW, Raimondi SC, Head DR, Willman CL, Wolman S, Slovak ML, Carroll AJ, Behm F. Heterogeneity in CBF beta/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia. Blood. 1995 Jun 6/15/1995; 85(12): 3695-703. PMID: 7780153, ISSN: 0006-4971.

Downing JR, Shurtleff SA, Zielenska M, Curcio-Brint AM, Behm FG, Head DR, Sandlund JT, Weisenburger DD, Kossakowska AE, Thorner P. Molecular detection of the (2;5) translocation of non-Hodgkin's lymphoma by reverse transcriptase-polymerase chain reaction. Blood. 1995 Jun 6/15/1995; 85(12): 3416-22. PMID: 7780128, ISSN: 0006-4971.

Slovak ML, Traweek ST, Willman CL, Head DR, Kopecky KJ, Magenis RE, Appelbaum FR, Forman SJ. Trisomy 11: an association with stem/progenitor cell immunophenotype. Br. J. Haematol. 1995 Jun; 90(2): 266-73. PMID: 7794746, ISSN: 0007-1048.

Filatov LV, Behm FG, Pui CH, Head DR, Downing JR, Raimondi SC. Childhood acute lymphoblastic leukemia with equivocal chromosome markers of the t(1;19) translocation. Genes Chromosomes Cancer. 1995 Jun; 13(2): 99-103. PMID: 7542913, ISSN: 1045-2257.

Okuda T, Shurtleff SA, Valentine MB, Raimondi SC, Head DR, Behm F, Curcio-Brint AM, Liu Q, Pui CH, Sherr CJ. Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia. Blood. 1995 May 5/1/1995; 85(9): 2321-30. PMID: 7727766, ISSN: 0006-4971.

Hewlett J, Kopecky KJ, Head D, Eyre HJ, Elias L, Kingsbury L, Balcerzak SP, Dabich L, Hynes H, Bickers JN. A prospective evaluation of the roles of allogeneic marrow transplantation and low-dose monthly maintenance chemotherapy in the treatment of adult acute myelogenous leukemia (AML): a Southwest Oncology Group study. Leukemia. 1995 Apr; 9(4): 562-9. PMID: 7723385, ISSN: 0887-6924.

Bigelow CL, Kopecky K, Files JC, Head D, Lipschitz DA, Grever M, Appelbaum FR. Treatment of acute myelogenous leukemia in patients over 50 years of age with V-TAD: a Southwest Oncology Group study. Am. J. Hematol. 1995 Apr; 48(4): 228-32. PMID: 7717369, ISSN: 0361-8609.

Grever M, Kopecky K, Foucar MK, Head D, Bennett JM, Hutchison RE, Corbett WE, Cassileth PA, Habermann T, Golomb H. Randomized comparison of pentostatin versus interferon alfa-2a in previously untreated patients with hairy cell leukemia: an intergroup study. J. Clin. Oncol. 1995 Apr; 13(4): 974-82. PMID: 7707126, ISSN: 0732-183X.

Downing JR, Khandekar A, Shurtleff SA, Head DR, Parham DM, Webber BL, Pappo AS, Hulshof MG, Conn WP, Shapiro DN. Multiplex RT-PCR assay for the differential diagnosis of alveolar rhabdomyosarcoma and Ewing's sarcoma. Am. J. Pathol. 1995 Mar; 146(3): 626-34. PMID: 7887445, PMCID: PMC1869175, ISSN: 0002-9440.

Licht JD, Chomienne C, Goy A, Chen A, Scott AA, Head DR, Michaux JL, Wu Y, DeBlasio A, Miller WH. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood. 1995 Feb 2/15/1995; 85(4): 1083-94. PMID: 7849296, ISSN: 0006-4971.

Boldt DH, Kopecky KJ, Head D, Gehly G, Radich JP, Appelbaum FR. Expression of myeloid antigens by blast cells in acute lymphoblastic leukemia of adults. The Southwest Oncology Group experience. Leukemia. 1994 Dec; 8(12): 2118-26. PMID: 7807999, ISSN: 0887-6924.

