John A. Oates, M.D.


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Faculty Appointments
Professor of Medicine Thomas F. Frist Sr. Chair in MedicineProfessor of Pharmacology
M.D., MEDICINE, Wake Forest University, Winston-Salem, North CarolinaB.S., Wake Forest University, Winston-Salem, North Carolina
Office Address
514-A RRB
2200 Pierce Ave
TN 37232-6602
Research Description
Our research has focused on the participation of the oxygenated metabolites of arachidonic acid (eicosanoids) in the pathophysiology and treatment of human diseases. One pathway of arachidonic acid oxygenation leads to the formation of prostaglandins and related molecules; the initial step in their formation is catalyzed by one of the two cyclooxygenase enzymes, which are inhibited by aspirin and the nonsteroidal anti-inflammatory drugs. One of these enzymes, cyclooxygenase-2 (COX-2), is an inducible enzyme, the biosynthesis of which is stimulated by growth factors, cytokines, and endotoxin, and is inhibited by glucocorticoids.
We are investigating the mechanisms for interindividual variation in the effects of aspirin as an antiplatelet drug employed as a cardioprotective agent. This research is based on our discovery that the irrreversible inhibition of the platelet cycloxygenase-1 is regulated by the redox status of the enzyme. Also under study are the changes in the platelet proteome associated with loss of aspirin's effect on continued administration.
We have found that the delayed vasospasm that can cause severe neurological deficits in subarachnoid hemorrhage is temporally associated with and hypothetically caused by lipid peroxidation resulting from hemoglobin radicals. Our research has identified agents that can inhibit such hemoprotein lcatalyzed ipid peroxidation in vitro and in vivo. We are now investigating a series of hemprotein reductants to determine the compounds most potent in reducing hemoprotein catalyzed lipid peroxidation with the aim of developing a treatment strategy for not only subarachnoid hemorrhage, but also other diseases in which hemoprotein catalyzed lipid peroxidation contributes to the pathophysiology including rhabdomyolysis, myocardial infarction, sickle cell disease, and malaria.
Work on Alzheimer's disease addresses a highly reactive keto-aldehyde product of the cyclooxygenases called levuglandin. We discovered that levuglandins can greatly accelerate the oligomerization of amyloid beta and that the oligomers so formed are neurotoxic. Moreover, we have developed mass spectrometric methods for measuring protein adducts of the levuglandins, and find that they are increased by 12 fold in the brains of patients who died of Alzheimer's disease. W are now working with scavengers of the levuglandins that prevent their reaction with proteins to determine their effects in transgenic mouse models of Alzheimer's disease. Other work addresses mechanisms for decreasing amyloid beta biosynthesis by enhancing cleavage of its precursor protein by the alpha -secretase enzyme.

Research Keywords
Aspirin as an antiplatelet drug for cardioprotection. New therapies for subarachnoid hemorrhage Lipid modification of Amyloid Beta in Alzheimer's disease Platelets in the pathophysiology and treatment of cardiovascular disease.
Clinical Research Keywords
aspirin, subarachnoid hemorrhage, cyclooxygenase in cancer, platelet function
Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews B, Milne GL, Harris BK, Hoeksema MD, Knowllmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA. Inhibition of the biosynthesis of prostaglandin E2 by low dose aspirin: implications for adenocarcinoma metastasis. Cancer Prev Res (Phila) [print-electronic]. 2016 Aug 8/23/2016; PMID: 27554763, PII: 1940-6207.CAPR-16-0094, DOI: 10.1158/1940-6207.CAPR-16-0094, ISSN: 1940-6215.

Tu W, Decker BS, He Z, Erdel BL, Eckert GJ, Hellman RN, Murray MD, Oates JA, Pratt JH. Triamterene Enhances the Blood Pressure Lowering Effect of Hydrochlorothiazide in Patients with Hypertension. J Gen Intern Med. 2016 Jan; 31(1): 30-6. PMID: 26194642, PMCID: PMC4700022, PII: 10.1007/s11606-015-3469-1, DOI: 10.1007/s11606-015-3469-1, ISSN: 1525-1497.

Zagol-Ikapite I, Sosa IR, Oram D, Judd A, Amarnath K, Amarnath V, Stec D, Oates JA, Boutaud O. Modification of platelet proteins by malondialdehyde: prevention by dicarbonyl scavengers. J. Lipid Res [print-electronic]. 2015 Nov; 56(11): 2196-205. PMID: 26378094, PMCID: PMC4617406, PII: jlr.P063271, DOI: 10.1194/jlr.P063271, ISSN: 1539-7262.

Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ, Ware LB, . Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. Crit. Care Med. 2015 Mar; 43(3): 534-41. PMID: 25474535, PMCID: PMC4336619, DOI: 10.1097/CCM.0000000000000718, ISSN: 1530-0293.

Shuck SC, Wauchope OR, Rose KL, Kingsley PJ, Rouzer CA, Shell SM, Sugitani N, Chazin WJ, Zagol-Ikapitte I, Boutaud O, Oates JA, Galligan JJ, Beavers WN, Marnett LJ. Protein modification by adenine propenal. Chem. Res. Toxicol [print-electronic]. 2014 Oct 10/20/2014; 27(10): 1732-42. PMID: 25211669, PMCID: PMC4203390, DOI: 10.1021/tx500218g, ISSN: 1520-5010.

Carrier EJ, Zagol-Ikapitte I, Amarnath V, Boutaud O, Oates JA. Levuglandin forms adducts with histone h4 in a cyclooxygenase-2-dependent manner, altering its interaction with DNA. Biochemistry [print-electronic]. 2014 Apr 4/22/2014; 53(15): 2436-41. PMID: 24684440, PMCID: PMC4004227, DOI: 10.1021/bi401673b, ISSN: 1520-4995.

Kawai VK, Avalos I, Oeser A, Oates JA, Milne GL, Solus JF, Chung CP, Stein CM. Suboptimal inhibition of platelet cyclooxygenase 1 by aspirin in systemic lupus erythematosus: association with metabolic syndrome. Arthritis Care Res (Hoboken). 2014 Feb; 66(2): 285-92. PMID: 24022862, PMCID: PMC3946810, DOI: 10.1002/acr.22169, ISSN: 2151-4658.

Shchepin RV, Liu W, Yin H, Zagol-Ikapitte I, Amin T, Jeong BS, Roberts LJ, Oates JA, Porter NA, Boutaud O. Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues. ACS Med Chem Lett. 2013 Aug 8/8/2013; 4(8): 710-4. PMID: 24482730, PMCID: PMC3904457, DOI: 10.1021/ml4000904, ISSN: 1948-5875.

