Roy Zent, M.B.B.Ch., Ph.D.

C-3210 MCN
TN 2372

The laboratory works on the basic role of integrins in epithelial cell biology. We utilize the kidney as a model system and perform biochemical techniques, cell biology and transgenic mice to understand the basic mechanisms whereby integrin-ECM interactions modify cell function. In addition, in collaboration with Dr. Charles Sanders, we perform structural functions on integrins utilizing NMR.

Integrin biology, Kidney, Signal transduction, Branching morphogenesis,Kidney,Mouse

Sucre JM, Bock F, Negretti NM, Benjamin JT, Gulleman PM, Dong X, Ferguson KT, Jetter CS, Han W, Liu Y, Kook S, Gokey JJ, Guttentag SH, Kropski JA, Blackwell TS, Zent R, Plosa EJ. Alveolar repair following LPS-induced injury requires cell-ECM interactions. JCI Insight. 2023 Jul 7/24/2023; 8(14): PMID: 37279065, PII: 167211, DOI: 10.1172/jci.insight.167211, ISSN: 2379-3708.

Zuchowski Y, Carty J, Terker AS, Bock F, Trapani JB, Bhave G, Watts JA, Keller S, Zhang M, Zent R, Harris RC, Arroyo JP. Insulin-regulated aminopeptidase is required for water excretion in response to acute hypotonic stress. Am J Physiol Renal Physiol [print-electronic]. 2023 Jun 6/1/2023; 324(6): F521-F531-F531. PMID: 36995926, PMCID: PMC10202483, DOI: 10.1152/ajprenal.00318.2022, ISSN: 1522-1466.

Chew E, Barnado A, Ikizler TA, Zent R, Frech T. Evaluation of hypertension in systemic sclerosis and systemic lupus erythematosus overlap. J Scleroderma Relat Disord [print-electronic]. 2023 Feb; 8(1): 14-9. PMID: 36743818, PMCID: PMC9896192, PII: 10.1177_23971983221122673, DOI: 10.1177/23971983221122673, ISSN: 2397-1991.

Hunter K, Larsen JA, Love HD, Evans RC, Roy S, Zent R, Harris RC, Wilson MH, Fissell WH. Inhibition of Transforming Growth Factor-ß Improves Primary Renal Tubule Cell Differentiation in Long-Term Culture. Tissue Eng Part A [print-electronic]. 2023 Feb; 29(3-4): 102-11. PMID: 36274231, PMCID: PMC10081716, DOI: 10.1089/ten.TEA.2022.0147, ISSN: 1937-335X.

Arroyo JP, Terker AS, Zuchowski Y, Watts JA, Bock F, Meyer C, Luo W, Kapp ME, Gould ER, Miranda AX, Carty J, Jiang M, Vanacore RM, Hammock E, Wilson MH, Zent R, Zhang M, Bhave G, Harris RC. Kidney collecting duct cells make vasopressin in response to NaCl-induced hypertonicity. JCI Insight. 2022 Dec 12/22/2022; 7(24): PMID: 36326835, PMCID: PMC9869977, PII: 161765, DOI: 10.1172/jci.insight.161765, ISSN: 2379-3708.

Xie Q, Zhang M, Mao X, Xu M, Liu S, Shang D, Xu Y, Chen R, Guan Y, Huang X, Zent R, Pozzi A, Hao CM. Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury. Cell Death Dis. 2022 Dec 12/15/2022; 13(12): 1044. PMID: 36522320, PMCID: PMC9755308, PII: 10.1038/s41419-022-05496-z, DOI: 10.1038/s41419-022-05496-z, ISSN: 2041-4889.

Taguchi K, Elias BC, Sugahara S, Sant S, Freedman BS, Waikar SS, Pozzi A, Zent R, Harris RC, Parikh SM, Brooks CR. Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation. J Clin Invest. 2022 Dec 12/1/2022; 132(23): PMID: 36453545, PMCID: PMC9711881, PII: 158096, DOI: 10.1172/JCI158096, ISSN: 1558-8238.

Maré IA, Kramer B, Hazelhurst S, Nhlapho MD, Zent R, Harris PA, Klipin M. Electronic Data Capture System (REDCap) for Health Care Research and Training in a Resource-Constrained Environment: Technology Adoption Case Study. JMIR Med Inform. 2022 Aug 8/30/2022; 10(8): e33402. PMID: 36040763, PMCID: PMC9472062, PII: v10i8e33402, DOI: 10.2196/33402, ISSN: 2291-9694.

Haake SM, Plosa EJ, Kropski JA, Venton LA, Reddy A, Bock F, Chang BT, Luna AJ, Nabukhotna K, Xu ZQ, Prather RA, Lee S, Tanjore H, Polosukhin VV, Viquez OM, Jones A, Luo W, Wilson MH, Rathmell WK, Massion PP, Pozzi A, Blackwell TS, Zent R. Ligand-independent integrin ß1 signaling supports lung adenocarcinoma development. JCI Insight. 2022 Aug 8/8/2022; 7(15): PMID: 35763345, PMCID: PMC9462485, PII: 154098, DOI: 10.1172/jci.insight.154098, ISSN: 2379-3708.

Noll NA, Riley LA, Moore CS, Zhong L, Bersi MR, West JD, Zent R, Merryman WD. Loss of talin in cardiac fibroblasts results in augmented ventricular cardiomyocyte hypertrophy in response to pressure overload. Am J Physiol Heart Circ Physiol [print-electronic]. 2022 May 5/1/2022; 322(5): H857-H866-H866. PMID: 35333120, PMCID: PMC9018049, DOI: 10.1152/ajpheart.00632.2021, ISSN: 1522-1539.

Borza CM, Bolas G, Bock F, Zhang X, Akabogu FC, Zhang MZ, de Caestecker M, Yang M, Yang H, Lee E, Gewin L, Fogo AB, McDonald WH, Zent R, Pozzi A. DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3. JCI Insight. 2022 Feb 2/8/2022; 7(3): PMID: 34941574, PMCID: PMC8855801, PII: 150887, DOI: 10.1172/jci.insight.150887, ISSN: 2379-3708.

Morais MRPT, Tian P, Lawless C, Murtuza-Baker S, Hopkinson L, Woods S, Mironov A, Long DA, Gale DP, Zorn TMT, Kimber SJ, Zent R, Lennon R. Kidney organoids recapitulate human basement membrane assembly in health and disease. Elife. 2022 Jan 1/25/2022; 11: PMID: 35076391, PMCID: PMC8849328, PII: 73486, DOI: 10.7554/eLife.73486, ISSN: 2050-084X.

Borza CM, Bolas G, Zhang X, Browning Monroe MB, Zhang MZ, Meiler J, Skwark MJ, Harris RC, Lapierre LA, Goldenring JR, Hook M, Rivera J, Brown KL, Leitinger B, Tyska MJ, Moser M, Böttcher RT, Zent R, Pozzi A. The Collagen Receptor Discoidin Domain Receptor 1b Enhances Integrin ß1-Mediated Cell Migration by Interacting With Talin and Promoting Rac1 Activation. Front Cell Dev Biol. 2022; 10: 836797. PMID: 35309920, PMCID: PMC8928223, PII: 836797, DOI: 10.3389/fcell.2022.836797, ISSN: 2296-634X.

Yazlovitskaya EM, Plosa E, Bock F, Viquez OM, Mernaugh G, Gewin LS, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Blackwell TS, Pozzi A, Zent R. The laminin-binding integrins regulate nuclear factor ¿B-dependent epithelial cell polarity and inflammation. J Cell Sci [print-electronic]. 2021 Dec 12/15/2021; 134(24): PMID: 34841431, PMCID: PMC8729780, PII: 273835, DOI: 10.1242/jcs.259161, ISSN: 1477-9137.

Bock F, Elias BC, Dong X, Parekh DV, Mernaugh G, Viquez OM, Hassan A, Amara VR, Liu J, Brown KL, Terker AS, Chiusa M, Gewin LS, Fogo AB, Brakebusch CH, Pozzi A, Zent R. Rac1 promotes kidney collecting duct integrity by limiting actomyosin activity. J Cell Biol [print-electronic]. 2021 Nov 11/1/2021; 220(11): PMID: 34647970, PMCID: PMC8563289, PII: 212704, DOI: 10.1083/jcb.202103080, ISSN: 1540-8140.

Ghoshal K, Li X, Peng D, Falck JR, Anugu RR, Chiusa M, Stafford JM, Wasserman DH, Zent R, Luther JM, Pozzi A. EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance. Diabetes [print-electronic]. 2021 Oct 10/21/2021; PMID: 34957494, PII: 139089, DOI: 10.2337/db21-0298, ISSN: 1939-327X.

