Philip David Charles, M.D.


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Faculty Appointments
Professor of Neurology
M.D., Medicine, Vanderbilt University, Nashville, TennesseeB.S., Computer Science and Mathemathics, Vanderbilt University, Nashville, Tennessee
Office Address
Department of Neurology
Suite A-1106 MCN
1161 21st Avenue South
Nashville, TN 37232
Research Description
Research interests include the treatment of early stage Parkinson's disease with deep brain stimulation and the treatment of spasticity and cervical dystonia with botulinum toxin injection.
Clinical Description
Clinical interests include the treatment of children and adults with spasticity and adults with Parkinson's disease, tremor, and dystonia.
Research Keywords
Parkinson's disease, cervical dystonia, spasticity, deep brain stimulation, botulinum toxin injection
Clinical Research Keywords
Movement Disorders, Parkinson's Disease, Dystonia, Tremor, Spasticity
Harper KA, Butler EC, Hacker ML, Naik A, Eoff BR, Phibbs FT, Isaacs DA, Gallion SJ, Thomas EP, Scott JL, Ploucher S, Meystedt JC, McLeod ME, Charles PD. A comparative evaluation of telehealth and direct assessment when screening for spasticity in residents of two long-term care facilities. Clin Rehabil [print-electronic]. 2021 Apr; 35(4): 589-94. PMID: 33040604, DOI: 10.1177/0269215520963845, ISSN: 1477-0873.

Fischer DL, Auinger P, Goudreau JL, Cole-Strauss A, Kieburtz K, Elm JJ, Hacker ML, Charles PD, Lipton JW, Pickut BA, Sortwell CE. BDNF rs6265 Variant Alters Outcomes with Levodopa in Early-Stage Parkinson's Disease. Neurotherapeutics [print-electronic]. 2020 Oct; 17(4): 1785-95. PMID: 33215284, PMCID: PMC7851242, PII: 10.1007/s13311-020-00965-9, DOI: 10.1007/s13311-020-00965-9, ISSN: 1878-7479.

Bick SK, Folley BS, Mayer JS, Park S, Charles PD, Camalier CR, Pallavaram S, Konrad PE, Neimat JS. Subthalamic Nucleus Deep Brain Stimulation Alters Prefrontal Correlates of Emotion Induction. Neuromodulation [print-electronic]. 2017 Apr; 20(3): 233-7. PMID: 27730703, PMCID: PMC5389909, DOI: 10.1111/ner.12537, ISSN: 1525-1403.

Charles PD, Manack Adams A, Davis T, Bradley K, Schwartz M, Brin MF, Patel AT. Neck Pain and Cervical Dystonia: Treatment Outcomes from CD PROBE (Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy). Pain Pract [print-electronic]. 2016 Feb 2/23/2016; PMID: 26910788, DOI: 10.1111/papr.12408, ISSN: 1533-2500.

Tielbur BR, Rice Cella DE, Currie A, Roach JD, Mattingly B, Boone J, Watwood C, McGauran A, Kirshner HS, Charles PD. Discharge huddle outfitted with mobile technology improves efficiency of transitioning stroke patients into follow-up care. Am J Med Qual [print-electronic]. 2015 Jan; 30(1): 36-44. PMID: 24316727, PII: 1062860613510964, DOI: 10.1177/1062860613510964, ISSN: 1555-824X.

Charles PD, Adler CH, Stacy M, Comella C, Jankovic J, Manack Adams A, Schwartz M, Brin MF. Cervical dystonia and pain: characteristics and treatment patterns from CD PROBE (Cervical Dystonia Patient Registry for Observation of OnabotulinumtoxinA Efficacy). J. Neurol [print-electronic]. 2014 Jul; 261(7): 1309-19. PMID: 24752807, PMCID: PMC4098041, DOI: 10.1007/s00415-014-7343-6, ISSN: 1432-1459.

Hedera P, Davis TL, Phibbs FT, Charles PD, LeDoux MS. FUS in familial essential tremor - the search for common causes is still on. Parkinsonism Relat. Disord [print-electronic]. 2013 Sep; 19(9): 818-20. PMID: 23660545, PII: S1353-8020(13)00154-5, DOI: 10.1016/j.parkreldis.2013.04.009, ISSN: 1873-5126.

