Sara Nicole Horst, M.D.

Associate Professor

sara.n.horst@vanderbilt.edu
Faculty Appointments
Associate Professor of Medicine
Education
M.P.H., Public Health , Vanderbilt University, Nashville, TennesseeM.D., MEDICINE, Ohio State University, Columbus, OhioB.S., University of Northwestern Ohio, Lima, Ohio
Office Address
1211 21st Ave South
Medical Arts Building, Suite 220
Nashville, TN 37232
Research Description
Dr. Horst is interested in psychosocial outcomes in patients with inflammatory bowel disease, particularly in depression. She is also interested in nutritional deficiencies related to inflammatory bowel disease.
Clinical Description
Dr. Horst is a gastroenterologist who specializes in the care of inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Clinical Research Keywords
Crohn's Disease, Ulcerative Colitis
Publications
Chudy-Onwugaje K, Abutaleb A, Buchwald A, Langenberg P, Regueiro M, Schwartz DA, Tracy JK, Ghazi L, Patil SA, Quezada S, Russman K, Horst S, Beaulieu D, Quinn C, Jambaulikar G, Cross RK. Age Modifies the Association Between Depressive Symptoms and Adherence to Self-Testing With Telemedicine in Patients With Inflammatory Bowel Disease. Inflamm. Bowel Dis [print-electronic]. 2018 May 5/28/2018; PMID: 29846623, PII: 5017268, DOI: 10.1093/ibd/izy194, ISSN: 1536-4844.

Abutaleb A, Buchwald A, Chudy-Onwugaje K, Langenberg P, Regueiro M, Schwartz DA, Tracy JK, Ghazi L, Patil SA, Quezada SM, Russman KM, Quinn CC, Jambaulikar G, Beaulieu DB, Horst S, Cross RK. Inflammatory Bowel Disease Telemedicine Clinical Trial: Impact of Educational Text Messages on Disease-Specific Knowledge Over 1 Year. Inflamm. Bowel Dis [print-electronic]. 2018 May 5/18/2018; PMID: 29788137, PII: 4999387, DOI: 10.1093/ibd/izy149, ISSN: 1536-4844.

Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS, Koyama T, Zhao Z, Adams DW, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics [print-electronic]. 2018 Jan; 14(1): PMID: 29681789, PMCID: PMC5907923, DOI: 10.1007/s11306-017-1311-y, ISSN: 1573-3882.

Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS, Koyama T, Zhao Z, Adams DW, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Metabolomics [print-electronic]. 2018 Jan; 14(1): PMID: 29681789, PMCID: PMC5907923, DOI: 10.1007/s11306-017-1311-y, ISSN: 1573-3882.

Calloway A, Dalal R, Beaulieu DB, Duley C, Annis K, Gaines L, Slaughter C, Schwartz DA, Horst S. Depressive Symptoms Predict Anti-tumor Necrosis Factor Therapy Noncompliance in Patients with Inflammatory Bowel Disease. Dig. Dis. Sci [print-electronic]. 2017 Dec; 62(12): 3563-7. PMID: 29052816, PII: 10.1007/s10620-017-4800-y, DOI: 10.1007/s10620-017-4800-y, ISSN: 1573-2568.

Rubinstein S, Cornell RF, Du L, Concepcion B, Goodman S, Harrell S, Horst S, Lenihan D, Slosky D, Fogo A, Langone A. Novel pathologic scoring tools predict end-stage kidney disease in light chain (AL) amyloidosis. Amyloid [print-electronic]. 2017 Sep; 24(3): 205-11. PMID: 28758811, DOI: 10.1080/13506129.2017.1360272, ISSN: 1744-2818.

Oke O, Sethi T, Goodman S, Phillips S, Decker I, Rubinstein S, Concepcion B, Horst S, Jagasia M, Kassim A, Harrell SL, Langone A, Lenihan D, Rawling KT, Slosky D, Cornell RF. Outcomes from Autologous Hematopoietic Cell Transplantation versus Chemotherapy Alone for the Management of Light Chain Amyloidosis. Biol. Blood Marrow Transplant [print-electronic]. 2017 Sep; 23(9): 1473-7. PMID: 28546074, PII: S1083-8791(17)30467-6, DOI: 10.1016/j.bbmt.2017.05.020, ISSN: 1523-6536.

Adams DW, Gurwara S, Silver HJ, Horst SN, Beaulieu DB, Schwartz DA, Seidner DL. Sarcopenia Is Common in Overweight Patients with Inflammatory Bowel Disease and May Predict Need for Surgery. Inflamm. Bowel Dis. 2017 Jul; 23(7): 1182-6. PMID: 28410342, DOI: 10.1097/MIB.0000000000001128, ISSN: 1536-4844.

Adams DW, Gurwara S, Silver HJ, Horst SN, Beaulieu DB, Schwartz DA, Seidner DL. Sarcopenia Is Common in Overweight Patients with Inflammatory Bowel Disease and May Predict Need for Surgery. Inflamm. Bowel Dis. 2017 Jul; 23(7): 1182-6. PMID: 28410342, DOI: 10.1097/MIB.0000000000001128, ISSN: 1536-4844.