Ghoshal K, Li X, Peng D, Falck JR, Anugu RR, Chiusa M, Stafford JM, Wasserman DH, Zent R, Luther JM, Pozzi A. EET Analog Treatment Improves Insulin Signaling in a Genetic Mouse Model of Insulin Resistance. Diabetes [print-electronic]. 2021 Oct 10/21/2021; PMID: 34675004, PII: db21-0298, DOI: 10.2337/db21-0298, ISSN: 1939-327X.

Carter P, Schnell U, Chaney C, Tong B, Pan X, Ye J, Mernaugh G, Cotton JL, Margulis V, Mao J, Zent R, Evers BM, Kapur P, Carroll TJ. Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma. J Clin Invest. 2021 Jun 6/1/2021; 131(11): PMID: 34060480, PMCID: PMC8159698, PII: e144108, DOI: 10.1172/JCI144108, ISSN: 1558-8238.

Tiriveedhi V, Ivy MT, Myles EL, Zent R, Rathmell JC, Titze J. Ex Vivo High Salt Activated Tumor-Primed CD4+T Lymphocytes Exert a Potent Anti-Cancer Response. Cancers (Basel). 2021 Apr 4/2/2021; 13(7): PMID: 33918403, PMCID: PMC8038238, PII: cancers13071690, DOI: 10.3390/cancers13071690, ISSN: 2072-6694.

Kumar B, Ahmad R, Giannico GA, Zent R, Talmon GA, Harris RC, Clark PE, Lokeshwar V, Dhawan P, Singh AB. Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation. J Exp Clin Cancer Res. 2021 Feb 2/23/2021; 40(1): 77. PMID: 33622361, PMCID: PMC7901196, PII: 10.1186/s13046-021-01870-5, DOI: 10.1186/s13046-021-01870-5, ISSN: 1756-9966.

Masuzaki R, Ray KC, Roland J, Zent R, Lee YA, Karp SJ. Integrin ß1 Establishes Liver Microstructure and Modulates Transforming Growth Factor ß during Liver Development and Regeneration. Am J Pathol [print-electronic]. 2021 Feb; 191(2): 309-19. PMID: 33159885, PMCID: PMC7888191, PII: S0002-9440(20)30492-2, DOI: 10.1016/j.ajpath.2020.10.011, ISSN: 1525-2191.

Love H, Evans R, Humes HD, Roy S, Zent R, Harris R, Wilson M, Fissell WH. Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells. Tissue Eng Part A. 2020 Oct; 26(19-20): 1091-8. PMID: 32312181, PMCID: PMC7580646, DOI: 10.1089/ten.TEA.2019.0294, ISSN: 1937-335X.

Chiusa M, Hu W, Zienkiewicz J, Chen X, Zhang MZ, Harris RC, Vanacore RM, Bentz JA, Remuzzi G, Benigni A, Fogo AB, Luo W, Mili S, Wilson MH, Zent R, Hawiger J, Pozzi A. EGF receptor-mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling. J Cell Biol. 2020 Sep 9/7/2020; 219(9): PMID: 32678881, PMCID: PMC7480104, PII: 151955, DOI: 10.1083/jcb.202001120, ISSN: 1540-8140.

Randles MJ, Lausecker F, Humphries JD, Byron A, Clark SJ, Miner JH, Zent R, Humphries MJ, Lennon R. Basement membrane ligands initiate distinct signalling networks to direct cell shape. Matrix Biol [print-electronic]. 2020 Aug; 90: 61-78. PMID: 32147508, PMCID: PMC7327512, PII: S0945-053X(20)30024-X, DOI: 10.1016/j.matbio.2020.02.005, ISSN: 1569-1802.

Saraswati S, Lietman CD, Li B, Mathew S, Zent R, Young PP. Small proline-rich repeat 3 is a novel coordinator of PDGFRß and integrin ß1 crosstalk to augment proliferation and matrix synthesis by cardiac fibroblasts. FASEB J [print-electronic]. 2020 Jun; 34(6): 7885-904. PMID: 32297675, PMCID: PMC7302973, DOI: 10.1096/fj.201902815R, ISSN: 1530-6860.

Plosa EJ, Benjamin JT, Sucre JM, Gulleman PM, Gleaves LA, Han W, Kook S, Polosukhin VV, Haake SM, Guttentag SH, Young LR, Pozzi A, Blackwell TS, Zent R. ß1 Integrin regulates adult lung alveolar epithelial cell inflammation. JCI Insight. 2020 Jan 1/30/2020; 5(2): PMID: 31873073, PMCID: PMC7098727, PII: 129259, DOI: 10.1172/jci.insight.129259, ISSN: 2379-3708.

Babaer D, Zheng M, Ivy MT, Zent R, Tiriveedhi V. Methylselenol producing selenocompounds enhance the efficiency of mammaglobin-A peptide vaccination against breast cancer cells. Oncol Lett [print-electronic]. 2019 Dec; 18(6): 6891-8. PMID: 31807192, PMCID: PMC6876340, PII: OL-0-0-11010, DOI: 10.3892/ol.2019.11010, ISSN: 1792-1074.

Cruz-Acuña R, Mulero-Russe A, Clark AY, Zent R, García AJ. Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels. J Cell Sci. 2019 Oct 10/21/2019; 132(20): PMID: 31558679, PMCID: PMC6826008, PII: jcs.226639, DOI: 10.1242/jcs.226639, ISSN: 1477-9137.

Chiusa M, Hu W, Liao HJ, Su Y, Borza CM, de Caestecker MP, Skrypnyk NI, Fogo AB, Pedchenko V, Li X, Zhang MZ, Hudson BG, Basak T, Vanacore RM, Zent R, Pozzi A. The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus. J Am Soc Nephrol [print-electronic]. 2019 Sep; 30(9): 1605-24. PMID: 31383731, PMCID: PMC6727269, PII: ASN.2018111160, DOI: 10.1681/ASN.2018111160, ISSN: 1533-3450.

Babaer D, Amara S, McAdory BS, Johnson O, Myles EL, Zent R, Rathmell JC, Tiriveedhi V. Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells. Cancers (Basel). 2019 May 5/14/2019; 11(5): PMID: 31091800, PMCID: PMC6562487, PII: cancers11050672, DOI: 10.3390/cancers11050672, ISSN: 2072-6694.

Yazlovitskaya EM, Viquez OM, Tu T, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Pozzi A, Zent R. The laminin binding a3 and a6 integrins cooperate to promote epithelial cell adhesion and growth. Matrix Biol [print-electronic]. 2019 Apr; 77: 101-16. PMID: 30193894, PMCID: PMC6399080, PII: S0945-053X(18)30262-2, DOI: 10.1016/j.matbio.2018.08.010, ISSN: 1569-1802.

Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH. Energy Metabolism Couples Hepatocyte Integrin-linked Kinase to Liver Glucoregulation and the Postabsorptive Response of Mice in an Age-dependent Manner. Am. J. Physiol. Endocrinol. Metab [print-electronic]. 2019 Mar 3/5/2019; PMID: 30835508, DOI: 10.1152/ajpendo.00496.2018, ISSN: 1522-1555.

Xu D, Chen P, Wang B, Wang Y, Miao N, Yin F, Cheng Q, Zhou Z, Xie H, Zhou L, Liu J, Wang X, Zent R, Lu L, Zhang W. NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury. Am. J. Physiol. Renal Physiol [print-electronic]. 2019 Feb 2/1/2019; 316(2): F382-F395. PMID: 30207166, DOI: 10.1152/ajprenal.00360.2018, ISSN: 1522-1466.

Kramer B, Zent R. Diaspora linkages benefit both sides: a single partnership experience. Glob Health Action. 2019; 12(1): 1645558. PMID: 31362603, PMCID: PMC6711129, DOI: 10.1080/16549716.2019.1645558, ISSN: 1654-9880.

Love HD, Ao M, Jorgensen S, Swearingen L, Ferrell NJ, Evans RC, Gewin L, Harris RC, Zent R, Roy S, Fissell WH. Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture. Tissue Eng Part A [print-electronic]. 2018 Nov 11/28/2018; PMID: 30484388, DOI: 10.1089/ten.TEA.2018.0182, ISSN: 1937-335X.

Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT. LCP1 preferentially binds clasped aMß2 integrin and attenuates leukocyte adhesion under flow. J. Cell. Sci. 2018 Nov 11/21/2018; 131(22): PMID: 30333137, PMCID: PMC6262777, PII: jcs.218214, DOI: 10.1242/jcs.218214, ISSN: 1477-9137.

