Igor A. Feoktistov, Ph.D., C.Sc.

Associate Professor

igor.feoktistov@vanderbilt.edu

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Faculty Appointments
Associate Professor of Medicine Associate Professor of Pharmacology
Education
C.Sc., Molecular Biology, Tomsk Medical Institute, Tomsk, RussiaPh.D., Biochemistry, Tomsk Medical Institute, Tomsk, Russia
Office Address
360 PRB
2220 Pierce Ave
Nashville, TN 37232-6300
Research Description
The focus of the Feoktistov laboratory is to study the role of adenosine in physiological processes and disease states. Research interests center on two general areas: the protective role of adenosine in ischemic tissues and its potential for cardiac revascularization and regeneration using progenitor cells; and the role of adenosine in chronic lung diseases such as asthma.

Adenosine is generated in response to tissue hypoxia, cell stress or damage and exerts effects in essentially every organ system by interacting with four G protein-coupled receptors designated A1, A2A, A2B, and A3. A central hypothesis of our laboratory is that in pathophysiological situations associated with tissue hypoxia, when local levels of extracellular adenosine are considerably increased, A2B receptors become an integral part of a feedback mechanism aimed to restore oxygen supply to the affected tissues. Once activated, these receptors contribute to hypoxia-induced neovascularization by inducing synthesis of angiogenic factors molecules.

Although adenosine acts in most cases as a protective metabolite in various tissues, it serves as amplifier of lung inflammation and damage. Adenosine triggers asthma in asthmatic patients but not in normals, and blockade of adenosine receptors appears to be the mechanisms of action of theophylline and other xanthines. Our research is also aimed at identifying the specific receptor type that mediates adenosine actions in asthmatics. It is hoped that this research will lead to the development of more potent and specific anti-asthmatic drugs with lesser side effects than theophylline.
Research Keywords
Purinergic signaling in cardiovascular/pulmonary physiology and disease.
Publications
Novitskaya T, Chepurko E, Covarrubias R, Novitskiy S, Ryzhov SV, Feoktistov I, Gumina RJ. Extracellular nucleotide regulation and signaling in cardiac fibrosis. J. Mol. Cell. Cardiol [print-electronic]. 2016 Apr; 93: 47-56. PMID: 26891859, PII: S0022-2828(16)30039-6, DOI: 10.1016/j.yjmcc.2016.02.010, ISSN: 1095-8584.

Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis. Circ. Res [print-electronic]. 2015 Oct 10/9/2015; 117(9): 804-16. PMID: 26338900, PMCID: PMC4600464, PII: CIRCRESAHA.115.306886, DOI: 10.1161/CIRCRESAHA.115.306886, ISSN: 1524-4571.

Yuryeva K, Saltykova I, Ogorodova L, Kirillova N, Kulikov E, Korotkaya E, Iakovleva Y, Feoktistov I, Sazonov A, Ryzhov S. Expression of adenosine receptors in monocytes from patients with bronchial asthma. Biochem. Biophys. Res. Commun [print-electronic]. 2015 Sep 9/4/2015; 464(4): 1314-20. PMID: 26232643, PMCID: PMC4558207, PII: S0006-291X(15)30372-7, DOI: 10.1016/j.bbrc.2015.07.141, ISSN: 1090-2104.

Galindo CL, Kasasbeh E, Murphy A, Ryzhov S, Lenihan S, Ahmad FA, Williams P, Nunnally A, Adcock J, Song Y, Harrell FE, Tran TL, Parry TJ, Iaci J, Ganguly A, Feoktistov I, Stephenson MK, Caggiano AO, Sawyer DB, Cleator JH. Anti-remodeling and anti-fibrotic effects of the neuregulin-1ß glial growth factor 2 in a large animal model of heart failure. J Am Heart Assoc. 2014 Oct; 3(5): e000773. PMID: 25341890, PMCID: PMC4323814, PII: jah3718, DOI: 10.1161/JAHA.113.000773, ISSN: 2047-9980.

Ryzhov SV, Pickup MW, Chytil A, Gorska AE, Zhang Q, Owens P, Feoktistov I, Moses HL, Novitskiy SV. Role of TGF-ß signaling in generation of CD39+CD73+ myeloid cells in tumors. J. Immunol [print-electronic]. 2014 Sep 9/15/2014; 193(6): 3155-64. PMID: 25127858, PMCID: PMC4157098, PII: jimmunol.1400578, DOI: 10.4049/jimmunol.1400578, ISSN: 1550-6606.

Ryzhov S, Sung BH, Zhang Q, Weaver A, Gumina RJ, Biaggioni I, Feoktistov I. Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation. Purinergic Signal [print-electronic]. 2014 Sep; 10(3): 477-86. PMID: 24584483, PMCID: PMC4152448, DOI: 10.1007/s11302-014-9410-y, ISSN: 1573-9546.