Pence IJ, Beaulieu DB, Horst SN, Bi X, Herline AJ, Schwartz DA, Mahadevan-Jansen A. Clinical characterization of in vivo inflammatory bowel disease with Raman spectroscopy. Biomed Opt Express. 2017 Feb 2/1/2017; 8(2): 524-35. PMID: 28270965, PMCID: PMC5330549, PII: 276220, DOI: 10.1364/BOE.8.000524, ISSN: 2156-7085.

Pence IJ, Beaulieu DB, Horst SN, Bi X, Herline AJ, Schwartz DA, Mahadevan-Jansen A. Clinical characterization of in vivo inflammatory bowel disease with Raman spectroscopy. Biomed Opt Express. 2017 Feb 2/1/2017; 8(2): 524-35. PMID: 28270965, PMCID: PMC5330549, PII: 276220, DOI: 10.1364/BOE.8.000524, ISSN: 2156-7085.

Coburn LA, Horst SN, Allaman MM, Brown CT, Williams CS, Hodges ME, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT. L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis. Inflamm. Bowel Dis. 2016 Aug; 22(8): 1847-58. PMID: 27104830, PMCID: PMC4956554, DOI: 10.1097/MIB.0000000000000790, ISSN: 1536-4844.

Gaines LS, Slaughter JC, Horst SN, Schwartz DA, Beaulieu DB, Haman KL, Wang L, Martin CF, Long MD, Sandler RS, Kappelman MD. Association Between Affective-Cognitive Symptoms of Depression and Exacerbation of Crohn's Disease. Am. J. Gastroenterol [print-electronic]. 2016 Jun; 111(6): 864-70. PMID: 27045927, PMCID: PMC4965803, PII: ajg201698, DOI: 10.1038/ajg.2016.98, ISSN: 1572-0241.

Harris KA, Horst S, Gadani A, Nohl A, Annis K, Duley C, Beaulieu D, Ghazi L, Schwartz DA. Patients with Refractory Crohn's Disease Successfully Treated with Ustekinumab. Inflamm. Bowel Dis. 2016 Feb; 22(2): 397-401. PMID: 26752468, DOI: 10.1097/MIB.0000000000000624, ISSN: 1536-4844.

Wiese DM, Horst SN, Brown CT, Allaman MM, Hodges ME, Slaughter JC, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA. Serum Fatty Acids Are Correlated with Inflammatory Cytokines in Ulcerative Colitis. PLoS ONE. 2016; 11(5): e0156387. PMID: 27227540, PMCID: PMC4882051, PII: PONE-D-15-55618, DOI: 10.1371/journal.pone.0156387, ISSN: 1932-6203.

Merkley SA, Beaulieu DB, Horst S, Duley C, Annis K, Nohl A, Schwartz DA. Use of Intravenous Immunoglobulin for Patients with Inflammatory Bowel Disease with Contraindications or Who Are Unresponsive to Conventional Treatments. Inflamm. Bowel Dis. 2015 Aug; 21(8): 1854-9. PMID: 25993689, DOI: 10.1097/MIB.0000000000000456, ISSN: 1536-4844.

Wiese DM, Beaulieu D, Slaughter JC, Horst S, Wagnon J, Duley C, Annis K, Nohl A, Herline A, Muldoon R, Geiger T, Wise PE, Schwartz DA. Use of Endoscopic Ultrasound to Guide Adalimumab Treatment in Perianal Crohn's Disease Results in Faster Fistula Healing. Inflamm. Bowel Dis. 2015 Jul; 21(7): 1594-9. PMID: 25985245, DOI: 10.1097/MIB.0000000000000409, ISSN: 1536-4844.

Horst S, Chao A, Rosen M, Nohl A, Duley C, Wagnon JH, Beaulieu DB, Taylor W, Gaines L, Schwartz DA. Treatment with immunosuppressive therapy may improve depressive symptoms in patients with inflammatory bowel disease. Dig. Dis. Sci [print-electronic]. 2015 Feb; 60(2): 465-70. PMID: 25274158, DOI: 10.1007/s10620-014-3375-0, ISSN: 1573-2568.

Horst S, Shelby G, Anderson J, Acra S, Polk DB, Saville BR, Garber J, Walker LS. Predicting persistence of functional abdominal pain from childhood into young adulthood. Clin. Gastroenterol. Hepatol [print-electronic]. 2014 Dec; 12(12): 2026-32. PMID: 24732284, PMCID: PMC4195814, PII: S1542-3565(14)00596-5, DOI: 10.1016/j.cgh.2014.03.034, ISSN: 1542-7714.

