Robert T. Matthews, Ph.D.

Research Associate Professor

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Faculty Appointments
Research Associate Professor of Molecular Physiology and Biophysics
Ph.D., Pharmacology, University of Florida, Gainesville, FloridaB.S., Biology, Ursinus College, Collegeville, Pennsylvania
Office Address
724 RRB
702 Light Hall
2220 Pierce Ave
Nashville, TN 37232-0615
Massey JM, Amps J, Viapiano MS, Matthews RT, Wagoner MR, Whitaker CM, Alilain W, Yonkof AL, Khalyfa A, Cooper NG, Silver J, Onifer SM. Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. Exp. Neurol [print-electronic]. 2008 Feb; 209(2): 426-45. PMID: 17540369, PMCID: PMC2270474, PII: S0014-4886(07)00136-7, DOI: 10.1016/j.expneurol.2007.03.029, ISSN: 0014-4886.

McRae PA, Rocco MM, Kelly G, Brumberg JC, Matthews RT. Sensory deprivation alters aggrecan and perineuronal net expression in the mouse barrel cortex. J. Neurosci. 2007 May 5/16/2007; 27(20): 5405-13. PMID: 17507562, PII: 27/20/5405, DOI: 10.1523/JNEUROSCI.5425-06.2007, ISSN: 1529-2401.

Gu Z, Zitzewitz JA, Matthews CR. Mapping the structure of folding cores in TIM barrel proteins by hydrogen exchange mass spectrometry: the roles of motif and sequence for the indole-3-glycerol phosphate synthase from Sulfolobus solfataricus. J. Mol. Biol [print-electronic]. 2007 Apr 4/27/2007; 368(2): 582-94. PMID: 17359995, PMCID: PMC2040069, PII: S0022-2836(07)00208-2, DOI: 10.1016/j.jmb.2007.02.027, ISSN: 0022-2836.

Arai M, Kondrashkina E, Kayatekin C, Matthews CR, Iwakura M, Bilsel O. Microsecond hydrophobic collapse in the folding of Escherichia coli dihydrofolate reductase, an alpha/beta-type protein. J. Mol. Biol [print-electronic]. 2007 Apr 4/20/2007; 368(1): 219-29. PMID: 17331539, PII: S0022-2836(07)00163-5, DOI: 10.1016/j.jmb.2007.01.085, ISSN: 0022-2836.

Cheng H, Sathiakumar N, Graff J, Matthews R, Delzell E. 1,3-Butadiene and leukemia among synthetic rubber industry workers: exposure-response relationships. Chem. Biol. Interact [print-electronic]. 2007 Mar 3/20/2007; 166(1-3): 15-24. PMID: 17123495, PII: S0009-2797(06)00290-0, DOI: 10.1016/j.cbi.2006.10.004, ISSN: 0009-2797.

Wu Y, Vadrevu R, Kathuria S, Yang X, Matthews CR. A tightly packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein. J. Mol. Biol [print-electronic]. 2007 Mar 3/9/2007; 366(5): 1624-38. PMID: 17222865, PMCID: PMC1894912, PII: S0022-2836(06)01664-0, DOI: 10.1016/j.jmb.2006.12.005, ISSN: 0022-2836.

Svensson AK, Bilsel O, Kondrashkina E, Zitzewitz JA, Matthews CR. Mapping the folding free energy surface for metal-free human Cu,Zn superoxide dismutase. J. Mol. Biol [print-electronic]. 2006 Dec 12/15/2006; 364(5): 1084-102. PMID: 17046019, PII: S0022-2836(06)01177-6, DOI: 10.1016/j.jmb.2006.09.005, ISSN: 0022-2836.

Matthews R, Franceschi D, Xia W, Cabahug C, Schuman G, Bernstein R, Peyster R. Parietal lobe epileptic focus identified on SPECT-MRI fusion imaging in a case of epilepsia partialis continua. Clin Nucl Med. 2006 Dec; 31(12): 826-8. PMID: 17117087, PII: 00003072-200612000-00023, DOI: 10.1097/, ISSN: 0363-9762.

Dino MR, Harroch S, Hockfield S, Matthews RT. Monoclonal antibody Cat-315 detects a glycoform of receptor protein tyrosine phosphatase beta/phosphacan early in CNS development that localizes to extrasynaptic sites prior to synapse formation. Neuroscience [print-electronic]. 2006 Nov 11/3/2006; 142(4): 1055-69. PMID: 16989954, PII: S0306-4522(06)00984-5, DOI: 10.1016/j.neuroscience.2006.07.054, ISSN: 0306-4522.

Simler BR, Levy Y, Onuchic JN, Matthews CR. The folding energy landscape of the dimerization domain of Escherichia coli Trp repressor: a joint experimental and theoretical investigation. J. Mol. Biol [print-electronic]. 2006 Oct 10/13/2006; 363(1): 262-78. PMID: 16956620, PMCID: PMC1866298, PII: S0022-2836(06)00977-6, DOI: 10.1016/j.jmb.2006.07.080, ISSN: 0022-2836.