Escudero C, Roberts JM, Myatt L, Feoktistov I. Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming. Front Pharmacol. 2014; 5: 134. PMID: 24926270, PMCID: PMC4046493, DOI: 10.3389/fphar.2014.00134, ISSN: 1663-9812.

Ryzhov S, Biktasova A, Goldstein AE, Zhang Q, Biaggioni I, Dikov MM, Feoktistov I. Role of JunB in adenosine A2B receptor-mediated vascular endothelial growth factor production. Mol. Pharmacol [print-electronic]. 2014 Jan; 85(1): 62-73. PMID: 24136993, PMCID: PMC3868903, PII: mol.113.088567, DOI: 10.1124/mol.113.088567, ISSN: 1521-0111.

Ryzhov S, Zhang Q, Biaggioni I, Feoktistov I. Adenosine A2B receptors on cardiac stem cell antigen (Sca)-1-positive stromal cells play a protective role in myocardial infarction. Am. J. Pathol [print-electronic]. 2013 Sep; 183(3): 665-72. PMID: 23827818, PMCID: PMC3763763, PII: S0002-9440(13)00398-2, DOI: 10.1016/j.ajpath.2013.05.012, ISSN: 1525-2191.

Ryzhov S, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I. Role of A2B adenosine receptors in regulation of paracrine functions of stem cell antigen 1-positive cardiac stromal cells. J. Pharmacol. Exp. Ther [print-electronic]. 2012 Jun; 341(3): 764-74. PMID: 22431204, PMCID: PMC3362889, PII: jpet.111.190835, DOI: 10.1124/jpet.111.190835, ISSN: 1521-0103.

Ryzhov S, Novitskiy SV, Goldstein AE, Biktasova A, Blackburn MR, Biaggioni I, Dikov MM, Feoktistov I. Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells. J. Immunol [print-electronic]. 2011 Dec 12/1/2011; 187(11): 6120-9. PMID: 22039302, PMCID: PMC3221925, PII: jimmunol.1101225, DOI: 10.4049/jimmunol.1101225, ISSN: 1550-6606.

Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Dis Model Mech [print-electronic]. 2011 Jul; 4(4): 469-83. PMID: 21324930, PMCID: PMC3124051, PII: dmm.006510, DOI: 10.1242/dmm.006510, ISSN: 1754-8411.

Feoktistov I, Biaggioni I. Role of adenosine A(2B) receptors in inflammation. Adv. Pharmacol. 2011; 61: 115-44. PMID: 21586358, PMCID: PMC3748596, PII: B978-0-12-385526-8.00005-9, DOI: 10.1016/B978-0-12-385526-8.00005-9, ISSN: 1557-8925.

Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS, Biaggioni I, Feoktistov I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2010 May; 42(5): 564-71. PMID: 19556606, PMCID: PMC2874442, PII: 2008-0391OC, DOI: 10.1165/rcmb.2008-0391OC, ISSN: 1535-4989.

Ryzhov S, Zaynagetdinov R, Goldstein AE, Matafonov A, Biaggioni I, Feoktistov I. Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8. Purinergic Signal [print-electronic]. 2009 Sep; 5(3): 289-98. PMID: 19125355, PMCID: PMC2717310, DOI: 10.1007/s11302-008-9129-8, ISSN: 1573-9538.

Feoktistov, I, Biaggioni, I, Cronstein, BN. Handb Exp Pharmacol. [place unknown: publisher unknown]; 2009. Available from: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19639289&dopt=Abstract.

Feoktistov I, Biaggioni I, Cronstein BN. Adenosine receptors in wound healing, fibrosis and angiogenesis. Handb Exp Pharmacol. 2009; (193): 383-97. PMID: 19639289, PMCID: PMC3729032, DOI: 10.1007/978-3-540-89615-9_13, ISSN: 0171-2004.

Ryzhov S, Novitskiy SV, Zaynagetdinov R, Goldstein AE, Carbone DP, Biaggioni I, Dikov MM, Feoktistov I. Host A(2B) adenosine receptors promote carcinoma growth. Neoplasia. 2008 Sep; 10(9): 987-95. PMID: 18714400, PMCID: PMC2517644, ISSN: 1476-5586.

Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood [print-electronic]. 2008 Sep 9/1/2008; 112(5): 1822-31. PMID: 18559975, PMCID: PMC2518889, PII: blood-2008-02-136325, DOI: 10.1182/blood-2008-02-136325, ISSN: 1528-0020.

Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells. J. Immunol. 2008 Jun 6/1/2008; 180(11): 7212-20. PMID: 18490720, PMCID: PMC3628765, PII: 180/11/7212, ISSN: 0022-1767.

Ryzhov S, Solenkova NV, Goldstein AE, Lamparter M, Fleenor T, Young PP, Greelish JP, Byrne JG, Vaughan DE, Biaggioni I, Hatzopoulos AK, Feoktistov I. Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Circ. Res [print-electronic]. 2008 Feb 2/15/2008; 102(3): 356-63. PMID: 18032734, PMCID: PMC2803108, PII: CIRCRESAHA.107.158147, DOI: 10.1161/CIRCRESAHA.107.158147, ISSN: 1524-4571.

Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Blackburn MR, Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines. J. Pharmacol. Exp. Ther [print-electronic]. 2008 Feb; 324(2): 694-700. PMID: 17965229, PII: jpet.107.131540, DOI: 10.1124/jpet.107.131540, ISSN: 1521-0103.

Ryzhov S, Zaynagetdinov R., Goldstein A.E., Biaggioni I, Feoktistov I. Effect of genetic A2B adenosine receptor ablation on pro-inflammatory actions of adenosine in mast cells. FASEB J. 2008; 22: 1075.7.

Ryzhov S., Novitsky S.V, Zaynagetdinov R., Goldstein A.E, Biaggioni I., Carbone D.P., Feoktistov I., Dikov M.M. Adenosine receptors in regulation of dendritic cell differentiation and function. FASEB J. 2008; 22: 1065.34.

Ryzhov S., Novitsky S.V, Zaynagetdinov R., Goldstein A.E, Biaggioni I., Dikov M.M., Feoktistov I. A2B adenosine receptors promote tumor growth. FASEB J. 2008; 22: 898.16.

Ryzhov S., Novitskiy S.V., Zaynagetdinov R., Goldstein A., Biaggioni I., Carbone D.C., Dikov M.M., Feoktistov I. Adenosine A2B receptors on host immune cells promote carcinoma growth. Purinergic Signal. 2008; 4: 68.

Ryzhov S, Zaynagetdinov R., Goldstein A.E., Novitskiy S.V. Blackburn M.R., Biaggioni I, Feoktistov I. Effect of A2B adenosine receptor gene ablation on pro-inflammatory actions of adenosine in mast cells. Purinergic Signal. 2008; 4: 158-9.

Ryzhov S, McCaleb JL, Goldstein AE, Biaggioni I, Feoktistov I. Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia. J. Pharmacol. Exp. Ther [print-electronic]. 2007 Feb; 320(2): 565-72. PMID: 17132813, PII: jpet.106.114850, DOI: 10.1124/jpet.106.114850, ISSN: 0022-3565.

Ryzhov S., Zaynagetdinov R., Goldstein A E, Feoktistov I, Biaggioni I. Pro-inflammatory effects of native A2B adenosine receptors. Hypertension. 2007; 50: E144.

Ryzhov S., McCaleb J.L., Goldstein A.E., Zaynagetdinov R., Biaggioni I., Feoktistov I. Pro-angiogenic role of adenosine receptors in hypoxia. FASEB J. 2007; 21: A1162.

Ryzhov S, Goldstein AE, Biaggioni I, Feoktistov I. Cross-talk between G(s)- and G(q)-coupled pathways in regulation of interleukin-4 by A(2B) adenosine receptors in human mast cells. Mol. Pharmacol [print-electronic]. 2006 Aug; 70(2): 727-35. PMID: 16707627, PII: mol.106.022780, DOI: 10.1124/mol.106.022780, ISSN: 0026-895X.

Ryzhov S., Goldstein AE., Biaggioni I., Feoktistov I. Cross-talk between Gs and Gq coupled pathways in regulation of IL-4 by A2B adenosine receptors in human mast cells. FASEB J. 2006; 20: A249.

Feoktistov I., Biaggioni I. Role of adenosine receptors in regulation of pro- inflammatory and proangiogenic cytokines in mast cells. Purinergic Signal. 2006; 2: 34-5.

Ryzhov S., Goldstein AE., Biaggioni I., Feoktistov I. Cooperation between Gq and Gs-linked signaling pathways in regulation of IL-4 by adenosine in mast cells. Purinergic Signal. 2006; 2: 161.

Ryzhov S, Goldstein A, Biaggioni I, Feoktistov I. Hypoxia and adenosine differentially express angiogenic factors in human microvascular endothelial cells. Arterioscler Thromb Vasc Biol. 2005; 25((5)): E104.

Ryzhov S, Biaggioni I, Feoktistov I. Role of the A2B adenosine receptor carboxyl terminus in regulation of cAMP and IL-8. FASEB J. 2005; 19((5)): A1104.

Feoktistov I. Role of adenosine in angiogenesis. Bulletin of Siberian Medicine. 2005; 4((Suppl 1)): 48.

Ryzhov S, Matafonov A, Goldstein A, Biaggioni I, Feoktistov I. Low and high molecular forms of adenosine A2B receptors are responsible for differential coupling to intracellular pathways. Hypertension. 2005; 46((4)): 840.

Ryzhov S, Matafonov A, Goldstein A, Biaggioni I, Feoktistov I. Low and high molecular forms of adenosine A2B receptors are responsible for differential coupling to intracellular pathways. Hypertension. 2005; 46((4)): 840.

