Joseph A. Awad, M.D.

Faculty Appointments
Professor of Medicine
M.D., Medicine, Washington University, Saint Louis, MissouriB.A., Molecular Biology , Vanderbilt University, Nashville, Tennessee
Office Address
2E121G, VA Transplant Center (11T)
1310 24th Avenue South
Nashville, TN 37212-2637
Awad J, Owrangi A, Villemaire L, O'Riordan E, Parraga G, Fenster A. Three-dimensional lung tumor segmentation from x-ray computed tomography using sparse field active models. Med Phys. 2012 Feb; 39(2): 851-65. PMID: 22320795, DOI: 10.1118/1.3676687, ISSN: 0094-2405.

Awad J, Krasinski A, Parraga G, Fenster A. Texture analysis of carotid artery atherosclerosis from three-dimensional ultrasound images. Med Phys. 2010 Apr; 37(4): 1382-91. PMID: 20443459, DOI: 10.1118/1.3301592, ISSN: 0094-2405.

Bini EJ, Bräu N, Currie S, Shen H, Anand BS, Hu KQ, Jeffers L, Ho SB, Johnson D, Schmidt WN, King P, Cheung R, Morgan TR, Awad J, Pedrosa M, Chang KM, Aytaman A, Simon F, Hagedorn C, Moseley R, Ahmad J, Mendenhall C, Waters B, Strader D, Sasaki AW, Rossi S, Wright TL. Prospective multicenter study of eligibility for antiviral therapy among 4,084 U.S. veterans with chronic hepatitis C virus infection. Am. J. Gastroenterol. 2005 Aug; 100(8): 1772-9. PMID: 16086714, PII: AJG41860, DOI: 10.1111/j.1572-0241.2005.41860.x, ISSN: 0002-9270.

Fussell KM, Awad JA, Ware LB. Case of fulminant hepatic failure due to unrecognized peripartum cardiomyopathy. Crit. Care Med. 2005 Apr; 33(4): 891-3. PMID: 15818120, PII: 00003246-200504000-00029, ISSN: 0090-3493.

Roumie CL, Grogan EL, Falbe W, Awad J, Speroff T, Dittus RS, Elasy TA. A three-part intervention to change the use of hormone replacement therapy in response to new evidence. Ann. Intern. Med. 2004 Jul 7/20/2004; 141(2): 118-25. PMID: 15262667, PII: 141/2/118, ISSN: 1539-3704.

Moore D, Feurer I, Speroff T, Shaffer D, Nylander W, Kizilisik T, Butler J, Awad J, Gorden DL, Chari R, Wright JK, Pinson CW. Survival and quality of life after organ transplantation in veterans and nonveterans. Am. J. Surg. 2003 Nov; 186(5): 476-80. PMID: 14599610, PII: S0002961003003532, ISSN: 0002-9610.

Kauffman LD, Sokol RJ, Jones RH, Awad JA, Rewers MJ, Norris JM. Urinary F2-isoprostanes in young healthy children at risk for type 1 diabetes mellitus. Free Radic. Biol. Med. 2003 Sep 9/15/2003; 35(6): 551-7. PMID: 12957647, PII: S0891584903003332, ISSN: 0891-5849.

Rosenbloom ST, Awad J, Speroff T, Elkin PL, Rothman R, Spickard A, Peterson J, Bauer BA, Wahner-Roedler DL, Lee M, Gregg WM, Johnson KB, Jirjis J, Erlbaum MS, Carter JS, Lincoln MJ, Brown SH. Adequacy of representation of the National Drug File Reference Terminology Physiologic Effects reference hierarchy for commonly prescribed medications. AMIA Annu Symp Proc. 2003; 569-78. PMID: 14728237, PMCID: PMC1480331, PII: D030003134, ISSN: 1942-597X.

