Luc Van Kaer, Ph.D.


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Faculty Appointments
Professor of Pathology, Microbiology and Immunology Elizabeth and John Shapiro Chair
Ph.D., Molecular Biology, University of Ghent, Ghent, BelgiumM.S., Biotechnology, University of Ghent, Ghent, BelgiumB.S., Chemistry, University of Ghent, Ghent, Belgium
Research Description
Interactions between the Immune and Metabolic Systems

Our research is broadly focused on interactions between the immune and metabolic systems, an emerging field referred to as immunometabolism. We have a long-standing interest in the immunological functions of innate and innate-like lymphocytes, and we have investigated the contributions of subsets of innate-like lymphocytes to the development of obesity-associated metabolic diseases. A more recent research direction is the role of autophagy, a cellular self-eating process induced by starvation and other types of stress, in the development and function of distinct immune cells, and in the generation of metabolic disease. The long-term goal of these studies is to manipulate immune and metabolic pathways for the development of new therapies for human disease.

Innate-like lymphocytes and their contribution to metabolic disease:
The immune system contains two main arms: an innate arm and an adaptive arm. Cells of the innate immune system express germline-encoded receptors that recognize conserved molecular patterns in microbes as well as in dead or stressed host cells, whereas cells of the adaptive immune system express highly diverse antigen-specific receptors that are generated by somatic DNA recombination. Lymphocytes that belong to both the innate and adaptive arms of the immune system play critical roles in regulating immune responses against pathogens, tumors, self-antigens, environmental antigens and tissue transplants.
The immune system also contains subsets of lymphocytes that cannot be easily classified as either innate or adaptive, and these cells are instead called innate-like lymphocytes or “inbetweeners”. Such lymphocytes express antigen-specific receptors characteristic of the adaptive immune system, yet their effector functions are more similar to cells of the innate immune system. Our lab focuses on two subsets of innate-like lymphocytes: invariant natural killer T (iNKT) cells and regulatory B (Breg) cells.

Autophagy in metabolic disease and immune cell function:
Autophagy is an evolutionarily conserved nutrient sensing system that induces the degradation of cytoplasmic proteins and damaged organelles by lysosomes. The resulting degradation products are then used to generate energy and new cellular components. Autophagy involves a variety of protein complexes composed of autophagy-related gene (Atg) products that were originally identified in yeast but are largely conserved in mammals (Figure 5). Autophagy plays a role in a variety of diseases, including the metabolic syndrome. In the immune system, autophagy has been implicated in both innate and adaptive immune responses.
We have focused on a key player in autophagy, the class III phosphatidylinositol-3 kinase (PI3K) vacuolar protein sorting 34 (Vps34). Because Vps34-deficiency is incompatible with life, we are generating and analyzing mice with a selective Vps34-deficiency in specific cell types of the metabolic and immune systems.
Research Keywords
Antigen presentation, lymphocyte development, MHC molecules, innate lymphocytes, innate-like lymphocytes, autoimmunity, autophagy, metabolic disease, diabetes, obesity, immunology, immunobiology, immunometabolism
Chioma OS, Mallott E, Shah-Gandhi B, Wiggins Z, Langford M, Lancaster AW, Gelbard A, Wu H, Johnson JE, Lancaster L, Wilfong EM, Crofford LJ, Montgomery CG, Van Kaer L, Bordenstein S, Newcomb DC, Drake WP. Low Gut Microbial Diversity Augments Estrogen-driven Pulmonary Fibrosis in Female-Predominant Interstitial Lung Disease. BioRxiv. 2023 Feb 2/15/2023; PMID: 36824732, PMCID: PMC9948999, PII: 2023.02.15.528630, DOI: 10.1101/2023.02.15.528630.

Song W, Postoak JL, Wu L, Van Kaer L. PIK3C3/VPS34 keeps body fats healthy. Autophagy [print-electronic]. 2023 Jan 1/18/2023; 1-3. PMID: 36629752, DOI: 10.1080/15548627.2023.2166275, ISSN: 1554-8635.

Van Kaer L. LEF1 Creates Memories in iNKT Cells That Potentiate Antitumor Immunity [editorial]. Cancer Immunol Res [print-electronic]. 2023 Jan 1/11/2023; OF1. PMID: 36630221, PII: 714869, DOI: 10.1158/2326-6066.CIR-22-0902, ISSN: 2326-6074.

Song W, Postoak JL, Yang G, Guo X, Pua HH, Bader J, Rathmell JC, Kobayashi H, Haase VH, Leaptrot KL, Schrimpe-Rutledge AC, Sherrod SD, McLean JA, Zhang J, Wu L, Van Kaer L. Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases. Proc Natl Acad Sci U S A [print-electronic]. 2023 Jan 1/3/2023; 120(1): e2214874120. PMID: 36574710, DOI: 10.1073/pnas.2214874120, ISSN: 1091-6490.

Lee SW, Oh SY, Park HJ, Kim TC, Park YH, Van Kaer L, Hong S. Phosphorothioate-linked guanine/cytosine-based stem-loop oligonucleotides induce the extracellular release of mitochondrial DNA from peritoneal B1a cells. Int J Biol Macromol [print-electronic]. 2022 Dec 12/31/2022; 223(Pt A): 252-62. PMID: 36347365, PII: S0141-8130(22)02533-8, DOI: 10.1016/j.ijbiomac.2022.10.280, ISSN: 1879-0003.

Park HJ, Lee SW, Song JG, Van Kaer L, Cheon JH, Lim SJ, Han HK, Hong S. Aminoclay Nanoparticles Induce Anti-Inflammatory Dendritic Cells to Attenuate LPS-Elicited Pro-Inflammatory Immune Responses. Molecules. 2022 Dec 12/9/2022; 27(24): PMID: 36557876, PMCID: PMC9787634, PII: molecules27248743, DOI: 10.3390/molecules27248743, ISSN: 1420-3049.

Lee SW, Park HJ, Van Kaer L, Hong S. Opposing Roles of DCs and iNKT Cells in the Induction of Foxp3 Expression by MLN CD25+CD4+ T Cells during IFN¿-Driven Colitis. Int J Mol Sci. 2022 Dec 12/5/2022; 23(23): PMID: 36499642, PMCID: PMC9738888, PII: ijms232315316, DOI: 10.3390/ijms232315316, ISSN: 1422-0067.

Postoak JL, Song W, Wu L, Van Kaer L. PIK3C3/VPS34 helps school T cells in the thymus. Autophagy [print-electronic]. 2022 Nov 11/23/2022; 1-3. PMID: 36394336, DOI: 10.1080/15548627.2022.2148428, ISSN: 1554-8635.

Postoak JL, Song W, Yang G, Guo X, Xiao S, Saffold CE, Zhang J, Joyce S, Manley NR, Wu L, Van Kaer L. Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection. J Exp Med [print-electronic]. 2022 Oct 10/3/2022; 219(10): PMID: 35997680, PMCID: PMC9402993, PII: 213417, DOI: 10.1084/jem.20212554, ISSN: 1540-9538.

Van Kaer L, Postoak JL, Song W, Wu L. Innate and Innate-like Effector Lymphocytes in Health and Disease. J Immunol. 2022 Jul 7/15/2022; 209(2): 199-207. PMID: 35821102, PMCID: PMC9285656, PII: jimmunol.2200074, DOI: 10.4049/jimmunol.2200074, ISSN: 1550-6606.

Satoh M, Iizuka M, Majima M, Ohwa C, Hattori A, Van Kaer L, Iwabuchi K. Adipose invariant NKT cells interact with CD1d-expressing macrophages to regulate obesity-related inflammation. Immunology [print-electronic]. 2022 Apr; 165(4): 414-27. PMID: 35137411, DOI: 10.1111/imm.13447, ISSN: 1365-2567.

Lee SW, Park HJ, Van Kaer L, Hong S. Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases. Front Immunol. 2022; 13: 979370. PMID: 36119077, PMCID: PMC9478174, DOI: 10.3389/fimmu.2022.979370, ISSN: 1664-3224.

Park HJ, Lee SW, Park YH, Kim TC, Van Kaer L, Hong S. CD1d-independent NK1.1+ Treg cells are IL2-inducible Foxp3+ T cells co-expressing immunosuppressive and cytotoxic molecules. Front Immunol. 2022; 13: 951592. PMID: 36177042, PMCID: PMC9513232, DOI: 10.3389/fimmu.2022.951592, ISSN: 1664-3224.

Park HJ, Kim TC, Park YH, Lee SW, Jeon J, Park SH, Van Kaer L, Hong S. Repeated a-GalCer Administration Induces a Type 2 Cytokine-Biased iNKT Cell Response and Exacerbates Atopic Skin Inflammation in Va14Tg NC/Nga Mice. Biomedicines. 2021 Nov 11/4/2021; 9(11): PMID: 34829848, PMCID: PMC8615984, PII: biomedicines9111619, DOI: 10.3390/biomedicines9111619, ISSN: 2227-9059.

Park HJ, Lee SW, Park SH, Van Kaer L, Hong S. Selective Expansion of Double-Negative iNKT Cells Inhibits the Development of Atopic Dermatitis in Va14 TCR Transgenic NC/Nga Mice by Increasing Memory-Type CD8+ T and Regulatory CD4+ T Cells. J Invest Dermatol [print-electronic]. 2021 Jun; 141(6): 1512-21. PMID: 33186589, PII: S0022-202X(20)32283-1, DOI: 10.1016/j.jid.2020.09.030, ISSN: 1523-1747.

Yang G, Postoak JL, Song W, Martinez J, Zhang J, Wu L, Van Kaer L. Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis. Autophagy [print-electronic]. 2021 May 5/7/2021; 1-10. PMID: 33960279, DOI: 10.1080/15548627.2021.1922051, ISSN: 1554-8635.

Yang G, Song W, Postoak JL, Chen J, Martinez J, Zhang J, Wu L, Van Kaer L. Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function. Autophagy [print-electronic]. 2021 May; 17(5): 1193-204. PMID: 32268825, PMCID: PMC8143264, DOI: 10.1080/15548627.2020.1752979, ISSN: 1554-8635.

Postoak JL, Yang G, Wu L, Van Kaer L. Cellular self-cannibalism helps immune cells fight the flu. FEBS J [print-electronic]. 2021 May; 288(10): 3154-8. PMID: 33411418, PMCID: PMC8131204, DOI: 10.1111/febs.15641, ISSN: 1742-4658.

Lee SW, Park HJ, Jeon J, Park YH, Kim TC, Jeon SH, Seong RH, Van Kaer L, Hong S. Chromatin Regulator SRG3 Overexpression Protects against LPS/D-GalN-Induced Sepsis by Increasing IL10-Producing Macrophages and Decreasing IFN¿-Producing NK Cells in the Liver. Int J Mol Sci. 2021 Mar 3/16/2021; 22(6): PMID: 33809795, PMCID: PMC8002522, PII: ijms22063043, DOI: 10.3390/ijms22063043, ISSN: 1422-0067.

Lee SW, Park HJ, Jeon J, Park YH, Kim TC, Jeon SH, Seong RH, Van Kaer L, Hong S. Ubiquitous Overexpression of Chromatin Remodeling Factor SRG3 Exacerbates Atopic Dermatitis in NC/Nga Mice by Enhancing Th2 Immune Responses. Int J Mol Sci. 2021 Feb 2/4/2021; 22(4): PMID: 33557054, PMCID: PMC7913833, PII: ijms22041553, DOI: 10.3390/ijms22041553, ISSN: 1422-0067.

Park HJ, Lee SW, Van Kaer L, Hong S. CD1d-Dependent iNKT Cells Control DSS-Induced Colitis in a Mouse Model of IFN¿-Mediated Hyperinflammation by Increasing IL22-Secreting ILC3 Cells. Int J Mol Sci. 2021 Jan 1/27/2021; 22(3): PMID: 33513946, PMCID: PMC7866066, PII: ijms22031250, DOI: 10.3390/ijms22031250, ISSN: 1422-0067.

Jin WN, Shi K, He W, Sun JH, Van Kaer L, Shi FD, Liu Q. Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition. Nat Neurosci [print-electronic]. 2021 Jan; 24(1): 61-73. PMID: 33257875, PII: 10.1038/s41593-020-00745-w, DOI: 10.1038/s41593-020-00745-w, ISSN: 1546-1726.

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Yang G, Van Kaer L. Therapeutic Targeting of Immune Cell Autophagy in Multiple Sclerosis: Russian Roulette or Silver Bullet?. Front Immunol. 2021; 12: 724108. PMID: 34531871, PMCID: PMC8438236, DOI: 10.3389/fimmu.2021.724108, ISSN: 1664-3224.