Sausville LN, Gangadhariah MH, Chiusa M, Mei S, Wei S, Zent R, Luther JM, Shuey MM, Capdevila JH, Falck JR, Guengerich FP, Williams SM, Pozzi A. The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production. Cancer Res [print-electronic]. 2018 Sep 9/1/2018; 78(17): 4865-77. PMID: 30012669, PMCID: PMC6125168, PII: 0008-5472.CAN-17-3977, DOI: 10.1158/0008-5472.CAN-17-3977, ISSN: 1538-7445.

Lausecker F, Tian X, Inoue K, Wang Z, Pedigo CE, Hassan H, Liu C, Zimmer M, Jinno S, Huckle AL, Hamidi H, Ross RS, Zent R, Ballestrem C, Lennon R, Ishibe S. Vinculin is required to maintain glomerular barrier integrity. Kidney Int [print-electronic]. 2018 Mar; 93(3): 643-55. PMID: 29241625, PMCID: PMC5846847, PII: S0085-2538(17)30771-8, DOI: 10.1016/j.kint.2017.09.021, ISSN: 1523-1755.

Flowers EM, Sudderth J, Zacharias L, Mernaugh G, Zent R, DeBerardinis RJ, Carroll TJ. Lkb1 deficiency confers glutamine dependency in polycystic kidney disease. Nat Commun. 2018 Feb 2/26/2018; 9(1): 814. PMID: 29483507, PMCID: PMC5827653, PII: 10.1038/s41467-018-03036-y, DOI: 10.1038/s41467-018-03036-y, ISSN: 2041-1723.

Brown KL, Banerjee S, Feigley A, Abe H, Blackwell TS, Pozzi A, Hudson BG, Zent R. Salt-bridge modulates differential calcium-mediated ligand binding to integrin a1- and a2-I domains. Sci Rep. 2018 Feb 2/13/2018; 8(1): 2916. PMID: 29440721, PMCID: PMC5811549, PII: 10.1038/s41598-018-21231-1, DOI: 10.1038/s41598-018-21231-1, ISSN: 2045-2322.

Cleghorn WM, Bulus N, Kook S, Gurevich VV, Zent R, Gurevich EV. Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of GPCRs. Cell. Signal [print-electronic]. 2018 Jan; 42: 259-69. PMID: 29133163, PMCID: PMC5732042, PII: S0898-6568(17)30290-5, DOI: 10.1016/j.cellsig.2017.11.003, ISSN: 1873-3913.

Deger SM, Hung AM, Gamboa JL, Siew ED, Ellis CD, Booker C, Sha F, Li H, Bian A, Stewart TG, Zent R, Mitch WE, Abumrad NN, Ikizler TA. Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients. JCI Insight. 2017 Nov 11/16/2017; 2(22): PMID: 29202452, PMCID: PMC5752392, PII: 95185, DOI: 10.1172/jci.insight.95185, ISSN: 2379-3708.

Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R. Talin regulates integrin ß1-dependent and -independent cell functions in ureteric bud development. Development [print-electronic]. 2017 Nov 11/15/2017; 144(22): 4148-58. PMID: 28993400, PMCID: PMC5719244, PII: dev.149914, DOI: 10.1242/dev.149914, ISSN: 1477-9129.

Böttcher RT, Veelders M, Rombaut P, Faix J, Theodosiou M, Stradal TE, Rottner K, Zent R, Herzog F, Fässler R. Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading. J. Cell Biol [print-electronic]. 2017 Nov 11/6/2017; 216(11): 3785-98. PMID: 28912124, PMCID: PMC5674885, PII: jcb.201701176, DOI: 10.1083/jcb.201701176, ISSN: 1540-8140.

Polosukhina D, Love HD, Moses HL, Lee E, Zent R, Clark PE. Pharmacologic Inhibition of ß-Catenin With Pyrvinium Inhibits Murine and Human Models of Wilms Tumor. Oncol. Res [print-electronic]. 2017 Nov 11/2/2017; 25(9): 1653-64. PMID: 28695795, PMCID: PMC5670010, DOI: 10.3727/096504017X14992942781895, ISSN: 1555-3906.

Starchenko A, Graves-Deal R, Yang YP, Li C, Zent R, Singh B, Coffey RJ. Clustering of integrin a5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells. Mol. Biol. Cell [print-electronic]. 2017 May 5/15/2017; 28(10): 1288-300. PMID: 28356422, PMCID: PMC5426844, PII: mbc.E16-12-0852, DOI: 10.1091/mbc.E16-12-0852, ISSN: 1939-4586.

Polosukhina D, Love HD, Correa H, Su Z, Dahlman KB, Pao W, Moses HL, Arteaga CL, Lovvorn HN, Zent R, Clark PE. Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors. Mol Oncol [print-electronic]. 2017 Apr; 11(4): 405-21. PMID: 28188683, PMCID: PMC5378659, DOI: 10.1002/1878-0261.12044, ISSN: 1878-0261.

Williams AS, Trefts E, Lantier L, Grueter CA, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH. Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance. Diabetes [print-electronic]. 2017 Feb; 66(2): 325-34. PMID: 27899483, PMCID: PMC5248997, PII: db16-0484, DOI: 10.2337/db16-0484, ISSN: 1939-327X.

Viquez OM, Yazlovitskaya EM, Tu T, Mernaugh G, Secades P, McKee KK, Georges-Labouesse E, De Arcangelis A, Quaranta V, Yurchenco P, Gewin LC, Sonnenberg A, Pozzi A, Zent R. Integrin alpha6 maintains the structural integrity of the kidney collecting system. Matrix Biol [print-electronic]. 2017 Jan; 57-58: 244-57. PMID: 28043890, PMCID: PMC5330664, PII: S0945-053X(16)30262-1, DOI: 10.1016/j.matbio.2016.12.003, ISSN: 1569-1802.

Borza CM, Su Y, Tran TL, Yu L, Steyns N, Temple KJ, Skwark MJ, Meiler J, Lindsley CW, Hicks BR, Leitinger B, Zent R, Pozzi A. Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis. Matrix Biol [print-electronic]. 2017 Jan; 57-58: 258-71. PMID: 27915093, PMCID: PMC5329129, PII: S0945-053X(16)30269-4, DOI: 10.1016/j.matbio.2016.11.009, ISSN: 1569-1802.

Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R. Implications of the differing roles of the ß1 and ß3 transmembrane and cytoplasmic domains for integrin function. Elife. 2016 Dec 12/8/2016; 5: PMID: 27929375, PMCID: PMC5207772, DOI: 10.7554/eLife.18633, ISSN: 2050-084X.

Gewin L, Zent R, Pozzi A. Progression of chronic kidney disease: too much cellular talk causes damage. Kidney Int [print-electronic]. 2016 Oct 10/20/2016; PMID: 27773427, PII: S0085-2538(16)30473-2, DOI: 10.1016/j.kint.2016.08.025, ISSN: 1523-1755.

Kang L, Mokshagundam S, Reuter B, Lark DS, Sneddon CC, Hennayake C, Williams AS, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH. Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice. Diabetes [print-electronic]. 2016 Jun; 65(6): 1590-600. PMID: 27207548, PMCID: PMC4878430, PII: db15-1434, DOI: 10.2337/db15-1434, ISSN: 1939-327X.

Haake SM, Li J, Bai Y, Kinose F, Fang B, Welsh EA, Zent R, Dhillon J, Pow-Sang JM, Chen YA, Koomen JM, Rathmell WK, Fishman M, Haura EB. Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics. Clin. Cancer Res [print-electronic]. 2016 May 5/24/2016; PMID: 27220961, PII: 1078-0432.CCR-15-1673, DOI: 10.1158/1078-0432.CCR-15-1673, ISSN: 1078-0432.

Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, Stothers C, Ero-Tolliver IA, McCall AS, Vanacore R, Bhave G, Santoro S, Blackwell TS, Zent R, Pozzi A, Hudson BG. Extracellular chloride signals collagen IV network assembly during basement membrane formation. J. Cell Biol. 2016 May 5/23/2016; 213(4): 479-94. PMID: 27216258, PMCID: PMC4878091, PII: jcb.201510065, DOI: 10.1083/jcb.201510065, ISSN: 1540-8140.

Nlandu Khodo S, Neelisetty S, Woodbury L, Green E, Harris RC, Zent R, Gewin L. Deleting the TGF-ß receptor in proximal tubules impairs HGF signaling. Am. J. Physiol. Renal Physiol [print-electronic]. 2016 Mar 3/15/2016; 310(6): F499-510. PMID: 26739889, PMCID: PMC4796273, PII: ajprenal.00446.2015, DOI: 10.1152/ajprenal.00446.2015, ISSN: 1522-1466.

Theodosiou M, Widmaier M, Böttcher RT, Rognoni E, Veelders M, Bharadwaj M, Lambacher A, Austen K, Müller DJ, Zent R, Fässler R. Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. Elife. 2016 Jan 1/27/2016; 5: e10130. PMID: 26821125, PMCID: PMC4749545, DOI: 10.7554/eLife.10130, ISSN: 2050-084X.

