Ginger E. Holt, M.D.

Faculty Appointments
Professor of Orthopaedic Surgery and Rehabilitation
M.D., Medicine, University of Alabama, Birmingham, AlabamaB.S., Biology, University of Alabama, Birmingham, Alabama
Office Address
Medical Center East, South Tower, Suite 4200
1215 21st Avenue South
Nashville, TN 37232-8774
Research Keywords
tissue engineering, cancer biology
Bauer JM, Holt GE. National Orthopedic Residency Attrition: Who Is At Risk?. J Surg Educ [print-electronic]. 2016 May 5/20/2016; PMID: 27216301, PII: S1931-7204(16)00061-1, DOI: 10.1016/j.jsurg.2016.03.010, ISSN: 1878-7452.

Ning MS, Perkins SM, Borinstein SC, Holt GE, Stavas MJ, Shinohara ET. Role of radiation in the treatment of non-metastatic osseous Ewing sarcoma. J Med Imaging Radiat Oncol [print-electronic]. 2016 Feb; 60(1): 119-28. PMID: 26439449, DOI: 10.1111/1754-9485.12389, ISSN: 1754-9485.

Alamanda VK, Song Y, Schwartz HS, Holt GE. Racial Disparities in Extremity Soft-Tissue Sarcoma Outcomes: A Nationwide Analysis. Am. J. Clin. Oncol. 2015 Dec; 38(6): 595-9. PMID: 24401671, DOI: 10.1097/COC.0000000000000004, ISSN: 1537-453X.

Wilson RJ, Zumsteg JW, Hartley KA, Long JH, Mesko NW, Halpern JL, Schwartz HS, Holt GE. Overutilization and Cost of Advanced Imaging for Long-Bone Cartilaginous Lesions. Ann. Surg. Oncol [print-electronic]. 2015 Oct; 22(11): 3466-73. PMID: 25564171, PII: 10.1245/s10434-014-4325-y, DOI: 10.1245/s10434-014-4325-y, ISSN: 1534-4681.

Delisca GO, Mesko NW, Alamanda VK, Archer KR, Song Y, Halpern JL, Schwartz HS, Holt GE. MFH and high-grade undifferentiated pleomorphic sarcoma-what's in a name?. J Surg Oncol [print-electronic]. 2015 Feb; 111(2): 173-7. PMID: 25219789, DOI: 10.1002/jso.23787, ISSN: 1096-9098.

Wilson RJ, Alamanda VK, Hartley KG, Mesko NW, Halpern JL, Schwartz HS, Holt GE. Sarcopenia Does Not Affect Survival or Outcomes in Soft-Tissue Sarcoma. Sarcoma [print-electronic]. 2015; 2015: 146481. PMID: 26696772, PMCID: PMC4678075, DOI: 10.1155/2015/146481, ISSN: 1357-714X.

Mesko NW, Mesko JL, Gaffney LM, Halpern JL, Schwartz HS, Holt GE. Medical malpractice and sarcoma care--a thirty-three year review of case resolutions, inciting factors, and at risk physician specialties surrounding a rare diagnosis. J Surg Oncol [print-electronic]. 2014 Dec; 110(8): 919-29. PMID: 25155556, DOI: 10.1002/jso.23770, ISSN: 1096-9098.

Alamanda VK, Song Y, Shinohara E, Schwartz HS, Holt GE. Postoperative radiation boost does not improve local recurrence rates in extremity soft tissue sarcomas. J Med Imaging Radiat Oncol [print-electronic]. 2014 Oct; 58(5): 633-40. PMID: 24821569, DOI: 10.1111/1754-9485.12184, ISSN: 1754-9485.

Alamanda VK, Moore DC, Song Y, Schwartz HS, Holt GE. Obesity does not affect survival outcomes in extremity soft tissue sarcoma. Clin. Orthop. Relat. Res [print-electronic]. 2014 Sep; 472(9): 2799-806. PMID: 24903824, PMCID: PMC4117870, DOI: 10.1007/s11999-014-3714-7, ISSN: 1528-1132.

