Tao Yang, Ph.D.

Research Professor

tao.yang.2@vanderbilt.edu
Faculty Appointments
Research Professor of Medicine Research Professor of Pharmacology
Education
Ph.D., Physiology, China Three Gorges University Medical College, Yichang, ChinaM.S., Pharmacology, Hubei Medical University, Wuhan, ChinaB.S., Medicine, Hubei Medical University, Wuhan, China
Office Address
1275 MRB-4, Oates Institute, VUMC, TN 37232-0575
TN 37232-0575
Research Keywords
Cardiac electrophysiology, ion channel biology and drug actions
Publications
Stroud DM, Yang T, Bersell K, Kryshtal DO, Nagao S, Shaffer C, Short L, Hall L, Atack TC, Zhang W, Knollmann BC, Baudenbacher F, Roden DM. Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart. J Am Heart Assoc. 2016 Nov 11/2/2016; 5(11): PMID: 27806966, PII: JAHA.115.002946, DOI: 10.1161/JAHA.115.002946, ISSN: 2047-9980.

Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G. KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting. Nat Commun. 2016 Oct 10/12/2016; 7: 12795. PMID: 27731317, PMCID: PMC5064022, PII: ncomms12795, DOI: 10.1038/ncomms12795, ISSN: 2041-1723.

Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E, Prins BP, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, Ackerman MJ, Haunso S, Leenhardt A, Kääb S, Probst V, Redon R, Sharma S, Wilde A, Tfelt-Hansen J, Schwartz P, Roden DM, Bezzina CR, Olesen M, Darbar D, Guicheney P, Crotti L, , Jamshidi Y. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Cardiovasc. Res [print-electronic]. 2015 Jun 6/1/2015; 106(3): 520-9. PMID: 25691538, PMCID: PMC4447806, PII: cvv042, DOI: 10.1093/cvr/cvv042, ISSN: 1755-3245.

Williams VS, Cresswell CJ, Ruspi G, Yang T, Atak TC, McLoughlin M, Ingram CD, Ramirez AH, Roden D, Armstrong M. Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome. Europace [print-electronic]. 2015 Apr; 17(4): 635-41. PMID: 25564553, PII: euu288, DOI: 10.1093/europace/euu288, ISSN: 1532-2092.

Savio-Galimberti E, Weeke P, Muhammad R, Blair M, Ansari S, Short L, Atack TC, Kor K, Vanoye CG, Olesen MS, LuCamp, Yang T, George AL, Roden DM, Darbar D. SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation. Cardiovasc. Res [print-electronic]. 2014 Nov 11/1/2014; 104(2): 355-63. PMID: 25053638, PMCID: PMC4271018, PII: cvu170, DOI: 10.1093/cvr/cvu170, ISSN: 1755-3245.

Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM. Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current. Circulation [print-electronic]. 2014 Jul 7/15/2014; 130(3): 224-34. PMID: 24895457, PMCID: PMC4101031, PII: CIRCULATIONAHA.113.007765, DOI: 10.1161/CIRCULATIONAHA.113.007765, ISSN: 1524-4539.

Yang T, Smith JA, Leake BF, Sanders CR, Meiler J, Roden DM. An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1. Mol. Pharmacol [print-electronic]. 2013 Feb; 83(2): 481-9. PMID: 23193163, PMCID: PMC3558809, PII: mol.112.081513, DOI: 10.1124/mol.112.081513, ISSN: 1521-0111.

Lowe JS, Stroud DM, Yang T, Hall L, Atack TC, Roden DM. Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice. Cardiovasc. Res [print-electronic]. 2012 Aug 8/1/2012; 95(3): 300-7. PMID: 22562703, PMCID: PMC3633400, PII: cvs160, DOI: 10.1093/cvr/cvs160, ISSN: 1755-3245.

Lowe JS, Stroud DM, Yang T, Hall L, Atack TC, Roden DM. Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice. Cardiovasc. Res [print-electronic]. 2012 Aug 8/1/2012; 95(3): 300-7. PMID: 22562703, PMCID: PMC3633400, PII: cvs160, DOI: 10.1093/cvr/cvs160, ISSN: 1755-3245.

Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM. Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circ. Res [print-electronic]. 2012 Jul 7/20/2012; 111(3): 322-32. PMID: 22723299, PMCID: PMC3412150, PII: CIRCRESAHA.112.265173, DOI: 10.1161/CIRCRESAHA.112.265173, ISSN: 1524-4571.

Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Roden DM. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Circulation [print-electronic]. 2011 Aug 8/30/2011; 124(9): 1001-11. PMID: 21824921, PMCID: PMC3297976, PII: CIRCULATIONAHA.110.987248, DOI: 10.1161/CIRCULATIONAHA.110.987248, ISSN: 1524-4539.

Atack TC, Stroud DM, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM. Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel. Circ. Res [print-electronic]. 2011 Jun 6/24/2011; 109(1): 38-46. PMID: 21566215, PMCID: PMC3135383, PII: CIRCRESAHA.110.235630, DOI: 10.1161/CIRCRESAHA.110.235630, ISSN: 1524-4571.

Yang T, McBride BF, Leake BF, Kim RB, Roden DM. Modulation of drug block of the cardiac potassium channel KCNA5 by the drug transporters OCTN1 and MDR1. Br. J. Pharmacol. 2010 Nov; 161(5): 1023-33. PMID: 20977453, PMCID: PMC2998684, DOI: 10.1111/j.1476-5381.2010.00932.x, ISSN: 1476-5381.

Yang T, Yang P, Roden DM, Darbar D. Novel KCNA5 mutation implicates tyrosine kinase signaling in human atrial fibrillation. Heart Rhythm [print-electronic]. 2010 Sep; 7(9): 1246-52. PMID: 20638934, PMCID: PMC2932792, PII: S1547-5271(10)00515-1, DOI: 10.1016/j.hrthm.2010.05.032, ISSN: 1556-3871.

Chopra SS, Stroud DM, Watanabe H, Bennett JS, Burns CG, Wells KS, Yang T, Zhong TP, Roden DM. Voltage-gated sodium channels are required for heart development in zebrafish. Circ. Res [print-electronic]. 2010 Apr 4/30/2010; 106(8): 1342-50. PMID: 20339120, PMCID: PMC2869449, PII: CIRCRESAHA.109.213132, DOI: 10.1161/CIRCRESAHA.109.213132, ISSN: 1524-4571.

Abraham RL, Yang T, Blair M, Roden DM, Darbar D. Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation. J. Mol. Cell. Cardiol [print-electronic]. 2010 Jan; 48(1): 181-90. PMID: 19646991, PMCID: PMC2813326, PII: S0022-2828(09)00312-5, DOI: 10.1016/j.yjmcc.2009.07.020, ISSN: 1095-8584.

Yang T, Chung SK, Zhang W, Mullins JG, McCulley CH, Crawford J, MacCormick J, Eddy CA, Shelling AN, French JK, Yang P, Skinner JR, Roden DM, Rees MI. Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome. Circ Arrhythm Electrophysiol [print-electronic]. 2009 Aug; 2(4): 417-26. PMID: 19808498, PMCID: PMC2748886, PII: CIRCEP.109.850149, DOI: 10.1161/CIRCEP.109.850149, ISSN: 1941-3084.

Yang T, Kanki H, Zhang W, Roden DM. Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation. Br. J. Pharmacol [print-electronic]. 2009 Jul; 157(6): 952-61. PMID: 19522859, PMCID: PMC2737654, PII: BPH293, DOI: 10.1111/j.1476-5381.2009.00293.x, ISSN: 1476-5381.

McBride BF, Yang T, Roden DM. Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and ibutilide-induced block of HERG. Pharmacogenomics J [print-electronic]. 2009 Jun; 9(3): 194-201. PMID: 19204737, PMCID: PMC3775644, PII: tpj20091, DOI: 10.1038/tpj.2009.1, ISSN: 1473-1150.

Chopra N, Yang T, Asghari P, Moore ED, Huke S, Akin B, Cattolica RA, Perez CF, Hlaing T, Knollmann-Ritschel BE, Jones LR, Pessah IN, Allen PD, Franzini-Armstrong C, Knollmann BC. Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2009 May 5/5/2009; 106(18): 7636-41. PMID: 19383796, PMCID: PMC2678594, PII: 0902919106, DOI: 10.1073/pnas.0902919106, ISSN: 1091-6490.

Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram CR, Schott JJ, Demolombe S, Probst V, Anselme F, Escande D, Wiesfeld AC, Pfeufer A, Kääb S, Wichmann HE, Hasdemir C, Aizawa Y, Wilde AA, Roden DM, Bezzina CR. Sodium channel ß1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J. Clin. Invest. 2008 Jun; 118(6): 2260-8. PMID: 18464934, PMCID: PMC2373423, DOI: 10.1172/JCI33891, ISSN: 0021-9738.