Joyce S, Okoye GD, Van Kaer L. Natural Killer T Lymphocytes Integrate Innate Sensory Information and Relay Context to Effector Immune Responses. Crit Rev Immunol. 2021; 41(4): 55-88. PMID: 35381143, PII: 256bb987559bc247,4eb326212f45ca2d, DOI: 10.1615/CritRevImmunol.2021040076, ISSN: 1040-8401.

Van Kaer L. Preface: Unconventional T Cells in Health and Disease. Crit Rev Immunol. 2021; 41(4): v-ix. PMID: 36047319, PII: 256bb987559bc247,0a5e11032a13ba0a, DOI: 10.1615/CritRevImmunol.2021041608, ISSN: 1040-8401.

Yang G, Song W, Xu J, Postoak JL, Cheng F, Martinez J, Zhang J, Wu L, Van Kaer L. Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1ß production. Cell Mol Immunol [print-electronic]. 2020 Nov 11/24/2020; PMID: 33235386, PII: 10.1038/s41423-020-00589-1, DOI: 10.1038/s41423-020-00589-1, ISSN: 2042-0226.

Kumar A, Hill TM, Gordy LE, Suryadevara N, Wu L, Flyak AI, Bezbradica JS, Van Kaer L, Joyce S. Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells. Proc Natl Acad Sci U S A [print-electronic]. 2020 Jul 7/21/2020; 117(29): 17156-65. PMID: 32611812, PMCID: PMC7382224, PII: 2001665117, DOI: 10.1073/pnas.2001665117, ISSN: 1091-6490.

Van Kaer L, Joyce S. Survivre et vivre: When iNKT cells met a Hippo. J Exp Med. 2020 Jun 6/1/2020; 217(6): PMID: 32383750, PMCID: PMC7971142, PII: 151748, DOI: 10.1084/jem.20200343, ISSN: 1540-9538.

Yang G, Van Kaer L. PIK3C3/VPS34 links T-cell autophagy to autoimmunity. Cell Death Dis. 2020 May 5/7/2020; 11(5): 334. PMID: 32382030, PMCID: PMC7206076, PII: 10.1038/s41419-020-2568-z, DOI: 10.1038/s41419-020-2568-z, ISSN: 2041-4889.

Ahmad S, Bhattacharya D, Gupta N, Rawat V, Tousif S, Van Kaer L, Das G. Clofazimine enhances the efficacy of BCG revaccination via stem cell-like memory T cells. PLoS Pathog. 2020 May; 16(5): e1008356. PMID: 32437421, PMCID: PMC7269335, PII: PPATHOGENS-D-19-00896, DOI: 10.1371/journal.ppat.1008356, ISSN: 1553-7374.

Fatima S, Kamble SS, Dwivedi VP, Bhattacharya D, Kumar S, Ranganathan A, Van Kaer L, Mohanty S, Das G. Mycobacterium tuberculosis programs mesenchymal stem cells to establish dormancy and persistence. J. Clin. Invest. 2020 Feb 2/3/2020; 130(2): 655-61. PMID: 31647784, PMCID: PMC6994115, PII: 128043, DOI: 10.1172/JCI128043, ISSN: 1558-8238.

Joyce S, Spiller BW, Van Kaer L. What one lipid giveth, another taketh away. Nat. Immunol. 2019 Dec; 20(12): 1559-61. PMID: 31636467, PII: 10.1038/s41590-019-0525-8, DOI: 10.1038/s41590-019-0525-8, ISSN: 1529-2916.

Ahmad S, Bhattacharya D, Kar S, Ranganathan A, Van Kaer L, Das G. Curcumin Nanoparticles Enhance Mycobacterium bovis BCG Vaccine Efficacy by Modulating Host Immune Responses. Infect. Immun [electronic-print]. 2019 Nov; 87(11): PMID: 31481412, PMCID: PMC6803339, PII: IAI.00291-19, DOI: 10.1128/IAI.00291-19, ISSN: 1098-5522.

Wu L, Dalal R, Cao CD, Postoak JL, Yang G, Zhang Q, Wang Z, Lal H, Van Kaer L. IL-10-producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2019 Oct 10/22/2019; 116(43): 21673-84. PMID: 31591231, PMCID: PMC6815157, PII: 1911464116, DOI: 10.1073/pnas.1911464116, ISSN: 1091-6490.

Van Kaer L, Postoak JL, Wang C, Yang G, Wu L. Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE. Cell. Mol. Immunol [print-electronic]. 2019 Jun; 16(6): 531-9. PMID: 30874627, PII: 10.1038/s41423-019-0221-5, DOI: 10.1038/s41423-019-0221-5, ISSN: 2042-0226.

Park HJ, Lee SW, Im W, Kim M, Van Kaer L, Hong S. INKT Cell Activation Exacerbates the Development of Huntington's Disease in R6/2 Transgenic Mice. Mediators Inflamm. 2019; 2019: 3540974. PMID: 30766446, PMCID: PMC6350536, DOI: 10.1155/2019/3540974, ISSN: 1466-1861.

Imai T, Suzue K, Ngo-Thanh H, Ono S, Orita W, Suzuki H, Shimokawa C, Olia A, Obi S, Taniguchi T, Ishida H, Van Kaer L, Murata S, Tanaka K, Hisaeda H. Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii. Front Immunol. 2019; 10: 2207. PMID: 31608052, PMCID: PMC6773889, DOI: 10.3389/fimmu.2019.02207, ISSN: 1664-3224.

Iwabuchi K, Van Kaer L. Editorial: Role of CD1- and MR1-Restricted T Cells in Immunity and Disease [editorial]. Front Immunol. 2019; 10: 1837. PMID: 31447847, PMCID: PMC6691045, DOI: 10.3389/fimmu.2019.01837, ISSN: 1664-3224.

Van Kaer L. How Superantigens Bind MHC. J. Immunol. 2018 Oct 10/1/2018; 201(7): 1817-8. PMID: 30224360, PII: 201/7/1817, DOI: 10.4049/jimmunol.1801104, ISSN: 1550-6606.

Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP. PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-ß1 production. Sci Transl Med. 2018 Sep 9/26/2018; 10(460): PMID: 30257954, PMCID: PMC6263177, PII: 10/460/eaar8356, DOI: 10.1126/scitranslmed.aar8356, ISSN: 1946-6242.

Lee SW, Park HJ, Van Kaer L, Hong S, Hong S. Graphene oxide polarizes iNKT cells for production of TGFß and attenuates inflammation in an iNKT cell-mediated sepsis model. Sci Rep. 2018 Jul 7/4/2018; 8(1): 10081. PMID: 29973666, PMCID: PMC6031608, PII: 10.1038/s41598-018-28396-9, DOI: 10.1038/s41598-018-28396-9, ISSN: 2045-2322.

Van Kaer L, Olivares-Villagómez D. Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes. J. Immunol. 2018 Apr 4/1/2018; 200(7): 2235-44. PMID: 29555677, PMCID: PMC5863587, PII: 200/7/2235, DOI: 10.4049/jimmunol.1701704, ISSN: 1550-6606.

Stier MT, Zhang J, Goleniewska K, Cephus JY, Rusznak M, Wu L, Van Kaer L, Zhou B, Newcomb DC, Peebles RS. IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow. J. Exp. Med [print-electronic]. 2018 Jan 1/2/2018; 215(1): 263-81. PMID: 29222107, PMCID: PMC5748848, PII: jem.20170449, DOI: 10.1084/jem.20170449, ISSN: 1540-9538.

Van Kaer L, Wu L. Therapeutic Potential of Invariant Natural Killer T Cells in Autoimmunity. Front Immunol. 2018; 9: 519. PMID: 29593743, PMCID: PMC5859017, DOI: 10.3389/fimmu.2018.00519, ISSN: 1664-3224.

Lee SW, Park HJ, Cheon JH, Wu L, Van Kaer L, Hong S. INKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis. Front Immunol. 2018; 9: 2168. PMID: 30333822, PMCID: PMC6176072, DOI: 10.3389/fimmu.2018.02168, ISSN: 1664-3224.

Yang G, Driver JP, Van Kaer L. The Role of Autophagy in iNKT Cell Development. Front Immunol. 2018; 9: 2653. PMID: 30487800, PMCID: PMC6246678, DOI: 10.3389/fimmu.2018.02653, ISSN: 1664-3224.

Olivares-Villagómez D, Van Kaer L. Intestinal Intraepithelial Lymphocytes: Sentinels of the Mucosal Barrier. Trends Immunol [print-electronic]. 2017 Dec 12/5/2017; PMID: 29221933, PII: S1471-4906(17)30213-2, DOI: 10.1016/, ISSN: 1471-4981.

Kumar A, Gordy LE, Bezbradica JS, Stanic AK, Hill TM, Boothby MR, Van Kaer L, Joyce S. NF-¿B Protects NKT Cells from Tumor Necrosis Factor Receptor 1-induced Death. Sci Rep. 2017 Nov 11/15/2017; 7(1): 15594. PMID: 29142275, PMCID: PMC5688132, PII: 10.1038/s41598-017-15461-y, DOI: 10.1038/s41598-017-15461-y, ISSN: 2045-2322.

Van Kaer L, Parekh VV, Postoak JL, Wu L. Role of autophagy in MHC class I-restricted antigen presentation. Mol. Immunol [print-electronic]. 2017 Nov 11/8/2017; PMID: 29126597, PII: S0161-5890(17)30550-3, DOI: 10.1016/j.molimm.2017.10.021, ISSN: 1872-9142.

Parekh VV, Pabbisetty SK, Wu L, Sebzda E, Martinez J, Zhang J, Van Kaer L. Autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8a(+) dendritic cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2017 Aug 8/1/2017; 114(31): E6371-E6380. PMID: 28716903, PMCID: PMC5547642, PII: 1706504114, DOI: 10.1073/pnas.1706504114, ISSN: 1091-6490.

Kumar AA, Delgado AG, Piazuelo MB, Van Kaer L, Olivares-Villagómez D. Innate CD8aa(+) lymphocytes enhance anti-CD40 antibody-mediated colitis in mice. Immun Inflamm Dis [print-electronic]. 2017 Jun; 5(2): 109-23. PMID: 28474503, PMCID: PMC5418141, DOI: 10.1002/iid3.146, ISSN: 2050-4527.

Singh DK, Dwivedi VP, Ranganathan A, Bishai WR, Van Kaer L, Das G. Reply to Levis and Rendini. J. Infect. Dis. 2017 May 5/1/2017; 215(9): 1488-9. PMID: 28199694, PMCID: PMC5451602, PII: 2990218, DOI: 10.1093/infdis/jix084, ISSN: 1537-6613.

Dwivedi VP, Bhattacharya D, Yadav V, Singh DK, Kumar S, Singh M, Ojha D, Ranganathan A, Van Kaer L, Chattopadhyay D, Das G. The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages. Front Cell Infect Microbiol. 2017; 7: 149. PMID: 28507951, PMCID: PMC5410567, DOI: 10.3389/fcimb.2017.00149, ISSN: 2235-2988.

Tousif S, Singh DK, Mukherjee S, Ahmad S, Arya R, Nanda R, Ranganathan A, Bhattacharyya M, Van Kaer L, Kar SK, Das G. Nanoparticle-Formulated Curcumin Prevents Posttherapeutic Disease Reactivation and Reinfection with Mycobacterium tuberculosis following Isoniazid Therapy. Front Immunol. 2017; 8: 739. PMID: 28713372, PMCID: PMC5491555, DOI: 10.3389/fimmu.2017.00739, ISSN: 1664-3224.

Kumar A, Suryadevara N, Hill TM, Bezbradica JS, Van Kaer L, Joyce S. Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective. Front Immunol. 2017; 8: 1858. PMID: 29312339, PMCID: PMC5743650, DOI: 10.3389/fimmu.2017.01858, ISSN: 1664-3224.

Wei Y, Zeng B, Chen J, Cui G, Lu C, Wu W, Yang J, Wei H, Xue R, Bai L, Chen Z, Li L, Iwabuchi K, Uede T, Van Kaer L, Diao H. Enterogenous bacterial glycolipids are required for the generation of natural killer T cells mediated liver injury. Sci Rep. 2016 Nov 11/8/2016; 6: 36365. PMID: 27821872, PMCID: PMC5099575, PII: srep36365, DOI: 10.1038/srep36365, ISSN: 2045-2322.

Singh DK, Dwivedi VP, Ranganathan A, Bishai WR, Van Kaer L, Das G. Blockade of the Kv1.3 K+ Channel Enhances BCG Vaccine Efficacy by Expanding Central Memory T Lymphocytes. J. Infect. Dis [print-electronic]. 2016 Nov 11/1/2016; 214(9): 1456-64. PMID: 27571906, PII: jiw395, DOI: 10.1093/infdis/jiw395, ISSN: 1537-6613.