Wang XJ, Hartley K, Holt GE, Fadare O, Cates JM. Intracortical schwannoma of the femur. Skeletal Radiol [print-electronic]. 2014 May; 43(5): 687-91. PMID: 24213555, DOI: 10.1007/s00256-013-1758-5, ISSN: 1432-2161.

Dumas JE, Prieto EM, Zienkiewicz KJ, Guda T, Wenke JC, Bible J, Holt GE, Guelcher SA. Balancing the rates of new bone formation and polymer degradation enhances healing of weight-bearing allograft/polyurethane composites in rabbit femoral defects. Tissue Eng Part A [print-electronic]. 2014 Jan; 20(1-2): 115-29. PMID: 23941405, PMCID: PMC3875200, DOI: 10.1089/ten.TEA.2012.0762, ISSN: 1937-335X.

Menge TJ, Hartley KG, Holt GE. Patient-specific imaging and missed tumors: a catastrophic outcome. Am J. Orthop. 2013 Dec; 42(12): 553-6. PMID: 24471144, ISSN: 1934-3418.

Behnke NK, Crosby SN, Stutz CM, Holt GE. Periscapular amputation as treatment for brachial plexopathy secondary to recurrent breast carcinoma: a case series and review of the literature. Eur J Surg Oncol [print-electronic]. 2013 Dec; 39(12): 1325-31. PMID: 24176674, PII: S0748-7983(13)00853-6, DOI: 10.1016/j.ejso.2013.10.005, ISSN: 1532-2157.

Alamanda VK, Delisca GO, Archer KR, Song Y, Schwartz HS, Holt GE. Incomplete excisions of extremity soft tissue sarcomas are unaffected by insurance status or distance from a sarcoma center. J Surg Oncol [print-electronic]. 2013 Dec; 108(7): 477-80. PMID: 24006266, DOI: 10.1002/jso.23427, ISSN: 1096-9098.

Crosby SN, Alamanda VK, Weikert DR, Holt GE. Avoiding unplanned resections of wrist sarcomas: an algorithm for evaluating dorsal wrist masses. Am J. Orthop. 2013 Sep; 42(9): 401-6. PMID: 24078963, ISSN: 1934-3418.

Alamanda VK, Delisca GO, Mathis SL, Archer KR, Ehrenfeld JM, Miller MW, Homlar KC, Halpern JL, Schwartz HS, Holt GE. The financial burden of reexcising incompletely excised soft tissue sarcomas: a cost analysis. Ann. Surg. Oncol [print-electronic]. 2013 Sep; 20(9): 2808-14. PMID: 23636515, DOI: 10.1245/s10434-013-2995-5, ISSN: 1534-4681.

Delisca GO, Alamanda VK, Archer KR, Song Y, Schwartz HS, Holt GE. Tumor size increase following preoperative radiation of soft tissue sarcomas does not affect prognosis. J Surg Oncol [print-electronic]. 2013 Jun; 107(7): 723-7. PMID: 23400806, DOI: 10.1002/jso.23322, ISSN: 1096-9098.

Unruh KP, Dhulipala SC, Holt GE. Patient understanding of the role of the orthopedic resident. J Surg Educ. 2013 May; 70(3): 345-9. PMID: 23618444, PII: S1931-7204(13)00007-X, DOI: 10.1016/j.jsurg.2013.01.004, ISSN: 1878-7452.

Alamanda VK, Crosby SN, Archer KR, Song Y, Schwartz HS, Holt GE. Predictors and clinical significance of local recurrence in extremity soft tissue sarcoma. Acta Oncol [print-electronic]. 2013 May; 52(4): 793-802. PMID: 22877243, DOI: 10.3109/0284186X.2012.711953, ISSN: 1651-226X.

Homlar KC, Sellers MH, Halpern JL, Seeley EH, Holt GE. Serum levels of methyl methacrylate following inhalational exposure to polymethylmethacrylate bone cement. J Arthroplasty [print-electronic]. 2013 Mar; 28(3): 406-9. PMID: 23245392, PII: S0883-5403(12)00530-X, DOI: 10.1016/j.arth.2012.06.038, ISSN: 1532-8406.