Viapiano MS, Matthews RT. From barriers to bridges: chondroitin sulfate proteoglycans in neuropathology. Trends Mol Med [print-electronic]. 2006 Oct; 12(10): 488-96. PMID: 16962376, PII: S1471-4914(06)00194-8, DOI: 10.1016/j.molmed.2006.08.007, ISSN: 1471-4914.

Matthews R. Profiling of CSF: reliability of diagnosis [letter]. PLoS Med. 2006 Oct; 3(10): e469; author reply e468. PMID: 17076579, PMCID: PMC1626570, PII: 06-PLME-C-0737, DOI: 10.1371/journal.pmed.0030469, ISSN: 1549-1676.

Delzell E, Sathiakumar N, Graff J, Macaluso M, Maldonado G, Matthews R, . An updated study of mortality among North American synthetic rubber industry workers. Res Rep Health Eff Inst. 2006 Aug; (132): 1-63; discussion 65. PMID: 17326338, ISSN: 1041-5505.

Matthews R. Isoproterenol-induced elevated bispectral indexes while undergoing radiofrequency ablation: a case report. AANA J. 2006 Jun; 74(3): 193-5. PMID: 16786912, ISSN: 0094-6354.

Svensson AK, Zitzewitz JA, Matthews CR, Smith VF. The relationship between chain connectivity and domain stability in the equilibrium and kinetic folding mechanisms of dihydrofolate reductase from E.coli. Protein Eng. Des. Sel [print-electronic]. 2006 Apr; 19(4): 175-85. PMID: 16452118, PII: gzj017, DOI: 10.1093/protein/gzj017, ISSN: 1741-0126.

Bender TJ, Beall C, Cheng H, Herrick RF, Kahn AR, Matthews R, Sathiakumar N, Schymura MJ, Stewart JH, Delzell E. Methodologic issues in follow-up studies of cancer incidence among occupational groups in the United States. Ann Epidemiol [print-electronic]. 2006 Mar; 16(3): 170-9. PMID: 16181790, PII: S1047-2797(05)00253-X, DOI: 10.1016/j.annepidem.2005.06.055, ISSN: 1047-2797.

Chalmers I, Matthews R. What are the implications of optimism bias in clinical research?. Lancet. 2006 Feb 2/11/2006; 367(9509): 449-50. PMID: 16473106, PII: S0140-6736(06)68153-1, DOI: 10.1016/S0140-6736(06)68153-1, ISSN: 1474-547X.

Bilsel O, Matthews CR. Molecular dimensions and their distributions in early folding intermediates. Curr. Opin. Struct. Biol [print-electronic]. 2006 Feb; 16(1): 86-93. PMID: 16442277, PII: S0959-440X(06)00009-1, DOI: 10.1016/, ISSN: 0959-440X.

Sloan KE, Stewart JK, Treloar AF, Matthews RT, Jay DG. CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics. Cancer Res. 2005 Dec 12/1/2005; 65(23): 10930-7. PMID: 16322240, PII: 65/23/10930, DOI: 10.1158/0008-5472.CAN-05-1890, ISSN: 0008-5472.

Delzell E, Sathiakumar N, Graff J, Matthews R. Styrene and ischemic heart disease mortality among synthetic rubber industry workers. J. Occup. Environ. Med. 2005 Dec; 47(12): 1235-43. PMID: 16340704, PII: 00043764-200512000-00008, ISSN: 1076-2752.

Beall C, Bender TJ, Cheng H, Herrick R, Kahn A, Matthews R, Sathiakumar N, Schymura M, Stewart J, Delzell E. Mortality among semiconductor and storage device-manufacturing workers. J. Occup. Environ. Med. 2005 Oct; 47(10): 996-1014. PMID: 16217241, PII: 00043764-200510000-00007, ISSN: 1076-2752.

Herrick RF, Stewart JH, Blicharz D, Beall C, Bender T, Cheng H, Matthews R, Sathiakumar N, Delzell E. Exposure assessment for retrospective follow-up studies of semiconductor- and storage device-manufacturing workers. J. Occup. Environ. Med. 2005 Oct; 47(10): 983-95. PMID: 16217240, PII: 00043764-200510000-00006, ISSN: 1076-2752.

Graff JJ, Sathiakumar N, Macaluso M, Maldonado G, Matthews R, Delzell E. Chemical exposures in the synthetic rubber industry and lymphohematopoietic cancer mortality. J. Occup. Environ. Med. 2005 Sep; 47(9): 916-32. PMID: 16155477, PII: 00043764-200509000-00007, ISSN: 1076-2752.

Wu Y, Vadrevu R, Yang X, Matthews CR. Specific structure appears at the N terminus in the sub-millisecond folding intermediate of the alpha subunit of tryptophan synthase, a TIM barrel protein. J. Mol. Biol. 2005 Aug 8/19/2005; 351(3): 445-52. PMID: 16023136, PII: S0022-2836(05)00655-8, DOI: 10.1016/j.jmb.2005.06.006, ISSN: 0022-2836.

