Ryszard Dworski, M.D., Ph.D.

Associate Professor

ryszard.dworski@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
Ph.D., Jagiellonian University, Krakow, PolandM.D., Jagiellonian University, Krakow, Poland
Office Address
T-1218 MCN
TN 2650
Publications
Sebag SC, Koval OM, Paschke JD, Winters CJ, Jaffer OA, Dworski R, Sutterwala FS, Anderson ME, Grumbach IM. Mitochondrial CaMKII inhibition in airway epithelium protects against allergic asthma. JCI Insight. 2017 Feb 2/9/2017; 2(3): e88297. PMID: 28194433, PMCID: PMC5291733, PII: 88297, DOI: 10.1172/jci.insight.88297, ISSN: 2379-3708.

Murray TS, Rice TW, Wheeler AP, Phillips EJ, Dworski RT, Stollings JL. Medication Desensitization: Characterization of Outcomes and Risk Factors for Reactions. Ann Pharmacother [print-electronic]. 2016 Mar; 50(3): 203-8. PMID: 26783356, PII: 1060028015625660, DOI: 10.1177/1060028015625660, ISSN: 1542-6270.

Lauer ME, Majors AK, Comhair S, Ruple LM, Matuska B, Subramanian A, Farver C, Dworski R, Grandon D, Laskowski D, Dweik RA, Erzurum SC, Hascall VC, Aronica MA. Hyaluronan and Its Heavy Chain Modification in Asthma Severity and Experimental Asthma Exacerbation. J. Biol. Chem [print-electronic]. 2015 Sep 9/18/2015; 290(38): 23124-34. PMID: 26209637, PMCID: PMC4645592, PII: M115.663823, DOI: 10.1074/jbc.M115.663823, ISSN: 1083-351X.

Polosukhin VV, Polosukhin IV, Hoskins A, Han W, Abdolrasulnia R, Blackwell TS, Dworski R. Glutathione S-transferase M1 modulates allergen-induced NF-¿B activation in asthmatic airway epithelium. Allergy [print-electronic]. 2014 Dec; 69(12): 1666-72. PMID: 25118837, PMCID: PMC4317365, DOI: 10.1111/all.12506, ISSN: 1398-9995.

Karlin E, Allinder JM, Dworski R, Stollings JL. Rapid Oral Desensitization to Everolimus. Ann Pharmacother [print-electronic]. 2014 May 5/8/2014; 48(8): 1095-6. PMID: 24811399, PII: 1060028014535200, DOI: 10.1177/1060028014535200, ISSN: 1542-6270.

Norton A, Smith K, James K, Hoskins A, Scott TA, Plunkett G, Fahrenholz J, Dworski R. Diagnostic utility of concentrated Mus m 1 allergen extract in humans [letter]. Ann. Allergy Asthma Immunol [print-electronic]. 2014 Apr; 112(4): 391-2. PMID: 24583136, PMCID: PMC4005333, PII: S1081-1206(14)00084-2, DOI: 10.1016/j.anai.2014.01.024, ISSN: 1534-4436.

Hoskins A, Wu P, Reiss S, Dworski R. Glutathione S-transferase P1 Ile105Val polymorphism modulates allergen-induced airway inflammation in human atopic asthmatics in vivo. Clin. Exp. Allergy. 2013 May; 43(5): 527-34. PMID: 23600543, PMCID: PMC3633143, DOI: 10.1111/cea.12086, ISSN: 1365-2222.

Hoskins A, Reiss S, Wu P, Chen N, Han W, Do RH, Abdolrasulnia R, Dworski R. Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype. Am. J. Respir. Crit. Care Med [print-electronic]. 2013 Jan 1/1/2013; 187(1): 34-41. PMID: 23204253, PMCID: PMC3570644, PII: rccm.201204-0786OC, DOI: 10.1164/rccm.201204-0786OC, ISSN: 1535-4970.

Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N, Ware LB. Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax [print-electronic]. 2012 Dec; 67(12): 1032-9. PMID: 23033361, PMCID: PMC3652432, PII: thoraxjnl-2012-201781, DOI: 10.1136/thoraxjnl-2012-201781, ISSN: 1468-3296.

Majeski E, Hoskins A, Dworski R, Sheller JR. Iloprost inhalation in mild asthma. J Asthma [print-electronic]. 2012 Nov; 49(9): 961-5. PMID: 23033807, DOI: 10.3109/02770903.2012.724130, ISSN: 1532-4303.

