Billy G. Hudson, Ph.D.


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Faculty Appointments
Professor of Medicine Professor of BiochemistryProfessor of Cell and Developmental BiologyElliott V. Newman Professor of MedicineProfessor of Pathology, Microbiology and Immunology
Ph.D., Biochemistry, University of Iowa, Iowa City, IowaM.S., University of Tennessee, Knoxville, TennesseeB.S., Henderson State University, Arkadelphia, Arkansas
Office Address
B-3102 Medical Center North
1161 Twenty-first Avenue South
Nashville, TN 37232-2372
Research Description
My research program focuses on the structure and function of type IV collagen, the major constitutent of basement membranes (BMs). BMs are a specialized form of extracellular matrix that compartmentalizes tissues and play an important role in tissue remodeling and morphogenesis. BM function is impaired in both hereditary and acquired diseases that affect type IV collagen. In Alport syndrome, a hereditary renal disease, the collagen genes are mutated. In Goodpasture syndrome, a rapidly progressive renal disease with lung hemorrhage, the collagen is the target for autoantibodies. In diabetes, the vascular complications of nephropathy and retinopathy also appear to involve this collagen.
Type IV collagen has recently emerged as a family of six homologous alpha-chains, designated alpha1 to alpha6. My research group discovered the alpha3 and alpha4 chains. The alpha3 chain is the target for autoantibodies in Goodpasture syndrome and the alpha5 chain is the target for autoantibodies in a novel autoimmune disease that causes renal disease and skin blistering. The alpha3, alpha4, and alpha5 chains are mutated in Alport syndrome causing defective assembly of a supramolecular network which leads to progressive renal failure. Recently we have shown that the code for the assembly of chain-specific networks resides within the noncollagenous (NC1) domain of the collagen chains. The three-dimensional structure of this domain was recently determined by x-ray crystallography, revealing novel information about structure and function.
Most recently, we discovered that type IV collagen may represent an important new class of anti-angiogenic molecules for the treatment of neovascular diseases, such as tumor growth and metastasis. Our findings have led to the development of two drugs: Pyridorin, a molecule inhibitor for the treatment of diabetic renal disease now in phase II trials, and Angiocol an anti-angiogenesis agent that targets basal lamina, slated for a phase I trial next year.
Research Keywords
The structure and function of type IV collagen, the major constituent of basement membranes (BMs).
Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming. Matrix Biol [print-electronic]. 2017 Jan; 57-58: 347-65. PMID: 27619726, PMCID: PMC5328942, PII: S0945-053X(16)30074-9, DOI: 10.1016/j.matbio.2016.09.005, ISSN: 1569-1802.

Añazco C, López-Jiménez AJ, Rafi M, Vega-Montoto L, Zhang MZ, Hudson BG, Vanacore RM. Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane. J. Biol. Chem [print-electronic]. 2016 Dec 12/9/2016; 291(50): 25999-6012. PMID: 27770022, PMCID: PMC5207071, PII: M116.738856, DOI: 10.1074/jbc.M116.738856, ISSN: 1083-351X.

Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R. Implications of the differing roles of the ß1 and ß3 transmembrane and cytoplasmic domains for integrin function. Elife. 2016 Dec 12/8/2016; 5: PMID: 27929375, PMCID: PMC5207772, DOI: 10.7554/eLife.18633, ISSN: 2050-084X.

Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG. Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy. Data Brief. 2016 Dec; 9: 931-9. PMID: 27896299, PMCID: PMC5118616, PII: S2352-3409(16)30660-6, DOI: 10.1016/j.dib.2016.10.033.

Cui Z, Zhao MH, Jia XY, Wang M, Hu SY, Wang SX, Yu F, Brown KL, Hudson BG, Pedchenko V. Antibodies to a5 chain of collagen IV are pathogenic in Goodpasture's disease. J. Autoimmun [print-electronic]. 2016 Jun; 70: 1-11. PMID: 27117167, PII: S0896-8411(16)30033-6, DOI: 10.1016/j.jaut.2016.04.001, ISSN: 1095-9157.

Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, Stothers C, Ero-Tolliver IA, McCall AS, Vanacore R, Bhave G, Santoro S, Blackwell TS, Zent R, Pozzi A, Hudson BG. Extracellular chloride signals collagen IV network assembly during basement membrane formation. J. Cell Biol. 2016 May 5/23/2016; 213(4): 479-94. PMID: 27216258, PMCID: PMC4878091, PII: jcb.201510065, DOI: 10.1083/jcb.201510065, ISSN: 1540-8140.

Basak T, Vega-Montoto L, Zimmerman LJ, Tabb DL, Hudson BG, Vanacore RM. Comprehensive Characterization of Glycosylation and Hydroxylation of Basement Membrane Collagen IV by High-Resolution Mass Spectrometry. J. Proteome Res [print-electronic]. 2016 Jan 1/4/2016; 15(1): 245-58. PMID: 26593852, PMCID: PMC4771517, DOI: 10.1021/acs.jproteome.5b00767, ISSN: 1535-3907.

Gessel M, Spraggins JM, Voziyan P, Hudson BG, Caprioli RM. Decellularization of intact tissue enables MALDI imaging mass spectrometry analysis of the extracellular matrix. J Mass Spectrom. 2015 Nov; 50(11): 1288-93. PMID: 26505774, PMCID: PMC5320948, DOI: 10.1002/jms.3696, ISSN: 1096-9888.

Ero-Tolliver IA, Hudson BG, Bhave G. The Ancient Immunoglobulin Domains of Peroxidasin Are Required to Form Sulfilimine Cross-links in Collagen IV. J. Biol. Chem [print-electronic]. 2015 Aug 8/28/2015; 290(35): 21741-8. PMID: 26178375, PMCID: PMC4571896, PII: M115.673996, DOI: 10.1074/jbc.M115.673996, ISSN: 1083-351X.

Brown KL, Darris C, Rose KL, Sanchez OA, Madu H, Avance J, Brooks N, Zhang MZ, Fogo A, Harris R, Hudson BG, Voziyan P. Hypohalous acids contribute to renal extracellular matrix damage in experimental diabetes. Diabetes [print-electronic]. 2015 Jun; 64(6): 2242-53. PMID: 25605804, PMCID: PMC4439565, PII: db14-1001, DOI: 10.2337/db14-1001, ISSN: 1939-327X.

Robertson WE, Rose KL, Hudson BG, Vanacore RM. Supramolecular organization of the a121-a565 collagen IV network. J. Biol. Chem [print-electronic]. 2014 Sep 9/12/2014; 289(37): 25601-10. PMID: 25006246, PMCID: PMC4162165, PII: M114.571844, DOI: 10.1074/jbc.M114.571844, ISSN: 1083-351X.

Grove KJ, Voziyan PA, Spraggins JM, Wang S, Paueksakon P, Harris RC, Hudson BG, Caprioli RM. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. J. Lipid Res [print-electronic]. 2014 Jul; 55(7): 1375-85. PMID: 24864273, PMCID: PMC4076088, PII: jlr.M049189, DOI: 10.1194/jlr.M049189, ISSN: 1539-7262.

Kohan DE, Parker MG, Furth SL, Hudson BG, Warburton KM, Rys-Sikora KE, Rankin TL, . Propagating the nephrology research workforce: a Kidney Research National Dialogue training commentary. Clin J Am Soc Nephrol [print-electronic]. 2014 Jun 6/6/2014; 9(6): 1144-7. PMID: 24626430, PMCID: PMC4046718, PII: CJN.01070114, DOI: 10.2215/CJN.01070114, ISSN: 1555-905X.

McCall AS, Cummings CF, Bhave G, Vanacore R, Page-McCaw A, Hudson BG. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. Cell. 2014 Jun 6/5/2014; 157(6): 1380-92. PMID: 24906154, PMCID: PMC4144415, PII: S0092-8674(14)00598-4, DOI: 10.1016/j.cell.2014.05.009, ISSN: 1097-4172.

Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT, , Hudson JK, Hudson BG. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Jan 1/7/2014; 111(1): 331-6. PMID: 24344311, PMCID: PMC3890831, PII: 1318499111, DOI: 10.1073/pnas.1318499111, ISSN: 1091-6490.

Cummings CF, Hudson BG. Lens capsule as a model to study type IV collagen. Connect. Tissue Res. 2014 Jan; 55(1): 8-12. PMID: 24437599, PMCID: PMC4138812, DOI: 10.3109/03008207.2013.867337, ISSN: 1607-8438.