Viapiano MS, Bi WL, Piepmeier J, Hockfield S, Matthews RT. Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas. Cancer Res. 2005 Aug 8/1/2005; 65(15): 6726-33. PMID: 16061654, PII: 65/15/6726, DOI: 10.1158/0008-5472.CAN-05-0585, ISSN: 0008-5472.

Matthews R. No way to treat a patient: tens of thousands of people have been subjected to unnecessary drug trials. New Sci. 2005 Jul 7/9/2005; 187(2507): 19. PMID: 16178106, ISSN: 0262-4079.

Matthews R, Franceschi D, Cabahug C. Abdominal muscle uptake on FDG PET secondary to multiple rib fractures and use of accessory muscles of respiration. Clin Nucl Med. 2005 May; 30(5): 333-4. PMID: 15827405, PII: 00003072-200505000-00011, ISSN: 0363-9762.

Wintrode PL, Rojsajjakul T, Vadrevu R, Matthews CR, Smith DL. An obligatory intermediate controls the folding of the alpha-subunit of tryptophan synthase, a TIM barrel protein. J. Mol. Biol. 2005 Apr 4/15/2005; 347(5): 911-9. PMID: 15784252, PII: S0022-2836(05)00122-1, DOI: 10.1016/j.jmb.2005.01.064, ISSN: 0022-2836.

Egli RE, Kash TL, Choo K, Savchenko V, Matthews RT, Blakely RD, Winder DG. Norepinephrine modulates glutamatergic transmission in the bed nucleus of the stria terminalis. Neuropsychopharmacology. 2005 Apr; 30(4): 657-68. PMID: 15602500, PII: 1300639, DOI: 10.1038/sj.npp.1300639, ISSN: 0893-133X.

Matthews R. A risk we have to swallow: can we ever be sure that medicines are safe before they hit the market?. New Sci. 2005 Mar 3/5/2005; 185(2489): 23. PMID: 15839012, ISSN: 0262-4079.

Andrews ZB, Horvath B, Barnstable CJ, Elsworth J, Yang L, Beal MF, Roth RH, Matthews RT, Horvath TL. Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J. Neurosci. 2005 Jan 1/5/2005; 25(1): 184-91. PMID: 15634780, PII: 25/1/184, DOI: 10.1523/JNEUROSCI.4269-04.2005, ISSN: 1529-2401.

Kelsey JE, Mague SD, Pijanowski RS, Harris RC, Kleckner NW, Matthews RT. NMDA receptor antagonists ameliorate the stepping deficits produced by unilateral medial forebrain bundle injections of 6-OHDA in rats. Psychopharmacology (Berl.) [print-electronic]. 2004 Sep; 175(2): 179-88. PMID: 15007533, DOI: 10.1007/s00213-004-1799-5, ISSN: 0033-3158.

Matthews RT, Coker O, Winder DG. A novel mouse brain slice preparation of the hippocampo-accumbens pathway. J. Neurosci. Methods. 2004 Aug 8/15/2004; 137(1): 49-60. PMID: 15196826, PII: S0165027004000469, DOI: 10.1016/j.jneumeth.2004.02.001, ISSN: 0165-0270.

Rojsajjakul T, Wintrode P, Vadrevu R, Robert Matthews C, Smith DL. Multi-state unfolding of the alpha subunit of tryptophan synthase, a TIM barrel protein: insights into the secondary structure of the stable equilibrium intermediates by hydrogen exchange mass spectrometry. J. Mol. Biol. 2004 Jul 7/30/2004; 341(1): 241-53. PMID: 15312776, PII: S0022283604006424, DOI: 10.1016/j.jmb.2004.05.062, ISSN: 0022-2836.

Matthews RA. Inference with legal evidence: common sense is necessary, but not sufficient. Med Sci Law. 2004 Jul; 44(3): 189-92. PMID: 15296239, ISSN: 0025-8024.

Ibarra-Molero B, Zitzewitz JA, Matthews CR. Salt-bridges can stabilize but do not accelerate the folding of the homodimeric coiled-coil peptide GCN4-p1. J. Mol. Biol. 2004 Mar 3/5/2004; 336(5): 989-96. PMID: 15037063, PII: S0022283604000233, DOI: 10.1016/j.jmb.2003.12.069, ISSN: 0022-2836.

Simler BR, Doyle BL, Matthews CR. Zinc binding drives the folding and association of the homo-trimeric gamma-carbonic anhydrase from Methanosarcina thermophila. Protein Eng. Des. Sel [print-electronic]. 2004 Mar; 17(3): 285-91. PMID: 15051865, PII: gzh027, DOI: 10.1093/protein/gzh027, ISSN: 1741-0126.

Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, Horvath TL. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology [print-electronic]. 2003 Nov; 144(11): 5014-21. PMID: 12960023, PII: en.2003-0667, DOI: 10.1210/en.2003-0667, ISSN: 0013-7227.

Viapiano MS, Matthews RT, Hockfield S. A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma. J. Biol. Chem [print-electronic]. 2003 Aug 8/29/2003; 278(35): 33239-47. PMID: 12799382, PII: M303480200, DOI: 10.1074/jbc.M303480200, ISSN: 0021-9258.

Delzell E, Brown DA, Matthews R. Mortality among hourly motor vehicle manufacturing workers. J. Occup. Environ. Med. 2003 Aug; 45(8): 813-30. PMID: 12915783, DOI: 10.1097/01.jom.0000079092.95532.49, ISSN: 1076-2752.

Deyrup LD, Matthews RW. A simple technique for milking the venom of a small parasitic wasp, Melittobia digitata (Hymenoptera: Eulophidae). Toxicon. 2003 Aug; 42(2): 217-8. PMID: 12906893, PII: S0041010103001326, ISSN: 0041-0101.

Wu Y, Matthews CR. Proline replacements and the simplification of the complex, parallel channel folding mechanism for the alpha subunit of Trp synthase, a TIM barrel protein. J. Mol. Biol. 2003 Jul 7/25/2003; 330(5): 1131-44. PMID: 12860133, PII: S002228360300723X, ISSN: 0022-2836.

Horvath TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, Elsworth JD, Sotonyi P, Roth RH, Dietrich EH, Matthews RT, Barnstable CJ, Redmond DE. Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology. 2003 Jul; 144(7): 2757-60. PMID: 12810526, DOI: 10.1210/en.2003-0163, ISSN: 0013-7227.

Arai M, Kataoka M, Kuwajima K, Matthews CR, Iwakura M. Effects of the difference in the unfolded-state ensemble on the folding of Escherichia coli dihydrofolate reductase. J. Mol. Biol. 2003 Jun 6/13/2003; 329(4): 779-91. PMID: 12787677, PII: S0022283603005114, ISSN: 0022-2836.

Trejo LJ, Wheeler KR, Jorgensen CC, Rosipal R, Clanton ST, Matthews B, Hibbs AD, Matthews R, Krupka M. Multimodal neuroelectric interface development. IEEE Trans Neural Syst Rehabil Eng. 2003 Jun; 11(2): 199-204. PMID: 12899274, DOI: 10.1109/TNSRE.2003.814426, ISSN: 1534-4320.

Matthews RA. Homeopathic arnica [letter]. J R Soc Med. 2003 Apr; 96(4): 205-6; author reply 206. PMID: 12668717, PMCID: PMC539465, ISSN: 0141-0768.

Svensson AK, O'Neill JC, Matthews CR. The coordination of the isomerization of a conserved non-prolyl cis peptide bond with the rate-limiting steps in the folding of dihydrofolate reductase. J. Mol. Biol. 2003 Feb 2/14/2003; 326(2): 569-83. PMID: 12559923, PII: S0022283602014444, ISSN: 0022-2836.

Matthews R. Researchers' links with biomed industry lead to bias in clinical trials. New scientist (1971). 2003 Feb 2/1/2003; 177(2380) Sect. 8.

Vadrevu R, Falzone CJ, Matthews CR. Partial NMR assignments and secondary structure mapping of the isolated alpha subunit of Escherichia coli tryptophan synthase, a 29-kD TIM barrel protein. Protein Sci. 2003 Jan; 12(1): 185-91. PMID: 12493842, PMCID: PMC2312393, DOI: 10.1110/ps.0221103, ISSN: 0961-8368.

Wallace LA, Matthews CR. Sequential vs. parallel protein-folding mechanisms: experimental tests for complex folding reactions. Biophys. Chem. 2002 Dec 12/10/2002; 101-102: 113-31. PMID: 12487994, PII: S0301462202001552, ISSN: 0301-4622.

Matthews RA. Response to Worthington on nutritional quality of organic versus conventional fruits, vegetables, and grains [letter]. J Altern Complement Med. 2002 Dec; 8(6): 695-6. PMID: 12614521, DOI: 10.1089/10755530260511685, ISSN: 1075-5535.

Winder DG, Egli RE, Schramm NL, Matthews RT. Synaptic plasticity in drug reward circuitry. Curr. Mol. Med. 2002 Nov; 2(7): 667-76. PMID: 12420805, ISSN: 1566-5240.

Wu Y, Matthews CR. Parallel channels and rate-limiting steps in complex protein folding reactions: prolyl isomerization and the alpha subunit of Trp synthase, a TIM barrel protein. J. Mol. Biol. 2002 Oct 10/18/2002; 323(2): 309-25. PMID: 12381323, PII: S0022283602009221, ISSN: 0022-2836.

Honda Y, Beall C, Delzell E, Oestenstad K, Brill I, Matthews R. Mortality among workers at a talc mining and milling facility. Ann Occup Hyg. 2002 Oct; 46(7): 575-85. PMID: 12270882, ISSN: 0003-4878.

