J. Harold Helderman, M.D.


Faculty Appointments
Professor of Medicine Professor of Pathology, Microbiology and Immunology
M.D., State University of New York, Downstate Medical Center, Brooklyn, New YorkB.A., University of Rochester, Rochester, New York
Office Address
S-3305 MCN, Vanderbilt University Medical Center
KY 2372
Research Description
Dr. Helderman is the Medical Director of the multi-organ, multi-disciplinary Vanderbilt Transplant Center. He attends on the renal transplant service managing in-patients with fresh renal transplants and problems of previously placed organs. He maintains two out-patient transplant clinics per week at Vanderbilt and a transplant clinic once a month at St. Thomas. His clinical research interests have involved the development of new immunosuppressive strategies, the pathogenesis and treatment of chronic rejection, the pathogenesis and management of medical complications of transplantation including infection, neoplasia, metabolic disorders including diabetes and bone disease, and cardiac disease. Dr. Helderman is nationally recognized as a leader in transplantation. He serves as the President of the American Society of Transplant Physicians, is on a national board of the United Network of Organ Sharing, represents transplantation on the Council of the American Kidney Societies. He is the Associate Editor of the American Journal of Kidney Disease and on the Editorial Board of multiple kidney and transplantation journals.

Research Interests

Dr. Helderman has been very involved in the basic investigation into the regulation and description of lymphocyte activation pathways with particular reference to growth factor and cytokine receptors on T-lymphocytes. Using the model of the nonconstitutive activation marker, the insulin receptor, Dr. Helderman has developed an understanding of antigen-driven activation signals for the synthesis of new immunomodulatory molecules. His laboratory has discovered a monokine which regulates early lymphocyte activation cytokine and growth factor genes called Monocyte Receptor Regulatory Factor (MRRF) and has purified this substance to homogeneity and sequenced it. More recently the research interests of Dr. Helderman have been involved in the clinical research arena studying several new immunosuppressive drugs including Deoxyspergualin, Neoral Cyclosporine, Sirolimus (Rapamycin), and polyclonal rabbit anti-thymocyte globulin. A recent NIH trial of steroid withdrawal in Mycophenolate treated renal transplant patients has been initiated by Dr. Helderman. Chronic rejection its pathogenesis and management is a major research interest of Dr. Helderman. A 5-year NIH funded multicenter trial on this topic has begun this year.
Research Keywords
Growth factor and cytokine receptors on T lymphocytes
Giannico GA, Arnold S, Langone A, Schaefer H, Helderman JH, Shaffer D, Fogo AB. Non-immunoglobulin A mesangial immune complex glomerulonephritis in kidney transplants. Hum. Pathol [print-electronic]. 2015 Oct; 46(10): 1521-8. PMID: 26245687, PII: S0046-8177(15)00217-8, DOI: 10.1016/j.humpath.2015.06.012, ISSN: 1532-8392.

Ahmed F, Helderman JH, Langone A, Schaefer H. Persistent shortness of breath in a kidney transplant recipient. Am. J. Transplant. 2014 Apr; 14(4): 974-6. PMID: 24666834, DOI: 10.1111/ajt.12537, ISSN: 1600-6143.

Langone AJ, Helderman JH. Mammalian target of rapamycin inhibitors in organ transplantation: an unkept promise. Chest. 2012 Sep; 142(3): 734-7. PMID: 22948577, PII: 1356638, DOI: 10.1378/chest.12-1247, ISSN: 1931-3543.

Kasiske BL, Israni AK, Snyder JJ, Camarena A, . Design considerations and feasibility for a clinical trial to examine coronary screening before kidney transplantation (COST). Am. J. Kidney Dis [print-electronic]. 2011 Jun; 57(6): 908-16. PMID: 21411203, PMCID: PMC3587732, PII: S0272-6386(11)00132-6, DOI: 10.1053/j.ajkd.2011.01.020, ISSN: 1523-6838.

Schaefer HM, Langone A, Helderman JH, Fogo AB. Recurrent pauci-immune necrotizing crescentic glomerulonephritis in a kidney transplant patient. Am. J. Kidney Dis [print-electronic]. 2010 Mar; 55(3): 604-8. PMID: 19782451, PII: S0272-6386(09)01074-9, DOI: 10.1053/j.ajkd.2009.07.019, ISSN: 1523-6838.

Schaefer HM, Helderman JH. Allograft nephrectomy after transplant failure: should it be performed in all patients returning to dialysis? [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2010 Feb; 21(2): 207-8. PMID: 20075065, PII: ASN.2009121262, DOI: 10.1681/ASN.2009121262, ISSN: 1533-3450.

Helderman JH, Kang N, Legorreta AP, Chen JY. Healthcare costs in renal transplant recipients using branded versus generic ciclosporin. Appl Health Econ Health Policy. 2010; 8(1): 61-8. PMID: 20038194, PII: 6, DOI: 10.2165/11530720-000000000-00000, ISSN: 1175-5652.

Schaefer HM, Helderman JH. Contemporary dialysis: as good as transplantation?. Nature reviews. Nephrology. 2010 Jan; 6(1) Sect. 8,9.