Olaru F, Luo W, Wang XP, Ge L, Hertz JM, Kashtan CE, Sado Y, Segal Y, Hudson BG, Borza DB. Quaternary epitopes of a345(IV) collagen initiate Alport post-transplant anti-GBM nephritis. J. Am. Soc. Nephrol [print-electronic]. 2013 May; 24(6): 889-95. PMID: 23620401, PMCID: PMC3665397, PII: ASN.2012100978, DOI: 10.1681/ASN.2012100978, ISSN: 1533-3450.

Bhave G, Cummings CF, Vanacore RM, Kumagai-Cresse C, Ero-Tolliver IA, Rafi M, Kang JS, Pedchenko V, Fessler LI, Fessler JH, Hudson BG. Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis. Nat. Chem. Biol [print-electronic]. 2012 Sep; 8(9): 784-90. PMID: 22842973, PMCID: PMC4128002, PII: nchembio.1038, DOI: 10.1038/nchembio.1038, ISSN: 1552-4469.

Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. Inhibition of integrin a2ß1 ameliorates glomerular injury. J. Am. Soc. Nephrol [print-electronic]. 2012 Jun; 23(6): 1027-38. PMID: 22440900, PMCID: PMC3358756, PII: ASN.2011040367, DOI: 10.1681/ASN.2011040367, ISSN: 1533-3450.

Vanacore R, Pedchenko V, Bhave G, Hudson BG. Sulphilimine cross-links in Goodpasture's disease. Clin. Exp. Immunol. 2011 May; 164 Suppl 1: 4-6. PMID: 21447121, PMCID: PMC3095855, DOI: 10.1111/j.1365-2249.2011.04356.x, ISSN: 1365-2249.

Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching AR, Wieslander J, Kashtan C, Borza DB, Neilson EG, Wilson CB, Hudson BG. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N. Engl. J. Med. 2010 Jul 7/22/2010; 363(4): 343-54. PMID: 20660402, PMCID: PMC4144421, PII: 363/4/343, DOI: 10.1056/NEJMoa0910500, ISSN: 1533-4406.

Rebustini IT, Myers C, Lassiter KS, Surmak A, Szabova L, Holmbeck K, Pedchenko V, Hudson BG, Hoffman MP. MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. Dev. Cell. 2009 Oct; 17(4): 482-93. PMID: 19853562, PMCID: PMC2768621, PII: S1534-5807(09)00300-1, DOI: 10.1016/j.devcel.2009.07.016, ISSN: 1878-1551.

Pozzi A, Zent R, Chetyrkin S, Borza C, Bulus N, Chuang P, Chen D, Hudson B, Voziyan P. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. J. Am. Soc. Nephrol [print-electronic]. 2009 Oct; 20(10): 2119-25. PMID: 19608705, PMCID: PMC2754111, PII: ASN.2008080900, DOI: 10.1681/ASN.2008080900, ISSN: 1533-3450.

Thotala D, Chetyrkin S, Hudson B, Hallahan D, Voziyan P, Yazlovitskaya E. Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis. Free Radic. Biol. Med [print-electronic]. 2009 Sep 9/15/2009; 47(6): 779-85. PMID: 19540915, PMCID: PMC2739572, PII: S0891-5849(09)00367-0, DOI: 10.1016/j.freeradbiomed.2009.06.020, ISSN: 1873-4596.

Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG. A sulfilimine bond identified in collagen IV. Science. 2009 Sep 9/4/2009; 325(5945): 1230-4. PMID: 19729652, PMCID: PMC2876822, PII: 325/5945/1230, DOI: 10.1126/science.1176811, ISSN: 1095-9203.

Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL. Cellular origins of type IV collagen networks in developing glomeruli. J. Am. Soc. Nephrol [print-electronic]. 2009 Jul; 20(7): 1471-9. PMID: 19423686, PMCID: PMC2709682, PII: ASN.2008101086, DOI: 10.1681/ASN.2008101086, ISSN: 1533-3450.

Aggeli AS, Kitsiou PV, Tzinia AK, Boutaud A, Hudson BG, Tsilibary EC. Selective binding of integrins from different renal cell types to the NC1 domain of alpha3 and alpha1 chains of type IV collagen. J. Nephrol. 2009 Jan; 22(1): 130-6. PMID: 19229828, ISSN: 1121-8428.

Pozzi A, Voziyan PA, Hudson BG, Zent R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr. Pharm. Des. 2009; 15(12): 1318-33. PMID: 19355971, ISSN: 1873-4286.

Kang JS, Colon S, Hellmark T, Sado Y, Hudson BG, Borza DB. Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy. J. Biol. Chem [print-electronic]. 2008 Dec 12/12/2008; 283(50): 35070-7. PMID: 18930919, PMCID: PMC2596392, PII: M806396200, DOI: 10.1074/jbc.M806396200, ISSN: 0021-9258.

Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A, Zent R. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp. Cell Res [print-electronic]. 2008 Nov 11/15/2008; 314(19): 3593-604. PMID: 18809396, PMCID: PMC2729514, PII: S0014-4827(08)00328-5, DOI: 10.1016/j.yexcr.2008.08.014, ISSN: 1090-2422.

Vanacore RM, Ham AJ, Cartailler JP, Sundaramoorthy M, Todd P, Pedchenko V, Sado Y, Borza DB, Hudson BG. A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes. J. Biol. Chem [print-electronic]. 2008 Aug 8/15/2008; 283(33): 22737-48. PMID: 18499662, PMCID: PMC2504875, PII: M803451200, DOI: 10.1074/jbc.M803451200, ISSN: 0021-9258.

Granero-Moltó F, Sarmah S, O'Rear L, Spagnoli A, Abrahamson D, Saus J, Hudson BG, Knapik EW. Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development. J. Biol. Chem [print-electronic]. 2008 Jul 7/18/2008; 283(29): 20495-504. PMID: 18424781, PMCID: PMC2459293, PII: M801806200, DOI: 10.1074/jbc.M801806200, ISSN: 0021-9258.

Khoshnoodi J, Pedchenko V, Hudson BG. Mammalian collagen IV. Microsc. Res. Tech. 2008 May; 71(5): 357-70. PMID: 18219669, DOI: 10.1002/jemt.20564, ISSN: 1059-910X.

Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev. Biol [print-electronic]. 2008 Apr 4/15/2008; 316(2): 288-301. PMID: 18328474, PMCID: PMC2396524, PII: S0012-1606(08)00039-0, DOI: 10.1016/j.ydbio.2008.01.022, ISSN: 1095-564X.

Chetyrkin SV, Mathis ME, Ham AJ, Hachey DL, Hudson BG, Voziyan PA. Propagation of protein glycation damage involves modification of tryptophan residues via reactive oxygen species: inhibition by pyridoxamine. Free Radic. Biol. Med [print-electronic]. 2008 Apr 4/1/2008; 44(7): 1276-85. PMID: 18374270, PII: S0891-5849(07)00626-0, DOI: 10.1016/j.freeradbiomed.2007.09.016, ISSN: 0891-5849.

Borza CM, Borza DB, Pedchenko V, Saleem MA, Mathieson PW, Sado Y, Hudson HM, Pozzi A, Saus J, Abrahamson DR, Zent R, Hudson BG. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J. Am. Soc. Nephrol [print-electronic]. 2008 Apr; 19(4): 677-84. PMID: 18235087, PMCID: PMC2390958, PII: ASN.2007070793, DOI: 10.1681/ASN.2007070793, ISSN: 1533-3450.

Chetyrkin SV, Zhang W, Hudson BG, Serianni AS, Voziyan PA. Pyridoxamine protects proteins from functional damage by 3-deoxyglucosone: mechanism of action of pyridoxamine. Biochemistry [print-electronic]. 2008 Jan 1/22/2008; 47(3): 997-1006. PMID: 18161948, DOI: 10.1021/bi701190s, ISSN: 0006-2960.

Kang JS, Kashtan CE, Turner AN, Heidet L, Hudson BG, Borza DB. The alloantigenic sites of alpha3alpha4alpha5(IV) collagen: pathogenic X-linked alport alloantibodies target two accessible conformational epitopes in the alpha5NC1 domain. J. Biol. Chem [print-electronic]. 2007 Apr 4/6/2007; 282(14): 10670-7. PMID: 17293596, PII: M611892200, DOI: 10.1074/jbc.M611892200, ISSN: 0021-9258.

