Claudio A. Mosse, M.D., Ph.D.

Professor

c.mosse@vanderbilt.edu
Faculty Appointments
Professor of Pathology, Microbiology and Immunology
Education
M.D., Medicine, University of Virginia, Charlottesville, VirginiaPh.D., Microbiology and Immunology, University of Virginia, Charlottesville, VirginiaB.A., Chemistry and Biology, Cornell University, Ithaca, New York
Office Address
C2104B MCN Building
1161 21st Ave S
Nasvhille, TN 37232-5310
Research Description
My research is focused on using laboratory methods to define the best methods for disease detection, prognostication, and sub-classification.
Clinical Description
I am the Chief of Pathology and Lab Medicine at VA Tennessee Valley Healthcare System and in that capacity, I am the medical director of all of the clinical labs there. I also sign out hematopathology cases.
Research Keywords
Laboratory Medicine; Hematopathology; Hematology
Clinical Research Keywords
Hematopathology
Publications
Wang D, Lin M, Utz B, Bosompem A, Guo Y, Daneshbod Y, Alford CE, Nettles SA, Scher J, Gagne EY, O'Neill M, Barrow L, Wojciechowska N, Keegan J, Mosse CA, Lederer JA, Kim AS. MiR-378-3p Knockdown Recapitulates Many of the Features of Myelodysplastic Syndromes. Am J Pathol [print-electronic]. 2021 Nov; 191(11): 2009-22. PMID: 34364880, PMCID: PMC8579243, PII: S0002-9440(21)00343-6, DOI: 10.1016/j.ajpath.2021.07.006, ISSN: 1525-2191.

Wang D, Lin M, Utz B, Bosompem A, Guo Y, Daneshbod Y, Alford CE, Nettles SA, Scher J, Gagne EY, O'Neill M, Barrow L, Wojciechowska N, Keegan J, Mosse CA, Lederer JA, Kim AS. MiR-378-3p Knockdown Recapitulates Many of the Features of Myelodysplastic Syndromes. Am J Pathol [print-electronic]. 2021 Nov; 191(11): 2009-22. PMID: 34364880, PMCID: PMC8579243, PII: S0002-9440(21)00343-6, DOI: 10.1016/j.ajpath.2021.07.006, ISSN: 1525-2191.

Patel DA, Gopalakrishnan R, Engelhardt BG, McArthur E, Sengsayadeth S, Culos KA, Byrne M, Goodman S, Savani BN, Chinratanalab W, Jagasia M, Mosse CA, Cornell RF, Kassim AA. Minimal residual disease negativity and lenalidomide maintenance therapy are associated with superior survival outcomes in multiple myeloma. Bone Marrow Transplant [print-electronic]. 2020 Jun; 55(6): 1137-46. PMID: 31992845, PII: 10.1038/s41409-020-0791-y, DOI: 10.1038/s41409-020-0791-y, ISSN: 1476-5365.

Mast KJ, Taub JW, Alonzo TA, Gamis AS, Mosse CA, Mathew P, Berman JN, Wang YC, Jones HM, Campana D, Coustan-Smith E, Raimondi SC, Hirsch B, Hitzler JK, Head DR. Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431. Arch Pathol Lab Med [print-electronic]. 2020 Apr; 144(4): 466-72. PMID: 31429606, PMCID: PMC7031019, DOI: 10.5858/arpa.2018-0526-OA, ISSN: 1543-2165.

Mast KJ, Taub JW, Alonzo TA, Gamis AS, Mosse CA, Mathew P, Berman JN, Wang YC, Jones HM, Campana D, Coustan-Smith E, Raimondi SC, Hirsch B, Hitzler JK, Head DR. Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431. Arch Pathol Lab Med [print-electronic]. 2020 Apr; 144(4): 466-72. PMID: 31429606, PMCID: PMC7031019, DOI: 10.5858/arpa.2018-0526-OA, ISSN: 1543-2165.

