Faculty Appointments
Professor of Medicine
Associate Professor of Cell & Developmental BiologyProfessor of Pathology, Microbiology and Immunology
Education
M.D., Medicine, Vanderbilt University, Nashville, TennesseeB.A., Biology, College of the Holy Cross, Worcester, Massachusetts
Office Address
T-1217 MCN
1161 21st Avenue South
Nashville, TN 37232
1161 21st Avenue South
Nashville, TN 37232
Research Description
The goal of my research program is to understand the pathophysiology of acute respiratory distress syndrome (ARDS) and sepsis and to uncover novel approaches to prevention and treatment of these devastating conditions. As a physician-scientist, my aim is to uncover novel mechanisms that contribute to the development of sepsis and ARDS with the ultimate goal of identifying new biologic targets and unique therapeutic approaches that can be translated to clinical practice.
My lab has two major focus areas: the role of cell free-hemoglobin in modulating endothelial and lung epithelial permeability in sepsis and ARDS and the role of tissue factor, the initiator of the extrinsic coagulation cascade, in mediating lung epithelial injury and repair. I have experience with mouse models of acute lung injury as well as with modeling the epithelial barrier for in vitro study. I have developed several novel murine and cell culture model systems to study the function of TF in ALI. My research is translational and combines studies in cell culture, human and mouse experimental models, and human samples from patients with sepsis and ARDS.
My lab has two major focus areas: the role of cell free-hemoglobin in modulating endothelial and lung epithelial permeability in sepsis and ARDS and the role of tissue factor, the initiator of the extrinsic coagulation cascade, in mediating lung epithelial injury and repair. I have experience with mouse models of acute lung injury as well as with modeling the epithelial barrier for in vitro study. I have developed several novel murine and cell culture model systems to study the function of TF in ALI. My research is translational and combines studies in cell culture, human and mouse experimental models, and human samples from patients with sepsis and ARDS.
Research Keywords
Translational research in acute lung injury and sepsis focusing on molecular mechanisms, tissue factor. coagulation cascade, cell-free hemoglobin and gender.
Publications
Smith R, Harrison F, Bastarache J, Williams Roberson S, Zaganjor E, Pandharipande P, Rice T, Ely W. Potential therapeutic benefit of exogenous ketone ester administration in delirium: a narrative review. Crit Care. 2025 Oct 10/7/2025; 29(1): 424. PMID: 41057929, PMCID: PMC12505581, PII: 10.1186/s13054-025-05680-5, DOI: 10.1186/s13054-025-05680-5, ISSN: 1466-609X.
Eichelberger KR, Podar NA, Mei JA, Curry JM, Chandrasekaran R, Paul S, Bastarache JA, Torres VJ, Peters BM, Cassat JE. Candida albicans activates Staphylococcus aureus virulence regulatory systems to drive toxin-mediated human cell death. BioRxiv. 2025 Oct 10/3/2025; PMID: 41256409, PMCID: PMC12621760, PII: 2025.10.03.680095, DOI: 10.1101/2025.10.03.680095, ISSN: 2692-8205.
Shimoda LA, Alvira CM, Bastarache JA, Britt RD, Knipe RS, Kuebler WM, Moreira TS, Schmidt EP. Opportunity knocks: the fourth cohort of the American Journal of Physiology-Lung Cellular and Molecular Physiology Early Career Editorial Fellowship Program [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2025 Sep 9/1/2025; 329(3): L324-L326-L326. PMID: 40701621, DOI: 10.1152/ajplung.00238.2025, ISSN: 1522-1504.
Sanchez PA, Obeidalla S, Kerchberger VE, Moore AR, Maddali MV, Kangelaris KN, Hendrickson CM, Evrard B, Liu KD, Bastarache JA, Matthay MA, Rogers AJ, Calfee CS. Heterogeneity in association of myocardial injury and mortality in sepsis or acute respiratory distress syndrome by subphenotype: a retrospective study. Crit Care. 2025 Aug 8/19/2025; 29(1): 363. PMID: 40826103, PMCID: PMC12363128, PII: 10.1186/s13054-025-05613-2, DOI: 10.1186/s13054-025-05613-2, ISSN: 1466-609X.
Lee HNR, Lin J, Smith CJ, Ware LB, Harrison FE, Bastarache JA, Baer B. Advanced Age in Mice Exacerbates Sepsis-Induced Inflammation, Vascular Permeability, and Multi-Organ Dysfunction. Shock [print-electronic]. 2025 Jun 6/26/2025; PMID: 40668087, PII: 00024382-990000000-00698, DOI: 10.1097/SHK.0000000000002657, ISSN: 1540-0514.
Riedmann KJ, Meegan JE, Afzal A, Cervantes-Cruz Y, Obeidalla S, Bogart AM, Ware LB, Shaver CM, Bastarache JA. Oxidized Cell-Free Hemoglobin Induces Mitochondrial Dysfunction by Activation of the Mitochondrial Permeability Transition Pore in the Pulmonary Microvasculature. Microcirculation. 2025 May; 32(4): e70012. PMID: 40394906, PMCID: PMC12093041, DOI: 10.1111/micc.70012, ISSN: 1549-8719.
Meegan JE, Riedmann KJ, Gonski S, Douglas JS, Bogart AM, Ware LB, Bastarache JA. Oxidation of low-density lipoprotein by hemoglobin causes pulmonary microvascular endothelial barrier dysfunction through lectin-like oxidized LDL receptor 1. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2025 May 5/1/2025; 328(5): L748-L755-L755. PMID: 40249953, PMCID: PMC12117588, DOI: 10.1152/ajplung.00026.2025, ISSN: 1522-1504.
Shimoda LA, Bastarache JA, Britt RD, Kuebler WM. Every breath you take: exploring macrophages and environmental exposures in the lung-a tribute to Dr. Joseph Brain's legacy [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2025 Mar 3/1/2025; 328(3): L321-L323-L323. PMID: 39823196, DOI: 10.1152/ajplung.00407.2024, ISSN: 1522-1504.
Stier MT, Sewell AE, Mwizerwa EL, Sim CY, Tanner SM, Nichols CM, Durai HH, Jennings EQ, Lindau P, Wilfong EM, Newcomb DC, Bastarache JA, Ware LB, Rathmell JC. Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis. BioRxiv. 2025 Jan 1/29/2025; PMID: 39975258, PMCID: PMC11838299, PII: 2025.01.27.635146, DOI: 10.1101/2025.01.27.635146, ISSN: 2692-8205.
Baer B, Lin J, Schaaf KR, Ware LB, Shaver CM, Bastarache JA. Matrix metalloproteinase-7 is dispensable in a mouse model of sepsis-induced acute lung injury. PLoS One. 2025; 20(5): e0321349. PMID: 40341670, PMCID: PMC12061409, PII: PONE-D-24-46782, DOI: 10.1371/journal.pone.0321349, ISSN: 1932-6203.
Meegan JE, Rizzo AN, Schmidt EP, Bastarache JA. Cellular Mechanisms of Lung Injury: Current Perspectives. Clin Chest Med [print-electronic]. 2024 Dec; 45(4): 821-33. PMID: 39443000, PMCID: PMC11499619, PII: S0272-5231(24)00066-2, DOI: 10.1016/j.ccm.2024.08.004, ISSN: 1557-8216.
Bogart AM, Lopez CR, Obeidalla SN, Wang C, Willmore A, Jauregui A, Kangelaris KN, Hendrickson C, Gomez A, Liu KD, Matthay MA, Shaver CM, Bastarache JA, Calfee CS, Kerchberger VE, Ware LB. Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies. CHEST Crit Care [print-electronic]. 2024 Sep; 2(3): PMID: 39421542, PMCID: PMC11485198, PII: 100082, DOI: 10.1016/j.chstcc.2024.100082, ISSN: 2949-7884.
Murphy MB, Yang Z, Subati T, Farber-Eger E, Kim K, Blackwell DJ, Fleming MR, Stark JM, Van Amburg JC, Woodall KK, Van Beusecum JP, Agrawal V, Smart CD, Pitzer A, Atkinson JB, Fogo AB, Bastarache JA, Kirabo A, Wells QS, Madhur MS, Barnett JV, Murray KT. LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation. Cardiovasc Res. 2024 Jul 7/2/2024; 120(8): 899-913. PMID: 38377486, PMCID: PMC11218690, PII: 7611672, DOI: 10.1093/cvr/cvae036, ISSN: 1755-3245.
Kuhar E, Chander N, Stewart DJ, Jahandideh F, Zhang H, Kristof AS, Bastarache JA, Schmidt EP, Taljaard M, Thebaud B, Engelberts D, Fergusson DA, Lalu MM. A preclinical systematic review and meta-analysis assessing the effect of biological sex in lipopolysaccharide-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2024 Jun 6/1/2024; 326(6): L661-L671-L671. PMID: 38349120, PMCID: PMC11905864, DOI: 10.1152/ajplung.00336.2023, ISSN: 1522-1504.
Matthay MA, Schmidt EP, Bastarache JA, Calfee CS, Frevert CW, Martin TR. The Translational Value of Rodent Models of Sepsis. Am J Respir Crit Care Med. 2024 Mar 3/1/2024; 209(5): 488-90. PMID: 38091521, PMCID: PMC10919117, DOI: 10.1164/rccm.202308-1489VP, ISSN: 1535-4970.
Zehr EP, Erzen CL, Oshima K, Langouet-Astrie CJ, LaRiviere WB, Shi D, Zhang F, McCollister BD, Windham SL, Rizzo AN, Bastarache JA, Horswill AR, Schmidt EP, Kwiecinski JM, Colbert JF. Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2024 Feb 2/1/2024; 326(2): L206-L212-L212. PMID: 38113313, PMCID: PMC11280675, DOI: 10.1152/ajplung.00178.2023, ISSN: 1522-1504.
Schaaf KR, Landstreet SR, Putz ND, Gonski SK, Lin J, Buggs CJ, Gibson D, Langouët-Astrié CJ, Jetter CS, Negretti NM, Sucre JMS, Schmidt EP, Ware LB, Bastarache JA, Shaver CM. Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx. PLoS One. 2024; 19(9): e0308648. PMID: 39312544, PMCID: PMC11419339, PII: PONE-D-24-21637, DOI: 10.1371/journal.pone.0308648, ISSN: 1932-6203.
Schaaf KR, Landstreet SR, Pugazenthi S, Qian EY, Putz ND, Siderova T, Owen AM, Bohannon JK, Ware LB, Bastarache JA, Shaver CM. Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2024 Jan 1/1/2024; 326(1): L29-L38-L38. PMID: 37991487, PMCID: PMC11279742, DOI: 10.1152/ajplung.00123.2023, ISSN: 1522-1504.
Bain W, Bastarache JA, Sarma A, McElvaney NG, Baron RM, McVerry BJ, Kitsios GD. Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs [letter]. Ann Am Thorac Soc. 2024 Jan; 21(1): 183-4. PMID: 37776282, PMCID: PMC10867904, DOI: 10.1513/AnnalsATS.202306-589LE, ISSN: 2325-6621.
Bejoy J, Farry JM, Qian ES, Dearing CH, Ware LB, Bastarache JA, Woodard LE. Ascorbate protects human kidney organoids from damage induced by cell-free hemoglobin. Dis Model Mech [print-electronic]. 2023 Dec 12/1/2023; 16(12): PMID: 37942584, PMCID: PMC10695115, PII: 334691, DOI: 10.1242/dmm.050342, ISSN: 1754-8411.
Shuey MM, Stead WW, Aka I, Barnado AL, Bastarache JA, Brokamp E, Campbell M, Carroll RJ, Goldstein JA, Lewis A, Malow BA, Mosley JD, Osterman T, Padovani-Claudio DA, Ramirez A, Roden DM, Schuler BA, Siew E, Sucre J, Thomsen I, Tinker RJ, Van Driest S, Walsh C, Warner JL, Wells QS, Wheless L, Bastarache L. Next-generation phenotyping: introducing phecodeX for enhanced discovery research in medical phenomics. Bioinformatics. 2023 Nov 11/1/2023; 39(11): PMID: 37930895, PMCID: PMC10627409, PII: 7335839, DOI: 10.1093/bioinformatics/btad655, ISSN: 1367-4811.
Goodman RS, Patrinely JR, Stone CA, Zimmerman E, Donald RR, Chang SS, Berkowitz ST, Finn AP, Jahangir E, Scoville EA, Reese TS, Friedman DL, Bastarache JA, van der Heijden YF, Wright JJ, Ye F, Carter N, Alexander MR, Choe JH, Chastain CA, Zic JA, Horst SN, Turker I, Agarwal R, Osmundson E, Idrees K, Kiernan CM, Padmanabhan C, Bailey CE, Schlegel CE, Chambless LB, Gibson MK, Osterman TJ, Wheless LE, Johnson DB. Accuracy and Reliability of Chatbot Responses to Physician Questions. JAMA Netw Open. 2023 Oct 10/2/2023; 6(10): e2336483. PMID: 37782499, PMCID: PMC10546234, PII: 2809975, DOI: 10.1001/jamanetworkopen.2023.36483, ISSN: 2574-3805.
Baer B, Putz ND, Riedmann K, Gonski S, Lin J, Ware LB, Toki S, Peebles RS, Cahill KN, Bastarache JA. Liraglutide pretreatment attenuates sepsis-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2023 Sep 9/1/2023; 325(3): L368-L384-L384. PMID: 37489855, PMCID: PMC10639010, DOI: 10.1152/ajplung.00041.2023, ISSN: 1522-1504.
