Phillip E. Williams

Research Professor

phil.williams@vanderbilt.edu
Faculty Appointments
Research Professor of Surgery
Education
B.S., Middle Tennessee State University, Murfreesboro, Tennessee
Office Address
CC-2306 MCN
TN 2733
Publications
Pencek RR, Koyama Y, Lacy DB, James FD, Fueger PT, Jabbour K, Williams PE, Wasserman DH. Prior exercise enhances passive absorption of intraduodenal glucose. J. Appl. Physiol [print-electronic]. 2003 Sep; 95(3): 1132-8. PMID: 12740315, PII: 01172.2002, DOI: 10.1152/japplphysiol.01172.2002, ISSN: 8750-7587.

Pencek RR, James F, Lacy DB, Jabbour K, Williams PE, Fueger PT, Wasserman DH. Interaction of insulin and prior exercise in control of hepatic metabolism of a glucose load. Diabetes. 2003 Aug; 52(8): 1897-903. PMID: 12882903, ISSN: 0012-1797.

Cardin S, Walmsley K, Neal DW, Williams PE, Cherrington AD. Involvement of the vagus nerves in the regulation of basal hepatic glucose production in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 2002 Nov; 283(5): E958-64. PMID: 12376322, DOI: 10.1152/ajpendo.00566.2001, ISSN: 0193-1849.

Pencek RR, Koyama Y, Lacy DB, James FD, Fueger PT, Jabbour K, Williams PE, Wasserman DH. Transporter-mediated absorption is the primary route of entry and is required for passive absorption of intestinal glucose into the blood of conscious dogs. J. Nutr. 2002 Jul; 132(7): 1929-34. PMID: 12097672, ISSN: 0022-3166.

Sherck SM, Shiota M, Saccomando J, Cardin S, Allen EJ, Hastings JR, Neal DW, Williams PE, Cherrington AD. Pancreatic response to mild non-insulin-induced hypoglycemia does not involve extrinsic neural input. Diabetes. 2001 Nov; 50(11): 2487-96. PMID: 11679426, ISSN: 0012-1797.

Koyama Y, Coker RH, Denny JC, Lacy DB, Jabbour K, Williams PE, Wasserman DH. Role of carotid bodies in control of the neuroendocrine response to exercise. Am. J. Physiol. Endocrinol. Metab. 2001 Oct; 281(4): E742-8. PMID: 11551850, ISSN: 0193-1849.

Gresham JD, Okamura K, Williams PE, Jabbour K, Flakoll PJ. Gastrointestinal tract, hepatic, hindlimb, and renal recovery of CO(2) in vivo. J. Appl. Physiol. 2000 Nov; 89(5): 2000-6. PMID: 11053355, ISSN: 8750-7587.

Koyama Y, Coker RH, Stone EE, Lacy DB, Jabbour K, Williams PE, Wasserman DH. Evidence that carotid bodies play an important role in glucoregulation in vivo. Diabetes. 2000 Sep; 49(9): 1434-42. PMID: 10969826, ISSN: 0012-1797.

Coker RH, Lacy DB, Williams PE, Wasserman DH. Hepatic alpha- and beta-adrenergic receptors are not essential for the increase in R(a) during exercise in diabetes. Am. J. Physiol. Endocrinol. Metab. 2000 Mar; 278(3): E444-51. PMID: 10710498, ISSN: 0193-1849.

Coker RH, Koyama Y, Lacy DB, Williams PE, Rhèaume N, Wasserman DH. Pancreatic innervation is not essential for exercise-induced changes in glucagon and insulin or glucose kinetics. Am. J. Physiol. 1999 Dec; 277(6 Pt 1): E1122-9. PMID: 10600803, ISSN: 0002-9513.

Geevarghese SK, Bradley AL, Atkinson J, Wright JK, Chapman WC, Van Buren DH, Blair KT, Hutchins CH, Jabbour K, Phillips J, Williams PE, Pinson CW. Comparison of arcuate-legged clipped versus sutured hepatic artery, portal vein, and bile duct anastomoses. Am Surg. 1999 Apr; 65(4): 311-6. PMID: 10190352, ISSN: 0003-1348.