Seifert JA, Ross CA, Deutsch JC, Awad JA, Norris JM. Validating methods of urine collection: a pilot study. Urol Nurs. 2002 Apr; 22(2): 113-7. PMID: 11993239, ISSN: 1053-816X.

Hunter EB, Johnston PE, Tanner G, Pinson CW, Awad JA. Bromfenac (Duract)-associated hepatic failure requiring liver transplantation. Am. J. Gastroenterol. 1999 Aug; 94(8): 2299-301. PMID: 10445569, PII: S0002927099003779, DOI: 10.1111/j.1572-0241.1999.01321.x, ISSN: 0002-9270.

Hill DB, Awad JA. Increased urinary F2-isoprostane excretion in alcoholic liver disease. Free Radic. Biol. Med. 1999 Mar; 26(5-6): 656-60. PMID: 10218654, PII: S0891-5849(98)00250-0, ISSN: 0891-5849.

Morrow JD, Chen Y, Brame CJ, Yang J, Sanchez SC, Xu J, Zackert WE, Awad JA, Roberts LJ. The isoprostanes: unique prostaglandin-like products of free-radical-initiated lipid peroxidation. Drug Metab. Rev. 1999 Feb; 31(1): 117-39. PMID: 10065368, DOI: 10.1081/DMR-100101910, ISSN: 0360-2532.

Kadiiska MB, Morrow JD, Awad JA, Roberts LJ, Mason RP. Identification of free radical formation and F2-isoprostanes in vivo by acute Cr(VI) poisoning. Chem. Res. Toxicol. 1998 Dec; 11(12): 1516-20. PMID: 9860496, PII: tx980169e, DOI: 10.1021/tx980169e, ISSN: 0893-228X.

Morrow JD, Roberts LJ, Daniel VC, Awad JA, Mirochnitchenko O, Swift LL, Burk RF. Comparison of formation of D2/E2-isoprostanes and F2-isoprostanes in vitro and in vivo--effects of oxygen tension and glutathione. Arch. Biochem. Biophys. 1998 May 5/1/1998; 353(1): 160-71. PMID: 9578611, PII: S0003-9861(98)90645-2, DOI: 10.1006/abbi.1998.0645, ISSN: 0003-9861.

Pinson CW, Chapman WC, Wright JK, Hunter EB, Awad JA, Raiford DS, Payne JL, Geevarghese S, Blair TK, Van Buren DH. Experience with neoral versus sandimmune in primary liver transplant recipients. Transpl. Int. 1998; 11 Suppl 1: S278-83. PMID: 9664997, ISSN: 0934-0874.

Chapman WC, Wright JK, Awad JA, Hunter EB, Raiford DS, Blair TK, Pinson CW. Nashville experience with liver transplantation in Veterans Administration patients. J. Surg. Res. 1997 Jan; 67(1): 79-83. PMID: 9070186, PII: S0022-4804(96)94969-0, DOI: 10.1006/jsre.1996.4969, ISSN: 0022-4804.

Morrow JD, Awad JA, Wu A, Zackert WE, Daniel VC, Roberts LJ. Nonenzymatic free radical-catalyzed generation of thromboxane-like compounds (isothromboxanes) in vivo. J. Biol. Chem. 1996 Sep 9/20/1996; 271(38): 23185-90. PMID: 8798513, ISSN: 0021-9258.

Stein CM, Tanner SB, Awad JA, Roberts LJ, Morrow JD. Evidence of free radical-mediated injury (isoprostane overproduction) in scleroderma. Arthritis Rheum. 1996 Jul; 39(7): 1146-50. PMID: 8670323, ISSN: 0004-3591.

Awad JA, Roberts LJ, Burk RF, Morrow JD. Isoprostanes--prostaglandin-like compounds formed in vivo independently of cyclooxygenase: use as clinical indicators of oxidant damage. Gastroenterol. Clin. North Am. 1996 Jun; 25(2): 409-27. PMID: 9229581, ISSN: 0889-8553.