Atherton P, Stutchbury B, Wang DY, Jethwa D, Tsang R, Meiler-Rodriguez E, Wang P, Bate N, Zent R, Barsukov IL, Goult BT, Critchley DR, Ballestrem C. Vinculin controls talin engagement with the actomyosin machinery. Nat Commun. 2015 Dec 12/4/2015; 6: 10038. PMID: 26634421, PMCID: PMC4686655, PII: ncomms10038, DOI: 10.1038/ncomms10038, ISSN: 2041-1723.

Yi Y, Polosukhina D, Love HD, Hembd A, Pickup M, Moses HL, Lovvorn HN, Zent R, Clark PE. A Murine Model of K-RAS and ß-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor. J. Urol [print-electronic]. 2015 Dec; 194(6): 1762-70. PMID: 25934441, PII: S0022-5347(15)03890-2, DOI: 10.1016/j.juro.2015.04.090, ISSN: 1527-3792.

Austen K, Ringer P, Mehlich A, Chrostek-Grashoff A, Kluger C, Klingner C, Sabass B, Zent R, Rief M, Grashoff C. Extracellular rigidity sensing by talin isoform-specific mechanical linkages. Nat. Cell Biol [print-electronic]. 2015 Dec; 17(12): 1597-606. PMID: 26523364, PMCID: PMC4662888, PII: ncb3268, DOI: 10.1038/ncb3268, ISSN: 1476-4679.

Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R. Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development. J. Cell. Sci [print-electronic]. 2015 Dec 12/1/2015; 128(23): 4293-305. PMID: 26490995, PMCID: PMC4712811, PII: jcs.164509, DOI: 10.1242/jcs.164509, ISSN: 1477-9137.

Neelisetty S, Alford C, Reynolds K, Woodbury L, Nlandu-Khodo S, Yang H, Fogo AB, Hao CM, Harris RC, Zent R, Gewin L. Renal fibrosis is not reduced by blocking transforming growth factor-ß signaling in matrix-producing interstitial cells. Kidney Int [print-electronic]. 2015 Sep; 88(3): 503-14. PMID: 25760325, PMCID: PMC4556568, PII: ki201551, DOI: 10.1038/ki.2015.51, ISSN: 1523-1755.

Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jiménez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E. Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell. Microbiol [print-electronic]. 2015 Aug; 17(8): 1179-204. PMID: 25678064, DOI: 10.1111/cmi.12429, ISSN: 1462-5822.

Yazlovitskaya EM, Tseng HY, Viquez O, Tu T, Mernaugh G, McKee KK, Riggins K, Quaranta V, Pathak A, Carter BD, Yurchenco P, Sonnenberg A, Böttcher RT, Pozzi A, Zent R. Integrin a3ß1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol. Biol. Cell [print-electronic]. 2015 May 5/15/2015; 26(10): 1857-74. PMID: 25808491, PMCID: PMC4436831, PII: mbc.E14-07-1203, DOI: 10.1091/mbc.E14-07-1203, ISSN: 1939-4586.

Wang H, Chen X, Su Y, Paueksakon P, Hu W, Zhang MZ, Harris RC, Blackwell TS, Zent R, Pozzi A. P47(phox) contributes to albuminuria and kidney fibrosis in mice. Kidney Int [print-electronic]. 2015 May; 87(5): 948-62. PMID: 25565313, PMCID: PMC4425591, PII: ki2014386, DOI: 10.1038/ki.2014.386, ISSN: 1523-1755.

Karaköse E, Geiger T, Flynn K, Lorenz-Baath K, Zent R, Mann M, Fässler R. The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites. J. Cell. Sci [print-electronic]. 2015 Mar 3/1/2015; 128(5): 1023-33. PMID: 25609703, PMCID: PMC4342583, PII: jcs.162545, DOI: 10.1242/jcs.162545, ISSN: 1477-9137.

Gangadhariah MH, Luther JM, Garcia V, Paueksakon P, Zhang MZ, Hayward SW, Love HD, Falck JR, Manthati VL, Imig JD, Schwartzman ML, Zent R, Capdevila JH, Pozzi A. Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. J. Am. Soc. Nephrol [print-electronic]. 2015 Mar; 26(3): 597-610. PMID: 25071086, PMCID: PMC4341468, PII: ASN.2013090980, DOI: 10.1681/ASN.2013090980, ISSN: 1533-3450.

Cleghorn WM, Branch KM, Kook S, Arnette C, Bulus N, Zent R, Kaverina I, Gurevich EV, Weaver AM, Gurevich VV. Arrestins regulate cell spreading and motility via focal adhesion dynamics. Mol. Biol. Cell [print-electronic]. 2015 Feb 2/15/2015; 26(4): 622-35. PMID: 25540425, PMCID: PMC4325834, PII: mbc.E14-02-0740, DOI: 10.1091/mbc.E14-02-0740, ISSN: 1939-4586.

Borza CM, Chen X, Zent R, Pozzi A. Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View. Curr Top Membr. 2015; 76: 231-53. PMID: 26610916, PMCID: PMC4913201, PII: S1063-5823(15)00061-7, DOI: 10.1016/bs.ctm.2015.07.003, ISSN: 1063-5823.

Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R. Epithelial ß1 integrin is required for lung branching morphogenesis and alveolarization. Development [print-electronic]. 2014 Dec; 141(24): 4751-62. PMID: 25395457, PMCID: PMC4299273, PII: dev.117200, DOI: 10.1242/dev.117200, ISSN: 1477-9129.

Miller CG, Pozzi A, Zent R, Schwarzbauer JE. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol. Biol. Cell [print-electronic]. 2014 Aug 8/15/2014; 25(16): 2342-50. PMID: 24943838, PMCID: PMC4142608, PII: mbc.E14-03-0800, DOI: 10.1091/mbc.E14-03-0800, ISSN: 1939-4586.

Bryan L, Ibrahim T, Zent R, Fischer MJ. The kidney research predicament. J. Am. Soc. Nephrol [print-electronic]. 2014 May; 25(5): 898-903. PMID: 24652790, PMCID: PMC4005318, PII: ASN.2013121313, DOI: 10.1681/ASN.2013121313, ISSN: 1533-3450.

Byron A, Randles MJ, Humphries JD, Mironov A, Hamidi H, Harris S, Mathieson PW, Saleem MA, Satchell SC, Zent R, Humphries MJ, Lennon R. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. J. Am. Soc. Nephrol [print-electronic]. 2014 May; 25(5): 953-66. PMID: 24436469, PMCID: PMC4005312, PII: ASN.2013070795, DOI: 10.1681/ASN.2013070795, ISSN: 1533-3450.

Lennon R, Byron A, Humphries JD, Randles MJ, Carisey A, Murphy S, Knight D, Brenchley PE, Zent R, Humphries MJ. Global analysis reveals the complexity of the human glomerular extracellular matrix. J. Am. Soc. Nephrol [print-electronic]. 2014 May; 25(5): 939-51. PMID: 24436468, PMCID: PMC4005295, PII: ASN.2013030233, DOI: 10.1681/ASN.2013030233, ISSN: 1533-3450.

Skrypnyk N, Chen X, Hu W, Su Y, Mont S, Yang S, Gangadhariah M, Wei S, Falck JR, Jat JL, Zent R, Capdevila JH, Pozzi A. PPARa activation can help prevent and treat non-small cell lung cancer. Cancer Res [print-electronic]. 2014 Jan 1/15/2014; 74(2): 621-31. PMID: 24302581, PMCID: PMC3902646, PII: 0008-5472.CAN-13-1928, DOI: 10.1158/0008-5472.CAN-13-1928, ISSN: 1538-7445.

Lee K, Boyd KL, Parekh DV, Kehl-Fie TE, Baldwin HS, Brakebusch C, Skaar EP, Boothby M, Zent R. Cdc42 promotes host defenses against fatal infection. Infect. Immun [print-electronic]. 2013 Aug; 81(8): 2714-23. PMID: 23690402, PMCID: PMC3719566, PII: IAI.01114-12, DOI: 10.1128/IAI.01114-12, ISSN: 1098-5522.

Moik D, Böttcher A, Makhina T, Grashoff C, Bulus N, Zent R, Fässler R. Mutations in the paxillin-binding site of integrin-linked kinase (ILK) destabilize the pseudokinase domain and cause embryonic lethality in mice. J. Biol. Chem [print-electronic]. 2013 Jun 6/28/2013; 288(26): 18863-71. PMID: 23658024, PMCID: PMC3696662, PII: M113.470476, DOI: 10.1074/jbc.M113.470476, ISSN: 1083-351X.

