Faculty Appointments
Associate Professor of Neurology
Education
M.D., Oregon Health & Science University, Portland, OregonPh.D., Neuroscience & Neuroendocrinology, Oregon Health & Science University, Portland, OregonB.S., University of Washington, Seattle, Washington
Office Address
6140 MRB III
645 21st Ave South
Nashville, TN 37232-3375
645 21st Ave South
Nashville, TN 37232-3375
Research Keywords
Epilepsy, Sleep
Publications
Zavalin K, Hassan A, Zhang Y, Khera Z, Lagrange AH. Region and layer-specific expression of GABAA receptor isoforms and KCC2 in developing cortex. Front Cell Neurosci. 2024; 18: 1390742. PMID: 38894703, PMCID: PMC11184147, DOI: 10.3389/fncel.2024.1390742, ISSN: 1662-5102.
Li W, Chen L, Fleming JT, Brignola E, Zavalin K, Lagrange A, Rex T, Heiney SA, Wojaczynski GJ, Medina JF, Chiang C. Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning. J Neurosci [print-electronic]. 2022 Jun 6/29/2022; 42(26): 5130-43. PMID: 35589396, PMCID: PMC9236294, PII: JNEUROSCI.2073-21.2022, DOI: 10.1523/JNEUROSCI.2073-21.2022, ISSN: 1529-2401.
Zavalin K, Hassan A, Fu C, Delpire E, Lagrange AH. Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons. Front Mol Neurosci. 2022; 15: 826427. PMID: 35370549, PMCID: PMC8966887, DOI: 10.3389/fnmol.2022.826427, ISSN: 1662-5099.
Hernandez CC, XiangWei W, Hu N, Shen D, Shen W, Lagrange AH, Zhang Y, Dai L, Ding C, Sun Z, Hu J, Zhu H, Jiang Y, Macdonald RL. Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies. Brain. 2019 Jul 7/1/2019; 142(7): 1938-54. PMID: 31056671, PMCID: PMC6598634, PII: 5485825, DOI: 10.1093/brain/awz123, ISSN: 1460-2156.
Lagrange AH, Hu N, Macdonald RL. GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABAA receptors. J Physiol [print-electronic]. 2018 Sep; 596(18): 4475-95. PMID: 30019335, PMCID: PMC6138284, DOI: 10.1113/JP276187, ISSN: 1469-7793.
Grier MD, West KL, Kelm ND, Fu C, Does MD, Parker B, McBrier E, Lagrange AH, Ess KC, Carson RP. Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination. PLoS One. 2017; 12(11): e0188417. PMID: 29161318, PMCID: PMC5697806, PII: PONE-D-17-24835, DOI: 10.1371/journal.pone.0188417, ISSN: 1932-6203.
Arain AM, Azar NJ, Lagrange AH, McLean M, Singh P, Sonmezturk H, Konrad P, Neimat J, Abou-Khalil B. Temporal lobe origin is common in patients who have undergone epilepsy surgery for hypermotor seizures. Epilepsy Behav [print-electronic]. 2016 Nov; 64(Pt A): 57-61. PMID: 27732917, PII: S1525-5050(16)30461-9, DOI: 10.1016/j.yebeh.2016.09.019, ISSN: 1525-5069.
Botzolakis EJ, Gurba KN, Lagrange AH, Feng HJ, Stanic AK, Hu N, Macdonald RL. Comparison of ¿-Aminobutyric Acid, Type A (GABAA), Receptor aß¿ and aßd Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS. J. Biol. Chem [print-electronic]. 2016 Sep 9/23/2016; 291(39): 20440-61. PMID: 27493204, PMCID: PMC5034041, PII: M115.698860, DOI: 10.1074/jbc.M115.698860, ISSN: 1083-351X.
Chen-Block S, Abou-Khalil BW, Arain A, Haas KF, Lagrange AH, Gallagher MJ, Azar NJ, Singh P, Sonmezturk HH. Video-EEG results and clinical characteristics in patients with psychogenic nonepileptic spells: The effect of a coexistent epilepsy. Epilepsy Behav [print-electronic]. 2016 Sep; 62: 62-5. PMID: 27450307, PII: S1525-5050(16)30193-7, DOI: 10.1016/j.yebeh.2016.06.018, ISSN: 1525-5069.