Awad JA, Horn JL, Roberts LJ, Franks JJ. Demonstration of halothane-induced hepatic lipid peroxidation in rats by quantification of F2-isoprostanes. Anesthesiology. 1996 Apr; 84(4): 910-6. PMID: 8638846, ISSN: 0003-3022.

Payne JL, McCarty KR, Drougas JG, Chapman WC, Wright JK, Pinson NY, Beliles KE, Newsom VL, Hunter EB, Raiford DS, Awad JA, Burk RF, Donovan KL, Van Buren DH, Pinson CW. Outcomes analysis for 50 liver transplant recipients: the Vanderbilt experience. Am Surg. 1996 Apr; 62(4): 320-5. PMID: 8600857, ISSN: 0003-1348.

Awad JA, Morrow JD. Excretion of F2-isoprostanes in bile: a novel index of hepatic lipid peroxidation. Hepatology. 1995 Sep; 22(3): 962-8. PMID: 7657304, PII: 0270-9139(95)90321-6, ISSN: 0270-9139.

Burk RF, Hill KE, Awad JA, Morrow JD, Lyons PR. Liver and kidney necrosis in selenium-deficient rats depleted of glutathione. Lab. Invest. 1995 Jun; 72(6): 723-30. PMID: 7783430, ISSN: 0023-6837.

Adeniran AJ, Shoshani I, Minuth M, Awad JA, Elce JS, Johnson RA. Purification, characterization, and N-terminal amino acid sequence of the adenylyl cyclase-activating protease from bovine sperm. Biol. Reprod. 1995 Mar; 52(3): 490-9. PMID: 7756444, ISSN: 0006-3363.

Burk RF, Hill KE, Awad JA, Morrow JD, Kato T, Cockell KA, Lyons PR. Pathogenesis of diquat-induced liver necrosis in selenium-deficient rats: assessment of the roles of lipid peroxidation and selenoprotein P. Hepatology. 1995 Feb; 21(2): 561-9. PMID: 7843731, PII: S0270913995000760, ISSN: 0270-9139.

Morrow JD, Minton TA, Awad JA, Roberts LJ. Release of markedly increased quantities of prostaglandin D2 from the skin in vivo in humans following the application of sorbic acid. Arch Dermatol. 1994 Nov; 130(11): 1408-12. PMID: 7979442, ISSN: 0003-987X.

Awad JA, Burk RF, Roberts LJ. Effect of selenium deficiency and glutathione-modulating agents on diquat toxicity and lipid peroxidation in rats. J. Pharmacol. Exp. Ther. 1994 Sep; 270(3): 858-64. PMID: 7932197, ISSN: 0022-3565.

Awad JA, Morrow JD, Hill KE, Roberts LJ, Burk RF. Detection and localization of lipid peroxidation in selenium- and vitamin E-deficient rats using F2-isoprostanes. J. Nutr. 1994 Jun; 124(6): 810-6. PMID: 8207538, ISSN: 0022-3166.

DuBois RN, Tsujii M, Bishop P, Awad JA, Makita K, Lanahan A. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. Am. J. Physiol. 1994 May; 266(5 Pt 1): G822-7. PMID: 8203528, ISSN: 0002-9513.

Awad JA, Morrow JD, Roberts LJ. Detection of the major urinary metabolite of prostaglandin D2 in the circulation: demonstration of elevated levels in patients with disorders of systemic mast cell activation. J. Allergy Clin. Immunol. 1994 May; 93(5): 817-24. PMID: 8182221, PII: 0091-6749(94)90371-9, ISSN: 0091-6749.

Longmire AW, Swift LL, Roberts LJ, Awad JA, Burk RF, Morrow JD. Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem. Pharmacol. 1994 Mar 3/29/1994; 47(7): 1173-7. PMID: 8161346, ISSN: 0006-2952.

