James V. Gainer, III, M.D.

Assistant Professor

jay.gainer@vanderbilt.edu
Faculty Appointments
Assistant Professor of Medicine
Education
M.D., West Virginia University, Morgantown, West VirginiaB.S., University of Virginia, Charlottesville, Virginia
Office Address
560 RRB
TN 6602
Publications
Gainer JV, Lipkowitz MS, Yu C, Waterman MR, Dawson EP, Capdevila JH, Brown NJ, . Association of a CYP4A11 variant and blood pressure in black men. J. Am. Soc. Nephrol [print-electronic]. 2008 Aug; 19(8): 1606-12. PMID: 18385420, PMCID: PMC2488260, PII: ASN.2008010063, DOI: 10.1681/ASN.2008010063, ISSN: 1533-3450.

Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, Brown NJ. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension [print-electronic]. 2008 Feb; 51(2): 454-9. PMID: 18180402, PMCID: PMC2581632, PII: HYPERTENSIONAHA.107.102574, DOI: 10.1161/HYPERTENSIONAHA.107.102574, ISSN: 1524-4563.

Byrd JB, Touzin K, Sile S, Gainer JV, Yu C, Nadeau J, Adam A, Brown NJ. Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Hypertension [print-electronic]. 2008 Jan; 51(1): 141-7. PMID: 18025295, PMCID: PMC2749928, PII: HYPERTENSIONAHA.107.096552, DOI: 10.1161/HYPERTENSIONAHA.107.096552, ISSN: 1524-4563.

Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clin. Pharmacol. Ther [print-electronic]. 2008 Jan; 83(1): 122-9. PMID: 17522594, PII: 6100250, DOI: 10.1038/sj.clpt.6100250, ISSN: 1532-6535.

Sile S, Gillani NB, Velez DR, Vanoye CG, Yu C, Byrne LM, Gainer JV, Brown NJ, Williams SM, George AL. Functional BSND variants in essential hypertension. Am. J. Hypertens. 2007 Nov; 20(11): 1176-82. PMID: 17954364, PII: S0895-7061(07)00388-3, DOI: 10.1016/j.amjhyper.2007.07.003, ISSN: 0895-7061.

Darbar D, Motsinger AA, Ritchie MD, Gainer JV, Roden DM. Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm [print-electronic]. 2007 Jun; 4(6): 743-9. PMID: 17556195, PMCID: PMC1948880, PII: S1547-5271(07)00118-X, DOI: 10.1016/j.hrthm.2007.02.006, ISSN: 1547-5271.

Luther JM, Gainer JV, Murphey LJ, Yu C, Vaughan DE, Morrow JD, Brown NJ. Angiotensin II induces interleukin-6 in humans through a mineralocorticoid receptor-dependent mechanism. Hypertension [print-electronic]. 2006 Dec; 48(6): 1050-7. PMID: 17043157, PII: 01.HYP.0000248135.97380.76, DOI: 10.1161/01.HYP.0000248135.97380.76, ISSN: 1524-4563.

Zamorano R, Suchindran S, Gainer JV. 3'-Untranslated region of the type 2 bradykinin receptor is a potent regulator of gene expression. Am. J. Physiol. Renal Physiol [print-electronic]. 2006 Feb; 290(2): F456-64. PMID: 16144969, PII: 00009.2005, DOI: 10.1152/ajprenal.00009.2005, ISSN: 1931-857X.

Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation [print-electronic]. 2005 Jan 1/4/2005; 111(1): 63-9. PMID: 15611369, PII: 01.CIR.0000151309.82473.59, DOI: 10.1161/01.CIR.0000151309.82473.59, ISSN: 1524-4539.

Summar ML, Gainer JV, Pretorius M, Malave H, Harris S, Hall LD, Weisberg A, Vaughan DE, Christman BW, Brown NJ. Relationship between carbamoyl-phosphate synthetase genotype and systemic vascular function. Hypertension [print-electronic]. 2004 Feb; 43(2): 186-91. PMID: 14718356, PII: 01.HYP.0000112424.06921.52, DOI: 10.1161/01.HYP.0000112424.06921.52, ISSN: 1524-4563.

Bellamine A, Wang Y, Waterman MR, Gainer JV, Dawson EP, Brown NJ, Capdevila JH. Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Arch. Biochem. Biophys. 2003 Jan 1/1/2003; 409(1): 221-7. PMID: 12464262, PII: S0003986102005453, ISSN: 0003-9861.