Biaggioni I, Feoktistov I. Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Deaseases. [place unknown: publisher unknown]; 2005.

Feoktistov I, Ryzhov S, Zhong H, Goldstein AE, Matafonov A, Zeng D, Biaggioni I. Hypoxia modulates adenosine receptors in human endothelial and smooth muscle cells toward an A2B angiogenic phenotype. Hypertension [print-electronic]. 2004 Nov; 44(5): 649-54. PMID: 15452028, PII: 01.HYP.0000144800.21037.a5, DOI: 10.1161/01.HYP.0000144800.21037.a5, ISSN: 1524-4563.

Ryzhov S, Goldstein AE, Matafonov A, Zeng D, Biaggioni I, Feoktistov I. Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J. Immunol. 2004 Jun 6/15/2004; 172(12): 7726-33. PMID: 15187156, PII: 172/12/7726, ISSN: 0022-1767.

Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD. Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation. Mol. Pharmacol. 2004 Jun; 65(6): 1462-74. PMID: 15155839, PII: 65/6/1462, DOI: 10.1124/mol.65.6.1462, ISSN: 0026-895X.

Zhong H, Belardinelli L, Maa T, Feoktistov I, Biaggioni I, Zeng D. A(2B) adenosine receptors increase cytokine release by bronchial smooth muscle cells. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2004 Jan; 30(1): 118-25. PMID: 12855406, PII: 2003-0118OC, DOI: 10.1165/rcmb.2003-0118OC, ISSN: 1044-1549.

Ryzhov S, Goldstein AE, Matafonov A, Feoktistov I, Biaggioni I. Coupling of adenosine A2B receptors to Gq-PLC signaling pathway is associated with low density membrane fractions. FASEB J. 2004; 18((4)): A585.

Zhu CB, Hewlett WA, Biaggioni I, Feoktistov I, Blakely RD. Signaling pathways supporting adenosine receptor-mediated 5-HT transport: trafficking dependent and independent modes. FASEB J. 2004; 18((4)): A207.

Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. Circ. Res [print-electronic]. 2003 Mar 3/21/2003; 92(5): 485-92. PMID: 12600879, PII: 01.RES.0000061572.10929.2D, DOI: 10.1161/01.RES.0000061572.10929.2D, ISSN: 1524-4571.

Feoktistov I., Ryzhov S., Goldstein A.E., Matafonov A., Maa T., Zeng D., Belardinelli L., Biaggioni I. Modulation of Adenosine A2A Receptor Function by A2B Receptors. Hypertension. 2003; 42((3)): 391.

Feoktistov I., Ryzhov S., Goldstein A.E., Biaggioni I. Cooperative Interactions Between A2B and A3 Adenosine Receptors in Mast Cell-mediated Angiogenesis. FASEB J. 2003; 17: A1054.

Ryzhov S, Goldstein A, Matafonov A, Feoktistov I, Biaggioni I. Hypoxia modulates adenosine receptor expression in human endothelial cells towards an A2B phenotype. Circulation. 2003; 108((17)): 19.

Bshesh K, Zhao B, Spight D, Biaggioni I, Feokistov I, Denenberg A, Wong HR, Shanley TP. The A2A receptor mediates an endogenous regulatory pathway of cytokine expression in THP-1 cells. J. Leukoc. Biol. 2002 Nov; 72(5): 1027-36. PMID: 12429726, ISSN: 0741-5400.

Feoktistov I, Goldstein AE, Ryzhov S, Zeng D, Belardinelli L, Voyno-Yasenetskaya T, Biaggioni I. Differential expression of adenosine receptors in human endothelial cells: role of A2B receptors in angiogenic factor regulation. Circ. Res. 2002 Mar 3/22/2002; 90(5): 531-8. PMID: 11909816, ISSN: 1524-4571.

Ryzhov S., Goldstein AE., Feoktistov I., Biaggioni I. Heteromeric association of A2A and A2B adenosine receptors. FASEB J. 2002; 16: A196.

Feoktistov I., Ryzhov S., Goldstein AE., Biaggioni I. Role of adenosine receptor subtypes in generation of pro-angiogenic factors. FASEB J. 2002; 16: A933.

Feoktistov I., Goldstein A.E., Ryzhov S., Zeng D., Belardinelli L., Voyno-Yasenetskaya, T., Biaggioni I. Differential expression of adenosine receptors in human endothelial cells. Role of adenosine A2B receptors in angiogenic factor regulation. Arterioscl Throm Vas Biol. 2002; 22: 397.

Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I. Potential role of mast cells on adenosine-induced angiogenesis; Stimulation of VEGF, IL-8 and angiopoietin-2 expression. Hypertension. 2002; 40((3)): 402.

Feoktistov I., Ryzhov S., Goldstein AE., Biaggioni I. Heteromeric association of A2A and A2B adenosine receptors. Drug Dev Res. 2002; 56: 574.

