Lan Wu, M.D.

Research Associate Professor

lan.wu.1@vanderbilt.edu
Faculty Appointments
Research Associate Professor of Pathology, Microbiology and Immunology
Education
M.S., Molecular Endocrinology, Tongji University, Shanghai, ChinaM.D., Tongji University, Shanghai, China
Office Address
811 Light Hall
TN 0295
Publications
Wu L, Gabriel CL, Parekh VV, Van Kaer L. Invariant natural killer T cells: innate-like T cells with potent immunomodulatory activities. Tissue Antigens [print-electronic]. 2009 Jun; 73(6): 535-45. PMID: 19392798, PII: TAN1256, DOI: 10.1111/j.1399-0039.2009.01256.x, ISSN: 1399-0039.

Parekh VV, Lalani S, Kim S, Halder R, Azuma M, Yagita H, Kumar V, Wu L, Kaer LV. PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J. Immunol. 2009 Mar 3/1/2009; 182(5): 2816-26. PMID: 19234176, PMCID: PMC2709814, PII: 182/5/2816, DOI: 10.4049/jimmunol.0803648, ISSN: 1550-6606.

Wu L, Van Kaer L. Natural killer T cells and autoimmune disease. Curr. Mol. Med. 2009 Feb; 9(1): 4-14. PMID: 19199937, ISSN: 1566-5240.

Kim S, Lalani S, Parekh VV, Wu L, Van Kaer L. Glycolipid ligands of invariant natural killer T cells as vaccine adjuvants. Expert Rev Vaccines. 2008 Dec; 7(10): 1519-32. PMID: 19053208, PMCID: PMC2680388, DOI: 10.1586/14760584.7.10.1519, ISSN: 1744-8395.

Kim S, Lalani S, Parekh VV, Vincent TL, Wu L, Van Kaer L. Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice. J. Clin. Invest. 2008 Jun; 118(6): 2301-15. PMID: 18451996, PMCID: PMC2350429, DOI: 10.1172/JCI33071, ISSN: 0021-9738.

Wu L, Van Kaer L. Role of NKT cells in the digestive system. II. NKT cells and diabetes. Am. J. Physiol. Gastrointest. Liver Physiol [print-electronic]. 2007 Nov; 293(5): G919-22. PMID: 17600041, PII: 00242.2007, DOI: 10.1152/ajpgi.00242.2007, ISSN: 0193-1857.

Parekh VV, Wilson MT, Olivares-Villagómez D, Singh AK, Wu L, Wang CR, Joyce S, Van Kaer L. Glycolipid antigen induces long-term natural killer T cell anergy in mice. J. Clin. Invest. 2005 Sep; 115(9): 2572-83. PMID: 16138194, PMCID: PMC1193878, DOI: 10.1172/JCI24762, ISSN: 0021-9738.

Steffner RJ, Wu L, Powers AC, May JM. Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism. Free Radic. Biol. Med. 2004 Nov 11/15/2004; 37(10): 1612-21. PMID: 15477012, PII: S0891-5849(04)00608-2, DOI: 10.1016/j.freeradbiomed.2004.07.032, ISSN: 0891-5849.

Parekh VV, Singh AK, Wilson MT, Olivares-Villagómez D, Bezbradica JS, Inazawa H, Ehara H, Sakai T, Serizawa I, Wu L, Wang CR, Joyce S, Van Kaer L. Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids. J. Immunol. 2004 Sep 9/15/2004; 173(6): 3693-706. PMID: 15356115, PII: 173/6/3693, ISSN: 0022-1767.

Wu L, Nicholson W, Knobel SM, Steffner RJ, May JM, Piston DW, Powers AC. Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines. J. Biol. Chem [print-electronic]. 2004 Mar 3/26/2004; 279(13): 12126-34. PMID: 14688272, PII: M307097200, DOI: 10.1074/jbc.M307097200, ISSN: 0021-9258.

Wu L, Nicholson W, Wu CY, Xu M, McGaha A, Shiota M, Powers AC. Engineering physiologically regulated insulin secretion in non-beta cells by expressing glucagon-like peptide 1 receptor. Gene Ther. 2003 Sep; 10(19): 1712-20. PMID: 12923570, PII: 3302055, DOI: 10.1038/sj.gt.3302055, ISSN: 0969-7128.

Hong S, Wilson MT, Serizawa I, Wu L, Singh N, Naidenko OV, Miura T, Haba T, Scherer DC, Wei J, Kronenberg M, Koezuka Y, Van Kaer L. The natural killer T-cell ligand alpha-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 2001 Sep; 7(9): 1052-6. PMID: 11533710, PII: nm0901-1052, DOI: 10.1038/nm0901-1052, ISSN: 1078-8956.

Wu L, Fritz JD, Powers AC. Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity. Endocrinology. 1998 Oct; 139(10): 4205-12. PMID: 9751501, DOI: 10.1210/endo.139.10.6245, ISSN: 0013-7227.

Fritz JD, Utz AL, Hale NM, Wu L, Powers AC, Verdoorn TA, Robertson D. Gene-based neurotransmitter modulation in cerebellar granule neurons. J. Neurochem. 1997 Jan; 68(1): 204-12. PMID: 8978727, ISSN: 0022-3042.

Buchs A, Wu L, Morita H, Whitesell RR, Powers AC. Two regions of GLUT 2 glucose transporter protein are responsible for its distinctive affinity for glucose. Endocrinology. 1995 Oct; 136(10): 4224-30. PMID: 7664639, DOI: 10.1210/endo.136.10.7664639, ISSN: 0013-7227.

Morita H, Yano Y, Niswender KD, May JM, Whitesell RR, Wu L, Printz RL, Granner DK, Magnuson MA, Powers AC. Coexpression of glucose transporters and glucokinase in Xenopus oocytes indicates that both glucose transport and phosphorylation determine glucose utilization. J. Clin. Invest. 1994 Oct; 94(4): 1373-82. PMID: 7929812, PMCID: PMC295259, DOI: 10.1172/JCI117472, ISSN: 0021-9738.