Yin H, Vergeade A, Shi Q, Zackert WE, Gruenberg KC, Bokiej M, Amin T, Ying W, Masterson TS, Zinkel SS, Oates JA, Boutaud O, Roberts LJ. Acetaminophen inhibits cytochrome c redox cycling induced lipid peroxidation. Biochem. Biophys. Res. Commun [print-electronic]. 2012 Jun 6/29/2012; 423(2): 224-8. PMID: 22634010, PMCID: PMC3389218, PII: S0006-291X(12)00935-7, DOI: 10.1016/j.bbrc.2012.05.058, ISSN: 1090-2104.

Smith JP, Haddad EV, Taylor MB, Oram D, Blakemore D, Chen Q, Boutaud O, Oates JA. Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. Hypertension [print-electronic]. 2012 Mar; 59(3): 719-25. PMID: 22311905, PMCID: PMC3418792, PII: HYPERTENSIONAHA.111.181404, DOI: 10.1161/HYPERTENSIONAHA.111.181404, ISSN: 1524-4563.

Duggan KC, Hermanson DJ, Musee J, Prusakiewicz JJ, Scheib JL, Carter BD, Banerjee S, Oates JA, Marnett LJ. (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. Nat. Chem. Biol. 2011 Nov; 7(11): 803-9. PMID: 22053353, PMCID: PMC3298755, ISSN: 1552-4469.

Oates JA. Cardiovascular risk markers and mechanisms in targeting the COX pathway for colorectal cancer prevention. Cancer Prev Res (Phila). 2011 Aug; 4(8): 1145-8. PMID: 21816843, PII: 4/8/1145, DOI: 10.1158/1940-6207.CAPR-11-0333, ISSN: 1940-6215.

Chacon A, Zagol-Ikapitte I, Amarnath V, Reyzer ML, Oates JA, Caprioli RM, Boutaud O. On-tissue chemical derivatization of 3-methoxysalicylamine for MALDI-imaging mass spectrometry. J Mass Spectrom. 2011 Aug; 46(8): 840-6. PMID: 21834023, PMCID: PMC3174490, DOI: 10.1002/jms.1958, ISSN: 1096-9888.

Zagol-Ikapitte I, Amarnath V, Jadhav S, Oates JA, Boutaud O. Determination of 3-methoxysalicylamine levels in mouse plasma and tissue by liquid chromatography-tandem mass spectrometry: application to in vivo pharmacokinetics studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci [print-electronic]. 2011 May 5/1/2011; 879(15-16): 1098-104. PMID: 21489890, PMCID: PMC3091354, PII: S1570-0232(11)00183-8, DOI: 10.1016/j.jchromb.2011.03.026, ISSN: 1873-376X.

Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O. Functional characterization of mutations in inherited human cPLA2 deficiency. Biochemistry [print-electronic]. 2011 Mar 3/15/2011; 50(10): 1731-8. PMID: 21247147, PMCID: PMC3051024, DOI: 10.1021/bi101877n, ISSN: 1520-4995.

Duggan KC, Walters MJ, Musee J, Harp JM, Kiefer JR, Oates JA, Marnett LJ. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J. Biol. Chem [print-electronic]. 2010 Nov 11/5/2010; 285(45): 34950-9. PMID: 20810665, PMCID: PMC2966109, PII: M110.162982, DOI: 10.1074/jbc.M110.162982, ISSN: 1083-351X.

Zagol-Ikapitte IA, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts LJ, Davies SS. Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent ¿-Ketoaldehyde Scavenger, by LC/MS/MS. Pharmaceutics. 2010 Mar; 2(1): 18-29. PMID: 21822464, PMCID: PMC3150493, DOI: 10.3390/pharmaceutics2010018, ISSN: 1999-4923.

Boutaud O, Moore KP, Reeder BJ, Harry D, Howie AJ, Wang S, Carney CK, Masterson TS, Amin T, Wright DW, Wilson MT, Oates JA, Roberts LJ. Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2010 Feb 2/9/2010; 107(6): 2699-704. PMID: 20133658, PMCID: PMC2823910, PII: 0910174107, DOI: 10.1073/pnas.0910174107, ISSN: 1091-6490.

Ong DS, Lakhani V, Oates JA, O'Day DM. Kindred with prominent corneal nerves associated with a mutation in codon 804 of RET on chromosome 10q11. Arch. Ophthalmol. 2010 Feb; 128(2): 247-9. PMID: 20142552, PII: 128/2/247, DOI: 10.1001/archophthalmol.2009.389, ISSN: 1538-3601.

Zagol-Ikapitte I, Amarnath V, Bala M, Roberts LJ, Oates JA, Boutaud O. Characterization of scavengers of gamma-ketoaldehydes that do not inhibit prostaglandin biosynthesis. Chem. Res. Toxicol. 2010 Jan; 23(1): 240-50. PMID: 20041722, PMCID: PMC2831641, DOI: 10.1021/tx900407a, ISSN: 1520-5010.

Boutaud O, Oates JA. Study of inhibitors of the PGH synthases for which potency is regulated by the redox state of the enzymes. Methods Mol. Biol. 2010; 644: 67-90. PMID: 20645166, DOI: 10.1007/978-1-59745-364-6_7, ISSN: 1940-6029.

Nam TG, Nara SJ, Zagol-Ikapitte I, Cooper T, Valgimigli L, Oates JA, Porter NA, Boutaud O, Pratt DA. Pyridine and pyrimidine analogs of acetaminophen as inhibitors of lipid peroxidation and cyclooxygenase and lipoxygenase catalysis. Org. Biomol. Chem [print-electronic]. 2009 Dec 12/21/2009; 7(24): 5103-12. PMID: 20024105, PMCID: PMC2873786, DOI: 10.1039/b912528k, ISSN: 1477-0539.

Carrier EJ, Amarnath V, Oates JA, Boutaud O. Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin. Biochemistry. 2009 Nov 11/17/2009; 48(45): 10775-81. PMID: 19824699, PMCID: PMC2824920, DOI: 10.1021/bi9015132, ISSN: 1520-4995.

Adler DH, Phillips JA, Cogan JD, Iverson TM, Schnetz-Boutaud N, Stein JA, Brenner DA, Milne GL, Morrow JD, Boutaud O, Oates JA. The enteropathy of prostaglandin deficiency. J. Gastroenterol [print-electronic]. 2009; 44 Suppl 19: 1-7. PMID: 19148786, PMCID: PMC2799331, DOI: 10.1007/s00535-008-2253-y, ISSN: 0944-1174.

Babaev VR, Chew JD, Ding L, Davis S, Breyer MD, Breyer RM, Oates JA, Fazio S, Linton MF. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab. 2008 Dec; 8(6): 492-501. PMID: 19041765, PMCID: PMC2614698, PII: S1550-4131(08)00289-1, DOI: 10.1016/j.cmet.2008.09.005, ISSN: 1932-7420.