Pandharipande P, Williams Roberson S, Harrison FE, Wilson JE, Bastarache JA, Ely EW. Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness. Lancet Respir Med [print-electronic]. 2023 Aug; 11(8): 726-38. PMID: 37475124, PMCID: PMC10706757, PII: S2213-2600(23)00238-2, DOI: 10.1016/S2213-2600(23)00238-2, ISSN: 2213-2619.
Davis A, Johnson DB, Bastarache JA. Long-term outcomes in patients with immune checkpoint inhibitor induced pneumonitis. BMJ Open Respir Res. 2023 Apr 4/6/2023; 10(1): PMID: 40042935, PMCID: PMC10083847, PII: 10/1/e001342, DOI: 10.1136/bmjresp-2022-001342, ISSN: 2052-4439.
Conger AK, Tomasek T, Riedmann KJ, Douglas JS, Berkey LE, Ware LB, Bastarache JA, Meegan JE. Hemoglobin increases leukocyte adhesion and initiates lung microvascular endothelial activation via Toll-like receptor 4 signaling. Am J Physiol Cell Physiol [print-electronic]. 2023 Mar 3/1/2023; 324(3): C665-C673-C673. PMID: 36717098, PMCID: PMC9970650, DOI: 10.1152/ajpcell.00211.2022, ISSN: 1522-1563.
Johnson D, Goodman R, Patrinely J, Stone C, Zimmerman E, Donald R, Chang S, Berkowitz S, Finn A, Jahangir E, Scoville E, Reese T, Friedman D, Bastarache J, van der Heijden Y, Wright J, Carter N, Alexander M, Choe J, Chastain C, Zic J, Horst S, Turker I, Agarwal R, Osmundson E, Idrees K, Kieman C, Padmanabhan C, Bailey C, Schlegel C, Chambless L, Gibson M, Osterman T, Wheless L. Assessing the Accuracy and Reliability of AI-Generated Medical Responses: An Evaluation of the Chat-GPT Model. Res Sq. 2023 Feb 2/28/2023; PMID: 36909565, PMCID: PMC10002821, PII: rs.3.rs-2566942, DOI: 10.21203/rs.3.rs-2566942/v1, ISSN: 2693-5015.
Williams Roberson S, Nwosu S, Collar EM, Kiehl AL, Harrison FE, Bastarache J, Wilson JE, Mart MF, Sevransky JE, Ely EW, Lindsell CJ, Jackson JC, . Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial. JAMA Netw Open. 2023 Feb 2/1/2023; 6(2): e230380. PMID: 36853612, PMCID: PMC9975932, PII: 2801791, DOI: 10.1001/jamanetworkopen.2023.0380, ISSN: 2574-3805.
Meegan JE, Kerchberger VE, Fortune NL, McNeil JB, Bastarache JA, Austin ED, Ware LB, Hemnes AR, Brittain EL. Transpulmonary generation of cell-free hemoglobin contributes to vascular dysfunction in pulmonary arterial hypertension via dysregulated clearance mechanisms. Pulm Circ. 2023 Jan; 13(1): e12185. PMID: 36743426, PMCID: PMC9841468, PII: PUL212185, DOI: 10.1002/pul2.12185, ISSN: 2045-8932.
Consoli DC, Spitznagel BD, Owen BM, Kang H, Williams Roberson S, Pandharipande P, Wesley Ely E, Nobis WP, Bastarache JA, Harrison FE. Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis. Brain Behav Immun [print-electronic]. 2023 Jan; 107: 165-78. PMID: 36243287, PMCID: PMC10010333, PII: S0889-1591(22)00408-1, DOI: 10.1016/j.bbi.2022.10.003, ISSN: 1090-2139.
Afzal A, Beavers WN, Skaar EP, Calhoun MC, Richardson KA, Landstreet SR, Cliffel DE, Wright D, Bastarache JA, Ware LB. Ultraviolet light oxidation of fresh hemoglobin eliminates aggregate formation seen in commercially sourced hemoglobin. Blood Cells Mol Dis [print-electronic]. 2023 Jan; 98: 102699. PMID: 36027791, PMCID: PMC10024311, PII: S1079-9796(22)00056-0, DOI: 10.1016/j.bcmd.2022.102699, ISSN: 1096-0961.
Bartlett NW, Bastarache JA, Kuebler WM, Schmidt EP. Call for Papers: "In It for the Long Haul: Understanding the Lasting Impact of COVID-19 on Lung Health and Disease" [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2022 Dec 12/1/2022; 323(6): L683-L684-L684. PMID: 36346147, PMCID: PMC9870585, DOI: 10.1152/ajplung.00352.2022, ISSN: 1522-1504.
Verdonk F, Feyaerts D, Badenes R, Bastarache JA, Bouglé A, Ely W, Gaudilliere B, Howard C, Kotfis K, Lautrette A, Le Dorze M, Mankidy BJ, Matthay MA, Morgan CK, Mazeraud A, Patel BV, Pattnaik R, Reuter J, Schultz MJ, Sharshar T, Shrestha GS, Verdonk C, Ware LB, Pirracchio R, Jabaudon M. Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience. Anaesth Crit Care Pain Med [print-electronic]. 2022 Oct; 41(5): 101121. PMID: 35781076, PMCID: PMC9245393, PII: S2352-5568(22)00102-3, DOI: 10.1016/j.accpm.2022.101121, ISSN: 2352-5568.
Kerchberger VE, Bastarache JA. Pulmonary Vasculopathy in COVID-19 Acute Respiratory Distress Syndrome: A Step Closer to the Full Picture [editorial]. Am J Respir Crit Care Med. 2022 Oct 10/1/2022; 206(7): 809-10. PMID: 35675564, PMCID: PMC9799262, DOI: 10.1164/rccm.202205-1019ED, ISSN: 1535-4970.
Meegan JE, Komalavilas P, Cheung-Flynn J, Yim TW, Putz ND, Jesse JJ, Smith KD, Sidorova TN, Lee HNR, Tomasek T, Shaver CM, Ware LB, Brophy CM, Bastarache JA. Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis. Physiol Rep. 2022 Jun; 10(11): e15290. PMID: 35668576, PMCID: PMC9170948, DOI: 10.14814/phy2.15290, ISSN: 2051-817X.
Blondonnet R, Simand LA, Vidal P, Borao L, Bourguignon N, Morand D, Bernard L, Roszyk L, Audard J, Godet T, Monsel A, Garnier M, Quesnel C, Bazin JE, Sapin V, Bastarache JA, Ware LB, Hughes CG, Pandharipande PP, Ely EW, Futier E, Pereira B, Constantin JM, Jabaudon M, On Behalf Of The Sesar Collaborative Group. Design and Rationale of the Sevoflurane for Sedation in Acute Respiratory Distress Syndrome (SESAR) Randomized Controlled Trial. J Clin Med. 2022 May 5/16/2022; 11(10): PMID: 35628922, PMCID: PMC9147018, PII: jcm11102796, DOI: 10.3390/jcm11102796, ISSN: 2077-0383.
Bos LDJ, Laffey JG, Ware LB, Heijnen NFL, Sinha P, Patel B, Jabaudon M, Bastarache JA, McAuley DF, Summers C, Calfee CS, Shankar-Hari M. Towards a biological definition of ARDS: are treatable traits the solution?. Intensive Care Med Exp. 2022 Mar 3/11/2022; 10(1): 8. PMID: 35274164, PMCID: PMC8913033, PII: 10.1186/s40635-022-00435-w, DOI: 10.1186/s40635-022-00435-w, ISSN: 2197-425X.
Gandhi VD, Cephus JY, Norlander AE, Chowdhury NU, Zhang J, Ceneviva ZJ, Tannous E, Polosukhin VV, Putz ND, Wickersham N, Singh A, Ware LB, Bastarache JA, Shaver CM, Chu HW, Peebles RS, Newcomb DC. Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. J Clin Invest. 2022 Feb 2/15/2022; 132(4): PMID: 35025767, PMCID: PMC8843736, PII: 153397, DOI: 10.1172/JCI153397, ISSN: 1558-8238.
Bastarache JA, Smith K, Jesse JJ, Putz ND, Meegan JE, Bogart AM, Schaaf K, Ghosh S, Shaver CM, Ware LB. A two-hit model of sepsis plus hyperoxia causes lung permeability and inflammation. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2022 Feb 2/1/2022; 322(2): L273-L282-L282. PMID: 34936510, PMCID: PMC11684993, DOI: 10.1152/ajplung.00227.2021, ISSN: 1522-1504.
Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2022 Jan 1/25/2022; 7(2): PMID: 34874923, PMCID: PMC8855818, PII: 154573, DOI: 10.1172/jci.insight.154573, ISSN: 2379-3708.
Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med [print-electronic]. 2022 Jan; 10(1): 107-20. PMID: 34310901, PMCID: PMC8302189, PII: S2213-2600(21)00157-0, DOI: 10.1016/S2213-2600(21)00157-0, ISSN: 2213-2619.
Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE. Promoting our early career members at AJP-Lung: the Editorial Board Fellowship Program and the Next Generation Physiologist Highlights section at our Journal [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2021 Nov 11/1/2021; 321(5): L844-L846-L846. PMID: 34585617, PMCID: PMC8616620, DOI: 10.1152/ajplung.00389.2021, ISSN: 1522-1504.
McNeil JB, Jackson KE, Wang C, Siew ED, Vincz AJ, Shaver CM, Bastarache JA, Ware LB. Linear Association Between Hypoalbuminemia and Increased Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults. Crit Care Explor. 2021 Sep; 3(9): e0527. PMID: 34549190, PMCID: PMC8443821, DOI: 10.1097/CCE.0000000000000527, ISSN: 2639-8028.
Meegan JE, Bastarache JA, Ware LB. Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2021 Aug 8/1/2021; 321(2): L429-L439-L439. PMID: 34009034, PMCID: PMC8526348, DOI: 10.1152/ajplung.00018.2021, ISSN: 1522-1504.
Reynolds RA, Amin SN, Jonathan SV, Tang AR, Lan M, Wang C, Bastarache JA, Ware LB, Thompson RC. Hyperoxemia and Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care [print-electronic]. 2021 Aug; 35(1): 30-8. PMID: 33150573, PMCID: PMC8093321, PII: 10.1007/s12028-020-01136-6, DOI: 10.1007/s12028-020-01136-6, ISSN: 1556-0961.
Kerchberger VE, Brown RM, Semler MW, Zhao Z, Koyama T, Janz DR, Bastarache JA, Ware LB. Impact of Clinician Recognition of Acute Respiratory Distress Syndrome on Evidenced-Based Interventions in the Medical ICU. Crit Care Explor. 2021 Jul; 3(7): e0457. PMID: 34250497, PMCID: PMC8263322, DOI: 10.1097/CCE.0000000000000457, ISSN: 2639-8028.
Bos LDJ, Bastarache JA. Cleaving the Acute Respiratory Distress Syndrome into Treatable Traits: A Role for Caspase 1? [editorial]. Am J Respir Crit Care Med. 2021 Jul 7/1/2021; 204(1): 6-7. PMID: 33826872, PMCID: PMC8437118, DOI: 10.1164/rccm.202102-0479ED, ISSN: 1535-4970.
Tomasek T, Ware LB, Bastarache JA, Meegan JE. Cell-free hemoglobin-mediated human lung microvascular endothelial barrier dysfunction is not mediated by cell death. Biochem Biophys Res Commun [print-electronic]. 2021 Jun 6/4/2021; 556: 199-206. PMID: 33848934, PMCID: PMC8483287, PII: S0006-291X(21)00574-X, DOI: 10.1016/j.bbrc.2021.03.161, ISSN: 1090-2104.
Jabaudon M, Pereira B, Laroche E, Roszyk L, Blondonnet R, Audard J, Godet T, Futier E, Bazin JE, Sapin V, Bastarache JA, Ware LB, Constantin JM, On Behalf Of The Live Study Group And The Azurea Network. Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome. J Clin Med. 2021 May 5/12/2021; 10(10): PMID: 34066048, PMCID: PMC8150905, PII: jcm10102076, DOI: 10.3390/jcm10102076, ISSN: 2077-0383.
Bastarache JA, McNeil JB, Plosa EJ, Sucre JS, Kerchberger VE, Habegger LE, Weddle E, Sullivan B, Meegan JE, Wickersham NE, Shaver CM, Ware LB. Standardization of methods for sampling the distal airspace in mechanically ventilated patients using heat moisture exchange filter fluid. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2021 May 5/1/2021; 320(5): L785-L790-L790. PMID: 33655765, PMCID: PMC8174823, DOI: 10.1152/ajplung.00595.2020, ISSN: 1522-1504.
Yu WK, McNeil JB, Wickersham NE, Shaver CM, Bastarache JA, Ware LB. Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure. Crit Care. 2021 Feb 2/4/2021; 25(1): 48. PMID: 33541396, PMCID: PMC7859898, PII: 10.1186/s13054-021-03474-z, DOI: 10.1186/s13054-021-03474-z, ISSN: 1466-609X.
Chen HH, Shaw DM, Petty LE, Graff M, Bohlender RJ, Polikowsky HG, Zhong X, Kim D, Buchanan VL, Preuss MH, Shuey MM, Loos RJF, Huff CD, Cox NJ, Bastarache JA, Bastarache L, North KE, Below JE. Host genetic effects in pneumonia. Am J Hum Genet [print-electronic]. 2021 Jan 1/7/2021; 108(1): 194-201. PMID: 33357513, PMCID: PMC7820802, PII: S0002-9297(20)30446-8, DOI: 10.1016/j.ajhg.2020.12.010, ISSN: 1537-6605.
