Mary Ann Thompson Arildsen, M.D., Ph.D.

Associate Professor
Faculty Appointments
Associate Professor of Pathology, Microbiology and Immunology
Ph.D., Immunology, University of Pennsylvania, Philadelphia, PennsylvaniaM.D., Medicine, University of Pennsylvania, Philadelphia, PennsylvaniaB.S., Yale University, New Haven, ConnecticutM.S., Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut
Office Address
4605 TVC
Department of Pathology
Nashville, TN 37232
Research Description
Involved in multi-institution project performing comprehensive NGS of hematopoietic malignancies.
Research has focused on changes in microRNA in transformation of follicular lymphoma to DLBCL
Clinical Description
Medical Director, Clinical Hematology Laboratory
Research Keywords
Pathogenesis of hematopoietic malignancies
Clinical Research Keywords
Thompson MA, Edmonds MD, Liang S, McClintock-Treep S, Wang X, Li S, Eischen CM. MiR-31 and miR-17-5p levels change during transformation of follicular lymphoma. Hum. Pathol [print-electronic]. 2016 Apr; 50: 118-26. PMID: 26997445, PMCID: PMC4804154, PII: S0046-8177(15)00481-5, DOI: 10.1016/j.humpath.2015.11.011, ISSN: 1532-8392.

Wang XJ, Medeiros LJ, Lin P, Yin CC, Hu S, Thompson MA, Li S. MYC cytogenetic status correlates with expression and has prognostic significance in patients with MYC/BCL2 protein double-positive diffuse large B-cell lymphoma. Am. J. Surg. Pathol. 2015 Sep; 39(9): 1250-8. PMID: 25828389, DOI: 10.1097/PAS.0000000000000433, ISSN: 1532-0979.

Cleveland SM, Goodings C, Tripathi RM, Elliott N, Thompson MA, Guo Y, Shyr Y, Davé UP. LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp. Hematol [print-electronic]. 2014 Jul; 42(7): 581-93.e5. PMID: 24792354, PMCID: PMC4241760, PII: S0301-472X(14)00155-6, DOI: 10.1016/j.exphem.2014.04.010, ISSN: 1873-2399.

Thompson, M.A.. Wintrobe's Clinical Hematology. 13th Edition. Philadelphia (United States): Lippincott Williams & Wilkins; 2014.Chapter on Molecular Genetics of Acute Leukemia.

Smith MC, Cohen DN, Greig B, Yenamandra A, Vnencak-Jones C, Thompson MA, Kim AS. The ambiguous boundary between EBV-related hemophagocytic lymphohistiocytosis and systemic EBV-driven T cell lymphoproliferative disorder. Int J Clin Exp Pathol. 2014; 7(9): 5738-49. PMID: 25337215, PMCID: PMC4203186, ISSN: 1936-2625.

Stevens PL, Johnson DB, Thompson MA, Keedy VL, Frangoul HA, Snyder KM. Adult neuroblastoma complicated by increased intracranial pressure: a case report and review of the literature. Case Rep Oncol Med [print-electronic]. 2014; 2014: 341980. PMID: 25328733, PMCID: PMC4190830, DOI: 10.1155/2014/341980, ISSN: 2090-6706.

Smith S, Tripathi R, Goodings C, Cleveland S, Mathias E, Hardaway JA, Elliott N, Yi Y, Chen X, Downing J, Mullighan C, Swing DA, Tessarollo L, Li L, Love P, Jenkins NA, Copeland NG, Thompson MA, Du Y, Davé UP. LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways. PLoS ONE. 2014; 9(1): e85883. PMID: 24465765, PMCID: PMC3897537, PII: PONE-D-13-40599, DOI: 10.1371/journal.pone.0085883, ISSN: 1932-6203.

Seegmiller Adam, Thompson Mary Ann. Hematology and Immunology: Quality in Laboratory Diagnosis. New York City (United States): Demos Medical; 2014.95 p.

Seegmiller AC, Kim AS, Mosse CA, Levy MA, Thompson MA, Kressin MK, Jagasia MH, Strickland SA, Reddy NM, Marx ER, Sinkfield KJ, Pollard HN, Plummer WD, Dupont WD, Shultz EK, Dittus RS, Stead WW, Santoro SA, Zutter MM. Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Am. J. Clin. Pathol. 2013 Nov; 140(5): 643-50. PMID: 24124142, PMCID: PMC4159763, PII: 140/5/643, DOI: 10.1309/AJCP8CKE9NEINQFL, ISSN: 1943-7722.

Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW. HDAC3 is essential for DNA replication in hematopoietic progenitor cells. J. Clin. Invest [print-electronic]. 2013 Jul; 123(7): 3112-23. PMID: 23921131, PMCID: PMC3696547, PII: 60806, DOI: 10.1172/JCI60806, ISSN: 1558-8238.