Moore DC, Sellers MH, Archer KR, Schwartz HS, Holt GE. Staples equal sutures for skin closure after soft tissue tumor resection. Clin. Orthop. Relat. Res. 2013 Mar; 471(3): 899-904. PMID: 22903280, PMCID: PMC3563796, DOI: 10.1007/s11999-012-2524-z, ISSN: 1528-1132.

Moore DC, Keegan KA, Resnick MJ, Eisenberg R, Holt GE, Cookson MS. A 57-year-old man with a history of prostatectomy and pelvic irradiation presents with recurrent urinary tract infections, hematuria, and pelvic pain. Urology. 2013 Feb; 81(2): 221-5. PMID: 23374762, PMCID: PMC3698486, PII: S0090-4295(12)01300-3, DOI: 10.1016/j.urology.2012.10.037, ISSN: 1527-9995.

Deskins DL, Bastakoty D, Saraswati S, Shinar A, Holt GE, Young PP. Human mesenchymal stromal cells: identifying assays to predict potency for therapeutic selection. Stem Cells Transl Med [print-electronic]. 2013 Feb; 2(2): 151-8. PMID: 23362238, PMCID: PMC3659751, PII: sctm.2012-0099, DOI: 10.5966/sctm.2012-0099, ISSN: 2157-6564.

Alamanda VK, Crosby SN, Mathis SL, Archer KR, Terhune KP, Holt GE. Influence of resident education in correctly diagnosing extremity soft tissue sarcoma. Sarcoma [print-electronic]. 2013; 2013: 679323. PMID: 23710127, PMCID: PMC3654354, DOI: 10.1155/2013/679323, ISSN: 1357-714X.

Hartley KG, Damon BM, Patterson GT, Long JH, Holt GE. MRI techniques: a review and update for the orthopaedic surgeon. J Am Acad Orthop Surg. 2012 Dec; 20(12): 775-87. PMID: 23203937, PII: 20/12/775, DOI: 10.5435/JAAOS-20-12-775, ISSN: 1067-151X.

Mignemi NA, Itani DM, Fasig JH, Keedy VL, Hande KR, Whited BW, Homlar KC, Correa H, Coffin CM, Black JO, Yi Y, Halpern JL, Holt GE, Schwartz HS, Schoenecker JG, Cates JM. Signal transduction pathway analysis in desmoid-type fibromatosis: transforming growth factor-ß, COX2 and sex steroid receptors. Cancer Sci [print-electronic]. 2012 Dec; 103(12): 2173-80. PMID: 23035734, PMCID: PMC4278584, DOI: 10.1111/cas.12037, ISSN: 1349-7006.

Alamanda VK, Crosby SN, Archer KR, Song Y, Schwartz HS, Holt GE. Amputation for extremity soft tissue sarcoma does not increase overall survival: a retrospective cohort study. Eur J Surg Oncol [print-electronic]. 2012 Dec; 38(12): 1178-83. PMID: 22985713, PII: S0748-7983(12)01233-4, DOI: 10.1016/j.ejso.2012.08.024, ISSN: 1532-2157.

Kallen ME, Sanders ME, Gonzalez AL, Black JO, Keedy VL, Hande KR, Homlar KC, Halpern JL, Holt GE, Schwartz HS, Coffin CM, Cates JM. Nuclear p63 expression in osteoblastic tumors. Tumour Biol [print-electronic]. 2012 Oct; 33(5): 1639-44. PMID: 22623071, DOI: 10.1007/s13277-012-0419-y, ISSN: 1423-0380.

Cates JM, Black JO, Itani DM, Fasig JH, Keedy VL, Hande KR, Whited BW, Homlar KC, Halpern JL, Holt GE, Schwartz HS, Coffin CM. Signal transduction pathway analysis in fibromatosis: receptor and nonreceptor tyrosine kinases. Hum. Pathol [print-electronic]. 2012 Oct; 43(10): 1711-8. PMID: 22520949, PMCID: PMC4278590, PII: S0046-8177(11)00530-2, DOI: 10.1016/j.humpath.2011.12.021, ISSN: 1532-8392.