Hebert PR, Coffey CS, Byrne DW, Scott TA, Fagard RH, Rottman JN, Murray KT, Oates JA. Treatment of elderly hypertensive patients with epithelial sodium channel inhibitors combined with a thiazide diuretic reduces coronary mortality and sudden cardiac death. J Am Soc Hypertens. 2008 Sep; 2(5): 355-65. PMID: 19727429, PMCID: PMC2633478, DOI: 10.1016/j.jash.2008.04.001, ISSN: 1933-1711.

Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA, Brenner DA, Morrow JD, Boutaud O, Oates JA. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J. Clin. Invest. 2008 Jun; 118(6): 2121-31. PMID: 18451993, PMCID: PMC2350426, DOI: 10.1172/JCI30473, ISSN: 0021-9738.

Jackson AL, Oates JA. A patient with adult erythermalgia: evidence suggesting an autoimmune etiology. Am. J. Med. Sci. 2008 Apr; 335(4): 320-2. PMID: 18414074, PMCID: PMC3418791, PII: 00000441-200804000-00016, DOI: 10.1097/MAJ.0b013e31812f65e7, ISSN: 0002-9629.

Bala M, Chin CN, Logan AT, Amin T, Marnett LJ, Boutaud O, Oates JA. Acetylation of prostaglandin H2 synthases by aspirin is inhibited by redox cycling of the peroxidase. Biochem. Pharmacol [print-electronic]. 2008 Apr 4/1/2008; 75(7): 1472-81. PMID: 18242581, PMCID: PMC2693035, PII: S0006-2952(07)00818-0, DOI: 10.1016/j.bcp.2007.12.005, ISSN: 1873-2968.

Roberts LJ, Oates JA, Linton MF, Fazio S, Meador BP, Gross MD, Shyr Y, Morrow JD. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic. Biol. Med [print-electronic]. 2007 Nov 11/15/2007; 43(10): 1388-93. PMID: 17936185, PMCID: PMC2072864, PII: S0891-5849(07)00455-8, DOI: 10.1016/j.freeradbiomed.2007.06.019, ISSN: 0891-5849.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity. Biochemistry [print-electronic]. 2006 Dec 12/26/2006; 45(51): 15756-67. PMID: 17176098, PMCID: PMC2597444, DOI: 10.1021/bi061860g, ISSN: 1520-4995.

Boutaud O, Montine TJ, Chang L, Klein WL, Oates JA. PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. J. Neurochem [print-electronic]. 2006 Feb; 96(4): 917-23. PMID: 16412101, PMCID: PMC1621054, PII: JNC3586, DOI: 10.1111/j.1471-4159.2005.03586.x, ISSN: 0022-3042.

Burleigh ME, Babaev VR, Yancey PG, Major AS, McCaleb JL, Oates JA, Morrow JD, Fazio S, Linton MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. J. Mol. Cell. Cardiol. 2005 Sep; 39(3): 443-52. PMID: 16040051, PII: S0022-2828(05)00195-1, DOI: 10.1016/j.yjmcc.2005.06.011, ISSN: 0022-2828.

McAdam BF, Byrne D, Morrow JD, Oates JA. Contribution of cyclooxygenase-2 to elevated biosynthesis of thromboxane A2 and prostacyclin in cigarette smokers. Circulation [print-electronic]. 2005 Aug 8/16/2005; 112(7): 1024-9. PMID: 16087791, PII: CIRCULATIONAHA.105.542696, DOI: 10.1161/CIRCULATIONAHA.105.542696, ISSN: 1524-4539.

Zagol-Ikapitte I, Masterson TS, Amarnath V, Montine TJ, Andreasson KI, Boutaud O, Oates JA. Prostaglandin H(2)-derived adducts of proteins correlate with Alzheimer's disease severity. J. Neurochem [print-electronic]. 2005 Aug; 94(4): 1140-5. PMID: 15992375, PII: JNC3264, DOI: 10.1111/j.1471-4159.2005.03264.x, ISSN: 0022-3042.

Burleigh ME, Babaev VR, Patel MB, Crews BC, Remmel RP, Morrow JD, Oates JA, Marnett LJ, Fazio S, Linton MF. Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice. Biochem. Pharmacol. 2005 Aug 8/1/2005; 70(3): 334-42. PMID: 15950196, PII: S0006-2952(05)00285-6, DOI: 10.1016/j.bcp.2005.04.044, ISSN: 0006-2952.

Smith LH, Petrie MS, Morrow JD, Oates JA, Vaughan DE. The sterol response element binding protein regulates cyclooxygenase-2 gene expression in endothelial cells. J. Lipid Res [print-electronic]. 2005 May; 46(5): 862-71. PMID: 15716578, PII: M500021-JLR200, DOI: 10.1194/jlr.M500021-JLR200, ISSN: 0022-2275.

Boutaud O, Andreasson KI, Zagol-Ikapitte I, Oates JA. Cyclooxygenase-dependent lipid-modification of brain proteins. Brain Pathol. 2005 Apr; 15(2): 139-42. PMID: 15912886, ISSN: 1015-6305.

Murphey LJ, Williams MK, Sanchez SC, Byrne LM, Csiki I, Oates JA, Johnson DH, Morrow JD. Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Anal. Biochem. 2004 Nov 11/15/2004; 334(2): 266-75. PMID: 15494133, PII: S0003-2697(04)00682-7, DOI: 10.1016/j.ab.2004.08.019, ISSN: 0003-2697.

Zagol-Ikapitte I, Bernoud-Hubac N, Amarnath V, Roberts LJ, Boutaud O, Oates JA. Characterization of bis(levuglandinyl) urea derivatives as products of the reaction between prostaglandin H2 and arginine. Biochemistry. 2004 May 5/11/2004; 43(18): 5503-10. PMID: 15122916, DOI: 10.1021/bi049842r, ISSN: 0006-2960.

Brame CJ, Boutaud O, Davies SS, Yang T, Oates JA, Roden D, Roberts LJ. Modification of proteins by isoketal-containing oxidized phospholipids. J. Biol. Chem [print-electronic]. 2004 Apr 4/2/2004; 279(14): 13447-51. PMID: 14715668, PII: M313349200, DOI: 10.1074/jbc.M313349200, ISSN: 0021-9258.

Tang YW, Johnson JE, Browning PJ, Cruz-Gervis RA, Davis A, Graham BS, Brigham KL, Oates JA, Loyd JE, Stecenko AA. Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Microbiol. 2003 Jun; 41(6): 2633-40. PMID: 12791891, PMCID: PMC156536, ISSN: 0095-1137.

Boutaud O, Li J, Zagol I, Shipp EA, Davies SS, Roberts LJ, Oates JA. Levuglandinyl adducts of proteins are formed via a prostaglandin H2 synthase-dependent pathway after platelet activation. J. Biol. Chem [print-electronic]. 2003 May 5/9/2003; 278(19): 16926-8. PMID: 12637576, PII: M300940200, DOI: 10.1074/jbc.M300940200, ISSN: 0021-9258.

