Nishitha M. Reddy, M.B.B.S.

Associate Professor
Faculty Appointments
Associate Professor of Medicine
M.S.C.I., Clinical Investigation , Vanderbilt University, Nashville, TennesseeM.B.B.S., Ambedkar Medical College, Bangalore, India
Office Address
777 PRB
TN 37232-5505
Research Keywords
Non Hodgkins Lymphoma, chronic Lymphocytic Leukemia, Investigational therapies
Barr PM, Brown JR, Hillmen P, O'Brien S, Barrientos JC, Reddy NM, Coutre S, Mulligan SP, Jaeger U, Furman RR, Cymbalista F, Montillo M, Dearden C, Robak T, Moreno C, Pagel JM, Burger JA, Suzuki S, Sukbuntherng J, Cole G, James DF, Byrd JC. Impact of ibrutinib dose adherence on therapeutic efficacy in patients with previously treated CLL/SLL. Blood [print-electronic]. 2017 Apr 4/3/2017; PMID: 28373262, PII: blood-2016-12-737346, DOI: 10.1182/blood-2016-12-737346, ISSN: 1528-0020.

Sethi TK, Basdag B, Bhatia N, Moslehi J, Reddy NM. Beyond Anthracyclines: Preemptive Management of Cardiovascular Toxicity in the Era of Targeted Agents for Hematologic Malignancies. Curr Hematol Malig Rep [print-electronic]. 2017 Feb 2/23/2017; PMID: 28233150, PII: 10.1007/s11899-017-0369-y, DOI: 10.1007/s11899-017-0369-y, ISSN: 1558-822X.

Costa LJ, Maddocks K, Epperla N, Reddy NM, Karmali R, Umyarova E, Bachanova V, Costa C, Glenn MJ, Chavez JC, Calzada O, Lansigan F, Nasheed H, Barta SK, Zhou Z, Jaglal M, Chhabra S, Hernandez-Ilizaliturri F, Xavier AC, Mehta A, Peker D, Forero-Torres A, Al-Mansour Z, Evens AM, Cohen JB, Flowers CR, Fenske TS, Hamadani M. Diffuse large B-cell lymphoma with primary treatment failure: Ultra-high risk features and benchmarking for experimental therapies. Am. J. Hematol. 2017 Feb; 92(2): 161-70. PMID: 27880984, DOI: 10.1002/ajh.24615, ISSN: 1096-8652.

Reddy NM, Greer JP, Morgan DS, Chen H, Park SI, Richards KL. A phase II randomized study of lenalidomide or lenalidomide and rituximab as maintenance therapy following standard chemotherapy for patients with high/high-intermediate risk diffuse large B-cell lymphoma. Leukemia [print-electronic]. 2017 Jan; 31(1): 241-4. PMID: 27654851, PMCID: PMC5214342, PII: leu2016255, DOI: 10.1038/leu.2016.255, ISSN: 1476-5551.

Kharfan-Dabaja MA, Kumar A, Hamadani M, Stilgenbauer S, Ghia P, Anasetti C, Dreger P, Montserrat E, Perales MA, Alyea EP, Awan FT, Ayala E, Barrientos JC, Brown JR, Castro JE, Furman RR, Gribben J, Hill BT, Mohty M, Moreno C, O'Brien S, Pavletic SZ, Pinilla-Ibarz J, Reddy NM, Sorror M, Bredeson C, Carpenter P, Savani BN. Clinical Practice Recommendations for Use of Allogeneic Hematopoietic Cell Transplantation in Chronic Lymphocytic Leukemia on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation. Biol. Blood Marrow Transplant [print-electronic]. 2016 Dec; 22(12): 2117-25. PMID: 27660167, PMCID: PMC5116249, PII: S1083-8791(16)30353-6, DOI: 10.1016/j.bbmt.2016.09.013, ISSN: 1523-6536.

Landsburg DJ, Falkiewicz MK, Petrich AM, Chu BA, Behdad A, Li S, Medeiros LJ, Cassaday RD, Reddy NM, Bast MA, Vose JM, Kruczek KR, Smith SE, Patel P, Hernandez-Ilizaliturri F, Karmali R, Rajguru S, Yang DT, Maly JJ, Blum KA, Zhao W, Vanslambrouck C, Nabhan C. Sole rearrangement but not amplification of MYC is associated with a poor prognosis in patients with diffuse large B cell lymphoma and B cell lymphoma unclassifiable. Br. J. Haematol [print-electronic]. 2016 Nov; 175(4): 631-40. PMID: 27469075, PMCID: PMC5118108, DOI: 10.1111/bjh.14282, ISSN: 1365-2141.