Horst S. Patient-reported outcomes in Crohn's disease: does race matter? [editorial]. Dig. Dis. Sci [print-electronic]. 2014 Oct; 59(10): 2354-6. PMID: 25112722, DOI: 10.1007/s10620-014-3313-1, ISSN: 1573-2568.

Horst S, Kane S. The use of biologic agents in pregnancy and breastfeeding. Gastroenterol. Clin. North Am [print-electronic]. 2014 Sep; 43(3): 495-508. PMID: 25110255, PII: S0889-8553(14)00062-4, DOI: 10.1016/j.gtc.2014.05.005, ISSN: 1558-1942.

Falaiye TO, Mitchell KR, Lu Z, Saville BR, Horst SN, Moulton DE, Schwartz DA, Wilson KT, Rosen MJ. Outcomes following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant IBD. J. Pediatr. Gastroenterol. Nutr. 2014 Feb; 58(2): 213-9. PMID: 24048170, PMCID: PMC3946904, DOI: 10.1097/MPG.0b013e3182a98df2, ISSN: 1536-4801.

Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW. MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut [print-electronic]. 2013 Oct; 62(10): 1446-55. PMID: 22833394, PMCID: PMC3663894, PII: gutjnl-2011-301439, DOI: 10.1136/gutjnl-2011-301439, ISSN: 1468-3288.

Shelby GD, Shirkey KC, Sherman AL, Beck JE, Haman K, Shears AR, Horst SN, Smith CA, Garber J, Walker LS. Functional abdominal pain in childhood and long-term vulnerability to anxiety disorders. Pediatrics [print-electronic]. 2013 Sep; 132(3): 475-82. PMID: 23940244, PMCID: PMC3876748, PII: peds.2012-2191, DOI: 10.1542/peds.2012-2191, ISSN: 1098-4275.

Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KT. High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. PLoS ONE. 2013; 8(12): e82300. PMID: 24367513, PMCID: PMC3867379, PII: PONE-D-13-38373, DOI: 10.1371/journal.pone.0082300, ISSN: 1932-6203.

Kane SV, Horst S, Sandborn WJ, Becker B, Neis B, Moscandrew M, Hanson KA, Tremaine WJ, Bruining DH, Faubion WA, Pardi DS, Harmsen WS, Zinsmeister AR, Loftus EV. Natalizumab for moderate to severe Crohn's disease in clinical practice: the Mayo Clinic Rochester experience. Inflamm. Bowel Dis [print-electronic]. 2012 Dec; 18(12): 2203-8. PMID: 22419661, DOI: 10.1002/ibd.22943, ISSN: 1536-4844.

Crooke PS, Tossberg JT, Horst SN, Tauscher JL, Henderson MA, Beaulieu DB, Schwartz DA, Olsen NJ, Aune TM. Using gene expression data to identify certain gastro-intestinal diseases. J Clin Bioinforma. 2012 Nov 11/21/2012; 2(1): 20. PMID: 23171526, PMCID: PMC3599448, PII: 2043-9113-2-20, DOI: 10.1186/2043-9113-2-20, ISSN: 2043-9113.

Horst SN, Kane S. Multi-Matrix System (MMX®) mesalamine for the treatment of mild-to-moderate ulcerative colitis. Expert Opin Pharmacother [print-electronic]. 2012 Oct; 13(15): 2225-32. PMID: 22970981, DOI: 10.1517/14656566.2012.723691, ISSN: 1744-7666.

Geiger TM, Horst S, Muldoon R, Wise PE, Enrenfeld J, Poulose B, Herline AJ. Perioperative core body temperatures effect on outcome after colorectal resections. Am Surg. 2012 May; 78(5): 607-12. PMID: 22546136, ISSN: 1555-9823.

Dengler-Crish CM, Horst SN, Walker LS. Somatic complaints in childhood functional abdominal pain are associated with functional gastrointestinal disorders in adolescence and adulthood. J. Pediatr. Gastroenterol. Nutr. 2011 Feb; 52(2): 162-5. PMID: 21150653, PMCID: PMC3040560, DOI: 10.1097/MPG.0b013e3181ec1d2e, ISSN: 1536-4801.

Horst S, Kocak E, Young D, Mantil J, Martin EW. Abdominal positron-emission tomography lesions with increased standardized uptake values correlate with intraoperative findings. Am. J. Surg. 2006 Jan; 191(1): 39-44. PMID: 16399104, PII: S0002-9610(05)00792-0, DOI: 10.1016/j.amjsurg.2005.10.001, ISSN: 0002-9610.

Xiao J, Horst S, Hinkle G, Cao X, Kocak E, Fang J, Young D, Khazaeli M, Agnese D, Sun D, Martin E. Pharmacokinetics and clinical evaluation of 125I-radiolabeled humanized CC49 monoclonal antibody (HuCC49deltaC(H)2) in recurrent and metastatic colorectal cancer patients. Cancer Biother. Radiopharm. 2005 Feb; 20(1): 16-26. PMID: 15778575, DOI: 10.1089/cbr.2005.20.16, ISSN: 1084-9785.