Satoh M, Namba KI, Kitaichi N, Endo N, Kitamei H, Iwata D, Ohno S, Ishida S, Onoé K, Watarai H, Taniguchi M, Ishibashi T, Stein-Streilein J, Sonoda KH, Van Kaer L, Iwabuchi K. Invariant natural killer T cells play dual roles in the development of experimental autoimmune uveoretinitis. Exp. Eye Res [print-electronic]. 2016 Oct 10/5/2016; 153: 79-89. PMID: 27720708, PII: S0014-4835(16)30317-7, DOI: 10.1016/j.exer.2016.10.003, ISSN: 1096-0007.

Van Kaer L, Wu L, Joyce S. Mechanisms and Consequences of Antigen Presentation by CD1. Trends Immunol [print-electronic]. 2016 Sep 9/9/2016; PMID: 27623113, PII: S1471-4906(16)30102-8, DOI: 10.1016/, ISSN: 1471-4981.

Liu Q, Sanai N, Jin WN, La Cava A, Van Kaer L, Shi FD. Neural stem cells sustain natural killer cells that dictate recovery from brain inflammation. Nat. Neurosci [print-electronic]. 2016 Feb; 19(2): 243-52. PMID: 26752157, PII: nn.4211, DOI: 10.1038/nn.4211, ISSN: 1546-1726.

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Yu L, Yu WH, Yu XF, Yu Z, Yuan J, Yuan ZM, Yue BY, Yue J, Yue Z, Zacks DN, Zacksenhaus E, Zaffaroni N, Zaglia T, Zakeri Z, Zecchini V, Zeng J, Zeng M, Zeng Q, Zervos AS, Zhang DD, Zhang F, Zhang G, Zhang GC, Zhang H, Zhang H, Zhang H, Zhang H, Zhang J, Zhang J, Zhang J, Zhang J, Zhang JP, Zhang L, Zhang L, Zhang L, Zhang L, Zhang MY, Zhang X, Zhang XD, Zhang Y, Zhang Y, Zhang Y, Zhang Y, Zhang Y, Zhao M, Zhao WL, Zhao X, Zhao YG, Zhao Y, Zhao Y, Zhao YX, Zhao Z, Zhao ZJ, Zheng D, Zheng XL, Zheng X, Zhivotovsky B, Zhong Q, Zhou GZ, Zhou G, Zhou H, Zhou SF, Zhou XJ, Zhu H, Zhu H, Zhu WG, Zhu W, Zhu XF, Zhu Y, Zhuang SM, Zhuang X, Ziparo E, Zois CE, Zoladek T, Zong WX, Zorzano A, Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1): 1-222. PMID: 26799652, PMCID: PMC4835977, DOI: 10.1080/15548627.2015.1100356, ISSN: 1554-8635.

Satoh M, Hoshino M, Fujita K, Iizuka M, Fujii S, Clingan CS, Van Kaer L, Iwabuchi K. Adipocyte-specific CD1d-deficiency mitigates diet-induced obesity and insulin resistance in mice. Sci Rep. 2016; 6: 28473. PMID: 27329323, PMCID: PMC4916414, PII: srep28473, DOI: 10.1038/srep28473, ISSN: 2045-2322.

Van Kaer L, Wu L, Parekh VV. Natural killer T cells in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Immunology [print-electronic]. 2015 Sep; 146(1): 1-10. PMID: 26032048, PMCID: PMC4552496, DOI: 10.1111/imm.12485, ISSN: 1365-2567.

Olivares-Villagómez D, Van Kaer L. ICD8a cells: living at the edge of the intestinal immune system [editorial]. Oncotarget. 2015 Aug 8/21/2015; 6(24): 19964-5. PMID: 26197090, PMCID: PMC4652978, PII: 4782, DOI: 10.18632/oncotarget.4782, ISSN: 1949-2553.

Van Kaer L. Innate and virtual memory T cells in man. Eur. J. Immunol [print-electronic]. 2015 Jul; 45(7): 1916-20. PMID: 26013879, PMCID: PMC4540369, DOI: 10.1002/eji.201545761, ISSN: 1521-4141.

Rahman MA, Sobia P, Dwivedi VP, Bhawsar A, Singh DK, Sharma P, Moodley P, Van Kaer L, Bishai WR, Das G. Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis. J. Biol. Chem [print-electronic]. 2015 Jun 6/5/2015; 290(23): 14407-17. PMID: 25847237, PMCID: PMC4505508, PII: M115.653600, DOI: 10.1074/jbc.M115.653600, ISSN: 1083-351X.

Van Kaer L. Bee venom stirs up buzz in antigen presentation. J. Exp. Med [print-electronic]. 2015 Feb 2/9/2015; 212(2): 126. PMID: 25646264, PMCID: PMC4322043, PII: jem.2122insight1, DOI: 10.1084/jem.2122insight1, ISSN: 1540-9538.

Lai CM, Boehme KW, Pruijssers AJ, Parekh VV, Van Kaer L, Parkos CA, Dermody TS. Endothelial JAM-A promotes reovirus viremia and bloodstream dissemination. J. Infect. Dis [print-electronic]. 2015 Feb 2/1/2015; 211(3): 383-93. PMID: 25149763, PMCID: PMC4351375, PII: jiu476, DOI: 10.1093/infdis/jiu476, ISSN: 1537-6613.

Van Kaer L, Parekh VV, Wu L. The Response of CD1d-Restricted Invariant NKT Cells to Microbial Pathogens and Their Products. Front Immunol. 2015; 6: 226. PMID: 26029211, PMCID: PMC4429631, DOI: 10.3389/fimmu.2015.00226, ISSN: 1664-3224.

Bali P, Tousif S, Das G, Van Kaer L. Strategies to improve BCG vaccine efficacy. Immunotherapy [print-electronic]. 2015; 7(9): 945-8. PMID: 26310608, DOI: 10.2217/imt.15.60, ISSN: 1750-7448.

Bhattacharya D, Dwivedi VP, Kumar S, Reddy MC, Van Kaer L, Moodley P, Das G. Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis. J. Biol. Chem [print-electronic]. 2014 Nov 11/28/2014; 289(48): 33404-11. PMID: 25315774, PMCID: PMC4246096, PII: M114.600452, DOI: 10.1074/jbc.M114.600452, ISSN: 1083-351X.

Ahmad R, Chaturvedi R, Olivares-Villagómez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Mucosal Immunol [print-electronic]. 2014 Nov; 7(6): 1340-53. PMID: 24670427, PMCID: PMC4221190, PII: mi201421, DOI: 10.1038/mi.2014.21, ISSN: 1935-3456.

Tousif S, Singh DK, Ahmad S, Moodley P, Bhattacharyya M, Van Kaer L, Das G. Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection. J. Biol. Chem [print-electronic]. 2014 Oct 10/31/2014; 289(44): 30190-5. PMID: 25202011, PMCID: PMC4215201, PII: C114.598946, DOI: 10.1074/jbc.C114.598946, ISSN: 1083-351X.

Wu L, Parekh VV, Hsiao J, Kitamura D, Van Kaer L. Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2014 Oct 10/28/2014; 111(43): E4638-47. PMID: 25313053, PMCID: PMC4217427, PII: 1324052111, DOI: 10.1073/pnas.1324052111, ISSN: 1091-6490.

Van Kaer L, Algood HM, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D. CD8aa¿ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Immunity [print-electronic]. 2014 Sep 9/18/2014; 41(3): 451-64. PMID: 25220211, PMCID: PMC4169715, PII: S1074-7613(14)00304-5, DOI: 10.1016/j.immuni.2014.08.010, ISSN: 1097-4180.

Bhattacharya D, Dwivedi VP, Maiga M, Maiga M, Van Kaer L, Bishai WR, Das G. Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis. J. Biol. Chem [print-electronic]. 2014 Jun 6/6/2014; 289(23): 16508-15. PMID: 24711459, PMCID: PMC4047417, PII: M114.558098, DOI: 10.1074/jbc.M114.558098, ISSN: 1083-351X.

Bag P, Ojha D, Mukherjee H, Halder UC, Mondal S, Biswas A, Sharon A, Van Kaer L, Chakrabarty S, Das G, Mitra D, Chattopadhyay D. A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events. Antiviral Res [print-electronic]. 2014 May; 105: 126-34. PMID: 24576908, PII: S0166-3542(14)00050-3, DOI: 10.1016/j.antiviral.2014.02.007, ISSN: 1872-9096.

Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dubé PE, Wilson KT, Ren X, Hao X, Polk DB, Yan F. Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. J Immunol [print-electronic]. 2014 Feb 2/1/2014; 192(3): 1013-23. PMID: 24391216, PMCID: PMC4006992, PII: jimmunol.1300133, DOI: 10.4049/jimmunol.1300133, ISSN: 1550-6606.

Kanaseki T, Lind KC, Escobar H, Nagarajan N, Reyes-Vargas E, Rudd B, Rockwood AL, Van Kaer L, Sato N, Delgado JC, Shastri N. ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides. J Immunol [print-electronic]. 2013 Aug 8/15/2013; 191(4): 1547-55. PMID: 23863903, PMCID: PMC3735839, PII: jimmunol.1301043, DOI: 10.4049/jimmunol.1301043, ISSN: 1550-6606.

Parekh VV, Wu L, Boyd KL, Williams JA, Gaddy JA, Olivares-Villagómez D, Cover TL, Zong WX, Zhang J, Van Kaer L. Impaired autophagy, defective T cell homeostasis, and a wasting syndrome in mice with a T cell-specific deletion of Vps34. J. Immunol [print-electronic]. 2013 May 5/15/2013; 190(10): 5086-101. PMID: 23596309, PMCID: PMC3646937, PII: jimmunol.1202071, DOI: 10.4049/jimmunol.1202071, ISSN: 1550-6606.

Spencer CT, Dragovic SM, Conant SB, Gray JJ, Zheng M, Samir P, Niu X, Moutaftsi M, Van Kaer L, Sette A, Link AJ, Joyce S. Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Eur. J. Immunol [print-electronic]. 2013 May; 43(5): 1162-72. PMID: 23386199, PMCID: PMC3798073, DOI: 10.1002/eji.201243087, ISSN: 1521-4141.

Andoh Y, Ogura H, Satoh M, Shimano K, Okuno H, Fujii S, Ishimori N, Eshima K, Tamauchi H, Otani T, Nakai Y, Van Kaer L, Tsutsui H, Onoé K, Iwabuchi K. Natural killer T cells are required for lipopolysaccharide-mediated enhancement of atherosclerosis in apolipoprotein E-deficient mice. Immunobiology [print-electronic]. 2013 Apr; 218(4): 561-9. PMID: 22954709, PMCID: PMC3535521, PII: S0171-2985(12)00186-6, DOI: 10.1016/j.imbio.2012.07.022, ISSN: 1878-3279.

Parekh VV, Wu L, Olivares-Villagómez D, Wilson KT, Van Kaer L. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. J. Immunol [print-electronic]. 2013 Mar 3/1/2013; 190(5): 1948-60. PMID: 23345328, PMCID: PMC3577977, PII: jimmunol.1201718, DOI: 10.4049/jimmunol.1201718, ISSN: 1550-6606.

Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J. Immunol [print-electronic]. 2013 Feb 2/15/2013; 190(4): 1849-58. PMID: 23303670, PMCID: PMC3563924, PII: jimmunol.1201373, DOI: 10.4049/jimmunol.1201373, ISSN: 1550-6606.

Van Kaer L, Parekh VV, Wu L. Invariant natural killer T cells as sensors and managers of inflammation. Trends Immunol [print-electronic]. 2013 Feb; 34(2): 50-8. PMID: 23017731, PMCID: PMC3615427, PII: S1471-4906(12)00147-0, DOI: 10.1016/, ISSN: 1471-4981.

Van Kaer L, Rabacal WA, Scott Algood HM, Parekh VV, Olivares-Villagómez D. In vitro induction of regulatory CD4+CD8a+ T cells by TGF-ß, IL-7 and IFN-¿. PLoS ONE [electronic-print]. 2013; 8(7): e67821. PMID: 23844100, PMCID: PMC3701067, PII: PONE-D-13-11341, DOI: 10.1371/journal.pone.0067821, ISSN: 1932-6203.

Wu L, Van Kaer L. Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance. Adipocyte. 2013 Jan 1/1/2013; 2(1): 12-6. PMID: 23700548, PMCID: PMC3661135, PII: 2012ADIPOCYTE064R, DOI: 10.4161/adip.22296, ISSN: 2162-3945.

Wu W, Shi S, Ljunggren HG, Cava AL, Van Kaer L, Shi FD, Liu R. NK cells inhibit T-bet-deficient, autoreactive Th17 cells. Scand J Immunol. 2012 Dec; 76(6): 559-66. PMID: 22928727, PMCID: PMC3600979, DOI: 10.1111/j.1365-3083.2012.02773.x, ISSN: 1365-3083.