Sawaoka H, Dixon DA, Oates JA, Boutaud O. Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. J. Biol. Chem [print-electronic]. 2003 Apr 4/18/2003; 278(16): 13928-35. PMID: 12578839, PII: M300016200, DOI: 10.1074/jbc.M300016200, ISSN: 0021-9258.

Aronoff DM, Boutaud O, Marnett LJ, Oates JA. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes. J. Pharmacol. Exp. Ther. 2003 Feb; 304(2): 589-95. PMID: 12538810, DOI: 10.1124/jpet.102.042853, ISSN: 0022-3565.

Boutaud O, Dixon DA, Oates JA, Sawaoka H. Tristetraprolin binds to the COX-2 mRNA 3' untranslated region in cancer cells. Adv. Exp. Med. Biol. 2003; 525: 157-60. PMID: 12751757, ISSN: 0065-2598.

Cox B, Murphey LJ, Zackert WE, Chinery R, Graves-Deal R, Boutaud O, Oates JA, Coffey RJ, Morrow JD. Human colorectal cancer cells efficiently conjugate the cyclopentenone prostaglandin, prostaglandin J(2), to glutathione. Biochim. Biophys. Acta. 2002 Sep 9/5/2002; 1584(1): 37-45. PMID: 12213491, PII: S1388198102002676, ISSN: 0006-3002.

Boutaud O, Ou JJ, Chaurand P, Caprioli RM, Montine TJ, Oates JA. Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. J. Neurochem. 2002 Aug; 82(4): 1003-6. PMID: 12358806, PII: 1064, ISSN: 0022-3042.

Smith LH, Boutaud O, Breyer M, Morrow JD, Oates JA, Vaughan DE. Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro. Arterioscler. Thromb. Vasc. Biol. 2002 Jun 6/1/2002; 22(6): 983-8. PMID: 12067908, ISSN: 1524-4636.

Boutaud O, Aronoff DM, Richardson JH, Marnett LJ, Oates JA. Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc. Natl. Acad. Sci. U.S.A. 2002 May 5/14/2002; 99(10): 7130-5. PMID: 12011469, PMCID: PMC124540, PII: 99/10/7130, DOI: 10.1073/pnas.102588199, ISSN: 0027-8424.

Burleigh ME, Babaev VR, Oates JA, Harris RC, Gautam S, Riendeau D, Marnett LJ, Morrow JD, Fazio S, Linton MF. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation. 2002 Apr 4/16/2002; 105(15): 1816-23. PMID: 11956125, ISSN: 1524-4539.

Nakayama T, Soma M, Watanabe Y, Hasimu B, Sato M, Aoi N, Kosuge K, Kanmatsuse K, Kokubun S, Morrow JD, Oates JA. Splicing mutation of the prostacyclin synthase gene in a family associates with hypertension. Biochem biophys res Commun. 2002; 297((5)): 1135-9.

Sheller J, Dworski R, Hagaman D, Oates J, Murray J. The prostaglandin E agonist, misoprostol, inhibits airway IL-5 production in atopic asthmatics. Prostaglandins Other Lipid Mediat. 2002; 70((1-2)): 185-93.

Boutaud O, Brame CJ, Chaurand P, Li J, Rowlinson SW, Crews BC, Ji C, Marnett LJ, Caprioli RM, Roberts LJ, Oates JA. Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry. 2001 Jun 6/12/2001; 40(23): 6948-55. PMID: 11389610, PII: bi002629k, ISSN: 0006-2960.

Boutaud O, Li J, Chaurand P, Brame CJ, Marnett LJ, Roberts LJ, Oates JA. Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv. Exp. Med. Biol. 2001; 500: 133-7. PMID: 11764925, ISSN: 0065-2598.

Hartert TV, Dworski RT, Mellen BG, Oates JA, Murray JJ, Sheller JR. Prostaglandin E(2) decreases allergen-stimulated release of prostaglandin D(2) in airways of subjects with asthma. Am. J. Respir. Crit. Care Med. 2000 Aug; 162(2 Pt 1): 637-40. PMID: 10934099, DOI: 10.1164/ajrccm.162.2.9904038, ISSN: 1073-449X.

Murphey LJ, Hachey DL, Oates JA, Morrow JD, Brown NJ. Metabolism of bradykinin In vivo in humans: identification of BK1-5 as a stable plasma peptide metabolite. J. Pharmacol. Exp. Ther. 2000 Jul; 294(1): 263-9. PMID: 10871321, ISSN: 0022-3565.

Sheller JR, Mitchell D, Meyrick B, Oates J, Breyer R. EP2 receptor mediates bronchodilation by PGE2 in mice. J Appl Physiol. 2000; 88: 2214-8.

Tellioglu T, Oates JA, Biaggioni I. Muchausen's syndrome presenting as a baroreflex failure. N Engl J Med. 2000; 343((8)): 581.

Dworski R, Murray JJ, Roberts LJ, Oates JA, Morrow JD, Fisher L, Sheller JR. Allergen-induced synthesis of F(2)-isoprostanes in atopic asthmatics. Evidence for oxidant stress. Am. J. Respir. Crit. Care Med. 1999 Dec; 160(6): 1947-51. PMID: 10588611, DOI: 10.1164/ajrccm.160.6.9903064, ISSN: 1073-449X.

Boutaud O, Brame CJ, Salomon RG, Roberts LJ, Oates JA. Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway. Biochemistry. 1999 Jul 7/20/1999; 38(29): 9389-96. PMID: 10413514, PII: bi990470+, DOI: 10.1021/bi990470+, ISSN: 0006-2960.

Morrow JD, Oates JA, Roberts LJ, Zackert WE, Mitchell TA, Lazarus G, Guzzo C. Increased formation of thromboxane in vivo in humans with mastocytosis. J. Invest. Dermatol. 1999 Jul; 113(1): 93-7. PMID: 10417625, PII: jid624, DOI: 10.1046/j.1523-1747.1999.00624.x, ISSN: 0022-202X.

Goldstein RE, O'Neill JA, Holcomb GW, Morgan WM, Neblett WW, Oates JA, Brown N, Nadeau J, Smith B, Page DL, Abumrad NN, Scott HW. Clinical experience over 48 years with pheochromocytoma. Ann. Surg. 1999 Jun; 229(6): 755-64; discussion 764. PMID: 10363888, PMCID: PMC1420821, ISSN: 0003-4932.

Chinery R, Coffey RJ, Graves-Deal R, Kirkland SC, Sanchez SC, Zackert WE, Oates JA, Morrow JD. Prostaglandin J2 and 15-deoxy-delta12,14-prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. Cancer Res. 1999 Jun 6/1/1999; 59(11): 2739-46. PMID: 10364000, ISSN: 0008-5472.