Cates JM, Black J, Wolfe CC, Shinohara ET, Holt GE, Keedy VL, Hande KR, Homlar KC, Halpern JL, Schwartz HS, Troutman A, Coffin CM. Morphologic and immunophenotypic analysis of desmoid-type fibromatosis after radiation therapy. Hum. Pathol [print-electronic]. 2012 Sep; 43(9): 1418-24. PMID: 22404950, PII: S0046-8177(11)00462-X, DOI: 10.1016/j.humpath.2011.11.002, ISSN: 1532-8392.

Menge TJ, Koethe JR, Jenkins CA, Wright PW, Shinar AA, Miller GG, Holt GE. Acute kidney injury after placement of an antibiotic-impregnated cement spacer during revision total knee arthroplasty. J Arthroplasty [print-electronic]. 2012 Jun; 27(6): 1221-7.e1. PMID: 22321301, PII: S0883-5403(11)00683-8, DOI: 10.1016/j.arth.2011.12.005, ISSN: 1532-8406.

Alamanda VK, Crosby SN, Archer KR, Song Y, Schwartz HS, Holt GE. Primary excision compared with re-excision of extremity soft tissue sarcomas--is anything new?. J Surg Oncol [print-electronic]. 2012 Jun 6/1/2012; 105(7): 662-7. PMID: 22213171, DOI: 10.1002/jso.23021, ISSN: 1096-9098.

Ichikawa J, Cole HA, Magnussen RA, Mignemi NA, Butler M, Holt GE, O'Rear L, Yuasa M, Pabla B, Haro H, Cates JM, Hamm HE, Schwartz HS, Schoenecker JG. Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo: procoagulant nature of osteosarcoma. Cancer [print-electronic]. 2012 May 5/1/2012; 118(9): 2494-506. PMID: 21953059, DOI: 10.1002/cncr.26518, ISSN: 1097-0142.

Saraswati S, Deskins DL, Holt GE, Young PP. Pyrvinium, a potent small molecule Wnt inhibitor, increases engraftment and inhibits lineage commitment of mesenchymal stem cells (MSCs). Wound Repair Regen [print-electronic]. 2012 Mar; 20(2): 185-93. PMID: 22332749, PMCID: PMC3303160, DOI: 10.1111/j.1524-475X.2012.00767.x, ISSN: 1524-475X.

Ramo BA, Griffin AM, Gill CS, McDonald DJ, Wunder JS, Ferguson P, Bell RS, Phillips SE, Schwartz HS, Holt GE. Incidence of symptomatic venous thromboembolism in oncologic patients undergoing lower-extremity endoprosthetic arthroplasty. J Bone Joint Surg Am. 2011 May 5/4/2011; 93(9): 847-54. PMID: 21543674, PII: 93/9/847, DOI: 10.2106/JBJS.H.01640, ISSN: 1535-1386.

Crosby SN, Polkowski GG, Schwartz HS, Shinar AA, Holt GE. Metal-backed versus all-polyethylene tibias in megaprostheses of the distal femur. J Arthroplasty [print-electronic]. 2011 Apr; 26(3): 451-7. PMID: 20334995, PII: S0883-5403(10)00014-8, DOI: 10.1016/j.arth.2010.01.007, ISSN: 1532-8406.

Dobbs MD, Lowas SR, Hernanz-Schulman M, Holt GE, Yu C, Kan JH. Impact of abdominopelvic CT on Ewing sarcoma management. Acad Radiol [print-electronic]. 2010 Oct; 17(10): 1288-91. PMID: 20634109, PII: S1076-6332(10)00318-1, DOI: 10.1016/j.acra.2010.06.010, ISSN: 1878-4046.