Feoktistov I., Ryzhov S., Goldstein AE., Biaggioni I. Human mast cells HMC-1 express A2A, A2B and A3 mRNA; Functional relevance and modulation by dexamethasone. Drug Dev Res. 2002; 56: 575.

Feoktistov I., Ryzhov S., Goldstein A.E., Biaggioni I. Synergistic expression of angiogenic factors IL-8, VEGF and angiopoietin-2 by A2B and A3 adenosine receptors in human mast cells. Circulation. 2002; 106((19)): 1080.

Feoktistov I, Garland EM, Goldstein AE, Zeng D, Belardinelli L, Wells JN, Biaggioni I. Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Biochem. Pharmacol. 2001 Nov 11/1/2001; 62(9): 1163-73. PMID: 11705449, PII: S0006295201007651, ISSN: 0006-2952.

Grant MB, Davis MI, Caballero S, Feoktistov I, Biaggioni I, Belardinelli L. Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Invest. Ophthalmol. Vis. Sci. 2001 Aug; 42(9): 2068-73. PMID: 11481274, ISSN: 0146-0404.

Feoktistov I., Goldstein AE., Biaggioni I. Regulation of VEGF expression by adenosine: Role of G proteins. FASEB J. 2001; 15: A580.

Feoktistov I, Goldstein AE, Biaggioni I. Adenosine A2B receptors regulate expression of heat shock protein 90 (Hsp90) in endothelial cells. Hypertension. 2001; 38: 18.

Biaggioni I, Feoktistov I. Handb Exp Pharmacol. [place unknown: publisher unknown]; 2001. (151).

Feoktistov I, Goldstein AE, Biaggioni I. Cyclic AMP and protein kinase A stimulate Cdc42: role of A(2) adenosine receptors in human mast cells. Mol. Pharmacol. 2000 Nov; 58(5): 903-10. PMID: 11040036, ISSN: 0026-895X.

Olanrewaju HA, Qin W, Feoktistov I, Scemama JL, Mustafa SJ. Adenosine A(2A) and A(2B) receptors in cultured human and porcine coronary artery endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 2000 Aug; 279(2): H650-6. PMID: 10924064, ISSN: 0363-6135.

Olanrewaju HA, Qin W, Feoktistov I, Scemama JL, Mustafa SJ. A2B adenosine receptor in cultured human and porcine coronary artery endothelial cells. FASEB J. 2000; 14: A162.

Feoktistov I, Goldstein AE, Voyno-Yasenetskaya TA, Biaggioni I. Cooperation between G-proteins in regulation of IL-8 gene expression. FASEB J. 2000; 14: A1344.

Feoktistov I, Goldstein AE, Biaggioni I. Role of cyclic AMP in stimulation of Cdc42 by adenosine A2A and A2B adenosine receptors in human mast cells. FASEB J. 2000; 14: A1497.

Feoktistov I, Goldstein AE, Biaggioni I. A2A and A2B adenosine receptors stimulate Cdc42 in human mast cells. Drug Dev Res. 2000; 50: 83.

Feoktistov I, Goldstein AE, Voyno-Yasenetskaya TA, Biaggioni I. Cooperation between G-proteins in regulation of IL-8 gene expression. Drug Dev Res. 2000; 50: 83.

Biaggioni I, Feoktistov I, Sheller JR, Grant MB, Belardinelli L, Wells JN. Development of new selective A2B antagonists with greater potency than enprofylline. Drug Dev Res. 2000; 50: 104.

Grant MB, Tarnuzzer RW, Caballero S, Ozeck MJ, Davis MI, Spoerri PE, Feoktistov I, Biaggioni I, Shryock JC, Belardinelli L. Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells. Circ. Res. 1999 Oct 10/15/1999; 85(8): 699-706. PMID: 10521243, ISSN: 1524-4571.

Feoktistov I, Goldstein AE, Biaggioni I. Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. Mol. Pharmacol. 1999 Apr; 55(4): 726-34. PMID: 10101031, ISSN: 0026-895X.

Audoly LP, Ma L, Feoktistov I, de Foe SK, Breyer MD, Breyer RM. Prostaglandin E-prostanoid-3 receptor activation of cyclic AMP response element-mediated gene transcription. J. Pharmacol. Exp. Ther. 1999 Apr; 289(1): 140-8. PMID: 10086997, ISSN: 0022-3565.

Feoktistov I, Goldstein AE, Biaggioni I. Role of p38 MAPK and ERK signaling pathways in adenosine A2B receptor-dependent stimulation of IL-8 production in human mast cells. FASEB J. 1999; 13: A1401.

Feoktistov I, Goldstein AE, Biaggioni I. Role of extracellular signal-regulated kinase (ERK) in the activation of Ras by adenosine A2B receptors and protein kinase C. Circulation. 1999; 100.