Linane A, Lagrange AH, Fu C, Abou-Khalil B. Generalized onset seizures with focal evolution (GOFE) - A unique seizure type in the setting of generalized epilepsy. Epilepsy Behav [print-electronic]. 2016 Jan; 54: 20-9. PMID: 26619379, PII: S1525-5050(15)00565-X, DOI: 10.1016/j.yebeh.2015.10.005, ISSN: 1525-5069.
Grier MD, Carson RP, Lagrange AH. Of mothers and myelin: Aberrant myelination phenotypes in mouse model of Angelman syndrome are dependent on maternal and dietary influences. Behav. Brain Res [print-electronic]. 2015 Sep 9/15/2015; 291: 260-7. PMID: 26028516, PMCID: PMC4496262, PII: S0166-4328(15)30012-7, DOI: 10.1016/j.bbr.2015.05.045, ISSN: 1872-7549.
Ladner TR, Morgan CD, Pomerantz DJ, Kennedy VE, Azar N, Haas K, Lagrange A, Gallagher M, Singh P, Abou-Khalil BW, Arain AM. Does adherence to epilepsy quality measures correlate with reduced epilepsy-related adverse hospitalizations? A retrospective experience. Epilepsia [print-electronic]. 2015 May; 56(5): e63-7. PMID: 25809720, DOI: 10.1111/epi.12965, ISSN: 1528-1167.
Grier MD, Carson RP, Lagrange AH. Toward a Broader View of Ube3a in a Mouse Model of Angelman Syndrome: Expression in Brain, Spinal Cord, Sciatic Nerve and Glial Cells. PLoS ONE. 2015; 10(4): e0124649. PMID: 25894543, PMCID: PMC4403805, PII: PONE-D-15-02378, DOI: 10.1371/journal.pone.0124649, ISSN: 1932-6203.
Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL. Co-expression of ¿2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor ß2 subunits. Neurochem. Res [print-electronic]. 2014 Jun; 39(6): 1088-103. PMID: 24213971, PMCID: PMC4018433, DOI: 10.1007/s11064-013-1187-9, ISSN: 1573-6903.
Olmez I, Moses H, Sriram S, Kirshner H, Lagrange AH, Pawate S. Diagnostic and therapeutic aspects of Hashimoto's encephalopathy. J. Neurol. Sci [print-electronic]. 2013 Aug 8/15/2013; 331(1-2): 67-71. PMID: 23759502, PII: S0022-510X(13)00216-5, DOI: 10.1016/j.jns.2013.05.009, ISSN: 1878-5883.
Kao C, Forbes JA, Jermakowicz WJ, Sun DA, Davis B, Zhu J, Lagrange AH, Konrad PE. Suppression of thalamocortical oscillations following traumatic brain injury in rats. J. Neurosurg [print-electronic]. 2012 Aug; 117(2): 316-23. PMID: 22631688, DOI: 10.3171/2012.4.JNS111170, ISSN: 1933-0693.
Boursoulian LJ, Schenck CH, Mahowald MW, Lagrange AH. Differentiating parasomnias from nocturnal seizures. J Clin Sleep Med. 2012 Feb 2/15/2012; 8(1): 108-12. PMID: 22334817, PMCID: PMC3266329, DOI: 10.5664/jcsm.1676, ISSN: 1550-9397.
Lo WY, Lagrange AH, Hernandez CC, Harrison R, Dell A, Haslam SM, Sheehan JH, Macdonald RL. Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating. J. Biol. Chem [print-electronic]. 2010 Oct 10/8/2010; 285(41): 31348-61. PMID: 20639197, PMCID: PMC2951209, PII: M110.151449, DOI: 10.1074/jbc.M110.151449, ISSN: 1083-351X.
Azar NJ, Lagrange AH, Wang L, Song Y, Abou-Khalil BW. Transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit--possible relationship to AED tolerance. Epilepsia [print-electronic]. 2010 May; 51(5): 811-7. PMID: 20067500, PII: EPI2494, DOI: 10.1111/j.1528-1167.2009.02494.x, ISSN: 1528-1167.