Wierda WG, Byrd JC, Abramson JS, Bilgrami SF, Bociek G, Brander D, Brown J, Chanan-Khan AA, Chavez JC, Coutre SE, Davis RS, Fletcher CD, Hill B, Kahl BS, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Lim MS, Ma S, Malek S, Mato A, Mosse C, Shadman M, Siddiqi T, Stephens D, Sundaram S, Wagner N, Dwyer M, Sundar H. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 4.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020 Feb; 18(2): 185-217. PMID: 32023533, PII: jnccnGLS1802, DOI: 10.6004/jnccn.2020.0006.

Shah KP, Carroll CM, Mosse C, Yenamandra A, Borinstein SC. Sustained remission in a patient with PDGFR-beta-rearranged T-lymphoblastic lymphoma and complete remission with dasatinib. Pediatr Blood Cancer [print-electronic]. 2020 Jan; 67(1): e28026. PMID: 31571404, DOI: 10.1002/pbc.28026, ISSN: 1545-5017.

Clark CA, Mosse CA, Chen H, Byrne M, Chinratanalab W, Engelhardt BG, Goodman SA, Harrell SL, Kassim AA, Savani BN, Sengsayadeth S, Jagasia M, Cornell RF. Prospective trial of minimal residual disease assessment by multiparametric flow cytometry for multiple myeloma in the era of bortezomib-based chemotherapy [letter]. Bone Marrow Transplant [print-electronic]. 2018 Dec; 53(12): 1589-92. PMID: 29915217, PII: 10.1038/s41409-018-0241-2, DOI: 10.1038/s41409-018-0241-2, ISSN: 1476-5365.

Clark CA, Mosse CA, Chen H, Byrne M, Chinratanalab W, Engelhardt BG, Goodman SA, Harrell SL, Kassim AA, Savani BN, Sengsayadeth S, Jagasia M, Cornell RF. Prospective trial of minimal residual disease assessment by multiparametric flow cytometry for multiple myeloma in the era of bortezomib-based chemotherapy [letter]. Bone Marrow Transplant [print-electronic]. 2018 Dec; 53(12): 1589-92. PMID: 29915217, PII: 10.1038/s41409-018-0241-2, DOI: 10.1038/s41409-018-0241-2, ISSN: 1476-5365.

Wheeler FC, Kim AS, Mosse CA, Shaver AC, Yenamandra A, Seegmiller AC. Limited Utility of Fluorescence In Situ Hybridization for Recurrent Abnormalities in Acute Myeloid Leukemia at Diagnosis and Follow-up. Am J Clin Pathol. 2018 Mar 3/29/2018; 149(5): 418-24. PMID: 29538617, PMCID: PMC5888921, PII: 4925842, DOI: 10.1093/ajcp/aqy002, ISSN: 1943-7722.

Wheeler FC, Kim AS, Mosse CA, Shaver AC, Yenamandra A, Seegmiller AC. Limited Utility of Fluorescence In Situ Hybridization for Recurrent Abnormalities in Acute Myeloid Leukemia at Diagnosis and Follow-up. Am J Clin Pathol. 2018 Mar 3/29/2018; 149(5): 418-24. PMID: 29538617, PMCID: PMC5888921, PII: 4925842, DOI: 10.1093/ajcp/aqy002, ISSN: 1943-7722.

Strickland SA, Shaver AC, Byrne M, Daber RD, Ferrell PB, Head DR, Mohan SR, Mosse CA, Moyo TK, Stricker TP, Vnencak-Jones C, Savona MR, Seegmiller AC. Genotypic and clinical heterogeneity within NCCN favorable-risk acute myeloid leukemia. Leuk Res [print-electronic]. 2018 Feb; 65: 67-73. PMID: 29310020, PMCID: PMC5856485, PII: S0145-2126(17)30617-3, DOI: 10.1016/j.leukres.2017.12.012, ISSN: 1873-5835.