Hoskins A, Roberts JL, Milne G, Choi L, Dworski R. Natural-source d-a-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo. Allergy [print-electronic]. 2012 May; 67(5): 676-82. PMID: 22435735, PMCID: PMC3476459, DOI: 10.1111/j.1398-9995.2012.02810.x, ISSN: 1398-9995.

Dworski R, Han W, Blackwell TS, Hoskins A, Freeman ML. Vitamin E prevents NRF2 suppression by allergens in asthmatic alveolar macrophages in vivo. Free Radic. Biol. Med [print-electronic]. 2011 Jul 7/15/2011; 51(2): 516-21. PMID: 21605660, PMCID: PMC3439844, PII: S0891-5849(11)00281-4, DOI: 10.1016/j.freeradbiomed.2011.04.040, ISSN: 1873-4596.

Dworski R, Simon HU, Hoskins A, Yousefi S. Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways. J. Allergy Clin. Immunol [print-electronic]. 2011 May; 127(5): 1260-6. PMID: 21315435, PMCID: PMC3085562, PII: S0091-6749(11)00008-X, DOI: 10.1016/j.jaci.2010.12.1103, ISSN: 1097-6825.

Rock M, Yoder S, Hoskins A, Ajayi WU, Sheller JR, Dworski R. Effect of allergen challenge on the percentage of natural killer T cells in patients with atopic asthma. Ann. Allergy Asthma Immunol. 2009 May; 102(5): 432-7. PMID: 19492667, ISSN: 1081-1206.

Jones JD, Temino VM, Dworski R, Anderson CK, Fahrenholz JM, An AQ. Use of olopatadine ophthalmic solution and reactivity of histamine skin testing. Allergy Asthma Proc. 2008 Nov; 29(6): 636-9. PMID: 19173791, DOI: 10.2500/aap.2008.29.3173, ISSN: 1088-5412.

Talati M, Meyrick B, Peebles RS, Davies SS, Dworski R, Mernaugh R, Mitchell D, Boothby M, Roberts LJ, Sheller JR. Oxidant stress modulates murine allergic airway responses. Free Radic. Biol. Med [print-electronic]. 2006 Apr 4/1/2006; 40(7): 1210-9. PMID: 16545689, PII: S0891-5849(05)00710-0, DOI: 10.1016/j.freeradbiomed.2005.11.012, ISSN: 0891-5849.

Sheller J, Dworski R, Hagaman D, Oates J, Murray J. The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. Prostaglandins Other Lipid Mediat. 2002 Sep; 70(1-2): 185-93. PMID: 12428688, ISSN: 1098-8823.

Peebles RS, Hashimoto K, Morrow JD, Dworski R, Collins RD, Hashimoto Y, Christman JW, Kang KH, Jarzecka K, Furlong J, Mitchell DB, Talati M, Graham BS, Sheller JR. Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 2002 Apr 4/15/2002; 165(8): 1154-60. PMID: 11956061, DOI: 10.1164/ajrccm.165.8.2106025, ISSN: 1073-449X.

Cruz-Gervis R, Stecenko AA, Dworski R, Lane KB, Loyd JE, Pierson R, King G, Brigham KL. Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis. Respir. Res [print-electronic]. 2002; 3: 17. PMID: 11980586, PMCID: PMC107846, ISSN: 1465-993X.

Stecenko AA, King G, Torii K, Breyer RM, Dworski R, Blackwell TS, Christman JW, Brigham KL. Dysregulated cytokine production in human cystic fibrosis bronchial epithelial cells. Inflammation. 2001 Jun; 25(3): 145-55. PMID: 11403205, ISSN: 0360-3997.

Dworski R, Roberts LJ, Murray JJ, Morrow JD, Hartert TV, Sheller JR. Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha). Clin. Exp. Allergy. 2001 Mar; 31(3): 387-90. PMID: 11260149, PII: cea1055, ISSN: 0954-7894.

Dworski R, Christman BW, Sheller JR. Quantitative analysis of f(2) isoprostanes. Methods Mol. Med. 2001; 56: 423-30. PMID: 21336919, DOI: 10.1385/1-59259-151-5:423, ISSN: 1543-1894.

Dworski R, Sheller JR, Christman BW. Quantitative analysis of cyclooxygenase metabolites of arachidonic Acid. Methods Mol. Med. 2001; 56: 411-22. PMID: 21336918, DOI: 10.1385/1-59259-151-5:411, ISSN: 1543-1894.

