William E. Lawson, M.D.

Associate Professor

Faculty Appointments
Associate Professor of Medicine
M.D., University of Tennessee Center for Health Science, Memphis, TennesseeB.S., Tennessee Technological University, Cookeville, Tennessee
Office Address
T-1218 MCN
TN 2650
Tanjore H, Blackwell TS, Lawson WE. Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Apr 4/15/2012; 302(8): L721-9. PMID: 22287606, PMCID: PMC3331582, PII: ajplung.00410.2011, DOI: 10.1152/ajplung.00410.2011, ISSN: 1522-1504.

Polosukhin VV, Degryse AL, Newcomb DC, Jones BR, Ware LB, Lee JW, Loyd JE, Blackwell TS, Lawson WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp. Lung Res. 2012 Apr; 38(3): 135-46. PMID: 22394287, PMCID: PMC4046254, DOI: 10.3109/01902148.2012.658595, ISSN: 1521-0499.

Degryse AL, Xu XC, Newman JL, Mitchell DB, Tanjore H, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Phillips JA, Cogan JD, Blackwell TS, Lawson WE. Telomerase deficiency does not alter bleomycin-induced fibrosis in mice. Exp. Lung Res. 2012 Apr; 38(3): 124-34. PMID: 22394286, PMCID: PMC4046256, DOI: 10.3109/01902148.2012.658148, ISSN: 1521-0499.

Kropski JA, Lawson WE, Blackwell TS. Right place, right time: the evolving role of herpesvirus infection as a "second hit" in idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Mar 3/1/2012; 302(5): L441-4. PMID: 22180659, PMCID: PMC3311513, PII: ajplung.00335.2011, DOI: 10.1152/ajplung.00335.2011, ISSN: 1522-1504.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Oct; 301(4): L615-22. PMID: 21764988, PMCID: PMC3774255, PII: ajplung.00224.2010, DOI: 10.1152/ajplung.00224.2010, ISSN: 1522-1504.

Tanjore H, Cheng DS, Degryse AL, Zoz DF, Abdolrasulnia R, Lawson WE, Blackwell TS. Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. J. Biol. Chem [print-electronic]. 2011 Sep 9/2/2011; 286(35): 30972-80. PMID: 21757695, PMCID: PMC3162456, PII: M110.181164, DOI: 10.1074/jbc.M110.181164, ISSN: 1083-351X.

Polosukhin VV, Cates JM, Lawson WE, Zaynagetdinov R, Milstone AP, Massion PP, Ocak S, Ware LB, Lee JW, Bowler RP, Kononov AV, Randell SH, Blackwell TS. Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med [print-electronic]. 2011 Aug 8/1/2011; 184(3): 317-27. PMID: 21512171, PMCID: PMC3265275, PII: 201010-1629OC, DOI: 10.1164/rccm.201010-1629OC, ISSN: 1535-4970.

Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Jun 6/28/2011; 108(26): 10562-7. PMID: 21670280, PMCID: PMC3127925, PII: 1107559108, DOI: 10.1073/pnas.1107559108, ISSN: 1091-6490.

Degryse AL, Lawson WE. Progress toward improving animal models for idiopathic pulmonary fibrosis. Am. J. Med. Sci. 2011 Jun; 341(6): 444-9. PMID: 21613932, PMCID: PMC3103078, PII: 00000441-201106000-00006, DOI: 10.1097/MAJ.0b013e31821aa000, ISSN: 1538-2990.

Lawson WE, Loyd JE, Degryse AL. Genetics in pulmonary fibrosis--familial cases provide clues to the pathogenesis of idiopathic pulmonary fibrosis. Am. J. Med. Sci. 2011 Jun; 341(6): 439-43. PMID: 21613931, PMCID: PMC3103077, PII: 00000441-201106000-00005, DOI: 10.1097/MAJ.0b013e31821a9d7a, ISSN: 1538-2990.

Zoz DF, Lawson WE, Blackwell TS. Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction. Am. J. Med. Sci. 2011 Jun; 341(6): 435-8. PMID: 21613930, PMCID: PMC3103044, PII: 00000441-201106000-00004, DOI: 10.1097/MAJ.0b013e31821a9d8e, ISSN: 1538-2990.

Polosukhin VV, Cates JM, Lawson WE, Milstone AP, Matafonov AG, Massion PP, Lee JW, Randell SH, Blackwell TS. Hypoxia-inducible factor-1 signalling promotes goblet cell hyperplasia in airway epithelium. J. Pathol. 2011 Jun; 224(2): 203-11. PMID: 21557221, DOI: 10.1002/path.2863, ISSN: 1096-9896.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, Boomershine CS, Ortiz C, Sherrill TP, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. TGFß signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Jun; 300(6): L887-97. PMID: 21441353, PMCID: PMC3119129, PII: ajplung.00397.2010, DOI: 10.1152/ajplung.00397.2010, ISSN: 1522-1504.

Degryse AL, Tanjore H, Xu XC, Polosukhin VV, Jones BR, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2010 Oct; 299(4): L442-52. PMID: 20562227, PMCID: PMC2957416, PII: ajplung.00026.2010, DOI: 10.1152/ajplung.00026.2010, ISSN: 1522-1504.

