Edward D. Siew, M.D.

Associate Professor

Faculty Appointments
Associate Professor of Medicine
M.S.C.I., Clinical Investigation, Vanderbilt University, Nashville, TennesseeM.D., Medicine, University of Chicago, Chicago, IllinoisB.A., Biology, Johns Hopkins University, Baltimore, Maryland
Office Address
1161 21st Ave South
MCN S-3223
Nashville, TN 37232-2372
Research Description
Our main research interest surrounds the translational and epidemiologic study of Acute Kidney Injury (AKI). Specific areas of focus include the use of biomarkers for the early detection, phenotyping, and prognosis of this disease; the impact of AKI on long-term kidney function and overall health; and the use of biomedical informatics to help improve delivery of care to patients hospitalized with AKI.
Research Keywords
Clinical Research Keywords
Acute Kidney Injury, Biomarkers, Proteomics, Early Detection and Prognosis, Critical Illness, intensive care unit, sepsis, renal replacement therapy
Davis SE, Lasko TA, Chen G, Siew ED, Matheny ME. Calibration drift in regression and machine learning models for acute kidney injury. J Am Med Inform Assoc. 2017 Nov 11/1/2017; 24(6): 1052-61. PMID: 28379439, PII: 3096776, DOI: 10.1093/jamia/ocx030, ISSN: 1527-974X.

Salat H, Javier A, Siew ED, Figueroa R, Lipworth L, Kabagambe E, Bian A, Stewart TG, El-Sourady MH, Karlekar M, Cardona CY, Ikizler TA, Abdel-Kader K. Nephrology Provider Prognostic Perceptions and Care Delivered to Older Adults with Advanced Kidney Disease. Clin J Am Soc Nephrol [print-electronic]. 2017 Sep 9/18/2017; PMID: 28923833, PII: CJN.03830417, DOI: 10.2215/CJN.03830417, ISSN: 1555-905X.

Parr SK, Matheny ME, Abdel-Kader K, Greevy RA, Bian A, Fly J, Chen G, Speroff T, Hung AM, Ikizler TA, Siew ED. Acute kidney injury is a risk factor for subsequent proteinuria. Kidney Int [print-electronic]. 2017 Sep 9/16/2017; PMID: 28927644, PII: S0085-2538(17)30537-9, DOI: 10.1016/j.kint.2017.07.007, ISSN: 1523-1755.

Hsu RK, Siew ED. The growth of AKI: half empty or half full, it's the size of the glass that matters. Kidney Int. 2017 Sep; 92(3): 550-3. PMID: 28807263, PII: S0085-2538(17)30400-3, DOI: 10.1016/j.kint.2017.04.047, ISSN: 1523-1755.

Acedillo RR, Wald R, McArthur E, Nash DM, Silver SA, James MT, Schull MJ, Siew ED, Matheny ME, House AA, Garg AX. Characteristics and Outcomes of Patients Discharged Home from an Emergency Department with AKI. Clin J Am Soc Nephrol [print-electronic]. 2017 Jul 7/20/2017; PMID: 28729384, PMCID: PMC5544515, PII: CJN.10431016, DOI: 10.2215/CJN.10431016, ISSN: 1555-905X.

Javier AD, Figueroa R, Siew ED, Salat H, Morse J, Stewart TG, Malhotra R, Jhamb M, Schell JO, Cardona CY, Maxwell CA, Ikizler TA, Abdel-Kader K. Reliability and Utility of the Surprise Question in CKD Stages 4 to 5. Am. J. Kidney Dis [print-electronic]. 2017 Jul; 70(1): 93-101. PMID: 28215946, PII: S0272-6386(17)30006-9, DOI: 10.1053/j.ajkd.2016.11.025, ISSN: 1523-6838.

Silver SA, Siew ED. Follow-up Care in Acute Kidney Injury: Lost in Transition. Adv Chronic Kidney Dis. 2017 Jul; 24(4): 246-52. PMID: 28778365, PII: S1548-5595(17)30085-X, DOI: 10.1053/j.ackd.2017.05.008, ISSN: 1548-5609.