Wu L, Parekh VV, Gabriel CL, Bracy DP, Marks-Shulman PA, Tamboli RA, Kim S, Mendez-Fernandez YV, Besra GS, Lomenick JP, Williams B, Wasserman DH, Van Kaer L. Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2012 May 5/8/2012; 109(19): E1143-52. PMID: 22493234, PMCID: PMC3358828, PII: 1200498109, DOI: 10.1073/pnas.1200498109, ISSN: 1091-6490.

Gordy LE, Bezbradica JS, Flyak AI, Spencer CT, Dunkle A, Sun J, Stanic AK, Boothby MR, He YW, Zhao Z, Van Kaer L, Joyce S. IL-15 regulates homeostasis and terminal maturation of NKT cells. J. Immunol [print-electronic]. 2011 Dec 12/15/2011; 187(12): 6335-45. PMID: 22084435, PMCID: PMC3237743, PII: jimmunol.1003965, DOI: 10.4049/jimmunol.1003965, ISSN: 1550-6606.

Oeser JK, Parekh VV, Wang Y, Jegadeesh NK, Sarkar SA, Wong R, Lee CE, Pound LD, Hutton JC, Van Kaer L, O'Brien RM. Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice. Diabetes [print-electronic]. 2011 Nov; 60(11): 2922-7. PMID: 21896930, PMCID: PMC3198073, PII: db11-0220, DOI: 10.2337/db11-0220, ISSN: 1939-327X.

Olivares-Villagómez D, Algood HM, Singh K, Parekh VV, Ryan KE, Piazuelo MB, Wilson KT, Van Kaer L. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. J. Immunol [print-electronic]. 2011 Oct 10/15/2011; 187(8): 4051-60. PMID: 21900182, PMCID: PMC3186831, PII: jimmunol.1101052, DOI: 10.4049/jimmunol.1101052, ISSN: 1550-6606.

Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H. Mucosal memory CD8¿ T cells are selected in the periphery by an MHC class I molecule. Nat Immunol. 2011 Oct 10/2/2011; 12(11): 1086-95. PMID: 21964609, PMCID: PMC3197978, PII: ni.2106, DOI: 10.1038/ni.2106, ISSN: 1529-2916.

Shi FD, Ljunggren HG, La Cava A, Van Kaer L. Organ-specific features of natural killer cells. Nat Rev Immunol. 2011 Sep 9/23/2011; 11(10): 658-71. PMID: 21941294, PMCID: PMC3620656, PII: nri3065, DOI: 10.1038/nri3065, ISSN: 1474-1741.

Dragovic SM, Hill T, Christianson GJ, Kim S, Elliott T, Scott D, Roopenian DC, Van Kaer L, Joyce S. Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens. J. Immunol [print-electronic]. 2011 Jun 6/15/2011; 186(12): 6683-92. PMID: 21572029, PMCID: PMC3537507, PII: jimmunol.1100525, DOI: 10.4049/jimmunol.1100525, ISSN: 1550-6606.

Hao J, Campagnolo D, Liu R, Piao W, Shi S, Hu B, Xiang R, Zhou Q, Vollmer T, Van Kaer L, La Cava A, Shi FD. Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation. Ann Neurol [print-electronic]. 2011 Apr; 69(4): 721-34. PMID: 21425186, PMCID: PMC3082615, DOI: 10.1002/ana.22339, ISSN: 1531-8249.

Mannik LA, Chin-Yee I, Sharif S, Van Kaer L, Delovitch TL, Haeryfar SM. Engagement of glycosylphosphatidylinositol-anchored proteins results in enhanced mouse and human invariant natural killer T cell responses. Immunology [print-electronic]. 2011 Mar; 132(3): 361-75. PMID: 21070234, PMCID: PMC3044902, DOI: 10.1111/j.1365-2567.2010.03369.x, ISSN: 1365-2567.

van den Heuvel MJ, Garg N, Van Kaer L, Haeryfar SM. NKT cell costimulation: experimental progress and therapeutic promise. Trends Mol Med [print-electronic]. 2011 Feb; 17(2): 65-77. PMID: 21087900, PMCID: PMC3616392, PII: S1471-4914(10)00161-9, DOI: 10.1016/j.molmed.2010.10.007, ISSN: 1471-499X.

Van Kaer L, Parekh VV, Wu L. Invariant natural killer T cells: bridging innate and adaptive immunity. Cell Tissue Res [print-electronic]. 2011 Jan; 343(1): 43-55. PMID: 20734065, PMCID: PMC3616393, DOI: 10.1007/s00441-010-1023-3, ISSN: 1432-0878.

Wu L, Van Kaer L. Natural killer T cells in health and disease. Front Biosci (Schol Ed). 2011; 3: 236-51. PMID: 21196373, PMCID: PMC3626278, PII: 148, ISSN: 1945-0524.

Van Kaer L, Parekh VV, Wu L. Invariant NK T cells: potential for immunotherapeutic targeting with glycolipid antigens. Immunotherapy. 2011 Jan; 3(1): 59-75. PMID: 21174558, DOI: 10.2217/imt.10.85, ISSN: 1750-7448.

Van Kaer L. Glatiramer acetate for treatment of MS: regulatory B cells join the cast of players. Exp. Neurol [print-electronic]. 2011 Jan; 227(1): 19-23. PMID: 20969865, PMCID: PMC3018666, PII: S0014-4886(10)00394-8, DOI: 10.1016/j.expneurol.2010.10.009, ISSN: 1090-2430.

Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-¿ production. Gastroenterology [print-electronic]. 2011 Jan; 140(1): 265-74. PMID: 20875416, PMCID: PMC3008308, PII: S0016-5085(10)01421-6, DOI: 10.1053/j.gastro.2010.09.041, ISSN: 1528-0012.

Olivares-Villagómez D, Van Kaer L. TL and CD8aa: Enigmatic partners in mucosal immunity. Immunol. Lett [print-electronic]. 2010 Nov 11/30/2010; 134(1): 1-6. PMID: 20850477, PMCID: PMC2967663, PII: S0165-2478(10)00224-5, DOI: 10.1016/j.imlet.2010.09.004, ISSN: 1879-0542.

Van Kaer L. Comeback kids: CD8(+) suppressor T cells are back in the game. J. Clin. Invest [print-electronic]. 2010 Oct; 120(10): 3432-4. PMID: 20877006, PMCID: PMC2947243, PII: 44395, DOI: 10.1172/JCI44395, ISSN: 1558-8238.

Braun NA, Mendez-Fernandez YV, Covarrubias R, Porcelli SA, Savage PB, Yagita H, Van Kaer L, Major AS. Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2010 Sep; 30(9): 1758-65. PMID: 20539017, PMCID: PMC2963029, PII: ATVBAHA.110.206045, DOI: 10.1161/ATVBAHA.110.206045, ISSN: 1524-4636.

Hao J, Liu R, Piao W, Zhou Q, Vollmer TL, Campagnolo DI, Xiang R, La Cava A, Van Kaer L, Shi FD. Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology. J. Exp. Med [print-electronic]. 2010 Aug 8/30/2010; 207(9): 1907-21. PMID: 20696699, PMCID: PMC2931174, PII: jem.20092749, DOI: 10.1084/jem.20092749, ISSN: 1540-9538.

Van Kaer L, Joyce S. The hunt for iNKT cell antigens: alpha-galactosidase-deficient mice to the rescue?. Immunity. 2010 Aug 8/27/2010; 33(2): 143-5. PMID: 20732635, PII: S1074-7613(10)00292-X, DOI: 10.1016/j.immuni.2010.08.009, ISSN: 1097-4180.

Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E. Follicular B cell trafficking within the spleen actively restricts humoral immune responses. Immunity [print-electronic]. 2010 Aug 8/27/2010; 33(2): 254-65. PMID: 20691614, PMCID: PMC2929658, PII: S1074-7613(10)00281-5, DOI: 10.1016/j.immuni.2010.07.016, ISSN: 1097-4180.

Zu L, Bedja D, Fox-Talbot K, Gabrielson KL, Van Kaer L, Becker LC, Cai ZP. Evidence for a role of immunoproteasomes in regulating cardiac muscle mass in diabetic mice. J. Mol. Cell. Cardiol [print-electronic]. 2010 Jul; 49(1): 5-15. PMID: 20153750, PMCID: PMC2883685, PII: S0022-2828(10)00042-8, DOI: 10.1016/j.yjmcc.2010.02.007, ISSN: 1095-8584.

Liu R, Zhou Q, La Cava A, Campagnolo DI, Van Kaer L, Shi FD. Expansion of regulatory T cells via IL-2/anti-IL-2 mAb complexes suppresses experimental myasthenia. Eur. J. Immunol. 2010 Jun; 40(6): 1577-89. PMID: 20352624, PMCID: PMC3600978, DOI: 10.1002/eji.200939792, ISSN: 1521-4141.

Das J, Ren G, Zhang L, Roberts AI, Zhao X, Bothwell AL, Van Kaer L, Shi Y, Das G. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J. Exp. Med [print-electronic]. 2009 Oct 10/26/2009; 206(11): 2407-16. PMID: 19808254, PMCID: PMC2768861, PII: jem.20082286, DOI: 10.1084/jem.20082286, ISSN: 1540-9538.

Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection. J. Immunol [print-electronic]. 2009 Aug 8/1/2009; 183(3): 2016-26. PMID: 19587017, PMCID: PMC3755459, PII: jimmunol.0803167, DOI: 10.4049/jimmunol.0803167, ISSN: 1550-6606.

Wu L, Gabriel CL, Parekh VV, Van Kaer L. Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities. Tissue Antigens [print-electronic]. 2009 Jun; 73(6): 535-45. PMID: 19392798, PII: TAN1256, DOI: 10.1111/j.1399-0039.2009.01256.x, ISSN: 1399-0039.

Moens L, Jeurissen A, Nierkens S, Boon L, Van Kaer L, Kasran A, Wuyts G, Ceuppens JL, Bossuyt X. Generation of antibody responses to pneumococcal capsular polysaccharides is independent of CD1 expression in mice. Infect. Immun [print-electronic]. 2009 May; 77(5): 1976-80. PMID: 19188354, PMCID: PMC2681747, PII: IAI.01091-08, DOI: 10.1128/IAI.01091-08, ISSN: 1098-5522.

Parekh VV, Lalani S, Kim S, Halder R, Azuma M, Yagita H, Kumar V, Wu L, Kaer LV. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J. Immunol. 2009 Mar 3/1/2009; 182(5): 2816-26. PMID: 19234176, PMCID: PMC2709814, PII: 182/5/2816, DOI: 10.4049/jimmunol.0803648, ISSN: 1550-6606.

Wu L, Van Kaer L. Natural killer T cells and autoimmune disease. Curr. Mol. Med. 2009 Feb; 9(1): 4-14. PMID: 19199937, ISSN: 1566-5240.

Sadagopal S, Braunstein M, Hager CC, Wei J, Daniel AK, Bochan MR, Crozier I, Smith NE, Gates HO, Barnett L, Van Kaer L, Price JO, Blackwell TS, Kalams SA, Kernodle DS. Reducing the activity and secretion of microbial antioxidants enhances the immunogenicity of BCG. PLoS ONE [print-electronic]. 2009; 4(5): e5531. PMID: 19436730, PMCID: PMC2677452, DOI: 10.1371/journal.pone.0005531, ISSN: 1932-6203.

Kim S, Lalani S, Parekh VV, Wu L, Van Kaer L. Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines. 2008 Dec; 7(10): 1519-32. PMID: 19053208, PMCID: PMC2680388, DOI: 10.1586/14760584.7.10.1519, ISSN: 1744-8395.

Cai ZP, Shen Z, Van Kaer L, Becker LC. Ischemic preconditioning-induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. FASEB J [print-electronic]. 2008 Dec; 22(12): 4248-57. PMID: 18728217, PMCID: PMC2614607, PII: fj.08-105940, DOI: 10.1096/fj.08-105940, ISSN: 1530-6860.

Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L. Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Nov 11/18/2008; 105(46): 17931-6. PMID: 19004778, PMCID: PMC2584730, PII: 0808242105, DOI: 10.1073/pnas.0808242105, ISSN: 1091-6490.

Diao H, Iwabuchi K, Li L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T. Osteopontin regulates development and function of invariant natural killer T cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Oct 10/14/2008; 105(41): 15884-9. PMID: 18836077, PMCID: PMC2560993, PII: 0806089105, DOI: 10.1073/pnas.0806089105, ISSN: 1091-6490.

