Prince J. Kannankeril, M.D.

Faculty Appointments
Professor of Pediatrics The Richard B. Johnston, Jr, M.D. Chair in Pediatric Research, Cardiology
M.S.C.I., Clinical Investigation , Vanderbilt University, Nashville, TennesseeM.D., Thomas Jefferson University, Jefferson Medical College, Philadelphia, PennsylvaniaB.S., Pennsylvania State University, University Park, Pennsylvania
Office Address
Suite 5230 DOT
2200 Children's Way
Nashville, TN 2572
Watanabe H, Makiyama T, Koyama T, Kannankeril PJ, Seto S, Okamura K, Oda H, Itoh H, Okada M, Tanabe N, Yagihara N, Kamakura S, Horie M, Aizawa Y, Shimizu W. High prevalence of early repolarization in short QT syndrome. Heart Rhythm [print-electronic]. 2010 May; 7(5): 647-52. PMID: 20206319, PII: S1547-5271(10)00034-2, DOI: 10.1016/j.hrthm.2010.01.012, ISSN: 1556-3871.

Kannankeril PJ, Bonney WJ, Dzurik MV, Fish FA. Entrainment to distinguish orthodromic reciprocating tachycardia from atrioventricular nodal reentry tachycardia in children. Pacing Clin Electrophysiol [print-electronic]. 2010 Apr; 33(4): 469-74. PMID: 20015126, PII: PACE2639, DOI: 10.1111/j.1540-8159.2009.02639.x, ISSN: 1540-8159.

Watanabe H, Kaiser DW, Makino S, MacRae CA, Ellinor PT, Wasserman BS, Kannankeril PJ, Donahue BS, Roden DM, Darbar D. ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling. Heart Rhythm [print-electronic]. 2009 Sep; 6(9): 1327-32. PMID: 19648063, PMCID: PMC2740737, PII: S1547-5271(09)00524-4, DOI: 10.1016/j.hrthm.2009.05.014, ISSN: 1556-3871.

Chicos AB, Kannankeril PJ, Kadish AH, Goldberger JJ. Parasympathetic effects on cardiac electrophysiology during exercise and recovery in patients with left ventricular dysfunction. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2009 Aug; 297(2): H743-9. PMID: 19525382, PMCID: PMC2724198, PII: 00193.2009, DOI: 10.1152/ajpheart.00193.2009, ISSN: 1522-1539.

Villafane J, Young ML, Maury P, Wolpert C, Anttonen O, Hamilton R, Kannankeril PJ, Fischbach PS. Short QT syndrome in a pediatric patient. Pediatr Cardiol [print-electronic]. 2009 Aug; 30(6): 846-50. PMID: 19365654, DOI: 10.1007/s00246-009-9439-9, ISSN: 1432-1971.

Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM. Mutations in sodium channel ß1- and ß2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol [print-electronic]. 2009 Jun; 2(3): 268-75. PMID: 19808477, PMCID: PMC2727725, PII: CIRCEP.108.779181, DOI: 10.1161/CIRCEP.108.779181, ISSN: 1941-3084.

Kääb S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, Lunetta KL, Larson MG, Levy D, MacRae CA, Ruskin JN, Wacker A, Schömig A, Wichmann HE, Steinbeck G, Meitinger T, Uitterlinden AG, Witteman JC, Roden DM, Benjamin EJ, Ellinor PT. Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Eur. Heart J [print-electronic]. 2009 Apr; 30(7): 813-9. PMID: 19141561, PMCID: PMC2663727, PII: ehn578, DOI: 10.1093/eurheartj/ehn578, ISSN: 1522-9645.

Kannankeril PJ, Harris PA, Norris KJ, Warsy I, Smith PD, Roden DM. Rate-independent QT shortening during exercise in healthy subjects: terminal repolarization does not shorten with exercise. J. Cardiovasc. Electrophysiol [print-electronic]. 2008 Dec; 19(12): 1284-8. PMID: 18665873, PMCID: PMC2811883, PII: JCE1266, DOI: 10.1111/j.1540-8167.2008.01266.x, ISSN: 1540-8167.

Lahiri MK, Kannankeril PJ, Goldberger JJ. Assessment of autonomic function in cardiovascular disease: physiological basis and prognostic implications. J. Am. Coll. Cardiol. 2008 May 5/6/2008; 51(18): 1725-33. PMID: 18452777, PII: S0735-1097(08)00695-5, DOI: 10.1016/j.jacc.2008.01.038, ISSN: 1558-3597.

Kannankeril PJ. Understanding drug-induced torsades de pointes: a genetic stance. Expert Opin Drug Saf. 2008 May; 7(3): 231-9. PMID: 18462182, DOI: 10.1517/14740338.7.3.231, ISSN: 1744-764X.