Chopra N, Kannankeril PJ, Yang T, Hlaing T, Holinstat I, Ettensohn K, Pfeifer K, Akin B, Jones LR, Franzini-Armstrong C, Knollmann BC. Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice. Circ. Res [print-electronic]. 2007 Sep 9/14/2007; 101(6): 617-26. PMID: 17656677, PII: CIRCRESAHA.107.157552, DOI: 10.1161/CIRCRESAHA.107.157552, ISSN: 1524-4571.

Liu K, Hipkens S, Yang T, Abraham R, Zhang W, Chopra N, Knollmann B, Magnuson MA, Roden DM. Recombinase-mediated cassette exchange to rapidly and efficiently generate mice with human cardiac sodium channels. Genesis. 2006 Nov; 44(11): 556-64. PMID: 17083109, DOI: 10.1002/dvg.20247, ISSN: 1526-954X.

Knollmann BC, Chopra N, Hlaing T, Akin B, Yang T, Ettensohn K, Knollmann BE, Horton KD, Weissman NJ, Holinstat I, Zhang W, Roden DM, Jones LR, Franzini-Armstrong C, Pfeifer K. Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J. Clin. Invest [print-electronic]. 2006 Sep; 116(9): 2510-20. PMID: 16932808, PMCID: PMC1551934, DOI: 10.1172/JCI29128, ISSN: 0021-9738.

Liu K, Yang T, Viswanathan PC, Roden DM. New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant. Circulation. 2005 Nov 11/22/2005; 112(21): 3239-46. PMID: 16301357, PII: 112/21/3239, DOI: 10.1161/CIRCULATIONAHA.105.564008, ISSN: 1524-4539.

Darbar D, Yang T, Churchwell K, Wilde AA, Roden DM. Unmasking of brugada syndrome by lithium. Circulation [print-electronic]. 2005 Sep 9/13/2005; 112(11): 1527-31. PMID: 16144991, PMCID: PMC1350464, PII: CIRCULATIONAHA.105.548487, DOI: 10.1161/CIRCULATIONAHA.105.548487, ISSN: 1524-4539.

Temple J, Frias P, Rottman J, Yang T, Wu Y, Verheijck EE, Zhang W, Siprachanh C, Kanki H, Atkinson JB, King P, Anderson ME, Kupershmidt S, Roden DM. Atrial fibrillation in KCNE1-null mice. Circ. Res [print-electronic]. 2005 Jul 7/8/2005; 97(1): 62-9. PMID: 15947250, PII: 01.RES.0000173047.42236.88, DOI: 10.1161/01.RES.0000173047.42236.88, ISSN: 1524-4571.

Darbar D, Roden DM, Ali MF, Yang T, Wathen MS. Images in cardiovascular medicine. Himalayan T waves in the congenital long-QT syndrome. Circulation. 2005 Mar 3/22/2005; 111(11): e161. PMID: 15781747, PII: 111/11/e161, DOI: 10.1161/01.CIR.0000159092.92366.CD, ISSN: 1524-4539.

Roden DM, Yang T. Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve (Editorial). Circulation. 2005; 112((10)): 1376-8.

Kanki H, Kupershmidt S, Yang T, Wells S, Roden DM. A structural requirement for processing the cardiac K+ channel KCNQ1. J. Biol. Chem [print-electronic]. 2004 Aug 8/6/2004; 279(32): 33976-83. PMID: 15140888, PII: M404539200, DOI: 10.1074/jbc.M404539200, ISSN: 0021-9258.

Brame CJ, Boutaud O, Davies SS, Yang T, Oates JA, Roden D, Roberts LJ. Modification of proteins by isoketal-containing oxidized phospholipids. J. Biol. Chem [print-electronic]. 2004 Apr 4/2/2004; 279(14): 13447-51. PMID: 14715668, PII: M313349200, DOI: 10.1074/jbc.M313349200, ISSN: 0021-9258.

Yang T, Kanki H, Roden DM. Phosphorylation of the IKs channel complex inhibits drug block: novel mechanism underlying variable antiarrhythmic drug actions. Circulation [print-electronic]. 2003 Jul 7/15/2003; 108(2): 132-4. PMID: 12835205, PII: 01.CIR.0000082708.86266.B8, DOI: 10.1161/01.CIR.0000082708.86266.B8, ISSN: 1524-4539.

Drolet B, Yang T, Daleau P, Roden DM, Turgeon J. Risperidone prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current. J. Cardiovasc. Pharmacol. 2003 Jun; 41(6): 934-7. PMID: 12775973, ISSN: 0160-2446.