Siew ED, Fissell WH, Tripp CM, Blume JD, Wilson MD, Clark AJ, Vincz AJ, Ely EW, Pandharipande PP, Girard TD. Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness. Am. J. Respir. Crit. Care Med. 2017 Jun 6/15/2017; 195(12): 1597-607. PMID: 27854517, PMCID: PMC5476907, DOI: 10.1164/rccm.201603-0476OC, ISSN: 1535-4970.

Deger SM, Wang P, Fissell R, Ellis CD, Booker C, Sha F, Morse JL, Stewart TG, Gore JC, Siew ED, Titze J, Ikizler TA. Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients. J Cachexia Sarcopenia Muscle [print-electronic]. 2017 Jun; 8(3): 500-7. PMID: 28150400, PMCID: PMC5476848, DOI: 10.1002/jcsm.12179, ISSN: 2190-6009.

Semler MW, Wanderer JP, Ehrenfeld JM, Stollings JL, Self WH, Siew ED, Wang L, Byrne DW, Shaw AD, Bernard GR, Rice TW, , . Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized Trial. Am. J. Respir. Crit. Care Med. 2017 May 5/15/2017; 195(10): 1362-72. PMID: 27749094, PMCID: PMC5443900, DOI: 10.1164/rccm.201607-1345OC, ISSN: 1535-4970.

Janak JC, Stewart IJ, Sosnov JA, Howard JT, Siew ED, Chan MM, Wickersham N, Ikizler TA, Chung KK. Urinary Biomarkers are Associated with Severity and Mechanism of Injury. Shock. 2017 May; 47(5): 593-8. PMID: 27798535, PMCID: PMC5392149, DOI: 10.1097/SHK.0000000000000784, ISSN: 1540-0514.

Chawla LS, Bellomo R, Bihorac A, Goldstein SL, Siew ED, Bagshaw SM, Bittleman D, Cruz D, Endre Z, Fitzgerald RL, Forni L, Kane-Gill SL, Hoste E, Koyner J, Liu KD, Macedo E, Mehta R, Murray P, Nadim M, Ostermann M, Palevsky PM, Pannu N, Rosner M, Wald R, Zarbock A, Ronco C, Kellum JA, . Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. Nat Rev Nephrol [print-electronic]. 2017 Apr; 13(4): 241-57. PMID: 28239173, PII: nrneph.2017.2, DOI: 10.1038/nrneph.2017.2.

Semler MW, Self WH, Wang L, Byrne DW, Wanderer JP, Ehrenfeld JM, Stollings JL, Kumar AB, Hernandez A, Guillamondegui OD, May AK, Siew ED, Shaw AD, Bernard GR, Rice TW, , . Balanced crystalloids versus saline in the intensive care unit: study protocol for a cluster-randomized, multiple-crossover trial. Trials. 2017 Mar 3/16/2017; 18(1): 129. PMID: 28302179, PMCID: PMC5356286, PII: 10.1186/s13063-017-1871-1, DOI: 10.1186/s13063-017-1871-1, ISSN: 1745-6215.

Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR, . A Genome-Wide Association Study to Identify Single-Nucleotide Polymorphisms for Acute Kidney Injury. Am. J. Respir. Crit. Care Med. 2017 Feb 2/15/2017; 195(4): 482-90. PMID: 27576016, PMCID: PMC5378420, DOI: 10.1164/rccm.201603-0518OC, ISSN: 1535-4970.

Smith LE, Smith DK, Blume JD, Siew ED, Billings FT. Latent variable modeling improves AKI risk factor identification and AKI prediction compared to traditional methods. BMC Nephrol. 2017 Feb 2/8/2017; 18(1): 55. PMID: 28178929, PMCID: PMC5299779, PII: 10.1186/s12882-017-0465-1, DOI: 10.1186/s12882-017-0465-1, ISSN: 1471-2369.