Summers ME, Richmond BW, Kropski JA, Majka SA, Bastarache JA, Hatzopoulos AK, Bylund J, Ghosh M, Petrache I, Foronjy RF, Geraghty P, Majka SM. Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function. Am J Physiol Cell Physiol [print-electronic]. 2021 Jan 1/1/2021; 320(1): C119-C131-C131. PMID: 33085496, PMCID: PMC7846975, DOI: 10.1152/ajpcell.00277.2020, ISSN: 1522-1563.
Jabaudon M, Audard J, Pereira B, Jaber S, Lefrant JY, Blondonnet R, Godet T, Futier E, Lambert C, Bazin JE, Bastarache JA, Constantin JM, Ware LB, . Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS. Chest [print-electronic]. 2020 Dec; 158(6): 2394-403. PMID: 32659235, PMCID: PMC7768934, PII: S0012-3692(20)31874-2, DOI: 10.1016/j.chest.2020.06.070, ISSN: 1931-3543.
Shaver CM, Landstreet SR, Pugazenthi S, Scott F, Putz N, Ware LB, Bastarache JA. The NLRP3 inflammasome in macrophages is stimulated by cell-free hemoglobin. Physiol Rep. 2020 Nov; 8(21): e14589. PMID: 33128438, PMCID: PMC7601531, DOI: 10.14814/phy2.14589, ISSN: 2051-817X.
Bastarache JA. The future of sepsis research: time to think differently? [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2020 Sep 9/1/2020; 319(3): L523-L526-L526. PMID: 32755382, PMCID: PMC7518062, DOI: 10.1152/ajplung.00368.2020, ISSN: 1522-1504.
Summers ME, Richmond BW, Menon S, Sheridan RM, Kropski JA, Majka SA, Taketo MM, Bastarache JA, West JD, De Langhe S, Geraghty P, Klemm DJ, Chu HW, Friedman RS, Tao YK, Foronjy RF, Majka SM. Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling. FASEB J [print-electronic]. 2020 Aug; 34(8): 10267-85. PMID: 32533805, PMCID: PMC7496763, DOI: 10.1096/fj.202000629R, ISSN: 1530-6860.
Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM, Jabaudon M, . Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. Respir Res. 2020 Apr 4/7/2020; 21(1): 81. PMID: 32264897, PMCID: PMC7137453, PII: 10.1186/s12931-020-01337-9, DOI: 10.1186/s12931-020-01337-9, ISSN: 1465-993X.
Jabaudon M, Bastarache JA, Ware LB. Eyes wide open on bronchial aeration in acute respiratory distress syndrome [editorial]. Anaesth Crit Care Pain Med [print-electronic]. 2020 Apr; 39(2): 191-2. PMID: 32145431, PII: S2352-5568(20)30035-7, DOI: 10.1016/j.accpm.2020.03.003, ISSN: 2352-5568.
Willen SM, McNeil JB, Rodeghier M, Kerchberger VE, Shaver CM, Bastarache JA, Steinberg MH, DeBaun MR, Ware LB. Haptoglobin genotype predicts severe acute vaso-occlusive pain episodes in children with sickle cell anemia [letter]. Am J Hematol [print-electronic]. 2020 Apr; 95(4): E92-E95-E95. PMID: 31919880, PMCID: PMC7343605, DOI: 10.1002/ajh.25728, ISSN: 1096-8652.
Consoli DC, Jesse JJ, Klimo KR, Tienda AA, Putz ND, Bastarache JA, Harrison FE. A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain. Nutrients. 2020 Mar 3/26/2020; 12(4): PMID: 32224930, PMCID: PMC7231213, PII: nu12040911, DOI: 10.3390/nu12040911, ISSN: 2072-6643.
Meegan JE, Shaver CM, Putz ND, Jesse JJ, Landstreet SR, Lee HNR, Sidorova TN, McNeil JB, Wynn JL, Cheung-Flynn J, Komalavilas P, Brophy CM, Ware LB, Bastarache JA. Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis. PLoS One. 2020; 15(2): e0228727. PMID: 32012200, PMCID: PMC6996826, PII: PONE-D-19-12903, DOI: 10.1371/journal.pone.0228727, ISSN: 1932-6203.
Kerchberger VE, Huang Y, Koyama T, Shoemaker MB, Darbar D, Bastarache JA, Ware LB, Shaver CM. Clinical and Genetic Contributors to New-Onset Atrial Fibrillation in Critically Ill Adults. Crit Care Med. 2020 Jan; 48(1): 22-30. PMID: 31599812, PMCID: PMC6910934, DOI: 10.1097/CCM.0000000000004034, ISSN: 1530-0293.
Kerchberger VE, Bastarache JA, Shaver CM, Nagata H, McNeil JB, Landstreet SR, Putz ND, Yu WK, Jesse J, Wickersham NE, Sidorova TN, Janz DR, Parikh CR, Siew ED, Ware LB. Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis. JCI Insight. 2019 Nov 11/1/2019; 4(21): PMID: 31573976, PMCID: PMC6948757, PII: 131206, DOI: 10.1172/jci.insight.131206, ISSN: 2379-3708.
Shaver CM, Paul MG, Putz ND, Landstreet SR, Kuck JL, Scarfe L, Skrypnyk N, Yang H, Harrison FE, de Caestecker MP, Bastarache JA, Ware LB. Cell-free hemoglobin augments acute kidney injury during experimental sepsis. Am J Physiol Renal Physiol [print-electronic]. 2019 Oct 10/1/2019; 317(4): F922-F929-F929. PMID: 31364379, PMCID: PMC6843044, DOI: 10.1152/ajprenal.00375.2018, ISSN: 1522-1466.
Bastarache L, Bastarache JA, Denny JC. Case 40-2018: A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis [letter]. N Engl J Med. 2019 Apr 4/4/2019; 380(14): 1382-3. PMID: 30943357, PMCID: PMC10507791, PII: 10.1056/NEJMc1901268#sa1, DOI: 10.1056/NEJMc1901268, ISSN: 1533-4406.
Yu WK, McNeil JB, Wickersham NE, Shaver CM, Bastarache JA, Ware LB. Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury. Crit Care. 2019 Jan 1/18/2019; 23(1): 18. PMID: 30658667, PMCID: PMC6339439, PII: 10.1186/s13054-019-2315-y, DOI: 10.1186/s13054-019-2315-y, ISSN: 1466-609X.
McPeake J, Hirshberg EL, Christie LM, Drumright K, Haines K, Hough CL, Meyer J, Wade D, Andrews A, Bakhru R, Bates S, Barwise JA, Bastarache J, Beesley SJ, Boehm LM, Brown S, Clay AS, Firshman P, Greenberg S, Harris W, Hill C, Hodgson C, Holdsworth C, Hope AA, Hopkins RO, Howell DCJ, Janssen A, Jackson JC, Johnson A, Kross EK, Lamas D, MacLeod-Smith B, Mandel R, Marshall J, Mikkelsen ME, Nackino M, Quasim T, Sevin CM, Slack A, Spurr R, Still M, Thompson C, Weinhouse G, Wilcox ME, Iwashyna TJ. Models of Peer Support to Remediate Post-Intensive Care Syndrome: A Report Developed by the Society of Critical Care Medicine Thrive International Peer Support Collaborative. Crit Care Med. 2019 Jan; 47(1): e21-e27-e27. PMID: 30422863, PMCID: PMC6719778, DOI: 10.1097/CCM.0000000000003497, ISSN: 1530-0293.
Bloodworth NC, Clark CR, West JD, Snider JC, Gaskill C, Shay S, Scott C, Bastarache J, Gladson S, Moore C, D'Amico R, Brittain EL, Tanjore H, Blackwell TS, Majka SM, Merryman WD. Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism. Circ Res. 2018 Dec 12/7/2018; 123(12): e51-e64-e64. PMID: 30566041, PMCID: PMC6309812, DOI: 10.1161/CIRCRESAHA.118.313397, ISSN: 1524-4571.
Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax [print-electronic]. 2018 Sep; 73(9): 840-6. PMID: 29903755, PMCID: PMC6410734, PII: thoraxjnl-2017-211280, DOI: 10.1136/thoraxjnl-2017-211280, ISSN: 1468-3296.
Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 Sep; 59(3): 363-74. PMID: 29584451, PMCID: PMC6189644, DOI: 10.1165/rcmb.2017-0428OC, ISSN: 1535-4989.
McNeil JB, Shaver CM, Kerchberger VE, Russell DW, Grove BS, Warren MA, Wickersham NE, Ware LB, McDonald WH, Bastarache JA. Novel Method for Noninvasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Apr 4/15/2018; 197(8): 1027-35. PMID: 29253353, PMCID: PMC5909163, DOI: 10.1164/rccm.201707-1474OC, ISSN: 1535-4970.
Putz ND, Shaver CM, Dufu K, Li CM, Xu Q, Hutchaleelaha A, Lehrer-Graiwer J, Majka SM, Ware LB, Bastarache JA. GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival in murine hypoxic acute lung injury. J Appl Physiol (1985) [print-electronic]. 2018 Apr 4/1/2018; 124(4): 899-905. PMID: 29357510, PMCID: PMC7002864, DOI: 10.1152/japplphysiol.00079.2017, ISSN: 1522-1601.
Shaver CM, Wickersham N, McNeil JB, Nagata H, Miller A, Landstreet SR, Kuck JL, Diamond JM, Lederer DJ, Kawut SM, Palmer SM, Wille KM, Weinacker A, Lama VN, Crespo MM, Orens JB, Shah PD, Hage CA, Cantu E, Porteous MK, Dhillon G, McDyer J, Bastarache JA, Christie JD, Ware LB, . Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury. JCI Insight. 2018 Jan 1/25/2018; 3(2): PMID: 29367464, PMCID: PMC5821179, PII: 98546, DOI: 10.1172/jci.insight.98546, ISSN: 2379-3708.
Kuck JL, Bastarache JA, Shaver CM, Fessel JP, Dikalov SI, May JM, Ware LB. Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. Biochem Biophys Res Commun [print-electronic]. 2018 Jan 1/1/2018; 495(1): 433-7. PMID: 29129689, PMCID: PMC5736437, PII: S0006-291X(17)32236-2, DOI: 10.1016/j.bbrc.2017.11.058, ISSN: 1090-2104.
DesPrez K, McNeil JB, Wang C, Bastarache JA, Shaver CM, Ware LB. Oxygenation Saturation Index Predicts Clinical Outcomes in ARDS. Chest [print-electronic]. 2017 Dec; 152(6): 1151-8. PMID: 28823812, PMCID: PMC5812755, PII: S0012-3692(17)31395-8, DOI: 10.1016/j.chest.2017.08.002, ISSN: 1931-3543.
Casey JD, Semler MW, Bastarache JA. Aspirin for Sepsis Prophylaxis: An Ounce of Prevention? [editorial]. Crit Care Med. 2017 Nov; 45(11): 1959-60. PMID: 29028704, PMCID: PMC5658041, PII: 00003246-201711000-00028, DOI: 10.1097/CCM.0000000000002669, ISSN: 1530-0293.
Murphy LS, Wickersham N, McNeil JB, Shaver CM, May AK, Bastarache JA, Ware LB. Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction. Ann Intensive Care. 2017 Oct 10/6/2017; 7(1): 102. PMID: 28986821, PMCID: PMC5630541, PII: 10.1186/s13613-017-0325-y, DOI: 10.1186/s13613-017-0325-y, ISSN: 2110-5820.
Zheng NS, Bastarache LA, Bastarache JA, Lu Y, Ware LB, Shu XO, Denny JC, Long J. A common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women. J Hum Genet [print-electronic]. 2017 Oct; 62(10): 911-4. PMID: 28659611, PMCID: PMC5824713, PII: jhg201766, DOI: 10.1038/jhg.2017.66, ISSN: 1435-232X.
Shaver CM, Wickersham N, McNeil JB, Nagata H, Sills G, Kuck JL, Janz DR, Bastarache JA, Ware LB. Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3): S251-S252-S252. PMID: 28945473, PMCID: PMC5711346, DOI: 10.1513/AnnalsATS.201609-693MG, ISSN: 2325-6621.
Shaver CM, Woods J, Clune JK, Grove BS, Wickersham NE, McNeil JB, Shemancik G, Ware LB, Bastarache JA. Circulating microparticle levels are reduced in patients with ARDS. Crit Care. 2017 May 5/25/2017; 21(1): 120. PMID: 28545548, PMCID: PMC5445431, PII: 10.1186/s13054-017-1700-7, DOI: 10.1186/s13054-017-1700-7, ISSN: 1466-609X.
Luo L, Shaver CM, Zhao Z, Koyama T, Calfee CS, Bastarache JA, Ware LB. Clinical Predictors of Hospital Mortality Differ Between Direct and Indirect ARDS. Chest [print-electronic]. 2017 Apr; 151(4): 755-63. PMID: 27663180, PMCID: PMC5472517, PII: S0012-3692(16)59167-3, DOI: 10.1016/j.chest.2016.09.004, ISSN: 1931-3543.
Tatsumi K, Antoniak S, Subramaniam S, Gondouin B, Neidich SD, Beck MA, Mickelson J, Monroe DM, Bastarache JA, Mackman N. Anticoagulation increases alveolar hemorrhage in mice infected with influenza A. Physiol Rep. 2016 Dec; 4(24): PMID: 28003564, PMCID: PMC5210384, PII: 4/24/e13071, DOI: 10.14814/phy2.13071, ISSN: 2051-817X.