Wu Y, Matthews CR. A cis-prolyl peptide bond isomerization dominates the folding of the alpha subunit of Trp synthase, a TIM barrel protein. J. Mol. Biol. 2002 Sep 9/6/2002; 322(1): 7-13. PMID: 12215410, PII: S0022283602007374, ISSN: 0022-2836.

Matthews RT, Kelly GM, Zerillo CA, Gray G, Tiemeyer M, Hockfield S. Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets. J. Neurosci. 2002 Sep 9/1/2002; 22(17): 7536-47. PMID: 12196577, PII: 22/17/7536, ISSN: 1529-2401.

Knappenberger JA, Smith JE, Thorpe SH, Zitzewitz JA, Matthews CR. A buried polar residue in the hydrophobic interface of the coiled-coil peptide, GCN4-p1, plays a thermodynamic, not a kinetic role in folding. J. Mol. Biol. 2002 Aug 8/2/2002; 321(1): 1-6. PMID: 12139928, PII: S0022283602005922, ISSN: 0022-2836.

Cjnsoli FL, Williams HJ, Vinson SB, Matthews RW, Cooperband MF. Trans-bergamotenes-male pheromone of the ectoparasitoid Melittobia digitata. J. Chem. Ecol. 2002 Aug; 28(8): 1675-89. PMID: 12371819, ISSN: 0098-0331.

Forsyth WR, Matthews CR. Folding mechanism of indole-3-glycerol phosphate synthase from Sulfolobus solfataricus: a test of the conservation of folding mechanisms hypothesis in (beta(alpha))(8) barrels. J. Mol. Biol. 2002 Jul 7/26/2002; 320(5): 1119-33. PMID: 12126630, PII: S0022283602005570, ISSN: 0022-2836.

Steinbach PJ, Ionescu R, Matthews CR. Analysis of kinetics using a hybrid maximum-entropy/nonlinear-least-squares method: application to protein folding. Biophys. J. 2002 Apr; 82(4): 2244-55. PMID: 11916879, PMCID: PMC1302017, PII: S0006-3495(02)75570-7, DOI: 10.1016/S0006-3495(02)75570-7, ISSN: 0006-3495.

Wallace LA, Robert Matthews C. Highly divergent dihydrofolate reductases conserve complex folding mechanisms. J. Mol. Biol. 2002 Jan 1/11/2002; 315(2): 193-211. PMID: 11779239, PII: S0022283602952307, DOI: 10.1006/jmbi.2001.5230, ISSN: 0022-2836.

Yuan W, Matthews RT, Sandy JD, Gottschall PE. Association between protease-specific proteolytic cleavage of brevican and synaptic loss in the dentate gyrus of kainate-treated rats. Neuroscience. 2002; 114(4): 1091-101. PMID: 12379262, PII: S0306452202003470, ISSN: 0306-4522.

Nutt CL, Matthews RT, Hockfield S. Glial tumor invasion: a role for the upregulation and cleavage of BEHAB/brevican. Neuroscientist. 2001 Apr; 7(2): 113-22. PMID: 11496922, ISSN: 1073-8584.

Matthews RT, Gary SC, Zerillo C, Pratta M, Solomon K, Arner EC, Hockfield S. Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member. J. Biol. Chem. 2000 Jul 7/28/2000; 275(30): 22695-703. PMID: 10801887, PII: M909764199, DOI: 10.1074/jbc.M909764199, ISSN: 0021-9258.

O'Neill JC, Robert Matthews C. Localized, stereochemically sensitive hydrophobic packing in an early folding intermediate of dihydrofolate reductase from Escherichia coli. J. Mol. Biol. 2000 Jan 1/28/2000; 295(4): 737-44. PMID: 10656786, PII: S0022-2836(99)93403-4, DOI: 10.1006/jmbi.1999.3403, ISSN: 0022-2836.

Knapp JA, Morris NP, Henderson Z, Matthews RT. Electrophysiological characteristics of non-bursting, glutamate decarboxylase messenger RNA-positive neurons of the medial septum/diagonal band nuclei of guinea-pig and rat. Neuroscience. 2000; 98(4): 661-8. PMID: 10891609, PII: S0306452200001378, ISSN: 0306-4522.

Matthews RT, Ferrante RJ, Klivenyi P, Yang L, Klein AM, Mueller G, Kaddurah-Daouk R, Beal MF. Creatine and cyclocreatine attenuate MPTP neurotoxicity. Exp. Neurol. 1999 May; 157(1): 142-9. PMID: 10222117, PII: S0014-4886(99)97049-8, DOI: 10.1006/exnr.1999.7049, ISSN: 0014-4886.

Matthews RT, Klivenyi P, Mueller G, Yang L, Wermer M, Thomas CE, Beal MF. Novel free radical spin traps protect against malonate and MPTP neurotoxicity. Exp. Neurol. 1999 May; 157(1): 120-6. PMID: 10222114, PII: S0014-4886(99)97045-0, DOI: 10.1006/exnr.1999.7045, ISSN: 0014-4886.