Feoktistov I, Polosa R, Holgate ST, Biaggioni I. Adenosine A2B receptors: a novel therapeutic target in asthma?. Trends Pharmacol. Sci. 1998 Apr; 19(4): 148-53. PMID: 9612090, PII: S0165-6147(98)01179-1, ISSN: 0165-6147.

Feoktistov I, Biaggioni I. Pharmacological characterization of adenosine A2B receptors: studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes. Biochem. Pharmacol. 1998 Mar 3/1/1998; 55(5): 627-33. PMID: 9515573, PII: S0006-2952(97)00512-1, ISSN: 0006-2952.

37. Feoktistov I, Goldstein AE, Biaggioni I. Adenosine A2a receptors are essential for A2b receptor-dependent stimulation of MAPK and IL-8 secretion in human mast cells. FASEB J. 1998; 12: A1454.

Feoktistov I, Goldstein AE, Biaggioni I. A2b receptors stimulate MAP kinase in human mast cell. Drug Dev Res. 1998; 43: 10.

Feoktistov I, Goldstein AE, Biaggioni I. A2a receptors are essential for A2b function. Drug Dev Res. 1998; 43: 11.

Feoktistov I, Nastanski F, Hoover R, Biaggioni I. Adenosine A2a and a2b receptors are expressed in human endothelial cells. Drug Dev Res. 1998; 43: 44.

Feoktistov I, Biaggioni I. Adenosine A2B receptors. Pharmacol. Rev. 1997 Dec; 49(4): 381-402. PMID: 9443164, ISSN: 0031-6997.

Feoktistov I, Breyer RM, Biaggioni I. Prostanoid receptor with a novel pharmacological profile in human erythroleukemia cells. Biochem. Pharmacol. 1997 Oct 10/15/1997; 54(8): 917-26. PMID: 9354592, PII: S0006-2952(97)00288-8, ISSN: 0006-2952.

Feoktistov I, Biaggioni I. Role of adenosine in asthma. Drug Dev. Res. 1996; 39: 333-6. PMID: 11542498, DOI: 10.1002/(SICI)1098-2299(199611/12)39:3/4<333::AID-DDR14>3.0.CO;2-2, ISSN: 0272-4391.

Feoktistov I, Sheller JR, Biaggioni I. Adenosine A2b receptors as targets for antiasthmatic methylxanthines. FASEB J. 1996; 10: A1232.

Feoktistov I, Vallejo V, Biaggioni I. Adenosine A2b receptors: G-protein coupling and calcium signaling. Drug Dev Res. 1996; 37: 121.

Feoktistov I, Sheller JR, Vallejo V, Biaggioni I. Immunological identification of adenosine A2b receptors in human lung mast cells. Drug Dev Res. 1996; 37: 146.

Feoktistov I, Biaggioni I. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J. Clin. Invest. 1995 Oct; 96(4): 1979-86. PMID: 7560091, PMCID: PMC185836, DOI: 10.1172/JCI118245, ISSN: 0021-9738.

Feoktistov I, Biaggioni I, editor.. Positive coupling of adenosine A2b receptors to intracellular calcium involves different pathways.

Feoktistov I, Biaggioni I. Adenosine A2b receptors activate interleukin-8 (IL-8) production in human mast cells. FASEB J. 1995; 7: A1381.

Feoktistov I, Murray JJ, Biaggioni I. Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells. Mol. Pharmacol. 1994 Jun; 45(6): 1160-7. PMID: 8022409, ISSN: 0026-895X.

Feoktistov I, Biaggioni I. Adenosine A2b receptors positively modulate cytoplasmic Ca2+ in human erythroleukemia cells through a cholera toxin-sensitive mechanism. Clin Res. 1994; 42((2)): 332A.

Feoktistov I, Biaggioni I. Prostacyclin and PGE1 receptors increase cyoplasmic Ca2+ in human erythroleukemia cells through distinct G-proteins. Clin Res. 1994; 42((2)): 332A.

Feoktistov I, Biaggioni I. Characterization of adenosine receptors in human erythroleukemia cells and platelets: further evidence for heterogeneity of adenosine A2 receptor subtypes. Mol. Pharmacol. 1993 Jun; 43(6): 909-14. PMID: 8391117, ISSN: 0026-895X.

Feoktistov IA, Paul S, Hollister AS, Robertson D, Biaggioni I. Role of cyclic AMP in adenosine inhibition of intracellular calcium rise in human platelets. Comparison of adenosine effects on thrombin- and epinephrine-induced platelet stimulation. Am. J. Hypertens. 1992 Jun; 5(6 Pt 2): 147S-153S. PMID: 1321639, ISSN: 0895-7061.

Feoktistov IA, Pol S, Khollister AS, Robertson D, Biadzhoni I. [Mechanism of action of adenosine on intracellular calcium and platelet aggregation]. Kardiologiia. 1991 Nov; 31(11): 76-9. PMID: 1666665, ISSN: 0022-9040.