Bradshaw MJ, Pawate S, Bloch KC, Moots P, Reddy NM. Clinical Reasoning: A 52-year-old man with diplopia and ataxia. Neurology. 2016 Sep 9/27/2016; 87(13): e140-3. PMID: 27672172, PII: WNL.0000000000003150, DOI: 10.1212/WNL.0000000000003150, ISSN: 1526-632X.

Reddy NM, Sethi TK. Beyond Epstein-Barr virus: genetic predisposition of natural killer T-cell lymphoma. Lancet Oncol [print-electronic]. 2016 Sep; 17(9): 1176-7. PMID: 27470080, PII: S1470-2045(16)30205-4, DOI: 10.1016/S1470-2045(16)30205-4, ISSN: 1474-5488.

Nguyen VT, Pophali PA, Tsai JP, Jagadeesh D, Dean RM, Pohlman B, Morgan DS, Greer JP, Smith MR, Hill BT, Reddy NM. Early stage, bulky Hodgkin lymphoma patients have a favorable outcome when treated with or without consolidative radiotherapy: potential role of PET scan in treatment planning [letter]. Br. J. Haematol [print-electronic]. 2016 Jul 7/13/2016; PMID: 27409578, DOI: 10.1111/bjh.14236, ISSN: 1365-2141.

Wang XJ, Seegmiller AC, Reddy NM, Li S. CD30 expression and its correlation with MYC rearrangement in de novo diffuse large B-cell lymphoma. Eur. J. Haematol [print-electronic]. 2016 Jul; 97(1): 39-47. PMID: 26340843, DOI: 10.1111/ejh.12680, ISSN: 1600-0609.

Li S, Saksena A, Desai P, Xu J, Zuo Z, Lin P, Tang G, Yin CC, Seegmiller A, Jorgensen JL, Miranda RN, Reddy NM, Bueso-Ramos C, Medeiros LJ. Prognostic impact of history of follicular lymphoma, induction regimen and stem cell transplant in patients with MYC/BCL2 double hit lymphoma. Oncotarget. 2016 Jun 6/21/2016; 7(25): 38122-32. PMID: 27203548, PMCID: PMC5122376, PII: 9473, DOI: 10.18632/oncotarget.9473, ISSN: 1949-2553.

Li S, Weiss VL, Wang XJ, Desai PA, Hu S, Yin CC, Tang G, Reddy NM, Medeiros LJ, Lin P. High-grade B-cell Lymphoma With MYC Rearrangement and Without BCL2 and BCL6 Rearrangements Is Associated With High P53 Expression and a Poor Prognosis. Am. J. Surg. Pathol. 2016 Feb; 40(2): 253-61. PMID: 26448193, DOI: 10.1097/PAS.0000000000000542, ISSN: 1532-0979.

Perales MA, Ceberio I, Armand P, Burns LJ, Chen R, Cole PD, Evens AM, Laport GG, Moskowitz CH, Popat U, Reddy NM, Shea TC, Vose JM, Schriber J, Savani BN, Carpenter PA. Role of cytotoxic therapy with hematopoietic cell transplantation in the treatment of Hodgkin lymphoma: guidelines from the American Society for Blood and Marrow Transplantation. Biol. Blood Marrow Transplant [print-electronic]. 2015 Jun; 21(6): 971-83. PMID: 25773017, PII: S1083-8791(15)00152-4, DOI: 10.1016/j.bbmt.2015.02.022, ISSN: 1523-6536.

Iams WT, Hames ML, Tsai JP, Dahlman KB, Talbott MS, Richards KL, Reddy NM. Increased serum tumor necrosis factor a levels in patients with lenalidomide-induced hypothyroidism. Exp. Hematol [print-electronic]. 2015 Feb; 43(2): 74-8. PMID: 25448491, PII: S0301-472X(14)00715-2, DOI: 10.1016/j.exphem.2014.10.009, ISSN: 1873-2399.

Reddy NM, Perales MA. Stem cell transplantation in Hodgkin lymphoma. Hematol. Oncol. Clin. North Am [print-electronic]. 2014 Dec; 28(6): 1097-112. PMID: 25459181, PII: S0889-8588(14)00111-7, DOI: 10.1016/j.hoc.2014.08.011, ISSN: 1558-1977.