Fox MA, Sanes JR, Borza DB, Eswarakumar VP, Fässler R, Hudson BG, John SW, Ninomiya Y, Pedchenko V, Pfaff SL, Rheault MN, Sado Y, Segal Y, Werle MJ, Umemori H. Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. Cell. 2007 Apr 4/6/2007; 129(1): 179-93. PMID: 17418794, PII: S0092-8674(07)00302-9, DOI: 10.1016/j.cell.2007.02.035, ISSN: 0092-8674.

Steenhard BM, Freeburg PB, Isom K, Stroganova L, Borza DB, Hudson BG, St John PL, Zelenchuk A, Abrahamson DR. Kidney development and gene expression in the HIF2alpha knockout mouse. Dev. Dyn. 2007 Apr; 236(4): 1115-25. PMID: 17342756, DOI: 10.1002/dvdy.21106, ISSN: 1058-8388.

Khoshnoodi J, Hill S, Tryggvason K, Hudson B, Friedman DB. Identification of N-linked glycosylation sites in human nephrin using mass spectrometry. J Mass Spectrom. 2007 Mar; 42(3): 370-9. PMID: 17212372, DOI: 10.1002/jms.1170, ISSN: 1076-5174.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry [print-electronic]. 2006 Dec 12/26/2006; 45(51): 15756-67. PMID: 17176098, PMCID: PMC2597444, DOI: 10.1021/bi061860g, ISSN: 1520-4995.

Khoshnoodi J, Cartailler JP, Alvares K, Veis A, Hudson BG. Molecular recognition in the assembly of collagens: terminal noncollagenous domains are key recognition modules in the formation of triple helical protomers. J. Biol. Chem [print-electronic]. 2006 Dec 12/15/2006; 281(50): 38117-21. PMID: 17082192, PII: R600025200, DOI: 10.1074/jbc.R600025200, ISSN: 0021-9258.

Chen L, Hellmark T, Pedchenko V, Hudson BG, Pusey CD, Fox JW, Bolton WK. A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis. J. Am. Soc. Nephrol [print-electronic]. 2006 Nov; 17(11): 3076-81. PMID: 17005930, PII: ASN.2006070688, DOI: 10.1681/ASN.2006070688, ISSN: 1046-6673.

Miyoshi T, Hirohata S, Ogawa H, Doi M, Obika M, Yonezawa T, Sado Y, Kusachi S, Kyo S, Kondo S, Shiratori Y, Hudson BG, Ninomiya Y. Tumor-specific expression of the RGD-alpha3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice. FASEB J [print-electronic]. 2006 Sep; 20(11): 1904-6. PMID: 16877525, PII: fj.05-5565fje, DOI: 10.1096/fj.05-5565fje, ISSN: 1530-6860.

Zent R, Yan X, Su Y, Hudson BG, Borza DB, Moeckel GW, Qi Z, Sado Y, Breyer MD, Voziyan P, Pozzi A. Glomerular injury is exacerbated in diabetic integrin alpha1-null mice. Kidney Int [print-electronic]. 2006 Aug; 70(3): 460-70. PMID: 16775606, PII: 5000359, DOI: 10.1038/, ISSN: 0085-2538.

Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. J. Biol. Chem [print-electronic]. 2006 Jul 7/28/2006; 281(30): 20932-9. PMID: 16731529, PII: M601147200, DOI: 10.1074/jbc.M601147200, ISSN: 0021-9258.

Harvey SJ, Perry J, Zheng K, Chen D, Sado Y, Jefferson B, Ninomiya Y, Jacobs R, Hudson BG, Thorner PS. Sequential expression of type IV collagen networks: testis as a model and relevance to spermatogenesis. Am. J. Pathol. 2006 May; 168(5): 1587-97. PMID: 16651625, PMCID: PMC1606577, PII: S0002-9440(10)62181-5, DOI: 10.2353/ajpath.2006.050816, ISSN: 0002-9440.

Calvete JJ, Revert F, Blanco M, Cervera J, Tárrega C, Sanz L, Revert-Ros F, Granero F, Pérez-Payá E, Hudson BG, Saus J. Conformational diversity of the Goodpasture antigen, the noncollagenous-1 domain of the alpha3 chain of collagen IV. Proteomics. 2006 Apr; 6 Suppl 1: S237-44. PMID: 16534749, DOI: 10.1002/pmic.200500495, ISSN: 1615-9861.

Khoshnoodi J, Sigmundsson K, Cartailler JP, Bondar O, Sundaramoorthy M, Hudson BG. Mechanism of chain selection in the assembly of collagen IV: a prominent role for the alpha2 chain. J. Biol. Chem [print-electronic]. 2006 Mar 3/3/2006; 281(9): 6058-69. PMID: 16373348, PII: M506555200, DOI: 10.1074/jbc.M506555200, ISSN: 0021-9258.

Zheng K, Perry J, Harvey SJ, Sado Y, Ninomiya Y, Jefferson B, Jacobs R, Hudson BG, Thorner PS. Regulation of collagen type IV genes is organ-specific: evidence from a canine model of Alport syndrome. Kidney Int. 2005 Nov; 68(5): 2121-30. PMID: 16221211, PII: KID668, DOI: 10.1111/j.1523-1755.2005.00668.x, ISSN: 0085-2538.

Scheinman JI, Voziyan PA, Belmont JM, Chetyrkin SV, Kim D, Hudson BG. Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Urol. Res [print-electronic]. 2005 Nov; 33(5): 368-71. PMID: 16292584, DOI: 10.1007/s00240-005-0493-3, ISSN: 0300-5623.

Pedchenko VK, Chetyrkin SV, Chuang P, Ham AJ, Saleem MA, Mathieson PW, Hudson BG, Voziyan PA. Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy. Diabetes. 2005 Oct; 54(10): 2952-60. PMID: 16186398, PII: 54/10/2952, ISSN: 0012-1797.

Vanacore RM, Friedman DB, Ham AJ, Sundaramoorthy M, Hudson BG. Identification of S-hydroxylysyl-methionine as the covalent cross-link of the noncollagenous (NC1) hexamer of the alpha1alpha1alpha2 collagen IV network: a role for the post-translational modification of lysine 211 to hydroxylysine 211 in hexamer assembly. J. Biol. Chem [print-electronic]. 2005 Aug 8/12/2005; 280(32): 29300-10. PMID: 15951440, PII: M502752200, DOI: 10.1074/jbc.M502752200, ISSN: 0021-9258.

Voziyan PA, Hudson BG. Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage. Cell. Mol. Life Sci. 2005 Aug; 62(15): 1671-81. PMID: 15905958, DOI: 10.1007/s00018-005-5082-7, ISSN: 1420-682X.

Borza DB, Bondar O, Colon S, Todd P, Sado Y, Neilson EG, Hudson BG. Goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement: novel mechanisms for immune privilege and autoimmune pathogenesis. J. Biol. Chem [print-electronic]. 2005 Jul 7/22/2005; 280(29): 27147-54. PMID: 15917228, PII: M504050200, DOI: 10.1074/jbc.M504050200, ISSN: 0021-9258.

Voziyan PA, Hudson BG. Pyridoxamine: the many virtues of a maillard reaction inhibitor. Ann. N. Y. Acad. Sci. 2005 Jun; 1043: 807-16. PMID: 16037308, PII: 1043/1/807, DOI: 10.1196/annals.1333.093, ISSN: 0077-8923.

Dean EG, Wilson GR, Li M, Edgtton KL, O'Sullivan KM, Hudson BG, Holdsworth SR, Kitching AR. Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury. Kidney Int. 2005 Feb; 67(2): 566-75. PMID: 15673304, PII: KID67113, DOI: 10.1111/j.1523-1755.2005.67113.x, ISSN: 0085-2538.

Chetyrkin SV, Kim D, Belmont JM, Scheinman JI, Hudson BG, Voziyan PA. Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria. Kidney Int. 2005 Jan; 67(1): 53-60. PMID: 15610227, PII: KID054, DOI: 10.1111/j.1523-1755.2005.00054.x, ISSN: 0085-2538.

Vanacore RM, Shanmugasundararaj S, Friedman DB, Bondar O, Hudson BG, Sundaramoorthy M. The alpha1.alpha2 network of collagen IV. Reinforced stabilization of the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links. J. Biol. Chem [print-electronic]. 2004 Oct 10/22/2004; 279(43): 44723-30. PMID: 15299013, PII: M406344200, DOI: 10.1074/jbc.M406344200, ISSN: 0021-9258.

