Andre H. Lagrange, Ph.D., M.D.

Associate Professor

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Faculty Appointments
Associate Professor of Neurology
M.D., Oregon Health & Science University, Portland, OregonPh.D., Neuroscience & Neuroendocrinology, Oregon Health & Science University, Portland, OregonB.S., University of Washington, Seattle, Washington
Office Address
6140 MRB III
645 21st Ave South
Nashville, TN 37232-3375
Research Keywords
Epilepsy, Sleep
Arain AM, Azar NJ, Lagrange AH, McLean M, Singh P, Sonmezturk H, Konrad P, Neimat J, Abou-Khalil B. Temporal lobe origin is common in patients who have undergone epilepsy surgery for hypermotor seizures. Epilepsy Behav [print-electronic]. 2016 Nov; 64(Pt A): 57-61. PMID: 27732917, PII: S1525-5050(16)30461-9, DOI: 10.1016/j.yebeh.2016.09.019, ISSN: 1525-5069.

Botzolakis EJ, Gurba KN, Lagrange AH, Feng HJ, Stanic AK, Hu N, Macdonald RL. Comparison of ¿-Aminobutyric Acid, Type A (GABAA), Receptor aß¿ and aßd Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS. J. Biol. Chem [print-electronic]. 2016 Sep 9/23/2016; 291(39): 20440-61. PMID: 27493204, PMCID: PMC5034041, PII: M115.698860, DOI: 10.1074/jbc.M115.698860, ISSN: 1083-351X.

Chen-Block S, Abou-Khalil BW, Arain A, Haas KF, Lagrange AH, Gallagher MJ, Azar NJ, Singh P, Sonmezturk HH. Video-EEG results and clinical characteristics in patients with psychogenic nonepileptic spells: The effect of a coexistent epilepsy. Epilepsy Behav [print-electronic]. 2016 Sep; 62: 62-5. PMID: 27450307, PII: S1525-5050(16)30193-7, DOI: 10.1016/j.yebeh.2016.06.018, ISSN: 1525-5069.

Linane A, Lagrange AH, Fu C, Abou-Khalil B. Generalized onset seizures with focal evolution (GOFE) - A unique seizure type in the setting of generalized epilepsy. Epilepsy Behav [print-electronic]. 2016 Jan; 54: 20-9. PMID: 26619379, PII: S1525-5050(15)00565-X, DOI: 10.1016/j.yebeh.2015.10.005, ISSN: 1525-5069.

Grier MD, Carson RP, Lagrange AH. Of mothers and myelin: Aberrant myelination phenotypes in mouse model of Angelman syndrome are dependent on maternal and dietary influences. Behav. Brain Res [print-electronic]. 2015 Sep 9/15/2015; 291: 260-7. PMID: 26028516, PMCID: PMC4496262, PII: S0166-4328(15)30012-7, DOI: 10.1016/j.bbr.2015.05.045, ISSN: 1872-7549.

Ladner TR, Morgan CD, Pomerantz DJ, Kennedy VE, Azar N, Haas K, Lagrange A, Gallagher M, Singh P, Abou-Khalil BW, Arain AM. Does adherence to epilepsy quality measures correlate with reduced epilepsy-related adverse hospitalizations? A retrospective experience. Epilepsia [print-electronic]. 2015 May; 56(5): e63-7. PMID: 25809720, DOI: 10.1111/epi.12965, ISSN: 1528-1167.

Grier MD, Carson RP, Lagrange AH. Toward a Broader View of Ube3a in a Mouse Model of Angelman Syndrome: Expression in Brain, Spinal Cord, Sciatic Nerve and Glial Cells. PLoS ONE. 2015; 10(4): e0124649. PMID: 25894543, PMCID: PMC4403805, PII: PONE-D-15-02378, DOI: 10.1371/journal.pone.0124649, ISSN: 1932-6203.

Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL. Co-expression of ¿2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor ß2 subunits. Neurochem. Res [print-electronic]. 2014 Jun; 39(6): 1088-103. PMID: 24213971, PMCID: PMC4018433, DOI: 10.1007/s11064-013-1187-9, ISSN: 1573-6903.

Olmez I, Moses H, Sriram S, Kirshner H, Lagrange AH, Pawate S. Diagnostic and therapeutic aspects of Hashimoto's encephalopathy. J. Neurol. Sci [print-electronic]. 2013 Aug 8/15/2013; 331(1-2): 67-71. PMID: 23759502, PII: S0022-510X(13)00216-5, DOI: 10.1016/j.jns.2013.05.009, ISSN: 1878-5883.

Kao C, Forbes JA, Jermakowicz WJ, Sun DA, Davis B, Zhu J, Lagrange AH, Konrad PE. Suppression of thalamocortical oscillations following traumatic brain injury in rats. J. Neurosurg [print-electronic]. 2012 Aug; 117(2): 316-23. PMID: 22631688, DOI: 10.3171/2012.4.JNS111170, ISSN: 1933-0693.

