Charles W. Stratton, M.D.

Associate Professor

charles.stratton@vanderbilt.edu
Faculty Appointments
Associate Professor of Pathology, Microbiology and Immunology Associate Professor of Medicine
Education
M.D., University of Vermont, Burlington, VermontB.S., Chemistry, Bates College, Lewiston, Maine
Office Address
4525 TVC
The Vanderbilt Clinic
21st & Edgehill Road
Nashville, TN 5310
Research Description
Dr. Stratton is an Associate Professor of Pathology and Medicine, and Director of the Clinical Microbiology Laboratory. He has a long publishing history in clinical microbiology.

Dr. Stratton’s primary research is in pharmcodynamics , particularly the mechanisms of resistance. He has authored or co-authored over 200 papers on this subject and is recognized as an international authority in this area. Dr. Stratton has served on a number of editorial boards. Dr. Stratton is a retired Colonel in the U.S. Army Reserves. He received the Bronze Star for service in the Persian Gulf War.

Dr. Stratton is a member of numerous professional organizations, and is a fellow in the American College of Physicians, College of American Pathologists , American Society of Clinical Pathologists, American Academy of Microbiology, and Infectious Diseases Society of America. For 14 years, he served as editor of “Topics in Clinical Microbiology”, a bimonthly section of Infection Control and Hospital Epidemiology.

Dr. Stratton also served as editor for Infectious Diseases Newsletter and the Antimicrobics and Infectious Diseases Newsletter. Dr. Stratton is the author of many articles, research publications, review publications, chapters, and abstracts. He has lectured extensively at teaching activities, meetings and conferences.

Research Description

Emerging infectious diseases are a recognized problem in clinical medicine. Chlamydia pneumoniae was first recognized in 1988 as a cause of community acquired respiratory tract infections. Since then, this unique pathogen has been associated with a number of chronic diseases, including atherosclerosis and asthma. The pathogenesis of Chlamydia pneumoniae and its role in chronic inflammatory diseases as a cause of secondary infection worsening the original inflammatory process is the basis of current research efforts.
Research Keywords
Pathogenesis of Chlamydia pneumoniae
Publications
Stratton CW, Wheldon DB. Multiple sclerosis: an infectious syndrome involving Chlamydophila pneumoniae. Trends Microbiol. 2006.

Sriram, S., Yao, S.Y., Stratton, C.W., Moses, H. Narayana, P.A., Wolinsky, J.S.. Pilot study to examine the effect of antibiotic therapy on MRI outcomes in RRMS. J. Neurol. Sci. 2005; 234: 87-91.

Sriram S, Yao S, Mitchell WM, Calibresi P, Stratton CW, Ikejima H, Yamamoto Y. Comparative study of the presence of Chlamydia pneumoniae in cerebrospinal fluid from clinically definite and monosympomatic muliple sclerosis patinets. Clinical and Diagnostic Laboratory Immunology. 2003; 9: 1332-7.

Sams HH, Mitchell WM, Stratton CW, King LE. Culture and immunhistochemical evidence of Chlamydia pneumoniae in pyoderma gangrenosum. Journal of the American Academy of Dermatology. 2003; 48: 966-9.

Alberts GL, Mitchell WM, Stratton CW, Franke JJ. Interstitial cystitis: can Chlamydia pneumoniae be a cause?. Infections in Urology. 2003; 16: 19-21.

Stratton CW, Sriram S. Association of Chlamydia pneumoniae with central nervous system disease. Microbes Infect. 2003; 5((13)): 1249-53.

King LE Jr, Stratton CW, Mitchell WM. Chlamydia pneumoniae and chronic skin infections: a focused review. Journal of Investigative Dermatology Symposium Proceedings. 2002; 6: 233-7.

Yoa S, Stratton CW, Mitchell WM, Sriram S. Cerebral spinal fluid oligoclonal bands in multiple sclerosis represent antibodies against Chlamydiophila. Neurology. 2001; 56: 1168-76.

Yao SY, Rose A, Stratton CW, Mitchell WM, Sriram S. Regulation by beta interferon of inducible nitric oxide synthase and interleukin 12/p40 in murine macrophages exposed to Chlamydia pneumoniae antigens. Journal of Interferon and Cytokine Research. 2001; 21: 137-46.

King LE Jr, Bushman T, Stratton CW, Mitchell WM. Diabetic foot ulcers and Chlamydia pneumoniae: innocent bystander or opportunistic pathogen. Archives of Dermatology. 2001; 42: 295-7.

Vannucci SA, Mithcell WM, Stratton CW, King LE Jr. Pyoderma gangrenosum and Chlamydia pneumoniae infection in a diabetic man: pahtognic role or coincidence?. Journal of the American Academy of Dermatology. 2000; 42: 295-7.

Stratton CW, Warner RR, Coudron PE, Lilly NA. Bismuth- mediated disruption of the glycocalyx-cell wall of Helicobacter pylori ultrastructure evidence for a mechanism of action for bismuth salts. 1999.

Coudron PE, Stratton CW. In-vitro evaluation of nitrofurantoin as an alternative agent for metronidazole in combination antimicrobial therapy against Helicobacter pylori. 1998.

Sriram S, Mitchell W, Stratton C. Multiple sclerosis associated with Chlamydia pneumoniae infection of the CNS. 1998.

Norris SR, Stratton CW, Kernodle DS. Production of A and C variants of staphylococcal beta-lactamase by methicillin-resistant strains of Staphylococcus aureus. 1994.

Macon WR, Lo SC, Poiesz BJ, Montefiori DC, Masn TE, Michael PR, Cohen AG, Davis CM, Cousar JM, Stratton CW. AIDS-like illness associated with Mycoplasma fermentans (incognetus strain) infection in an HIV-negative homosexual male. 1993.

Zygmunt DJ, Stratton CW, Kernodle DS. Characterization of four beta-lactamases produced by Staphylococcus aureus. 1992.

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