Williamson R, Hanif S, Mathews GC, Lagrange AH, Abou-Khalil B. Generalized-onset seizures with secondary focal evolution. Epilepsia [print-electronic]. 2009 Jul; 50(7): 1827-32. PMID: 19260942, PII: EPI2045, DOI: 10.1111/j.1528-1167.2009.02045.x, ISSN: 1528-1167.
Azar NJ, Lagrange AH, Abou-Khalil BW. Transitional sharp waves at ictal onset--a neocortical ictal pattern. Clin Neurophysiol [print-electronic]. 2009 Apr; 120(4): 665-72. PMID: 19264545, PII: S1388-2457(09)00031-5, DOI: 10.1016/j.clinph.2009.01.010, ISSN: 1872-8952.
Botzolakis EJ, Maheshwari A, Feng HJ, Lagrange AH, Shaver JH, Kassebaum NJ, Venkataraman R, Baudenbacher F, Macdonald RL. Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics. J. Neurosci. Methods [print-electronic]. 2009 Mar 3/15/2009; 177(2): 294-302. PMID: 19013195, PMCID: PMC3786708, PII: S0165-0270(08)00632-8, DOI: 10.1016/j.jneumeth.2008.10.014, ISSN: 0165-0270.
Lagrange AH. Folic acid supplementation for women with epilepsy who might become pregnant. Nat Clin Pract Neurol. 2009 Jan; 5(1): 16-7. PMID: 19129787, PII: ncpneuro0970, DOI: 10.1038/ncpneuro0970, ISSN: 1745-8358.
Bianchi, MT Botzolakis, EJ Lagrange, AH Macdonald, RL. The Effect of Benzodiazepines on GABAA Receptor Opening Frequency: Differential Modulation Under Synaptic and Extrasynaptic Conditions. Epilepsy Research. 2009; 85: 212-20.
Lagrange, AH. Feeling Out the Elephant in the Room: Why Do Temporal Lobe Seizures Cause Unconsciousness? [editorial]. Epilepsy Currents. 2009; In Press.
Rula EY, Lagrange AH, Jacobs MM, Hu N, Macdonald RL, Emeson RB. Developmental modulation of GABA(A) receptor function by RNA editing. J. Neurosci. 2008 Jun 6/11/2008; 28(24): 6196-201. PMID: 18550761, PMCID: PMC2746000, PII: 28/24/6196, DOI: 10.1523/JNEUROSCI.0443-08.2008, ISSN: 1529-2401.
Harper E, Moses H, Lagrange A. Occult celiac disease presenting as epilepsy and MRI changes that responded to gluten-free diet. Neurology. 2007 Feb 2/13/2007; 68(7): 533-4. PMID: 17296923, PII: 68/7/533, DOI: 10.1212/01.wnl.0000253222.55919.43, ISSN: 1526-632X.
Lagrange AH, Botzolakis EJ, Macdonald RL. Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA. J. Physiol. (Lond.) [print-electronic]. 2007 Feb 2/1/2007; 578(Pt 3): 655-76. PMID: 17124266, PMCID: PMC2151343, PII: jphysiol.2006.122135, DOI: 10.1113/jphysiol.2006.122135, ISSN: 0022-3751.
A.H. Lagrange. Valproate Enhances Neuropeptide Y Expression: Modulating the Modulator [editorial]. Epilepsy Currents. 2007; 7((2)): 23-5.
A.H. Lagrange, P.Pennell. Pregnancy and Seizure Mediations [editorial]. 2007; Hallway Conversations at Epilepsy.Com.
Lee GR, Arain A, Lim N, Lagrange A, Singh P, Abou-Khalil B. Rhythmic ictal nonclonic hand (RINCH) motions: a distinct contralateral sign in temporal lobe epilepsy. Epilepsia. 2006 Dec; 47(12): 2189-92. PMID: 17201723, PII: EPI858, DOI: 10.1111/j.1528-1167.2006.00858.x, ISSN: 0013-9580.
Ma S, Blair MA, Abou-Khalil B, Lagrange AH, Gurnett CA, Hedera P. Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy. Epilepsy Res [print-electronic]. 2006 Oct; 71(2-3): 129-34. PMID: 16839746, PII: S0920-1211(06)00214-2, DOI: 10.1016/j.eplepsyres.2006.06.001, ISSN: 0920-1211.