Giullian JA, Helderman JH. Do calcium channel blockers prevent delayed graft function after renal transplantation?. Nat Clin Pract Nephrol [print-electronic]. 2008 Apr; 4(4): 192-3. PMID: 18227820, PII: ncpneph0742, DOI: 10.1038/ncpneph0742, ISSN: 1745-8331.

Gilmore AS, Helderman JH, Ricci JF, Ryskina KL, Feng S, Kang N, Legorreta AP. Linking the US transplant registry to administrative claims data: expanding the potential of transplant research. Med Care. 2007 Jun; 45(6): 529-36. PMID: 17515780, PII: 00005650-200706000-00008, DOI: 10.1097/MLR.0b013e3180326121, ISSN: 0025-7079.

Schaefer HM, Kizilisik AT, Feurer I, Nylander WA, Langone AJ, Helderman JH, Shaffer D. Short-term results under three different immunosuppressive regimens at one center. Transplant. Proc. 2006 Dec; 38(10): 3466-7. PMID: 17175305, PII: S0041-1345(06)01327-3, DOI: 10.1016/j.transproceed.2006.10.098, ISSN: 0041-1345.

Shaffer D, Kizilisik AT, Feurer I, Nylander WA, Helderman JH, Langone AJ, Schaefer HM. Calcineurin inhibitor avoidance versus steroid avoidance following kidney transplantation: Postoperative complications. Transplant. Proc. 2006 Dec; 38(10): 3464-5. PMID: 17175304, PII: S0041-1345(06)01332-7, DOI: 10.1016/j.transproceed.2006.10.103, ISSN: 0041-1345.

Schaefer HM, Helderman JH, Fogo AB. Slow decline in allograft function in a renal transplant patient. Am. J. Kidney Dis. 2006 Aug; 48(2): 335-8. PMID: 16860203, PII: S0272-6386(06)00943-7, DOI: 10.1053/j.ajkd.2006.02.193, ISSN: 1523-6838.

Schaefer HM, Kaplan B, Helderman JH. Mortality after kidney transplantation: what lessons can we learn from regional and country variation? [editorial]. Am. J. Transplant. 2006 Jan; 6(1): 3-4. PMID: 16433747, PII: AJT1196, DOI: 10.1111/j.1600-6143.2005.01196.x, ISSN: 1600-6135.

Revelo MP, Federspiel C, Helderman H, Fogo AB. Chronic allograft nephropathy: expression and localization of PAI-1 and PPAR-gamma. Nephrol. Dial. Transplant [print-electronic]. 2005 Dec; 20(12): 2812-9. PMID: 16221712, PII: gfi172, DOI: 10.1093/ndt/gfi172, ISSN: 0931-0509.

Tanriover B, Chuang P, Fishbach B, Helderman JH, Kizilisik T, Nylander W, Shaffer D, Langone AJ. Polyclonal antibody-induced serum sickness in renal transplant recipients: treatment with therapeutic plasma exchange. Transplantation. 2005 Jul 7/27/2005; 80(2): 279-81. PMID: 16041276, PII: 00007890-200507270-00019, ISSN: 0041-1337.

Ramanathan V, Goral S, Tanriover B, Feurer ID, Kazancioglu R, Shaffer D, Helderman JH. Screening asymptomatic diabetic patients for coronary artery disease prior to renal transplantation. Transplantation. 2005 May 5/27/2005; 79(10): 1453-8. PMID: 15912119, PII: 00007890-200505270-00032, ISSN: 0041-1337.

Kizilisik AT, Ray JB, Nylander WA, Langone AJ, Helderman JH, Shaffer D. Kidney transplantation in a veterans administration medical center: 40 years' experience. Exp Clin Transplant. 2004 Dec; 2(2): 238-41. PMID: 15859934, ISSN: 1304-0855.

Kizilisik AT, Ray JM, Nylander WA, Langone AJ, Helderman JH, Shaffer D. Living donor kidney transplantation in a Veterans Administration medical center. Am. J. Surg. 2004 Nov; 188(5): 611-3. PMID: 15546581, PII: S0002-9610(04)00355-1, DOI: 10.1016/j.amjsurg.2004.07.022, ISSN: 0002-9610.

Halloran PF, Langone AJ, Helderman JH, Kaplan B. Assessing long-term nephron loss: is it time to kick the CAN grading system? [editorial]. Am. J. Transplant. 2004 Nov; 4(11): 1729-30. PMID: 15476465, PII: AJT662, DOI: 10.1111/j.1600-6143.2004.00662.x, ISSN: 1600-6135.

Johnston A, Belitsky P, Frei U, Horvath J, Hoyer P, Helderman JH, Oellerich M, Pollard S, Riad H, Rigotti P, Keown P, Nashan B. Potential clinical implications of substitution of generic cyclosporine formulations for cyclosporine microemulsion (Neoral) in transplant recipients. Eur. J. Clin. Pharmacol [print-electronic]. 2004 Aug; 60(6): 389-95. PMID: 15205865, DOI: 10.1007/s00228-004-0774-8, ISSN: 0031-6970.