Radich JP, Kopecky KJ, Boldt DH, Head D, Slovak ML, Babu R, Kirk J, Lee A, Kessler P, Appelbaum F. Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction. Leukemia. 1994 Oct; 8(10): 1688-95. PMID: 7934164, ISSN: 0887-6924.

Gallego M, Carroll AJ, Gad GS, Pappo A, Head D, Behm F, Ravindranath Y, Raimondi SC. Variant t(8;21) rearrangements in acute myeloblastic leukemia of childhood. Cancer Genet. Cytogenet. 1994 Jul 7/15/1994; 75(2): 139-44. PMID: 8055478, PII: 0165-4608(94)90166-X, ISSN: 0165-4608.

Scott AA, Head DR, Kopecky KJ, Appelbaum FR, Theil KS, Grever MR, Chen IM, Whittaker MH, Griffith BB, Licht JD. HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood. 1994 Jul 7/1/1994; 84(1): 244-55. PMID: 7517211, ISSN: 0006-4971.

Pui CH, Behm FG, Downing JR, Hancock ML, Shurtleff SA, Ribeiro RC, Head DR, Mahmoud HH, Sandlund JT, Furman WL. 11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. J. Clin. Oncol. 1994 May; 12(5): 909-15. PMID: 8164041, ISSN: 0732-183X.

Downing JR, Head DR, Raimondi SC, Carroll AJ, Curcio-Brint AM, Motroni TA, Hulshof MG, Pullen DJ, Domer PH. The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia. Blood. 1994 Jan 1/15/1994; 83(2): 330-5. PMID: 8286732, ISSN: 0006-4971.

Sawyer JR, Roloson GJ, Head DR, Becton D. Karyotype evolution in a patient with Down syndrome and acute leukemia following a congenital leukemoid reaction. Med. Pediatr. Oncol. 1994; 22(6): 404-9. PMID: 8152402, ISSN: 0098-1532.

Head DR, Kopecky KJ, Willman C, Appelbaum FR. Treatment outcome with chemotherapy in acute promyelocytic leukemia: the Southwest Oncology Group (SWOG) experience. Leukemia. 1994; 8 Suppl 2: S38-41. PMID: 7815835, ISSN: 0887-6924.

Koehler M, Behm FG, Shuster J, Crist W, Borowitz M, Look AT, Head D, Carroll AJ, Land V, Steuber P. Transitional pre-B-cell acute lymphoblastic leukemia of childhood is associated with favorable prognostic clinical features and an excellent outcome: a Pediatric Oncology Group study. Leukemia. 1993 Dec; 7(12): 2064-8. PMID: 8255107, ISSN: 0887-6924.

Downing JR, Head DR, Parham DM, Douglass EC, Hulshof MG, Link MP, Motroni TA, Grier HE, Curcio-Brint AM, Shapiro DN. Detection of the (11;22)(q24;q12) translocation of Ewing's sarcoma and peripheral neuroectodermal tumor by reverse transcription polymerase chain reaction. Am. J. Pathol. 1993 Nov; 143(5): 1294-300. PMID: 8238248, PMCID: PMC1887175, ISSN: 0002-9440.

Gad SG, Callen DF, Kuss B, Downing JR, Behm F, Head D, Ribeiro RC, Raimondi SC. Identification of an inversion 16 coexisting with an isochromosome 22q by in situ hybridization in a case of childhood AML M4e. Leukemia. 1993 Oct; 7(10): 1658-62. PMID: 8412329, ISSN: 0887-6924.

Pui CH, Hancock ML, Head DR, Rivera GK, Look AT, Sandlund JT, Behm FG. Clinical significance of CD34 expression in childhood acute lymphoblastic leukemia. Blood. 1993 Aug 8/1/1993; 82(3): 889-94. PMID: 7687897, ISSN: 0006-4971.