Pozzi A, Zent R. Integrins in kidney disease. J. Am. Soc. Nephrol [print-electronic]. 2013 Jun; 24(7): 1034-9. PMID: 23641054, PMCID: PMC3699832, PII: ASN.2013010012, DOI: 10.1681/ASN.2013010012, ISSN: 1533-3450.

Natarajan C, Hata AN, Hamm HE, Zent R, Breyer RM. Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor. Mol. Pharmacol [print-electronic]. 2013 Jan; 83(1): 206-16. PMID: 23087260, PMCID: PMC3533480, PII: mol.112.080473, DOI: 10.1124/mol.112.080473, ISSN: 1521-0111.

Gewin L, Vadivelu S, Neelisetty S, Srichai MB, Paueksakon P, Pozzi A, Harris RC, Zent R. Deleting the TGF-ß receptor attenuates acute proximal tubule injury. J. Am. Soc. Nephrol [print-electronic]. 2012 Dec; 23(12): 2001-11. PMID: 23160515, PMCID: PMC3507360, PII: ASN.2012020139, DOI: 10.1681/ASN.2012020139, ISSN: 1533-3450.

Bartlett CS, Boyd KL, Harris RC, Zent R, Breyer RM. EP1 disruption attenuates end-organ damage in a mouse model of hypertension. Hypertension [print-electronic]. 2012 Nov; 60(5): 1184-91. PMID: 23006735, PMCID: PMC3478772, PII: HYPERTENSIONAHA.112.199026, DOI: 10.1161/HYPERTENSIONAHA.112.199026, ISSN: 1524-4563.

Plosa EJ, Gooding KA, Zent R, Prince LS. Nonmuscle myosin II regulation of lung epithelial morphology. Dev. Dyn [print-electronic]. 2012 Nov; 241(11): 1770-81. PMID: 22972683, PMCID: PMC3484380, DOI: 10.1002/dvdy.23866, ISSN: 1097-0177.

Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A. Enhancing integrin a1 inserted (I) domain affinity to ligand potentiates integrin a1ß1-mediated down-regulation of collagen synthesis. J. Biol. Chem [print-electronic]. 2012 Oct 10/12/2012; 287(42): 35139-52. PMID: 22888006, PMCID: PMC3471707, PII: M112.358648, DOI: 10.1074/jbc.M112.358648, ISSN: 1083-351X.

Mathew S, Lu Z, Palamuttam RJ, Mernaugh G, Hadziselimovic A, Chen J, Bulus N, Gewin LS, Voehler M, Meves A, Ballestrem C, Fässler R, Pozzi A, Sanders CR, Zent R. ß1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. Mol. Cell. Biol [print-electronic]. 2012 Oct; 32(20): 4080-91. PMID: 22869523, PMCID: PMC3457338, PII: MCB.00568-12, DOI: 10.1128/MCB.00568-12, ISSN: 1098-5549.

Zent R, Pozzi A. Connecting the segments [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2012 Oct; 23(10): 1603-5. PMID: 22975669, PII: ASN.2012080850, DOI: 10.1681/ASN.2012080850, ISSN: 1533-3450.

Mathew S, Chen X, Pozzi A, Zent R. Integrins in renal development. Pediatr. Nephrol [print-electronic]. 2012 Jun; 27(6): 891-900. PMID: 21603909, DOI: 10.1007/s00467-011-1890-1, ISSN: 1432-198X.

Yu L, Su Y, Paueksakon P, Cheng H, Chen X, Wang H, Harris RC, Zent R, Pozzi A. Integrin a1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int [print-electronic]. 2012 Jun; 81(11): 1086-97. PMID: 22297672, PMCID: PMC3345314, PII: ki2011474, DOI: 10.1038/ki.2011.474, ISSN: 1523-1755.

Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A. Inhibition of integrin a2ß1 ameliorates glomerular injury. J. Am. Soc. Nephrol [print-electronic]. 2012 Jun; 23(6): 1027-38. PMID: 22440900, PMCID: PMC3358756, PII: ASN.2011040367, DOI: 10.1681/ASN.2011040367, ISSN: 1533-3450.

Zent R, Harris R. The mammalian kidney [editorial]. Exp. Cell Res. 2012 May 5/15/2012; 318(9): v. PMID: 22520051, PII: S0014-4827(12)00185-1, DOI: 10.1016/S0014-4827(12)00185-1, ISSN: 1090-2422.

Gewin L, Zent R. How does TGF-ß mediate tubulointerstitial fibrosis?. Semin. Nephrol. 2012 May; 32(3): 228-35. PMID: 22835453, PII: S0270-9295(12)00061-7, DOI: 10.1016/j.semnephrol.2012.04.001, ISSN: 1558-4488.

Lu Z, Van Horn WD, Chen J, Mathew S, Zent R, Sanders CR. Bicelles at low concentrations. Mol. Pharm [print-electronic]. 2012 Apr 4/2/2012; 9(4): 752-61. PMID: 22221179, PMCID: PMC3319193, DOI: 10.1021/mp2004687, ISSN: 1543-8392.

Praekelt U, Kopp PM, Rehm K, Linder S, Bate N, Patel B, Debrand E, Manso AM, Ross RS, Conti F, Zhang MZ, Harris RC, Zent R, Critchley DR, Monkley SJ. New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2. Eur. J. Cell Biol [print-electronic]. 2012 Mar; 91(3): 180-91. PMID: 22306379, PMCID: PMC3629562, PII: S0171-9335(11)00235-4, DOI: 10.1016/j.ejcb.2011.12.003, ISSN: 1618-1298.

Pozzi A, Zent R. Hold tight or you'll fall off: CD151 helps podocytes stick in high-pressure situations. J. Clin. Invest [print-electronic]. 2012 Jan; 122(1): 13-6. PMID: 22201676, PMCID: PMC3248315, PII: 61858, DOI: 10.1172/JCI61858, ISSN: 1558-8238.

Bulus N, Feral C, Pozzi A, Zent R. CD98 increases renal epithelial cell proliferation by activating MAPKs. PLoS ONE [print-electronic]. 2012; 7(6): e40026. PMID: 22768207, PMCID: PMC3386947, PII: PONE-D-11-23182, DOI: 10.1371/journal.pone.0040026, ISSN: 1932-6203.

Clark PE, Polosukhina D, Love H, Correa H, Coffin C, Perlman EJ, de Caestecker M, Moses HL, Zent R. ß-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors. Am. J. Pathol [print-electronic]. 2011 Dec; 179(6): 3045-55. PMID: 21983638, PMCID: PMC3260797, PII: S0002-9440(11)00808-X, DOI: 10.1016/j.ajpath.2011.08.006, ISSN: 1525-2191.

Pozzi A, Zent R. Extracellular matrix receptors in branched organs. Curr. Opin. Cell Biol [print-electronic]. 2011 Oct; 23(5): 547-53. PMID: 21561755, PMCID: PMC3181278, PII: S0955-0674(11)00051-2, DOI: 10.1016/j.ceb.2011.04.003, ISSN: 1879-0410.

Pozzi A, Zent R. TGF-ß sequestration by mesangial cell integrin avß8: A novel mechanism of glomerular endothelial cell regulation. Am. J. Pathol. 2011 Feb; 178(2): 485-9. PMID: 21281780, PMCID: PMC3069894, PII: S0002-9440(10)00134-3, DOI: 10.1016/j.ajpath.2010.10.038, ISSN: 1525-2191.

Borza CM, Chen X, Mathew S, Mont S, Sanders CR, Zent R, Pozzi A. Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase. J. Biol. Chem [print-electronic]. 2010 Dec 12/17/2010; 285(51): 40114-24. PMID: 20940300, PMCID: PMC3000994, PII: M110.156729, DOI: 10.1074/jbc.M110.156729, ISSN: 1083-351X.

Riggins KS, Mernaugh G, Su Y, Quaranta V, Koshikawa N, Seiki M, Pozzi A, Zent R. MT1-MMP-mediated basement membrane remodeling modulates renal development. Exp. Cell Res [print-electronic]. 2010 Oct 10/15/2010; 316(17): 2993-3005. PMID: 20727881, PMCID: PMC2945451, PII: S0014-4827(10)00397-6, DOI: 10.1016/j.yexcr.2010.08.003, ISSN: 1090-2422.

Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R. Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development. Development. 2010 Oct; 137(19): 3233-43. PMID: 20823064, PMCID: PMC2934735, PII: 137/19/3233, DOI: 10.1242/dev.052845, ISSN: 1477-9129.

Clark PE, Polosukhina DA, Gyabaah K, Moses HL, Thorburn A, Zent R. TRAIL and interferon-alpha act synergistically to induce renal cell carcinoma apoptosis. J. Urol [print-electronic]. 2010 Sep; 184(3): 1166-74. PMID: 20663526, PMCID: PMC2963111, PII: S0022-5347(10)03492-0, DOI: 10.1016/j.juro.2010.04.064, ISSN: 1527-3792.