Klivenyi P, Ferrante RJ, Matthews RT, Bogdanov MB, Klein AM, Andreassen OA, Mueller G, Wermer M, Kaddurah-Daouk R, Beal MF. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat. Med. 1999 Mar; 5(3): 347-50. PMID: 10086395, DOI: 10.1038/6568, ISSN: 1078-8956.

Matthews RT. Neurotensin depolarizes cholinergic and a subset of non-cholinergic septal/diagonal band neurons by stimulating neurotensin-1 receptors. Neuroscience. 1999; 94(3): 775-83. PMID: 10579568, PII: S0306-4522(99)00364-4, ISSN: 0306-4522.

Yang L, Matthews RT, Schulz JB, Klockgether T, Liao AW, Martinou JC, Penney JB, Hyman BT, Beal MF. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. J. Neurosci. 1998 Oct 10/15/1998; 18(20): 8145-52. PMID: 9763461, ISSN: 0270-6474.

Schulz JB, Weller M, Matthews RT, Heneka MT, Groscurth P, Martinou JC, Lommatzsch J, von Coelln R, Wüllner U, Löschmann PA, Beal MF, Dichgans J, Klockgether T. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death Differ. 1998 Oct; 5(10): 847-57. PMID: 10203688, DOI: 10.1038/sj.cdd.4400420, ISSN: 1350-9047.

Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc. Natl. Acad. Sci. U.S.A. 1998 Jul 7/21/1998; 95(15): 8892-7. PMID: 9671775, PMCID: PMC21173, ISSN: 0027-8424.

Klivenyi P, Matthews RT, Wermer M, Yang L, MacGarvey U, Becker DA, Natero R, Beal MF. Azulenyl nitrone spin traps protect against MPTP neurotoxicity. Exp. Neurol. 1998 Jul; 152(1): 163-6. PMID: 9682023, PII: S0014-4886(98)96824-8, DOI: 10.1006/exnr.1998.6824, ISSN: 0014-4886.

Keltner JR, Wald LL, Ledden PJ, Chen YC, Matthews RT, Küestermann EH, Baker JR, Rosen BR, Jenkins BG. A localized double-quantum filter for the in vivo detection of brain glucose. Magn Reson Med. 1998 Apr; 39(4): 651-6. PMID: 9543429, ISSN: 0740-3194.

Beal MF, Matthews RT, Tieleman A, Shults CW. Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice. Brain Res. 1998 Feb 2/2/1998; 783(1): 109-14. PMID: 9479058, PII: S000689939701192X, ISSN: 0006-8993.

Matthews RT, Yang L, Jenkins BG, Ferrante RJ, Rosen BR, Kaddurah-Daouk R, Beal MF. Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J. Neurosci. 1998 Jan 1/1/1998; 18(1): 156-63. PMID: 9412496, ISSN: 0270-6474.

Beal MF, Ferrante RJ, Browne SE, Matthews RT, Kowall NW, Brown RH. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann. Neurol. 1997 Oct; 42(4): 644-54. PMID: 9382477, DOI: 10.1002/ana.410420416, ISSN: 0364-5134.

Ayata C, Ayata G, Hara H, Matthews RT, Beal MF, Ferrante RJ, Endres M, Kim A, Christie RH, Waeber C, Huang PL, Hyman BT, Moskowitz MA. Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J. Neurosci. 1997 Sep 9/15/1997; 17(18): 6908-17. PMID: 9278526, ISSN: 0270-6474.

Chen YC, Galpern WR, Brownell AL, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen BR, Jenkins BG. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn Reson Med. 1997 Sep; 38(3): 389-98. PMID: 9339439, ISSN: 0740-3194.

Randall JM, Matthews RT, Stiles MA. Resonant frequencies of standing humans. Ergonomics. 1997 Sep; 40(9): 879-86. PMID: 9306739, DOI: 10.1080/001401397187711, ISSN: 0014-0139.

Ferrante RJ, Shinobu LA, Schulz JB, Matthews RT, Thomas CE, Kowall NW, Gurney ME, Beal MF. Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Ann. Neurol. 1997 Sep; 42(3): 326-34. PMID: 9307254, DOI: 10.1002/ana.410420309, ISSN: 0364-5134.

Schulz JB, Matthews RT, Klockgether T, Dichgans J, Beal MF. The role of mitochondrial dysfunction and neuronal nitric oxide in animal models of neurodegenerative diseases. Mol. Cell. Biochem. 1997 Sep; 174(1-2): 193-7. PMID: 9309687, ISSN: 0300-8177.

Matthews RT, Ferrante RJ, Jenkins BG, Browne SE, Goetz K, Berger S, Chen IY, Beal MF. Iodoacetate produces striatal excitotoxic lesions. J. Neurochem. 1997 Jul; 69(1): 285-9. PMID: 9202321, ISSN: 0022-3042.