Hudson BG. The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family. J. Am. Soc. Nephrol. 2004 Oct; 15(10): 2514-27. PMID: 15466256, PII: 15/10/2514, DOI: 10.1097/01.ASN.0000141462.00630.76, ISSN: 1046-6673.

Kitching AR, Turner AL, Semple T, Li M, Edgtton KL, Wilson GR, Timoshanko JR, Hudson BG, Holdsworth SR. Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma. J. Am. Soc. Nephrol. 2004 Jul; 15(7): 1764-74. PMID: 15213264, ISSN: 1046-6673.

Pedchenko V, Zent R, Hudson BG. Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion. J. Biol. Chem [print-electronic]. 2004 Jan 1/23/2004; 279(4): 2772-80. PMID: 14610079, PII: M311901200, DOI: 10.1074/jbc.M311901200, ISSN: 0021-9258.

Voziyan PA, Khalifah RG, Thibaudeau C, Yildiz A, Jacob J, Serianni AS, Hudson BG. Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions. J. Biol. Chem [print-electronic]. 2003 Nov 11/21/2003; 278(47): 46616-24. PMID: 12975371, PII: M307155200, DOI: 10.1074/jbc.M307155200, ISSN: 0021-9258.

Borza DB, Neilson EG, Hudson BG. Pathogenesis of Goodpasture syndrome: a molecular perspective. Semin. Nephrol. 2003 Nov; 23(6): 522-31. PMID: 14631560, PII: S0270929503001311, ISSN: 0270-9295.

Heidet L, Borza DB, Jouin M, Sich M, Mattei MG, Sado Y, Hudson BG, Hastie N, Antignac C, Gubler MC. A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice. Am. J. Pathol. 2003 Oct; 163(4): 1633-44. PMID: 14507670, PMCID: PMC1868284, PII: S0002-9440(10)63520-1, ISSN: 0002-9440.

Cussimanio BL, Booth AA, Todd P, Hudson BG, Khalifah RG. Unusual susceptibility of heme proteins to damage by glucose during non-enzymatic glycation. Biophys. Chem. 2003 Sep; 105(2-3): 743-55. PMID: 14499930, PII: S0301462203001005, ISSN: 0301-4622.

Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N. Engl. J. Med. 2003 Jun 6/19/2003; 348(25): 2543-56. PMID: 12815141, PII: 348/25/2543, DOI: 10.1056/NEJMra022296, ISSN: 1533-4406.

Borza DB, Hudson BG. Molecular characterization of the target antigens of anti-glomerular basement membrane antibody disease. Springer Semin. Immunopathol. 2003 May; 24(4): 345-61. PMID: 12778332, DOI: 10.1007/s00281-002-0103-1, ISSN: 0344-4325.

Borza DB, Bondar O, Todd P, Sundaramoorthy M, Sado Y, Ninomiya Y, Hudson BG. Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains. J. Biol. Chem [print-electronic]. 2002 Oct 10/18/2002; 277(42): 40075-83. PMID: 12193605, PII: M207769200, DOI: 10.1074/jbc.M207769200, ISSN: 0021-9258.

Sundaramoorthy M, Meiyappan M, Todd P, Hudson BG. Crystal structure of NC1 domains. Structural basis for type IV collagen assembly in basement membranes. J. Biol. Chem [print-electronic]. 2002 Aug 8/23/2002; 277(34): 31142-53. PMID: 11970952, PII: M201740200, DOI: 10.1074/jbc.M201740200, ISSN: 0021-9258.

Borza DB, Hudson BG. Of mice and men: murine models of anti-GBM antibody nephritis [editorial]. Kidney Int. 2002 May; 61(5): 1905-6. PMID: 11967044, PII: kid340, DOI: 10.1046/j.1523-1755.2002.00340.x, ISSN: 0085-2538.

Voziyan PA, Metz TO, Baynes JW, Hudson BG. A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation. J. Biol. Chem [print-electronic]. 2002 Feb 2/1/2002; 277(5): 3397-403. PMID: 11729198, PII: M109935200, DOI: 10.1074/jbc.M109935200, ISSN: 0021-9258.

Borza DB, Bondar O, Ninomiya Y, Sado Y, Naito I, Todd P, Hudson BG. The NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranes. J. Biol. Chem [print-electronic]. 2001 Jul 7/27/2001; 276(30): 28532-40. PMID: 11375996, PII: M103690200, DOI: 10.1074/jbc.M103690200, ISSN: 0021-9258.

David M, Borza DB, Leinonen A, Belmont JM, Hudson BG. Hydrophobic amino acid residues are critical for the immunodominant epitope of the Goodpasture autoantigen. A molecular basis for the cryptic nature of the epitope. J. Biol. Chem [print-electronic]. 2001 Mar 3/2/2001; 276(9): 6370-7. PMID: 11098057, PII: M008956200, DOI: 10.1074/jbc.M008956200, ISSN: 0021-9258.

Boutaud A, Borza DB, Bondar O, Gunwar S, Netzer KO, Singh N, Ninomiya Y, Sado Y, Noelken ME, Hudson BG. Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domains. J. Biol. Chem. 2000 Sep 9/29/2000; 275(39): 30716-24. PMID: 10896941, PII: M004569200, DOI: 10.1074/jbc.M004569200, ISSN: 0021-9258.

Ghohestani RF, Hudson BG, Claudy A, Uitto J. The alpha 5 chain of type IV collagen is the target of IgG autoantibodies in a novel autoimmune disease with subepidermal blisters and renal insufficiency. J. Biol. Chem. 2000 May 5/26/2000; 275(21): 16002-6. PMID: 10821854, PII: 275/21/16002, ISSN: 0021-9258.

Petitclerc E, Boutaud A, Prestayko A, Xu J, Sado Y, Ninomiya Y, Sarras MP, Hudson BG, Brooks PC. New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo. J. Biol. Chem. 2000 Mar 3/17/2000; 275(11): 8051-61. PMID: 10713126, ISSN: 0021-9258.

Borza DB, Netzer KO, Leinonen A, Todd P, Cervera J, Saus J, Hudson BG. The goodpasture autoantigen. Identification of multiple cryptic epitopes on the NC1 domain of the alpha3(IV) collagen chain. J. Biol. Chem. 2000 Feb 2/25/2000; 275(8): 6030-7. PMID: 10681598, ISSN: 0021-9258.

Fervenza FC, Terreros D, Boutaud A, Hudson BG, Williams RA, Donadio JV, Schwab TR. Recurrent Goodpasture's disease due to a monoclonal IgA-kappa circulating antibody. Am. J. Kidney Dis. 1999 Sep; 34(3): 549-55. PMID: 10469867, PII: S0272-6386(99)70084-3, DOI: 10.1053/AJKD03400549, ISSN: 1523-6838.

Netzer KO, Leinonen A, Boutaud A, Borza DB, Todd P, Gunwar S, Langeveld JP, Hudson BG. The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain. J. Biol. Chem. 1999 Apr 4/16/1999; 274(16): 11267-74. PMID: 10196215, ISSN: 0021-9258.

Khalifah RG, Baynes JW, Hudson BG. Amadorins: novel post-Amadori inhibitors of advanced glycation reactions. Biochem. Biophys. Res. Commun. 1999 Apr 4/13/1999; 257(2): 251-8. PMID: 10198198, PII: S0006-291X(99)90371-6, DOI: 10.1006/bbrc.1999.0371, ISSN: 0006-291X.

Leinonen A, Netzer KO, Boutaud A, Gunwar S, Hudson BG. Goodpasture antigen: expression of the full-length alpha3(IV) chain of collagen IV and localization of epitopes exclusively to the noncollagenous domain. Kidney Int. 1999 Mar; 55(3): 926-35. PMID: 10027929, DOI: 10.1046/j.1523-1755.1999.055003926.x, ISSN: 0085-2538.

Harvey SJ, Zheng K, Sado Y, Naito I, Ninomiya Y, Jacobs RM, Hudson BG, Thorner PS. Role of distinct type IV collagen networks in glomerular development and function. Kidney Int. 1998 Dec; 54(6): 1857-66. PMID: 9853250, DOI: 10.1046/j.1523-1755.1998.00188.x, ISSN: 0085-2538.

Abbate M, Kalluri R, Corna D, Yamaguchi N, McCluskey RT, Hudson BG, Andres G, Zoja C, Remuzzi G. Experimental Goodpasture's syndrome in Wistar-Kyoto rats immunized with alpha3 chain of type IV collagen. Kidney Int. 1998 Nov; 54(5): 1550-61. PMID: 9844131, DOI: 10.1046/j.1523-1755.1998.00153.x, ISSN: 0085-2538.