Hedera P, Phibbs FT, Dolhun R, Charles PD, Konrad PE, Neimat JS, Davis TL. Surgical targets for dystonic tremor: considerations between the globus pallidus and ventral intermediate thalamic nucleus. Parkinsonism Relat. Disord [print-electronic]. 2013 Jul; 19(7): 684-6. PMID: 23611688, PII: S1353-8020(13)00126-0, DOI: 10.1016/j.parkreldis.2013.03.010, ISSN: 1873-5126.

Charles PD, Dolhun RM, Gill CE, Davis TL, Bliton MJ, Tramontana MG, Salomon RM, Wang L, Hedera P, Phibbs FT, Neimat JS, Konrad PE. Deep brain stimulation in early Parkinson's disease: enrollment experience from a pilot trial. Parkinsonism Relat. Disord [print-electronic]. 2012 Mar; 18(3): 268-73. PMID: 22104012, PMCID: PMC3288479, PII: S1353-8020(11)00381-6, DOI: 10.1016/j.parkreldis.2011.11.001, ISSN: 1873-5126.

Kahn E, D'Haese PF, Dawant B, Allen L, Kao C, Charles PD, Konrad P. Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trial. J. Neurol. Neurosurg. Psychiatr [print-electronic]. 2012 Feb; 83(2): 164-70. PMID: 21890575, PMCID: PMC3733009, PII: jnnp-2011-300008, DOI: 10.1136/jnnp-2011-300008, ISSN: 1468-330X.

Phillips L, Litcofsky KA, Pelster M, Gelfand M, Ullman MT, Charles PD. Subthalamic nucleus deep brain stimulation impacts language in early Parkinson's disease. PLoS ONE [print-electronic]. 2012; 7(8): e42829. PMID: 22880117, PMCID: PMC3413674, PII: PONE-D-11-25429, DOI: 10.1371/journal.pone.0042829, ISSN: 1932-6203.

Molinari AL, Gill CE, Taylor HM, Charles PD. Barriers to conducting research with community-dwelling adults who have intellectual disabilities. Intellect Dev Disabil. 2011 Oct; 49(5): 392-6. PMID: 21905834, DOI: 10.1352/1934-9556-49.5.392, ISSN: 1934-9556.

Remple MS, Bradenham CH, Kao CC, Charles PD, Neimat JS, Konrad PE. Subthalamic nucleus neuronal firing rate increases with Parkinson's disease progression. Mov. Disord [print-electronic]. 2011 Aug 8/1/2011; 26(9): 1657-62. PMID: 21542021, PMCID: PMC3151310, DOI: 10.1002/mds.23708, ISSN: 1531-8257.

Charles PD, Gill CE, Taylor HM, Putman MS, Blair CR, Roberts AG, Ayers GD, Konrad PE. Spasticity treatment facilitates direct care delivery for adults with profound intellectual disability. Mov. Disord. 2010 Mar 3/15/2010; 25(4): 466-73. PMID: 20131401, DOI: 10.1002/mds.22995, ISSN: 1531-8257.

Hedera P, Phibbs FT, Fang JY, Cooper MK, Charles PD, Davis TL. Clustering of dystonia in some pedigrees with autosomal dominant essential tremor suggests the existence of a distinct subtype of essential tremor. BMC Neurol. 2010; 10: 66. PMID: 20670416, PMCID: PMC2918572, PII: 1471-2377-10-66, DOI: 10.1186/1471-2377-10-66, ISSN: 1471-2377.

Hedera P, Fang JY, Phibbs F, Cooper MK, Charles PD, Davis TL. Positive family history of essential tremor influences the motor phenotype of Parkinson's disease. Mov. Disord. 2009 Nov 11/15/2009; 24(15): 2285-8. PMID: 19795470, DOI: 10.1002/mds.22772, ISSN: 1531-8257.

Charles PD, Gill CE, Davis TL, Konrad PE, Benabid AL. Is deep brain stimulation neuroprotective if applied early in the course of PD?. Nat Clin Pract Neurol [print-electronic]. 2008 Aug; 4(8): 424-6. PMID: 18594505, PII: ncpneuro0848, DOI: 10.1038/ncpneuro0848, ISSN: 1745-8358.

Schadt CR, Charles PD, Davis TL, Konrad PE. Thalamotomy, DBS-Vim, and DBS-GPi for generalized dystonia: a case report. Tenn Med. 2007 Feb; 100(2): 38-9. PMID: 17378506, ISSN: 1088-6222.