Gewin L, Bulus N, Mernaugh G, Moeckel G, Harris RC, Moses HL, Pozzi A, Zent R. TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis. J. Am. Soc. Nephrol [print-electronic]. 2010 Aug; 21(8): 1334-43. PMID: 20576806, PMCID: PMC2938601, PII: ASN.2010020147, DOI: 10.1681/ASN.2010020147, ISSN: 1533-3450.

Yamashita H, Tripathi M, Harris MP, Liu S, Weidow B, Zent R, Quaranta V. The role of a recombinant fragment of laminin-332 in integrin alpha3beta1-dependent cell binding, spreading and migration. Biomaterials [print-electronic]. 2010 Jul; 31(19): 5110-21. PMID: 20347131, PMCID: PMC2861493, PII: S0142-9612(10)00343-1, DOI: 10.1016/j.biomaterials.2010.03.003, ISSN: 1878-5905.

Wang SE, Yu Y, Criswell TL, Debusk LM, Lin PC, Zent R, Johnson DH, Ren X, Arteaga CL. Oncogenic mutations regulate tumor microenvironment through induction of growth factors and angiogenic mediators. Oncogene [print-electronic]. 2010 Jun 6/10/2010; 29(23): 3335-48. PMID: 20383197, PMCID: PMC2883631, PII: onc2010112, DOI: 10.1038/onc.2010.112, ISSN: 1476-5594.

Chen X, Whiting C, Borza C, Hu W, Mont S, Bulus N, Zhang MZ, Harris RC, Zent R, Pozzi A. Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression. Mol. Cell. Biol [print-electronic]. 2010 Jun; 30(12): 3048-58. PMID: 20368353, PMCID: PMC2876688, PII: MCB.00892-09, DOI: 10.1128/MCB.00892-09, ISSN: 1098-5549.

He W, Wang Y, Zhang MZ, You L, Davis LS, Fan H, Yang HC, Fogo AB, Zent R, Harris RC, Breyer MD, Hao CM. Sirt1 activation protects the mouse renal medulla from oxidative injury. J. Clin. Invest [print-electronic]. 2010 Apr; 120(4): 1056-68. PMID: 20335659, PMCID: PMC2846063, PII: 41563, DOI: 10.1172/JCI41563, ISSN: 1558-8238.

Pozzi A, Zent R. ZO-1 and ZONAB interact to regulate proximal tubular cell differentiation [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2010 Mar; 21(3): 388-90. PMID: 20133486, PMCID: PMC4473249, PII: ASN.2010010061, DOI: 10.1681/ASN.2010010061, ISSN: 1533-3450.

Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV. Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood [print-electronic]. 2009 Nov 11/26/2009; 114(23): 4897-906. PMID: 19789387, PMCID: PMC2786295, PII: blood-2009-02-207134, DOI: 10.1182/blood-2009-02-207134, ISSN: 1528-0020.

Benjamin JT, Gaston DC, Halloran BA, Schnapp LM, Zent R, Prince LS. The role of integrin alpha8beta1 in fetal lung morphogenesis and injury. Dev. Biol [print-electronic]. 2009 Nov 11/15/2009; 335(2): 407-17. PMID: 19769957, PMCID: PMC2783258, PII: S0012-1606(09)01206-8, DOI: 10.1016/j.ydbio.2009.09.021, ISSN: 1095-564X.

Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R. Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature. 2009 Oct 10/15/2009; 461(7266): 1002-6. PMID: 19829382, PII: nature08468, DOI: 10.1038/nature08468, ISSN: 1476-4687.

Zhang X, Mernaugh G, Yang DH, Gewin L, Srichai MB, Harris RC, Iturregui JM, Nelson RD, Kohan DE, Abrahamson D, Fässler R, Yurchenco P, Pozzi A, Zent R. Beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development [print-electronic]. 2009 Oct; 136(19): 3357-66. PMID: 19710172, PMCID: PMC2739149, PII: dev.036269, DOI: 10.1242/dev.036269, ISSN: 1477-9129.

Pozzi A, Zent R, Chetyrkin S, Borza C, Bulus N, Chuang P, Chen D, Hudson B, Voziyan P. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. J. Am. Soc. Nephrol [print-electronic]. 2009 Oct; 20(10): 2119-25. PMID: 19608705, PMCID: PMC2754111, PII: ASN.2008080900, DOI: 10.1681/ASN.2008080900, ISSN: 1533-3450.

Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC. Distinct roles for basal and induced COX-2 in podocyte injury. J. Am. Soc. Nephrol [print-electronic]. 2009 Sep; 20(9): 1953-62. PMID: 19643929, PMCID: PMC2736764, PII: ASN.2009010039, DOI: 10.1681/ASN.2009010039, ISSN: 1533-3450.

Pozzi A, Zent R. Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Wiley Interdiscip Rev Syst Biol Med. 2009 Sep; 1(2): 254-72. PMID: 20835995, PMCID: PMC3789245, DOI: 10.1002/wsbm.7, ISSN: 1939-005X.

Moser M, Legate KR, Zent R, Fässler R. The tail of integrins, talin, and kindlins. Science. 2009 May 5/15/2009; 324(5929): 895-9. PMID: 19443776, PII: 324/5929/895, DOI: 10.1126/science.1163865, ISSN: 1095-9203.

Wang SE, Xiang B, Zent R, Quaranta V, Pozzi A, Arteaga CL. Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res. 2009 Jan 1/15/2009; 69(2): 475-82. PMID: 19147560, PMCID: PMC2629389, PII: 69/2/475, DOI: 10.1158/0008-5472.CAN-08-2649, ISSN: 1538-7445.

Pozzi A, Voziyan PA, Hudson BG, Zent R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr. Pharm. Des. 2009; 15(12): 1318-33. PMID: 19355971, ISSN: 1873-4286.

Moser M, Legate KR, Zent R, Fassler R.. The tail of integrins, talin, and kindlins. Science. 2009; 15((324)): 895-9.

Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A, Zent R. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp. Cell Res [print-electronic]. 2008 Nov 11/15/2008; 314(19): 3593-604. PMID: 18809396, PMCID: PMC2729514, PII: S0014-4827(08)00328-5, DOI: 10.1016/j.yexcr.2008.08.014, ISSN: 1090-2422.

Abair TD, Bulus N, Borza C, Sundaramoorthy M, Zent R, Pozzi A. Functional analysis of the cytoplasmic domain of the integrin {alpha}1 subunit in endothelial cells. Blood [print-electronic]. 2008 Oct 10/15/2008; 112(8): 3242-54. PMID: 18647959, PMCID: PMC2569176, PII: blood-2007-12-126433, DOI: 10.1182/blood-2007-12-126433, ISSN: 1528-0020.

Srichai MB, Hao C, Davis L, Golovin A, Zhao M, Moeckel G, Dunn S, Bulus N, Harris RC, Zent R, Breyer MD. Apoptosis of the thick ascending limb results in acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2008 Aug; 19(8): 1538-46. PMID: 18495962, PMCID: PMC2488270, PII: ASN.2007101101, DOI: 10.1681/ASN.2007101101, ISSN: 1533-3450.

Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R. Transforming growth factor-beta (TGF-beta) and TGF-beta-associated kinase 1 are required for R-Ras-mediated transformation of mammary epithelial cells. Cancer Res. 2008 Aug 8/1/2008; 68(15): 6224-31. PMID: 18676846, PII: 68/15/6224, DOI: 10.1158/0008-5472.CAN-08-0513, ISSN: 1538-7445.

Macias-Perez I, Borza C, Chen X, Yan X, Ibanez R, Mernaugh G, Matrisian LM, Zent R, Pozzi A. Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer. Cancer Res. 2008 Aug 8/1/2008; 68(15): 6127-35. PMID: 18676835, PMCID: PMC2801028, PII: 68/15/6127, DOI: 10.1158/0008-5472.CAN-08-1395, ISSN: 1538-7445.

Montanez E, Ussar S, Schifferer M, Bösl M, Zent R, Moser M, Fässler R. Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 2008 May 5/15/2008; 22(10): 1325-30. PMID: 18483218, PMCID: PMC2377186, PII: 22/10/1325, DOI: 10.1101/gad.469408, ISSN: 0890-9369.

Macias-Perez IM, Zent R, Carmosino M, Breyer MD, Breyer RM, Pozzi A. Mouse EP3 alpha, beta, and gamma receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J. Biol. Chem [print-electronic]. 2008 May 5/2/2008; 283(18): 12538-45. PMID: 18230618, PMCID: PMC2335350, PII: M800105200, DOI: 10.1074/jbc.M800105200, ISSN: 0021-9258.

Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev. Biol [print-electronic]. 2008 Apr 4/15/2008; 316(2): 288-301. PMID: 18328474, PMCID: PMC2396524, PII: S0012-1606(08)00039-0, DOI: 10.1016/j.ydbio.2008.01.022, ISSN: 1095-564X.

Borza CM, Borza DB, Pedchenko V, Saleem MA, Mathieson PW, Sado Y, Hudson HM, Pozzi A, Saus J, Abrahamson DR, Zent R, Hudson BG. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network. J. Am. Soc. Nephrol [print-electronic]. 2008 Apr; 19(4): 677-84. PMID: 18235087, PMCID: PMC2390958, PII: ASN.2007070793, DOI: 10.1681/ASN.2007070793, ISSN: 1533-3450.

Maginnis MS, Mainou BA, Derdowski A, Johnson EM, Zent R, Dermody TS. NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry. J. Virol [print-electronic]. 2008 Apr; 82(7): 3181-91. PMID: 18216114, PMCID: PMC2268482, PII: JVI.01612-07, DOI: 10.1128/JVI.01612-07, ISSN: 1098-5514.

Zeng F, Zhang MZ, Singh AB, Zent R, Harris RC. ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis. Mol. Biol. Cell [print-electronic]. 2007 Nov; 18(11): 4446-56. PMID: 17761534, PMCID: PMC2043549, PII: E07-03-0223, DOI: 10.1091/mbc.E07-03-0223, ISSN: 1059-1524.

Erdogan M, Pozzi A, Bhowmick N, Moses HL, Zent R. Signaling pathways regulating TC21-induced tumorigenesis. J. Biol. Chem [print-electronic]. 2007 Sep 9/21/2007; 282(38): 27713-20. PMID: 17656362, PII: M703037200, DOI: 10.1074/jbc.M703037200, ISSN: 0021-9258.

Rao R, Redha R, Macias-Perez I, Su Y, Hao C, Zent R, Breyer MD, Pozzi A. Prostaglandin E2-EP4 receptor promotes endothelial cell migration via ERK activation and angiogenesis in vivo. J. Biol. Chem [print-electronic]. 2007 Jun 6/8/2007; 282(23): 16959-68. PMID: 17401137, PII: M701214200, DOI: 10.1074/jbc.M701214200, ISSN: 0021-9258.

Chen X, Abair TD, Ibanez MR, Su Y, Frey MR, Dise RS, Polk DB, Singh AB, Harris RC, Zent R, Pozzi A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol. Cell. Biol [print-electronic]. 2007 May; 27(9): 3313-26. PMID: 17339338, PMCID: PMC1899972, PII: MCB.01476-06, DOI: 10.1128/MCB.01476-06, ISSN: 0270-7306.

Voss B, McLaughlin JN, Holinstat M, Zent R, Hamm HE. PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axis. Mol. Pharmacol [print-electronic]. 2007 May; 71(5): 1399-406. PMID: 17303701, PII: mol.106.033365, DOI: 10.1124/mol.106.033365, ISSN: 0026-895X.

Zent R, Pozzi A. Angiogenesis in diabetic nephropathy. Semin. Nephrol. 2007 Mar; 27(2): 161-71. PMID: 17418685, PII: S0270-9295(07)00008-3, DOI: 10.1016/j.semnephrol.2007.01.007, ISSN: 0270-9295.

Dwyer JP, Yates KM, Sumner EL, Stone WJ, Wang Y, Koury MJ, Fogo AB, Zent R. Chronic myeloid leukemia-associated membranoproliferative glomerulonephritis that responded to imatinib mesylate therapy. Clin. Nephrol. 2007 Mar; 67(3): 176-81. PMID: 17390742, ISSN: 0301-0430.

Zent R, Yan X, Su Y, Hudson BG, Borza DB, Moeckel GW, Qi Z, Sado Y, Breyer MD, Voziyan P, Pozzi A. Glomerular injury is exacerbated in diabetic integrin alpha1-null mice. Kidney Int [print-electronic]. 2006 Aug; 70(3): 460-70. PMID: 16775606, PII: 5000359, DOI: 10.1038/sj.ki.5000359, ISSN: 0085-2538.

Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3. J. Biol. Chem [print-electronic]. 2006 Jul 7/28/2006; 281(30): 20932-9. PMID: 16731529, PII: M601147200, DOI: 10.1074/jbc.M601147200, ISSN: 0021-9258.

Liang XB, Ma LJ, Naito T, Wang Y, Madaio M, Zent R, Pozzi A, Fogo AB. Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J. Am. Soc. Nephrol [print-electronic]. 2006 Jul; 17(7): 1886-95. PMID: 16790514, PII: ASN.2005020205, DOI: 10.1681/ASN.2005020205, ISSN: 1046-6673.

Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL. Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression. Oncogene [print-electronic]. 2006 Jun 6/8/2006; 25(24): 3408-23. PMID: 16186809, PII: 1208964, DOI: 10.1038/sj.onc.1208964, ISSN: 0950-9232.

Nakagawa K, Holla VR, Wei Y, Wang WH, Gatica A, Wei S, Mei S, Miller CM, Cha DR, Price E, Zent R, Pozzi A, Breyer MD, Guan Y, Falck JR, Waterman MR, Capdevila JH. Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J. Clin. Invest [print-electronic]. 2006 Jun; 116(6): 1696-702. PMID: 16691295, PMCID: PMC1459070, DOI: 10.1172/JCI27546, ISSN: 0021-9738.

Pozzi A, Coffa S, Bulus N, Zhu W, Chen D, Chen X, Mernaugh G, Su Y, Cai S, Singh A, Brissova M, Zent R. H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis. Mol. Biol. Cell [print-electronic]. 2006 Apr; 17(4): 2046-56. PMID: 16467383, PMCID: PMC1415315, PII: E05-08-0800, DOI: 10.1091/mbc.E05-08-0800, ISSN: 1059-1524.

Zent R, Pozzi A. Antiangiogenic therapy in diabetic nephropathy [editorial]. J. Am. Soc. Nephrol. 2006 Feb; 17(2): 325-7. PMID: 16434503, PII: 17/2/325, DOI: 10.1681/ASN.2005121290, ISSN: 1046-6673.

Moeckel GW, Zhang L, Chen X, Rossini M, Zent R, Pozzi A. Role of integrin alpha1beta1 in the regulation of renal medullary osmolyte concentration. Am. J. Physiol. Renal Physiol [print-electronic]. 2006 Jan; 290(1): F223-31. PMID: 16106035, PII: 00371.2004, DOI: 10.1152/ajprenal.00371.2004, ISSN: 1931-857X.

Mernaugh RL, Yan H, Chen D, Edl J, Hanley G, Pozzi A, Zent R. Production and characterization of mouse ureteric bud cell-specific rat hybridoma antibodies utilizing subtractive immunization and high-throughput screening. J. Immunol. Methods [print-electronic]. 2005 Nov 11/30/2005; 306(1-2): 115-27. PMID: 16212977, PII: S0022-1759(05)00257-7, DOI: 10.1016/j.jim.2005.08.006, ISSN: 0022-1759.

Mai W, Chen D, Ding T, Kim I, Park S, Cho SY, Chu JS, Liang D, Wang N, Wu D, Li S, Zhao P, Zent R, Wu G. Inhibition of Pkhd1 impairs tubulomorphogenesis of cultured IMCD cells. Mol. Biol. Cell [print-electronic]. 2005 Sep; 16(9): 4398-409. PMID: 15975909, PMCID: PMC1196347, PII: E04-11-1019, DOI: 10.1091/mbc.E04-11-1019, ISSN: 1059-1524.

Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int. J. Cancer. 2005 Aug 8/10/2005; 116(1): 52-61. PMID: 15756690, DOI: 10.1002/ijc.20997, ISSN: 0020-7136.

Pozzi A, Macias-Perez I, Abair T, Wei S, Su Y, Zent R, Falck JR, Capdevila JH. Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. J. Biol. Chem [print-electronic]. 2005 Jul 7/22/2005; 280(29): 27138-46. PMID: 15917237, PII: M501730200, DOI: 10.1074/jbc.M501730200, ISSN: 0021-9258.

Cai S, Bulus N, Fonseca-Siesser PM, Chen D, Hanks SK, Pozzi A, Zent R. CD98 modulates integrin beta1 function in polarized epithelial cells. J. Cell. Sci [print-electronic]. 2005 Mar 3/1/2005; 118(Pt 5): 889-99. PMID: 15713750, PII: jcs.01674, DOI: 10.1242/jcs.01674, ISSN: 0021-9533.