Dworski R. Oxidant stress in asthma. Thorax. 2000 Oct; 55 Suppl 2: S51-3. PMID: 10992559, PMCID: PMC1765968, ISSN: 0040-6376.

Brightling CE, Ward R, Woltmann G, Bradding P, Sheller JR, Dworski R, Pavord ID. Induced sputum inflammatory mediator concentrations in eosinophilic bronchitis and asthma. Am. J. Respir. Crit. Care Med. 2000 Sep; 162(3 Pt 1): 878-82. PMID: 10988099, DOI: 10.1164/ajrccm.162.3.9909064, ISSN: 1073-449X.

Peebles RS, Dworski R, Collins RD, Jarzecka K, Mitchell DB, Graham BS, Sheller JR. Cyclooxygenase inhibition increases interleukin 5 and interleukin 13 production and airway hyperresponsiveness in allergic mice. Am. J. Respir. Crit. Care Med. 2000 Aug; 162(2 Pt 1): 676-81. PMID: 10934105, DOI: 10.1164/ajrccm.162.2.9911063, ISSN: 1073-449X.

Hartert TV, Dworski RT, Mellen BG, Oates JA, Murray JJ, Sheller JR. Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma. Am. J. Respir. Crit. Care Med. 2000 Aug; 162(2 Pt 1): 637-40. PMID: 10934099, DOI: 10.1164/ajrccm.162.2.9904038, ISSN: 1073-449X.

Dworski R, Murray JJ, Roberts LJ, Oates JA, Morrow JD, Fisher L, Sheller JR. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am. J. Respir. Crit. Care Med. 1999 Dec; 160(6): 1947-51. PMID: 10588611, DOI: 10.1164/ajrccm.160.6.9903064, ISSN: 1073-449X.

Morrow JD, Zackert WE, Yang JP, Kurhts EH, Callewaert D, Dworski R, Kanai K, Taber D, Moore K, Oates JA, Roberts LJ. Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 1999 May 5/1/1999; 269(2): 326-31. PMID: 10222005, PII: S0003-2697(99)94008-3, DOI: 10.1006/abio.1999.4008, ISSN: 0003-2697.

Dworski R, Sheller JR. Differential sensitivities of human blood monocytes and alveolar macrophages to the inhibition of prostaglandin endoperoxide synthase-2 by interleukin-4. Prostaglandins. 1997 Apr; 53(4): 237-51. PMID: 9167211, PII: S0090698097895986, ISSN: 0090-6980.

Dworski RT, Funk CD, Oates JA, Sheller JR. Prednisone increases PGH-synthase 2 in atopic humans in vivo. Am. J. Respir. Crit. Care Med. 1997 Jan; 155(1): 351-7. PMID: 9001335, DOI: 10.1164/ajrccm.155.1.9001335, ISSN: 1073-449X.

Dworski R, Sheller JR. New therapies for asthma. Compr Ther. 1994; 20(11): 611-5. PMID: 7851091, ISSN: 0098-8243.

Christman BW, Christman JW, Dworski R, Blair IA, Prakash C. Prostaglandin E2 limits arachidonic acid availability and inhibits leukotriene B4 synthesis in rat alveolar macrophages by a nonphospholipase A2 mechanism. J. Immunol. 1993 Aug 8/15/1993; 151(4): 2096-104. PMID: 8393898, ISSN: 0022-1767.

Dworski R, Sheller J. Inhaled steroids in asthma. Compr Ther. 1992 Mar; 18(3): 3-5. PMID: 1572148, ISSN: 0098-8243.

Dworski R, FitzGerald GA, Sheller JR. Thromboxane synthase inhibition in allergen challenged sheep lung: effect on eicosanoid synthesis. Eicosanoids. 1992; 5(1): 35-7. PMID: 1419078, ISSN: 0934-9820.

Sladek K, Dworski R, Fitzgerald GA, Buitkus KL, Block FJ, Marney SR, Sheller JR. Allergen-stimulated release of thromboxane A2 and leukotriene E4 in humans. Effect of indomethacin. Am. Rev. Respir. Dis. 1990 Jun; 141(6): 1441-5. PMID: 2161626, DOI: 10.1164/ajrccm/141.6.1441, ISSN: 0003-0805.

Dworski R, Sheller JR, Wickersham NE, Oates JA, Brigham KL, Roberts LJ, Fitzgerald GA. Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition. Am. Rev. Respir. Dis. 1989 Jan; 139(1): 46-51. PMID: 2492175, DOI: 10.1164/ajrccm/139.1.46, ISSN: 0003-0805.