Netzer KO, Suzuki K, Itoh Y, Hudson BG, Khalifah RG. Comparative analysis of the noncollagenous NC1 domain of type IV collagen: identification of structural features important for assembly, function, and pathogenesis. Protein Sci. 1998 Jun; 7(6): 1340-51. PMID: 9655338, PMCID: PMC2144033, DOI: 10.1002/pro.5560070610, ISSN: 0961-8368.

Gunwar S, Ballester F, Noelken ME, Sado Y, Ninomiya Y, Hudson BG. Glomerular basement membrane. Identification of a novel disulfide-cross-linked network of alpha3, alpha4, and alpha5 chains of type IV collagen and its implications for the pathogenesis of Alport syndrome. J. Biol. Chem. 1998 Apr 4/10/1998; 273(15): 8767-75. PMID: 9535854, ISSN: 0021-9258.

Sado Y, Boutaud A, Kagawa M, Naito I, Ninomiya Y, Hudson BG. Induction of anti-GBM nephritis in rats by recombinant alpha 3(IV)NC1 and alpha 4(IV)NC1 of type IV collagen. Kidney Int. 1998 Mar; 53(3): 664-71. PMID: 9507212, DOI: 10.1046/j.1523-1755.1998.00795.x, ISSN: 0085-2538.

Kalluri R, Gattone VH, Hudson BG. Identification and localization of type IV collagen chains in the inner ear cochlea. Connect. Tissue Res. 1998; 37(1-2): 143-50. PMID: 9643653, ISSN: 0300-8207.

Mott JD, Khalifah RG, Nagase H, Shield CF, Hudson JK, Hudson BG. Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility. Kidney Int. 1997 Nov; 52(5): 1302-12. PMID: 9350653, ISSN: 0085-2538.

Kahsai TZ, Enders GC, Gunwar S, Brunmark C, Wieslander J, Kalluri R, Zhou J, Noelken ME, Hudson BG. Seminiferous tubule basement membrane. Composition and organization of type IV collagen chains, and the linkage of alpha3(IV) and alpha5(IV) chains. J. Biol. Chem. 1997 Jul 7/4/1997; 272(27): 17023-32. PMID: 9202017, ISSN: 0021-9258.

Kalluri R, Shield CF, Todd P, Hudson BG, Neilson EG. Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis. J. Clin. Invest. 1997 May 5/15/1997; 99(10): 2470-8. PMID: 9153291, PMCID: PMC508088, DOI: 10.1172/JCI119431, ISSN: 0021-9738.

Booth AA, Khalifah RG, Todd P, Hudson BG. In vitro kinetic studies of formation of antigenic advanced glycation end products (AGEs). Novel inhibition of post-Amadori glycation pathways. J. Biol. Chem. 1997 Feb 2/28/1997; 272(9): 5430-7. PMID: 9038143, ISSN: 0021-9258.

Cheung WF, van den Born J, Kühn K, Kjellén L, Hudson BG, Stafford DW. Identification of the endothelial cell binding site for factor IX. Proc. Natl. Acad. Sci. U.S.A. 1996 Oct 10/1/1996; 93(20): 11068-73. PMID: 8855310, PMCID: PMC38285, ISSN: 0027-8424.

Boutaud AA, Kalluri R, Kahsai TZ, Noelken ME, Hudson BG. Goodpasture syndrome: selective removal of anti-alpha 3 (IV) collagen autoantibodies. A potential therapeutic alternative to plasmapheresis. Exp. Nephrol. 1996 Jul; 4(4): 205-12. PMID: 8864724, ISSN: 1018-7782.

Thorner PS, Zheng K, Kalluri R, Jacobs R, Hudson BG. Coordinate gene expression of the alpha3, alpha4, and alpha5 chains of collagen type IV. Evidence from a canine model of X-linked nephritis with a COL4A5 gene mutation. J. Biol. Chem. 1996 Jun 6/7/1996; 271(23): 13821-8. PMID: 8662866, ISSN: 0021-9258.

Khalifah RG, Todd P, Booth AA, Yang SX, Mott JD, Hudson BG. Kinetics of nonenzymatic glycation of ribonuclease A leading to advanced glycation end products. Paradoxical inhibition by ribose leads to facile isolation of protein intermediate for rapid post-Amadori studies. Biochemistry. 1996 Apr 4/16/1996; 35(15): 4645-54. PMID: 8664253, PII: bi9525942, DOI: 10.1021/bi9525942, ISSN: 0006-2960.

Kalluri R, Sun MJ, Hudson BG, Neilson EG. The Goodpasture autoantigen. Structural delineation of two immunologically privileged epitopes on alpha3(IV) chain of type IV collagen. J. Biol. Chem. 1996 Apr 4/12/1996; 271(15): 9062-8. PMID: 8621555, ISSN: 0021-9258.

Merkel F, Kalluri R, Marx M, Enders U, Stevanovic S, Giegerich G, Neilson EG, Rammensee HG, Hudson BG, Weber M. Autoreactive T-cells in Goodpasture's syndrome recognize the N-terminal NC1 domain on alpha 3 type IV collagen. Kidney Int. 1996 Apr; 49(4): 1127-33. PMID: 8691734, ISSN: 0085-2538.

Booth AA, Khalifah RG, Hudson BG. Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine. Biochem. Biophys. Res. Commun. 1996 Mar 3/7/1996; 220(1): 113-9. PMID: 8602828, PII: S0006-291X(96)90366-6, DOI: 10.1006/bbrc.1996.0366, ISSN: 0006-291X.

Enders GC, Kahsai TZ, Lian G, Funabiki K, Killen PD, Hudson BG. Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis. Biol. Reprod. 1995 Dec; 53(6): 1489-99. PMID: 8562707, ISSN: 0006-3363.

Kalluri R, Wilson CB, Weber M, Gunwar S, Chonko AM, Neilson EG, Hudson BG. Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome. J. Am. Soc. Nephrol. 1995 Oct; 6(4): 1178-85. PMID: 8589284, ISSN: 1046-6673.

Peissel B, Geng L, Kalluri R, Kashtan C, Rennke HG, Gallo GR, Yoshioka K, Sun MJ, Hudson BG, Neilson EG. Comparative distribution of the alpha 1(IV), alpha 5(IV), and alpha 6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients. J. Clin. Invest. 1995 Oct; 96(4): 1948-57. PMID: 7560087, PMCID: PMC185832, DOI: 10.1172/JCI118241, ISSN: 0021-9738.

Kalluri R, van den Heuvel LP, Smeets HJ, Schroder CH, Lemmink HH, Boutaud A, Neilson EG, Hudson BG. A COL4A3 gene mutation and post-transplant anti-alpha 3(IV) collagen alloantibodies in Alport syndrome. Kidney Int. 1995 Apr; 47(4): 1199-204. PMID: 7783419, ISSN: 0085-2538.

Zhang X, Hudson BG, Sarras MP. Hydra cell aggregate development is blocked by selective fragments of fibronectin and type IV collagen. Dev. Biol. 1994 Jul; 164(1): 10-23. PMID: 8026615, PII: S0012-1606(84)71176-6, DOI: 10.1006/dbio.1994.1176, ISSN: 0012-1606.

Kalluri R, Gattone VH, Noelken ME, Hudson BG. The alpha 3 chain of type IV collagen induces autoimmune Goodpasture syndrome. Proc. Natl. Acad. Sci. U.S.A. 1994 Jun 6/21/1994; 91(13): 6201-5. PMID: 8016138, PMCID: PMC44166, ISSN: 0027-8424.

Hudson BG, Kalluri R, Tryggvason K. Pathology of glomerular basement membrane nephropathy. Curr. Opin. Nephrol. Hypertens. 1994 May; 3(3): 334-9. PMID: 7922261, ISSN: 1062-4821.

Kalluri R, Weber M, Netzer KO, Sun MJ, Neilson EG, Hudson BG. COL4A5 gene deletion and production of post-transplant anti-alpha 3(IV) collagen alloantibodies in Alport syndrome. Kidney Int. 1994 Mar; 45(3): 721-6. PMID: 8196274, ISSN: 0085-2538.

Baynes RD, Shih YJ, Hudson BG, Cook JD. Identification of the membrane remnants of transferrin receptor with domain-specific antibodies. J. Lab. Clin. Med. 1994 Mar; 123(3): 407-14. PMID: 8133153, ISSN: 0022-2143.