Strickland SA, Shaver AC, Byrne M, Daber RD, Ferrell PB, Head DR, Mohan SR, Mosse CA, Moyo TK, Stricker TP, Vnencak-Jones C, Savona MR, Seegmiller AC. Genotypic and clinical heterogeneity within NCCN favorable-risk acute myeloid leukemia. Leuk Res [print-electronic]. 2018 Feb; 65: 67-73. PMID: 29310020, PMCID: PMC5856485, PII: S0145-2126(17)30617-3, DOI: 10.1016/j.leukres.2017.12.012, ISSN: 1873-5835.

Seegmiller AC, Kim AS, Mosse CA, Shaver AC, Thompson MA, Li S, Head DR, Zutter MM. Data-Driven Iterative Refinement of Bone Marrow Testing Protocols Leads to Progressive Improvement in Cytogenetic and Molecular Test Utilization. Am J Clin Pathol. 2016 Nov 11/1/2016; 146(5): 585-93. PMID: 27769956, PII: aqw180, DOI: 10.1093/ajcp/aqw180, ISSN: 1943-7722.

Sherrod AM, Hari P, Mosse CA, Walker RC, Cornell RF. Minimal residual disease testing after stem cell transplantation for multiple myeloma. Bone Marrow Transplant [print-electronic]. 2016 Jan; 51(1): 2-12. PMID: 26191950, PII: bmt2015164, DOI: 10.1038/bmt.2015.164, ISSN: 1476-5365.

Sherrod AM, Hari P, Mosse CA, Walker RC, Cornell RF. Minimal residual disease testing after stem cell transplantation for multiple myeloma. Bone Marrow Transplant [print-electronic]. 2016 Jan; 51(1): 2-12. PMID: 26191950, PII: bmt2015164, DOI: 10.1038/bmt.2015.164, ISSN: 1476-5365.

Shaver AC, Greig BW, Mosse CA, Seegmiller AC. B-ALL minimal residual disease flow cytometry: an application of a novel method for optimization of a single-tube model. Am J Clin Pathol. 2015 May; 143(5): 716-24. PMID: 25873506, PII: 143/5/716, DOI: 10.1309/AJCPOOJRAVUN75GD, ISSN: 1943-7722.

Shaver AC, Greig BW, Mosse CA, Seegmiller AC. B-ALL minimal residual disease flow cytometry: an application of a novel method for optimization of a single-tube model. Am J Clin Pathol. 2015 May; 143(5): 716-24. PMID: 25873506, PII: 143/5/716, DOI: 10.1309/AJCPOOJRAVUN75GD, ISSN: 1943-7722.

Salazar KL, Mosse C. Normal karyotype in a case of acute myeloid leukemia with monocytic differentiation and hemophagocytosis by leukemic blasts. Lab Med. 2015; 46(1): 64-8. PMID: 25617396, PII: 46/1/64, DOI: 10.1309/LMUDI1L6PU0MYHSL, ISSN: 1943-7730.

Kauffmann RM, Grayson BL, Mosse CA, Geiger TM. Perineal lymphoma: a diagnostic dilemma. Am Surg. 2014 Nov; 80(11): E302-3. PMID: 25347485, ISSN: 1555-9823.

Kauffmann RM, Grayson BL, Mosse CA, Geiger TM. Perineal lymphoma: a diagnostic dilemma. Am Surg. 2014 Nov; 80(11): E302-3. PMID: 25347485, ISSN: 1555-9823.

Seegmiller AC, Kim AS, Mosse CA, Levy MA, Thompson MA, Kressin MK, Jagasia MH, Strickland SA, Reddy NM, Marx ER, Sinkfield KJ, Pollard HN, Plummer WD, Dupont WD, Shultz EK, Dittus RS, Stead WW, Santoro SA, Zutter MM. Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Am J Clin Pathol. 2013 Nov; 140(5): 643-50. PMID: 24124142, PMCID: PMC4159763, PII: 140/5/643, DOI: 10.1309/AJCP8CKE9NEINQFL, ISSN: 1943-7722.