Langone AJ, Helderman JH. Experience with cyclosporine. Transplant. Proc. 2004 Mar; 36(2 Suppl): 59S-63S. PMID: 15041308, PII: S0041134504000739, DOI: 10.1016/j.transproceed.2004.01.022, ISSN: 0041-1345.

Kizilisik AT, Feurer ID, VanBuren DH, Wise P, Van Buren D, Hopkins J, Ray J, Nylander W, Shaffer D, Helderman JH, Langone AJ, Speroff T, Pinson CW. Effects of diabetes and cadaveric organs on functional performance and health-related quality of life after kidney transplantation. Am. J. Surg. 2003 Nov; 186(5): 535-9. PMID: 14599621, PII: S0002961003003362, ISSN: 0002-9610.

Shaffer D, Langone A, Nylander WA, Goral S, Kizilisik AT, Helderman JH. A pilot protocol of a calcineurin-inhibitor free regimen for kidney transplant recipients of marginal donor kidneys or with delayed graft function. Clin Transplant. 2003; 17 Suppl 9: 31-4. PMID: 12795665, PII: 85, ISSN: 0902-0063.

Helderman JH, Bennett WM, Cibrik DM, Kaufman DB, Klein A, Takemoto SK. Immunosuppression: practice and trends. Am. J. Transplant. 2003; 3 Suppl 4: 41-52. PMID: 12694049, PII: 099, ISSN: 1600-6135.

Geiger X, Chang I, Goral S, Helderman JH, Fogo A. A 50-year-old man with persistent renal allograft dysfunction. Am. J. Kidney Dis. 2002 Jul; 40(1): 210-7. PMID: 12087583, PII: S0272-6386(02)00029-X, DOI: 10.1053/ajkd.2002.34383, ISSN: 1523-6838.

Kazancioglu R, Goral S, Shockley SL, Feurer ID, Ramanathan V, Helderman JH, VanBuren D. A systematic examination of estimates of cyclosporine area under the curve in renal transplant recipients. Transplantation. 2002 Jan 1/27/2002; 73(2): 301-2. PMID: 11821749, ISSN: 0041-1337.

Helderman JH, Goral S. Gastrointestinal complications of transplant immunosuppression. J. Am. Soc. Nephrol. 2002 Jan; 13(1): 277-87. PMID: 11752050, ISSN: 1046-6673.

Helderman JH. General considerations of immunosuppressive therapies--efficacy versus toxicity. Transplant. Proc. 2001 May; 33(3A Suppl): 2S-3S. PMID: 11376794, PII: S0041134501020620, ISSN: 0041-1345.

Helderman JH. Prophylaxis and treatment of gastrointestinal complications following transplantation. Clin Transplant. 2001; 15 Suppl 4: 29-35. PMID: 11778785, ISSN: 0902-0063.

Goral, S. and Helderman, J.H. Renal transplantation: approaches to graft dysfunction and the consequences of immunosuppression. 1997.

Helderman, J.H. and Goral, S. Transplantation immunobiology. 1996.

Helderman, J.H. and Goral, S. Update in transplantation 1995. Clinical Transplants 1995, Cecka and Terasaki, Eds. UCLA Tissue Typing Laboratory. (UCLA Press). 1996; 323-50.

Helderman, J.H., Van Buren, D.H., Amend, J.C., Jr., and Pirsch, J.D. Chronic immunosuppression of the renal transplant patient. 1994.

Helderman, J.H. Principles and practices of renal transplant rejection. 1994.

Mellema J, Holterman HJ, Waterman HA, Blom C, Gravenmade EJ. Rheological aspects of mucin-containing solutions and saliva substitutes. Biorheology. 1992 Mar; 29(2-3): 231-49. PMID: 1298442, ISSN: 0006-355X.

Lipman, M.L., Stevens, A.C., Bleackley, R.C., Helderman, J.H., et al. The strong correlation of cytotoxic T lymphocyte-specific serine protease gene transcripts with renal allograft rejection. 1992.

Helderman, J.H., Womble, D., Ghandour, E., and Womble, S. Identification of a nonocyte-derived factor which regulates synthesis of insulin receptors on activated T-lymphocytes (MIRRF). 1992.

Koffler, M., Raskin, P., Womble, D., and Helderman, J.H. Immunobiological consequence of regulation of insulin receptor on alloactivated lymphocytes in normal and obese subjects. 1991.

Helderman, J.H., et al. Confirmation of the utility of fine needle aspiration biopsy of the renal allograft. 1988.

Waterman HA, Blom C, Holterman HJ, 's-Gravenmade EJ, Mellema J. Rheological properties of human saliva. Arch. Oral Biol. 1988; 33(8): 589-96. PMID: 3254128, ISSN: 0003-9969.

Helderman, J.H., Ayuso, R., Rosenstock, J., and Raskin, P. Monocyte-T lymphocyte interaction for regulation of insulin receptors on the activated T lymphocyte. 1987.