Darbar D, Kannankeril PJ, Donahue BS, Kucera G, Stubblefield T, Haines JL, George AL, Roden DM. Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation [print-electronic]. 2008 Apr 4/15/2008; 117(15): 1927-35. PMID: 18378609, PMCID: PMC2365761, PII: CIRCULATIONAHA.107.757955, DOI: 10.1161/CIRCULATIONAHA.107.757955, ISSN: 1524-4539.

Chopra N, Kannankeril PJ, Yang T, Hlaing T, Holinstat I, Ettensohn K, Pfeifer K, Akin B, Jones LR, Franzini-Armstrong C, Knollmann BC. Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice. Circ. Res [print-electronic]. 2007 Sep 9/14/2007; 101(6): 617-26. PMID: 17656677, PII: CIRCRESAHA.107.157552, DOI: 10.1161/CIRCRESAHA.107.157552, ISSN: 1524-4571.

Roden DM, Kannankeril P, Darbar D. On the relationship among QT interval, atrial fibrillation, and torsade de pointes. Europace. 2007 Sep; 9 Suppl 4: iv1-3. PMID: 17766319, PMCID: PMC2599908, PII: 9/suppl_4/iv1, DOI: 10.1093/europace/eum165, ISSN: 1099-5129.

Smith AH, Norris KJ, Roden DM, Kannankeril PJ. Autonomic tone attenuates drug-induced QT prolongation. J. Cardiovasc. Electrophysiol [print-electronic]. 2007 Sep; 18(9): 960-4. PMID: 17666066, PII: JCE901, DOI: 10.1111/j.1540-8167.2007.00901.x, ISSN: 1540-8167.

Werdich AA, Baudenbacher F, Dzhura I, Jeyakumar LH, Kannankeril PJ, Fleischer S, LeGrone A, Milatovic D, Aschner M, Strauss AW, Anderson ME, Exil VJ. Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2007 May; 292(5): H2202-11. PMID: 17209005, PII: 00382.2006, DOI: 10.1152/ajpheart.00382.2006, ISSN: 0363-6135.

Kannankeril PJ, Roden DM. When should QT be measured? Summer solstice or Christmas Eve? [editorial]. Heart Rhythm [print-electronic]. 2007 Mar; 4(3): 282-3. PMID: 17341388, PII: S1547-5271(06)02225-9, DOI: 10.1016/j.hrthm.2006.11.027, ISSN: 1547-5271.

Kannankeril PJ, Roden DM. Drug-induced long QT and torsade de pointes: recent advances. Curr. Opin. Cardiol. 2007 Jan; 22(1): 39-43. PMID: 17143043, PII: 00001573-200701000-00008, DOI: 10.1097/HCO.0b013e32801129eb, ISSN: 0268-4705.

Khoo MS, Li J, Singh MV, Yang Y, Kannankeril P, Wu Y, Grueter CE, Guan X, Oddis CV, Zhang R, Mendes L, Ni G, Madu EC, Yang J, Bass M, Gomez RJ, Wadzinski BE, Olson EN, Colbran RJ, Anderson ME. Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy. Circulation [print-electronic]. 2006 Sep 9/26/2006; 114(13): 1352-9. PMID: 16982937, PII: CIRCULATIONAHA.106.644583, DOI: 10.1161/CIRCULATIONAHA.106.644583, ISSN: 1524-4539.

Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Aug 8/8/2006; 103(32): 12179-84. PMID: 16873551, PMCID: PMC1567715, PII: 0600268103, DOI: 10.1073/pnas.0600268103, ISSN: 0027-8424.

Kannankeril PJ, Bhuiyan ZA, Darbar D, Mannens MM, Wilde AA, Roden DM. Arrhythmogenic right ventricular cardiomyopathy due to a novel plakophilin 2 mutation: wide spectrum of disease in mutation carriers within a family. Heart Rhythm [print-electronic]. 2006 Aug; 3(8): 939-44. PMID: 16876743, PII: S1547-5271(06)01485-8, DOI: 10.1016/j.hrthm.2006.04.028, ISSN: 1547-5271.

Kannankeril PJ, Fish FA. Sustained slow pathway conduction: superior to dual atrioventricular node physiology in young patients with atrioventricular nodal reentry tachycardia?. Pacing Clin Electrophysiol. 2006 Feb; 29(2): 159-63. PMID: 16492301, PII: PACE310, DOI: 10.1111/j.1540-8159.2006.00310.x, ISSN: 0147-8389.

Smith AH, Fish FA, Kannankeril PJ. Andersen-Tawil syndrome. Indian Pacing Electrophysiol J. 2006; 6(1): 32-43. PMID: 16943893, PMCID: PMC1501096, ISSN: 0972-6292.