Raimondi SC, Pui CH, Head DR, Rivera GK, Behm FG. Cytogenetically different leukemic clones at relapse of childhood acute lymphoblastic leukemia. Blood. 1993 Jul 7/15/1993; 82(2): 576-80. PMID: 8329712, ISSN: 0006-4971.

Mirro J, Hurwitz CA, Behm FG, Head DR, Raimondi SC, Crist WM, Ihle JN. Effects of recombinant human hematopoietic growth factors on leukemic blasts from children with acute myeloblastic or lymphoblastic leukemia. Leukemia. 1993 Jul; 7(7): 1026-33. PMID: 8321018, ISSN: 0887-6924.

Ribeiro RC, Oliveira MS, Fairclough D, Hurwitz C, Mirro J, Behm FG, Head D, Silva ML, Raimondi SC, Crist WM. Acute megakaryoblastic leukemia in children and adolescents: a retrospective analysis of 24 cases. Leuk. Lymphoma. 1993 Jul; 10(4-5): 299-306. PMID: 8220128, DOI: 10.3109/10428199309148552, ISSN: 1042-8194.

Downing JR, Head DR, Curcio-Brint AM, Hulshof MG, Motroni TA, Raimondi SC, Carroll AJ, Drabkin HA, Willman C, Theil KS. An AML1/ETO fusion transcript is consistently detected by RNA-based polymerase chain reaction in acute myelogenous leukemia containing the (8;21)(q22;q22) translocation. Blood. 1993 Jun 6/1/1993; 81(11): 2860-5. PMID: 8499624, ISSN: 0006-4971.

Sandoval C, Pui CH, Bowman LC, Heaton D, Hurwitz CA, Raimondi SC, Behm FG, Head DR. Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation. J. Clin. Oncol. 1993 Jun; 11(6): 1039-45. PMID: 8388919, ISSN: 0732-183X.

Cantú-Rajnoldi A, Biondi A, Jankovic M, Masera G, Rovelli A, Uderzo C, Head D, Raimondi S, Creutzig V, Ritter J. Diagnosis and incidence of acute promyelocytic leukemia (FAB M3 and M3 variant) in childhood [letter]. Blood. 1993 Apr 4/15/1993; 81(8): 2209-10. PMID: 8471781, ISSN: 0006-4971.

Elias L, Stock-Novack D, Head DR, Grever MR, Weick JK, Chapman RA, Godwin JE, Metz EN, Appelbaum FR. A phase I trial of combination fludarabine monophosphate and chlorambucil in chronic lymphocytic leukemia: a Southwest Oncology Group study. Leukemia. 1993 Mar; 7(3): 361-5. PMID: 7680398, ISSN: 0887-6924.

Hurwitz CA, Raimondi SC, Head D, Krance R, Mirro J, Kalwinsky DK, Ayers GD, Behm FG. Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children. Blood. 1992 Dec 12/15/1992; 80(12): 3182-8. PMID: 1467524, ISSN: 0006-4971.

Miller KB, Kim K, Morrison FS, Winter JN, Bennett JM, Neiman RS, Head DR, Cassileth PA, O'Connell MJ. The evaluation of low-dose cytarabine in the treatment of myelodysplastic syndromes: a phase-III intergroup study. Ann. Hematol. 1992 Oct; 65(4): 162-8. PMID: 1420504, ISSN: 0939-5555.

Chan WC, Carroll A, Alvarado CS, Phillips S, Gonzalez-Crussi F, Kurczynski E, Pappo A, Emami A, Bowman P, Head DR. Acute megakaryoblastic leukemia in infants with t(1;22)(p13;q13) abnormality. Am. J. Clin. Pathol. 1992 Aug; 98(2): 214-21. PMID: 1510033, ISSN: 0002-9173.

Morrison FS, Kopecky KJ, Head DR, Athens JW, Balcerzak SP, Gumbart C, Dabich L, Costanzi JJ, Coltman CA, Saiki JH. Late intensification with POMP chemotherapy prolongs survival in acute myelogenous leukemia--results of a Southwest Oncology Group study of rubidazone versus adriamycin for remission induction, prophylactic intrathecal therapy, late intensification, and levamisole maintenance. Leukemia. 1992 Jul; 6(7): 708-14. PMID: 1625490, ISSN: 0887-6924.