Adeeku E, Gudapati P, Mendez-Fernandez Y, Van Kaer L, Boothby M. Flexibility accompanies commitment of memory CD4 lymphocytes derived from IL-4 locus-activated precursors. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Jul 7/8/2008; 105(27): 9307-12. PMID: 18591677, PMCID: PMC2453725, PII: 0704807105, DOI: 10.1073/pnas.0704807105, ISSN: 1091-6490.

Ni CY, Wu ZH, Florence WC, Parekh VV, Arrate MP, Pierce S, Schweitzer B, Van Kaer L, Joyce S, Miyamoto S, Ballard DW, Oltz EM. Cutting edge: K63-linked polyubiquitination of NEMO modulates TLR signaling and inflammation in vivo. J. Immunol. 2008 Jun 6/1/2008; 180(11): 7107-11. PMID: 18490708, PMCID: PMC2601684, PII: 180/11/7107, ISSN: 0022-1767.

Kim S, Lalani S, Parekh VV, Vincent TL, Wu L, Van Kaer L. Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J. Clin. Invest. 2008 Jun; 118(6): 2301-15. PMID: 18451996, PMCID: PMC2350429, DOI: 10.1172/JCI33071, ISSN: 0021-9738.

Joyce S, Van Kaer L. Lung NKT cell commotion takes your breath away. Nature medicine. 2008 Jun; 14(6) Sect. 609,10.

Joyce S, Van Kaer L. Invariant natural killer T cells trigger adaptive lymphocytes to churn up bile. Cell Host Microbe. 2008 May 5/15/2008; 3(5): 275-7. PMID: 18474352, PII: S1931-3128(08)00125-X, DOI: 10.1016/j.chom.2008.04.007, ISSN: 1934-6069.

Yamaura A, Hotta C, Nakazawa M, Van Kaer L, Minami M. Human invariant Valpha24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells. Blood [print-electronic]. 2008 Apr 4/15/2008; 111(8): 4254-63. PMID: 18270329, PII: S0006-4971(20)40888-2, DOI: 10.1182/blood-2007-04-085142, ISSN: 0006-4971.

Van Kaer L. Pillars article: antigen presentation: discovery of the peptide TAP. J. Immunol. 2008 Mar 3/1/2008; 180(5): 2723-4. PMID: 18292486, PII: 180/5/2723, ISSN: 0022-1767.

Miyazaki Y, Iwabuchi K, Iwata D, Miyazaki A, Kon Y, Niino M, Kikuchi S, Yanagawa Y, Kaer LV, Sasaki H, Onoé K. Effect of high fat diet on NKT cell function and NKT cell-mediated regulation of Th1 responses. Scand J Immunol [print-electronic]. 2008 Mar; 67(3): 230-7. PMID: 18226013, PII: SJI2062, DOI: 10.1111/j.1365-3083.2007.02062.x, ISSN: 1365-3083.

Matsumoto Y, Yuki N, Van Kaer L, Furukawa K, Hirata K, Sugita M. Cutting edge: Guillain-Barre syndrome-associated IgG responses to gangliosides are generated independently of CD1 function in mice. J Immunol. 2008 Jan 1/1/2008; 180(1): 39-43. PMID: 18097001, PII: 180/1/39, DOI: 10.4049/jimmunol.180.1.39, ISSN: 0022-1767.

Wu L, Van Kaer L. Role of NKT cells in the digestive system. II. NKT cells and diabetes. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2007 Nov; 293(5): G919-22. PMID: 17600041, PII: 00242.2007, DOI: 10.1152/ajpgi.00242.2007, ISSN: 0193-1857.

Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonça-Previato L, Nobrega A, Bellio M. Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J. Leukoc. Biol [print-electronic]. 2007 Sep; 82(3): 488-96. PMID: 17540734, PII: jlb.0706478, DOI: 10.1189/jlb.0706478, ISSN: 0741-5400.

Puttaparthi K, Van Kaer L, Elliott JL. Assessing the role of immuno-proteasomes in a mouse model of familial ALS. Exp. Neurol [print-electronic]. 2007 Jul; 206(1): 53-8. PMID: 17482163, PMCID: PMC2692686, PII: S0014-4886(07)00135-5, DOI: 10.1016/j.expneurol.2007.03.024, ISSN: 0014-4886.

Van Kaer L. NKT cells: T lymphocytes with innate effector functions. Curr. Opin. Immunol [print-electronic]. 2007 Jun; 19(3): 354-64. PMID: 17428648, PII: S0952-7915(07)00052-0, DOI: 10.1016/j.coi.2007.03.001, ISSN: 0952-7915.

Yang JQ, Wen X, Liu H, Folayan G, Dong X, Zhou M, Van Kaer L, Singh RR. Examining the role of CD1d and natural killer T cells in the development of nephritis in a genetically susceptible lupus model. Arthritis Rheum. 2007 Apr; 56(4): 1219-33. PMID: 17393451, PMCID: PMC2291538, DOI: 10.1002/art.22490, ISSN: 0004-3591.

Parekh VV, Lalani S, Van Kaer L. The in vivo response of invariant natural killer T cells to glycolipid antigens. Int. Rev. Immunol. 2007 Jan; 26(1-2): 31-48. PMID: 17454263, PII: 776080054, DOI: 10.1080/08830180601070179, ISSN: 0883-0185.

Das J, Eynott P, Jupp R, Bothwell A, Van Kaer L, Shi Y, Das G. Natural killer T cells and CD8+ T cells are dispensable for T cell-dependent allergic airway inflammation [letter]. Nat. Med. 2006 Dec; 12(12): 1345-6; author reply 1347. PMID: 17151684, PII: nm1206-1345, DOI: 10.1038/nm1206-1345, ISSN: 1078-8956.

Das G, Das J, Eynott P, Zhang Y, Bothwell AL, Van Kaer L, Shi Y. Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J. Exp. Med [print-electronic]. 2006 Nov 11/27/2006; 203(12): 2603-11. PMID: 17088432, PMCID: PMC2118151, PII: jem.20060936, DOI: 10.1084/jem.20060936, ISSN: 0022-1007.

Takagi D, Iwabuchi K, Maeda M, Nakamaru Y, Furuta Y, Fukuda S, Van Kaer L, Nishihira J, Onoé K. Natural killer T cells ameliorate antibody-induced arthritis in macrophage migration inhibitory factor transgenic mice. Int. J. Mol. Med. 2006 Nov; 18(5): 829-36. PMID: 17016612, ISSN: 1107-3756.

Shi FD, Van Kaer L. Reciprocal regulation between natural killer cells and autoreactive T cells. Nat. Rev. Immunol. 2006 Oct; 6(10): 751-60. PMID: 16998508, PII: nri1935, DOI: 10.1038/nri1935, ISSN: 1474-1733.

Bezbradica JS, Gordy LE, Stanic AK, Dragovic S, Hill T, Hawiger J, Unutmaz D, Van Kaer L, Joyce S. Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny. Immunity [print-electronic]. 2006 Sep; 25(3): 487-97. PMID: 16949316, PII: S1074-7613(06)00376-1, DOI: 10.1016/j.immuni.2006.06.017, ISSN: 1074-7613.

Van Kaer L. Role of invariant natural killer T cells in immune regulation and as potential therapeutic targets in autoimmune disease. Expert Rev Clin Immunol. 2006 Sep; 2(5): 745-57. PMID: 20477630, DOI: 10.1586/1744666X.2.5.745, ISSN: 1744-8409.

Van Kaer L, Joyce S. Viral evasion of antigen presentation: not just for peptides anymore. Nature immunology. 2006 Aug; 7(8) Sect. 795,7.

La Cava A, Van Kaer L, Fu-Dong-Shi. CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol [print-electronic]. 2006 Jul; 27(7): 322-7. PMID: 16735139, PII: S1471-4906(06)00145-1, DOI: 10.1016/, ISSN: 1471-4906.

Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Van Kaer L, Brutkiewicz RR. Inhibition of antitumor immunity by invariant natural killer T cells in a T-cell lymphoma model in vivo. Int. J. Cancer. 2006 Jun 6/15/2006; 118(12): 3045-53. PMID: 16395717, DOI: 10.1002/ijc.21764, ISSN: 0020-7136.

Major AS, Joyce S, Van Kaer L. Lipid metabolism, atherogenesis and CD1-restricted antigen presentation. Trends Mol Med [print-electronic]. 2006 Jun; 12(6): 270-8. PMID: 16651026, PII: S1471-4914(06)00071-2, DOI: 10.1016/j.molmed.2006.04.004, ISSN: 1471-4914.

Liu R, Van Kaer L, La Cava A, Price M, Campagnolo DI, Collins M, Young DA, Vollmer TL, Shi FD. Autoreactive T cells mediate NK cell degeneration in autoimmune disease. J. Immunol. 2006 May 5/1/2006; 176(9): 5247-54. PMID: 16621990, PII: 176/9/5247, ISSN: 0022-1767.

Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagómez D, Dragovic S, Hill T, Roopenian DC, Joyce S, Van Kaer L. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J. Exp. Med [print-electronic]. 2006 Mar 3/20/2006; 203(3): 647-59. PMID: 16505142, PMCID: PMC2118255, PII: jem.20052271, DOI: 10.1084/jem.20052271, ISSN: 0022-1007.

Eger KA, Sundrud MS, Motsinger AA, Tseng M, Van Kaer L, Unutmaz D. Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions. PLoS ONE. 2006; 1: e50. PMID: 17183680, PMCID: PMC1762372, DOI: 10.1371/journal.pone.0000050, ISSN: 1932-6203.

Major AS, Singh RR, Joyce S, Van Kaer L. The role of invariant natural killer T cells in lupus and atherogenesis. Immunol. Res. 2006; 34(1): 49-66. PMID: 16720898, PMCID: PMC2291524, PII: IR:34:1:49, ISSN: 0257-277X.

Liu R, La Cava A, Bai XF, Jee Y, Price M, Campagnolo DI, Christadoss P, Vollmer TL, Van Kaer L, Shi FD. Cooperation of invariant NKT cells and CD4+CD25+ T regulatory cells in the prevention of autoimmune myasthenia. J. Immunol. 2005 Dec 12/15/2005; 175(12): 7898-904. PMID: 16339525, PII: 175/12/7898, ISSN: 0022-1767.

Beilke JN, Kuhl NR, Van Kaer L, Gill RG. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat. Med [print-electronic]. 2005 Oct; 11(10): 1059-65. PMID: 16155578, PII: nm1296, DOI: 10.1038/nm1296, ISSN: 1078-8956.

Parekh VV, Wilson MT, Olivares-Villagómez D, Singh AK, Wu L, Wang CR, Joyce S, Van Kaer L. Glycolipid antigen induces long-term natural killer T cell anergy in mice. J. Clin. Invest. 2005 Sep; 115(9): 2572-83. PMID: 16138194, PMCID: PMC1193878, DOI: 10.1172/JCI24762, ISSN: 0021-9738.

Chen M, Tabaczewski P, Truscott SM, Van Kaer L, Stroynowski I. Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathway. J. Immunol. 2005 Jul 7/15/2005; 175(2): 1047-55. PMID: 16002705, PII: 175/2/1047, ISSN: 0022-1767.

Van Kaer L, Joyce S. Innate immunity: NKT cells in the spotlight. Curr. Biol. 2005 Jun 6/7/2005; 15(11): R429-31. PMID: 15936267, PII: S0960-9822(05)00547-6, DOI: 10.1016/j.cub.2005.05.032, ISSN: 0960-9822.

Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. J. Immunol. 2005 Apr 4/15/2005; 174(8): 4696-705. PMID: 15814694, PII: 174/8/4696, ISSN: 0022-1767.

Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S. Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Apr 4/5/2005; 102(14): 5114-9. PMID: 15792999, PMCID: PMC555981, PII: 0408449102, DOI: 10.1073/pnas.0408449102, ISSN: 0027-8424.

Singh AK, Yang JQ, Parekh VV, Wei J, Wang CR, Joyce S, Singh RR, Van Kaer L. The natural killer T cell ligand alpha-galactosylceramide prevents or promotes pristane-induced lupus in mice. Eur. J. Immunol. 2005 Apr; 35(4): 1143-54. PMID: 15761849, PMCID: PMC2291523, DOI: 10.1002/eji.200425861, ISSN: 0014-2980.

Robbins SH, Tessmer MS, Van Kaer L, Brossay L. Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur. J. Immunol. 2005 Mar; 35(3): 757-65. PMID: 15719366, DOI: 10.1002/eji.200425797, ISSN: 0014-2980.

Van Kaer L. Alpha-Galactosylceramide therapy for autoimmune diseases: prospects and obstacles. Nat. Rev. Immunol. 2005 Jan; 5(1): 31-42. PMID: 15630427, PII: nri1531, DOI: 10.1038/nri1531, ISSN: 1474-1733.