Geevarghese SK, Flakoll P, Bradley AL, Wright JK, Chapman WC, Van Buren D, Sika M, Blair KT, Jabbour K, Williams PE, Hutchins CH, Phillips JL, Pinson CW. The effect of nutritional and hormonal supplementation on protein synthesis immediately after liver transplantation. J. Surg. Res. 1999 Feb; 81(2): 196-200. PMID: 9927540, PII: S0022-4804(98)95509-3, DOI: 10.1006/jsre.1998.5509, ISSN: 0022-4804.

Borel MJ, Williams PE, Jabbour K, Levenhagen D, Kaizer E, Flakoll PJ. Parenteral glutamine infusion alters insulin-mediated glucose metabolism. JPEN J Parenter Enteral Nutr. 1998 Sep; 22(5): 280-5. PMID: 9739030, ISSN: 0148-6071.

Bradley AL, Sika M, Becker YT, Blair KT, Jabbour K, Williams PE, Phillips J, Chapman WC, Wright JK, Flakoll PJ, Pinson CW. Net hepatic glucose output is normal on postoperative day 1 after liver transplantation. Am Surg. 1998 Mar; 64(3): 255-8. PMID: 9520818, ISSN: 0003-1348.

Halseth AE, Flakoll PJ, Reed EK, Messina AB, Krishna MG, Lacy DB, Williams PE, Wasserman DH. Effect of physical activity and fasting on gut and liver proteolysis in the dog. Am. J. Physiol. 1997 Dec; 273(6 Pt 1): E1073-82. PMID: 9435521, ISSN: 0002-9513.

Borel MJ, Williams PE, Jabbour K, Hibbard JC, Flakoll PJ. Maintaining muscle protein anabolism after a metabolic stress: role of dextrose vs. amino acid availability. Am. J. Physiol. 1997 Jan; 272(1 Pt 1): E36-44. PMID: 9038849, ISSN: 0002-9513.

Drougas JG, Barnard SE, Wright JK, Sika M, Lopez RR, Stokes KA, Williams PE, Pinson CW. A model for the extended studies of hepatic hemodynamics and metabolism in swine. Lab. Anim. Sci. 1996 Dec; 46(6): 648-55. PMID: 9001178, ISSN: 0023-6764.

Connolly CC, Ivy RE, Adkins-Marshall BA, Dobbins RL, Neal DW, Williams PE, Cherrington AD. Counterregulation by epinephrine and glucagon during insulin-induced hypoglycemia in the conscious dog. Diabetes Res. Clin. Pract. 1996 Mar; 31(1-3): 45-56. PMID: 8792101, ISSN: 0168-8227.

Flakoll PJ, Borel MJ, Wentzel LS, Williams PE, Lacy DB, Abumrad NN. The role of glucagon in the control of protein and amino acid metabolism in vivo. Metab. Clin. Exp. 1994 Dec; 43(12): 1509-16. PMID: 7990704, ISSN: 0026-0495.

Wasserman DH, Ruzumna PA, Bracy DP, Lacy DB, Boothe HW, Williams PE, Abumrad NN. Impact of suprapharmacological androgenic steroid administration on basal and insulin-stimulated glucose and amino acid metabolism. Metab. Clin. Exp. 1994 Oct; 43(10): 1266-74. PMID: 7934979, PII: 0026-0495(94)90221-6, ISSN: 0026-0495.

Goldstein RE, Reed GW, Wasserman DH, Williams PE, Lacy DB, Buckspan R, Abumrad NN, Cherrington AD. The effects of acute elevations in plasma cortisol levels on alanine metabolism in the conscious dog. Metab. Clin. Exp. 1992 Dec; 41(12): 1295-303. PMID: 1461135, ISSN: 0026-0495.

Hendrick GK, Wasserman DH, Frizzell RT, Williams PE, Lacy DB, Jaspan JB, Cherrington AD. Importance of basal glucagon in maintaining hepatic glucose production during a prolonged fast in conscious dogs. Am. J. Physiol. 1992 Sep; 263(3 Pt 1): E541-9. PMID: 1415534, ISSN: 0002-9513.

Wasserman DH, Lacy DB, Bracy D, Williams PE. Metabolic regulation in peripheral tissues and transition to increased gluconeogenic mode during prolonged exercise. Am. J. Physiol. 1992 Aug; 263(2 Pt 1): E345-54. PMID: 1514617, ISSN: 0002-9513.