Sandoval C, Head DR, Mirro J, Behm FG, Ayers GD, Raimondi SC. Translocation t(9;11)(p21;q23) in pediatric de novo and secondary acute myeloblastic leukemia. Leukemia. 1992 Jun; 6(6): 513-9. PMID: 1602790, ISSN: 0887-6924.

Pui CH, Carroll AJ, Raimondi SC, Schell MJ, Head DR, Shuster JJ, Crist WM, Borowitz MJ, Link MP, Behm FG. Isochromosomes in childhood acute lymphoblastic leukemia: a collaborative study of 83 cases. Blood. 1992 May 5/1/1992; 79(9): 2384-91. PMID: 1571550, ISSN: 0006-4971.

Abshire TC, Buchanan GR, Jackson JF, Shuster JJ, Brock B, Head D, Behm F, Crist WM, Link M, Borowitz M. Morphologic, immunologic and cytogenetic studies in children with acute lymphoblastic leukemia at diagnosis and relapse: a Pediatric Oncology Group study. Leukemia. 1992 May; 6(5): 357-62. PMID: 1534389, ISSN: 0887-6924.

Betz SA, Foucar K, Head DR, Chen IM, Willman CL. False-positive flow cytometric platelet glycoprotein IIb/IIIa expression in myeloid leukemias secondary to platelet adherence to blasts. Blood. 1992 May 5/1/1992; 79(9): 2399-403. PMID: 1349244, ISSN: 0006-4971.

Raimondi SC, Pui CH, Head D, Behm F, Privitera E, Roberson PK, Rivera GK, Williams DL. Trisomy 21 as the sole acquired chromosomal abnormality in children with acute lymphoblastic leukemia. Leukemia. 1992 Mar; 6(3): 171-5. PMID: 1533007, ISSN: 0887-6924.

Head DR, Downing JR. Pathology and immunology of leukemia. Curr Opin Oncol. 1992 Feb; 4(1): 14-23. PMID: 1591285, ISSN: 1040-8746.

Ryan DH, Kopecky KJ, Head D, Grever MR, Shiaer SM, Lipschitz DA, Hynes HE, Vial RH, Veith RW, Gumbart CH. Analysis of treatment failure in acute nonlymphocytic leukemia patients over fifty years of age. A Southwest Oncology Group study. Am. J. Clin. Oncol. 1992 Feb; 15(1): 69-75. PMID: 1550082, ISSN: 0277-3732.

Pui CH, Ribeiro RC, Hancock ML, Rivera GK, Evans WE, Raimondi SC, Head DR, Behm FG, Mahmoud MH, Sandlund JT. Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia. N. Engl. J. Med. 1991 Dec 12/12/1991; 325(24): 1682-7. PMID: 1944468, DOI: 10.1056/NEJM199112123252402, ISSN: 0028-4793.

Eguiguren JM, Ribeiro RC, Pui CH, Hancock ML, Pratt CB, Head DR, Crist WM. Secondary non-Hodgkin's lymphoma after treatment for childhood cancer. Leukemia. 1991 Oct; 5(10): 908-11. PMID: 1961025, ISSN: 0887-6924.

Pui CH, Raimondi SC, Head DR, Schell MJ, Rivera GK, Mirro J, Crist WM, Behm FG. Characterization of childhood acute leukemia with multiple myeloid and lymphoid markers at diagnosis and at relapse. Blood. 1991 Sep 9/1/1991; 78(5): 1327-37. PMID: 1878594, ISSN: 0006-4971.

Carter M, Kalwinsky DK, Mirro J, Behm FG, Head D, Huddleston TF, Raimondi SC. The t(10;11)(p14;q21) translocation in three children with acute myeloblastic leukemia. Leukemia. 1991 Jul; 5(7): 561-5. PMID: 2072741, ISSN: 0887-6924.