Crossno PF, Polosukhin VV, Blackwell TS, Johnson JE, Markin C, Moore PE, Worrell JA, Stahlman MT, Phillips JA, Loyd JE, Cogan JD, Lawson WE. Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest. 2010 Apr; 137(4): 969-73. PMID: 20371530, PMCID: PMC2851554, PII: 137/4/969, DOI: 10.1378/chest.09-0790, ISSN: 1931-3543.

Tanjore H, Xu XC, Polosukhin VV, Degryse AL, Li B, Han W, Sherrill TP, Plieth D, Neilson EG, Blackwell TS, Lawson WE. Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis. Am. J. Respir. Crit. Care Med [print-electronic]. 2009 Oct 10/1/2009; 180(7): 657-65. PMID: 19556518, PMCID: PMC2753790, PII: 200903-0322OC, DOI: 10.1164/rccm.200903-0322OC, ISSN: 1535-4970.

Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA. Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells. Gut [print-electronic]. 2009 Sep; 58(9): 1267-74. PMID: 19625278, PMCID: PMC2719085, PII: gut.2008.170779, DOI: 10.1136/gut.2008.170779, ISSN: 1468-3288.

Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, Lane KB, Blackwell TR, Xu C, Markin C, Ware LB, Miller GG, Loyd JE, Blackwell TS. Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 Jun; 294(6): L1119-26. PMID: 18390830, PII: 00382.2007, DOI: 10.1152/ajplung.00382.2007, ISSN: 1040-0605.

Zhang H, Lawson WE, Polosukhin VV, Pozzi A, Blackwell TS, Litingtung Y, Chiang C. Inhibitor of differentiation 1 promotes endothelial survival in a bleomycin model of lung injury in mice. Am. J. Pathol [print-electronic]. 2007 Oct; 171(4): 1113-26. PMID: 17717145, PMCID: PMC1988863, PII: S0002-9440(10)62377-2, DOI: 10.2353/ajpath.2007.070226, ISSN: 0002-9440.

Polosukhin VV, Lawson WE, Milstone AP, Egunova SM, Kulipanov AG, Tchuvakin SG, Massion PP, Blackwell TS. Association of progressive structural changes in the bronchial epithelium with subepithelial fibrous remodeling: a potential role for hypoxia. Virchows Arch [print-electronic]. 2007 Oct; 451(4): 793-803. PMID: 17674038, DOI: 10.1007/s00428-007-0469-5, ISSN: 0945-6317.

Lawson WE, Loyd JE. The genetic approach in pulmonary fibrosis: can it provide clues to this complex disease?. Proc Am Thorac Soc. 2006 Jun; 3(4): 345-9. PMID: 16738199, PMCID: PMC2658686, PII: 3/4/345, DOI: 10.1513/pats.200512-137TK, ISSN: 1546-3222.

Stathopoulos GT, Zhu Z, Everhart MB, Kalomenidis I, Lawson WE, Bilaceroglu S, Peterson TE, Mitchell D, Yull FE, Light RW, Blackwell TS. Nuclear factor-kappaB affects tumor progression in a mouse model of malignant pleural effusion. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2006 Feb; 34(2): 142-50. PMID: 16210694, PMCID: PMC2644178, PII: 2005-0130OC, DOI: 10.1165/rcmb.2005-0130OC, ISSN: 1044-1549.

Lawson WE, Polosukhin VV, Stathopoulos GT, Zoia O, Han W, Lane KB, Li B, Donnelly EF, Holburn GE, Lewis KG, Collins RD, Hull WM, Glasser SW, Whitsett JA, Blackwell TS. Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin. Am. J. Pathol. 2005 Nov; 167(5): 1267-77. PMID: 16251411, PMCID: PMC1603790, PII: S0002-9440(10)61214-X, DOI: 10.1016/S0002-9440(10)61214-X, ISSN: 0002-9440.

Cheng Q, Zhao Y, Lawson WE, Polosukhin VV, Johnson JE, Blackwell TS, Gailani D. The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice. Blood [print-electronic]. 2005 Nov 11/1/2005; 106(9): 3055-7. PMID: 15985536, PMCID: PMC1895339, PII: 2005-02-0577, DOI: 10.1182/blood-2005-02-0577, ISSN: 0006-4971.

Lawson WE, Polosukhin VV, Zoia O, Stathopoulos GT, Han W, Plieth D, Loyd JE, Neilson EG, Blackwell TS. Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. Am. J. Respir. Crit. Care Med [print-electronic]. 2005 Apr 4/15/2005; 171(8): 899-907. PMID: 15618458, PII: 200311-1535OC, DOI: 10.1164/rccm.200311-1535OC, ISSN: 1073-449X.

Polosukhin VV, Stathopoulos GT, Lawson WE, Blackwell TS. Variability of interalveolar septal remodeling after bleomycin treatment in mice. Ultrastruct Pathol. 2005 Jan; 29(1): 53-64. PMID: 15934165, ISSN: 0191-3123.

Lawson WE, Grant SW, Ambrosini V, Womble KE, Dawson EP, Lane KB, Markin C, Renzoni E, Lympany P, Thomas AQ, Roldan J, Scott TA, Blackwell TS, Phillips JA, Loyd JE, du Bois RM. Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF. Thorax. 2004 Nov; 59(11): 977-80. PMID: 15516475, PMCID: PMC1746860, PII: 59/11/977, DOI: 10.1136/thx.2004.026336, ISSN: 0040-6376.