Hamadani M, Hari PN, Zhang Y, Carreras J, Akpek G, Aljurf MD, Ayala E, Bachanova V, Chen AI, Chen YB, Costa LJ, Fenske TS, Freytes CO, Ganguly S, Hertzberg MS, Holmberg LA, Inwards DJ, Kamble RT, Kanfer EJ, Lazarus HM, Marks DI, Nishihori T, Olsson R, Reddy NM, Rizzieri DA, Savani BN, Solh M, Vose JM, Wirk B, Maloney DG, Smith SM, Montoto S, Saber W, Alpdogan O, Cashen A, Dandoy C, Finke R, Gale R, Gibson J, Hsu JW, Janakiraman N, Laughlin MJ, Lill M, Cairo MS, Munker R, Rowlings PA, Schouten HC, Shea TC, Stiff PJ, Waller EK. Early failure of frontline rituximab-containing chemo-immunotherapy in diffuse large B cell lymphoma does not predict futility of autologous hematopoietic cell transplantation. Biol. Blood Marrow Transplant [print-electronic]. 2014 Nov; 20(11): 1729-36. PMID: 25008330, PMCID: PMC4194275, PII: S1083-8791(14)00403-0, DOI: 10.1016/j.bbmt.2014.06.036, ISSN: 1523-6536.

Iams W, Reddy NM. Consolidative autologous hematopoietic stem-cell transplantation in first remission for non-Hodgkin lymphoma: current indications and future perspective. Ther Adv Hematol. 2014 Oct; 5(5): 153-67. PMID: 25324956, PMCID: PMC4199091, PII: 10.1177_2040620714547327, DOI: 10.1177/2040620714547327, ISSN: 2040-6207.

Wirk B, Fenske TS, Hamadani M, Zhang MJ, Hu ZH, Akpek G, Aljurf MD, Armand P, Ayala E, Bachanova V, Bolwell B, Cairo MS, Cashen A, Chen YB, Costa LJ, Farhan S, Freytes CO, Gajewski JL, Gibson J, Hale GA, Holmberg LA, Hsu JW, Inwards DJ, Kamble RT, Maharaj D, Maziarz RT, Munker R, Nath R, Reddy NM, Reeder CB, Rizzieri DA, Sauter CS, Savani BN, Schouten HC, Sureda A, Vose JM, Waller EK, Wiernik PH, Gale RP, Burns LJ, Saber W. Outcomes of hematopoietic cell transplantation for diffuse large B cell lymphoma transformed from follicular lymphoma. Biol. Blood Marrow Transplant [print-electronic]. 2014 Jul; 20(7): 951-9. PMID: 24641828, PMCID: PMC4060436, PII: S1083-8791(14)00163-3, DOI: 10.1016/j.bbmt.2014.03.014, ISSN: 1523-6536.

Johnson DB, Dahlman KH, Knol J, Gilbert J, Puzanov I, Means-Powell J, Balko JM, Lovly CM, Murphy BA, Goff LW, Abramson VG, Crispens MA, Mayer IA, Berlin JD, Horn L, Keedy VL, Reddy NM, Arteaga CL, Sosman JA, Pao W. Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel. Oncologist [print-electronic]. 2014 Jun; 19(6): 616-22. PMID: 24797823, PMCID: PMC4041676, PII: theoncologist.2014-0011, DOI: 10.1634/theoncologist.2014-0011, ISSN: 1549-490X.

Bodiford A, Bodge M, Talbott MS, Reddy NM. Profile of belinostat for the treatment of relapsed or refractory peripheral T-cell lymphoma. Onco Targets Ther. 2014; 7: 1971-7. PMID: 25368524, PMCID: PMC4216035, PII: ott-7-1971, DOI: 10.2147/OTT.S59269, ISSN: 1178-6930.

Kun L, Hernandez-Ilizaliturri FJ, Reddy NM. Novel therapeutic strategies for cutaneous T-cell lymphoma in advanced stages. Semin. Hematol [print-electronic]. 2014 Jan; 51(1): 35-41. PMID: 24468314, PII: S0037-1963(13)00154-6, DOI: 10.1053/j.seminhematol.2013.11.004, ISSN: 1532-8686.

Reddy NM, Evens AM. Chemotherapeutic advancements in peripheral T-cell lymphoma. Semin. Hematol [print-electronic]. 2014 Jan; 51(1): 17-24. PMID: 24468312, PII: S0037-1963(13)00156-X, DOI: 10.1053/j.seminhematol.2013.11.006, ISSN: 1532-8686.

Reddy NM, Savani BN. Management of T-cell lymphomas: overcoming challenges and choosing the best treatment [editorial]. Semin. Hematol [print-electronic]. 2014 Jan; 51(1): 1-4. PMID: 24468310, PII: S0037-1963(13)00159-5, DOI: 10.1053/j.seminhematol.2013.11.009, ISSN: 1532-8686.