Seegmiller AC, Kim AS, Mosse CA, Levy MA, Thompson MA, Kressin MK, Jagasia MH, Strickland SA, Reddy NM, Marx ER, Sinkfield KJ, Pollard HN, Plummer WD, Dupont WD, Shultz EK, Dittus RS, Stead WW, Santoro SA, Zutter MM. Optimizing personalized bone marrow testing using an evidence-based, interdisciplinary team approach. Am J Clin Pathol. 2013 Nov; 140(5): 643-50. PMID: 24124142, PMCID: PMC4159763, PII: 140/5/643, DOI: 10.1309/AJCP8CKE9NEINQFL, ISSN: 1943-7722.

Rosado FG, Tang YW, Hasserjian RP, McClain CM, Wang B, Mosse CA. Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8. Hum Pathol [print-electronic]. 2013 Feb; 44(2): 255-9. PMID: 22939574, PII: S0046-8177(12)00192-X, DOI: 10.1016/j.humpath.2012.05.016, ISSN: 1532-8392.

Rosado FG, Tang YW, Hasserjian RP, McClain CM, Wang B, Mosse CA. Kikuchi-Fujimoto lymphadenitis: role of parvovirus B-19, Epstein-Barr virus, human herpesvirus 6, and human herpesvirus 8. Hum Pathol [print-electronic]. 2013 Feb; 44(2): 255-9. PMID: 22939574, PII: S0046-8177(12)00192-X, DOI: 10.1016/j.humpath.2012.05.016, ISSN: 1532-8392.

Lozanski G, Pennell M, Shana'ah A, Zhao W, Gewirtz A, Racke F, Hsi E, Simpson S, Mosse C, Alam S, Swierczynski S, Hasserjian RP, Gurcan MN. Inter-reader variability in follicular lymphoma grading: Conventional and digital reading. J Pathol Inform. 2013; 4: 30. PMID: 24392244, PMCID: PMC3869955, PII: JPI-4-30, DOI: 10.4103/2153-3539.120747, ISSN: 2229-5089.

Hart AJ, Jagasia MH, Kim AS, Mosse CA, Savani BN, Kassim A. Minimal residual disease in myeloma: are we there yet?. Biol Blood Marrow Transplant [print-electronic]. 2012 Dec; 18(12): 1790-9. PMID: 22626785, PII: S1083-8791(12)00211-X, DOI: 10.1016/j.bbmt.2012.05.009, ISSN: 1523-6536.

Hart AJ, Jagasia MH, Kim AS, Mosse CA, Savani BN, Kassim A. Minimal residual disease in myeloma: are we there yet?. Biol Blood Marrow Transplant [print-electronic]. 2012 Dec; 18(12): 1790-9. PMID: 22626785, PII: S1083-8791(12)00211-X, DOI: 10.1016/j.bbmt.2012.05.009, ISSN: 1523-6536.

Thu YM, Su Y, Yang J, Splittgerber R, Na S, Boyd A, Mosse C, Simons C, Richmond A. NF-¿B inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the ß-catenin pathway. Oncogene [print-electronic]. 2012 May 5/17/2012; 31(20): 2580-92. PMID: 21963849, PMCID: PMC3253179, PII: onc2011427, DOI: 10.1038/onc.2011.427, ISSN: 1476-5594.

Eckrich MJ, Frangoul H, Knight J, Mosse C, Domm J. A case of pediatric PTLD following autologous stem cell transplantation and review of the literature. Pediatr Transplant [print-electronic]. 2012 Feb; 16(1): E15-8. PMID: 20819185, PII: PTR1382, DOI: 10.1111/j.1399-3046.2010.01382.x, ISSN: 1399-3046.

