Lori A. Coburn, M.D.

Assistant Professor

lori.coburn@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine
Education
M.D., Harvard University, Cambridge, MassachusettsB.S., Lyon College, Batesville, Arkansas
Office Address
Gastroenterology Division - 1030-C Medical Research Building IV
Nashville, TN 37232-0252
Publications
Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS, Koyama T, Zhao Z, Adams DW, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics [print-electronic]. 2018 Jan; 14(1): PMID: 29681789, PMCID: PMC5907923, DOI: 10.1007/s11306-017-1311-y, ISSN: 1573-3882.

McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight [print-electronic]. 2017 Aug 8/17/2017; 2(16): PMID: 28814670, PMCID: PMC5621889, PII: 78210, DOI: 10.1172/jci.insight.78210, ISSN: 2379-3708.

Hardbower DM, Coburn LA, Asim M, Singh K, Sierra JC, Barry DP, Gobert AP, Piazuelo MB, Washington MK, Wilson KT. EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis. Oncogene [print-electronic]. 2017 Jul 7/6/2017; 36(27): 3807-19. PMID: 28263971, PMCID: PMC5501754, PII: onc201723, DOI: 10.1038/onc.2017.23, ISSN: 1476-5594.

Singh K, Al-Greene NT, Verriere TG, Coburn LA, Asim M, Barry DP, Allaman MM, Hardbower DM, Delgado AG, Piazuelo MB, Vallance BA, Gobert AP, Wilson KT. The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. PLoS Pathog. 2016 Oct; 12(10): e1005984. PMID: 27783672, PMCID: PMC5081186, PII: PPATHOGENS-D-16-01126, DOI: 10.1371/journal.ppat.1005984, ISSN: 1553-7374.

Wroblewski LE, Peek RM, Coburn LA. The Role of the Microbiome in Gastrointestinal Cancer. Gastroenterol. Clin. North Am. 2016 Sep; 45(3): 543-56. PMID: 27546848, PMCID: PMC4994977, PII: S0889-8553(16)30042-5, DOI: 10.1016/j.gtc.2016.04.010, ISSN: 1558-1942.

Coburn LA, Horst SN, Allaman MM, Brown CT, Williams CS, Hodges ME, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT. L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis. Inflamm. Bowel Dis. 2016 Aug; 22(8): 1847-58. PMID: 27104830, PMCID: PMC4956554, DOI: 10.1097/MIB.0000000000000790, ISSN: 1536-4844.

Wiese DM, Horst SN, Brown CT, Allaman MM, Hodges ME, Slaughter JC, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Serum Fatty Acids Are Correlated with Inflammatory Cytokines in Ulcerative Colitis. PLoS ONE. 2016; 11(5): e0156387. PMID: 27227540, PMCID: PMC4882051, PII: PONE-D-15-55618, DOI: 10.1371/journal.pone.0156387, ISSN: 1932-6203.

Waddell A, Vallance JE, Moore PD, Hummel AT, Wu D, Shanmukhappa SK, Fei L, Washington MK, Minar P, Coburn LA, Nakae S, Wilson KT, Denson LA, Hogan SP, Rosen MJ. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function. Inflamm. Bowel Dis. 2015 Dec; 21(12): 2737-46. PMID: 26313694, PMCID: PMC4654638, DOI: 10.1097/MIB.0000000000000532, ISSN: 1536-4844.

Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW. MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut [print-electronic]. 2013 Oct; 62(10): 1446-55. PMID: 22833394, PMCID: PMC3663894, PII: gutjnl-2011-301439, DOI: 10.1136/gutjnl-2011-301439, ISSN: 1468-3288.

Singh K, Coburn LA, Barry DP, Asim M, Scull BP, Allaman MM, Lewis ND, Washington MK, Rosen MJ, Williams CS, Chaturvedi R, Wilson KT. Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2013 Aug 8/1/2013; 305(3): G225-40. PMID: 23703655, PMCID: PMC3742860, PII: ajpgi.00091.2013, DOI: 10.1152/ajpgi.00091.2013, ISSN: 1522-1547.

Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J. Immunol [print-electronic]. 2013 Feb 2/15/2013; 190(4): 1849-58. PMID: 23303670, PMCID: PMC3563924, PII: jimmunol.1201373, DOI: 10.4049/jimmunol.1201373, ISSN: 1550-6606.

Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res [print-electronic]. 2013 Feb 2/1/2013; 73(3): 1245-55. PMID: 23221387, PMCID: PMC3563732, PII: 0008-5472.CAN-12-3150, DOI: 10.1158/0008-5472.CAN-12-3150, ISSN: 1538-7445.

Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KT. High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS ONE. 2013; 8(12): e82300. PMID: 24367513, PMCID: PMC3867379, PII: PONE-D-13-38373, DOI: 10.1371/journal.pone.0082300, ISSN: 1932-6203.

Singh K, Coburn LA, Barry DP, Boucher JL, Chaturvedi R, Wilson KT. L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2012 May 5/1/2012; 302(9): G1061-73. PMID: 22361732, PMCID: PMC3362080, PII: ajpgi.00544.2011, DOI: 10.1152/ajpgi.00544.2011, ISSN: 1522-1547.

Chaturvedi R, de Sablet T, Coburn LA, Gobert AP, Wilson KT. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino Acids [print-electronic]. 2012 Feb; 42(2-3): 627-40. PMID: 21874531, PMCID: PMC3258477, DOI: 10.1007/s00726-011-1038-4, ISSN: 1438-2199.

Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MM, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA, Chaturvedi R, Zhao Z, Wilson KT. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. PLoS ONE [print-electronic]. 2012; 7(3): e33546. PMID: 22428068, PMCID: PMC3299802, PII: PONE-D-12-00729, DOI: 10.1371/journal.pone.0033546, ISSN: 1932-6203.

Singh K, Chaturvedi R, Barry DP, Coburn LA, Asim M, Lewis ND, Piazuelo MB, Washington MK, Vitek MP, Wilson KT. The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J. Biol. Chem [print-electronic]. 2011 Feb 2/4/2011; 286(5): 3839-50. PMID: 21115487, PMCID: PMC3030385, PII: M110.176719, DOI: 10.1074/jbc.M110.176719, ISSN: 1083-351X.

Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT. Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection. PLoS ONE [print-electronic]. 2011; 6(12): e29046. PMID: 22194986, PMCID: PMC3237590, PII: PONE-D-11-18825, DOI: 10.1371/journal.pone.0029046, ISSN: 1932-6203.

Hong SK, Chaturvedi R, Piazuelo MB, Coburn LA, Williams CS, Delgado AG, Casero RA, Schwartz DA, Wilson KT. Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Inflamm. Bowel Dis. 2010 Sep; 16(9): 1557-66. PMID: 20127992, PMCID: PMC2894261, DOI: 10.1002/ibd.21224, ISSN: 1536-4844.

Hong SK, Maltz BE, Coburn LA, Slaughter JC, Chaturvedi R, Schwartz DA, Wilson KT. Increased serum levels of L-arginine in ulcerative colitis and correlation with disease severity. Inflamm. Bowel Dis. 2010 Jan; 16(1): 105-11. PMID: 19637336, PMCID: PMC2795785, DOI: 10.1002/ibd.21035, ISSN: 1536-4844.

Coburn LA, Wise PE, Schwartz DA. The successful use of adalimumab to treat active Crohn's disease of an ileoanal pouch during pregnancy. Dig. Dis. Sci [print-electronic]. 2006 Nov; 51(11): 2045-7. PMID: 17009112, DOI: 10.1007/s10620-006-9452-2, ISSN: 0163-2116.