Cates JM, Friedman DB, Seeley EH, Dupont WD, Schwartz HS, Holt GE, Caprioli RM, Young PP. Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol [print-electronic]. 2010 Aug; 91(4): 335-49. PMID: 20353421, PMCID: PMC2962892, PII: IEP711, DOI: 10.1111/j.1365-2613.2010.00711.x, ISSN: 1365-2613.

Dumas JE, Davis T, Holt GE, Yoshii T, Perrien DS, Nyman JS, Boyce T, Guelcher SA. Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit. Acta Biomater [print-electronic]. 2010 Jul; 6(7): 2394-406. PMID: 20109586, PII: S1742-7061(10)00041-3, DOI: 10.1016/j.actbio.2010.01.030, ISSN: 1878-7568.

Mansour AA, Kelley MC, Hatmaker AR, Holt GE, Schwartz HS. Verification of musculoskeletal FDG-PET-CT findings performed for melanoma staging. Ann. Surg. Oncol [print-electronic]. 2010 Apr; 17(4): 1144-51. PMID: 19967460, DOI: 10.1245/s10434-009-0843-4, ISSN: 1534-4681.

Giannico G, Holt GE, Homlar KC, Johnson J, Pinnt J, Bridge JA. Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. Cancer Genet. Cytogenet. 2009 Dec; 195(2): 168-71. PMID: 19963118, PII: S0165-4608(09)00377-X, DOI: 10.1016/j.cancergencyto.2009.06.024, ISSN: 1873-4456.

Butler MA, Holt GE, Crosby SN, Weikert DR. Late posterior interosseous nerve palsy associated with loosening of radial head implant. J Shoulder Elbow Surg [print-electronic]. 2009 Nov; 18(6): e17-21. PMID: 19487131, PII: S1058-2746(09)00146-3, DOI: 10.1016/j.jse.2009.03.007, ISSN: 1532-6500.

Holt GE, Christie MJ, Schwartz HS. Trabecular metal endoprosthetic limb salvage reconstruction of the lower limb. J Arthroplasty [print-electronic]. 2009 Oct; 24(7): 1079-85. PMID: 18834697, PII: S0883-5403(08)00700-6, DOI: 10.1016/j.arth.2008.08.010, ISSN: 1532-8406.

Thiolloy S, Halpern J, Holt GE, Schwartz HS, Mundy GR, Matrisian LM, Lynch CC. Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res. 2009 Aug 8/15/2009; 69(16): 6747-55. PMID: 19679556, PMCID: PMC2745595, PII: 69/16/6747, DOI: 10.1158/0008-5472.CAN-08-3949, ISSN: 1538-7445.

Herceg ME, Tsiatis AC, Halpern JL, Holt GE, Schwartz HS, Keedy VL, Cates JM. Cyclooxygenase 2 expression in soft tissue leiomyosarcoma. Anticancer Res. 2009 Aug; 29(8): 2913-7. PMID: 19661295, PII: 29/8/2913, ISSN: 1791-7530.

Adelani MA, Stover DG, Halpern JL, Schwartz HS, Holt GE. Caveat arthroplasty. J Arthroplasty [print-electronic]. 2009 Aug; 24(5): 728-34. PMID: 18639434, PII: S0883-5403(08)00470-1, DOI: 10.1016/j.arth.2008.04.030, ISSN: 1532-8406.

Holt GE, Halpern JL, Lynch CC, Devin CJ, Schwartz HS. Imaging analysis of the in vivo bioreactor: a preliminary study. Clin. Orthop. Relat. Res [print-electronic]. 2008 Aug; 466(8): 1890-6. PMID: 18506563, PMCID: PMC2584254, DOI: 10.1007/s11999-008-0295-3, ISSN: 1528-1132.

Adelani MA, Wupperman RM, Holt GE. Benign synovial disorders. J Am Acad Orthop Surg. 2008 May; 16(5): 268-75. PMID: 18460687, PII: 16/5/268, ISSN: 1067-151X.

Adelani MA, Holt GE, Dittus RS, Passman MA, Schwartz HS. Revascularization after segmental resection of lower extremity soft tissue sarcomas. J Surg Oncol. 2007 May 5/1/2007; 95(6): 455-60. PMID: 17458861, DOI: 10.1002/jso.20679, ISSN: 0022-4790.