Morrow JD, Zackert WE, Yang JP, Kurhts EH, Callewaert D, Dworski R, Kanai K, Taber D, Moore K, Oates JA, Roberts LJ. Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 1999 May 5/1/1999; 269(2): 326-31. PMID: 10222005, PII: S0003-2697(99)94008-3, DOI: 10.1006/abio.1999.4008, ISSN: 0003-2697.

Kennedy CR, Zhang Y, Brandon S, Guan Y, Coffee K, Funk CD, Magnuson MA, Oates JA, Breyer MD, Breyer RM. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Nat. Med. 1999 Feb; 5(2): 217-20. PMID: 9930871, DOI: 10.1038/5583, ISSN: 1078-8956.

Boutaud, Olivier, Brame, Cynthia J., Salomon, Robert G., Roberts II, Jackson, and Oates, John A. Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglanding pathway. 1999.

Chinery, Rebecca, Coffey, Robert J., Graves-Deal Ramona, Kirkland, Susan C., Sanchez, Stephanie E., Zackert, William, E., Oates, John, Morrow, Jason D. Prostaglandin J2 and 15-deoxy-delta 12, 14- prostaglandin J2 induce proliferation of cyclooxygenase-depleted colorectal cancer cells. 1999.

Kennedy, Christopher RJ., Zhang, Yahua, Brandon, Suzanne, Guan, Youfei, Coffee, Keith, Funk, Colin D., Magnuson, Mark A., Oates, John, Breyer, Matthew D., and Breyer, Richard M. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. 1999.

Denney WD, Kemp WE, Anthony LB, Oates JA, Byrd BF. Echocardiographic and biochemical evaluation of the development and progression of carcinoid heart disease. J. Am. Coll. Cardiol. 1998 Oct; 32(4): 1017-22. PMID: 9768727, PII: S0735-1097(98)00354-4, ISSN: 0735-1097.

Dworski RT, Funk CD, Oates JA, Sheller JR. Prednisone increases PGH-synthase 2 in atopic humans in vivo. Am. J. Respir. Crit. Care Med. 1997 Jan; 155(1): 351-7. PMID: 9001335, DOI: 10.1164/ajrccm.155.1.9001335, ISSN: 1073-449X.

Roberts LJ, Moore KP, Zackert WE, Oates JA, Morrow JD. Identification of the major urinary metabolite of the F2-isoprostane 8-iso-prostaglandin F2alpha in humans. J. Biol. Chem. 1996 Aug 8/23/1996; 271(34): 20617-20. PMID: 8702808, ISSN: 0021-9258.

Murray JJ, Mullins MD, Knapp HR, Keller SL, Serafin WE, Roberts LJ, Struthers BJ, Oates JA. Regulation of the Immune Response by Eicosanoids: Pharmacology and Clinical Effects of Prostaglandin E in Aspirin-Sensitive Syndromes. Am J Ther. 1995 Oct; 2(10): 739-48. PMID: 11854780, ISSN: 1536-3686.

Oates JA. Introduction: Misoprostol and Eicosanoid Symposium. Am J Ther. 1995 Sep; 2(9): 591-4. PMID: 11854831, ISSN: 1536-3686.

Anthony LB, May ME, Oates JA. Case report: lanreotide in the management of hypercalcemia of malignancy. Am. J. Med. Sci. 1995 Jun; 309(6): 312-4. PMID: 7771500, ISSN: 0002-9629.

Morrow JD, Guzzo C, Lazarus G, Oates JA, Roberts LJ. Improved diagnosis of mastocytosis by measurement of the major urinary metabolite of prostaglandin D2. J. Invest. Dermatol. 1995 Jun; 104(6): 937-40. PMID: 7769262, PII: 0022202X9500067U, ISSN: 0022-202X.

Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, Strauss WE, Oates JA, Roberts LJ. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N. Engl. J. Med. 1995 May 5/4/1995; 332(18): 1198-203. PMID: 7700313, DOI: 10.1056/NEJM199505043321804, ISSN: 0028-4793.

Morrow, J.D., Frei, B., Longmire, A.W., Gaziano, J.M., Lynch, S.M., Shyr, Y., Strauss, W.E., Oates, J.A., Roberts, L.J., II. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers: Smoking as a cause of oxidative damage. 1995.

Dworski, R., Fitzgerald, G.A., Oates, J.A., Sheller, J.R. Effect of oral prednisone on airway inflammatory mediators in atopic asthma. 1994.

Morrow JD, Awad JA, Oates JA, Roberts LJ. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J. Invest. Dermatol. 1992 May; 98(5): 812-5. PMID: 1373750, ISSN: 0022-202X.

Mosqueda-Garcia R, Oates JA, Appalsamy M, Robertson D. Administration of carbamazepine in the nucleus of the solitary tract inhibits the antihypertensive effect of clonidine. Eur. J. Pharmacol. 1991 May 5/17/1991; 197(2-3): 213-6. PMID: 1915569, PII: 0014-2999(91)90524-T, ISSN: 0014-2999.

Legrand AB, Lawson JA, Meyrick BO, Blair IA, Oates JA. Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway. J. Biol. Chem. 1991 Apr 4/25/1991; 266(12): 7570-7. PMID: 1850411, ISSN: 0021-9258.

Roberts LJ, Oates JA. Biochemical diagnosis of systemic mast cell disorders. J. Invest. Dermatol. 1991 Mar; 96(3): 19S-24S; discussion 24S. PMID: 2002247, ISSN: 0022-202X.

Roberts LJ, Oates JA. Biochemical diagnosis of systemic mast cell disorders. J. Invest. Dermatol. 1991 Mar; 96(3 Suppl): 19S-24S; discussion 24S. PMID: 16799604, PII: 5612609, DOI: 10.1111/1523-1747.ep12468945, ISSN: 1523-1747.

Morrow JD, Prakash C, Awad JA, Duckworth TA, Zackert WE, Blair IA, Oates JA, Roberts LJ. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 1991 Feb 2/15/1991; 193(1): 142-8. PMID: 2042739, ISSN: 0003-2697.

Morrow JD, Prakash C, Duckworth TA, Zackert WE, Blair IA, Oates JA, Roberts LJ. A stable isotope dilution mass spectrometric assay for the major urinary metabolite of PGD2. Adv. Prostaglandin Thromboxane Leukot. Res. 1991; 21A: 315-8. PMID: 1825560, ISSN: 0732-8141.

Sebaldt RJ, Sheller JR, Oates JA, Roberts LJ, FitzGerald GA. Inhibition of eicosanoid biosynthesis by glucocorticoids in humans. Proc. Natl. Acad. Sci. U.S.A. 1990 Sep; 87(18): 6974-8. PMID: 2169616, PMCID: PMC54664, ISSN: 0027-8424.