Hashimoto D, Asakura S, Miyake S, Yamamura T, Van Kaer L, Liu C, Tanimoto M, Teshima T. Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells. J. Immunol. 2005 Jan 1/1/2005; 174(1): 551-6. PMID: 15611282, PII: 174/1/551, ISSN: 0022-1767.

Parekh VV, Wilson MT, Van Kaer L. INKT-cell responses to glycolipids. Crit. Rev. Immunol. 2005; 25(3): 183-213. PMID: 16048435, PII: 2a1e865d14be9dc2,64f376715f2cfa97, ISSN: 1040-8401.

Major AS, Wilson MT, McCaleb JL, Ru Su Y, Stanic AK, Joyce S, Van Kaer L, Fazio S, Linton MF. Quantitative and qualitative differences in proatherogenic NKT cells in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2004 Dec; 24(12): 2351-7. PMID: 15472130, PII: 01.ATV.0000147112.84168.87, DOI: 10.1161/01.ATV.0000147112.84168.87, ISSN: 1524-4636.

Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, Ito D, Segawa T, Maeda M, Hamuro J, Nakayama T, Taniguchi M, Yagita H, Van Kaer L, Onóe K, Denhardt D, Rittling S, Uede T. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity. 2004 Oct; 21(4): 539-50. PMID: 15485631, PII: S1074761304002481, DOI: 10.1016/j.immuni.2004.08.012, ISSN: 1074-7613.

Nakai Y, Iwabuchi K, Fujii S, Ishimori N, Dashtsoodol N, Watano K, Mishima T, Iwabuchi C, Tanaka S, Bezbradica JS, Nakayama T, Taniguchi M, Miyake S, Yamamura T, Kitabatake A, Joyce S, Van Kaer L, Onoé K. Natural killer T cells accelerate atherogenesis in mice. Blood [print-electronic]. 2004 Oct 10/1/2004; 104(7): 2051-9. PMID: 15113755, PII: 2003-10-3485, DOI: 10.1182/blood-2003-10-3485, ISSN: 0006-4971.

Li L, Sullivan BA, Aldrich CJ, Soloski MJ, Forman J, Grandea AG, Jensen PE, Van Kaer L. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J. Immunol. 2004 Sep 9/15/2004; 173(6): 3707-15. PMID: 15356116, PII: 173/6/3707, ISSN: 0022-1767.

Parekh VV, Singh AK, Wilson MT, Olivares-Villagómez D, Bezbradica JS, Inazawa H, Ehara H, Sakai T, Serizawa I, Wu L, Wang CR, Joyce S, Van Kaer L. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J. Immunol. 2004 Sep 9/15/2004; 173(6): 3693-706. PMID: 15356115, PII: 173/6/3693, ISSN: 0022-1767.

Van Kaer L. Natural killer T cells as targets for immunotherapy of autoimmune diseases. Immunol. Cell Biol. 2004 Jun; 82(3): 315-22. PMID: 15186263, PII: ICB1252, DOI: 10.1111/j.0818-9641.2004.01252.x, ISSN: 0818-9641.

Yang JQ, Chun T, Liu H, Hong S, Bui H, Van Kaer L, Wang CR, Singh RR. CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur. J. Immunol. 2004 Jun; 34(6): 1723-32. PMID: 15162443, PMCID: PMC2291526, DOI: 10.1002/eji.200324099, ISSN: 0014-2980.

Adachi K, Tsutsui H, Seki E, Nakano H, Takeda K, Okumura K, Van Kaer L, Nakanishi K. Contribution of CD1d-unrestricted hepatic DX5+ NKT cells to liver injury in Plasmodium berghei-parasitized erythrocyte-injected mice. Int. Immunol [print-electronic]. 2004 Jun; 16(6): 787-98. PMID: 15096477, PII: dxh080, DOI: 10.1093/intimm/dxh080, ISSN: 0953-8178.

Stanic AK, Bezbradica JS, Park JJ, Van Kaer L, Boothby MR, Joyce S. Cutting edge: the ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C theta and NF-kappa B. J. Immunol. 2004 Apr 4/15/2004; 172(8): 4667-71. PMID: 15067039, ISSN: 0022-1767.

Roberts TJ, Lin Y, Spence PM, Van Kaer L, Brutkiewicz RR. CD1d1-dependent control of the magnitude of an acute antiviral immune response. J. Immunol. 2004 Mar 3/15/2004; 172(6): 3454-61. PMID: 15004145, ISSN: 0022-1767.

Mühlen KA, Schümann J, Wittke F, Stenger S, Van Rooijen N, Van Kaer L, Tiegs G. NK cells, but not NKT cells, are involved in Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in mice. J. Immunol. 2004 Mar 3/1/2004; 172(5): 3034-41. PMID: 14978108, ISSN: 0022-1767.

Turnquist HR, Petersen JL, Vargas SE, McIlhaney MM, Bedows E, Mayer WE, Grandea AG, Van Kaer L, Solheim JC. The Ig-like domain of tapasin influences intermolecular interactions. J. Immunol. 2004 Mar 3/1/2004; 172(5): 2976-84. PMID: 14978101, ISSN: 0022-1767.

Godfrey DI, MacDonald HR, Kronenberg M, Smyth MJ, Van Kaer L. NKT cells: what's in a name?. Nat. Rev. Immunol. 2004 Mar; 4(3): 231-7. PMID: 15039760, PII: nri1309, DOI: 10.1038/nri1309, ISSN: 1474-1733.

Stanic AK, Bezbradica JS, Park JJ, Matsuki N, Mora AL, Van Kaer L, Boothby MR, Joyce S. NF-kappa B controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J. Immunol. 2004 Feb 2/15/2004; 172(4): 2265-73. PMID: 14764695, ISSN: 0022-1767.

Van Kaer L. Regulation of immune responses by CD1d-restricted natural killer T cells. Immunol. Res. 2004; 30(2): 139-53. PMID: 15477656, PII: IR:30:2:139, DOI: 10.1385/IR:30:2:139, ISSN: 0257-277X.

Zhang J, Dong M, Li L, Fan Y, Pathre P, Dong J, Lou D, Wells JM, Olivares-Villagómez D, Van Kaer L, Wang X, Xu M. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Dec 12/23/2003; 100(26): 15782-7. PMID: 14663139, PMCID: PMC307645, PII: 2636393100, DOI: 10.1073/pnas.2636393100, ISSN: 0027-8424.

Liang H, VanValkenburgh C, Chen X, Mullins C, Van Kaer L, Green N, Fang H. Genetic complementation in yeast reveals functional similarities between the catalytic subunits of mammalian signal peptidase complex. J. Biol. Chem [print-electronic]. 2003 Dec 12/19/2003; 278(51): 50932-9. PMID: 14559916, PII: M307542200, DOI: 10.1074/jbc.M307542200, ISSN: 0021-9258.

Zhang F, Liang Z, Matsuki N, Van Kaer L, Joyce S, Wakeland EK, Aune TM. A murine locus on chromosome 18 controls NKT cell homeostasis and Th cell differentiation. J. Immunol. 2003 Nov 11/1/2003; 171(9): 4613-20. PMID: 14568935, ISSN: 0022-1767.

Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia SS, Roopenian DC, Yamamura T, Joyce S. Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T(iNKT) cell receptor [corrected]. J. Immunol. 2003 Nov 11/1/2003; 171(9): 4539-51. PMID: 14568927, ISSN: 0022-1767.

Yang JQ, Saxena V, Xu H, Van Kaer L, Wang CR, Singh RR. Repeated alpha-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol. 2003 Oct 10/15/2003; 171(8): 4439-46. PMID: 14530371, ISSN: 0022-1767.

Wilson MT, Johansson C, Olivares-Villagómez D, Singh AK, Stanic AK, Wang CR, Joyce S, Wick MJ, Van Kaer L. The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Sep 9/16/2003; 100(19): 10913-8. PMID: 12960397, PMCID: PMC196902, PII: 1833166100, DOI: 10.1073/pnas.1833166100, ISSN: 0027-8424.

Yang JQ, Singh AK, Wilson MT, Satoh M, Stanic AK, Park JJ, Hong S, Gadola SD, Mizutani A, Kakumanu SR, Reeves WH, Cerundolo V, Joyce S, Van Kaer L, Singh RR. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J. Immunol. 2003 Aug 8/15/2003; 171(4): 2142-53. PMID: 12902521, ISSN: 0022-1767.

Shao H, Van Kaer L, Sun SL, Kaplan HJ, Sun D. Infiltration of the inflamed eye by NKT cells in a rat model of experimental autoimmune uveitis. J. Autoimmun. 2003 Aug; 21(1): 37-45. PMID: 12892734, PII: S0896841103000490, ISSN: 0896-8411.

Motsinger A, Azimzadeh A, Stanic AK, Johnson RP, Van Kaer L, Joyce S, Unutmaz D. Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells. J. Virol. 2003 Jul; 77(14): 8153-8. PMID: 12829854, PMCID: PMC161937, ISSN: 0022-538X.

Chefalo PJ, Grandea AG, Van Kaer L, Harding CV. Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH. J. Immunol. 2003 Jun 6/15/2003; 170(12): 5825-33. PMID: 12794107, ISSN: 0022-1767.

Matsuki N, Stanic AK, Embers ME, Van Kaer L, Morel L, Joyce S. Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. J. Immunol. 2003 Jun 6/1/2003; 170(11): 5429-37. PMID: 12759418, ISSN: 0022-1767.

Yoshimoto T, Min B, Sugimoto T, Hayashi N, Ishikawa Y, Sasaki Y, Hata H, Takeda K, Okumura K, Van Kaer L, Paul WE, Nakanishi K. Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. J. Exp. Med [print-electronic]. 2003 Apr 4/21/2003; 197(8): 997-1005. PMID: 12695491, PMCID: PMC2193873, PII: jem.20021701, DOI: 10.1084/jem.20021701, ISSN: 0022-1007.

Stanic AK, De Silva AD, Park JJ, Sriram V, Ichikawa S, Hirabyashi Y, Hayakawa K, Van Kaer L, Brutkiewicz RR, Joyce S. Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by beta-D-glucosylceramide synthase deficiency. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Feb 2/18/2003; 100(4): 1849-54. PMID: 12576547, PMCID: PMC149922, PII: 0430327100, DOI: 10.1073/pnas.0430327100, ISSN: 0027-8424.

Joyce S, Van Kaer L. CD1-restricted antigen presentation: an oily matter. Curr. Opin. Immunol. 2003 Feb; 15(1): 95-104. PMID: 12495740, PII: S0952791502000122, ISSN: 0952-7915.

Wilson MT, Van Kaer L. Natural killer T cells as targets for therapeutic intervention in autoimmune diseases. Curr. Pharm. Des. 2003; 9(3): 201-20. PMID: 12570826, ISSN: 1381-6128.

Yang, J.-Q., Saxena, V., Xu, H., Van Kaer, L., Wang, C.-R., and Singh, R.R. Repeated -galactosylceramide administration results in expansion of NKT cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol. 2003; 171: 4439-46.

Hayakawa Y, Takeda K, Yagita H, Smyth MJ, Van Kaer L, Okumura K, Saiki I. IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide. Blood. 2002 Sep 9/1/2002; 100(5): 1728-33. PMID: 12176894, ISSN: 0006-4971.

Faveeuw C, Angeli V, Fontaine J, Maliszewski C, Capron A, Van Kaer L, Moser M, Capron M, Trottein F. Antigen presentation by CD1d contributes to the amplification of Th2 responses to Schistosoma mansoni glycoconjugates in mice. J. Immunol. 2002 Jul 7/15/2002; 169(2): 906-12. PMID: 12097395, ISSN: 0022-1767.

Van Kaer L. Major histocompatibility complex class I-restricted antigen processing and presentation. Tissue Antigens. 2002 Jul; 60(1): 1-9. PMID: 12366777, PII: tan600101, ISSN: 0001-2815.

Mars LT, Laloux V, Goude K, Desbois S, Saoudi A, Van Kaer L, Lassmann H, Herbelin A, Lehuen A, Liblau RS. Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice. J. Immunol. 2002 Jun 6/15/2002; 168(12): 6007-11. PMID: 12055208, ISSN: 0022-1767.

Suárez IM, Benvenutti LA, Noronh I, Van Kaer L, Kalil J, Coelho V. Rejection of grafts with no H-2 disparity in TAP1 mutant mice: CD4 T cells are important effector cells and self H-2b class I molecules are target. Transpl. Immunol. 2002 May; 9(2-4): 101-10. PMID: 12180815, ISSN: 0966-3274.

Wilson MT, Singh AK, Van Kaer L. Immunotherapy with ligands of natural killer T cells. Trends Mol Med. 2002 May; 8(5): 225-31. PMID: 12067632, PII: S1471491402023250, ISSN: 1471-4914.