Rosenbaum DA, Pretorius M, Gainer JV, Byrne D, Murphey LJ, Painter CA, Vaughan DE, Brown NJ. Ethnicity affects vasodilation, but not endothelial tissue plasminogen activator release, in response to bradykinin. Arterioscler. Thromb. Vasc. Biol. 2002 Jun 6/1/2002; 22(6): 1023-8. PMID: 12067915, ISSN: 1524-4636.

Wilsdorf T, Gainer JV, Murphey LJ, Vaughan DE, Brown NJ. Angiotensin-(1-7) does not affect vasodilator or TPA responses to bradykinin in human forearm. Hypertension. 2001 Apr; 37(4): 1136-40. PMID: 11304515, ISSN: 1524-4563.

Gainer JV, Stein CM, Neal T, Vaughan DE, Brown NJ. Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity. Hypertension. 2001 Jan; 37(1): 46-51. PMID: 11208755, ISSN: 1524-4563.

Gainer JV, Brown NJ, Bachvarova M, Bastien L, Maltais I, Marceau F, Bachvarov DR. Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans. Am. J. Hypertens. 2000 Dec; 13(12): 1268-73. PMID: 11130770, PII: S0895706100012152, ISSN: 0895-7061.

Brown NJ, Gainer JV, Murphey LJ, Vaughan DE. Bradykinin stimulates tissue plasminogen activator release from human forearm vasculature through B(2) receptor-dependent, NO synthase-independent, and cyclooxygenase-independent pathway. Circulation. 2000 Oct 10/31/2000; 102(18): 2190-6. PMID: 11056091, ISSN: 1524-4539.

Murphey LJ, Gainer JV, Vaughan DE, Brown NJ. Angiotensin-converting enzyme insertion/deletion polymorphism modulates the human in vivo metabolism of bradykinin. Circulation. 2000 Aug 8/22/2000; 102(8): 829-32. PMID: 10952948, ISSN: 1524-4539.

Xie HG, Stein CM, Kim RB, Gainer JV, Sofowora G, Dishy V, Brown NJ, Goree RE, Haines JL, Wood AJ. Human beta2-adrenergic receptor polymorphisms: no association with essential hypertension in black or white Americans. Clin. Pharmacol. Ther. 2000 Jun; 67(6): 670-5. PMID: 10872649, PII: S0009-9236(00)45798-X, DOI: 10.1067/mcp.2000.106293, ISSN: 0009-9236.

Xie HG, Kim RB, Stein CM, Gainer JV, Brown NJ, Wood AJ. Alpha1A-adrenergic receptor polymorphism: association with ethnicity but not essential hypertension. Pharmacogenetics. 1999 Oct; 9(5): 651-6. PMID: 10591546, ISSN: 0960-314X.

Xie HG, Stein CM, Kim RB, Xiao ZS, He N, Zhou HH, Gainer JV, Brown NJ, Haines JL, Wood AJ. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics. 1999 Aug; 9(4): 511-6. PMID: 10780271, ISSN: 0960-314X.

Brown NJ, Gainer JV, Stein CM, Vaughan DE. Bradykinin stimulates tissue plasminogen activator release in human vasculature. Hypertension. 1999 Jun; 33(6): 1431-5. PMID: 10373228, ISSN: 0194-911X.

Gainer JV, Morrow JD, Loveland A, King DJ, Brown NJ. Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects. N. Engl. J. Med. 1998 Oct 10/29/1998; 339(18): 1285-92. PMID: 9791144, DOI: 10.1056/NEJM199810293391804, ISSN: 0028-4793.

Gainer JV, Hunley TE, Kon V, Nadeau JH, Muldowney JA, Brown NJ. Angiotensin II type I receptor polymorphism in African Americans lower frequency of the C1166 variant. Biochem. Mol. Biol. Int. 1997 Sep; 43(1): 227-31. PMID: 9315301, ISSN: 1039-9712.

Brown NJ, Ryder D, Gainer JV, Morrow JD, Nadeau J. Differential effects of angiotensin converting enzyme inhibitors on the vasodepressor and prostacyclin responses to bradykinin. J. Pharmacol. Exp. Ther. 1996 Nov; 279(2): 703-12. PMID: 8930174, ISSN: 0022-3565.

Gainer JV, Nadeau JH, Ryder D, Brown NJ. Increased sensitivity to bradykinin among African Americans. J. Allergy Clin. Immunol. 1996 Aug; 98(2): 283-7. PMID: 8757204, PII: S0091-6749(96)70151-3, ISSN: 0091-6749.