Noelken ME, Reddy GK, Kalluri R, Gunwar S, Hudson BG. The chain composition of aorta basement membrane collagen IV, localization of the chains in aorta and supramolecular assembly of the collagen IV protomers. Contrib Nephrol. 1994; 107: 216-9. PMID: 8004971, ISSN: 0302-5144.

Hudson BG, Kalluri R, Gunwar S, Noelken ME. Structure and organization of type IV collagen of renal glomerular basement membrane. Contrib Nephrol. 1994; 107: 163-7. PMID: 8004963, ISSN: 0302-5144.

Hudson BG, Reeders ST, Tryggvason K. Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. J. Biol. Chem. 1993 Dec 12/15/1993; 268(35): 26033-6. PMID: 8253711, ISSN: 0021-9258.

Baynes RD, Shih YJ, Hudson BG, Cook JD. Production of the serum form of the transferrin receptor by a cell membrane-associated serine protease. Proc. Soc. Exp. Biol. Med. 1993 Oct; 204(1): 65-9. PMID: 8372098, ISSN: 0037-9727.

Reddy GK, Gunwar S, Kalluri R, Hudson BG, Noelken ME. Structure and composition of type IV collagen of bovine aorta. Biochim. Biophys. Acta. 1993 Jul 7/11/1993; 1157(3): 241-51. PMID: 8323954, ISSN: 0006-3002.

Neilson EG, Kalluri R, Sun MJ, Gunwar S, Danoff T, Mariyama M, Myers JC, Reeders ST, Hudson BG. Specificity of Goodpasture autoantibodies for the recombinant noncollagenous domains of human type IV collagen. J. Biol. Chem. 1993 Apr 4/25/1993; 268(12): 8402-5. PMID: 8473281, ISSN: 0021-9258.

Reddy GK, Hudson BG, Bailey AJ, Noelken ME. Reductive cleavage of the disulfide bonds of the collagen IV noncollagenous domain in aqueous sodium dodecyl sulfate: absence of intermolecular nondisulfide cross-links. Biochem. Biophys. Res. Commun. 1993 Jan 1/15/1993; 190(1): 277-82. PMID: 8422253, PII: S0006-291X(83)71042-9, DOI: 10.1006/bbrc.1993.1042, ISSN: 0006-291X.

Shih YJ, Baynes RD, Hudson BG, Cook JD. Characterization and quantitation of the circulating forms of serum transferrin receptor using domain-specific antibodies. Blood. 1993 Jan 1/1/1993; 81(1): 234-8. PMID: 8417792, ISSN: 0006-4971.

Hudson BG, Kalluri R, Gunwar S, Noelken ME, Mariyama M, Reeders ST. Molecular characteristics of the Goodpasture autoantigen. Kidney Int. 1993 Jan; 43(1): 135-9. PMID: 7679455, ISSN: 0085-2538.

Hudson BG, Kalluri R, Gunwar S, Weber M, Ballester F, Hudson JK, Noelken ME, Sarras M, Richardson WR, Saus J. The pathogenesis of Alport syndrome involves type IV collagen molecules containing the alpha 3(IV) chain: evidence from anti-GBM nephritis after renal transplantation. Kidney Int. 1992 Jul; 42(1): 179-87. PMID: 1635348, ISSN: 0085-2538.

Mariyama M, Kalluri R, Hudson BG, Reeders ST. The alpha 4(IV) chain of basement membrane collagen. Isolation of cDNAs encoding bovine alpha 4(IV) and comparison with other type IV collagens. J. Biol. Chem. 1992 Jan 1/15/1992; 267(2): 1253-8. PMID: 1370461, ISSN: 0021-9258.

Wisdom BJ, Gunwar S, Hudson MD, Noelken ME, Hudson BG. Type IV collagen of Engelbreth-Holm-Swarm tumor matrix: identification of constituent chains. Connect. Tissue Res. 1992; 27(4): 225-34. PMID: 1576823, ISSN: 0300-8207.

Kalluri R, Gunwar S, Reeders ST, Morrison KC, Mariyama M, Ebner KE, Noelken ME, Hudson BG. Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the alpha 3(IV) chain of basement membrane collagen. J. Biol. Chem. 1991 Dec 12/15/1991; 266(35): 24018-24. PMID: 1721062, ISSN: 0021-9258.

Sarras MP, Madden ME, Zhang XM, Gunwar S, Huff JK, Hudson BG. Extracellular matrix (mesoglea) of Hydra vulgaris. I. Isolation and characterization. Dev. Biol. 1991 Dec; 148(2): 481-94. PMID: 1743396, ISSN: 0012-1606.

Baynes RD, Shih YJ, Hudson BG, Cook JD. Characterization of transferrin receptor released by K562 erythroleukemia cells. Proc. Soc. Exp. Biol. Med. 1991 Sep; 197(4): 416-23. PMID: 1871153, ISSN: 0037-9727.

Gunwar S, Ballester F, Kalluri R, Timoneda J, Chonko AM, Edwards SJ, Noelken ME, Hudson BG. Glomerular basement membrane. Identification of dimeric subunits of the noncollagenous domain (hexamer) of collagen IV and the Goodpasture antigen. J. Biol. Chem. 1991 Aug 8/15/1991; 266(23): 15318-24. PMID: 1869555, ISSN: 0021-9258.

Gunwar S, Bejarano PA, Kalluri R, Langeveld JP, Wisdom BJ, Noelken ME, Hudson BG. Alveolar basement membrane: molecular properties of the noncollagenous domain (hexamer) of collagen IV and its reactivity with Goodpasture autoantibodies. Am. J. Respir. Cell Mol. Biol. 1991 Aug; 5(2): 107-12. PMID: 1892641, ISSN: 1044-1549.

Gunwar S, Noelken ME, Hudson BG. Properties of the collagenous domain of the alpha 3(IV) chain, the Goodpasture antigen, of lens basement membrane collagen. Selective cleavage of alpha (IV) chains with retention of their triple helical structure and noncollagenous domain. J. Biol. Chem. 1991 Jul 7/25/1991; 266(21): 14088-94. PMID: 1856232, ISSN: 0021-9258.

Langeveld JP, Noelken ME, Hård K, Todd P, Vliegenthart JF, Rouse J, Hudson BG. Bovine glomerular basement membrane. Location and structure of the asparagine-linked oligosaccharide units and their potential role in the assembly of the 7 S collagen IV tetramer. J. Biol. Chem. 1991 Feb 2/5/1991; 266(4): 2622-31. PMID: 1990011, ISSN: 0021-9258.

Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD. Serum transferrin receptor is a truncated form of tissue receptor. J. Biol. Chem. 1990 Nov 11/5/1990; 265(31): 19077-81. PMID: 2229063, ISSN: 0021-9258.

Zhang X, Huff JK, Hudson BG, Sarras MP. A non-mammalian in vivo model for cellular and molecular analysis of glucose-mediated thickening of basement membranes. Diabetologia. 1990 Nov; 33(11): 704-7. PMID: 2076802, ISSN: 0012-186X.

Fagg WR, Timoneda J, Schwartz CE, Langeveld JP, Noelken ME, Hudson BG. Glomerular basement membrane: evidence for collagenous domain of the alpha 3 and alpha 4 chains of collagen IV. Biochem. Biophys. Res. Commun. 1990 Jul 7/16/1990; 170(1): 322-7. PMID: 2372295, ISSN: 0006-291X.

Gunwar S, Saus J, Noelken ME, Hudson BG. Glomerular basement membrane. Identification of a fourth chain, alpha 4, of type IV collagen. J. Biol. Chem. 1990 Apr 4/5/1990; 265(10): 5466-9. PMID: 2318822, ISSN: 0021-9258.

Timoneda J, Gunwar S, Monfort G, Saus J, Noelken ME, Hudson BG. Unusual dissociative behavior of the noncollagenous domain (hexamer) of basement membrane collagen during electrophoresis and chromatofocusing. Connect. Tissue Res. 1990; 24(3-4): 169-86. PMID: 2376121, ISSN: 0300-8207.

Bejarano PA, Langeveld JP, Hudson BG, Noelken ME. Degradation of basement membranes by Pseudomonas aeruginosa elastase. Infect. Immun. 1989 Dec; 57(12): 3783-7. PMID: 2509368, PMCID: PMC259905, ISSN: 0019-9567.

Hudson BG, Wieslander J, Wisdom BJ, Noelken ME. Goodpasture syndrome: molecular architecture and function of basement membrane antigen. Lab. Invest. 1989 Sep; 61(3): 256-69. PMID: 2671489, ISSN: 0023-6837.