Saikevych IA, Kerrigan DP, McConnell TS, Head DR, Appelbaum FR, Willman CL. Multiparameter analysis of acute mixed lineage leukemia: correlation of a B/myeloid immunophenotype and immunoglobulin and T-cell receptor gene rearrangements with the presence of the Philadelphia chromosome translocation in acute leukemias with myeloid morphology. Leukemia. 1991 May; 5(5): 373-82. PMID: 2033959, ISSN: 0887-6924.

Cerezo L, Shuster JJ, Pullen DJ, Brock B, Borowitz MJ, Falletta JM, Crist WM, Head DR. Laboratory correlates and prognostic significance of granular acute lymphoblastic leukemia in children. A Pediatric Oncology Group study. Am. J. Clin. Pathol. 1991 Apr; 95(4): 526-31. PMID: 1805807, ISSN: 0002-9173.

Willman CL, Stewart CC, Longacre TL, Head DR, Habbersett R, Ziegler SF, Perlmutter RM. Expression of the c-fgr and hck protein-tyrosine kinases in acute myeloid leukemic blasts is associated with early commitment and differentiation events in the monocytic and granulocytic lineages. Blood. 1991 Feb 2/15/1991; 77(4): 726-34. PMID: 1825181, ISSN: 0006-4971.

Pui CH, Frankel LS, Carroll AJ, Raimondi SC, Shuster JJ, Head DR, Crist WM, Land VJ, Pullen DJ, Steuber CP. Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia with the t(4;11)(q21;q23): a collaborative study of 40 cases. Blood. 1991 Feb 2/1/1991; 77(3): 440-7. PMID: 1991161, ISSN: 0006-4971.

Jackson JF, Boyett J, Pullen J, Brock B, Patterson R, Land V, Borowitz M, Head D, Crist W. Favorable prognosis associated with hyperdiploidy in children with acute lymphocytic leukemia correlates with extra chromosome 6. A Pediatric Oncology Group study. Cancer. 1990 Sep 9/15/1990; 66(6): 1183-9. PMID: 2205354, ISSN: 0008-543X.

Pui CH, Hancock ML, Raimondi SC, Head DR, Thompson E, Wilimas J, Kun LE, Bowman LC, Crist WM, Pratt CB. Myeloid neoplasia in children treated for solid tumours. Lancet. 1990 Aug 8/18/1990; 336(8712): 417-21. PMID: 1974952, PII: 0140-6736(90)91956-B, ISSN: 0140-6736.

Radich JP, Kopecky KJ, Willman CL, Weick J, Head D, Appelbaum F, Collins SJ. N-ras mutations in adult de novo acute myelogenous leukemia: prevalence and clinical significance. Blood. 1990 Aug 8/15/1990; 76(4): 801-7. PMID: 2200539, ISSN: 0006-4971.

Pui CH, Carroll AJ, Head D, Raimondi SC, Shuster JJ, Crist WM, Link MP, Borowitz MJ, Behm FG, Land VJ. Near-triploid and near-tetraploid acute lymphoblastic leukemia of childhood. Blood. 1990 Aug 8/1/1990; 76(3): 590-6. PMID: 2378987, ISSN: 0006-4971.

Crist W, Carroll A, Shuster J, Jackson J, Head D, Borowitz M, Behm F, Link M, Steuber P, Ragab A. Philadelphia chromosome positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome. A Pediatric Oncology Group study. Blood. 1990 Aug 8/1/1990; 76(3): 489-94. PMID: 2378982, ISSN: 0006-4971.

Cheson BD, Cassileth PA, Head DR, Schiffer CA, Bennett JM, Bloomfield CD, Brunning R, Gale RP, Grever MR, Keating MJ. Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia. J. Clin. Oncol. 1990 May; 8(5): 813-9. PMID: 2185339, ISSN: 0732-183X.