Rondina MT, Tatsumi K, Bastarache JA, Mackman N. Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection. Crit. Care Med. 2016 Jul; 44(7): e574-8. PMID: 26751613, PMCID: PMC4911267, DOI: 10.1097/CCM.0000000000001584, ISSN: 1530-0293.
Antoniak S, Tatsumi K, Hisada Y, Milner JJ, Neidich SD, Shaver CM, Pawlinski R, Beck MA, Bastarache JA, Mackman N. Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice. J. Thromb. Haemost [print-electronic]. 2016 Jun; 14(6): 1238-48. PMID: 26947929, DOI: 10.1111/jth.13307, ISSN: 1538-7836.
Bastarache JA, Seeley EJ. Sepsis [editorial]. Clin. Chest Med. 2016 Jun; 37(2): xv-xvi. PMID: 27229652, PII: S0272-5231(16)30025-9, DOI: 10.1016/j.ccm.2016.04.001, ISSN: 1557-8216.
Shaver CM, Upchurch CP, Janz DR, Grove BS, Putz ND, Wickersham NE, Dikalov SI, Ware LB, Bastarache JA. Cell-free hemoglobin: a novel mediator of acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Mar 3/15/2016; 310(6): L532-41. PMID: 26773065, PMCID: PMC4796260, PII: ajplung.00155.2015, DOI: 10.1152/ajplung.00155.2015, ISSN: 1522-1504.
Shaver CM, Grove BS, Clune JK, Mackman N, Ware LB, Bastarache JA. Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury. Sci Rep. 2016; 6: 22249. PMID: 26924425, PMCID: PMC4770302, PII: srep22249, DOI: 10.1038/srep22249, ISSN: 2045-2322.
Chen W, Janz DR, Shaver CM, Bernard GR, Bastarache JA, Ware LB. Clinical Characteristics and Outcomes Are Similar in ARDS Diagnosed by Oxygen Saturation/Fio2 Ratio Compared With Pao2/Fio2 Ratio. Chest. 2015 Dec; 148(6): 1477-83. PMID: 26271028, PMCID: PMC4665739, PII: S0012-3692(15)50112-8, DOI: 10.1378/chest.15-0169, ISSN: 1931-3543.
Shaver CM, Grove BS, Putz ND, Clune JK, Lawson WE, Carnahan RH, Mackman N, Ware LB, Bastarache JA. Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor. Am. J. Respir. Cell Mol. Biol. 2015 Nov; 53(5): 719-27. PMID: 25884207, PMCID: PMC4742948, DOI: 10.1165/rcmb.2014-0179OC, ISSN: 1535-4989.
Shaver CM, Chen W, Janz DR, May AK, Darbar D, Bernard GR, Bastarache JA, Ware LB. Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit. Care Med. 2015 Oct; 43(10): 2104-11. PMID: 26154932, PMCID: PMC4725582, DOI: 10.1097/CCM.0000000000001166, ISSN: 1530-0293.
Chen W, Janz DR, Bastarache JA, May AK, O'Neal HR, Bernard GR, Ware LB. Prehospital aspirin use is associated with reduced risk of acute respiratory distress syndrome in critically ill patients: a propensity-adjusted analysis. Crit. Care Med. 2015 Apr; 43(4): 801-7. PMID: 25559436, PMCID: PMC4359645, DOI: 10.1097/CCM.0000000000000789, ISSN: 1530-0293.
Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ, Ware LB, . Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. Crit. Care Med. 2015 Mar; 43(3): 534-41. PMID: 25474535, PMCID: PMC4336619, DOI: 10.1097/CCM.0000000000000718, ISSN: 1530-0293.
Bastarache JA, Wynn JL, Ware LB. Fanning the Fire: Can Methemoglobin Enhance Neutrophil Activation?. EBioMedicine. 2015 Mar; 2(3): 184-5. PMID: 26137557, PMCID: PMC4485487, PII: S2352-3964(15)00043-2, DOI: 10.1016/j.ebiom.2015.01.019, ISSN: 2352-3964.
Ware LB, Bastarache JA, Calfee CS. ARDS: new mechanistic insights, new therapeutic directions [editorial]. Clin. Chest Med [print-electronic]. 2014 Dec; 35(4): xv-xvi. PMID: 25453428, PII: S0272-5231(14)00086-0, DOI: 10.1016/j.ccm.2014.09.001, ISSN: 1557-8216.
Shaver CM, Bastarache JA. Clinical and biological heterogeneity in acute respiratory distress syndrome: direct versus indirect lung injury. Clin. Chest Med [print-electronic]. 2014 Dec; 35(4): 639-53. PMID: 25453415, PMCID: PMC4254695, PII: S0272-5231(14)00073-2, DOI: 10.1016/j.ccm.2014.08.004, ISSN: 1557-8216.
Brittain EL, Janz DR, Austin ED, Bastarache JA, Wheeler LA, Ware LB, Hemnes AR. Elevation of plasma cell-free hemoglobin in pulmonary arterial hypertension. Chest. 2014 Dec; 146(6): 1478-85. PMID: 24945582, PMCID: PMC4251612, PII: S0012-3692(15)51517-1, DOI: 10.1378/chest.14-0809, ISSN: 1931-3543.
Bastarache JA, Koyama T, Wickersham NE, Ware LB. Validation of a multiplex electrochemiluminescent immunoassay platform in human and mouse samples. J. Immunol. Methods [print-electronic]. 2014 Jun; 408: 13-23. PMID: 24768796, PMCID: PMC4120713, PII: S0022-1759(14)00123-9, DOI: 10.1016/j.jim.2014.04.006, ISSN: 1872-7905.
Bastarache JA, Roberts LJ, Ware LB. Thinking outside the cell: how cell-free hemoglobin can potentiate acute lung injury [editorial]. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2014 Feb; 306(3): L231-2. PMID: 24337924, PMCID: PMC3920200, PII: ajplung.00355.2013, DOI: 10.1152/ajplung.00355.2013, ISSN: 1522-1504.
Richmond BW, Worrell JA, Bastarache JA, Gervich DH, Slattery WR, Loyd JE. Histoplasmomas of uncommon size. Chest. 2013 Jun; 143(6): 1795-8. PMID: 23732591, PII: S0012-3692(13)60414-6, DOI: 10.1378/chest.12-2071, ISSN: 1931-3543.
Sebag SC, Bastarache JA, Ware LB. Mechanical stretch inhibits lipopolysaccharide-induced keratinocyte-derived chemokine and tissue factor expression while increasing procoagulant activity in murine lung epithelial cells. J. Biol. Chem [print-electronic]. 2013 Mar 3/15/2013; 288(11): 7875-84. PMID: 23362270, PMCID: PMC3597825, PII: M112.403220, DOI: 10.1074/jbc.M112.403220, ISSN: 1083-351X.
Janz DR, Bastarache JA, Peterson JF, Sills G, Wickersham N, May AK, Roberts LJ, Ware LB. Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. Crit. Care Med. 2013 Mar; 41(3): 784-90. PMID: 23314583, PMCID: PMC3578977, DOI: 10.1097/CCM.0b013e3182741a54, ISSN: 1530-0293.
Janz DR, Zhao Z, Koyama T, May AK, Bernard GR, Bastarache JA, Young PP, Ware LB. Longer storage duration of red blood cells is associated with an increased risk of acute lung injury in patients with sepsis. Ann Intensive Care. 2013; 3(1): 33. PMID: 24059842, PMCID: PMC3848804, PII: 2110-5820-3-33, DOI: 10.1186/2110-5820-3-33, ISSN: 2110-5820.
Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N, Ware LB. Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax [print-electronic]. 2012 Dec; 67(12): 1032-9. PMID: 23033361, PMCID: PMC3652432, PII: thoraxjnl-2012-201781, DOI: 10.1136/thoraxjnl-2012-201781, ISSN: 1468-3296.
Bastarache JA, Ware LB, Girard TD, Wheeler AP, Rice TW. Markers of inflammation and coagulation may be modulated by enteral feeding strategy. JPEN J Parenter Enteral Nutr [print-electronic]. 2012 Nov; 36(6): 732-40. PMID: 22318965, PMCID: PMC3726194, PII: 0148607111433054, DOI: 10.1177/0148607111433054, ISSN: 0148-6071.
Zeyed YF, Bastarache JA, Matthay MA, Ware LB. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Sep 9/15/2012; 303(6): L550-5. PMID: 22821995, PMCID: PMC3468480, PII: ajplung.00190.2012, DOI: 10.1152/ajplung.00190.2012, ISSN: 1522-1504.
Bastarache JA, Diamond JM, Kawut SM, Lederer DJ, Ware LB, Christie JD. Postoperative estradiol levels associate with development of primary graft dysfunction in lung transplantation patients. Gend Med [print-electronic]. 2012 Jun; 9(3): 154-65. PMID: 22361838, PMCID: PMC3374892, PII: S1550-8579(12)00049-6, DOI: 10.1016/j.genm.2012.01.009, ISSN: 1878-7398.
Bastarache JA, Sebag SC, Grove BS, Ware LB. Interferon-¿ and tumor necrosis factor-a act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp. Lung Res. 2011 Oct; 37(8): 509-17. PMID: 21913843, PMCID: PMC3652424, DOI: 10.3109/01902148.2011.605512, ISSN: 1521-0499.
Sebag SC, Bastarache JA, Ware LB. Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome. Curr Pharm Biotechnol. 2011 Sep; 12(9): 1481-96. PMID: 21401517, PMCID: PMC3893117, PII: BSP/CPB/E-Pub/000104-12-9, ISSN: 1873-4316.
Bastarache JA, Ong T, Matthay MA, Ware LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Crit Care [print-electronic]. 2011 Jun; 26(3): 249-56. PMID: 20688464, PMCID: PMC2982881, PII: S0883-9441(10)00168-1, DOI: 10.1016/j.jcrc.2010.06.005, ISSN: 1557-8615.
Bastarache JA, Koyama T, Wickersham NE, Mitchell DB, Mernaugh RL, Ware LB. Accuracy and reproducibility of a multiplex immunoassay platform: a validation study. J. Immunol. Methods [print-electronic]. 2011 Mar 3/31/2011; 367(1-2): 33-9. PMID: 21277854, PMCID: PMC3108329, PII: S0022-1759(11)00008-1, DOI: 10.1016/j.jim.2011.01.005, ISSN: 1872-7905.
Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur. Respir. J [print-electronic]. 2010 Feb; 35(2): 331-7. PMID: 19741024, PMCID: PMC2819058, PII: 09031936.00098709, DOI: 10.1183/09031936.00098709, ISSN: 1399-3003.
Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB. Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2009 Dec; 297(6): L1035-41. PMID: 19700643, PMCID: PMC2793184, PII: 00214.2009, DOI: 10.1152/ajplung.00214.2009, ISSN: 1522-1504.
Bastarache JA, Blackwell TS. Development of animal models for the acute respiratory distress syndrome. Dis Model Mech. 2009 May; 2(5-6): 218-23. PMID: 19407329, PMCID: PMC2675821, PII: 2/5-6/218, DOI: 10.1242/dmm.001677, ISSN: 1754-8411.
Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 May; 294(5): L874-81. PMID: 18310227, PMCID: PMC2764534, PII: 00372.2007, DOI: 10.1152/ajplung.00372.2007, ISSN: 1040-0605.
Wang L, Bastarache JA, Ware LB. The coagulation cascade in sepsis. Curr. Pharm. Des. 2008; 14(19): 1860-9. PMID: 18691097, ISSN: 1873-4286.
Worrell JA, Donnelly EF, Martin JB, Bastarache JA, Loyd JE. Computed tomography and the idiopathic form of proliferative fibrosing mediastinitis. J Thorac Imaging. 2007 Aug; 22(3): 235-40. PMID: 17721332, PII: 00005382-200708000-00004, DOI: 10.1097/01.rti.0000213589.29472.18, ISSN: 0883-5993.
Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax [print-electronic]. 2007 Jul; 62(7): 608-16. PMID: 17356058, PMCID: PMC2117249, PII: thx.2006.063305, DOI: 10.1136/thx.2006.063305, ISSN: 0040-6376.
Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2007 Apr; 36(4): 497-503. PMID: 17099142, PMCID: PMC1899324, PII: 2005-0425OC, DOI: 10.1165/rcmb.2005-0425OC, ISSN: 1044-1549.
Bastarache JA, Ware LB, Bernard GR. The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome. Semin Respir Crit Care Med. 2006 Aug; 27(4): 365-76. PMID: 16909370, DOI: 10.1055/s-2006-948290, ISSN: 1069-3424.
Ware LB, Bastarache JA, Wang L. Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?. Keio J Med. 2005 Sep; 54(3): 142-9. PMID: 16237276, ISSN: 0022-9717.
Eichelberger KR, Podar NA, Mei JA, Curry JM, Chandrasekaran R, Paul S, Bastarache JA, Torres VJ, Peters BM, Cassat JE. Candida albicans activates Staphylococcus aureus virulence regulatory systems to drive toxin-mediated human cell death. BioRxiv. 2025 Oct 10/3/2025; PMID: 41256409, PMCID: PMC12621760, PII: 2025.10.03.680095, DOI: 10.1101/2025.10.03.680095, ISSN: 2692-8205.