Holt GE, Schwartz HS, Caldwell RL. Proteomic profiling in musculoskeletal oncology by MALDI mass spectrometry. Clin. Orthop. Relat. Res. 2006 Sep; 450: 105-10. PMID: 16906088, DOI: 10.1097/01.blo.0000229328.68287.93, ISSN: 0009-921X.

Holt GE, Thomson AB, Griffin AM, Bell R, Wunder J, Rougraff B, Schwartz HS. Multifocality and multifocal postradiation sarcomas. Clin. Orthop. Relat. Res. 2006 Sep; 450: 67-75. PMID: 16906076, DOI: 10.1097/01.blo.0000229301.75018.84, ISSN: 0009-921X.

Devin C, Chong PY, Holt GE, Feurer I, Gonzalez A, Merchant N, Schwartz HS. Level-adjusted perioperative risk of sacral amputations. J Surg Oncol. 2006 Sep 9/1/2006; 94(3): 203-11. PMID: 16900511, DOI: 10.1002/jso.20477, ISSN: 0022-4790.

Halpern J, Lynch CC, Fleming J, Hamming D, Martin MD, Schwartz HS, Matrisian LM, Holt GE. The application of a murine bone bioreactor as a model of tumor: bone interaction. Clin. Exp. Metastasis [print-electronic]. 2006; 23(7-8): 345-56. PMID: 17136574, DOI: 10.1007/s10585-006-9044-8, ISSN: 0262-0898.

Holt GE, Halpern JL, Dovan TT, Hamming D, Schwartz HS. Evolution of an in vivo bioreactor. J. Orthop. Res [print-electronic]. 2005 Jul; 23(4): 916-23. PMID: 16023008, PII: S0736-0266(04)00245-1, DOI: 10.1016/j.orthres.2004.10.005, ISSN: 0736-0266.

Holt GE, Griffin AM, Pintilie M, Wunder JS, Catton C, O'Sullivan B, Bell RS. Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. A comparison of high-dose and low-dose radiotherapy. J Bone Joint Surg Am. 2005 Feb; 87(2): 315-9. PMID: 15687153, PII: 87/2/315, DOI: 10.2106/JBJS.C.01714, ISSN: 0021-9355.

Holt GE, Dennis DA. Use of custom triflanged acetabular components in revision total hip arthroplasty. Clin. Orthop. Relat. Res. 2004 Dec; (429): 209-14. PMID: 15577489, PII: 00003086-200412000-00032, ISSN: 0009-921X.

Holt GE, Dennis DA. The role of patellar resurfacing in total knee arthroplasty. Clin. Orthop. Relat. Res. 2003 Nov; (416): 76-83. PMID: 14646743, DOI: 10.1097/01.blo.0000092991.90435.fb, ISSN: 0009-921X.

Holt GE, Mencio GA. Pelvic C-clamp in a pediatric patient. J Orthop Trauma. 2003 Aug; 17(7): 525-7. PMID: 12902792, ISSN: 0890-5339.

Holt GE, McCarty EC. Anterior hip dislocation with an associated vascular injury requiring amputation. J Trauma. 2003 Jul; 55(1): 135-8. PMID: 12855893, DOI: 10.1097/01.TA.0000073996.14689.AF, ISSN: 0022-5282.

Garth WP, DiChristina DG, Holt GE. Chronic Patellofemoral Instability Treated By Proximal Anatomical Repair and Distal Realignment. Clin Orthop. 2000; ((377)): 132-44.

Holt GE, Feurer ID, Schwartz HS. An Analysis of Concordance among Hospital Databases and Physician Records. Annals of Surgical Oncology. 1998; 6((5)): 553-6.

Aarons D, Tong H, Holt G, Poirier G. Acrosome Reaction Induced by Immunoaggregation of a Proteinase Inhibitor Bound to the Murine Sperm Head. Molecular Reproduction and Development. 1991; ((30)): 258-64.