Tvorogov D, Wang XJ, Zent R, Carpenter G. Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J. Cell. Sci [print-electronic]. 2005 Feb 2/1/2005; 118(Pt 3): 601-10. PMID: 15657076, PII: jcs.01643, DOI: 10.1242/jcs.01643, ISSN: 0021-9533.

Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, Pozzi A. An orthotopic model of lung cancer to analyze primary and metastatic NSCLC growth in integrin alpha1-null mice. Clin. Exp. Metastasis. 2005; 22(2): 185-93. PMID: 16086239, DOI: 10.1007/s10585-005-7453-8, ISSN: 0262-0898.

Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R, Ginsberg M, Sethi T. CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J. Biol. Chem [print-electronic]. 2004 Dec 12/24/2004; 279(52): 54731-41. PMID: 15485886, PII: M408700200, DOI: 10.1074/jbc.M408700200, ISSN: 0021-9258.

Zent RM, Cothren CC, Moore EE. Gastric trichobezoar and Rapunzel syndrome. J. Am. Coll. Surg. 2004 Dec; 199(6): 990. PMID: 15555984, PII: S1072-7515(04)01049-X, DOI: 10.1016/j.jamcollsurg.2004.03.030, ISSN: 1072-7515.

Chen D, Roberts R, Pohl M, Nigam S, Kreidberg J, Wang Z, Heino J, Ivaska J, Coffa S, Harris RC, Pozzi A, Zent R. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am. J. Physiol. Renal Physiol [print-electronic]. 2004 Oct; 287(4): F602-11. PMID: 15187002, PII: 00015.2004, DOI: 10.1152/ajprenal.00015.2004, ISSN: 1931-857X.

Fisher ME, Rossini M, Simmons E, Harris RC, Moeckel G, Zent R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alfa therapy. Am. J. Kidney Dis. 2004 Sep; 44(3): 567-73. PMID: 15332232, PII: S0272638604008285, ISSN: 1523-6838.

Chen X, Moeckel G, Morrow JD, Cosgrove D, Harris RC, Fogo AB, Zent R, Pozzi A. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am. J. Pathol. 2004 Aug; 165(2): 617-30. PMID: 15277235, PMCID: PMC1618576, PII: S0002-9440(10)63326-3, ISSN: 0002-9440.

Singh AB, Tsukada T, Zent R, Harris RC. Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells. J. Cell. Sci [print-electronic]. 2004 Mar 3/15/2004; 117(Pt 8): 1365-79. PMID: 14996914, PII: jcs.01037, DOI: 10.1242/jcs.01037, ISSN: 0021-9533.

Koshikawa N, Schenk S, Moeckel G, Sharabi A, Miyazaki K, Gardner H, Zent R, Quaranta V. Proteolytic processing of laminin-5 by MT1-MMP in tissues and its effects on epithelial cell morphology. FASEB J [print-electronic]. 2004 Feb; 18(2): 364-6. PMID: 14688206, PII: 03-0584fje, DOI: 10.1096/fj.03-0584fje, ISSN: 1530-6860.

Pedchenko V, Zent R, Hudson BG. Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion. J. Biol. Chem [print-electronic]. 2004 Jan 1/23/2004; 279(4): 2772-80. PMID: 14610079, PII: M311901200, DOI: 10.1074/jbc.M311901200, ISSN: 0021-9258.

Hata AN, Zent R, Breyer MD, Breyer RM. Expression and molecular pharmacology of the mouse CRTH2 receptor. J. Pharmacol. Exp. Ther [print-electronic]. 2003 Aug; 306(2): 463-70. PMID: 12721327, PII: jpet.103.050955, DOI: 10.1124/jpet.103.050955, ISSN: 0022-3565.

Pozzi A, Zent R. Integrins: sensors of extracellular matrix and modulators of cell function. Nephron Exp. Nephrol. 2003; 94(3): e77-84. PMID: 12902617, PII: 72025, DOI: 72025, ISSN: 1660-2129.

Bhowmick NA, Zent R, Ghiassi M, McDonnell M, Moses HL. Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity. J. Biol. Chem [print-electronic]. 2001 Dec 12/14/2001; 276(50): 46707-13. PMID: 11590169, PII: M106176200, DOI: 10.1074/jbc.M106176200, ISSN: 0021-9258.

Zent R, Bush KT, Pohl ML, Quaranta V, Koshikawa N, Wang Z, Kreidberg JA, Sakurai H, Stuart RO, Nigám SK. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev. Biol. 2001 Oct 10/15/2001; 238(2): 289-302. PMID: 11784011, PII: S0012-1606(01)90391-4, DOI: 10.1006/dbio.2001.0391, ISSN: 0012-1606.

Fenczik CA, Zent R, Dellos M, Calderwood DA, Satriano J, Kelly C, Ginsberg MH. Distinct domains of CD98hc regulate integrins and amino acid transport. J. Biol. Chem [print-electronic]. 2001 Mar 3/23/2001; 276(12): 8746-52. PMID: 11121428, PII: M011239200, DOI: 10.1074/jbc.M011239200, ISSN: 0021-9258.

Zent R, Fenczik CA, Calderwood DA, Liu S, Dellos M, Ginsberg MH. Class- and splice variant-specific association of CD98 with integrin beta cytoplasmic domains. J. Biol. Chem. 2000 Feb 2/18/2000; 275(7): 5059-64. PMID: 10671548, ISSN: 0021-9258.

Calderwood DA, Zent R, Grant R, Rees DJ, Hynes RO, Ginsberg MH. The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J. Biol. Chem. 1999 Oct 10/1/1999; 274(40): 28071-4. PMID: 10497155, ISSN: 0021-9258.

Zent R, Ailenberg M, Downey GP, Silverman M. ROS stimulate reorganization of mesangial cell-collagen gels by tyrosine kinase signaling. Am. J. Physiol. 1999 Feb; 276(2 Pt 2): F278-87. PMID: 9950959, ISSN: 0002-9513.

Zent R, Ailenberg M, Silverman M. Tyrosine kinase cell signaling pathways of rat mesangial cells in 3-dimensional cultures: response to fetal bovine serum and platelet-derived growth factor-BB. Exp. Cell Res. 1998 Apr 4/10/1998; 240(1): 134-43. PMID: 9570928, PII: S0014-4827(98)94008-3, DOI: 10.1006/excr.1998.4008, ISSN: 0014-4827.

Zent R, Katz A, Quaggin S, Cattran D, Wade J, Cardella C, Zaltzman J, Fenton S, Cole E. Thrombotic microangiopathy in renal transplant recipients treated with cyclosporin A. Clin. Nephrol. 1997 Mar; 47(3): 181-6. PMID: 9105765, ISSN: 0301-0430.

Zent R, Nagai R, Cattran DC. Idiopathic membranous nephropathy in the elderly: a comparative study. Am. J. Kidney Dis. 1997 Feb; 29(2): 200-6. PMID: 9016890, PII: S0272-6386(97)90030-5, ISSN: 0272-6386.

De Villiers C, Zent R, Eastman RW, Swingler D. A flight of fantasy: false memories in frontal lobe disease [letter]. J. Neurol. Neurosurg. Psychiatr. 1996 Dec; 61(6): 652-3. PMID: 8971120, PMCID: PMC486667, ISSN: 0022-3050.

Zent R, Ailenberg M, Waddell TK, Downey GP, Silverman M. Puromycin aminonucleoside inhibits mesangial cell-induced contraction of collagen gels by stimulating production of reactive oxygen species. Kidney Int. 1995 Mar; 47(3): 811-7. PMID: 7752581, ISSN: 0085-2538.

Katz A, Zent R, Bargman JM. IgG heavy-chain deposition disease. Mod. Pathol. 1994 Oct; 7(8): 874-8. PMID: 7838842, ISSN: 0893-3952.

Zent R, Van Zyl Smit R, Duffield M, Cassidy MJ. Crescentic nephritis at Groote Schuur Hospital, South Africa--not a benign disease. Clin. Nephrol. 1994 Jul; 42(1): 22-9. PMID: 7923962, ISSN: 0301-0430.

Bargman JM, Zent R, Ellis P, Auger M, Wilson S. Diagnosis of lymphoma in a continuous ambulatory peritoneal dialysis patient by peritoneal fluid cytology. Am. J. Kidney Dis. 1994 May; 23(5): 747-50. PMID: 8172221, PII: S0272638694001010, ISSN: 0272-6386.

Zent R, Myers JE, Donald D, Rayner BL. Continuous ambulatory peritoneal dialysis: an option in the developing world?. Perit Dial Int. 1994; 14(1): 48-51. PMID: 8312414, ISSN: 0896-8608.

Morton LP, Reynolds L, Zent R, Rayner BL. Hearing thresholds in CAPD patients. Adv Perit Dial. 1992; 8: 150-2. PMID: 1361774, ISSN: 1197-8554.