Johnson TR, Hong S, Van Kaer L, Koezuka Y, Graham BS. NK T cells contribute to expansion of CD8(+) T cells and amplification of antiviral immune responses to respiratory syncytial virus. J. Virol. 2002 May; 76(9): 4294-303. PMID: 11932395, PMCID: PMC155085, ISSN: 0022-538X.

Tompkins SM, Padilla J, Dal Canto MC, Ting JP, Van Kaer L, Miller SD. De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis. J. Immunol. 2002 Apr 4/15/2002; 168(8): 4173-83. PMID: 11937578, ISSN: 0022-1767.

Motsinger A, Haas DW, Stanic AK, Van Kaer L, Joyce S, Unutmaz D. CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J. Exp. Med. 2002 Apr 4/1/2002; 195(7): 869-79. PMID: 11927631, PMCID: PMC2193731, ISSN: 0022-1007.

Gonzalez-Aseguinolaza G, Van Kaer L, Bergmann CC, Wilson JM, Schmieg J, Kronenberg M, Nakayama T, Taniguchi M, Koezuka Y, Tsuji M. Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines. J. Exp. Med. 2002 Mar 3/4/2002; 195(5): 617-24. PMID: 11877484, PMCID: PMC2193764, ISSN: 0022-1007.

Mempel M, Ronet C, Suarez F, Gilleron M, Puzo G, Van Kaer L, Lehuen A, Kourilsky P, Gachelin G. Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells. J. Immunol. 2002 Jan 1/1/2002; 168(1): 365-71. PMID: 11751982, ISSN: 0022-1767.

Singh AK, Wilson MT, Hong S, Olivares-Villagómez D, Du C, Stanic AK, Joyce S, Sriram S, Koezuka Y, Van Kaer L. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 2001 Dec 12/17/2001; 194(12): 1801-11. PMID: 11748281, PMCID: PMC2193577, ISSN: 0022-1007.

Adachi K, Tsutsui H, Kashiwamura S, Seki E, Nakano H, Takeuchi O, Takeda K, Okumura K, Van Kaer L, Okamura H, Akira S, Nakanishi K. Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism. J. Immunol. 2001 Nov 11/15/2001; 167(10): 5928-34. PMID: 11698470, ISSN: 0022-1767.

Van Kaer L. Drugs from the sea: a marine sponge-derived compound prevents Type 1 diabetes. ScientificWorldJournal. 2001 Nov 11/6/2001; 1: 630-2. PMID: 12805764, DOI: 10.1100/tsw.2001.357, ISSN: 1537-744X.

Spence PM, Sriram V, Van Kaer L, Hobbs JA, Brutkiewicz RR. Generation of cellular immunity to lymphocytic choriomeningitis virus is independent of CD1d1 expression. Immunology. 2001 Oct; 104(2): 168-74. PMID: 11683957, PMCID: PMC1783302, PII: 1302, ISSN: 0019-2805.

Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV, Miura T, Haba T, Scherer DC, Wei J, Kronenberg M, Koezuka Y, Van Kaer L. The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 2001 Sep; 7(9): 1052-6. PMID: 11533710, PII: nm0901-1052, DOI: 10.1038/nm0901-1052, ISSN: 1078-8956.

Lybarger L, Yu YY, Chun T, Wang CR, Grandea AG, Van Kaer L, Hansen TH. Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers. J. Immunol. 2001 Aug 8/15/2001; 167(4): 2097-105. PMID: 11489993, ISSN: 0022-1767.

Chun T, Grandea AG, Lybarger L, Forman J, Van Kaer L, Wang CR. Functional roles of TAP and tapasin in the assembly of M3-N-formylated peptide complexes. J. Immunol. 2001 Aug 8/1/2001; 167(3): 1507-14. PMID: 11466371, ISSN: 0022-1767.

Hayakawa Y, Takeda K, Yagita H, Kakuta S, Iwakura Y, Van Kaer L, Saiki I, Okumura K. Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide. Eur. J. Immunol. 2001 Jun; 31(6): 1720-7. PMID: 11385616, PII: 10.1002/1521-4141(200106)31:6<1720::AID-IMMU1720>3.0.CO;2-U, ISSN: 0014-2980.

Hayakawa Y, Takeda K, Yagita H, Van Kaer L, Saiki I, Okumura K. Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J. Immunol. 2001 May 5/15/2001; 166(10): 6012-8. PMID: 11342617, ISSN: 0022-1767.

Grandea AG, Van Kaer L. Tapasin: an ER chaperone that controls MHC class I assembly with peptide. Trends Immunol. 2001 Apr; 22(4): 194-9. PMID: 11274924, PII: S1471-4906(01)01861-0, ISSN: 1471-4906.

Seino KI, Fukao K, Muramoto K, Yanagisawa K, Takada Y, Kakuta S, Iwakura Y, Van Kaer L, Takeda K, Nakayama T, Taniguchi M, Bashuda H, Yagita H, Okumura K. Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2001 Feb 2/27/2001; 98(5): 2577-81. PMID: 11226281, PMCID: PMC30180, PII: 041608298, DOI: 10.1073/pnas.041608298, ISSN: 0027-8424.

Leite-De-Moraes MC, Hameg A, Pacilio M, Koezuka Y, Taniguchi M, Van Kaer L, Schneider E, Dy M, Herbelin A. IL-18 enhances IL-4 production by ligand-activated NKT lymphocytes: a pro-Th2 effect of IL-18 exerted through NKT cells. J. Immunol. 2001 Jan 1/15/2001; 166(2): 945-51. PMID: 11145671, ISSN: 0022-1767.

Van Kaer L. Accessory proteins that control the assembly of MHC molecules with peptides. Immunol. Res. 2001; 23(2-3): 205-14. PMID: 11444385, PII: IR:23:2-3:205, DOI: 10.1385/IR:23:2-3:205, ISSN: 0257-277X.

Das G, Gould DS, Augustine MM, Fragoso G, Sciutto E, Stroynowski I, Van Kaer L, Schust DJ, Ploegh H, Janeway CA. Qa-2-dependent selection of CD8alpha/alpha T cell receptor alpha/beta(+) cells in murine intestinal intraepithelial lymphocytes. J. Exp. Med. 2000 Nov 11/20/2000; 192(10): 1521-8. PMID: 11085754, PMCID: PMC2193183, ISSN: 0022-1007.

Chen CL, Singh N, Yull FE, Strayhorn D, Van Kaer L, Kerr LD. Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function. J. Immunol. 2000 Nov 11/15/2000; 165(10): 5418-27. PMID: 11067893, ISSN: 0022-1767.

Assarsson E, Kambayashi T, Sandberg JK, Hong S, Taniguchi M, Van Kaer L, Ljunggren HG, Chambers BJ. CD8+ T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo. J. Immunol. 2000 Oct 10/1/2000; 165(7): 3673-9. PMID: 11034371, ISSN: 0022-1767.

Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG. Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat. Immunol. 2000 Sep; 1(3): 245-51. PMID: 10973283, DOI: 10.1038/79792, ISSN: 1529-2908.

Grandea AG, Golovina TN, Hamilton SE, Sriram V, Spies T, Brutkiewicz RR, Harty JT, Eisenlohr LC, Van Kaer L. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice. Immunity. 2000 Aug; 13(2): 213-22. PMID: 10981964, PII: S1074-7613(00)00021-2, ISSN: 1074-7613.

Kovalik JP, Singh N, Mendiratta SK, Martin WD, Ignatowicz L, Van Kaer L. The alloreactive and self-restricted CD4+ T cell response directed against a single MHC class II/peptide combination. J. Immunol. 2000 Aug 8/1/2000; 165(3): 1285-93. PMID: 10903728, PII: ji_v165n3p1285, ISSN: 0022-1767.

Gonzalez-Aseguinolaza G, de Oliveira C, Tomaska M, Hong S, Bruna-Romero O, Nakayama T, Taniguchi M, Bendelac A, Van Kaer L, Koezuka Y, Tsuji M. Alpha -galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria. Proc. Natl. Acad. Sci. U.S.A. 2000 Jul 7/18/2000; 97(15): 8461-6. PMID: 10900007, PMCID: PMC26970, PII: 97/15/8461, ISSN: 0027-8424.

Felix NJ, Brickey WJ, Griffiths R, Zhang J, Van Kaer L, Coffman T, Ting JP. H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. J. Exp. Med. 2000 Jul 7/3/2000; 192(1): 31-40. PMID: 10880524, PMCID: PMC1887714, ISSN: 0022-1007.

Osman Y, Kawamura T, Naito T, Takeda K, Van Kaer L, Okumura K, Abo T. Activation of hepatic NKT cells and subsequent liver injury following administration of alpha-galactosylceramide. Eur. J. Immunol. 2000 Jul; 30(7): 1919-28. PMID: 10940881, PII: 10.1002/1521-4141(200007)30:7<1919::AID-IMMU1919>3.0.CO;2-3, DOI: 10.1002/1521-4141(200007)30:7<1919::AID-IMMU1919>3.0.CO;2-3, ISSN: 0014-2980.

Nishimura T, Kitamura H, Iwakabe K, Yahata T, Ohta A, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, Taniguchi M, Nakui M, Sekimoto M, Koda T. The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int. Immunol. 2000 Jul; 12(7): 987-94. PMID: 10882410, ISSN: 0953-8178.

Takeda K, Hayakawa Y, Atsuta M, Hong S, Van Kaer L, Kobayashi K, Ito M, Yagita H, Okumura K. Relative contribution of NK and NKT cells to the anti-metastatic activities of IL-12. Int. Immunol. 2000 Jun; 12(6): 909-14. PMID: 10837418, ISSN: 0953-8178.

Takeda K, Hayakawa Y, Van Kaer L, Matsuda H, Yagita H, Okumura K. Critical contribution of liver natural killer T cells to a murine model of hepatitis. Proc. Natl. Acad. Sci. U.S.A. 2000 May 5/9/2000; 97(10): 5498-503. PMID: 10792025, PMCID: PMC25857, PII: 040566697, DOI: 10.1073/pnas.040566697, ISSN: 0027-8424.

Sousa AO, Mazzaccaro RJ, Russell RG, Lee FK, Turner OC, Hong S, Van Kaer L, Bloom BR. Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice. Proc. Natl. Acad. Sci. U.S.A. 2000 Apr 4/11/2000; 97(8): 4204-8. PMID: 10760288, PMCID: PMC18197, PII: 97/8/4204, ISSN: 0027-8424.

Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, Ruley HE. Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat. Genet. 2000 Feb; 24(2): 175-9. PMID: 10655065, DOI: 10.1038/72842, ISSN: 1061-4036.

Hong S, Van Kaer L. Immune privilege: keeping an eye on natural killer T cells. J. Exp. Med. 1999 Nov 11/1/1999; 190(9): 1197-200. PMID: 10544192, PMCID: PMC2195673, ISSN: 0022-1007.

Singh N, Van Kaer L. Unexpected reactivities of T cells selected by a single MHC-peptide ligand. J. Immunol. 1999 Oct 10/1/1999; 163(7): 3583-91. PMID: 10490950, PII: ji_v163n7p3583, ISSN: 0022-1767.

Singh N, Hong S, Scherer DC, Serizawa I, Burdin N, Kronenberg M, Koezuka Y, Van Kaer L. Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype. J. Immunol. 1999 Sep 9/1/1999; 163(5): 2373-7. PMID: 10452969, PII: ji_v163n5p2373, ISSN: 0022-1767.

Hameg A, Gouarin C, Gombert JM, Hong S, Van Kaer L, Bach JF, Herbelin A. IL-7 up-regulates IL-4 production by splenic NK1.1+ and NK1.1- MHC class I-like/CD1-dependent CD4+ T cells. J. Immunol. 1999 Jun 6/15/1999; 162(12): 7067-74. PMID: 10358149, ISSN: 0022-1767.

Hong S, Scherer DC, Singh N, Mendiratta SK, Serizawa I, Koezuka Y, Van Kaer L. Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice. Immunol. Rev. 1999 Jun; 169: 31-44. PMID: 10450506, ISSN: 0105-2896.

Kitamura H, Iwakabe K, Yahata T, Nishimura S, Ohta A, Ohmi Y, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, Taniguchi M, Nishimura T. The natural killer T (NKT) cell ligand alpha-galactosylceramide demonstrates its immunopotentiating effect by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells. J. Exp. Med. 1999 Apr 4/5/1999; 189(7): 1121-8. PMID: 10190903, PMCID: PMC2193012, ISSN: 0022-1007.

Mendiratta SK, Kovalik JP, Hong S, Singh N, Martin WD, Van Kaer L. Peptide dependency of alloreactive CD4+ T cell responses. Int. Immunol. 1999 Mar; 11(3): 351-60. PMID: 10221647, ISSN: 0953-8178.