Smith S, Anthony L, Roberts LJ, Oates JA, Pincus T. Resolution of musculoskeletal symptoms in the carcinoid syndrome after treatment with the somatostatin analog octreotide. Ann. Intern. Med. 1990 Jan 1/1/1990; 112(1): 66-8. PMID: 2293820, ISSN: 0003-4819.

Murray JJ, Nowak J, Oates JA, FitzGerald GA. Platelet-vessel wall interactions in individuals who smoke cigarettes. Adv. Exp. Med. Biol. 1990; 273: 189-98. PMID: 2288276, ISSN: 0065-2598.

Oates JA. The Jeremiah Metzger lecture. Participation of eicosanoids in the syndromes of myocardial ischemia. Trans. Am. Clin. Climatol. Assoc. 1990; 101: 154-60. PMID: 2486439, PMCID: PMC2376512, ISSN: 0065-7778.

Brash AR, Yokoyama C, Oates JA, Yamamoto S. Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase. Arch. Biochem. Biophys. 1989 Sep; 273(2): 414-22. PMID: 2774560, ISSN: 0003-9861.

Oates JA. Aspirin in the prevention of catastrophes of the coronary circulation. Adv. Prostaglandin Thromboxane Leukot. Res. 1989; 19: 57-63. PMID: 2526539, ISSN: 0732-8141.

Dworski R, Sheller JR, Wickersham NE, Oates JA, Brigham KL, Roberts LJ, Fitzgerald GA. Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition. Am. Rev. Respir. Dis. 1989 Jan; 139(1): 46-51. PMID: 2492175, DOI: 10.1164/ajrccm/139.1.46, ISSN: 0003-0805.

Oates JA, FitzGerald GA, Branch RA, Jackson EK, Knapp HR, Roberts LJ. Clinical implications of prostaglandin and thromboxane A2 formation (2). N. Engl. J. Med. 1988 Sep 9/22/1988; 319(12): 761-7. PMID: 3045551, DOI: 10.1056/NEJM198809223191206, ISSN: 0028-4793.

Oates JA, FitzGerald GA, Branch RA, Jackson EK, Knapp HR, Roberts LJ. Clinical implications of prostaglandin and thromboxane A2 formation (1). N. Engl. J. Med. 1988 Sep 9/15/1988; 319(11): 689-98. PMID: 3045550, DOI: 10.1056/NEJM198809153191106, ISSN: 0028-4793.

Parris WC, Oates JA, Kambam J, Shmerling R, Sawyers JF. Pre-treatment with somatostatin in the anaesthetic management of a patient with carcinoid syndrome. Can J Anaesth. 1988 Jul; 35(4): 413-6. PMID: 2900085, DOI: 10.1007/BF03010865, ISSN: 0832-610X.

Brigham KL, Serafin W, Zadoff A, Blair I, Meyrick B, Oates JA. Prostaglandin E2 attenuation of sheep lung responses to endotoxin. J. Appl. Physiol. 1988 Jun; 64(6): 2568-74. PMID: 2841275, ISSN: 8750-7587.

Bruch JS, Stein RS, Oates JA. Hypertension complicating essential thrombocythemia. Am. J. Med. Sci. 1988 May; 295(5): 466-8. PMID: 3376989, ISSN: 0002-9629.

Oates JA. Antagonism of antihypertensive drug therapy by nonsteroidal anti-inflammatory drugs. Hypertension. 1988 Mar; 11(3 Pt 2): II4-6. PMID: 3280491, ISSN: 0194-911X.

FitzGerald GA, Oates JA, Nowak J. Cigarette smoking and hemostatic function. Am. Heart J. 1988 Jan; 115(1 Pt 2): 267-71. PMID: 3276116, ISSN: 0002-8703.

Nowak J, Murray JJ, FitzGerald GA, Wehr CJ, Hammon JW, Oates JA. Eicosanoids and sudden cardiac death. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17A: 20-4. PMID: 2959048, ISSN: 0732-8141.

Brash AR, Oates JA, Yokoyama C, Yamamoto S. Mechanism of transformation of 15(S)-hydroperoxyeicosatetraenoic acid to 15-series leukotrienes by purified porcine leukocyte 12-lipoxygenase. Adv. Prostaglandin Thromboxane Leukot. Res. 1987; 17A: 75-7. PMID: 2821770, ISSN: 0732-8141.

Scott HW, Parris WC, Sandidge PC, Oates JA, Roberts LJ. Hazards in operative management of patients with systemic mastocytosis. Ann. Surg. 1983 May; 197(5): 507-14. PMID: 6189461, PMCID: PMC1353019, ISSN: 0003-4932.

Scott HW, Dean RH, Lea JW, Waterhouse G, Sussman C, Robertson D, Oates JA. Surgical experience with retrogastric and retropancreatic pheochromocytomas. Surgery. 1982 Nov; 92(5): 853-65. PMID: 6753206, ISSN: 0039-6060.

Scott HW, Reynolds V, Green N, Page D, Oates JA, Robertson D, Roberts S. Clinical experience with malignant pheochromocytomas. Surg Gynecol Obstet. 1982 Jun; 154(6): 801-18. PMID: 7079921, ISSN: 0039-6087.

Dean RH, Oates JA, Wilson JP, Rhamy RK, Hollifield JW, Burko H, Foster JH. Bilateral renal artery stenosis and renovascular hypertension. Surgery. 1977 Jan; 81(1): 53-60; discussion 60. PMID: 16977747, ISSN: 0039-6060.

Scott HW, Oates JA, Nies AS, Burko H, Page DL, Rhamy RK. Pheochromocytoma: present diagnosis and management. Ann. Surg. 1976 May; 183(5): 587-93. PMID: 1275597, PMCID: PMC1344352, ISSN: 0003-4932.

Tannenbaum J, Splawinski JA, Oates JA, Nies AS. Enhanced renal prostaglandin production in the dog, I: Effects on renal function. Cir res. 1975; 36((1)): 197-203.

Chang LCT, Splawinski JA, Oates JA, Nies AS. Enhanced renal prostaglandin production in the dog, II: Effects on intra-renal hemodynamics. Circ Res. 1975; 36((1)): 204-7.

Danon A, Heimberg M, Oates JA. Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors. Biochimica et Biophys Acta. 1975; 388((3)): 318-30.

Danon A, Chang LCT, Sweetman BJ, Nies AS, Oates JA. Synthesis of prostaglandins by the rat renal papilla in vitro: Mechanism of stimulation by angiotensin II. Biochimica et Biophys Acta. 1975; 388((1)): 71-83.

Frolich JC, Wilson TW, Sweetman BJ, Smigel M, Nies AS, Carr K, Watson JT, Oates JA. Urinary Prostaglandins: Identification and origin. J Clin Invest. 1975; 55((4)): 763-70.