Sullivan MP, Pullen DJ, Crist WM, Brecher M, Ramirez I, Sabio H, Borowitz MJ, Head DR, Cerezo L, Shuster JJ. Clinical and biological heterogeneity of childhood B cell acute lymphocytic leukemia: implications for clinical trials. Leukemia. 1990 Jan; 4(1): 6-11. PMID: 2404163, ISSN: 0887-6924.

Head DR, Kopecky K, Bennett JM, Grenier K, Morrison FS, Miller KB, Grever MR. Pathogenetic implications of internuclear bridging in myelodysplastic syndrome. An Eastern Cooperative Oncology Group/Southwest Oncology Group Cooperative Study. Cancer. 1989 Dec 12/1/1989; 64(11): 2199-202. PMID: 2804910, ISSN: 0008-543X.

Crist W, Boyett J, Jackson J, Vietti T, Borowitz M, Chauvenet A, Winick N, Ragab A, Mahoney D, Head D. Prognostic importance of the pre-B-cell immunophenotype and other presenting features in B-lineage childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood. 1989 Sep; 74(4): 1252-9. PMID: 2669998, ISSN: 0006-4971.

Hussein KK, Dahlberg S, Head D, Waddell CC, Dabich L, Weick JK, Morrison F, Saiki JH, Metz E, Rivkin SE. Treatment of acute lymphoblastic leukemia in adults with intensive induction, consolidation, and maintenance chemotherapy. Blood. 1989 Jan; 73(1): 57-63. PMID: 2642717, ISSN: 0006-4971.

Head DR, Avakian J, Kjeldsberg CR, Cerezo L. Relapse of intermediate or high-grade (unfavorable) non-Hodgkin's lymphoma as a low-grade (favorable) Non-Hodgkin's lymphoma. Report of four cases. Am. J. Clin. Pathol. 1988 Jan; 89(1): 106-8. PMID: 3337045, ISSN: 0002-9173.

Cerezo L, Head DR. Immunologic phenotype of acute lymphoblastic leukemias [letter]. Hum. Pathol. 1987 Oct; 18(10): 1078. PMID: 3477521, ISSN: 0046-8177.

Ryan DH, Kopecky KJ, Head D, Gumbart CN, Grever MR, Karanes C, Weick JK, Coltman CA. Phase II evaluation of teniposide and ifosfamide in refractory adult acute lymphocytic leukemia: a Southwest Oncology Group Study. Cancer Treat Rep. 1987 Jul; 71(7-8): 713-6. PMID: 3475171, ISSN: 0361-5960.

Head DR, Kjeldsberg CR, Kadin ME, Pick T, Bybee B, Longbotham J, Shumski E. Childhood T-cell malignancy resembling adult T-cell leukemia/lymphoma. Hematol Pathol. 1987; 1(1): 15-25. PMID: 3504428, ISSN: 0886-0238.

Frame R, Head D, Lee R, Craven C, Ward JH. Granulocytic sarcoma of the prostate. Two cases causing urinary obstruction. Cancer. 1987 Jan 1/1/1987; 59(1): 142-6. PMID: 2431755, ISSN: 0008-543X.

Head DR, Hughes K, Marty J. The bone marrow biopsy: a diagnostic strategy [letter]. Arch. Pathol. Lab. Med. 1986 Dec; 110(12): 1120-1. PMID: 3778136, ISSN: 0003-9985.

Head DR, Borowitz M, Cerezo L, Craven CM, Brock BL, Boyett JM, Pullen DJ, Crist WM, Falletta J, Humphrey GB. Acid phosphatase positivity in childhood acute lymphocytic leukemia. Am. J. Clin. Pathol. 1986 Nov; 86(5): 650-3. PMID: 3465229, ISSN: 0002-9173.