A.H. Lagrange. Dancing the delta shuffle: Neurosteroids Regulate GABAA Receptor Expression [editorial]. Epilepsy Currents. 2006; 6: 14-7.
A.H. Lagrange. Genetic Variants In Absence Epilepsy: A Contextual Consideration Of Calcium Current Kinetics [editorial]. Epilepsy Currents. 2006; 6((3)): 12-4.
Lagrange, AH. Receptors Gone Bad: The Wrong Place at the Wrong Time [editorial]. Epilepsy Currents. 2005; 5: 91-5.
Lagrange, AH. Retigabine: Bending Potassium Channels To Our Will [editorial]. Epilepsy Current. 2005; 5: 166-9.
Lagrange AH, Blaivas M, Gomez-Hassan D, Malow BA. Rasmussen's syndrome and new-onset narcolepsy, cataplexy, and epilepsy in an adult. Epilepsy Behav. 2003 Dec; 4(6): 788-92. PMID: 14698722, PII: S1525505003002300, ISSN: 1525-5050.
Kelly MJ, Rønnekleiv OK, Ibrahim N, Lagrange AH, Wagner EJ. Estrogen modulation of K(+) channel activity in hypothalamic neurons involved in the control of the reproductive axis. Steroids. 2002 May; 67(6): 447-56. PMID: 11960620, PII: S0039128X01001817, ISSN: 0039-128X.
Kelly MJ, Lagrange AH, Wagner EJ, Rønnekleiv OK. Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids. 1999 Jan; 64(1-2): 64-75. PMID: 10323674, ISSN: 0039-128X.
M.J. Kelly, A.H. Lagrange. Nontranscriptional Effects of Estradiol in Neuropeptide Neurons [editorial]. Curr. Opin. Endo.and Diab. 1998; 55: 66-72.
Piatt JH Jr, Lagrange A. Principles and Practice of Pediatric Neurosurgery. [place unknown: publisher unknown]; 1998.
Lagrange AH, Ronnekleiv OK, Kelly MJ. Modulation of G protein-coupled receptors by an estrogen receptor that activates protein kinase A. Mol. Pharmacol. 1997 Apr; 51(4): 605-12. PMID: 9106625, ISSN: 0026-895X.
Wagner EJ, Zhang G, Lagrange AH, Rønnekleiv OK, Kelly MJ. Tolerance to mu-opioid receptor agonists but not cross-tolerance to gamma-aminobutyric acid(B) receptor agonists in arcuate A12 dopamine neurons with chronic morphine treatment. J. Pharmacol. Exp. Ther. 1997 Feb; 280(2): 1057-64. PMID: 9023324, ISSN: 0022-3565.
Lagrange AH, Wagner EJ, Rønnekleiv OK, Kelly MJ. Estrogen rapidly attenuates a GABAB response in hypothalamic neurons. Neuroendocrinology. 1996 Aug; 64(2): 114-23. PMID: 8857605, ISSN: 0028-3835.
Zhang G, Lagrange AH, Rønnekleiv OK, Kelly MJ. Tolerance of hypothalamic beta-endorphin neurons to mu-opioid receptor activation after chronic morphine. J. Pharmacol. Exp. Ther. 1996 Apr; 277(1): 551-8. PMID: 8613967, ISSN: 0022-3565.
Lagrange AH, Rønnekleiv OK, Kelly MJ. Estradiol-17 beta and mu-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback?. Endocrinology. 1995 May; 136(5): 2341-4. PMID: 7720682, DOI: 10.1210/endo.136.5.7720682, ISSN: 0013-7227.
Kelly, M.J. Lagrange, A.H. Ronnekleiv, O.K.. Estrogen rapidly uncouples mu-opioid receptors from potassium channels via activation of protein kinase A. Analgesia. 1995; 1: 494-7.
Lagrange AH, Ronnekleiv OK, Kelly MJ. The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol. J. Neurosci. 1994 Oct; 14(10): 6196-204. PMID: 7931572, ISSN: 0270-6474.