Schadt CR, Cox KL, Tramontana MG, Byrne DW, Davis TL, Fang JY, Konrad PE, Padaliya B, Mutter RW, Gill CE, Richardson CR, Charles PD. Depression and intelligence in patients with Parkinson's disease and deep-brain stimulation. J Natl Med Assoc. 2006 Jul; 98(7): 1121-5. PMID: 16895282, PMCID: PMC2569473, ISSN: 1943-4693.

Gill CE, Taylor HM, Lin KT, Padaliya BB, Newman WJ, Abramovitch AI, Richardson CR, Charles PD. Difficulty in securing treatment for degenerative hip disease in a patient with Down syndrome: the gap remains open. J Natl Med Assoc. 2006 Jan; 98(1): 93-6. PMID: 16532986, PMCID: PMC2594795, ISSN: 1943-4693.

Abramovitch A, Newman W, Padaliya B, Gill C, Charles PD. The cost of medical education in an ambulatory neurology clinic. J Natl Med Assoc. 2005 Sep; 97(9): 1288-90. PMID: 16296220, PMCID: PMC2594794, ISSN: 1943-4693.

Schadt CR, Duffis EI, Charles PD. Pharmacological treatment of disabling tremor. Expert Opin Pharmacother. 2005 Mar; 6(3): 419-28. PMID: 15794733, PII: EOP060307, DOI: 10.1517/14656566.6.3.419, ISSN: 1744-7666.

Charles PD, Padaliya BB, Newman WJ, Gill CE, Covington CD, Fang JY, So SA, Tramontana MG, Konrad PE, Davis TL. Deep brain stimulation of the subthalamic nucleus reduces antiparkinsonian medication costs. Parkinsonism Relat. Disord. 2004 Dec; 10(8): 475-9. PMID: 15542007, PII: S1353802004000963, DOI: 10.1016/j.parkreldis.2004.05.006, ISSN: 1353-8020.

Charles PD. Botulinum neurotoxin serotype A: a clinical update on non-cosmetic uses. Am J Health Syst Pharm. 2004 Nov 11/15/2004; 61(22 Suppl 6): S11-23. PMID: 15598005, ISSN: 1079-2082.

Newman WJ, Davis TL, Padaliya BB, Covington CD, Gill CE, Abramovitch AI, Charles PD. Botulinum toxin type A therapy during pregnancy. Mov. Disord. 2004 Nov; 19(11): 1384-5. PMID: 15389988, DOI: 10.1002/mds.20205, ISSN: 0885-3185.

Padaliya BB, Davis TL, Newman WJ, Konrad PE, Covington CD, Gill CE, Abramovitch AI, Charles PD. Bilateral globus pallidus internus deep brain stimulation therapy for primary generalized dystonia. Tenn Med. 2004 Jul; 97(7): 317-8. PMID: 15359520, ISSN: 1088-6222.

Hogan P, Charles PD, Wooten Watts M, Massey JM, Miller T, Mackowiack J. Severity and impact of xerostomia in patients treated with botulinum toxin type b for cervical dystonia: Observations on the quality of life of patients with xerostomia. Curr Ther Res Clin Exp. 2004 Mar; 65(2): 161-71. PMID: 24936114, PMCID: PMC4052966, PII: S0011-393X(04)90030-6, DOI: 10.1016/S0011-393X(04)90030-6, ISSN: 0011-393X.

Pfister AA, Roberts AG, Taylor HM, Noel-Spaudling S, Damian MM, Charles PD. Spasticity in adults living in a developmental center. Arch Phys Med Rehabil. 2003 Dec; 84(12): 1808-12. PMID: 14669188, PII: S000399930300368X, ISSN: 0003-9993.

Gill C, Covington C, Padaliya B, Newman W, Pomeroy T, Charles PD. Successful treatment of childhood spasticity secondary to cerebral palsy using Botox. Tenn Med. 2003 Nov; 96(11): 511-3. PMID: 14635360, ISSN: 1088-6222.

Roberts AG, Graves CR, Konrad PE, Groomes TE, Pfister AA, Damian MM, Charles PD. Intrathecal baclofen pump implantation during pregnancy. Neurology. 2003 Oct 10/28/2003; 61(8): 1156-7. PMID: 14581694, ISSN: 1526-632X.

Covington C, Taylor H, Gill C, Padaliya B, Newman W, Smart JR, Charles PD. Prolonged survival in hydranencephaly: a case report. Tenn Med. 2003 Sep; 96(9): 423-4. PMID: 14513530, ISSN: 1088-6222.