Bejarano PA, Noelken ME, Suzuki K, Hudson BG, Nagase H. Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin). Biochem. J. 1988 Dec 12/1/1988; 256(2): 413-9. PMID: 3223920, PMCID: PMC1135425, ISSN: 0264-6021.

Saus J, Wieslander J, Langeveld JP, Quinones S, Hudson BG. Identification of the Goodpasture antigen as the alpha 3(IV) chain of collagen IV. J. Biol. Chem. 1988 Sep 9/15/1988; 263(26): 13374-80. PMID: 3417661, ISSN: 0021-9258.

Langeveld JP, Wieslander J, Timoneda J, McKinney P, Butkowski RJ, Wisdom BJ, Hudson BG. Structural heterogeneity of the noncollagenous domain of basement membrane collagen. J. Biol. Chem. 1988 Jul 7/25/1988; 263(21): 10481-8. PMID: 3392020, ISSN: 0021-9258.

Wieslander J, Kataja M, Hudson BG. Characterization of the human Goodpasture antigen. Clin. Exp. Immunol. 1987 Aug; 69(2): 332-40. PMID: 3652534, PMCID: PMC1542417, ISSN: 0009-9104.

Butkowski RJ, Langeveld JP, Wieslander J, Hamilton J, Hudson BG. Localization of the Goodpasture epitope to a novel chain of basement membrane collagen. J. Biol. Chem. 1987 Jun 6/5/1987; 262(16): 7874-7. PMID: 2438283, ISSN: 0021-9258.

Noelken ME, Wisdom BJ, Dean DC, Hung CH, Hudson BG. Intestinal basement membrane of Ascaris suum. Molecular organization and properties of the collagen molecules. J. Biol. Chem. 1986 Apr 4/5/1986; 261(10): 4706-14. PMID: 3957913, ISSN: 0021-9258.

Butkowski RJ, Carone FA, Grantham JJ, Hudson BG. Tubular basement membrane changes in 2-amino-4,5-diphenylthiazole-induced polycystic disease. Kidney Int. 1985 Nov; 28(5): 744-51. PMID: 4087690, ISSN: 0085-2538.

Wieslander J, Langeveld J, Butkowski R, Jodlowski M, Noelken M, Hudson BG. Physical and immunochemical studies of the globular domain of type IV collagen. Cryptic properties of the Goodpasture antigen. J. Biol. Chem. 1985 Jul 7/15/1985; 260(14): 8564-70. PMID: 2409091, ISSN: 0021-9258.

Butkowski RJ, Wieslander J, Wisdom BJ, Barr JF, Noelken ME, Hudson BG. Properties of the globular domain of type IV collagen and its relationship to the Goodpasture antigen. J. Biol. Chem. 1985 Mar 3/25/1985; 260(6): 3739-47. PMID: 2982876, ISSN: 0021-9258.

Wieslander J, Barr JF, Butkowski RJ, Edwards SJ, Bygren P, Heinegård D, Hudson BG. Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen. Proc. Natl. Acad. Sci. U.S.A. 1984 Jun; 81(12): 3838-42. PMID: 6328527, PMCID: PMC345316, ISSN: 0027-8424.

Brieden HC, Good ED, Hudson BG, Mishelevich DJ, Mize EI, Robinson AL, Rogers C. The Parkland On-Line Information System (POIS) associate concept. Comput Healthc. 1983 Sep; 4(9): 40-4. PMID: 10262196, ISSN: 0745-1075.

Dean DC, Barr JF, Freytag JW, Hudson BG. Isolation of type IV procollagen-like polypeptides from glomerular basement membrane. Characterization of pro-alpha 1(IV). J. Biol. Chem. 1983 Jan 1/10/1983; 258(1): 590-6. PMID: 6294114, ISSN: 0021-9258.

Mishelevich DJ, Kesinger G, Jasper M, Inga P, Robinson AL, Gaige W, Hudson BG, Tyler N. Medical record control and the computer. Top Health Rec Manage. 1981 Dec; 2(2): 47-55. PMID: 10253964, ISSN: 0270-5230.

Fox JW, Butkowski RJ, Hudson BG. Detergent-prepared glomerular basement membrane is composed of a heterogeneous group of polypeptides. J. Biol. Chem. 1981 Sep 9/10/1981; 256(17): 9313-5. PMID: 7263717, ISSN: 0021-9258.

Butkowski RJ, Brungardt GS, Grantham JJ, Hudson BG. Characterization of the collagenous domain of tubular basement membrane. J. Biol. Chem. 1981 Jul 7/25/1981; 256(14): 7603-9. PMID: 7251611, ISSN: 0021-9258.

Dean DC, Peczon BD, Noelken ME, Hudson BG. Bovine glomerular basement membrane. Characterization of an alpha-size collagenous polypeptide. J. Biol. Chem. 1981 Jul 7/25/1981; 256(14): 7543-8. PMID: 7251609, ISSN: 0021-9258.

Hung CH, Noelken ME, Hudson BG. Intestinal basement membrane of Ascaris suum. Physical properties of the collagenous domain. J. Biol. Chem. 1981 Apr 4/25/1981; 256(8): 3822-6. PMID: 6783646, ISSN: 0021-9258.

Noelken ME, Wisdom BJ, Hudson BG. Estimation of the size of collagenous polypeptides by sodium dodecyl sulfate--polyacrylamide gel electrophoresis. Anal. Biochem. 1981 Jan 1/1/1981; 110(1): 131-6. PMID: 7212256, PII: 0003-2697(81)90123-8, ISSN: 0003-2697.

West TW, Fox JW, Jodlowski M, Freytag JW, Hudson BG. Bovine glomerular basement membrane. Properties of the collagenous domain. J. Biol. Chem. 1980 Nov 11/10/1980; 255(21): 10451-9. PMID: 6776117, ISSN: 0021-9258.

Hung CH, Butkowski RJ, Hudson BG. Intestinal basement membrane of Ascaris suum. Properties of the collagenous domain. J. Biol. Chem. 1980 May 5/25/1980; 255(10): 4964-71. PMID: 6768727, ISSN: 0021-9258.

Prasad R, Hudson BG, Strickland DK, Ebner KE. The structure of the asparagine-linked carbohydrate unit of rat alpha-lactalbumin. J. Biol. Chem. 1980 Feb 2/25/1980; 255(4): 1248-51. PMID: 7354024, ISSN: 0021-9258.

Peczon BD, Peczon JD, Cintron C, Hudson BG. Changes in chemical composition of anterior lens capsules of cataractous human eyes as a function of age. Exp. Eye Res. 1980 Feb; 30(2): 155-65. PMID: 7418737, ISSN: 0014-4835.

Butkowski RJ, Grantham JJ, Hudson BG. Comparison of the chemical and polypeptide composition of tubular and glomerular basement membranes. Ren Physiol. 1980; 3(1-6): 14-22. PMID: 7323408, ISSN: 0378-5858.

Hudson BG, Fox JW. Characterization of the collagenous domain of bovine glomerular basement membrane. Ren Physiol. 1980; 3(1-6): 9-13. PMID: 6798651, ISSN: 0378-5858.

Davis JL, Chandler DK, Riquetti P, Rogers S, Kocan KM, Ownby CL, Hudson BG, Carraway KL. Interaction of bovine platelets with bovine glomerular basement membrane. Thromb. Haemost. 1979 Dec 12/21/1979; 42(4): 1217-29. PMID: 542930, ISSN: 0340-6245.

Prasad R, Hudson BG, Butkowski R, Hamilton JW, Ebner KE. Resolution of the charge forms and amino acid sequence and location of a tryptic glycopeptide in rat alpha-lactalbumin. J. Biol. Chem. 1979 Nov 11/10/1979; 254(21): 10607-14. PMID: 500599, ISSN: 0021-9258.

Leung CC, Hung CH, Hudson BG, Brent RL, Cotton RC. Congenital abnormalities induced by heterologous antisera directed against rat kidney glycoproteins isolated by concanavalin A affinity chromatography. Pediatr. Res. 1979 Nov; 13(11): 1211-6. PMID: 316126, ISSN: 0031-3998.

Butkowski RJ, Todd P, Grantham JJ, Hudson BG. Rabbit tubular basement membrane. Isolation and analysis of polypeptides. J. Biol. Chem. 1979 Oct 10/25/1979; 254(20): 10503-13. PMID: 489609, ISSN: 0021-9258.