Reddy NM, Oluwole O, Greer JP, Engelhardt BG, Jagasia MH, Savani BN. Outcomes of autologous or allogeneic stem cell transplantation for non-Hodgkin lymphoma. Exp. Hematol [print-electronic]. 2014 Jan; 42(1): 39-45. PMID: 24096123, PII: S0301-472X(13)00747-9, DOI: 10.1016/j.exphem.2013.09.012, ISSN: 1873-2399.

Seegmiller AC, Kim AS, Mosse CA, Levy MA, Thompson MA, Kressin MK, Jagasia MH, Strickland SA, Reddy NM, Marx ER, Sinkfield KJ, Pollard HN, Plummer WD, Dupont WD, Shultz EK, Dittus RS, Stead WW, Santoro SA, Zutter MM. Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Am. J. Clin. Pathol. 2013 Nov; 140(5): 643-50. PMID: 24124142, PMCID: PMC4159763, PII: 140/5/643, DOI: 10.1309/AJCP8CKE9NEINQFL, ISSN: 1943-7722.

Stevens PL, Reddy NM. Immune surveillance and lymphoid malignancy in immunocompromised host. Am J Blood Res [electronic-print]. 2013; 3(2): 91-101. PMID: 23675561, PMCID: PMC3649811, ISSN: 2160-1992.

Stover DG, Reddy VK, Shyr Y, Savani BN, Reddy N. Long-term impact of prior rituximab therapy and early lymphocyte recovery on auto-SCT outcome for diffuse large B-cell lymphoma. Bone Marrow Transplant [print-electronic]. 2012 Jan; 47(1): 82-7. PMID: 21358691, PII: bmt201129, DOI: 10.1038/bmt.2011.29, ISSN: 1476-5365.

Reddy N, Rezvani K, Barrett AJ, Savani BN. Strategies to prevent EBV reactivation and posttransplant lymphoproliferative disorders (PTLD) after allogeneic stem cell transplantation in high-risk patients. Biol. Blood Marrow Transplant [print-electronic]. 2011 May; 17(5): 591-7. PMID: 20732435, PMCID: PMC3763478, PII: S1083-8791(10)00346-0, DOI: 10.1016/j.bbmt.2010.08.007, ISSN: 1523-6536.

Reddy N, Thompson-Arildsen MA. Hodgkin's lymphoma: Richter's transformation of chronic lymphocytic leukemia involving the liver. J. Clin. Oncol [print-electronic]. 2010 Oct 10/10/2010; 28(29): e543-4. PMID: 20713878, PII: JCO.2010.29.3050, DOI: 10.1200/JCO.2010.29.3050, ISSN: 1527-7755.

Reddy N, Czuczman MS. Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: preclinical mechanistic studies. Ann. Oncol [print-electronic]. 2010 Sep; 21(9): 1756-64. PMID: 20133382, PII: mdq009, DOI: 10.1093/annonc/mdq009, ISSN: 1569-8041.

Zelenetz AD, Abramson JS, Advani RH, Andreadis CB, Byrd JC, Czuczman MS, Fayad L, Forero A, Glenn MJ, Gockerman JP, Gordon LI, Harris NL, Hoppe RT, Horwitz SM, Kaminski MS, Kim YH, Lacasce AS, Mughal TI, Nademanee A, Porcu P, Press O, Prosnitz L, Reddy N, Smith MR, Sokol L, Swinnen L, Vose JM, Wierda WG, Yahalom J, Yunus F. NCCN Clinical Practice Guidelines in Oncology: non-Hodgkin's lymphomas. J Natl Compr Canc Netw. 2010 Mar; 8(3): 288-334. PMID: 20202462.

Nishitha Reddy. Treatment for Lymphoma and Leukemias- With New Effective Therapies, is there any concern for Cardiac Issues?. 2010.

Reddy N, Greer JP. Primary bone lymphoma: a set of unique problems in management. Leuk. Lymphoma. 2010 Jan; 51(1): 1-2. PMID: 20055655, DOI: 10.3109/10428190903470877, ISSN: 1029-2403.

Olalekan Oluwole, Susan Greenhut, Bipin N Savani, and Nishitha Reddy. Surveillance in acute lymphoblastic leukemia. PATIENT SURVEILLANCE AFTER CANCER TREATMENT- An international perspective 2nd edition. 2010.

Bipin Savani and Nishitha Reddy. New Insights on Hematopoietic Cell Transplantation. [place unknown: publisher unknown]; 2010.

Claudio Mosse, Utpal Dave, Nishitha Reddy, Christine Lovly and John P. Greer. Molecular Pathology of Hematolymphoid Diseases. [place unknown: publisher unknown]; 2010.