Boursoulian LJ, Schenck CH, Mahowald MW, Lagrange AH. Differentiating parasomnias from nocturnal seizures. J Clin Sleep Med. 2012 Feb 2/15/2012; 8(1): 108-12. PMID: 22334817, PMCID: PMC3266329, DOI: 10.5664/jcsm.1676, ISSN: 1550-9397.

Lo WY, Lagrange AH, Hernandez CC, Harrison R, Dell A, Haslam SM, Sheehan JH, Macdonald RL. Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating. J. Biol. Chem [print-electronic]. 2010 Oct 10/8/2010; 285(41): 31348-61. PMID: 20639197, PMCID: PMC2951209, PII: M110.151449, DOI: 10.1074/jbc.M110.151449, ISSN: 1083-351X.

Azar NJ, Lagrange AH, Wang L, Song Y, Abou-Khalil BW. Transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit--possible relationship to AED tolerance. Epilepsia [print-electronic]. 2010 May; 51(5): 811-7. PMID: 20067500, PII: EPI2494, DOI: 10.1111/j.1528-1167.2009.02494.x, ISSN: 1528-1167.

Williamson R, Hanif S, Mathews GC, Lagrange AH, Abou-Khalil B. Generalized-onset seizures with secondary focal evolution. Epilepsia [print-electronic]. 2009 Jul; 50(7): 1827-32. PMID: 19260942, PII: EPI2045, DOI: 10.1111/j.1528-1167.2009.02045.x, ISSN: 1528-1167.

Azar NJ, Lagrange AH, Abou-Khalil BW. Transitional sharp waves at ictal onset--a neocortical ictal pattern. Clin Neurophysiol [print-electronic]. 2009 Apr; 120(4): 665-72. PMID: 19264545, PII: S1388-2457(09)00031-5, DOI: 10.1016/j.clinph.2009.01.010, ISSN: 1872-8952.

Botzolakis EJ, Maheshwari A, Feng HJ, Lagrange AH, Shaver JH, Kassebaum NJ, Venkataraman R, Baudenbacher F, Macdonald RL. Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics. J. Neurosci. Methods [print-electronic]. 2009 Mar 3/15/2009; 177(2): 294-302. PMID: 19013195, PMCID: PMC3786708, PII: S0165-0270(08)00632-8, DOI: 10.1016/j.jneumeth.2008.10.014, ISSN: 0165-0270.

Lagrange AH. Folic acid supplementation for women with epilepsy who might become pregnant. Nat Clin Pract Neurol. 2009 Jan; 5(1): 16-7. PMID: 19129787, PII: ncpneuro0970, DOI: 10.1038/ncpneuro0970, ISSN: 1745-8358.

Bianchi, MT Botzolakis, EJ Lagrange, AH Macdonald, RL. The Effect of Benzodiazepines on GABAA Receptor Opening Frequency: Differential Modulation Under Synaptic and Extrasynaptic Conditions. Epilepsy Research. 2009; 85: 212-20.

Lagrange, AH. Feeling Out the Elephant in the Room: Why Do Temporal Lobe Seizures Cause Unconsciousness? [editorial]. Epilepsy Currents. 2009; In Press.

Rula EY, Lagrange AH, Jacobs MM, Hu N, Macdonald RL, Emeson RB. Developmental modulation of GABA(A) receptor function by RNA editing. J. Neurosci. 2008 Jun 6/11/2008; 28(24): 6196-201. PMID: 18550761, PMCID: PMC2746000, PII: 28/24/6196, DOI: 10.1523/JNEUROSCI.0443-08.2008, ISSN: 1529-2401.

Harper E, Moses H, Lagrange A. Occult celiac disease presenting as epilepsy and MRI changes that responded to gluten-free diet. Neurology. 2007 Feb 2/13/2007; 68(7): 533-4. PMID: 17296923, PII: 68/7/533, DOI: 10.1212/01.wnl.0000253222.55919.43, ISSN: 1526-632X.

Lagrange AH, Botzolakis EJ, Macdonald RL. Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA. J. Physiol. (Lond.) [print-electronic]. 2007 Feb 2/1/2007; 578(Pt 3): 655-76. PMID: 17124266, PMCID: PMC2151343, PII: jphysiol.2006.122135, DOI: 10.1113/jphysiol.2006.122135, ISSN: 0022-3751.

A.H. Lagrange. Valproate Enhances Neuropeptide Y Expression: Modulating the Modulator [editorial]. Epilepsy Currents. 2007; 7((2)): 23-5.

A.H. Lagrange, P.Pennell. Pregnancy and Seizure Mediations [editorial]. 2007; Hallway Conversations at Epilepsy.Com.