Li W, Chen L, Fleming JT, Brignola E, Zavalin K, Lagrange A, Rex T, Heiney SA, Wojaczynski GJ, Medina JF, Chiang C. Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning. J Neurosci [print-electronic]. 2022 Jun 6/29/2022; 42(26): 5130-43. PMID: 35589396, PMCID: PMC9236294, PII: JNEUROSCI.2073-21.2022, DOI: 10.1523/JNEUROSCI.2073-21.2022, ISSN: 1529-2401.
Zavalin K, Hassan A, Fu C, Delpire E, Lagrange AH. Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons. Front Mol Neurosci. 2022; 15: 826427. PMID: 35370549, PMCID: PMC8966887, DOI: 10.3389/fnmol.2022.826427, ISSN: 1662-5099.
Hernandez CC, XiangWei W, Hu N, Shen D, Shen W, Lagrange AH, Zhang Y, Dai L, Ding C, Sun Z, Hu J, Zhu H, Jiang Y, Macdonald RL. Altered inhibitory synapses in de novo GABRA5 and GABRA1 mutations associated with early onset epileptic encephalopathies. Brain. 2019 Jul 7/1/2019; 142(7): 1938-54. PMID: 31056671, PMCID: PMC6598634, PII: 5485825, DOI: 10.1093/brain/awz123, ISSN: 1460-2156.
Lagrange AH, Hu N, Macdonald RL. GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABAA receptors. J Physiol [print-electronic]. 2018 Sep; 596(18): 4475-95. PMID: 30019335, PMCID: PMC6138284, DOI: 10.1113/JP276187, ISSN: 1469-7793.
Grier MD, West KL, Kelm ND, Fu C, Does MD, Parker B, McBrier E, Lagrange AH, Ess KC, Carson RP. Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination. PLoS One. 2017; 12(11): e0188417. PMID: 29161318, PMCID: PMC5697806, PII: PONE-D-17-24835, DOI: 10.1371/journal.pone.0188417, ISSN: 1932-6203.
Arain AM, Azar NJ, Lagrange AH, McLean M, Singh P, Sonmezturk H, Konrad P, Neimat J, Abou-Khalil B. Temporal lobe origin is common in patients who have undergone epilepsy surgery for hypermotor seizures. Epilepsy Behav [print-electronic]. 2016 Nov; 64(Pt A): 57-61. PMID: 27732917, PII: S1525-5050(16)30461-9, DOI: 10.1016/j.yebeh.2016.09.019, ISSN: 1525-5069.
Botzolakis EJ, Gurba KN, Lagrange AH, Feng HJ, Stanic AK, Hu N, Macdonald RL. Comparison of ¿-Aminobutyric Acid, Type A (GABAA), Receptor aß¿ and aßd Expression Using Flow Cytometry and Electrophysiology: EVIDENCE FOR ALTERNATIVE SUBUNIT STOICHIOMETRIES AND ARRANGEMENTS. J. Biol. Chem [print-electronic]. 2016 Sep 9/23/2016; 291(39): 20440-61. PMID: 27493204, PMCID: PMC5034041, PII: M115.698860, DOI: 10.1074/jbc.M115.698860, ISSN: 1083-351X.
Chen-Block S, Abou-Khalil BW, Arain A, Haas KF, Lagrange AH, Gallagher MJ, Azar NJ, Singh P, Sonmezturk HH. Video-EEG results and clinical characteristics in patients with psychogenic nonepileptic spells: The effect of a coexistent epilepsy. Epilepsy Behav [print-electronic]. 2016 Sep; 62: 62-5. PMID: 27450307, PII: S1525-5050(16)30193-7, DOI: 10.1016/j.yebeh.2016.06.018, ISSN: 1525-5069.
Linane A, Lagrange AH, Fu C, Abou-Khalil B. Generalized onset seizures with focal evolution (GOFE) - A unique seizure type in the setting of generalized epilepsy. Epilepsy Behav [print-electronic]. 2016 Jan; 54: 20-9. PMID: 26619379, PII: S1525-5050(15)00565-X, DOI: 10.1016/j.yebeh.2015.10.005, ISSN: 1525-5069.