Feoktistov IA, Vologushev SA, Karpov RS. [Effects of high-density lipoproteins on thrombin-induced platelet aggregation]. Biull Eksp Biol Med. 1991 May; 111(5): 485-6. PMID: 1878561, ISSN: 0365-9615.

Larionov NP, Afanasyev SA, Krylatov AV, Feoktistov IA, editor.. Effects of troponin C modulators on cardiac contractility.

Goldshtein AE, Shur SA, Feoktistov IA. [The effect of media pH and autocatalytic phosphorylation on the interaction of kinase phosphorylase with calmodulin]. Biokhimiia. 1990 Dec; 55(12): 2255-60. PMID: 2096954, ISSN: 0320-9725.

Feoktistov IA, Krylatov AV, Larionov NP. [The effect of calmodulin inhibitors and the new cardiotonic drug DPI 201-106 on the formation of interprotein bonds in the cardiac troponin complex]. Biokhimiia. 1990 Jul; 55(7): 1251-6. PMID: 2223899, ISSN: 0320-9725.

Paul S, Feoktistov I, Hollister AS, Robertson D, Biaggioni I. Adenosine inhibits the rise in intracellular calcium and platelet aggregation produced by thrombin: evidence that both effects are coupled to adenylate cyclase. Mol. Pharmacol. 1990 Jun; 37(6): 870-5. PMID: 2359405, ISSN: 0026-895X.

Feoktistov IA, Baldenkov GN, Barannik IV, Cherviakov EB, Larionov NP. [Interaction of calcium agonists and antagonists with Ca-binding proteins and their effect on cyclic nucleotide phosphodiesterase]. Biokhimiia. 1990 Apr; 55(4): 754-9. PMID: 2165822, ISSN: 0320-9725.

Krylatov AV, Feoktistov IA, Larionov NP, editor.. Effects of cardiotonic drugs on troponin C function.

Goldshtein AE, Feoktistov IA, Larionov NP, editor.. Calmodulin binding to phosphorylase kinase: Role of pH and autocatalytic phosphorylation.

Bochkov VN, Feoktistov IA, Avdonin PV, Tkachuk VA. [Phorbol ester blocks the coupling of GTP-binding protein with receptor-controlled calcium channels]. Biokhimiia. 1989 Sep; 54(9): 1533-42. PMID: 2556188, ISSN: 0320-9725.

Feoktistov IA, Krylatov AV, Zabeivorota SI, Cherviakov EB, Larionov NP. [Effect of calcium ions on the interaction of troponin C with rabbit skeletal muscle troponin I and troponin T immobilized on polyvinyl chloride]. Biokhimiia. 1989 Feb; 54(2): 265-72. PMID: 2742925, ISSN: 0320-9725.

Krylatov AV, Feoktistov IA, Larionov NP, editor.. Protein protein interactions in cardiac troponin: Effects of calmodulin inhibitors and DPI 201 106 on calcium dependent interaction of troponin C with troponin I.

Goldshtein AE, Shur SA, Feoktistov IA, Skolysheva LK, editor.. Fluorescence technique in study of calmodulin binding to phosphorylase kinase.

Feoktistov IA, Chervyakov EB, Larionov NP, Kovalev SG, Anisimova VA, editor.. Effects of condensed nitrogen containing heterocyclic compounds on calmodulin and cardiac phosphodiesterase.

Larionov NP, Feoktistov IA, Krylatov AV, Chervyakov EB, editor.. Molecular and cellular models in screening of pharmacological regulators of calcium metabolism.

Larionov NP, Laptev BI, Malyshev IYu, Feoktistov IA, editor.. Physiological regulation of Ca dependent processes in ischemia and reperfusion.

Larionov NP, Krylatov AV, Feoktistov IA. Interactions between components of cardiac and skeletal troponin complex. J Mol Cell Cardiol. 1989; 21((Suppl IV)).

Baldenkov G, Feoktistov I, Chervyakov E, Barannik I, Borisova Y. Interaction of calcium channel modulators with Ca-binding proteins. J Mol Cell Cardiol. 1989; 21((Suppl IV)).

Feoktistov IV, Paul S, Hollister AS, Robertson D, Biaggioni I. Mechanisms of adenosine inhibition of intracellular calcium rise in human platelets. Circulation. 1989; 80((Suppl II)).

Zoloev GK, Barannic IV, Lasukova TB, Feoktistov IA, editor.. Effect of calmodulin interacting drugs on experimental hypoxic hypoxia.

Krylatov AV, Feoktistov IA, Gusev NB, editor.. Interaction of phenothiazines with rabbit skeletal muscle troponin C: Effect of trifluoperazine on calcium binding properties of troponin C.

Krylatov AV, Feoktistov IA, editor.. Interaction of troponin C with cardiac and skeletal muscle troponin T and troponin I, immobilized on polyvinylchloride matrix.