Lee GR, Arain A, Lim N, Lagrange A, Singh P, Abou-Khalil B. Rhythmic ictal nonclonic hand (RINCH) motions: a distinct contralateral sign in temporal lobe epilepsy. Epilepsia. 2006 Dec; 47(12): 2189-92. PMID: 17201723, PII: EPI858, DOI: 10.1111/j.1528-1167.2006.00858.x, ISSN: 0013-9580.

Ma S, Blair MA, Abou-Khalil B, Lagrange AH, Gurnett CA, Hedera P. Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy. Epilepsy Res [print-electronic]. 2006 Oct; 71(2-3): 129-34. PMID: 16839746, PII: S0920-1211(06)00214-2, DOI: 10.1016/j.eplepsyres.2006.06.001, ISSN: 0920-1211.

A.H. Lagrange. Dancing the delta shuffle: Neurosteroids Regulate GABAA Receptor Expression [editorial]. Epilepsy Currents. 2006; 6: 14-7.

A.H. Lagrange. Genetic Variants In Absence Epilepsy: A Contextual Consideration Of Calcium Current Kinetics [editorial]. Epilepsy Currents. 2006; 6((3)): 12-4.

Lagrange, AH. Receptors Gone Bad: The Wrong Place at the Wrong Time [editorial]. Epilepsy Currents. 2005; 5: 91-5.

Lagrange, AH. Retigabine: Bending Potassium Channels To Our Will [editorial]. Epilepsy Current. 2005; 5: 166-9.

Lagrange AH, Blaivas M, Gomez-Hassan D, Malow BA. Rasmussen's syndrome and new-onset narcolepsy, cataplexy, and epilepsy in an adult. Epilepsy Behav. 2003 Dec; 4(6): 788-92. PMID: 14698722, PII: S1525505003002300, ISSN: 1525-5050.

Kelly MJ, Rønnekleiv OK, Ibrahim N, Lagrange AH, Wagner EJ. Estrogen modulation of K(+) channel activity in hypothalamic neurons involved in the control of the reproductive axis. Steroids. 2002 May; 67(6): 447-56. PMID: 11960620, PII: S0039128X01001817, ISSN: 0039-128X.

Kelly MJ, Lagrange AH, Wagner EJ, Rønnekleiv OK. Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids. 1999 Jan; 64(1-2): 64-75. PMID: 10323674, ISSN: 0039-128X.

M.J. Kelly, A.H. Lagrange. Nontranscriptional Effects of Estradiol in Neuropeptide Neurons [editorial]. Curr. Opin. Endo.and Diab. 1998; 55: 66-72.

Piatt JH Jr, Lagrange A. Principles and Practice of Pediatric Neurosurgery. [place unknown: publisher unknown]; 1998.

Lagrange AH, Ronnekleiv OK, Kelly MJ. Modulation of G protein-coupled receptors by an estrogen receptor that activates protein kinase A. Mol. Pharmacol. 1997 Apr; 51(4): 605-12. PMID: 9106625, ISSN: 0026-895X.

Wagner EJ, Zhang G, Lagrange AH, Rønnekleiv OK, Kelly MJ. Tolerance to mu-opioid receptor agonists but not cross-tolerance to gamma-aminobutyric acid(B) receptor agonists in arcuate A12 dopamine neurons with chronic morphine treatment. J. Pharmacol. Exp. Ther. 1997 Feb; 280(2): 1057-64. PMID: 9023324, ISSN: 0022-3565.

Lagrange AH, Wagner EJ, Rønnekleiv OK, Kelly MJ. Estrogen rapidly attenuates a GABAB response in hypothalamic neurons. Neuroendocrinology. 1996 Aug; 64(2): 114-23. PMID: 8857605, ISSN: 0028-3835.

Zhang G, Lagrange AH, Rønnekleiv OK, Kelly MJ. Tolerance of hypothalamic beta-endorphin neurons to mu-opioid receptor activation after chronic morphine. J. Pharmacol. Exp. Ther. 1996 Apr; 277(1): 551-8. PMID: 8613967, ISSN: 0022-3565.

Lagrange AH, Rønnekleiv OK, Kelly MJ. Estradiol-17 beta and mu-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback?. Endocrinology. 1995 May; 136(5): 2341-4. PMID: 7720682, DOI: 10.1210/endo.136.5.7720682, ISSN: 0013-7227.

Kelly, M.J. Lagrange, A.H. Ronnekleiv, O.K.. Estrogen rapidly uncouples mu-opioid receptors from potassium channels via activation of protein kinase A. Analgesia. 1995; 1: 494-7.

Lagrange AH, Ronnekleiv OK, Kelly MJ. The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol. J. Neurosci. 1994 Oct; 14(10): 6196-204. PMID: 7931572, ISSN: 0270-6474.