Hengstmann JH, Falkner FC, Watson JT, Oates JA. Quantitative determination of guanethidine and other guanido-containg drugs in biological fluids by gas chromatography with flame ionization detection and multiple ion detection. Analytical Chemistry. 1974; 46: 35-9.

Frolich JC, Wilson TW, Smigel M, Oates JA. A competitive protein binding assay specific for prostaglandin E. Biochimica et Biophys Acta. 1974; 348((2)): 241-48.

Fann WE, Davis JM, Janowsky DS, Kaufmann JS, Cavanaugh JH, Oates JA. Effect of antidepressant and antimanicc drugs on amine uptake in man. J Nerv & Mental Disease. 1974; 158((5)): 361-8.

Shand DG, Morgan DH, Oates JA. The release of guanethidine and bethanidine by splenic nerve stimulation: A quantitative evaluation showing dissociation from adrenergic blockade. J Pharmacol Exp Ther. 1973; 184((1)): 73-80.

Bieck PR, Oates JA, Robison GA, Adkins RB. Cyclic AMP in the regulation of gastric secretion in dogs and humans. Am J Physiol. 1973; 224((1)): 158-64.

Rangno RE, Kaufmann JS, Cavanaugh JH, Island D, Watson JT, Oates JA. Effects of a false neurotransmitter, p-hydroxynorephedrine, on the function of adrenergic neurons in hypertensive patients. J Clin Invest. 1973; 52((4)): 952-60.

Splawinski JA, Nies AS, Sweetman B, Oates JA. The effects of arachidonic acid, prostaglandin E2 and prostaglandin F2α on the longitudinal stomach strip of the rat. J Pharmacol Exp Ther. 1973; 187((3)): 501-10.

Sweetman BJ, Watson JT, Carr K, Oates JA, Frolich JC. Quantitative vapor-phase analysis of prostaglandin F2α in female human urine. Prostaglandins. 1973; 3((3)): 385-87.

Watson JT, Pelster DR, Sweetman BJ, Frolich JC, Oates JA. Display-oriented data system for multiple ion detection with gas chromatography-mass spectrometry in quantifying biomedically important compunds. Analytical Chemistry. 1973; 45((12)): 2071-78.

Fann WE, Davis JM, Janowsky DS, Cavanaugh JH, Kaufmann JS, Griffith JD, Oates JA. Effects of lithium on adrenergic function in man. Clin Pharmacol Ther. 1972; 13((1)): 71-7.

Fann WE, Davis JM, Janowsky DS, Kaufmann JS, Griffith JD, Oates JA. Effect of iprindole on amine uptake in man. Arch Gen Psychiatry. 1972; 26((2)): 158-62.

Griffith JD, Cavanaugh J, Held J, Oates JA. Dextroamphetamine: Evaluation of psychotominetic properties in man. Arch Gen Psychiatry. 1972; 26((2)): 97-100.

Klatte EC, Babb OW, Burko H, Foster JH, Rhamy RK, Oates JA. The roentgenographic pre and postoperative assessment of patients with renovascular disease. Am J Roentgenol Radium Ther Nucl Med. 1972; 114((4)): 696-709.

McAllister RG Jr, Michelakis AM, Oates JA, Foster JH. Malignant hypertension due to renal artery stenosis. Greater renin release from the nonstenotic kidney. JAMA. 1972; 221((8)): 865-68.

Gerber N, Lynn R, Oates JA. Acute intoxication with 5,5-diphenyl-hydantoin (Dilantin) associated with impairment of biotransformation. Ann Intern Med. 1972; 77: 765-71.

McAllister RG Jr, Van Way CW III, Dayani K, Anderson WJ, Temple E, Michelakis AM, Coppage WS Jr, Oates JA. Malignant hypertension:Effect of therapy on renin and aldosterone. Circ Res Suppl. 1971; 28((5)).

Shand DG, Cavanaugh JH, Oates JA. The fate of SU-13197, a new antiarrhythmic drug, in rat and man. Clin Pharmacol Ther. 1971; 12((5)): 769-78.

Fan WE, Janowsky DS, Davis JM, Oates JA. Chlorpromazine reversal of the antihypertensive action of quanethidine. Lancet. 1971; 2((721)): 436-7.

Shand DG, Oates JA. Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs. Biochem pharmacol. 1971; 20((7)): 1720-23.

Shand DG, Sell CG, Oates JA. Hypertrophic obstructive cardiomyopathy in an infant:Propranolol therapy for 3 years. N Engl J med. 1971; 285((15)): 843-44.

Effects on transport of biogenic amines in man. Psychopharmacologica. 1971; 22((2)): 111-25.

Klatte EC, Worrell JA, Foster JH, Phamy RK, Burko H, Michelakis AM, Oates JA. Diagnostic criteria of bilateral renovascular hypertension. Radiology. 1971; 101((2)): 301-4.

Mitchell JR, Oates JA. Guanethidine and related agents:I. Mechanism of the selective blockade of adrenergic neurons and its antagonism by drugs. J Pharmacology & Experimental Therapeutics. 1970; 172: 100-7.

Mitchell JR, Cavanaugh JH, Dingell JV, Oates JA. Guanethidine and related agents: II. Metabolism by hepatic microsomes and its inhibition by drugs. J Pharmacology & Experimental Therapeutics. 1970; 172: 108-14.

Mitchell JR, Cavanaugh JH, Arias L, Oates JA. Guanethidine and related agents: III. Antagonism by drugs which inhibit the norepinephrine pump in man. J Clin Invest. 1970; 49((8)): 1596-604.

Shand DG, Nuckolls EM, Oates JA. Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther. 1970; 11: 112-20.

Cavanaugh JH, Griffith JD, Oates JA. Effect of amphetamine on the pressor response to tyramine:Formation of p-hydroxynorephedrine from amphetamine in man. Clin Pharmacol Ther. 1970; 11((5)): 656-64.

Flegin OT, Morgan DH, Oates JA, Shand DG. The mechanism of the reversal of the effect of quanethidine by amphetamines in cat and man. Br J Pharm. 1970; 39: 253P-254P.

Morgan DH, Oates JA, Shand DG. Evidence that quanethidine does not block adrenergic nerves by acting as a false transmitter. Br J pharmacol. 1970; 39((1)): 186P-187P.

Foster JH, Phamy RK, Oates JA, Klatte EC, Burko HC, Michelakis AM. Renovascular hypertension secondary to atherosclerosis. Am J Med. 1969; 46((5)): 741-50.

Foster JH, Rhamy RK, Oates JA, Klatte EC, Burko HC, Michelakis AM. Hypertension and fibromuscular dysplasia of the renal arteries. Surgery. 1969; 65: 157-81.

Van Way CW, Anderson WJ, Michelaskis AM, Manlove A, Oates JA. The role of renin in coarctation of the aorta. Surg Forum. 1969; 20: 207-9.