Grier MD, Carson RP, Lagrange AH. Of mothers and myelin: Aberrant myelination phenotypes in mouse model of Angelman syndrome are dependent on maternal and dietary influences. Behav. Brain Res [print-electronic]. 2015 Sep 9/15/2015; 291: 260-7. PMID: 26028516, PMCID: PMC4496262, PII: S0166-4328(15)30012-7, DOI: 10.1016/j.bbr.2015.05.045, ISSN: 1872-7549.
Ladner TR, Morgan CD, Pomerantz DJ, Kennedy VE, Azar N, Haas K, Lagrange A, Gallagher M, Singh P, Abou-Khalil BW, Arain AM. Does adherence to epilepsy quality measures correlate with reduced epilepsy-related adverse hospitalizations? A retrospective experience. Epilepsia [print-electronic]. 2015 May; 56(5): e63-7. PMID: 25809720, DOI: 10.1111/epi.12965, ISSN: 1528-1167.
Grier MD, Carson RP, Lagrange AH. Toward a Broader View of Ube3a in a Mouse Model of Angelman Syndrome: Expression in Brain, Spinal Cord, Sciatic Nerve and Glial Cells. PLoS ONE. 2015; 10(4): e0124649. PMID: 25894543, PMCID: PMC4403805, PII: PONE-D-15-02378, DOI: 10.1371/journal.pone.0124649, ISSN: 1932-6203.
Lo WY, Lagrange AH, Hernandez CC, Gurba KN, Macdonald RL. Co-expression of ¿2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor ß2 subunits. Neurochem. Res [print-electronic]. 2014 Jun; 39(6): 1088-103. PMID: 24213971, PMCID: PMC4018433, DOI: 10.1007/s11064-013-1187-9, ISSN: 1573-6903.
Olmez I, Moses H, Sriram S, Kirshner H, Lagrange AH, Pawate S. Diagnostic and therapeutic aspects of Hashimoto's encephalopathy. J. Neurol. Sci [print-electronic]. 2013 Aug 8/15/2013; 331(1-2): 67-71. PMID: 23759502, PII: S0022-510X(13)00216-5, DOI: 10.1016/j.jns.2013.05.009, ISSN: 1878-5883.
Kao C, Forbes JA, Jermakowicz WJ, Sun DA, Davis B, Zhu J, Lagrange AH, Konrad PE. Suppression of thalamocortical oscillations following traumatic brain injury in rats. J. Neurosurg [print-electronic]. 2012 Aug; 117(2): 316-23. PMID: 22631688, DOI: 10.3171/2012.4.JNS111170, ISSN: 1933-0693.
Boursoulian LJ, Schenck CH, Mahowald MW, Lagrange AH. Differentiating parasomnias from nocturnal seizures. J Clin Sleep Med. 2012 Feb 2/15/2012; 8(1): 108-12. PMID: 22334817, PMCID: PMC3266329, DOI: 10.5664/jcsm.1676, ISSN: 1550-9397.
Lo WY, Lagrange AH, Hernandez CC, Harrison R, Dell A, Haslam SM, Sheehan JH, Macdonald RL. Glycosylation of {beta}2 subunits regulates GABAA receptor biogenesis and channel gating. J. Biol. Chem [print-electronic]. 2010 Oct 10/8/2010; 285(41): 31348-61. PMID: 20639197, PMCID: PMC2951209, PII: M110.151449, DOI: 10.1074/jbc.M110.151449, ISSN: 1083-351X.
Azar NJ, Lagrange AH, Wang L, Song Y, Abou-Khalil BW. Transient improvement after brief antiepileptic drug withdrawal in the epilepsy monitoring unit--possible relationship to AED tolerance. Epilepsia [print-electronic]. 2010 May; 51(5): 811-7. PMID: 20067500, PII: EPI2494, DOI: 10.1111/j.1528-1167.2009.02494.x, ISSN: 1528-1167.
Williamson R, Hanif S, Mathews GC, Lagrange AH, Abou-Khalil B. Generalized-onset seizures with secondary focal evolution. Epilepsia [print-electronic]. 2009 Jul; 50(7): 1827-32. PMID: 19260942, PII: EPI2045, DOI: 10.1111/j.1528-1167.2009.02045.x, ISSN: 1528-1167.