Freytag JW, Noelken ME, Hudson BG. Physical properties of collagen--sodium dodecyl sulfate complexes. Biochemistry. 1979 Oct 10/16/1979; 18(21): 4761-8. PMID: 497168, ISSN: 0006-2960.

Strickland DK, Hamilton JW, Hudson BG. Structure of the tryptic glycopeptide isolated from rabbit transferrin. Biochemistry. 1979 Jun 6/12/1979; 18(12): 2549-54. PMID: 444474, ISSN: 0006-2960.

Freytag JW, Dalrymple PN, Maguire MH, Strickland DK, Carraway KL, Hudson BG. Glomerular basement membrane. Studies on its structure and interaction with platelets. J. Biol. Chem. 1978 Dec 12/25/1978; 253(24): 9069-74. PMID: 721830, ISSN: 0021-9258.

Strickland DK, Hudson BG. Structural studies on rabbit transferrin: isolation and characterization of the glycopeptides. Biochemistry. 1978 Aug 8/8/1978; 17(16): 3411-8. PMID: 687592, ISSN: 0006-2960.

Freytag JW, Ohno M, Hudson BG. Large scale preparation of bovine renal glomerular basement membrane in the presence of protease inhibitors. Prep. Biochem. 1978; 8(2-3): 215-24. PMID: 568787, DOI: 10.1080/00327487808069061, ISSN: 0032-7484.

Tsao D, Colton DG, Chang JS, Buck RL, Hudson BG, Carraway KL. Alterations of red cell membranes from phenylhydrazine-treated rabbits. Biochim. Biophys. Acta. 1977 Aug 8/15/1977; 469(1): 61-73. PMID: 889825, ISSN: 0006-3002.

Peczon BD, Wegener LJ, Hung CH, Hudson BG. Intestinal basement membrane of Ascaris suum. Characterization of carbohydrate units. J. Biol. Chem. 1977 Jun 6/10/1977; 252(11): 4002-6. PMID: 863912, ISSN: 0021-9258.

Hung CH, Ohno M, Freytag JW, Hudson BG. Intestinal basement membrane of Ascaris suum. Analysis of polypeptide components. J. Biol. Chem. 1977 Jun 6/10/1977; 252(11): 3995-4001. PMID: 863911, ISSN: 0021-9258.

Hung CH, Strickland DK, Hudson BG. Estimation of molecular weights of peptides and glycopeptides by thin-layer gel filtration. Anal. Biochem. 1977 May 5/15/1977; 80(1): 91-100. PMID: 883648, PII: 0003-2697(77)90628-5, ISSN: 0003-2697.

Brown RC, Fish WW, Hudson BG, Ebner KE. Isolation and characterization of rat alpha-lactalbumin: a glycoprotein. Biochim. Biophys. Acta. 1977 Mar 3/28/1977; 491(1): 82-92. PMID: 849470, ISSN: 0006-3002.

Freytag JW, Ohno M, Hudson BG. Bovine renal glomerular basement membrane. Assessment of proteolysis during isolation. Biochem. Biophys. Res. Commun. 1976 Oct 10/4/1976; 72(3): 796-802. PMID: 985518, ISSN: 0006-291X.

Oho M, Riquetti P, Hudson BG. Bovine renal glomerular basement membrane. Isolation and characterization of a glycoprotein component. J. Biol. Chem. 1975 Oct 10/10/1975; 250(19): 7780-7. PMID: 1176447, ISSN: 0021-9258.

Lehman ED, Hudson BG, Ebner KE. Studies on the carbohydrate structure of bovine milk galactosyltransferase. FEBS Lett. 1975 Jun 6/1/1975; 54(1): 65-9. PMID: 805714, PII: 0014-5793(75)81069-6, ISSN: 0014-5793.

Hudson BG, Wegener LJ, Wingate JM, Carraway KL. Chemical studies of erythrocyte membrane glycoproteins from several species. Comp. Biochem. Physiol., B. 1975 May 5/15/1975; 51(1): 127-35. PMID: 1139875, ISSN: 0305-0491.

Shin BC, Ebner KE, Hudson BG, Carraway KL. Membrane glycoprotein differences between normal lactating mammary tissue and the R3230 AC mammary tumor. Cancer Res. 1975 May; 35(5): 1135-40. PMID: 123479, ISSN: 0008-5472.

Hudson BG, Heldebrant CM, Mann KG. Distribution of prothrombin carbohydrate units upon thrombin activation. Thromb. Res. 1975 Mar; 6(3): 215-21. PMID: 1114489, PII: 0049-3848(75)90069-9, ISSN: 0049-3848.

Guire P, Riquetti P, Hudson BG. An accelerated single column procedure for the programmed analysis of naturally-occuring amino acids of collagen and basement membrane. J. Chromatogr. 1974 Apr 4/10/1974; 90(2): 350-3. PMID: 4833161.

Odell V, Wegener L, Peczon B, Hudson BG. A rapid automatic analysis of hydroxylysine, hydroxylysine glycosides, and methionine sulfoxide in collagen and basement membrane. J. Chromatogr. 1974 Jan 1/30/1974; 88(2): 245-52. PMID: 4814348.

Hudson BG, Ono M, Brockway WJ, Castellino FJ. Chemical and physical properties of serum transferrins from several species. Biochemistry. 1973 Mar 3/13/1973; 12(6): 1047-53. PMID: 4734658, ISSN: 0006-2960.

Lehman ED, Hudson BG, Ebner KE. Micro-chromatographic and radiochemical analysis of glycopeptides. J. Chromatogr. 1973 Feb 2/28/1973; 76(2): 345-50. PMID: 4689608.

Hudson BG, McKenzie L, Ebner KE. Enzymic synthesis of lactose- 14 C (galactosyl- 14 C) and lactose- 3 H (glucosyl- 3 H). Anal. Biochem. 1972 Aug; 48(2): 524-8. PMID: 4672221, PII: 0003-2697(72)90107-8, ISSN: 0003-2697.

Hudson BG, Spiro RG. Fractionation of glycoprotein components of the reduced alkylated renal glomerular basement membrane. J. Biol. Chem. 1972 Jul 7/10/1972; 247(13): 4239-47. PMID: 5064342, ISSN: 0021-9258.

Hudson BG, Spiro RG. Studies on the native and reduced alkylated renal glomerular basement membrane. Solubility, subunit size, and reaction with cyanogen bromide. J. Biol. Chem. 1972 Jul 7/10/1972; 247(13): 4229-38. PMID: 5035690, ISSN: 0021-9258.

Zipilivan EM, Hudson BG, Blatt WF. Separation of immunologically active fragments by membrane partition chromatography. Anal. Biochem. 1969 Jul; 30(1): 91-8. PMID: 4978648, PII: 0003-2697(69)90376-5, ISSN: 0003-2697.

Blatt WF, Hudson BG. Removal of low molecular weight contaminants from 131-I-labeled insulin by selective ultrafiltration. Anal. Biochem. 1968 Nov; 26(2): 329-33. PMID: 5758048, PII: 0003-2697(68)90346-1, ISSN: 0003-2697.

Blatt WF, Hudson BG, Robinson SM, Zipilivan EM. A modified ultrafiltration cell for separating the products of proteolysis. Anal. Biochem. 1968 Jan; 22(1): 161-5. PMID: 5636947, PII: 0003-2697(68)90270-4, ISSN: 0003-2697.

Blatt WF, Hudson BG, Robinson SM, Zipilivan EM. Fractionation of protein solutions by membrane partition chromatography. Nature. 1967 Nov 11/4/1967; 216(5114): 511-3. PMID: 6057272, ISSN: 0028-0836.

Hudson BG, Barker R. The overoxidation of carbohydrates with sodium metaperiodate. J. Org. Chem. 1967 Jul; 32(7): 2101-9. PMID: 4292590, ISSN: 0022-3263.

Available Postdoctoral Position Details
Posted: 9/29/2014
The successful candidate for this beginning Postdoc position will work with High School Students and Undergraduates in conjunction with the Aspirnaut Program, under the Direction of Dr. Billy Hudson in the Division of Nephrology and Hypertension . The ability to translate research science to K-12 education programs will be essential in this position. Vanderbilt Experience and educator/training experience is preferred as well as a Ph.D.
More information relating to the Aspirnaut Program, please visit the website .

All interested Postdocs should apply via e-mail with a cover letter, current CV and minimum of 3 references to:
* Please put in subject line of e-mail : Aspirnaut PostDoc