Fallon J, Matthews RT, Hyman BT, Beal MF. MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress. Exp. Neurol. 1997 Mar; 144(1): 193-8. PMID: 9126170, PII: S0014-4886(97)96416-5, DOI: 10.1006/exnr.1997.6416, ISSN: 0014-4886.

Matthews RT, Yang L, Beal MF. S-Methylthiocitrulline, a neuronal nitric oxide synthase inhibitor, protects against malonate and MPTP neurotoxicity. Exp. Neurol. 1997 Feb; 143(2): 282-6. PMID: 9056390, PII: S0014-4886(96)96406-7, DOI: 10.1006/exnr.1996.6406, ISSN: 0014-4886.

Matthews RT, Beal MF, Fallon J, Fedorchak K, Huang PL, Fishman MC, Hyman BT. MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice. Neurobiol. Dis. 1997; 4(2): 114-21. PMID: 9331901, PII: S0969-9961(97)90141-8, DOI: 10.1006/nbdi.1997.0141, ISSN: 0969-9961.

Beal MF, Matthews RT. Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. Mol. Aspects Med. 1997; 18 Suppl: S169-79. PMID: 9266519, ISSN: 0098-2997.

Galpern WR, Matthews RT, Beal MF, Isacson O. NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. Neuroreport. 1996 Nov 11/4/1996; 7(15-17): 2639-42. PMID: 8981438, ISSN: 0959-4965.

Hantraye P, Brouillet E, Ferrante R, Palfi S, Dolan R, Matthews RT, Beal MF. Inhibition of neuronal nitric oxide synthase prevents MPTP-induced parkinsonism in baboons. Nat. Med. 1996 Sep; 2(9): 1017-21. PMID: 8782460, ISSN: 1078-8956.

Schulz JB, Huang PL, Matthews RT, Passov D, Fishman MC, Beal MF. Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice. J. Neurochem. 1996 Jul; 67(1): 430-3. PMID: 8667023, ISSN: 0022-3042.

Matthews RT, Beal MF. Increased 3-nitrotyrosine in brains of Apo E-deficient mice. Brain Res. 1996 Apr 4/29/1996; 718(1-2): 181-4. PMID: 8773783, ISSN: 0006-8993.

Schulz JB, Matthews RT, Henshaw DR, Beal MF. Neuroprotective strategies for treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neuroscience. 1996 Apr; 71(4): 1043-8. PMID: 8684608, PII: 0306-4522(95)00527-7, ISSN: 0306-4522.

Kirschner PB, Jenkins BG, Schulz JB, Finkelstein SP, Matthews RT, Rosen BR, Beal MF. NGF, BDNF and NT-5, but not NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals. Brain Res. 1996 Mar 3/25/1996; 713(1-2): 178-85. PMID: 8724989, ISSN: 0006-8993.

Schulz JB, Matthews RT, Beal MF. Role of nitric oxide in neurodegenerative diseases. Curr. Opin. Neurol. 1995 Dec; 8(6): 480-6. PMID: 8845936, ISSN: 1350-7540.

Schulz JB, Matthews RT, Jenkins BG, Ferrante RJ, Siwek D, Henshaw DR, Cipolloni PB, Mecocci P, Kowall NW, Rosen BR. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J. Neurosci. 1995 Dec; 15(12): 8419-29. PMID: 8613773, ISSN: 0270-6474.

Schulz JB, Matthews RT, Jenkins BG, Brar P, Beal MF. Improved therapeutic window for treatment of histotoxic hypoxia with a free radical spin trap. J. Cereb. Blood Flow Metab. 1995 Nov; 15(6): 948-52. PMID: 7593355, DOI: 10.1038/jcbfm.1995.120, ISSN: 0271-678X.

Beal MF, Ferrante RJ, Henshaw R, Matthews RT, Chan PH, Kowall NW, Epstein CJ, Schulz JB. 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. J. Neurochem. 1995 Aug; 65(2): 919-22. PMID: 7616254, ISSN: 0022-3042.

Schulz JB, Henshaw DR, Matthews RT, Beal MF. Coenzyme Q10 and nicotinamide and a free radical spin trap protect against MPTP neurotoxicity. Exp. Neurol. 1995 Apr; 132(2): 279-83. PMID: 7789466, ISSN: 0014-4886.

Schulz JB, Matthews RT, Muqit MM, Browne SE, Beal MF. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. J. Neurochem. 1995 Feb; 64(2): 936-9. PMID: 7530297, ISSN: 0022-3042.

Shults CW, Matthews RT, Altar CA, Hill LR, Langlais PJ. A single intramesencephalic injection of brain-derived neurotrophic factor induces persistent rotational asymmetry in rats. Exp. Neurol. 1994 Feb; 125(2): 183-94. PMID: 8313937, PII: S0014-4886(84)71023-5, DOI: 10.1006/exnr.1994.1023, ISSN: 0014-4886.