Drougas JG, Hunter EB, Raiford DS, Burk RF, Awad JA, Wright JK, Lopez RR, Donovan KL, Franks JJ, Thomas AT. Liver transplantation: results with Vanderbilt's first 25 liver recipients. J Tenn Med Assoc. 1994 Jan; 87(1): 7-10. PMID: 8145559, ISSN: 0040-3318.

Beno DW, Awad JA, Davis BH. Gamma-linolenic acid suppression of hepatic Ito cell mitogenesis: post-PDGF receptor prostaglandin-independent mechanism. Am. J. Physiol. 1993 Nov; 265(5 Pt 1): C1388-95. PMID: 7694498, ISSN: 0002-9513.

Awad JA, Morrow JD, Roberts LJ. Simplification of the mass spectrometric assay for the major urinary metabolite of prostaglandin D2. J. Chromatogr. 1993 Jul 7/23/1993; 617(1): 124-8. PMID: 8376525.

Morrow JD, Moore KP, Awad JA, Ravenscraft MD, Marini G, Badr KF, Williams R, Roberts LJ. Marked overproduction of non-cyclooxygenase derived prostanoids (F2-isoprostanes) in the hepatorenal syndrome. J Lipid Mediat. 1993 Mar; 6(1-3): 417-20. PMID: 8358000, ISSN: 0921-8319.

Awad JA, Morrow JD, Takahashi K, Roberts LJ. Identification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma. J. Biol. Chem. 1993 Feb 2/25/1993; 268(6): 4161-9. PMID: 8440704, ISSN: 0021-9258.

Morrow JD, Awad JA, Kato T, Takahashi K, Badr KF, Roberts LJ, Burk RF. Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation. J. Clin. Invest. 1992 Dec; 90(6): 2502-7. PMID: 1469101, PMCID: PMC443408, DOI: 10.1172/JCI116143, ISSN: 0021-9738.

Romano M, Polk WH, Awad JA, Arteaga CL, Nanney LB, Wargovich MJ, Kraus ER, Boland CR, Coffey RJ. Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo. J. Clin. Invest. 1992 Dec; 90(6): 2409-21. PMID: 1281834, PMCID: PMC443397, DOI: 10.1172/JCI116132, ISSN: 0021-9738.

Morrow JD, Awad JA, Boss HJ, Blair IA, Roberts LJ. Non-cyclooxygenase-derived prostanoids (F2-isoprostanes) are formed in situ on phospholipids. Proc. Natl. Acad. Sci. U.S.A. 1992 Nov 11/15/1992; 89(22): 10721-5. PMID: 1438268, PMCID: PMC50413, ISSN: 0027-8424.

Morrow JD, Awad JA, Oates JA, Roberts LJ. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J. Invest. Dermatol. 1992 May; 98(5): 812-5. PMID: 1373750, ISSN: 0022-202X.

Morrow JD, Prakash C, Awad JA, Duckworth TA, Zackert WE, Blair IA, Oates JA, Roberts LJ. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 1991 Feb 2/15/1991; 193(1): 142-8. PMID: 2042739, ISSN: 0003-2697.

Awad JA, Lee EY, Wang TC, Deschryver-Kecskemeti K, Clouse RE. Effect of mucosal thickening near gastric carcinoma on the endoscopic diagnosis of malignancy. Dig. Dis. Sci. 1990 Mar; 35(3): 317-20. PMID: 2307077, ISSN: 0163-2116.

Awad JA, Johnson RA, Jakobs KH, Schultz G. Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide. J. Biol. Chem. 1983 Mar 3/10/1983; 258(5): 2960-5. PMID: 6681815, ISSN: 0021-9258.

Johnson RA, Awad JA, Jakobs KH, Schultz G. Activation of brain adenylate cyclase by a factor derived from bovine sperm. FEBS Lett. 1983 Feb 2/7/1983; 152(1): 11-6. PMID: 6404648, PII: 0014-5793(83)80471-2, ISSN: 0014-5793.