Khoo MS, Kannankeril PJ, Li J, Zhang R, Kupershmidt S, Zhang W, Atkinson JB, Colbran RJ, Roden DM, Anderson ME. Calmodulin kinase II activity is required for normal atrioventricular nodal conduction. Heart Rhythm. 2005 Jun; 2(6): 634-40. PMID: 15922273, PII: S1547-5271(05)01441-4, DOI: 10.1016/j.hrthm.2005.03.019, ISSN: 1547-5271.

Haque A, Kannankeril PJ. Respiratory distress in a young infant. Clin Pediatr (Phila). 2005 May; 44(4): 367-9. PMID: 15864373, ISSN: 0009-9228.

Todd SJ, Campbell MJ, Roden DM, Kannankeril PJ. Novel Brugada SCN5A mutation causing sudden death in children. Heart Rhythm. 2005 May; 2(5): 540-3. PMID: 15840483, PII: S1547-5271(05)00201-8, DOI: 10.1016/j.hrthm.2005.01.029, ISSN: 1547-5271.

Kannankeril PJ, Fish FA. Management of intra-atrial reentrant tachycardia. Curr. Opin. Cardiol. 2005 Mar; 20(2): 89-93. PMID: 15711193, PII: 00001573-200503000-00005, ISSN: 0268-4705.

Kannankeril PJ, Roden DM, Norris KJ, Whalen SP, George AL, Murray KT. Genetic susceptibility to acquired long QT syndrome: pharmacologic challenge in first-degree relatives. Heart Rhythm. 2005 Feb; 2(2): 134-40. PMID: 15851285, PII: S1547-5271(04)00777-5, DOI: 10.1016/j.hrthm.2004.10.039, ISSN: 1547-5271.

Kannankeril PJ, Bibeau DA, Fish FA. Feasibility of the inframammary location for insertable loop recorders in young women and girls. Pacing Clin Electrophysiol. 2004 Apr; 27(4): 492-4. PMID: 15078403, PII: PACE469, DOI: 10.1111/j.1540-8159.2004.00469.x, ISSN: 0147-8389.

Kannankeril PJ, Roden DM, Fish FA. Suppression of bidirectional ventricular tachycardia and unmasking of prolonged QT interval with verapamil in Andersen's syndrome. J. Cardiovasc. Electrophysiol. 2004 Jan; 15(1): 119. PMID: 15028088, PII: JCE03369, DOI: 10.1046/j.1540-8167.2004.03369.x, ISSN: 1045-3873.

Kannankeril PJ, Anderson ME, Rottman JN, Wathen MS, Fish FA. Frequency of late recurrence of intra-atrial reentry tachycardia after radiofrequency catheter ablation in patients with congenital heart disease. Am. J. Cardiol. 2003 Oct 10/1/2003; 92(7): 879-81. PMID: 14516900, PII: S0002914903009081, ISSN: 0002-9149.

Kannankeril PJ, Johns JA, Fish FA. Inducible atrioventricular nodal reentry tachycardia in infants with a history of neonatal orthodromic reciprocating tachycardia. Pacing Clin Electrophysiol. 2003 Aug; 26(8): 1735-7. PMID: 12877708, PII: 260, ISSN: 0147-8389.

Kannankeril PJ, Gotteiner NL, Deal BJ, Johnsrude CL, Strasburger JF. Location of accessory connection in infants presenting with supraventricular tachycardia in utero: clinical correlations. Am J Perinatol. 2003 Apr; 20(3): 115-9. PMID: 12802710, DOI: 10.1055/s-2003-40014, ISSN: 0735-1631.

Kannankeril PJ, Pahl E, Wax DF. Usefulness of troponin I as a marker of myocardial injury after pediatric cardiac catheterization. Am. J. Cardiol. 2002 Nov 11/15/2002; 90(10): 1128-32. PMID: 12423716, PII: S0002914902027819, ISSN: 0002-9149.

Kannankeril PJ, Goldberger JJ. Parasympathetic effects on cardiac electrophysiology during exercise and recovery. Am. J. Physiol. Heart Circ. Physiol. 2002 Jun; 282(6): H2091-8. PMID: 12003816, DOI: 10.1152/ajpheart.00825.2001, ISSN: 0363-6135.

Kannankeril PJ, Wax DF, Pahl E. Elevations of troponin I after interventional cardiac catheterization. Cardiol Young. 2001 Jul; 11(4): 375-8. PMID: 11558945, ISSN: 1047-9511.

Kannankeril PJ, Wax DF, Deal BJ, Johnsrude CL, Duffy CE. Simultaneous transcatheter closure of an atrial septal defect with an amplatzer septal occluder and radiofrequency ablation of an accessory connection. Catheter Cardiovasc Interv. 2000 Sep; 51(1): 55-7. PMID: 10973019, PII: 10.1002/1522-726X(200009)51:1<55::AID-CCD12>3.0.CO;2-Z, ISSN: 1522-1946.