Coelho V, Marrero I, Noronha I, Benvenuti LA, Van Kaer L, Kalil J. TAP1 mutant mice reject heart grafts from donors with no MHC disparity. Transplant. Proc. 1999 Feb; 31(1-2): 900-1. PMID: 10083397, PII: S0041-1345(98)01828-4, ISSN: 0041-1345.

Korsgren M, Persson CG, Sundler F, Bjerke T, Hansson T, Chambers BJ, Hong S, Van Kaer L, Ljunggren HG, Korsgren O. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice. J. Exp. Med. 1999 Feb 2/1/1999; 189(3): 553-62. PMID: 9927517, PMCID: PMC2192913, ISSN: 0022-1007.

Dabhi VM, Hovik R, Van Kaer L, Lindahl KF. The alloreactive T cell response against the class Ib molecule H2-M3 is specific for high affinity peptides. J. Immunol. 1998 Nov 11/15/1998; 161(10): 5171-8. PMID: 9820487, ISSN: 0022-1767.

Zhang J, Liu X, Scherer DC, van Kaer L, Wang X, Xu M. Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45. Proc. Natl. Acad. Sci. U.S.A. 1998 Oct 10/13/1998; 95(21): 12480-5. PMID: 9770511, PMCID: PMC22856, ISSN: 0027-8424.

Salcedo M, Andersson M, Lemieux S, Van Kaer L, Chambers BJ, Ljunggren HG. Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice. Eur. J. Immunol. 1998 Apr; 28(4): 1315-21. PMID: 9565371, PII: 10.1002/(SICI)1521-4141(199804)28:04<1315::AID-IMMU1315>3.0.CO;2-2, DOI: 10.1002/(SICI)1521-4141(199804)28:04<1315::AID-IMMU1315>3.0.CO;2-2, ISSN: 0014-2980.

Bikoff EK, Kenty G, Van Kaer L. Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms. J. Immunol. 1998 Apr 4/1/1998; 160(7): 3101-10. PMID: 9531264, ISSN: 0022-1767.

Kovats S, Grubin CE, Eastman S, deRoos P, Dongre A, Van Kaer L, Rudensky AY. Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo. J. Exp. Med. 1998 Jan 1/19/1998; 187(2): 245-51. PMID: 9432982, PMCID: PMC2212101, ISSN: 0022-1007.

Kenty G, Martin WD, Van Kaer L, Bikoff EK. MHC class II expression in double mutant mice lacking invariant chain and DM functions. J. Immunol. 1998 Jan 1/15/1998; 160(2): 606-14. PMID: 9551894, ISSN: 0022-1767.

Freland S, Chambers BJ, Andersson M, Van Kaer L, Ljunggren HG. Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice. J. Immunol. 1998 Jan 1/15/1998; 160(2): 572-9. PMID: 9551890, ISSN: 0022-1767.

Swier K, Brown DR, Bird JJ, Martin WD, Van Kaer L, Reiner SL. A critical, invariant chain-independent role for H2-M in antigen presentation. J. Immunol. 1998 Jan 1/15/1998; 160(2): 540-4. PMID: 9551884, ISSN: 0022-1767.

Griffin TA, Nandi D, Cruz M, Fehling HJ, Kaer LV, Monaco JJ, Colbert RA. Immunoproteasome assembly: cooperative incorporation of interferon gamma (IFN-gamma)-inducible subunits. J. Exp. Med. 1998 Jan 1/5/1998; 187(1): 97-104. PMID: 9419215, PMCID: PMC2199179, ISSN: 0022-1007.

Kawamura T, Takeda K, Mendiratta SK, Kawamura H, Van Kaer L, Yagita H, Abo T, Okumura K. Critical role of NK1+ T cells in IL-12-induced immune responses in vivo. J. Immunol. 1998 Jan 1/1/1998; 160(1): 16-9. PMID: 9551949, ISSN: 0022-1767.

Griffin, T.A., Nandi, D., Cruz, M., Fehling, H.J., Van Kaer, L., Monaco, J.J., and Colbert, R.A. Immunoproteasome assembly: cooperative incorporation of interferon g (IFN-g)-inducible subunits. J. Exp. Med. 1998; 187: 97-104.

Liu T, Chambers B, Diehl AD, Van Kaer L, Jondal M, Ljunggren HG. TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells. J. Immunol. 1997 Dec 12/1/1997; 159(11): 5364-71. PMID: 9548476, ISSN: 0022-1767.

Sant'Angelo DB, Waterbury PG, Cohen BE, Martin WD, Van Kaer L, Hayday AC, Janeway CA. The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. Immunity. 1997 Oct; 7(4): 517-24. PMID: 9354472, PII: S1074-7613(00)80373-8, ISSN: 1074-7613.

Mendiratta SK, Martin WD, Hong S, Boesteanu A, Joyce S, Van Kaer L. CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity. 1997 Apr; 6(4): 469-77. PMID: 9133426, PII: S1074-7613(00)80290-3, ISSN: 1074-7613.

Salcedo M, Diehl AD, Olsson-Alheim MY, Sundbäck J, Van Kaer L, Kärre K, Ljunggren HG. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J. Immunol. 1997 Apr 4/1/1997; 158(7): 3174-80. PMID: 9120271, ISSN: 0022-1767.

Joyce S, Negishi I, Boesteanu A, DeSilva AD, Sharma P, Chorney MJ, Loh DY, Van Kaer L. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J. Exp. Med. 1996 Oct 10/1/1996; 184(4): 1579-84. PMID: 8879233, PMCID: PMC2192848, ISSN: 0022-1007.

Martin WD, Hicks GG, Mendiratta SK, Leva HI, Ruley HE, Van Kaer L. H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell. 1996 Feb 2/23/1996; 84(4): 543-50. PMID: 8598041, PII: S0092-8674(00)81030-2, ISSN: 0092-8674.

Sandberg JK, Chambers BJ, Van Kaer L, Kärre K, Ljunggren HG. TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity. Eur. J. Immunol. 1996 Feb; 26(2): 288-93. PMID: 8617293, DOI: 10.1002/eji.1830260203, ISSN: 0014-2980.

Ljunggren HG, Van Kaer L, Sabatine MS, Auchincloss H, Tonegawa S, Ploegh HL. MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. Int. Immunol. 1995 Jun; 7(6): 975-84. PMID: 7577806, ISSN: 0953-8178.

Machold RP, Andrée S, Van Kaer L, Ljunggren HG, Ploegh HL. Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains. J. Exp. Med. 1995 Mar 3/1/1995; 181(3): 1111-22. PMID: 7869032, PMCID: PMC2191915, ISSN: 0022-1007.

Martien van Santen H, Woolsey A, Rickardt PG, Van Kaer L, Baas EJ, Berns A, Tonegawa S, Ploegh HL. Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene. J. Exp. Med. 1995 Feb 2/1/1995; 181(2): 787-92. PMID: 7836931, PMCID: PMC2191882, ISSN: 0022-1007.

Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Ploegh HL. Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice. Eur. J. Immunol. 1995 Jan; 25(1): 174-8. PMID: 7843229, DOI: 10.1002/eji.1830250129, ISSN: 0014-2980.

Ljunggren, H.G., and Van Kaer, L. Antigen presentation and T cell development in TAP1 deficient mice. Immunologist. 1995; 3: 136-40.

Van Kaer L, Ashton-Rickardt PG, Eichelberger M, Gaczynska M, Nagashima K, Rock KL, Goldberg AL, Doherty PC, Tonegawa S. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity. 1994 Oct; 1(7): 533-41. PMID: 7600282, PII: 1074-7613(94)90043-4, ISSN: 1074-7613.

Aldrich CJ, Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Forman J. Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc. Natl. Acad. Sci. U.S.A. 1994 Jul 7/5/1994; 91(14): 6525-8. PMID: 8022816, PMCID: PMC44235, ISSN: 0027-8424.

Ljunggren HG, Van Kaer L, Ploegh HL, Tonegawa S. Altered natural killer cell repertoire in Tap-1 mutant mice. Proc. Natl. Acad. Sci. U.S.A. 1994 Jul 7/5/1994; 91(14): 6520-4. PMID: 8022815, PMCID: PMC44234, ISSN: 0027-8424.

Ashton-Rickardt PG, Bandeira A, Delaney JR, Van Kaer L, Pircher HP, Zinkernagel RM, Tonegawa S. Evidence for a differential avidity model of T cell selection in the thymus. Cell. 1994 Feb 2/25/1994; 76(4): 651-63. PMID: 8124708, PII: 0092-8674(94)90505-3, ISSN: 0092-8674.

Moriwaki S, Korn BS, Ichikawa Y, van Kaer L, Tonegawa S. Amino acid substitutions in the floor of the putative antigen-binding site of H-2T22 affect recognition by a gamma delta T-cell receptor. Proc. Natl. Acad. Sci. U.S.A. 1993 Dec 12/1/1993; 90(23): 11396-400. PMID: 8248260, PMCID: PMC47989, ISSN: 0027-8424.

Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S. Repertoire-determining role of peptide in the positive selection of CD8+ T cells. Immunol. Rev. 1993 Oct; 135: 157-82. PMID: 8282312, ISSN: 0105-2896.

Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell. 1993 Jun 6/4/1993; 73(5): 1041-9. PMID: 8500174, PII: 0092-8674(93)90281-T, ISSN: 0092-8674.

Van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell. 1992 Dec 12/24/1992; 71(7): 1205-14. PMID: 1473153, PII: S0092-8674(05)80068-6, ISSN: 0092-8674.

Wu M, van Kaer L, Itohara S, Tonegawa S. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. J. Exp. Med. 1991 Jul 7/1/1991; 174(1): 213-8. PMID: 1711563, PMCID: PMC2118879, ISSN: 0022-1007.

Van Kaer L, Wu M, Ichikawa Y, Ito K, Bonneville M, Ostrand-Rosenberg S, Murphy DB, Tonegawa S. Recognition of MHC TL gene products by gamma delta T cells. Immunol. Rev. 1991 Apr; 120: 89-115. PMID: 1830863, ISSN: 0105-2896.

Ito K, Van Kaer L, Bonneville M, Hsu S, Murphy DB, Tonegawa S. Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Cell. 1990 Aug 8/10/1990; 62(3): 549-61. PMID: 2379238, PII: 0092-8674(90)90019-B, ISSN: 0092-8674.

Bowler C, Van Kaer L, Van Camp W, Van Montagu M, Inzé D, Dhaese P. Characterization of the Bacillus stearothermophilus manganese superoxide dismutase gene and its ability to complement copper/zinc superoxide dismutase deficiency in Saccharomyces cerevisiae. J. Bacteriol. 1990 Mar; 172(3): 1539-46. PMID: 2407726, PMCID: PMC208630, ISSN: 0021-9193.

Van Kaer L, Van Montagu M, Dhaese P. Purification and in vitro DNA-binding specificity of the Bacillus subtilis phage phi 105 repressor. J. Biol. Chem. 1989 Sep 9/5/1989; 264(25): 14784-91. PMID: 2549036, ISSN: 0021-9258.

Van Kaer L, Gansemans Y, Van Montagu M, Dhaese P. Interaction of the Bacillus subtilis phage phi 105 repressor DNA: a genetic analysis. EMBO J. 1988 Mar; 7(3): 859-66. PMID: 3135184, PMCID: PMC454403, ISSN: 0261-4189.

Van Kaer L, Van Montagu M, Dhaese P. Transcriptional control in the EcoRI-F immunity region of Bacillus subtilis phage phi 105. Identification and unusual structure of the operator. J. Mol. Biol. 1987 Sep 9/5/1987; 197(1): 55-67. PMID: 3119860, PII: 0022-2836(87)90609-7, ISSN: 0022-2836.

Available Postdoctoral Position Details
Posted: 4/23/2021

Postdoctoral position in immunometabolism

The Van Kaer and Wu labs at Vanderbilt University Medical Center are recruiting a post-doctoral scholar for an NIH-funded project to study the contribution of autophagy and related cellular processes to the development and function of various cells of the immune system.

The overall goal of our research program is to explore the interactions between the immune and metabolic systems, in an emerging field called immunometabolism. In our studies, we employ a variety of genetically engineered mice with selective defects of autophagy-related factors in specific cell types of the immune or metabolic systems. We also employ a variety of mouse models of human disease, including models of multiple sclerosis, cancer, inflammatory bowel disease, obesity-associated type 2 diabetes, and myocardial infarction. Please visit our lab website for more information:

Candidates should have a PhD with skills in basic immunology techniques involving mouse models. Experience in cell biology, molecular biology, metabolism, and/or disease models would also be appreciated. Successful candidates will be self-motivated and have strong interpersonal and communication skills. Please send your application with a cover letter stating research interests and career goals, full CV, and contact information for three references to Dr. Van Kaer (