Beck LS, Strickland RD, Bagley BL, Mortensen JD, Hammond ME, Ashton AH, Head DR, Braun MR, Weiler MJ. Large-animal model of chronic congestive heart failure induced by intracoronary allylamine. ASAIO Trans. 1986 Jul; 32(1): 238-41. PMID: 3778717, ISSN: 0889-7190.

van Eys J, Pullen J, Head D, Boyett J, Crist W, Falletta J, Humphrey GB, Jackson J, Riccardi V, Brock B. The French-American-British (FAB) classification of leukemia. The Pediatric Oncology Group experience with lymphocytic leukemia. Cancer. 1986 Mar 3/1/1986; 57(5): 1046-51. PMID: 3484662, ISSN: 0008-543X.

Head DR. Whole blood versus packed red cells [letter]. Transfusion. 1985 Nov; 25(6): 591. PMID: 4071608, ISSN: 0041-1132.

Spier CM, Kjeldsberg CR, Head DR, DiFiore KC, Tudor B. Chronic lymphocytic leukemia in young adults. Am. J. Clin. Pathol. 1985 Nov; 84(5): 675-8. PMID: 3877453, ISSN: 0002-9173.

Head DR, Cerezo L, Savage RA, Craven CM, Bickers JN, Hartsock R, Hosty TA, Saiki JH, Wilson HE, Morrison FS. Institutional performance in application of the FAB classification of acute leukemia. The Southwest Oncology Group experience. Cancer. 1985 May 5/1/1985; 55(9): 1979-86. PMID: 3856465, ISSN: 0008-543X.

Head DR, Savage RA, Cerezo L, Craven CM, Bickers JN, Hartsock R, Hosty TA, Saiki JH, Wilson HE, Morrison FS. Reproducibility of the French-American-British classification of acute leukemia: the Southwest Oncology Group Experience. Am. J. Hematol. 1985 Jan; 18(1): 47-57. PMID: 2981467, ISSN: 0361-8609.

Cerezo L, Head DR, Pullen J, Humphrey B. The prevalence of hand-mirror cells in acute myeloblastic and lymphoblastic leukemia. Am. J. Clin. Pathol. 1984 Mar; 81(3): 355-7. PMID: 6584027, ISSN: 0002-9173.

Herrera GA, Head DR. Histiocytic lymphoma arising at the site of injection of anti-lymphocytic globulin: necropsy follow-up of previously reported case. Mil Med. 1981 Sep; 146(9): 652-4. PMID: 6793917, ISSN: 0026-4075.

McCue MJ, Brossoit AD, Marmer DJ, Head DR. Von Willebrand Factor (VIIIVWF) in lyophilized Factor VIII concentrates. Am. J. Hematol. 1980; 9(1): 39-42. PMID: 6776806, ISSN: 0361-8609.

Head DR, Bowman RP, Marmer DJ, Brossoit AD. An improvemed assay for von Willebrand factor. Am. J. Clin. Pathol. 1979 Dec; 72(6): 991-5. PMID: 117698, ISSN: 0002-9173.

Head DR, Kennedy PS, Goyette RE. Metastatic neuroblastoma in bone marrow aspirate smears. Am. J. Clin. Pathol. 1979 Dec; 72(6): 1008-11. PMID: 92888, ISSN: 0002-9173.

Karcher DS, Head DR, Mullins JD. Malignant histiocytosis occurring in patients with acute lymphocytic leukemia. Cancer. 1978 May; 41(5): 1967-73. PMID: 274172, ISSN: 0008-543X.

Haburchak DR, Head DR, Everett ED. Postoperative hemorrhage associated with carbenicillin administration. Report of two cases and review of the literature. Am. J. Surg. 1977 Nov; 134(5): 630-4. PMID: 920895, PII: 0002-9610(77)90451-2, ISSN: 0002-9610.

Head DR, Bowman RP, Marmer DJ, Brossoit AD. Von Willebrand's disease [letter]. N. Engl. J. Med. 1977 Sep 9/8/1977; 297(10): 558. PMID: 301985, ISSN: 0028-4793.

Zuck TF, Head DR. Blood-transfusion in the presence of haemolytic anaemia. Lancet. 1971 Aug 8/14/1971; 2(7720): 382-3. PMID: 4105085, PII: S0140-6736(71)90103-6, ISSN: 0140-6736.