Oates JA, Fann WE, Cavanaugh JH. Effect of doxepin on the norepinephrine pump. Psychosomatics. 1969; 10((3)): 12-3.

DesPrez RM, Oates JA. Lack of relationship of febrile response to endotoxin and brain stem 5-hydroxytryptamine. Proc Soc Exp Biol Med. 1968; 127: 793-4.

Pettinger WA, Soyangco FG, Oates JA. Inhibition of monoamine oxidase in man by furazolidone. Clin Pharmacol Therap. 1968; 9: 442-7.

Pettinger WA, OatesJA. Supersensitivity to tyramine during monoamine oxidase inhibition in man. Clin Pharmacol Therap. 1968; 9: 341-4.

Malmquist J, Oates JA. Effects of adrenergic neuron-blocking quanidine derivatives on mitochondrial metabolism. Biochem Pharmacol. 1968; 17((9)): 1845-54.

Zachariae H, malmquist J, Oates JA, Pettinger W. Studies on mechanism of kinin formation in inflammation. J Physiol. 1967; 190: 81-90.

Mitchell JR, Arias L, Oates JA. Antagonism of the antihypertensive action of quanethidine sulfate by desipramine hydrochloride. JAMA. 1967; 202((10)): 973-6.

Oates JA, Pettinger WA, Doctor RB. Evidence for the release of bradykinin in carcinoid syndrome. J Clin Invest. 1966; 45((2)): 173-8.

Zachariae H, Oates JA. Effect of pH on an experimental kinin forming system in rat subcutaneous tissue. J Invest Dermatol. 1966; 47: 493-6.

Foster JH, Oates JA, Rhamy RK, Klatte EC, Pettinger WA, Burko H, Younger RK, Scott HW Jr. Detection and treatment of patients with renovascular hypertension. Surgery. 1966; 60: 240-52.

Foster JH, Pettinger WA, Oates JA, Rhamy RK, Klatte EC, Burko HC, Bolasny BL, Gordon RD, Puyau FA, Younger BS. Malignant hypertension secondary to renal artery stenosis in children. Ann Surgery. 1966; 164((4)): 700-13.

DesPrez R, Helman R, Oates JA. Inhibition of endotoxin fever by reserpine. Proc Soc Exp Biol and Med. 1966; 122: 746-9.

Zachariae H, Malmquist J, Oates JA. Kininase in himan polymorphonuclear leukocytes. Life Sciences. 1966; 5: 2347-55.

Melmon KL, Sjoerdsma A, Oates JA, Laster L. Treatment of malabsorption and diarrhea of the carcinoid sundrome with methysergide. Gastroenterology. 1965; 48((1)): 18.

Oates JA, Seligmann AW, Clark MA, Rousseau P, Lee RE. The relative efficacy of quanethidine, methylodopa and pargyline as antihypertensive agents. N Engl J Med. 1965; 273((14)): 729-34.

Hodge JV, Oates JA, Sjoerdsma A. Reduction of the central effects of tryptophan by a decarboxylase inhibitor. Clin Pharmacol Ther. 1964; 5((2)): 149-55.

Oates JA, Melmon K, Sjoerdsma A, Gillespie L, Mason DT. Release of a kinin peptide in the carcinoid syndrome. Lancet. 1964; 1((1)): 514-17.

Melmon KL, Rivlin R, Oates JA, Sjoerdsma A. Further studies of plasma tyrosine in patients with altered thyroid function. J Clin Endocrinol and Metab. 1964; 24((8)): 691-8.

Oates JA, Nirenberg PA, Jepson JB, Sjoerdsma A, Udenfriend S. Conversation of phenylalamine to phenethylamine in patients with phenylketonuria. Proc Soc Exp Biol Med. 1963; 112: 1078.

Oates JA, Sjoerdsma A. A unique syndrome associated with secretion of 5-hydroxytryptophan by metastatic gastric carcinoids. Am J Med. 1962; 32: 333.

Oates JA, Marsh EB, Sjoerdsma A. Studies on histamine in himan urine using a fluorometric method of assay. Clin Chem Acta. 1962; 7: 488.

Gillespie L, Oates JA, Crout JR, Sjoerdsma A. Clinical and chemical studies with α-methyldopa in patients with hypertension. Circulation. 1962; 25: 281.

Levine RJ, Oates JA, Vendsalu A, Sjoerdsma A. Studies on the metabolism of aromatic amines in relation to altered thyroid function in man. J Clin Endocrinol Metab. 1962; 22: 1242.

Oates JA, Sjoerdsma A. Metabolism of 5-hydroxy-D-and L-tryptophan in man:Synthesis of serotonin from the D-isomer. Proc Soc Exp Biol Med. 1961; 108: 264.

Pisano JJ, Oates JA, Karmen A, Sjoerdsma A, Udenfriend S. Identification of P-hydroxy-α-(methylaminomethyl) benzyl alcohol (synephrine) in human urine. J Biol Chem. 1961; 236: 898.

Sjoerdsma A, Oates JA, Gillespie L. Quantification of monoamine oxidase inhibition produced by various drugs in man. Proc Soc Exp Biol Med. 1960; 103: 485.

Oates JA, Gillespie L, Udenfriend S, Sjoerdsma. Amino acid decarboxylase inhibition and blood pressure reduction in man by α-methyldopa. Science. 1960; 131: 1890-91.

Sjoerdsma A, Oates JA, Zaltzman P, Udenfriend S. Serotonin synthesis in carcinoid patients: Its inhibition by α-methyldopa with measurement of associated increases in urinary 5-hydroxytryptophan. New Engl J Med. 1960; 263: 585.

Oates JA, Sjoerdsma A. Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor. Neurology. 1960; 10((12)): 1076-78.

Jepson JB, Lovenberg W, Zaltzman P, Oates JA, Sjoerdsma A, Udenfriend S. Amine metabolism studies in normal and phenylketonuric humans by monoamine oxidase inhibition. Biochem J. 1960; 74: 5P.

Sjoerdsma A, Oates JA, Zaltzman P, Udenfriend S. Identification and assay of urinary tryptamine: Application as an index of monamine oxidase inhibition in man. JPET. 1959; 126:: 217.

Sjoerdsma A, Lovenberg W, Oates JA, Crout JR, Udenfriend S. Alterations in the pattern of amine excretion in man produced by a monamine oxidase inhibitor. Science. 1959; 130: 225.

Artom C, Lofland HB, Oates JA. In vivo incorporation of diethanolamine into liver lipids. J Biol Chem. 1958; 233: 833.

Available Postdoctoral Position Details
Posted: 3/21/2011
Post-doctoral position in translational research, oriented to clinical investigation based on mechanistic hypotheses. Areas include optimization of the use of aspirin as a cardioprotective agent, investigation of the function of platelets in cardiovascular disease, basic biology of the platelet, Alzheimer|s disease, and development of new therapy for subarachnoid hemorrhage.