Azar NJ, Lagrange AH, Abou-Khalil BW. Transitional sharp waves at ictal onset--a neocortical ictal pattern. Clin Neurophysiol [print-electronic]. 2009 Apr; 120(4): 665-72. PMID: 19264545, PII: S1388-2457(09)00031-5, DOI: 10.1016/j.clinph.2009.01.010, ISSN: 1872-8952.
Botzolakis EJ, Maheshwari A, Feng HJ, Lagrange AH, Shaver JH, Kassebaum NJ, Venkataraman R, Baudenbacher F, Macdonald RL. Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics. J. Neurosci. Methods [print-electronic]. 2009 Mar 3/15/2009; 177(2): 294-302. PMID: 19013195, PMCID: PMC3786708, PII: S0165-0270(08)00632-8, DOI: 10.1016/j.jneumeth.2008.10.014, ISSN: 0165-0270.
Lagrange AH. Folic acid supplementation for women with epilepsy who might become pregnant. Nat Clin Pract Neurol. 2009 Jan; 5(1): 16-7. PMID: 19129787, PII: ncpneuro0970, DOI: 10.1038/ncpneuro0970, ISSN: 1745-8358.
Bianchi, MT Botzolakis, EJ Lagrange, AH Macdonald, RL. The Effect of Benzodiazepines on GABAA Receptor Opening Frequency: Differential Modulation Under Synaptic and Extrasynaptic Conditions. Epilepsy Research. 2009; 85: 212-20.
Lagrange, AH. Feeling Out the Elephant in the Room: Why Do Temporal Lobe Seizures Cause Unconsciousness? [editorial]. Epilepsy Currents. 2009; In Press.
Rula EY, Lagrange AH, Jacobs MM, Hu N, Macdonald RL, Emeson RB. Developmental modulation of GABA(A) receptor function by RNA editing. J. Neurosci. 2008 Jun 6/11/2008; 28(24): 6196-201. PMID: 18550761, PMCID: PMC2746000, PII: 28/24/6196, DOI: 10.1523/JNEUROSCI.0443-08.2008, ISSN: 1529-2401.
Harper E, Moses H, Lagrange A. Occult celiac disease presenting as epilepsy and MRI changes that responded to gluten-free diet. Neurology. 2007 Feb 2/13/2007; 68(7): 533-4. PMID: 17296923, PII: 68/7/533, DOI: 10.1212/01.wnl.0000253222.55919.43, ISSN: 1526-632X.
Lagrange AH, Botzolakis EJ, Macdonald RL. Enhanced macroscopic desensitization shapes the response of alpha4 subtype-containing GABAA receptors to synaptic and extrasynaptic GABA. J. Physiol. (Lond.) [print-electronic]. 2007 Feb 2/1/2007; 578(Pt 3): 655-76. PMID: 17124266, PMCID: PMC2151343, PII: jphysiol.2006.122135, DOI: 10.1113/jphysiol.2006.122135, ISSN: 0022-3751.
A.H. Lagrange. Valproate Enhances Neuropeptide Y Expression: Modulating the Modulator [editorial]. Epilepsy Currents. 2007; 7((2)): 23-5.
A.H. Lagrange, P.Pennell. Pregnancy and Seizure Mediations [editorial]. 2007; Hallway Conversations at Epilepsy.Com.
Lee GR, Arain A, Lim N, Lagrange A, Singh P, Abou-Khalil B. Rhythmic ictal nonclonic hand (RINCH) motions: a distinct contralateral sign in temporal lobe epilepsy. Epilepsia. 2006 Dec; 47(12): 2189-92. PMID: 17201723, PII: EPI858, DOI: 10.1111/j.1528-1167.2006.00858.x, ISSN: 0013-9580.
Ma S, Blair MA, Abou-Khalil B, Lagrange AH, Gurnett CA, Hedera P. Mutations in the GABRA1 and EFHC1 genes are rare in familial juvenile myoclonic epilepsy. Epilepsy Res [print-electronic]. 2006 Oct; 71(2-3): 129-34. PMID: 16839746, PII: S0920-1211(06)00214-2, DOI: 10.1016/j.eplepsyres.2006.06.001, ISSN: 0920-1211.