Boelte KC, Gordy LE, Joyce S, Thompson MA, Yang L, Lin PC. Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1. PLoS ONE. 2011; 6(4): e18534. PMID: 21494556, PMCID: PMC3073977, DOI: 10.1371/journal.pone.0018534, ISSN: 1932-6203.

Davé UP, Akagi K, Tripathi R, Cleveland SM, Thompson MA, Yi M, Stephens R, Downing JR, Jenkins NA, Copeland NG. Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy. PLoS Genet [print-electronic]. 2009 May; 5(5): e1000491. PMID: 19461887, PMCID: PMC2679194, DOI: 10.1371/journal.pgen.1000491, ISSN: 1553-7404.

Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW. Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol. Cell. Biol [print-electronic]. 2008 Oct; 28(20): 6234-47. PMID: 18710942, PMCID: PMC2577421, PII: MCB.00404-08, DOI: 10.1128/MCB.00404-08, ISSN: 1098-5549.

Yang G, Thompson MA, Brandt SJ, Hiebert SW. Histone deacetylase inhibitors induce the degradation of the t(8;21) fusion oncoprotein. Oncogene [print-electronic]. 2007 Jan 1/4/2007; 26(1): 91-101. PMID: 16799637, PII: 1209760, DOI: 10.1038/sj.onc.1209760, ISSN: 0950-9232.

Salmon JS, Thompson MA, Arildsen RC, Greer JP. Non-Hodgkin's lymphoma involving the liver: clinical and therapeutic considerations. Clin Lymphoma Myeloma. 2006 Jan; 6(4): 273-80. PMID: 16507204, PII: S1557-9190(11)70402-4, ISSN: 1557-9190.

Moreno-Miralles I, Pan L, Keates-Baleeiro J, Durst-Goodwin K, Yang C, Kim HG, Thompson MA, Klug CA, Cleveland JL, Hiebert SW. The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia. J. Biol. Chem [print-electronic]. 2005 Dec 12/2/2005; 280(48): 40097-103. PMID: 16199529, PII: M506855200, DOI: 10.1074/jbc.M506855200, ISSN: 0021-9258.

Amann JM, Chyla BJ, Ellis TC, Martinez A, Moore AC, Franklin JL, McGhee L, Meyers S, Ohm JE, Luce KS, Ouelette AJ, Washington MK, Thompson MA, King D, Gautam S, Coffey RJ, Whitehead RH, Hiebert SW. Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol. Cell. Biol. 2005 Nov; 25(21): 9576-85. PMID: 16227606, PMCID: PMC1265807, PII: 25/21/9576, DOI: 10.1128/MCB.25.21.9576-9585.2005, ISSN: 0270-7306.

Yang G, Khalaf W, van de Locht L, Jansen JH, Gao M, Thompson MA, van der Reijden BA, Gutmann DH, Delwel R, Clapp DW, Hiebert SW. Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein. Mol. Cell. Biol. 2005 Jul; 25(14): 5869-79. PMID: 15988004, PMCID: PMC1168824, PII: 25/14/5869, DOI: 10.1128/MCB.25.14.5869-5879.2005, ISSN: 0270-7306.

Thompson MA, Stumph J, Henrickson SE, Rosenwald A, Wang Q, Olson S, Brandt SJ, Roberts J, Zhang X, Shyr Y, Kinney MC. Differential gene expression in anaplastic lymphoma kinase-positive and anaplastic lymphoma kinase-negative anaplastic large cell lymphomas. Hum. Pathol. 2005 May; 36(5): 494-504. PMID: 15948116, PII: S0046817705001280, DOI: 10.1016/j.humpath.2005.03.004, ISSN: 0046-8177.

Uherova P, Olson S, Thompson MA, Juskevicius R, Hamilton KS. Expression of c-FLIP in classic and nodular lymphocyte-predominant Hodgkin lymphoma. Appl. Immunohistochem. Mol. Morphol. 2004 Jun; 12(2): 105-10. PMID: 15354734, ISSN: 1541-2016.

King D, Yang G, Thompson MA, Hiebert SW. Loss of neurofibromatosis-1 and p19(ARF) cooperate to induce a multiple tumor phenotype. Oncogene. 2002 Jul 7/25/2002; 21(32): 4978-82. PMID: 12118376, DOI: 10.1038/sj.onc.1205632, ISSN: 0950-9232.

Chang L, Thompson MA. Activity of the distal positive element of the peripherin gene is dependent on proteins binding to an Ets-like recognition site and a novel inverted repeat site. J. Biol. Chem. 1996 Mar 3/15/1996; 271(11): 6467-75. PMID: 8626448, ISSN: 0021-9258.

Adams AD, Choate DM, Thompson MA. NF1-L is the DNA-binding component of the protein complex at the peripherin negative regulatory element. J. Biol. Chem. 1995 Mar 3/24/1995; 270(12): 6975-83. PMID: 7896848, ISSN: 0021-9258.