Savani BN, Mielke S, Reddy N, Goodman S, Jagasia M, Rezvani K. Management of relapse after allo-SCT for AML and the role of second transplantation. Bone Marrow Transplant [print-electronic]. 2009 Dec; 44(12): 769-77. PMID: 19855439, PII: bmt2009300, DOI: 10.1038/bmt.2009.300, ISSN: 1476-5365.

Reddy N, Goodman S, Savani BN. Prophylactic intravenous immunoglobulin does not have a role in hematopoietic stem-cell transplantation: is the evidence clear? [letter]. J. Clin. Oncol [print-electronic]. 2009 May 5/1/2009; 27(13): 2296-7; author reply 2297. PMID: 19307488, PII: JCO.2009.22.0897, DOI: 10.1200/JCO.2009.22.0897, ISSN: 1527-7755.

Savani BN, Goodman S, Reddy N. Does extra alemtuzumab remove the graft-versus-leukemia effect after allogeneic stem cell transplantation in chronic lymphocytic leukemia? [letter]. Biol. Blood Marrow Transplant. 2009 Apr; 15(4): 517-8. PMID: 19285641, PII: S1083-8791(09)00004-4, DOI: 10.1016/j.bbmt.2008.12.511, ISSN: 1523-6536.

Reddy N, Abel TW, Jagasia M, Morgan D, Weaver K, Greer J. Progressive multifocal leukoencephalopathy in a patient with follicular lymphoma treated with multiple courses of rituximab. Leuk. Lymphoma. 2009 Mar; 50(3): 460-2. PMID: 19266387, PII: 909254836, DOI: 10.1080/10428190802695827, ISSN: 1029-2403.

Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, Roth M, Vaughn M, Knight J, Wallace P, Czuczman MS. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo. Br. J. Haematol [print-electronic]. 2008 Jan; 140(1): 36-45. PMID: 17995965, PII: BJH6841, DOI: 10.1111/j.1365-2141.2007.06841.x, ISSN: 1365-2141.

Bipin N Savani, Nishitha Reddy, Sharon Adams and John A Barrett. Optimizing Natural Killer Activity in Allogeneic Stem Cell Transplantation. American Society of Histocompatibility and immunogenetics. 2008.

Reddy NM, Sullivan MA, Hahn TE, Battiwalla M, Smiley SL, McCarthy PL. Association of squamous cell carcinoma of the oral cavity in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant [print-electronic]. 2007 Nov; 40(9): 907-9. PMID: 17724441, PII: 1705833, DOI: 10.1038/sj.bmt.1705833, ISSN: 0268-3369.

Reddy N, Karampelas I, Chanan-Khan A, Fenstermaker R, Padmanabhan S. Aggressive relapse of multiple myeloma with intracerebral extension and associated hemorrhage. Leuk. Lymphoma. 2007 Jun; 48(6): 1228-30. PMID: 17577791, PII: 779656423, DOI: 10.1080/10428190701272371, ISSN: 1042-8194.

Reddy N, Yu J, Fakih MG. Toxicities and survival among octogenarians and nonagenarians with colorectal cancer treated with chemotherapy or concurrent chemoradiation therapy. Clin Colorectal Cancer. 2007 Jan; 6(5): 362-6. PMID: 17311701, PII: S1533-0028(11)70264-X, DOI: 10.3816/CCC.2007.n.005, ISSN: 1533-0028.

Reddy N, Hernandez-Ilizaliturri F, Knight J, Czuczman M. Antitumor effects of Lenalidomide in combination with IDEC114 (anti-CD80) in lymphoma bearing Severe combined Immunodeficiency (SCID) mouse model. American Society of Clinical Oncology. 2007.

Nishitha Reddy and Myron Czuczman. Advancements in Treating Lymphomas. Coping Magazine. 2006.

Hernandez-Ilizaliturri FJ, Reddy N, Holkova B, Ottman E, Czuczman MS. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin. Cancer Res. 2005 Aug 8/15/2005; 11(16): 5984-92. PMID: 16115943, PII: 11/16/5984, DOI: 10.1158/1078-0432.CCR-05-0577, ISSN: 1078-0432.

Nishitha Reddy and Bipin N Savani. New insights into the role of allogeneic stem cell transplantation in patients with transformed non-Hodgkins lymphoma.

Jason Tedesco, Julianne Qualtieri, David Head, Bipin Savani and N Reddy. A high prevalence of obesity in Acute Promyelocytic Leukemia (APL) - Implications of targeted therapy to control obesity and APL prevention.