Adkins-Marshall B, Pagliassotti MJ, Asher JR, Connolly CC, Neal DW, Williams PE, Myers SR, Hendrick GK, Adkins RB, Cherrington AD. Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am. J. Physiol. 1992 May; 262(5 Pt 1): E679-86. PMID: 1590377, ISSN: 0002-9513.

Connolly CC, Steiner KE, Stevenson RW, Neal DW, Williams PE, Alberti KG, Cherrington AD. Regulation of glucose metabolism by norepinephrine in conscious dogs. Am. J. Physiol. 1991 Dec; 261(6 Pt 1): E764-72. PMID: 1767837, ISSN: 0002-9513.

Connolly CC, Steiner KE, Stevenson RW, Neal DW, Williams PE, Alberti KG, Cherrington AD. Regulation of lipolysis and ketogenesis by norepinephrine in conscious dogs. Am. J. Physiol. 1991 Oct; 261(4 Pt 1): E466-72. PMID: 1928338, ISSN: 0002-9513.

Nammour TM, Williams PE, Badr KF, Abumrad NN, Jacobson HR. The amino acid-induced alteration in renal hemodynamics is glucagon independent. J. Am. Soc. Nephrol. 1991 Aug; 2(2): 164-71. PMID: 1954329, ISSN: 1046-6673.

Stevenson RW, Steiner KE, Connolly CC, Fuchs H, Alberti KG, Williams PE, Cherrington AD. Dose-related effects of epinephrine on glucose production in conscious dogs. Am. J. Physiol. 1991 Mar; 260(3 Pt 1): E363-70. PMID: 2003590, ISSN: 0002-9513.

Wasserman DH, Geer RJ, Williams PE, Becker T, Lacy DB, Abumrad NN. Interaction of gut and liver in nitrogen metabolism during exercise. Metab. Clin. Exp. 1991 Mar; 40(3): 307-14. PMID: 1672034, PII: 0026-0495(91)90115-D, ISSN: 0026-0495.

Myers SR, Diamond MP, Adkins-Marshall BA, Williams PE, Stinsen R, Cherrington AD. Effects of small changes in glucagon on glucose production during a euglycemic, hyperinsulinemic clamp. Metab. Clin. Exp. 1991 Jan; 40(1): 66-71. PMID: 1984573, PII: 0026-0495(91)90194-2, ISSN: 0026-0495.

Steiner KE, Williams PE, Lacy WW, Cherrington AD. Effects of insulin on glucagon-stimulated glucose production in the conscious dog. Metab. Clin. Exp. 1990 Dec; 39(12): 1325-33. PMID: 2246975, ISSN: 0026-0495.

Wasserman DH, Williams PE, Lacy DB, Bracy D, Cherrington AD. Hepatic nerves are not essential to the increase in hepatic glucose production during muscular work. Am. J. Physiol. 1990 Aug; 259(2 Pt 1): E195-203. PMID: 2200275, ISSN: 0002-9513.

Hendrick GK, Frizzell RT, Williams PE, Cherrington AD. Effect of hyperglucagonemia on hepatic glycogenolysis and gluconeogenesis after a prolonged fast. Am. J. Physiol. 1990 May; 258(5 Pt 1): E841-9. PMID: 2185665, ISSN: 0002-9513.

Adkins-Marshall BA, Myers SR, Hendrick GK, Williams PE, Triebwasser K, Floyd B, Cherrington AD. Interaction between insulin and glucose-delivery route in regulation of net hepatic glucose uptake in conscious dogs. Diabetes. 1990 Jan; 39(1): 87-95. PMID: 2210065, ISSN: 0012-1797.

Radosevich PM, Nash JA, Lacy DB, O'Donovan C, Williams PE, Abumrad NN. Effects of low- and high-intensity exercise on plasma and cerebrospinal fluid levels of ir-beta-endorphin, ACTH, cortisol, norepinephrine and glucose in the conscious dog. Brain Res. 1989 Sep 9/25/1989; 498(1): 89-98. PMID: 2551459, ISSN: 0006-8993.

Nash JA, Radosevich PM, Lacy DB, Rizk N, Hourani H, Williams PE, Abumrad NN. Effects of naloxone on glucose homeostasis during insulin-induced hypoglycemia. Am. J. Physiol. 1989 Sep; 257(3 Pt 1): E367-73. PMID: 2528911, ISSN: 0002-9513.