Rosado FG, Stratton CW, Mosse CA. Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis. Arch Pathol Lab Med. 2011 Nov; 135(11): 1490-3. PMID: 22032579, DOI: 10.5858/arpa.2010-0581-OA, ISSN: 1543-2165.

Rosado FG, Stratton CW, Mosse CA. Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis. Arch Pathol Lab Med. 2011 Nov; 135(11): 1490-3. PMID: 22032579, DOI: 10.5858/arpa.2010-0581-OA, ISSN: 1543-2165.

McClintock-Treep SA, Briggs RC, Shults KE, Flye-Blakemore LA, Mosse CA, Jagasia MH, Shinar AA, Dupont WD, Stelzer GT, Head DR. Quantitative assessment of myeloid nuclear differentiation antigen distinguishes myelodysplastic syndrome from normal bone marrow. Am J Clin Pathol. 2011 Mar; 135(3): 380-5. PMID: 21350091, PII: 135/3/380, DOI: 10.1309/AJCP00SHTQCVUYRI, ISSN: 1943-7722.

McClintock-Treep SA, Briggs RC, Shults KE, Flye-Blakemore LA, Mosse CA, Jagasia MH, Shinar AA, Dupont WD, Stelzer GT, Head DR. Quantitative assessment of myeloid nuclear differentiation antigen distinguishes myelodysplastic syndrome from normal bone marrow. Am J Clin Pathol. 2011 Mar; 135(3): 380-5. PMID: 21350091, PII: 135/3/380, DOI: 10.1309/AJCP00SHTQCVUYRI, ISSN: 1943-7722.

Head DR, Jacobberger JW, Mosse C, Jagasia M, Dupont W, Goodman S, Flye L, Shinar A, McClintock-Treep S, Stelzer G, Briggs R, Shults K. Innovative analyses support a role for DNA damage and an aberrant cell cycle in myelodysplastic syndrome pathogenesis. Bone Marrow Res [print-electronic]. 2011; 2011: 950934. PMID: 22046573, PMCID: PMC3200066, DOI: 10.1155/2011/950934, ISSN: 2090-3006.

Austin ED, Rock MT, Mosse CA, Vnencak-Jones CL, Yoder SM, Robbins IM, Loyd JE, Meyrick BO. T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension. Respir Med [print-electronic]. 2010 Mar; 104(3): 454-62. PMID: 19880300, PMCID: PMC2826574, PII: S0954-6111(09)00325-4, DOI: 10.1016/j.rmed.2009.10.004, ISSN: 1532-3064.

Austin ED, Rock MT, Mosse CA, Vnencak-Jones CL, Yoder SM, Robbins IM, Loyd JE, Meyrick BO. T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension. Respir Med [print-electronic]. 2010 Mar; 104(3): 454-62. PMID: 19880300, PMCID: PMC2826574, PII: S0954-6111(09)00325-4, DOI: 10.1016/j.rmed.2009.10.004, ISSN: 1532-3064.

Greer JP, Mosse CA. Natural killer-cell neoplasms. Curr Hematol Malig Rep. 2009 Oct; 4(4): 245-52. PMID: 20425414, DOI: 10.1007/s11899-009-0032-3, ISSN: 1558-822X.

Greer JP, Mosse CA. Natural killer-cell neoplasms. Curr Hematol Malig Rep. 2009 Oct; 4(4): 245-52. PMID: 20425414, DOI: 10.1007/s11899-009-0032-3, ISSN: 1558-822X.

Mosse CA, Stumph JR, Best DH, Vnencak-Jones CL. A B-cell lymphoma diagnosed in "floater" tissue: implications of the diagnosis and resolution of a laboratory error. Am J Med Sci. 2009 Sep; 338(3): 248-51. PMID: 19745614, PII: S0002-9629(15)31887-5, DOI: 10.1097/MAJ.0b013e3181a88dc0, ISSN: 1538-2990.