Damian M, Davis TL, Konrad PE, Roberts AG, Pfister AA, Charles PD. Deep brain stimulation: a new treatment for Parkinson's disease. Tenn Med. 2003 Jan; 96(1): 33-5. PMID: 12602053, ISSN: 1088-6222.

Charles PD, Esper GJ, Davis TL. A definition of "on": patient diaries compared to the UPDRS. Parkinsonism Relat. Disord. 1999 Sep; 5(3): 99-101. PMID: 18591127, PII: S1353-8020(99)00024-3, ISSN: 1353-8020.

Charles PD, Esper GJ, Davis TL, Maciunas RJ, Robertson D. Classification of tremor and update on treatment. Am Fam Physician. 1999 Mar 3/15/1999; 59(6): 1565-72. PMID: 10193597, ISSN: 0002-838X.

Austin MT, Davis TL, Robertson D, Charles PD. Multiple system atrophy: clinical presentation and diagnosis. Tenn Med. 1999 Feb; 92(2): 55-7. PMID: 9932532, ISSN: 1088-6222.

Charles PD, Scherokman B, Jozefowicz RF. How much neurology should a medical student learn? a position statement of the AAN Undergraduate Education Subcommittee. Acad Med. 1999 Jan; 74(1): 23-6. PMID: 9934290, ISSN: 1040-2446.

Charles PD. A perspective on financial incentives in health care. Tenn Med. 1998 Oct; 91(10): 386-7. PMID: 9780819, ISSN: 1088-6222.

Charles PD, Maciunas RJ, Davis TL, Drowota FR, Truett AA, Giles JT, Cheney JT, Robertson D. Thalamic stimulation: an innovative treatment for tremor. Tenn Med. 1997 Jul; 90(7): 275-7. PMID: 9216239, ISSN: 1088-6222.

Charles PD, Davis TL, Shannon KM, Hook MA, Warner JS. Tongue protrusion dystonia: treatment with botulinum toxin. South. Med. J. 1997 May; 90(5): 522-5. PMID: 9160072, ISSN: 0038-4348.

Charles PD, Abou-Khalil B, Atkinson DS, Bakar M, Mayville CL, Kirshner HS. Occipital pole area and language dominance. J Neuroimaging. 1997 Apr; 7(2): 89-91. PMID: 9128446, ISSN: 1051-2284.

Esper GJ, Charles PD, Davis TL, Robertson D. Adult-onset focal dystonias: presentation and treatment options. Tenn Med. 1997 Jan; 90(1): 18-20. PMID: 8997156, ISSN: 1088-6222.

Atkinson DS, Abou-Khalil B, Charles PD, Welch L. Midsagittal corpus callosum area, intelligence, and language dominance in epilepsy. J Neuroimaging. 1996 Oct; 6(4): 235-9. PMID: 8903076, ISSN: 1051-2284.

Charles PD, Davis TL. Drug therapy for Parkinson's disease. South. Med. J. 1996 Sep; 89(9): 851-6. PMID: 8790306, ISSN: 0038-4348.

Davis TL, Charles PD, Burns RS. Clonazepam-sensitive intermittent dystonic tremor. South. Med. J. 1995 Oct; 88(10): 1069-71. PMID: 7481966, ISSN: 0038-4348.

Charles PD, Davis TL, Robertson D, Fenichel GM. Dystonia and unique muscle features. A 23-year follow-up and correction of diagnosis in two brothers. Arch. Neurol. 1995 Aug; 52(8): 825-6. PMID: 7639635, ISSN: 0003-9942.

Charles PD, Abou-Khalil R, Abou-Khalil B, Wertz RT, Ashmead DH, Welch L, Kirshner HS. MRI asymmetries and language dominance. Neurology. 1994 Nov; 44(11): 2050-4. PMID: 7969958, ISSN: 0028-3878.

Charles PD, Davis TL. Sumatriptan for migraine. Am. J. Med. Sci. 1994 Jun; 307(6): 445-7. PMID: 8198152, ISSN: 0002-9629.

Charles PD, Fenichel GM. Sneddon and antiphospholipid antibody syndromes causing bilateral thalamic infarction. Pediatr. Neurol. 1994 May; 10(3): 262-3. PMID: 8060434, PII: 0887-8994(94)90037-X, ISSN: 0887-8994.