Abumrad NN, Morse EL, Lochs H, Williams PE, Adibi SA. Possible sources of glutamine for parenteral nutrition: impact on glutamine metabolism. Am. J. Physiol. 1989 Aug; 257(2 Pt 1): E228-34. PMID: 2504051, ISSN: 0002-9513.

Wasserman DH, Williams PE, Lacy DB, Goldstein RE, Cherrington AD. Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am. J. Physiol. 1989 Apr; 256(4 Pt 1): E500-9. PMID: 2650562, ISSN: 0002-9513.

Wasserman DH, Lacy DB, Goldstein RE, Williams PE, Cherrington AD. Exercise-induced fall in insulin and increase in fat metabolism during prolonged muscular work. Diabetes. 1989 Apr; 38(4): 484-90. PMID: 2647555, ISSN: 0012-1797.

Radosevich PM, Lacy DB, Brown LL, Williams PE, Abumrad NN. Central effects of beta-endorphins on glucose homeostasis in the conscious dog. Am. J. Physiol. 1989 Feb; 256(2 Pt 1): E322-30. PMID: 2521986, ISSN: 0002-9513.

Biggers DW, Myers SR, Neal D, Stinson R, Cooper NB, Jaspan JB, Williams PE, Cherrington AD, Frizzell RT. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes. 1989 Jan; 38(1): 7-16. PMID: 2642436, ISSN: 0012-1797.

Frizzell RT, Hendrick GK, Brown LL, Lacy DB, Donahue EP, Carr RK, Williams PE, Parlow AF, Stevenson RW, Cherrington AD. Stimulation of glucose production through hormone secretion and other mechanisms during insulin-induced hypoglycemia. Diabetes. 1988 Nov; 37(11): 1531-41. PMID: 3053302, ISSN: 0012-1797.

Radosevich PM, Lacy DB, Brown LL, Williams PE, Abumrad NN. Effects of insulin-induced hypoglycemia on plasma and cerebrospinal fluid levels of ir-beta-endorphins, ACTH, cortisol, norepinephrine, insulin and glucose in the conscious dog. Brain Res. 1988 Aug 8/23/1988; 458(2): 325-38. PMID: 2850080, PII: 0006-8993(88)90475-1, ISSN: 0006-8993.

Frizzell RT, Hendrick GK, Biggers DW, Lacy DB, Donahue DP, Green DR, Carr RK, Williams PE, Stevenson RW, Cherrington AD. Role of gluconeogenesis in sustaining glucose production during hypoglycemia caused by continuous insulin infusion in conscious dogs. Diabetes. 1988 Jun; 37(6): 749-59. PMID: 3289995, ISSN: 0012-1797.

Brown LL, Williams PE, Becker TA, Ensley RJ, May ME, Abumrad NN. Rapid high-performance liquid chromatographic method to measure plasma leucine: importance in the study of leucine kinetics in vivo. J. Chromatogr. 1988 Apr 4/29/1988; 426(2): 370-5. PMID: 3292555.

Wasserman DH, Williams PE, Lacy DB, Green DR, Cherrington AD. Importance of intrahepatic mechanisms to gluconeogenesis from alanine during exercise and recovery. Am. J. Physiol. 1988 Apr; 254(4 Pt 1): E518-25. PMID: 3281473, ISSN: 0002-9513.

Kulaylat MN, Frexes-Steed M, Geer R, Williams PE, Abumrad NN. The role of leucine in hepatic ketogenesis. Surgery. 1988 Mar; 103(3): 351-60. PMID: 2894077, PII: 0039-6060(88)90273-5, ISSN: 0039-6060.

Diamond MP, Rollings RC, Steiner KE, Williams PE, Lacy WW, Cherrington AD. Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog. Metab. Clin. Exp. 1988 Jan; 37(1): 28-33. PMID: 3275858, PII: 0026-0495(88)90025-X, ISSN: 0026-0495.

Wasserman DH, Lacy DB, Green DR, Williams PE, Cherrington AD. Dynamics of hepatic lactate and glucose balances during prolonged exercise and recovery in the dog. J. Appl. Physiol. 1987 Dec; 63(6): 2411-7. PMID: 3325489, ISSN: 8750-7587.