Shimoda LA, Alvira CM, Bastarache JA, Britt RD, Knipe RS, Kuebler WM, Moreira TS, Schmidt EP. Opportunity knocks: the fourth cohort of the American Journal of Physiology-Lung Cellular and Molecular Physiology Early Career Editorial Fellowship Program [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2025 Sep 9/1/2025; 329(3): L324-L326-L326. PMID: 40701621, DOI: 10.1152/ajplung.00238.2025, ISSN: 1522-1504.
Sanchez PA, Obeidalla S, Kerchberger VE, Moore AR, Maddali MV, Kangelaris KN, Hendrickson CM, Evrard B, Liu KD, Bastarache JA, Matthay MA, Rogers AJ, Calfee CS. Heterogeneity in association of myocardial injury and mortality in sepsis or acute respiratory distress syndrome by subphenotype: a retrospective study. Crit Care. 2025 Aug 8/19/2025; 29(1): 363. PMID: 40826103, PMCID: PMC12363128, PII: 10.1186/s13054-025-05613-2, DOI: 10.1186/s13054-025-05613-2, ISSN: 1466-609X.
Lee HNR, Lin J, Smith CJ, Ware LB, Harrison FE, Bastarache JA, Baer B. Advanced Age in Mice Exacerbates Sepsis-Induced Inflammation, Vascular Permeability, and Multi-Organ Dysfunction. Shock [print-electronic]. 2025 Jun 6/26/2025; PMID: 40668087, PII: 00024382-990000000-00698, DOI: 10.1097/SHK.0000000000002657, ISSN: 1540-0514.
Riedmann KJ, Meegan JE, Afzal A, Cervantes-Cruz Y, Obeidalla S, Bogart AM, Ware LB, Shaver CM, Bastarache JA. Oxidized Cell-Free Hemoglobin Induces Mitochondrial Dysfunction by Activation of the Mitochondrial Permeability Transition Pore in the Pulmonary Microvasculature. Microcirculation. 2025 May; 32(4): e70012. PMID: 40394906, PMCID: PMC12093041, DOI: 10.1111/micc.70012, ISSN: 1549-8719.
Meegan JE, Riedmann KJ, Gonski S, Douglas JS, Bogart AM, Ware LB, Bastarache JA. Oxidation of low-density lipoprotein by hemoglobin causes pulmonary microvascular endothelial barrier dysfunction through lectin-like oxidized LDL receptor 1. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2025 May 5/1/2025; 328(5): L748-L755-L755. PMID: 40249953, PMCID: PMC12117588, DOI: 10.1152/ajplung.00026.2025, ISSN: 1522-1504.
Shimoda LA, Bastarache JA, Britt RD, Kuebler WM. Every breath you take: exploring macrophages and environmental exposures in the lung-a tribute to Dr. Joseph Brain's legacy [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2025 Mar 3/1/2025; 328(3): L321-L323-L323. PMID: 39823196, DOI: 10.1152/ajplung.00407.2024, ISSN: 1522-1504.
Stier MT, Sewell AE, Mwizerwa EL, Sim CY, Tanner SM, Nichols CM, Durai HH, Jennings EQ, Lindau P, Wilfong EM, Newcomb DC, Bastarache JA, Ware LB, Rathmell JC. Metabolic Adaptations Rewire CD4 T Cells in a Subset-Specific Manner in Human Critical Illness with and without Sepsis. BioRxiv. 2025 Jan 1/29/2025; PMID: 39975258, PMCID: PMC11838299, PII: 2025.01.27.635146, DOI: 10.1101/2025.01.27.635146, ISSN: 2692-8205.
Baer B, Lin J, Schaaf KR, Ware LB, Shaver CM, Bastarache JA. Matrix metalloproteinase-7 is dispensable in a mouse model of sepsis-induced acute lung injury. PLoS One. 2025; 20(5): e0321349. PMID: 40341670, PMCID: PMC12061409, PII: PONE-D-24-46782, DOI: 10.1371/journal.pone.0321349, ISSN: 1932-6203.
Meegan JE, Rizzo AN, Schmidt EP, Bastarache JA. Cellular Mechanisms of Lung Injury: Current Perspectives. Clin Chest Med [print-electronic]. 2024 Dec; 45(4): 821-33. PMID: 39443000, PMCID: PMC11499619, PII: S0272-5231(24)00066-2, DOI: 10.1016/j.ccm.2024.08.004, ISSN: 1557-8216.
Bogart AM, Lopez CR, Obeidalla SN, Wang C, Willmore A, Jauregui A, Kangelaris KN, Hendrickson C, Gomez A, Liu KD, Matthay MA, Shaver CM, Bastarache JA, Calfee CS, Kerchberger VE, Ware LB. Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies. CHEST Crit Care [print-electronic]. 2024 Sep; 2(3): PMID: 39421542, PMCID: PMC11485198, PII: 100082, DOI: 10.1016/j.chstcc.2024.100082, ISSN: 2949-7884.
Murphy MB, Yang Z, Subati T, Farber-Eger E, Kim K, Blackwell DJ, Fleming MR, Stark JM, Van Amburg JC, Woodall KK, Van Beusecum JP, Agrawal V, Smart CD, Pitzer A, Atkinson JB, Fogo AB, Bastarache JA, Kirabo A, Wells QS, Madhur MS, Barnett JV, Murray KT. LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation. Cardiovasc Res. 2024 Jul 7/2/2024; 120(8): 899-913. PMID: 38377486, PMCID: PMC11218690, PII: 7611672, DOI: 10.1093/cvr/cvae036, ISSN: 1755-3245.
Kuhar E, Chander N, Stewart DJ, Jahandideh F, Zhang H, Kristof AS, Bastarache JA, Schmidt EP, Taljaard M, Thebaud B, Engelberts D, Fergusson DA, Lalu MM. A preclinical systematic review and meta-analysis assessing the effect of biological sex in lipopolysaccharide-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2024 Jun 6/1/2024; 326(6): L661-L671-L671. PMID: 38349120, PMCID: PMC11905864, DOI: 10.1152/ajplung.00336.2023, ISSN: 1522-1504.
Matthay MA, Schmidt EP, Bastarache JA, Calfee CS, Frevert CW, Martin TR. The Translational Value of Rodent Models of Sepsis. Am J Respir Crit Care Med. 2024 Mar 3/1/2024; 209(5): 488-90. PMID: 38091521, PMCID: PMC10919117, DOI: 10.1164/rccm.202308-1489VP, ISSN: 1535-4970.
Zehr EP, Erzen CL, Oshima K, Langouet-Astrie CJ, LaRiviere WB, Shi D, Zhang F, McCollister BD, Windham SL, Rizzo AN, Bastarache JA, Horswill AR, Schmidt EP, Kwiecinski JM, Colbert JF. Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2024 Feb 2/1/2024; 326(2): L206-L212-L212. PMID: 38113313, PMCID: PMC11280675, DOI: 10.1152/ajplung.00178.2023, ISSN: 1522-1504.
Schaaf KR, Landstreet SR, Putz ND, Gonski SK, Lin J, Buggs CJ, Gibson D, Langouët-Astrié CJ, Jetter CS, Negretti NM, Sucre JMS, Schmidt EP, Ware LB, Bastarache JA, Shaver CM. Matrix metalloproteinases mediate influenza A-associated shedding of the alveolar epithelial glycocalyx. PLoS One. 2024; 19(9): e0308648. PMID: 39312544, PMCID: PMC11419339, PII: PONE-D-24-21637, DOI: 10.1371/journal.pone.0308648, ISSN: 1932-6203.
Schaaf KR, Landstreet SR, Pugazenthi S, Qian EY, Putz ND, Siderova T, Owen AM, Bohannon JK, Ware LB, Bastarache JA, Shaver CM. Cell-free hemoglobin triggers macrophage cytokine production via TLR4 and MyD88. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2024 Jan 1/1/2024; 326(1): L29-L38-L38. PMID: 37991487, PMCID: PMC11279742, DOI: 10.1152/ajplung.00123.2023, ISSN: 1522-1504.
Bain W, Bastarache JA, Sarma A, McElvaney NG, Baron RM, McVerry BJ, Kitsios GD. Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs [letter]. Ann Am Thorac Soc. 2024 Jan; 21(1): 183-4. PMID: 37776282, PMCID: PMC10867904, DOI: 10.1513/AnnalsATS.202306-589LE, ISSN: 2325-6621.
Bejoy J, Farry JM, Qian ES, Dearing CH, Ware LB, Bastarache JA, Woodard LE. Ascorbate protects human kidney organoids from damage induced by cell-free hemoglobin. Dis Model Mech [print-electronic]. 2023 Dec 12/1/2023; 16(12): PMID: 37942584, PMCID: PMC10695115, PII: 334691, DOI: 10.1242/dmm.050342, ISSN: 1754-8411.
Shuey MM, Stead WW, Aka I, Barnado AL, Bastarache JA, Brokamp E, Campbell M, Carroll RJ, Goldstein JA, Lewis A, Malow BA, Mosley JD, Osterman T, Padovani-Claudio DA, Ramirez A, Roden DM, Schuler BA, Siew E, Sucre J, Thomsen I, Tinker RJ, Van Driest S, Walsh C, Warner JL, Wells QS, Wheless L, Bastarache L. Next-generation phenotyping: introducing phecodeX for enhanced discovery research in medical phenomics. Bioinformatics. 2023 Nov 11/1/2023; 39(11): PMID: 37930895, PMCID: PMC10627409, PII: 7335839, DOI: 10.1093/bioinformatics/btad655, ISSN: 1367-4811.
Goodman RS, Patrinely JR, Stone CA, Zimmerman E, Donald RR, Chang SS, Berkowitz ST, Finn AP, Jahangir E, Scoville EA, Reese TS, Friedman DL, Bastarache JA, van der Heijden YF, Wright JJ, Ye F, Carter N, Alexander MR, Choe JH, Chastain CA, Zic JA, Horst SN, Turker I, Agarwal R, Osmundson E, Idrees K, Kiernan CM, Padmanabhan C, Bailey CE, Schlegel CE, Chambless LB, Gibson MK, Osterman TJ, Wheless LE, Johnson DB. Accuracy and Reliability of Chatbot Responses to Physician Questions. JAMA Netw Open. 2023 Oct 10/2/2023; 6(10): e2336483. PMID: 37782499, PMCID: PMC10546234, PII: 2809975, DOI: 10.1001/jamanetworkopen.2023.36483, ISSN: 2574-3805.
Baer B, Putz ND, Riedmann K, Gonski S, Lin J, Ware LB, Toki S, Peebles RS, Cahill KN, Bastarache JA. Liraglutide pretreatment attenuates sepsis-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2023 Sep 9/1/2023; 325(3): L368-L384-L384. PMID: 37489855, PMCID: PMC10639010, DOI: 10.1152/ajplung.00041.2023, ISSN: 1522-1504.
Pandharipande P, Williams Roberson S, Harrison FE, Wilson JE, Bastarache JA, Ely EW. Mitigating neurological, cognitive, and psychiatric sequelae of COVID-19-related critical illness. Lancet Respir Med [print-electronic]. 2023 Aug; 11(8): 726-38. PMID: 37475124, PMCID: PMC10706757, PII: S2213-2600(23)00238-2, DOI: 10.1016/S2213-2600(23)00238-2, ISSN: 2213-2619.
Davis A, Johnson DB, Bastarache JA. Long-term outcomes in patients with immune checkpoint inhibitor induced pneumonitis. BMJ Open Respir Res. 2023 Apr 4/6/2023; 10(1): PMID: 40042935, PMCID: PMC10083847, PII: 10/1/e001342, DOI: 10.1136/bmjresp-2022-001342, ISSN: 2052-4439.
Conger AK, Tomasek T, Riedmann KJ, Douglas JS, Berkey LE, Ware LB, Bastarache JA, Meegan JE. Hemoglobin increases leukocyte adhesion and initiates lung microvascular endothelial activation via Toll-like receptor 4 signaling. Am J Physiol Cell Physiol [print-electronic]. 2023 Mar 3/1/2023; 324(3): C665-C673-C673. PMID: 36717098, PMCID: PMC9970650, DOI: 10.1152/ajpcell.00211.2022, ISSN: 1522-1563.
Johnson D, Goodman R, Patrinely J, Stone C, Zimmerman E, Donald R, Chang S, Berkowitz S, Finn A, Jahangir E, Scoville E, Reese T, Friedman D, Bastarache J, van der Heijden Y, Wright J, Carter N, Alexander M, Choe J, Chastain C, Zic J, Horst S, Turker I, Agarwal R, Osmundson E, Idrees K, Kieman C, Padmanabhan C, Bailey C, Schlegel C, Chambless L, Gibson M, Osterman T, Wheless L. Assessing the Accuracy and Reliability of AI-Generated Medical Responses: An Evaluation of the Chat-GPT Model. Res Sq. 2023 Feb 2/28/2023; PMID: 36909565, PMCID: PMC10002821, PII: rs.3.rs-2566942, DOI: 10.21203/rs.3.rs-2566942/v1, ISSN: 2693-5015.
Williams Roberson S, Nwosu S, Collar EM, Kiehl AL, Harrison FE, Bastarache J, Wilson JE, Mart MF, Sevransky JE, Ely EW, Lindsell CJ, Jackson JC, . Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial. JAMA Netw Open. 2023 Feb 2/1/2023; 6(2): e230380. PMID: 36853612, PMCID: PMC9975932, PII: 2801791, DOI: 10.1001/jamanetworkopen.2023.0380, ISSN: 2574-3805.
