Joyce E. Johnson, M.D.

Faculty Appointments
Professor of Pathology, Microbiology and Immunology
M.D., Medicine , Vanderbilt University, Nashville, TennesseeB.A., Rice University, Houston, Texas
Office Address
C-3321 MCN
Department of Pathology
1161 21st Ave S
Nashville, TN 37232-2561
Research Description
I do translational research in lung cancer diagnosis and pathogenesis, the immunopathology of infections and autoimmune lung diseases, and cytopathologic diagnosis.
Clinical Description
I practice Anatomic Pathology, with special interest in lung diseases and cytopathology.

At Vanderbilt University Hospital I cover the Thoracic, Heart, and Frozen Section services in Surgical Pathology, and non-GYN and GYN/GU services in Cytopathology.

At the VA I direct the Anatomic Pathology services, where we maintain a general practice in Surgical Pathology and Cytopathology.
Research Keywords
Histopathology and immunopathology of pediatric viral pneumonias; etiology and pathogenesis of idiopathic interstitial lung diseases; cytologic diagnosis of disease.
Clinical Research Keywords
Cytopathology, Surgical Pathology, Thoracic DIseases
Atlas of Pulmonary Cytopathology with Histopathologic Correlations. First. New York (United States): Springer/Demos Medical; 2017 Nov 11/1/2017.207 p. ISBN-13: 9781936287161.. Available from: Pulmonary Cytology-Histology correlations with detailed diagnostic criteria in the figure legends.

King MS, Eisenberg RE, , Newman JH, Tolle J, Harrell NH, Ninan M, Lambright ES, Sheller JR, , Johnson JE, Miller RF.. Exercise dysfunction associated with constrictive bronchiolitis in United States soldiers returning from Iraq and Afghanistan. NEJM. 2011; 365: 222-30.

Lopez MF, Monsalvo AC, Batalle JP, Zea J, Maskin B, Bugna J, Krause J, Rubinstein C, Aguilar L, Dalurzo L, Libster R, Savy V, Baumeister E, Aguilar L, Cabral G, Font J, Weller K, Echavarria M, Edwards KM, Chappell JD, Williams JV, Crowe JE, Johnson J, Melendi GA, Polack FP.. Severe pandemic 2009 H1N1 Influenza disease due to pathogenic immune complexes. Nature Medicine. 2011; 17: 195-9.

Ryder AB, Tollefson SJ, Podsiad AB, Johnson JE, Williams JV. Soluble recombinant human metapneumovirus G protein is immunogenic but not protective. Vaccine [print-electronic]. 2010 Jun 6/7/2010; 28(25): 4145-52. PMID: 20417260, PMCID: PMC2894472, PII: S0264-410X(10)00500-1, DOI: 10.1016/j.vaccine.2010.04.007, ISSN: 1873-2518.

Crossno PF, Polosukhin VV, Blackwell TS, Johnson JE, Markin C, Moore PE, Worrell JA, Stahlman MT, Phillips JA, Loyd JE, Cogan JD, Lawson WE. Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest. 2010 Apr; 137(4): 969-73. PMID: 20371530, PMCID: PMC2851554, PII: 137/4/969, DOI: 10.1378/chest.09-0790, ISSN: 1931-3543.

Allen SS, Evans W, Carlisle J, Hajizadeh R, Nadaf M, Shepherd BE, Pride DT, Johnson JE, Drake WP. Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses. Respir. Res. 2008; 9: 36. PMID: 18439270, PMCID: PMC2383887, PII: 1465-9921-9-36, DOI: 10.1186/1465-9921-9-36, ISSN: 1465-993X.

Devin JK, Johnson JE, Eren M, Gleaves LA, Bradham WS, Bloodworth JR, Vaughan DE. Transgenic overexpression of plasminogen activator inhibitor-1 promotes the development of polycystic ovarian changes in female mice. J. Mol. Endocrinol. 2007 Jul; 39(1): 9-16. PMID: 17601881, PII: 39/1/9, DOI: 10.1677/JME-06-0057, ISSN: 1479-6813.

Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS. The histopathology of fatal untreated human respiratory syncytial virus infection. Mod. Pathol [print-electronic]. 2007 Jan; 20(1): 108-19. PMID: 17143259, PII: 3800725, DOI: 10.1038/modpathol.3800725, ISSN: 0893-3952.

Cseke G, Wright DW, Tollefson SJ, Johnson JE, Crowe JE, Williams JV. Human metapneumovirus fusion protein vaccines that are immunogenic and protective in cotton rats. J. Virol [print-electronic]. 2007 Jan; 81(2): 698-707. PMID: 17050599, PMCID: PMC1797435, PII: JVI.00844-06, DOI: 10.1128/JVI.00844-06, ISSN: 0022-538X.

Cheng Q, Zhao Y, Lawson WE, Polosukhin VV, Johnson JE, Blackwell TS, Gailani D. The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice. Blood [print-electronic]. 2005 Nov 11/1/2005; 106(9): 3055-7. PMID: 15985536, PMCID: PMC1895339, PII: 2005-02-0577, DOI: 10.1182/blood-2005-02-0577, ISSN: 0006-4971.

Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, Pozzi A, Baldwin HS, Johnson JE, de Caestecker MP. Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ. Res [print-electronic]. 2005 Sep 9/2/2005; 97(5): 496-504. PMID: 16100039, PII: 01.RES.0000181152.65534.07, DOI: 10.1161/01.RES.0000181152.65534.07, ISSN: 1524-4571.