Champney TH, Matthews RT. Pineal serotonin is resistant to depletion by serotonergic neurotoxins in rats. J. Pineal Res. 1991 Oct; 11(3-4): 163-7. PMID: 1724461, ISSN: 0742-3098.

Griffith WH, Sim JA, Matthews RT. Electrophysiologic characteristics of basal forebrain neurons in vitro. Adv. Exp. Med. Biol. 1991; 295: 143-55. PMID: 1723243, ISSN: 0065-2598.

Matthews RT, Lee WL. A comparison of extracellular and intracellular recordings from medial septum/diagonal band neurons in vitro. Neuroscience. 1991; 42(2): 451-62. PMID: 1680227, PII: 0306-4522(91)90388-5, ISSN: 0306-4522.

Kelsey JE, Aranow JS, Matthews RT. Context-specific morphine withdrawal in rats: duration and effects of clonidine. Behav. Neurosci. 1990 Oct; 104(5): 704-10. PMID: 2244979, ISSN: 0735-7044.

Peterson SL, Olsta SA, Matthews RT. Cocaine enhances medial prefrontal cortex neuron response to ventral tegmental area activation. Brain Res. Bull. 1990 Feb; 24(2): 267-73. PMID: 2322861, PII: 0361-9230(90)90214-K, ISSN: 0361-9230.

Matthews RT, Champney TH, Frye GD. Effects of (+-)3,4-methylenedioxymethamphetamine (MDMA) on brain dopaminergic activity in rats. Pharmacol. Biochem. Behav. 1989 Aug; 33(4): 741-7. PMID: 2575758, ISSN: 0091-3057.

Matthews RT. Effects of fencamfamine on single unit activity of mesencephalic dopaminergic neurons in rats. J. Neural Transm. 1988; 71(1): 45-55. PMID: 3343595.

Griffith WH, Matthews RT. Electrophysiology of AChE-positive neurons in basal forebrain slices. Neurosci. Lett. 1986 Nov 11/11/1986; 71(2): 169-74. PMID: 3785743, PII: 0304-3940(86)90553-7, ISSN: 0304-3940.

Matthews RT, McMillen BA, Sallis R, Blair D. Effects of BMY 14802, a potential antipsychotic drug, on rat brain dopaminergic function. J. Pharmacol. Exp. Ther. 1986 Oct; 239(1): 124-31. PMID: 2876091, ISSN: 0022-3565.

Matthews RT, German DC. Evidence for a functional role of dopamine type-1 (D-1) receptors in the substantia nigra of rats. Eur. J. Pharmacol. 1986 Jan 1/14/1986; 120(1): 87-93. PMID: 2868905, PII: 0014-2999(86)90644-8, ISSN: 0014-2999.

Matthews RT, Shore PA. Similar potency ratios of amphetamine optical isomers for inhibition of dopamine uptake by synaptosomes of corpus striatum, olfactory tubercle and prefrontal cortex of the rat. Biochem. Pharmacol. 1984 Sep 9/1/1984; 33(17): 2817-9. PMID: 6466390, PII: 0006-2952(84)90702-0, ISSN: 0006-2952.

Matthews RT, McMillen BA, Speciale SG, Jarrah H, Shore PA, Sanghera MK, Shepard PD, German DC. Effects of zoxazolamine and related centrally acting muscle relaxants on nigrostriatal dopaminergic neurons. Brain Res. Bull. 1984 May; 12(5): 479-86. PMID: 6467036, ISSN: 0361-9230.

Matthews RT, German DC. Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine. Neuroscience. 1984 Mar; 11(3): 617-25. PMID: 6717805, ISSN: 0306-4522.

McMillen BA, Matthews RT, Sanghera MK, Shepard PD, German DC. Dopamine receptor antagonism by the novel antianxiety drug, buspirone. J. Neurosci. 1983 Apr; 3(4): 733-8. PMID: 6131948, ISSN: 0270-6474.

Matthews RT, Chiou CY. Effects of diethylcholine in two animal models of Parkinsonism tremors. Eur. J. Pharmacol. 1979 Jun; 56(1-2): 159-62. PMID: 467505, ISSN: 0014-2999.

Matthews RT, Chiou CY. Effects of acute and chronic injections of carbachol in the rat caudate nucleus. Neuropharmacology. 1979 Mar; 18(3): 291-4. PMID: 440537, ISSN: 0028-3908.

Matthews RT, Chiou CY. Choline and diethylcholine transport into a cholinergic clone of neuroblastoma cells. Biochem. Pharmacol. 1979; 28(3): 405-9. PMID: 426858, PII: 0006-2952(79)90106-0, ISSN: 0006-2952.

Matthews RT, Chiou CY. Cholinergic stimulation of the caudate nucleus in rats: a model of Parkinson's disease. Neuropharmacology. 1978 Oct; 17(10): 879-82. PMID: 745684, ISSN: 0028-3908.