Meegan JE, Kerchberger VE, Fortune NL, McNeil JB, Bastarache JA, Austin ED, Ware LB, Hemnes AR, Brittain EL. Transpulmonary generation of cell-free hemoglobin contributes to vascular dysfunction in pulmonary arterial hypertension via dysregulated clearance mechanisms. Pulm Circ. 2023 Jan; 13(1): e12185. PMID: 36743426, PMCID: PMC9841468, PII: PUL212185, DOI: 10.1002/pul2.12185, ISSN: 2045-8932.
Consoli DC, Spitznagel BD, Owen BM, Kang H, Williams Roberson S, Pandharipande P, Wesley Ely E, Nobis WP, Bastarache JA, Harrison FE. Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis. Brain Behav Immun [print-electronic]. 2023 Jan; 107: 165-78. PMID: 36243287, PMCID: PMC10010333, PII: S0889-1591(22)00408-1, DOI: 10.1016/j.bbi.2022.10.003, ISSN: 1090-2139.
Afzal A, Beavers WN, Skaar EP, Calhoun MC, Richardson KA, Landstreet SR, Cliffel DE, Wright D, Bastarache JA, Ware LB. Ultraviolet light oxidation of fresh hemoglobin eliminates aggregate formation seen in commercially sourced hemoglobin. Blood Cells Mol Dis [print-electronic]. 2023 Jan; 98: 102699. PMID: 36027791, PMCID: PMC10024311, PII: S1079-9796(22)00056-0, DOI: 10.1016/j.bcmd.2022.102699, ISSN: 1096-0961.
Bartlett NW, Bastarache JA, Kuebler WM, Schmidt EP. Call for Papers: "In It for the Long Haul: Understanding the Lasting Impact of COVID-19 on Lung Health and Disease" [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2022 Dec 12/1/2022; 323(6): L683-L684-L684. PMID: 36346147, PMCID: PMC9870585, DOI: 10.1152/ajplung.00352.2022, ISSN: 1522-1504.
Verdonk F, Feyaerts D, Badenes R, Bastarache JA, Bouglé A, Ely W, Gaudilliere B, Howard C, Kotfis K, Lautrette A, Le Dorze M, Mankidy BJ, Matthay MA, Morgan CK, Mazeraud A, Patel BV, Pattnaik R, Reuter J, Schultz MJ, Sharshar T, Shrestha GS, Verdonk C, Ware LB, Pirracchio R, Jabaudon M. Upcoming and urgent challenges in critical care research based on COVID-19 pandemic experience. Anaesth Crit Care Pain Med [print-electronic]. 2022 Oct; 41(5): 101121. PMID: 35781076, PMCID: PMC9245393, PII: S2352-5568(22)00102-3, DOI: 10.1016/j.accpm.2022.101121, ISSN: 2352-5568.
Kerchberger VE, Bastarache JA. Pulmonary Vasculopathy in COVID-19 Acute Respiratory Distress Syndrome: A Step Closer to the Full Picture [editorial]. Am J Respir Crit Care Med. 2022 Oct 10/1/2022; 206(7): 809-10. PMID: 35675564, PMCID: PMC9799262, DOI: 10.1164/rccm.202205-1019ED, ISSN: 1535-4970.
Meegan JE, Komalavilas P, Cheung-Flynn J, Yim TW, Putz ND, Jesse JJ, Smith KD, Sidorova TN, Lee HNR, Tomasek T, Shaver CM, Ware LB, Brophy CM, Bastarache JA. Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis. Physiol Rep. 2022 Jun; 10(11): e15290. PMID: 35668576, PMCID: PMC9170948, DOI: 10.14814/phy2.15290, ISSN: 2051-817X.
Blondonnet R, Simand LA, Vidal P, Borao L, Bourguignon N, Morand D, Bernard L, Roszyk L, Audard J, Godet T, Monsel A, Garnier M, Quesnel C, Bazin JE, Sapin V, Bastarache JA, Ware LB, Hughes CG, Pandharipande PP, Ely EW, Futier E, Pereira B, Constantin JM, Jabaudon M, On Behalf Of The Sesar Collaborative Group. Design and Rationale of the Sevoflurane for Sedation in Acute Respiratory Distress Syndrome (SESAR) Randomized Controlled Trial. J Clin Med. 2022 May 5/16/2022; 11(10): PMID: 35628922, PMCID: PMC9147018, PII: jcm11102796, DOI: 10.3390/jcm11102796, ISSN: 2077-0383.
Bos LDJ, Laffey JG, Ware LB, Heijnen NFL, Sinha P, Patel B, Jabaudon M, Bastarache JA, McAuley DF, Summers C, Calfee CS, Shankar-Hari M. Towards a biological definition of ARDS: are treatable traits the solution?. Intensive Care Med Exp. 2022 Mar 3/11/2022; 10(1): 8. PMID: 35274164, PMCID: PMC8913033, PII: 10.1186/s40635-022-00435-w, DOI: 10.1186/s40635-022-00435-w, ISSN: 2197-425X.
Gandhi VD, Cephus JY, Norlander AE, Chowdhury NU, Zhang J, Ceneviva ZJ, Tannous E, Polosukhin VV, Putz ND, Wickersham N, Singh A, Ware LB, Bastarache JA, Shaver CM, Chu HW, Peebles RS, Newcomb DC. Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. J Clin Invest. 2022 Feb 2/15/2022; 132(4): PMID: 35025767, PMCID: PMC8843736, PII: 153397, DOI: 10.1172/JCI153397, ISSN: 1558-8238.
Bastarache JA, Smith K, Jesse JJ, Putz ND, Meegan JE, Bogart AM, Schaaf K, Ghosh S, Shaver CM, Ware LB. A two-hit model of sepsis plus hyperoxia causes lung permeability and inflammation. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2022 Feb 2/1/2022; 322(2): L273-L282-L282. PMID: 34936510, PMCID: PMC11684993, DOI: 10.1152/ajplung.00227.2021, ISSN: 1522-1504.
Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2022 Jan 1/25/2022; 7(2): PMID: 34874923, PMCID: PMC8855818, PII: 154573, DOI: 10.1172/jci.insight.154573, ISSN: 2379-3708.
Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med [print-electronic]. 2022 Jan; 10(1): 107-20. PMID: 34310901, PMCID: PMC8302189, PII: S2213-2600(21)00157-0, DOI: 10.1016/S2213-2600(21)00157-0, ISSN: 2213-2619.
Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE. Promoting our early career members at AJP-Lung: the Editorial Board Fellowship Program and the Next Generation Physiologist Highlights section at our Journal [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2021 Nov 11/1/2021; 321(5): L844-L846-L846. PMID: 34585617, PMCID: PMC8616620, DOI: 10.1152/ajplung.00389.2021, ISSN: 1522-1504.
McNeil JB, Jackson KE, Wang C, Siew ED, Vincz AJ, Shaver CM, Bastarache JA, Ware LB. Linear Association Between Hypoalbuminemia and Increased Risk of Acute Respiratory Distress Syndrome in Critically Ill Adults. Crit Care Explor. 2021 Sep; 3(9): e0527. PMID: 34549190, PMCID: PMC8443821, DOI: 10.1097/CCE.0000000000000527, ISSN: 2639-8028.
Meegan JE, Bastarache JA, Ware LB. Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2021 Aug 8/1/2021; 321(2): L429-L439-L439. PMID: 34009034, PMCID: PMC8526348, DOI: 10.1152/ajplung.00018.2021, ISSN: 1522-1504.
Reynolds RA, Amin SN, Jonathan SV, Tang AR, Lan M, Wang C, Bastarache JA, Ware LB, Thompson RC. Hyperoxemia and Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage. Neurocrit Care [print-electronic]. 2021 Aug; 35(1): 30-8. PMID: 33150573, PMCID: PMC8093321, PII: 10.1007/s12028-020-01136-6, DOI: 10.1007/s12028-020-01136-6, ISSN: 1556-0961.
Kerchberger VE, Brown RM, Semler MW, Zhao Z, Koyama T, Janz DR, Bastarache JA, Ware LB. Impact of Clinician Recognition of Acute Respiratory Distress Syndrome on Evidenced-Based Interventions in the Medical ICU. Crit Care Explor. 2021 Jul; 3(7): e0457. PMID: 34250497, PMCID: PMC8263322, DOI: 10.1097/CCE.0000000000000457, ISSN: 2639-8028.
Bos LDJ, Bastarache JA. Cleaving the Acute Respiratory Distress Syndrome into Treatable Traits: A Role for Caspase 1? [editorial]. Am J Respir Crit Care Med. 2021 Jul 7/1/2021; 204(1): 6-7. PMID: 33826872, PMCID: PMC8437118, DOI: 10.1164/rccm.202102-0479ED, ISSN: 1535-4970.
Tomasek T, Ware LB, Bastarache JA, Meegan JE. Cell-free hemoglobin-mediated human lung microvascular endothelial barrier dysfunction is not mediated by cell death. Biochem Biophys Res Commun [print-electronic]. 2021 Jun 6/4/2021; 556: 199-206. PMID: 33848934, PMCID: PMC8483287, PII: S0006-291X(21)00574-X, DOI: 10.1016/j.bbrc.2021.03.161, ISSN: 1090-2104.
Jabaudon M, Pereira B, Laroche E, Roszyk L, Blondonnet R, Audard J, Godet T, Futier E, Bazin JE, Sapin V, Bastarache JA, Ware LB, Constantin JM, On Behalf Of The Live Study Group And The Azurea Network. Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome. J Clin Med. 2021 May 5/12/2021; 10(10): PMID: 34066048, PMCID: PMC8150905, PII: jcm10102076, DOI: 10.3390/jcm10102076, ISSN: 2077-0383.
Bastarache JA, McNeil JB, Plosa EJ, Sucre JS, Kerchberger VE, Habegger LE, Weddle E, Sullivan B, Meegan JE, Wickersham NE, Shaver CM, Ware LB. Standardization of methods for sampling the distal airspace in mechanically ventilated patients using heat moisture exchange filter fluid. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2021 May 5/1/2021; 320(5): L785-L790-L790. PMID: 33655765, PMCID: PMC8174823, DOI: 10.1152/ajplung.00595.2020, ISSN: 1522-1504.
Yu WK, McNeil JB, Wickersham NE, Shaver CM, Bastarache JA, Ware LB. Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure. Crit Care. 2021 Feb 2/4/2021; 25(1): 48. PMID: 33541396, PMCID: PMC7859898, PII: 10.1186/s13054-021-03474-z, DOI: 10.1186/s13054-021-03474-z, ISSN: 1466-609X.
Chen HH, Shaw DM, Petty LE, Graff M, Bohlender RJ, Polikowsky HG, Zhong X, Kim D, Buchanan VL, Preuss MH, Shuey MM, Loos RJF, Huff CD, Cox NJ, Bastarache JA, Bastarache L, North KE, Below JE. Host genetic effects in pneumonia. Am J Hum Genet [print-electronic]. 2021 Jan 1/7/2021; 108(1): 194-201. PMID: 33357513, PMCID: PMC7820802, PII: S0002-9297(20)30446-8, DOI: 10.1016/j.ajhg.2020.12.010, ISSN: 1537-6605.
Summers ME, Richmond BW, Kropski JA, Majka SA, Bastarache JA, Hatzopoulos AK, Bylund J, Ghosh M, Petrache I, Foronjy RF, Geraghty P, Majka SM. Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function. Am J Physiol Cell Physiol [print-electronic]. 2021 Jan 1/1/2021; 320(1): C119-C131-C131. PMID: 33085496, PMCID: PMC7846975, DOI: 10.1152/ajpcell.00277.2020, ISSN: 1522-1563.
Jabaudon M, Audard J, Pereira B, Jaber S, Lefrant JY, Blondonnet R, Godet T, Futier E, Lambert C, Bazin JE, Bastarache JA, Constantin JM, Ware LB, . Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS. Chest [print-electronic]. 2020 Dec; 158(6): 2394-403. PMID: 32659235, PMCID: PMC7768934, PII: S0012-3692(20)31874-2, DOI: 10.1016/j.chest.2020.06.070, ISSN: 1931-3543.
Shaver CM, Landstreet SR, Pugazenthi S, Scott F, Putz N, Ware LB, Bastarache JA. The NLRP3 inflammasome in macrophages is stimulated by cell-free hemoglobin. Physiol Rep. 2020 Nov; 8(21): e14589. PMID: 33128438, PMCID: PMC7601531, DOI: 10.14814/phy2.14589, ISSN: 2051-817X.
Bastarache JA. The future of sepsis research: time to think differently? [editorial]. Am J Physiol Lung Cell Mol Physiol [print-electronic]. 2020 Sep 9/1/2020; 319(3): L523-L526-L526. PMID: 32755382, PMCID: PMC7518062, DOI: 10.1152/ajplung.00368.2020, ISSN: 1522-1504.
Summers ME, Richmond BW, Menon S, Sheridan RM, Kropski JA, Majka SA, Taketo MM, Bastarache JA, West JD, De Langhe S, Geraghty P, Klemm DJ, Chu HW, Friedman RS, Tao YK, Foronjy RF, Majka SM. Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling. FASEB J [print-electronic]. 2020 Aug; 34(8): 10267-85. PMID: 32533805, PMCID: PMC7496763, DOI: 10.1096/fj.202000629R, ISSN: 1530-6860.
Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, Artigas A, Rocco PRM, Matthay MA, McAuley DF, Constantin JM, Jabaudon M, . Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis. Respir Res. 2020 Apr 4/7/2020; 21(1): 81. PMID: 32264897, PMCID: PMC7137453, PII: 10.1186/s12931-020-01337-9, DOI: 10.1186/s12931-020-01337-9, ISSN: 1465-993X.