Williams JV, Tollefson SJ, Johnson JE, Crowe JE. The cotton rat (Sigmodon hispidus) is a permissive small animal model of human metapneumovirus infection, pathogenesis, and protective immunity. J. Virol. 2005 Sep; 79(17): 10944-51. PMID: 16103146, PMCID: PMC1193579, PII: 79/17/10944, DOI: 10.1128/JVI.79.17.10944-10951.2005, ISSN: 0022-538X.

Wright PF, Ikizler MR, Gonzales RA, Carroll KN, Johnson JE, Werkhaven JA. Growth of respiratory syncytial virus in primary epithelial cells from the human respiratory tract. J. Virol. 2005 Jul; 79(13): 8651-4. PMID: 15956607, PMCID: PMC1143745, PII: 79/13/8651, DOI: 10.1128/JVI.79.13.8651-8654.2005, ISSN: 0022-538X.

Miller GG, Destarac L, Zeevi A, Girnita A, McCurry K, Iacono A, Murray JJ, Crowe D, Johnson JE, Ninan M, Milstone AP. Acute humoral rejection of human lung allografts and elevation of C4d in bronchoalveolar lavage fluid. Am. J. Transplant. 2004 Aug; 4(8): 1323-30. PMID: 15268735, PII: AJT508, DOI: 10.1111/j.1600-6143.2004.00508.x, ISSN: 1600-6135.

Halasa NB, Barr FE, Johnson JE, Edwards KM. Fatal pulmonary hypertension associated with pertussis in infants: does extracorporeal membrane oxygenation have a role?. Pediatrics. 2003 Dec; 112(6 Pt 1): 1274-8. PMID: 14654596, ISSN: 1098-4275.

Schröder C, Wu GS, Price E, Johnson JE, Pierson RN, Azimzadeh AM. Hyperacute rejection of mouse lung by human blood: characterization of the model and the role of complement. Transplantation. 2003 Sep 9/15/2003; 76(5): 755-60. PMID: 14501848, DOI: 10.1097/01.TP.0000069836.91593.09, ISSN: 0041-1337.

Tang YW, Johnson JE, Browning PJ, Cruz-Gervis RA, Davis A, Graham BS, Brigham KL, Oates JA, Loyd JE, Stecenko AA. Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis. J. Clin. Microbiol. 2003 Jun; 41(6): 2633-40. PMID: 12791891, PMCID: PMC156536, ISSN: 0095-1137.

Goldstein RE, Netterville JL, Burkey B, Johnson JE. Implications of follicular neoplasms, atypia, and lesions suspicious for malignancy diagnosed by fine-needle aspiration of thyroid nodules. Ann. Surg. 2002 May; 235(5): 656-62; discussion 662. PMID: 11981211, PMCID: PMC1422491, ISSN: 0003-4932.

Pietsch JB, Shankar S, Ford C, Johnson JE. Obstructive jaundice secondary to lymphoma in childhood. J. Pediatr. Surg. 2001 Dec; 36(12): 1792-5. PMID: 11733908, PII: S0022-3468(01)22015-6, DOI: 10.1053/jpsu.2001.28840, ISSN: 1531-5037.

Foster MR, Johnson JE, Olson SJ, Allred DC. Immunohistochemical analysis of nuclear versus cytoplasmic staining of WT1 in malignant mesotheliomas and primary pulmonary adenocarcinomas. Arch. Pathol. Lab. Med. 2001 Oct; 125(10): 1316-20. PMID: 11570906, DOI: 10.1043/0003-9985(2001)125<1316:IAONVC>2.0.CO;2, ISSN: 0003-9985.

Lowe LH, Isuani BH, Heller RM, Stein SM, Johnson JE, Navarro OM, Hernanz-Schulman M. Pediatric renal masses: Wilms tumor and beyond. Radiographics. 2000 Nov; 20(6): 1585-603. PMID: 11112813, DOI: 10.1148/radiographics.20.6.g00nv051585, ISSN: 0271-5333.

Fischer JE, Johnson JE, Johnson TR, Graham BS. Pertussis toxin sensitization alters the pathogenesis of subsequent respiratory syncytial virus infection. J. Infect. Dis [print-electronic]. 2000 Oct; 182(4): 1029-38. PMID: 10979896, PII: JID000032, DOI: 10.1086/315806, ISSN: 0022-1899.

Aronica MA, Mora AL, Mitchell DB, Finn PW, Johnson JE, Sheller JR, Boothby MR. Preferential role for NF-kappa B/Rel signaling in the type 1 but not type 2 T cell-dependent immune response in vivo. J. Immunol. 1999 Nov 11/1/1999; 163(9): 5116-24. PMID: 10528218, PII: ji_v163n9p5116, ISSN: 0022-1767.

Fisher RG, Johnson JE, Dillon SB, Parker RA, Graham BS. Prophylaxis with respiratory syncytial virus F-specific humanized monoclonal antibody delays and moderately suppresses the native antibody response but does not impair immunity to late rechallenge. J. Infect. Dis. 1999 Sep; 180(3): 708-13. PMID: 10438358, PII: JID990121, DOI: 10.1086/314965, ISSN: 0022-1899.