Feoktistov IA, Chervyakov EB, Krylatov AV, Barannik IV, Baldenkov GN, Larionov NP, editor.. Effects of calcium entry agonists on calcium binding proteins.

Tkachuk VA, Baldenkov GN, Feoktistov IA, Men'shikov MY, Quast U, Herzig JW. Metofenazate as a more selective calmodulin inhibitor than trifluoperazine. Arzneimittelforschung. 1987 Sep; 37(9): 1013-7. PMID: 2449225, ISSN: 0004-4172.

Feoktistov IA, Baldenkov GN, Men'shikov MIu, Larionov NP. [The use of pharmacological preparations for the study of calmodulin interaction with enzymes]. Vopr. Med. Khim. 1987 Mar; 33(2): 27-31. PMID: 3037792, ISSN: 0042-8809.

Feoktistov IA, Baldenkov GN, Barannik IV, Krylatov AV, Chervyakov EB, Larionov NP, editor.. Effects of calcium entry blockers on calcium binding proteins.

Feoktistov IA, Larionov NP, Baldenkov GN, editor.. Effect of lipids on cardiac cyclic nucleotide phosphodiesterase.

Larionov NP, Feoktistov IA, Krylatov AV, Afanasyev S, Baskakov MB, editor.. Effects of ischemia and calmodulin inhibitors on the heart.

Larionov NP, Ivanov VV, Khavalkin IV, Feoktistov IA, editor.. Effects of phenothiazines on macrophage chemoluminescence.

Krylatov AV, Feoktistov IA, Zabeyvorota SI, Larionov NP, editor.. Interaction of rabbit skeletal muscle troponin components.

Herzig JW, Tkachuk VA, Baldenkov GN, Feoktistov IA, Men'shikov MYu, Quast U. Calmodulin and troponin C as targets for drug action. Biomed. Biochim. Acta. 1987; 46(8-9): S440-3. PMID: 2449186, ISSN: 0232-766X.

Feoktistov IA, Larionov NP. Calcium as a Regulator of Metabolism. [place unknown: publisher unknown]; 1987.

Larionov NP, Laptev BI, Afanasiev SA, Malyshev IIu, Feoktistov IA. [Effect of frenolone on the contractile function of papillary muscles]. Kardiologiia. 1986 Oct; 26(10): 101-3. PMID: 3795689, ISSN: 0022-9040.

Krylatov AV, Feoktistov IA, editor.. Effects of troponin I and troponin T on calmodulin and cyclic nucleotides phosphodiesterase.

Krylatov AV, Feoktistov IA, editor.. Effect of 3,3' dipropylthiocarbocyanine iodide on calmodulin and cyclic nucleotide phosphodiesterase.

Larionov NP, Feoktistov IA, Menshikov MYu, editor.. Ca dependent regulation of phosphorylase kinase B.

Feoktistov IA, Krylatov AV, Larionov NP, editor.. Effects of calmodulin inhibitors on Ca dependent regulation of phosphorylase kinase.

Larionov NP, Feoktistov IA, Krylatov AV, Kovalev IV, Baskakov MB, editor.. Mechanism of protective effects of calmodulin and troponin C inhibitors in ischemia.

Larionov NP, Feoktistov IA, Krylatov AV, Baldenkov GN, Menshikov MY, Ivanov VV, editor.. Pharmacological regulation of Ca-dependent processes.

Lishmanov YuB, Maslov LN, Maslova LV, Feoktistov IA, editor.. Effects of enkephalins on the degree of stressor and ischemic myocardial lesions.

Baldenkov GN, Avdonin PV, Menshikov MY, Feoktistov IA, Tkachuk VA. The Significance of Calcium Antagonists Today. [place unknown: publisher unknown]; 1986.

Baldenkov GN, Men'shikov MIu, Feoktistov IA, Tkachuk VA. [Effect of neurotropic drugs on calmodulin and troponin C-dependent processes]. Biokhimiia. 1985 Jul; 50(7): 1141-50. PMID: 2864085, ISSN: 0320-9725.

Feoktistov IA, Menshikov MYu. Current Problems of Cardiology, Oncology, and Psychiatry. [place unknown: publisher unknown]; 1985.

Prokopyeva VD, Roshepkin VZ, Barannik IV, Feoktistov IA, Larionov NP, editor.. Effects of phenothiazines on SR Ca ATPase.

Larionov NP, Afanasyev SA, Feoktistov IA. Homeostatic Processes in Isolated Systems and Organisms. [place unknown: publisher unknown]; 1983.

Larionov NP, Feoktistov IA. [Effect of calmodulin inhibitor trifluoperazine on calcium activation of phosphorylase in glycosomes of rabbit skeletal muscles]. Biull Eksp Biol Med. 1982 Sep; 94(9): 35-6. PMID: 7171821, ISSN: 0365-9615.

Feoktistov IA, editor.. Effects of trifluoperazine on Ca dependent activation of phosphorylase kynase.