Jabaudon M, Bastarache JA, Ware LB. Eyes wide open on bronchial aeration in acute respiratory distress syndrome [editorial]. Anaesth Crit Care Pain Med [print-electronic]. 2020 Apr; 39(2): 191-2. PMID: 32145431, PII: S2352-5568(20)30035-7, DOI: 10.1016/j.accpm.2020.03.003, ISSN: 2352-5568.
Willen SM, McNeil JB, Rodeghier M, Kerchberger VE, Shaver CM, Bastarache JA, Steinberg MH, DeBaun MR, Ware LB. Haptoglobin genotype predicts severe acute vaso-occlusive pain episodes in children with sickle cell anemia [letter]. Am J Hematol [print-electronic]. 2020 Apr; 95(4): E92-E95-E95. PMID: 31919880, PMCID: PMC7343605, DOI: 10.1002/ajh.25728, ISSN: 1096-8652.
Consoli DC, Jesse JJ, Klimo KR, Tienda AA, Putz ND, Bastarache JA, Harrison FE. A Cecal Slurry Mouse Model of Sepsis Leads to Acute Consumption of Vitamin C in the Brain. Nutrients. 2020 Mar 3/26/2020; 12(4): PMID: 32224930, PMCID: PMC7231213, PII: nu12040911, DOI: 10.3390/nu12040911, ISSN: 2072-6643.
Meegan JE, Shaver CM, Putz ND, Jesse JJ, Landstreet SR, Lee HNR, Sidorova TN, McNeil JB, Wynn JL, Cheung-Flynn J, Komalavilas P, Brophy CM, Ware LB, Bastarache JA. Cell-free hemoglobin increases inflammation, lung apoptosis, and microvascular permeability in murine polymicrobial sepsis. PLoS One. 2020; 15(2): e0228727. PMID: 32012200, PMCID: PMC6996826, PII: PONE-D-19-12903, DOI: 10.1371/journal.pone.0228727, ISSN: 1932-6203.
Kerchberger VE, Huang Y, Koyama T, Shoemaker MB, Darbar D, Bastarache JA, Ware LB, Shaver CM. Clinical and Genetic Contributors to New-Onset Atrial Fibrillation in Critically Ill Adults. Crit Care Med. 2020 Jan; 48(1): 22-30. PMID: 31599812, PMCID: PMC6910934, DOI: 10.1097/CCM.0000000000004034, ISSN: 1530-0293.
Kerchberger VE, Bastarache JA, Shaver CM, Nagata H, McNeil JB, Landstreet SR, Putz ND, Yu WK, Jesse J, Wickersham NE, Sidorova TN, Janz DR, Parikh CR, Siew ED, Ware LB. Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis. JCI Insight. 2019 Nov 11/1/2019; 4(21): PMID: 31573976, PMCID: PMC6948757, PII: 131206, DOI: 10.1172/jci.insight.131206, ISSN: 2379-3708.
Shaver CM, Paul MG, Putz ND, Landstreet SR, Kuck JL, Scarfe L, Skrypnyk N, Yang H, Harrison FE, de Caestecker MP, Bastarache JA, Ware LB. Cell-free hemoglobin augments acute kidney injury during experimental sepsis. Am J Physiol Renal Physiol [print-electronic]. 2019 Oct 10/1/2019; 317(4): F922-F929-F929. PMID: 31364379, PMCID: PMC6843044, DOI: 10.1152/ajprenal.00375.2018, ISSN: 1522-1466.
Bastarache L, Bastarache JA, Denny JC. Case 40-2018: A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis [letter]. N Engl J Med. 2019 Apr 4/4/2019; 380(14): 1382-3. PMID: 30943357, PMCID: PMC10507791, PII: 10.1056/NEJMc1901268#sa1, DOI: 10.1056/NEJMc1901268, ISSN: 1533-4406.
Yu WK, McNeil JB, Wickersham NE, Shaver CM, Bastarache JA, Ware LB. Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury. Crit Care. 2019 Jan 1/18/2019; 23(1): 18. PMID: 30658667, PMCID: PMC6339439, PII: 10.1186/s13054-019-2315-y, DOI: 10.1186/s13054-019-2315-y, ISSN: 1466-609X.
McPeake J, Hirshberg EL, Christie LM, Drumright K, Haines K, Hough CL, Meyer J, Wade D, Andrews A, Bakhru R, Bates S, Barwise JA, Bastarache J, Beesley SJ, Boehm LM, Brown S, Clay AS, Firshman P, Greenberg S, Harris W, Hill C, Hodgson C, Holdsworth C, Hope AA, Hopkins RO, Howell DCJ, Janssen A, Jackson JC, Johnson A, Kross EK, Lamas D, MacLeod-Smith B, Mandel R, Marshall J, Mikkelsen ME, Nackino M, Quasim T, Sevin CM, Slack A, Spurr R, Still M, Thompson C, Weinhouse G, Wilcox ME, Iwashyna TJ. Models of Peer Support to Remediate Post-Intensive Care Syndrome: A Report Developed by the Society of Critical Care Medicine Thrive International Peer Support Collaborative. Crit Care Med. 2019 Jan; 47(1): e21-e27-e27. PMID: 30422863, PMCID: PMC6719778, DOI: 10.1097/CCM.0000000000003497, ISSN: 1530-0293.
Bloodworth NC, Clark CR, West JD, Snider JC, Gaskill C, Shay S, Scott C, Bastarache J, Gladson S, Moore C, D'Amico R, Brittain EL, Tanjore H, Blackwell TS, Majka SM, Merryman WD. Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism. Circ Res. 2018 Dec 12/7/2018; 123(12): e51-e64-e64. PMID: 30566041, PMCID: PMC6309812, DOI: 10.1161/CIRCRESAHA.118.313397, ISSN: 1524-4571.
Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB. Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS. Thorax [print-electronic]. 2018 Sep; 73(9): 840-6. PMID: 29903755, PMCID: PMC6410734, PII: thoraxjnl-2017-211280, DOI: 10.1136/thoraxjnl-2017-211280, ISSN: 1468-3296.
Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 Sep; 59(3): 363-74. PMID: 29584451, PMCID: PMC6189644, DOI: 10.1165/rcmb.2017-0428OC, ISSN: 1535-4989.
McNeil JB, Shaver CM, Kerchberger VE, Russell DW, Grove BS, Warren MA, Wickersham NE, Ware LB, McDonald WH, Bastarache JA. Novel Method for Noninvasive Sampling of the Distal Airspace in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 Apr 4/15/2018; 197(8): 1027-35. PMID: 29253353, PMCID: PMC5909163, DOI: 10.1164/rccm.201707-1474OC, ISSN: 1535-4970.
Putz ND, Shaver CM, Dufu K, Li CM, Xu Q, Hutchaleelaha A, Lehrer-Graiwer J, Majka SM, Ware LB, Bastarache JA. GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival in murine hypoxic acute lung injury. J Appl Physiol (1985) [print-electronic]. 2018 Apr 4/1/2018; 124(4): 899-905. PMID: 29357510, PMCID: PMC7002864, DOI: 10.1152/japplphysiol.00079.2017, ISSN: 1522-1601.
Shaver CM, Wickersham N, McNeil JB, Nagata H, Miller A, Landstreet SR, Kuck JL, Diamond JM, Lederer DJ, Kawut SM, Palmer SM, Wille KM, Weinacker A, Lama VN, Crespo MM, Orens JB, Shah PD, Hage CA, Cantu E, Porteous MK, Dhillon G, McDyer J, Bastarache JA, Christie JD, Ware LB, . Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury. JCI Insight. 2018 Jan 1/25/2018; 3(2): PMID: 29367464, PMCID: PMC5821179, PII: 98546, DOI: 10.1172/jci.insight.98546, ISSN: 2379-3708.
Kuck JL, Bastarache JA, Shaver CM, Fessel JP, Dikalov SI, May JM, Ware LB. Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. Biochem Biophys Res Commun [print-electronic]. 2018 Jan 1/1/2018; 495(1): 433-7. PMID: 29129689, PMCID: PMC5736437, PII: S0006-291X(17)32236-2, DOI: 10.1016/j.bbrc.2017.11.058, ISSN: 1090-2104.
DesPrez K, McNeil JB, Wang C, Bastarache JA, Shaver CM, Ware LB. Oxygenation Saturation Index Predicts Clinical Outcomes in ARDS. Chest [print-electronic]. 2017 Dec; 152(6): 1151-8. PMID: 28823812, PMCID: PMC5812755, PII: S0012-3692(17)31395-8, DOI: 10.1016/j.chest.2017.08.002, ISSN: 1931-3543.
Casey JD, Semler MW, Bastarache JA. Aspirin for Sepsis Prophylaxis: An Ounce of Prevention? [editorial]. Crit Care Med. 2017 Nov; 45(11): 1959-60. PMID: 29028704, PMCID: PMC5658041, PII: 00003246-201711000-00028, DOI: 10.1097/CCM.0000000000002669, ISSN: 1530-0293.
Murphy LS, Wickersham N, McNeil JB, Shaver CM, May AK, Bastarache JA, Ware LB. Endothelial glycocalyx degradation is more severe in patients with non-pulmonary sepsis compared to pulmonary sepsis and associates with risk of ARDS and other organ dysfunction. Ann Intensive Care. 2017 Oct 10/6/2017; 7(1): 102. PMID: 28986821, PMCID: PMC5630541, PII: 10.1186/s13613-017-0325-y, DOI: 10.1186/s13613-017-0325-y, ISSN: 2110-5820.
Zheng NS, Bastarache LA, Bastarache JA, Lu Y, Ware LB, Shu XO, Denny JC, Long J. A common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women. J Hum Genet [print-electronic]. 2017 Oct; 62(10): 911-4. PMID: 28659611, PMCID: PMC5824713, PII: jhg201766, DOI: 10.1038/jhg.2017.66, ISSN: 1435-232X.
Shaver CM, Wickersham N, McNeil JB, Nagata H, Sills G, Kuck JL, Janz DR, Bastarache JA, Ware LB. Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. Ann Am Thorac Soc. 2017 Sep; 14(Supplement_3): S251-S252-S252. PMID: 28945473, PMCID: PMC5711346, DOI: 10.1513/AnnalsATS.201609-693MG, ISSN: 2325-6621.
Shaver CM, Woods J, Clune JK, Grove BS, Wickersham NE, McNeil JB, Shemancik G, Ware LB, Bastarache JA. Circulating microparticle levels are reduced in patients with ARDS. Crit Care. 2017 May 5/25/2017; 21(1): 120. PMID: 28545548, PMCID: PMC5445431, PII: 10.1186/s13054-017-1700-7, DOI: 10.1186/s13054-017-1700-7, ISSN: 1466-609X.
Luo L, Shaver CM, Zhao Z, Koyama T, Calfee CS, Bastarache JA, Ware LB. Clinical Predictors of Hospital Mortality Differ Between Direct and Indirect ARDS. Chest [print-electronic]. 2017 Apr; 151(4): 755-63. PMID: 27663180, PMCID: PMC5472517, PII: S0012-3692(16)59167-3, DOI: 10.1016/j.chest.2016.09.004, ISSN: 1931-3543.
Tatsumi K, Antoniak S, Subramaniam S, Gondouin B, Neidich SD, Beck MA, Mickelson J, Monroe DM, Bastarache JA, Mackman N. Anticoagulation increases alveolar hemorrhage in mice infected with influenza A. Physiol Rep. 2016 Dec; 4(24): PMID: 28003564, PMCID: PMC5210384, PII: 4/24/e13071, DOI: 10.14814/phy2.13071, ISSN: 2051-817X.
Rondina MT, Tatsumi K, Bastarache JA, Mackman N. Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection. Crit. Care Med. 2016 Jul; 44(7): e574-8. PMID: 26751613, PMCID: PMC4911267, DOI: 10.1097/CCM.0000000000001584, ISSN: 1530-0293.
Antoniak S, Tatsumi K, Hisada Y, Milner JJ, Neidich SD, Shaver CM, Pawlinski R, Beck MA, Bastarache JA, Mackman N. Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice. J. Thromb. Haemost [print-electronic]. 2016 Jun; 14(6): 1238-48. PMID: 26947929, DOI: 10.1111/jth.13307, ISSN: 1538-7836.
Bastarache JA, Seeley EJ. Sepsis [editorial]. Clin. Chest Med. 2016 Jun; 37(2): xv-xvi. PMID: 27229652, PII: S0272-5231(16)30025-9, DOI: 10.1016/j.ccm.2016.04.001, ISSN: 1557-8216.
Shaver CM, Upchurch CP, Janz DR, Grove BS, Putz ND, Wickersham NE, Dikalov SI, Ware LB, Bastarache JA. Cell-free hemoglobin: a novel mediator of acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2016 Mar 3/15/2016; 310(6): L532-41. PMID: 26773065, PMCID: PMC4796260, PII: ajplung.00155.2015, DOI: 10.1152/ajplung.00155.2015, ISSN: 1522-1504.
Shaver CM, Grove BS, Clune JK, Mackman N, Ware LB, Bastarache JA. Myeloid tissue factor does not modulate lung inflammation or permeability during experimental acute lung injury. Sci Rep. 2016; 6: 22249. PMID: 26924425, PMCID: PMC4770302, PII: srep22249, DOI: 10.1038/srep22249, ISSN: 2045-2322.