A.H. Lagrange. Dancing the delta shuffle: Neurosteroids Regulate GABAA Receptor Expression [editorial]. Epilepsy Currents. 2006; 6: 14-7.
A.H. Lagrange. Genetic Variants In Absence Epilepsy: A Contextual Consideration Of Calcium Current Kinetics [editorial]. Epilepsy Currents. 2006; 6((3)): 12-4.
Lagrange, AH. Receptors Gone Bad: The Wrong Place at the Wrong Time [editorial]. Epilepsy Currents. 2005; 5: 91-5.
Lagrange, AH. Retigabine: Bending Potassium Channels To Our Will [editorial]. Epilepsy Current. 2005; 5: 166-9.
Lagrange AH, Blaivas M, Gomez-Hassan D, Malow BA. Rasmussen's syndrome and new-onset narcolepsy, cataplexy, and epilepsy in an adult. Epilepsy Behav. 2003 Dec; 4(6): 788-92. PMID: 14698722, PII: S1525505003002300, ISSN: 1525-5050.
Kelly MJ, Rønnekleiv OK, Ibrahim N, Lagrange AH, Wagner EJ. Estrogen modulation of K(+) channel activity in hypothalamic neurons involved in the control of the reproductive axis. Steroids. 2002 May; 67(6): 447-56. PMID: 11960620, PII: S0039128X01001817, ISSN: 0039-128X.
Kelly MJ, Lagrange AH, Wagner EJ, Rønnekleiv OK. Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids. 1999 Jan; 64(1-2): 64-75. PMID: 10323674, ISSN: 0039-128X.
M.J. Kelly, A.H. Lagrange. Nontranscriptional Effects of Estradiol in Neuropeptide Neurons [editorial]. Curr. Opin. Endo.and Diab. 1998; 55: 66-72.
Piatt JH Jr, Lagrange A. Principles and Practice of Pediatric Neurosurgery. [place unknown: publisher unknown]; 1998.
Lagrange AH, Ronnekleiv OK, Kelly MJ. Modulation of G protein-coupled receptors by an estrogen receptor that activates protein kinase A. Mol. Pharmacol. 1997 Apr; 51(4): 605-12. PMID: 9106625, ISSN: 0026-895X.
Wagner EJ, Zhang G, Lagrange AH, Rønnekleiv OK, Kelly MJ. Tolerance to mu-opioid receptor agonists but not cross-tolerance to gamma-aminobutyric acid(B) receptor agonists in arcuate A12 dopamine neurons with chronic morphine treatment. J. Pharmacol. Exp. Ther. 1997 Feb; 280(2): 1057-64. PMID: 9023324, ISSN: 0022-3565.
Lagrange AH, Wagner EJ, Rønnekleiv OK, Kelly MJ. Estrogen rapidly attenuates a GABAB response in hypothalamic neurons. Neuroendocrinology. 1996 Aug; 64(2): 114-23. PMID: 8857605, ISSN: 0028-3835.
Zhang G, Lagrange AH, Rønnekleiv OK, Kelly MJ. Tolerance of hypothalamic beta-endorphin neurons to mu-opioid receptor activation after chronic morphine. J. Pharmacol. Exp. Ther. 1996 Apr; 277(1): 551-8. PMID: 8613967, ISSN: 0022-3565.
Lagrange AH, Rønnekleiv OK, Kelly MJ. Estradiol-17 beta and mu-opioid peptides rapidly hyperpolarize GnRH neurons: a cellular mechanism of negative feedback?. Endocrinology. 1995 May; 136(5): 2341-4. PMID: 7720682, DOI: 10.1210/endo.136.5.7720682, ISSN: 0013-7227.
Kelly, M.J. Lagrange, A.H. Ronnekleiv, O.K.. Estrogen rapidly uncouples mu-opioid receptors from potassium channels via activation of protein kinase A. Analgesia. 1995; 1: 494-7.
Lagrange AH, Ronnekleiv OK, Kelly MJ. The potency of mu-opioid hyperpolarization of hypothalamic arcuate neurons is rapidly attenuated by 17 beta-estradiol. J. Neurosci. 1994 Oct; 14(10): 6196-204. PMID: 7931572, ISSN: 0270-6474.