Mosse CA, Stumph JR, Best DH, Vnencak-Jones CL. A B-cell lymphoma diagnosed in "floater" tissue: implications of the diagnosis and resolution of a laboratory error. Am J Med Sci. 2009 Sep; 338(3): 248-51. PMID: 19745614, PII: S0002-9629(15)31887-5, DOI: 10.1097/MAJ.0b013e3181a88dc0, ISSN: 1538-2990.

Huang Y, Chen X, Dikov MM, Novitskiy SV, Mosse CA, Yang L, Carbone DP. Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood [print-electronic]. 2007 Jul 7/15/2007; 110(2): 624-31. PMID: 17376891, PMCID: PMC1924481, PII: S0006-4971(20)41273-X, DOI: 10.1182/blood-2007-01-065714, ISSN: 0006-4971.

Huang Y, Chen X, Dikov MM, Novitskiy SV, Mosse CA, Yang L, Carbone DP. Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood [print-electronic]. 2007 Jul 7/15/2007; 110(2): 624-31. PMID: 17376891, PMCID: PMC1924481, PII: S0006-4971(20)41273-X, DOI: 10.1182/blood-2007-01-065714, ISSN: 0006-4971.

Santoro SA, Mosse CA, Young PP. The MD/PhD pathway to a career in laboratory medicine. Clin Lab Med. 2007 Jun; 27(2): 425-34; abstract ix. PMID: 17556094, PII: S0272-2712(07)00028-5, DOI: 10.1016/j.cll.2007.03.012, ISSN: 0272-2712.

Santoro SA, Mosse CA, Young PP. The MD/PhD pathway to a career in laboratory medicine. Clin Lab Med. 2007 Jun; 27(2): 425-34; abstract ix. PMID: 17556094, PII: S0272-2712(07)00028-5, DOI: 10.1016/j.cll.2007.03.012, ISSN: 0272-2712.

Whartenby KA, Calabresi PA, McCadden E, Nguyen B, Kardian D, Wang T, Mosse C, Pardoll DM, Small D. Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2005 Nov 11/15/2005; 102(46): 16741-6. PMID: 16272221, PMCID: PMC1283812, PII: 0506088102, DOI: 10.1073/pnas.0506088102, ISSN: 0027-8424.

Mosse CA, Magi-Galluzzi C, Tsuzuki T, Epstein JI. The prognostic significance of tertiary Gleason pattern 5 in radical prostatectomy specimens. Am. J. Surg. Pathol. 2004 Mar; 28(3): 394-8. PMID: 15104304, ISSN: 0147-5185.

Mosse CA, Hsu W, Engelhard VH. Tyrosinase degradation via two pathways during reverse translocation to the cytosol. Biochem. Biophys. Res. Commun. 2001 Jul 7/13/2001; 285(2): 313-9. PMID: 11444844, PII: S0006-291X(01)95153-8, DOI: 10.1006/bbrc.2001.5153, ISSN: 0006-291X.

Mosse CA, Meadows L, Luckey CJ, Kittlesen DJ, Huczko EL, Slingluff CL, Shabanowitz J, Hunt DF, Engelhard VH. The class I antigen-processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosol. J. Exp. Med. 1998 Jan 1/5/1998; 187(1): 37-48. PMID: 9419209, PMCID: PMC2199193, ISSN: 0022-1007.

Shirazi A, Iizuka K, Fadden P, Mosse C, Somlyo AP, Somlyo AV, Haystead TA. Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle. J. Biol. Chem. 1994 Dec 12/16/1994; 269(50): 31598-606. PMID: 7989330, ISSN: 0021-9258.

Haystead CM, Gregory P, Shirazi A, Fadden P, Mosse C, Dent P, Haystead TA. Insulin activates a novel adipocyte mitogen-activated protein kinase kinase kinase that shows rapid phasic kinetics and is distinct from c-Raf. J. Biol. Chem. 1994 Apr 4/29/1994; 269(17): 12804-8. PMID: 8175693, ISSN: 0021-9258.