Chen W, Janz DR, Shaver CM, Bernard GR, Bastarache JA, Ware LB. Clinical Characteristics and Outcomes Are Similar in ARDS Diagnosed by Oxygen Saturation/Fio2 Ratio Compared With Pao2/Fio2 Ratio. Chest. 2015 Dec; 148(6): 1477-83. PMID: 26271028, PMCID: PMC4665739, PII: S0012-3692(15)50112-8, DOI: 10.1378/chest.15-0169, ISSN: 1931-3543.
Shaver CM, Grove BS, Putz ND, Clune JK, Lawson WE, Carnahan RH, Mackman N, Ware LB, Bastarache JA. Regulation of alveolar procoagulant activity and permeability in direct acute lung injury by lung epithelial tissue factor. Am. J. Respir. Cell Mol. Biol. 2015 Nov; 53(5): 719-27. PMID: 25884207, PMCID: PMC4742948, DOI: 10.1165/rcmb.2014-0179OC, ISSN: 1535-4989.
Shaver CM, Chen W, Janz DR, May AK, Darbar D, Bernard GR, Bastarache JA, Ware LB. Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit. Care Med. 2015 Oct; 43(10): 2104-11. PMID: 26154932, PMCID: PMC4725582, DOI: 10.1097/CCM.0000000000001166, ISSN: 1530-0293.
Chen W, Janz DR, Bastarache JA, May AK, O'Neal HR, Bernard GR, Ware LB. Prehospital aspirin use is associated with reduced risk of acute respiratory distress syndrome in critically ill patients: a propensity-adjusted analysis. Crit. Care Med. 2015 Apr; 43(4): 801-7. PMID: 25559436, PMCID: PMC4359645, DOI: 10.1097/CCM.0000000000000789, ISSN: 1530-0293.
Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ, Ware LB, . Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. Crit. Care Med. 2015 Mar; 43(3): 534-41. PMID: 25474535, PMCID: PMC4336619, DOI: 10.1097/CCM.0000000000000718, ISSN: 1530-0293.
Bastarache JA, Wynn JL, Ware LB. Fanning the Fire: Can Methemoglobin Enhance Neutrophil Activation?. EBioMedicine. 2015 Mar; 2(3): 184-5. PMID: 26137557, PMCID: PMC4485487, PII: S2352-3964(15)00043-2, DOI: 10.1016/j.ebiom.2015.01.019, ISSN: 2352-3964.
Ware LB, Bastarache JA, Calfee CS. ARDS: new mechanistic insights, new therapeutic directions [editorial]. Clin. Chest Med [print-electronic]. 2014 Dec; 35(4): xv-xvi. PMID: 25453428, PII: S0272-5231(14)00086-0, DOI: 10.1016/j.ccm.2014.09.001, ISSN: 1557-8216.
Shaver CM, Bastarache JA. Clinical and biological heterogeneity in acute respiratory distress syndrome: direct versus indirect lung injury. Clin. Chest Med [print-electronic]. 2014 Dec; 35(4): 639-53. PMID: 25453415, PMCID: PMC4254695, PII: S0272-5231(14)00073-2, DOI: 10.1016/j.ccm.2014.08.004, ISSN: 1557-8216.
Brittain EL, Janz DR, Austin ED, Bastarache JA, Wheeler LA, Ware LB, Hemnes AR. Elevation of plasma cell-free hemoglobin in pulmonary arterial hypertension. Chest. 2014 Dec; 146(6): 1478-85. PMID: 24945582, PMCID: PMC4251612, PII: S0012-3692(15)51517-1, DOI: 10.1378/chest.14-0809, ISSN: 1931-3543.
Bastarache JA, Koyama T, Wickersham NE, Ware LB. Validation of a multiplex electrochemiluminescent immunoassay platform in human and mouse samples. J. Immunol. Methods [print-electronic]. 2014 Jun; 408: 13-23. PMID: 24768796, PMCID: PMC4120713, PII: S0022-1759(14)00123-9, DOI: 10.1016/j.jim.2014.04.006, ISSN: 1872-7905.
Bastarache JA, Roberts LJ, Ware LB. Thinking outside the cell: how cell-free hemoglobin can potentiate acute lung injury [editorial]. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2014 Feb; 306(3): L231-2. PMID: 24337924, PMCID: PMC3920200, PII: ajplung.00355.2013, DOI: 10.1152/ajplung.00355.2013, ISSN: 1522-1504.
Richmond BW, Worrell JA, Bastarache JA, Gervich DH, Slattery WR, Loyd JE. Histoplasmomas of uncommon size. Chest. 2013 Jun; 143(6): 1795-8. PMID: 23732591, PII: S0012-3692(13)60414-6, DOI: 10.1378/chest.12-2071, ISSN: 1931-3543.
Sebag SC, Bastarache JA, Ware LB. Mechanical stretch inhibits lipopolysaccharide-induced keratinocyte-derived chemokine and tissue factor expression while increasing procoagulant activity in murine lung epithelial cells. J. Biol. Chem [print-electronic]. 2013 Mar 3/15/2013; 288(11): 7875-84. PMID: 23362270, PMCID: PMC3597825, PII: M112.403220, DOI: 10.1074/jbc.M112.403220, ISSN: 1083-351X.
Janz DR, Bastarache JA, Peterson JF, Sills G, Wickersham N, May AK, Roberts LJ, Ware LB. Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. Crit. Care Med. 2013 Mar; 41(3): 784-90. PMID: 23314583, PMCID: PMC3578977, DOI: 10.1097/CCM.0b013e3182741a54, ISSN: 1530-0293.
Janz DR, Zhao Z, Koyama T, May AK, Bernard GR, Bastarache JA, Young PP, Ware LB. Longer storage duration of red blood cells is associated with an increased risk of acute lung injury in patients with sepsis. Ann Intensive Care. 2013; 3(1): 33. PMID: 24059842, PMCID: PMC3848804, PII: 2110-5820-3-33, DOI: 10.1186/2110-5820-3-33, ISSN: 2110-5820.
Bastarache JA, Sebag SC, Clune JK, Grove BS, Lawson WE, Janz DR, Roberts LJ, Dworski R, Mackman N, Ware LB. Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress. Thorax [print-electronic]. 2012 Dec; 67(12): 1032-9. PMID: 23033361, PMCID: PMC3652432, PII: thoraxjnl-2012-201781, DOI: 10.1136/thoraxjnl-2012-201781, ISSN: 1468-3296.
Bastarache JA, Ware LB, Girard TD, Wheeler AP, Rice TW. Markers of inflammation and coagulation may be modulated by enteral feeding strategy. JPEN J Parenter Enteral Nutr [print-electronic]. 2012 Nov; 36(6): 732-40. PMID: 22318965, PMCID: PMC3726194, PII: 0148607111433054, DOI: 10.1177/0148607111433054, ISSN: 0148-6071.
Zeyed YF, Bastarache JA, Matthay MA, Ware LB. The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2012 Sep 9/15/2012; 303(6): L550-5. PMID: 22821995, PMCID: PMC3468480, PII: ajplung.00190.2012, DOI: 10.1152/ajplung.00190.2012, ISSN: 1522-1504.
Bastarache JA, Diamond JM, Kawut SM, Lederer DJ, Ware LB, Christie JD. Postoperative estradiol levels associate with development of primary graft dysfunction in lung transplantation patients. Gend Med [print-electronic]. 2012 Jun; 9(3): 154-65. PMID: 22361838, PMCID: PMC3374892, PII: S1550-8579(12)00049-6, DOI: 10.1016/j.genm.2012.01.009, ISSN: 1878-7398.
Bastarache JA, Sebag SC, Grove BS, Ware LB. Interferon-¿ and tumor necrosis factor-a act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp. Lung Res. 2011 Oct; 37(8): 509-17. PMID: 21913843, PMCID: PMC3652424, DOI: 10.3109/01902148.2011.605512, ISSN: 1521-0499.
Sebag SC, Bastarache JA, Ware LB. Therapeutic modulation of coagulation and fibrinolysis in acute lung injury and the acute respiratory distress syndrome. Curr Pharm Biotechnol. 2011 Sep; 12(9): 1481-96. PMID: 21401517, PMCID: PMC3893117, PII: BSP/CPB/E-Pub/000104-12-9, ISSN: 1873-4316.
Bastarache JA, Ong T, Matthay MA, Ware LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Crit Care [print-electronic]. 2011 Jun; 26(3): 249-56. PMID: 20688464, PMCID: PMC2982881, PII: S0883-9441(10)00168-1, DOI: 10.1016/j.jcrc.2010.06.005, ISSN: 1557-8615.
Bastarache JA, Koyama T, Wickersham NE, Mitchell DB, Mernaugh RL, Ware LB. Accuracy and reproducibility of a multiplex immunoassay platform: a validation study. J. Immunol. Methods [print-electronic]. 2011 Mar 3/31/2011; 367(1-2): 33-9. PMID: 21277854, PMCID: PMC3108329, PII: S0022-1759(11)00008-1, DOI: 10.1016/j.jim.2011.01.005, ISSN: 1872-7905.
Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA. Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio. Eur. Respir. J [print-electronic]. 2010 Feb; 35(2): 331-7. PMID: 19741024, PMCID: PMC2819058, PII: 09031936.00098709, DOI: 10.1183/09031936.00098709, ISSN: 1399-3003.
Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB. Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2009 Dec; 297(6): L1035-41. PMID: 19700643, PMCID: PMC2793184, PII: 00214.2009, DOI: 10.1152/ajplung.00214.2009, ISSN: 1522-1504.
Bastarache JA, Blackwell TS. Development of animal models for the acute respiratory distress syndrome. Dis Model Mech. 2009 May; 2(5-6): 218-23. PMID: 19407329, PMCID: PMC2675821, PII: 2/5-6/218, DOI: 10.1242/dmm.001677, ISSN: 1754-8411.
Bastarache JA, Wang L, Wang Z, Albertine KH, Matthay MA, Ware LB. Intra-alveolar tissue factor pathway inhibitor is not sufficient to block tissue factor procoagulant activity. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2008 May; 294(5): L874-81. PMID: 18310227, PMCID: PMC2764534, PII: 00372.2007, DOI: 10.1152/ajplung.00372.2007, ISSN: 1040-0605.
Wang L, Bastarache JA, Ware LB. The coagulation cascade in sepsis. Curr. Pharm. Des. 2008; 14(19): 1860-9. PMID: 18691097, ISSN: 1873-4286.
Worrell JA, Donnelly EF, Martin JB, Bastarache JA, Loyd JE. Computed tomography and the idiopathic form of proliferative fibrosing mediastinitis. J Thorac Imaging. 2007 Aug; 22(3): 235-40. PMID: 17721332, PII: 00005382-200708000-00004, DOI: 10.1097/01.rti.0000213589.29472.18, ISSN: 0883-5993.
Bastarache JA, Wang L, Geiser T, Wang Z, Albertine KH, Matthay MA, Ware LB. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax [print-electronic]. 2007 Jul; 62(7): 608-16. PMID: 17356058, PMCID: PMC2117249, PII: thx.2006.063305, DOI: 10.1136/thx.2006.063305, ISSN: 0040-6376.
Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am. J. Respir. Cell Mol. Biol [print-electronic]. 2007 Apr; 36(4): 497-503. PMID: 17099142, PMCID: PMC1899324, PII: 2005-0425OC, DOI: 10.1165/rcmb.2005-0425OC, ISSN: 1044-1549.
Bastarache JA, Ware LB, Bernard GR. The role of the coagulation cascade in the continuum of sepsis and acute lung injury and acute respiratory distress syndrome. Semin Respir Crit Care Med. 2006 Aug; 27(4): 365-76. PMID: 16909370, DOI: 10.1055/s-2006-948290, ISSN: 1069-3424.
Ware LB, Bastarache JA, Wang L. Coagulation and fibrinolysis in human acute lung injury--new therapeutic targets?. Keio J Med. 2005 Sep; 54(3): 142-9. PMID: 16237276, ISSN: 0022-9717.
Available Postdoctoral Position Details
Posted: 8/14/2017
Description of Position
A postdoctoral position is immediately available in the laboratories of Dr. Lorraine Ware, Professor of Medicine and Pathology, Microbioloby and Immunology and Dr. Julie Bastarache, Department of Medicine at Vanderbilt University School of Medicine. Our translational research group studies pathogenic mechanisms of sepsis and acute lung injury with a specific focus on mechanisms of lung epithelial and endothelial injury. A major focus is on understanding the cellular and molecular mechanisms of cell-free hemoglobin-mediated lung epithelial and microvascular endothelial permeability. This postdoctoral fellowship will afford the fellow the opportunity to drive this project forward using a multitude of tools and models available in our group including primary and immortalized cell culture, multiple genetically modifed mouse lines, mouse models of acute lung injury and sepsis as well as the ex vivo perfused human lung.
Qualifications for the Position
Candidates must have an MD and/or PhD in a related medical or biological sciences field. Successful candidates should be self-starters and highly motivated to thrive in a rich research environment. Expertise with cell culture and mouse studies is required. Specific expertise in mitochondrial biology, apoptosis, and/or redox biology would be helpful but is not required. The successful candidate should have a demonstrated ability to work both independently and collaboratively, possess strong oral and written communication skills and have a strong foundation in bench science. Responsibilities include designing and implementing experiments, data collection and review, abstract and manuscript preparation and local and national scientific presentations. A successful fellow will leave the program with a broad knowledge of acute lung injury and sepsis, a robust scientific skillset, expertise in a wide range of laboratory techniques and an opportunity for presentation and publication.
Questions about the position can be directed to Lorraine.ware@vanderbilt.edu or Julie.bastarache@vanderbilt.edu.