Johnson, Walter H, Yang, Ping, Yang, Tao, Lau, Yung R, Mostella, Barbara A, Wolff, Daynna J, Roden, Dan M, Benson, D Woodrow. Clinical, genetic, and biophysical characterization of a homozygous HERG mutation causing severe neonatal long QT syndrome. Pediatr Res. 2003; 53((5)): 744-8.

Kupershmidt S, Yang IC, Sutherland M, Wells KS, Yang T, Yang P, Balser JR, Roden DM. Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system. Cardiovasc. Res. 2002 Oct; 56(1): 93-103. PMID: 12237170, PII: S0008636302004984, ISSN: 0008-6363.

Kupershmidt S, Yang T, Chanthaphaychith S, Wang Z, Towbin JA, Roden DM. Defective human Ether-à-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus. J. Biol. Chem [print-electronic]. 2002 Jul 7/26/2002; 277(30): 27442-8. PMID: 12021266, PII: M112375200, DOI: 10.1074/jbc.M112375200, ISSN: 0021-9258.

Yang P, Kanki H, Drolet B, Yang T, Wei J, Viswanathan PC, Hohnloser SH, Shimizu W, Schwartz PJ, Stanton M, Murray KT, Norris K, George AL, Roden DM. Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes. Circulation. 2002 Apr 4/23/2002; 105(16): 1943-8. PMID: 11997281, ISSN: 1524-4539.

Yang T, Snyders D, Roden DM. Drug block of I(kr): model systems and relevance to human arrhythmias. J. Cardiovasc. Pharmacol. 2001 Nov; 38(5): 737-44. PMID: 11602820, ISSN: 0160-2446.

Anderson ME, Mazur A, Yang T, Roden DM. Potassium current antagonist properties and proarrhythmic consequences of quinolone antibiotics. J. Pharmacol. Exp. Ther. 2001 Mar; 296(3): 806-10. PMID: 11181910, ISSN: 0022-3565.

Kupershmidt S, Yang T, Anderson ME, Wessels A, Niswender KD, Magnuson MA, Roden DM. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circ. Res. 1999 Feb 2/5/1999; 84(2): 146-52. PMID: 9933245, ISSN: 0009-7330.

Kupershmidt S, Yang T, Roden DM. Modulation of cardiac Na+ current phenotype by beta1-subunit expression. Circ. Res. 1998 Aug 8/24/1998; 83(4): 441-7. PMID: 9721701, ISSN: 0009-7330.

Yang T, Snyders DJ, Roden DM. Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells. Circ. Res. 1997 Jun; 80(6): 782-9. PMID: 9168780, ISSN: 0009-7330.

Yang T, Snyders DJ, Roden DM. Inhibition of cardiac potassium currents by the vesnarinone analog OPC-18790: comparison with quinidine and dofetilide. J. Pharmacol. Exp. Ther. 1997 Mar; 280(3): 1170-5. PMID: 9067300, ISSN: 0022-3565.

Yang T, Roden DM. Regulation of sodium current development in cultured atrial tumor myocytes (AT-1 cells). Am. J. Physiol. 1996 Aug; 271(2 Pt 2): H541-7. PMID: 8770095, ISSN: 0002-9513.

Yang T, Roden DM. Extracellular potassium modulation of drug block of IKr. Implications for torsade de pointes and reverse use-dependence. Circulation. 1996 Feb 2/1/1996; 93(3): 407-11. PMID: 8565156, ISSN: 0009-7322.

Yang T, Kupershmidt S, Roden DM. Anti-minK antisense decreases the amplitude of the rapidly activating cardiac delayed rectifier K+ current. Circ. Res. 1995 Dec; 77(6): 1246-53. PMID: 7586238, ISSN: 0009-7330.

Yang T, Prakash C, Roden DM, Snyders DJ. Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers. Br. J. Pharmacol. 1995 May; 115(2): 267-74. PMID: 7670728, PMCID: PMC1908306, ISSN: 0007-1188.

Yang T, Snyders DJ, Roden DM. Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995 Mar 3/15/1995; 91(6): 1799-806. PMID: 7882490, ISSN: 0009-7322.

Yang T, Wathen MS, Felipe A, Tamkun MM, Snyders DJ, Roden DM. K+ currents and K+ channel mRNA in cultured atrial cardiac myocytes (AT-1 cells). Circ. Res. 1994 Nov; 75(5): 870-8. PMID: 7923633, ISSN: 0009-7330.