Eric L. Grogan, M.D.

Associate Professor

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Faculty Appointments
Associate Professor of Thoracic Surgery Associate Professor of MedicineAssociate Professor of Radiology & Radiological Sciences
M.P.H., Surgical Health Services Research, Vanderbilt University, Nashville, TennesseeM.D., Medicine, Vanderbilt University, Nashville, TennesseeB.S., Chemistry, David Lipscomb University, Nashville, Tennessee
Office Address
609 Oxford House
Nashville, TN 37232-4682
Research Description
A recently recruited member of the Department of Thoracic Surgery, Eric L. Grogan, M.D., M.P.H., has also been awarded the VPSD grant. His grant entitled “Predicting Lung Cancer with a Serum Protein Test” is a translational research project that is using serum proteomics, epidemiology, and imaging techniques to predict lung cancer in patients with pulmonary nodules. “With the increasing use of Computed Tomography (CT scan), we are finding more pulmonary nodules. Most of these nodules are benign, but some are malignant and determining which ones are cancerous is challenging. Currently we use a combination of the patient’s risk factors and imaging to decide which nodules are high risk for cancer and need surgical excision. However, 20 percent of our operations on these suspicious nodules result in a benign diagnosis. This puts our patients at risk and is costly to the medical system.”
“Using a multidisciplinary approach, we have a team of basic scientists, translational scientists pulmonologists, thoracic surgeons, epidemiologists, and health economists. We are working together to develop a cost-effective blood test for patients with suspected lung cancer. Dr. Pierre Massion’s laboratory (VICC Spore Grant) has developed a simple blood test that can predict patients who have all stages of lung cancer. Using MALDI – MS techniques, they have identified a seven protein signature that is highly predictive of lung cancer. Together, we are determining the accuracy of this serum proteomic test in patients with lung nodules and are combining this serum proteomic test with the patient’s risk factors and imaging characteristics. A highly specific test will help reduce unnecessary surgery while not missing any cases of lung cancer. We are also evaluating the accuracy of this test in predicting lung cancer recurrence.”
Research Keywords
My interests are using proteomics, genomics, and epidemiology to develop personalized diagnostic and treatment options for patients with lung cancer. In addition we are evaluating the most effective new strategies for the diagnosis and treatment of lung cancer.
Grogan EL, Deppen S, Pecot CV, Putnam JB, Nesbitt JC, Shyr Y, Rajanbabu R, Ory B, Lambright ES, Massion PP. Diagnostic characteristics of a serum biomarker in patients with positron emission tomography scans. Ann. Thorac. Surg. 2010 Jun; 89(6): 1724-8; discussion 1728. PMID: 20494018, PMCID: PMC3026702, PII: S0003-4975(10)00602-8, DOI: 10.1016/j.athoracsur.2010.03.008, ISSN: 1552-6259.

Hennessy SA, Grogan EL, Harthun NL, Jones DR, Kozower BD, Ailawadi G, Lau CL. Transplant pneumonectomy in a patient with an acutely thrombosed allograft. Ann. Thorac. Surg. 2010 Mar; 89(3): 975-7. PMID: 20172174, PII: S0003-4975(09)01592-6, DOI: 10.1016/j.athoracsur.2009.07.085, ISSN: 1552-6259.

Grogan EL, Stukenborg GJ, Nagji AS, Simmons W, Kozower BD, Jones DR, Daniel TM. Radiotracer-guided thoracoscopic resection is a cost-effective technique for the evaluation of subcentimeter pulmonary nodules. Ann. Thorac. Surg. 2008 Sep; 86(3): 934-40; discussion 934. PMID: 18721586, PII: S0003-4975(08)00988-0, DOI: 10.1016/j.athoracsur.2008.05.002, ISSN: 1552-6259.

Grogan EL, Jones DR. VATS lobectomy is better than open thoracotomy: what is the evidence for short-term outcomes?. Thorac Surg Clin. 2008 Aug; 18(3): 249-58. PMID: 18831499, PII: S1547-4127(08)00044-3, DOI: 10.1016/j.thorsurg.2008.04.007, ISSN: 1547-4127.

Grogan EL, Jones DR, Kozower BD, Simmons WD, Daniel TM. Identification of small lung nodules: technique of radiotracer-guided thoracoscopic biopsy. Ann. Thorac. Surg. 2008 Feb; 85(2): S772-7. PMID: 18222215, PII: S0003-4975(07)02399-5, DOI: 10.1016/j.athoracsur.2007.10.105, ISSN: 1552-6259.

Murff HJ, France DJ, Blackford J, Grogan EL, Yu C, Speroff T, Pichert JW, Hickson GB. Relationship between patient complaints and surgical complications. Qual Saf Health Care. 2006 Feb; 15(1): 13-6. PMID: 16456204, PMCID: PMC2564001, PII: 15/1/13, DOI: 10.1136/qshc.2005.013847, ISSN: 1475-3901.