Ku E, Gassman J, Appel LJ, Smogorzewski M, Sarnak MJ, Glidden DV, Bakris G, GutiƩrrez OM, Hebert LA, Ix JH, Lea J, Lipkowitz MS, Norris K, Ploth D, Pogue VA, Rostand SG, Siew ED, Sika M, Tisher CC, Toto R, Wright JT, Wyatt C, Hsu CY. BP Control and Long-Term Risk of ESRD and Mortality. J. Am. Soc. Nephrol [print-electronic]. 2017 Feb; 28(2): 671-7. PMID: 27516235, PMCID: PMC5280023, PII: ASN.2016030326, DOI: 10.1681/ASN.2016030326, ISSN: 1533-3450.

Malhotra R, Siew ED. Biomarkers for the Early Detection and Prognosis of Acute Kidney Injury. Clin J Am Soc Nephrol [print-electronic]. 2017 Jan 1/6/2017; 12(1): 149-73. PMID: 27827308, PMCID: PMC5220647, PII: CJN.01300216, DOI: 10.2215/CJN.01300216, ISSN: 1555-905X.

Lipworth L, Abdel-Kader K, Morse J, Stewart TG, Kabagambe EK, Parr SK, Birdwell KA, Matheny ME, Hung AM, Blot WJ, Ikizler TA, Siew ED. High prevalence of non-steroidal anti-inflammatory drug use among acute kidney injury survivors in the southern community cohort study. BMC Nephrol. 2016 Nov 11/24/2016; 17(1): 189. PMID: 27881100, PMCID: PMC5122006, PII: 10.1186/s12882-016-0411-7, DOI: 10.1186/s12882-016-0411-7, ISSN: 1471-2369.

Held EP, Iglesia EA, Johnson AS, Fang JY, Wilson MH, Abel TW, Lake W, Siew ED. Neurosarcoidosis Presenting as Aseptic Meningitis in an Immunosuppressed Renal Transplant Recipient. Transplantation. 2016 Oct; 100(10): e96-e100. PMID: 26863472, DOI: 10.1097/TP.0000000000001074, ISSN: 1534-6080.

Semler MW, Rice TW, Shaw AD, Siew ED, Self WH, Kumar AB, Byrne DW, Ehrenfeld JM, Wanderer JP. Identification of Major Adverse Kidney Events Within the Electronic Health Record. J Med Syst [print-electronic]. 2016 Jul; 40(7): 167. PMID: 27234478, PII: 10.1007/s10916-016-0528-z, DOI: 10.1007/s10916-016-0528-z, ISSN: 1573-689X.

Parr SK, Siew ED. Delayed Consequences of Acute Kidney Injury. Adv Chronic Kidney Dis. 2016 May; 23(3): 186-94. PMID: 27113695, PMCID: PMC4849427, PII: S1548-5595(16)00015-X, DOI: 10.1053/j.ackd.2016.01.014, ISSN: 1548-5609.

Siew ED, Parr SK, Abdel-Kader K, Eden SK, Peterson JF, Bansal N, Hung AM, Fly J, Speroff T, Ikizler TA, Matheny ME. Predictors of Recurrent AKI. J. Am. Soc. Nephrol [print-electronic]. 2016 Apr; 27(4): 1190-200. PMID: 26264853, PMCID: PMC4814177, PII: ASN.2014121218, DOI: 10.1681/ASN.2014121218, ISSN: 1533-3450.

Brown JR, Rezaee ME, Nichols EL, Marshall EJ, Siew ED, Matheny ME. Incidence and In-Hospital Mortality of Acute Kidney Injury (AKI) and Dialysis-Requiring AKI (AKI-D) After Cardiac Catheterization in the National Inpatient Sample. J Am Heart Assoc. 2016 Mar 3/15/2016; 5(3): e002739. PMID: 27068629, PMCID: PMC4943252, PII: JAHA.115.002739, DOI: 10.1161/JAHA.115.002739, ISSN: 2047-9980.

