Harold N. Lovvorn, III, M.D.

Associate Professor

Faculty Appointments
Acting Chair, Department of Pediatric Surgery Associate Professor of Pediatric Surgery Associate Professor of Pediatrics
M.D., Medicine, University of Tennessee Center for Health Science, Memphis, TennesseeB.S., Psychology, Duke University, Durham, North Carolina
Office Address
Suite 4150 Doctor's Office Tower
2200 Children's Way
Nashville, TN 37232-9780
Research Description
Research includes the study of Wilms' tumorigenesis that will hopefully lead to applicable lessons to embyonal tumorigenesis in general. The laboratory as a whole studies the transcriptional programs that regulate the mesenchymal-to-epithelial conversion of the developing kidney.Because Wilms' tumors are thought to arise from altered regulation of this conversion process, an event essential for progenitor cell differentiation and normal morphogenesis, it is the hope to gain a better understanding of how these normal nephrogenic events must fail and give rise to the persistence and expansion of the metanephric blastema in the development of Wilms' tumor.
Research Keywords
cited1 and 2 Wilms'
Austin MT, Leys CM, Feurer ID, Lovvorn HN, O'Neill JA, Pinson CW, Pietsch JB. Liver transplantation for childhood hepatic malignancy: a review of the United Network for Organ Sharing (UNOS) database. J. Pediatr. Surg. 2006 Jan; 41(1): 182-6. PMID: 16410130, PII: S0022-3468(05)00764-5, DOI: 10.1016/j.jpedsurg.2005.10.091, ISSN: 1531-5037.

Leys CM, Austin MT, Pietsch JB, Lovvorn HN, Pietsch JB. Elective intestinal operations in infants and children without mechanical bowel preparation: a pilot study. J. Pediatr. Surg. 2005 Jun; 40(6): 978-81; discussion 982. PMID: 15991181, PII: S0022346805002071, DOI: 10.1016/j.jpedsurg.2005.03.013, ISSN: 1531-5037.

Agarwal HS, Taylor MB, Grzeszczak MJ, Lovvorn HN, Hunley TE, Jabs K, Shankar V. Extra corporeal membrane oxygenation and plasmapheresis for pulmonary hemorrhage in microscopic polyangiitis. Pediatr. Nephrol [print-electronic]. 2005 Apr; 20(4): 526-8. PMID: 15714314, DOI: 10.1007/s00467-004-1724-5, ISSN: 0931-041X.

Austin MT, Lovvorn HN, Feurer ID, Pietsch J, Earl TM, Bartilson R, Neblett WW, Pietsch JB. Congenital diaphragmatic hernia repair on extracorporeal life support: a decade of lessons learned. Am Surg. 2004 May; 70(5): 389-95; discussion 395. PMID: 15156945, ISSN: 0003-1348.

Prasad R, Lovvorn HN, Wadie GM, Lobe TE. Early experience with needleoscopic inguinal herniorrhaphy in children. J. Pediatr. Surg. 2003 Jul; 38(7): 1055-8. PMID: 12861538, PII: S002234680300191X, ISSN: 1531-5037.

Menschik D, Lovvorn H, Hill A, Kelly P, Jones DP. An unusual etiology of hypertension in a 5-year-old boy. Pediatr. Nephrol [print-electronic]. 2002 Jul; 17(7): 524-6. PMID: 12172767, DOI: 10.1007/s00467-002-0882-6, ISSN: 0931-041X.

Lovvorn HN, Rothenberg SS, Reinberg O, Yeung CK, Lobe TE. Update on thorascopic repair of esophageal atresia with and without tracheoesophageal fitula. Pediatr Endosurg Innov Tech. 2001; 5((2)): 135-9.

Lovvorn HN, Savani RC, Ruchelli E, Cass DL, Adzick NS. Serum hyaluronan and its association with unfavorable histology and aggressiveness of heterotransplanted Wilms' tumor. J. Pediatr. Surg. 2000 Jul; 35(7): 1070-8. PMID: 10917299, PII: S0022-3468(00)24263-2, DOI: 10.1053/jpsu.2000.7774, ISSN: 0022-3468.

Lovvorn HN, Nance ML, Ferry RJ, Stolte L, Baker L, O'Neill JA, Schnaufer L, Stanley CA, Adzick NS. Congenital hyperinsulinism and the surgeon: lessons learned over 35 years. J. Pediatr. Surg. 1999 May; 34(5): 786-92; discussion 792. PMID: 10359182, PII: S0022-3468(99)90374-3, ISSN: 0022-3468.

Lovvorn HN, Cheung DT, Nimni ME, Perelman N, Estes JM, Adzick NS. Relative distribution and crosslinking of collagen distinguish fetal from adult sheep wound repair. J. Pediatr. Surg. 1999 Jan; 34(1): 218-23. PMID: 10022176, PII: S0022-3468(99)90261-0, ISSN: 0022-3468.

Cass DL, Lovvorn HN, Yang EY, Sylvester KG, Adzick NS. Regenerative capabilities of the fetal vascular wall. Surg Forum. 1999; 50: 468-9.

Lovvorn HN, Cass DL, Sylvester KG, Yang EY, Crombleholme TM, Adzick NS, Savani RC. Hyaluronan receptor expression increases in fetal excisional skin wounds and correlates with fibroplasia. J. Pediatr. Surg. 1998 Jul; 33(7): 1062-9; discussion 1069. PMID: 9694095, PII: S0022-3468(98)90532-2, ISSN: 0022-3468.

Lovvorn HN, Tucci LA, Stafford PW. Ovarian masses in the pediatric patient. AORN J. 1998 Mar; 67(3): 568-76; quiz 577, 580. PMID: 9541702, ISSN: 0001-2092.

Lovvorn HN, Crombleholme TM, Drott H, Flake AW, Adzick NS. Maternal colloid osmotic pressure after fetal surgery. Surg Forum. 1998; 49: 481-3.

Lovvrn HN, Adzick NS. Clinical Urography. [place unknown: publisher unknown]; 1998. (2).

Liechty KW, Crombleholme TM, Sylvester KG, Lovvorn HN, Kitano Y, Cass DL, Adzick NS. Differential IL-6 production by fetal versus adult fibroblasts. Surg Forum. 1997; 48: 649-51.