Norris PR, Morris JA, Ozdas A, Grogan EL, Williams AE. Heart rate variability predicts trauma patient outcome as early as 12 h: implications for military and civilian triage. J. Surg. Res [print-electronic]. 2005 Nov; 129(1): 122-8. PMID: 15978622, PII: S0022-4804(05)00223-4, DOI: 10.1016/j.jss.2005.04.024, ISSN: 0022-4804.

France DJ, Stiles R, Gaffney EA, Seddon MR, Grogan EL, Nixon WR, Speroff T. Crew resource management training--clinicians' reactions and attitudes. AORN J. 2005 Aug; 82(2): 213-24; quiz 225. PMID: 16153049, ISSN: 0001-2092.

Grogan EL. Should I lie about my work hours this week? [letter]. J. Am. Coll. Surg. 2005 Apr; 200(4): 635-6. PMID: 15804483, PII: S1072-7515(04)01483-8, DOI: 10.1016/j.jamcollsurg.2004.12.001, ISSN: 1072-7515.

Poulose BK, Holzman MD, Lao OB, Grogan EL, Goldstein RE. Laparoscopic adrenalectomy: 100 resections with clinical long-term follow-up. Surg Endosc [print-electronic]. 2005 Mar; 19(3): 379-85. PMID: 15624053, DOI: 10.1007/s00464-004-8914-x, ISSN: 1432-2218.

Poulose BK, Scholz S, Moore DE, Schmidt CR, Grogan EL, Lao OB, Nanney L, Davidson J, Holzman MD. Physiologic properties of small intestine submucosa. J. Surg. Res. 2005 Feb; 123(2): 262-7. PMID: 15680388, PII: S0022-4804(04)00534-7, DOI: 10.1016/j.jss.2004.08.011, ISSN: 0022-4804.

Grogan EL, Morris JA, Dittus RS, Moore DE, Poulose BK, Diaz JJ, Speroff T. Cervical spine evaluation in urban trauma centers: lowering institutional costs and complications through helical CT scan. J. Am. Coll. Surg. 2005 Feb; 200(2): 160-5. PMID: 15664088, PII: S1072-7515(04)01357-2, DOI: 10.1016/j.jamcollsurg.2004.10.019, ISSN: 1072-7515.

Grogan EL, Norris PR, Speroff T, Ozdas A, France DJ, Harris PA, Jenkins JM, Stiles R, Dittus RS, Morris JA. Volatility: a new vital sign identified using a novel bedside monitoring strategy. J Trauma. 2005 Jan; 58(1): 7-12; discussion 12. PMID: 15674143, PII: 00005373-200501000-00002, ISSN: 0022-5282.

Grogan EL, Stiles RA, France DJ, Speroff T, Morris JA, Nixon B, Gaffney FA, Seddon R, Pinson CW. The impact of aviation-based teamwork training on the attitudes of health-care professionals. J. Am. Coll. Surg. 2004 Dec; 199(6): 843-8. PMID: 15555963, PII: S1072-7515(04)01175-5, DOI: 10.1016/j.jamcollsurg.2004.08.021, ISSN: 1072-7515.

Grogan EL, Speroff T, Deppen SA, Roumie CL, Elasy TA, Dittus RS, Rosenbloom ST, Holzman MD. Improving documentation of patient acuity level using a progress note template. J. Am. Coll. Surg. 2004 Sep; 199(3): 468-75. PMID: 15325618, PII: S1072-7515(04)00702-1, DOI: 10.1016/j.jamcollsurg.2004.05.254, ISSN: 1072-7515.

Grogan EL, Morris JA, Norris PR, France DJ, Ozdas A, Stiles RA, Harris PA, Dawant BM, Speroff T. Reduced heart rate volatility: an early predictor of death in trauma patients. Ann. Surg. 2004 Sep; 240(3): 547-54; discussion 554. PMID: 15319726, PMCID: PMC1356445, PII: 00000658-200409000-00016, ISSN: 0003-4932.

Roumie CL, Grogan EL, Falbe W, Awad J, Speroff T, Dittus RS, Elasy TA. A three-part intervention to change the use of hormone replacement therapy in response to new evidence. Ann. Intern. Med. 2004 Jul 7/20/2004; 141(2): 118-25. PMID: 15262667, PII: 141/2/118, ISSN: 1539-3704.

Diaz JJ, Gray BW, Dobson JM, Grogan EL, May AK, Miller R, Guy J, O'Neill P, Morris JA. Repair of giant abdominal hernias: does the type of prosthesis matter?. Am Surg. 2004 May; 70(5): 396-401; discussion 401. PMID: 15156946, ISSN: 0003-1348.

Grogan EL, Nylander WA, Shaffer D. Living-related transplantation of an ectopic pelvic kidney. Transplantation. 2004 Mar 3/27/2004; 77(6): 953. PMID: 15077048, PII: 00007890-200403270-00034, ISSN: 0041-1337.

Grogan EL, Wheeler WG, Ross CB. Management of incidentally discovered cervical paragangliomas: report of two cases and review of current issues. J Ky Med Assoc. 1999 Dec; 97(12): 559-65. PMID: 10618853, ISSN: 0023-0294.