Liu KD, Siew ED, Reeves WB, Himmelfarb J, Go AS, Hsu CY, Bennett MR, Devarajan P, Ikizler TA, Kaufman JS, Kimmel PL, Chinchilli VM, Parikh CR, . Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study. PLoS ONE. 2016; 11(10): e0164832. PMID: 27788160, PMCID: PMC5082822, PII: PONE-D-16-05176, DOI: 10.1371/journal.pone.0164832, ISSN: 1932-6203.

Siew ED, Basu RK, Wunsch H, Shaw AD, Goldstein SL, Ronco C, Kellum JA, Bagshaw SM, . Optimizing administrative datasets to examine acute kidney injury in the era of big data: workgroup statement from the 15(th) ADQI Consensus Conference. Can J Kidney Health Dis. 2016; 3: 12. PMID: 26925248, PMCID: PMC4768415, PII: 98, DOI: 10.1186/s40697-016-0098-5, ISSN: 2054-3581.

Brown JR, MacKenzie TA, Maddox TM, Fly J, Tsai TT, Plomondon ME, Nielson CD, Siew ED, Resnic FS, Baker CR, Rumsfeld JS, Matheny ME. Acute Kidney Injury Risk Prediction in Patients Undergoing Coronary Angiography in a National Veterans Health Administration Cohort With External Validation. J Am Heart Assoc. 2015 Dec 12/11/2015; 4(12): PMID: 26656858, PMCID: PMC4845295, PII: JAHA.115.002136, DOI: 10.1161/JAHA.115.002136, ISSN: 2047-9980.

Parr SK, Bian A, K Shintani A, Ware LB, Alp Ikizler T, Siew ED. The Authors Reply [letter]. Kidney Int. 2015 Sep; 88(3): 639-40. PMID: 26323077, PMCID: PMC4587760, PII: S2157-1716(15)32229-2, DOI: 10.1038/ki.2015.222, ISSN: 1523-1755.

Cronin RM, VanHouten JP, Siew ED, Eden SK, Fihn SD, Nielson CD, Peterson JF, Baker CR, Ikizler TA, Speroff T, Matheny ME. National Veterans Health Administration inpatient risk stratification models for hospital-acquired acute kidney injury. J Am Med Inform Assoc [print-electronic]. 2015 Sep; 22(5): 1054-71. PMID: 26104740, PMCID: PMC5009929, PII: ocv051, DOI: 10.1093/jamia/ocv051, ISSN: 1527-974X.

Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB. Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Crit. Care Med. 2015 Sep; 43(9): 1790-7. PMID: 26010690, PMCID: PMC4737582, DOI: 10.1097/CCM.0000000000001089, ISSN: 1530-0293.

Stewart IJ, Glass KR, Howard JT, Morrow BD, Sosnov JA, Siew ED, Wickersham N, Latack W, Kwan HK, Heegard KD, Diaz C, Henderson AT, Saenz KK, Ikizler TA, Chung KK. The potential utility of urinary biomarkers for risk prediction in combat casualties: a prospective observational cohort study. Crit Care. 2015 Jun 6/16/2015; 19: 252. PMID: 26077788, PMCID: PMC4487799, PII: 10.1186/s13054-015-0965-y, DOI: 10.1186/s13054-015-0965-y, ISSN: 1466-609X.

Heegard KD, Stewart IJ, Cap AP, Sosnov JA, Kwan HK, Glass KR, Morrow BD, Latack W, Henderson AT, Saenz KK, Siew ED, Ikizler TA, Chung KK. Early acute kidney injury in military casualties. J Trauma Acute Care Surg. 2015 May; 78(5): 988-93. PMID: 25909420, PII: 01586154-201505000-00014, DOI: 10.1097/TA.0000000000000607, ISSN: 2163-0763.

Parr SK, Clark AJ, Bian A, Shintani AK, Wickersham NE, Ware LB, Ikizler TA, Siew ED. Urinary L-FABP predicts poor outcomes in critically ill patients with early acute kidney injury. Kidney Int [print-electronic]. 2015 Mar; 87(3): 640-8. PMID: 25229339, PMCID: PMC4344867, PII: S0085-2538(15)30159-9, DOI: 10.1038/ki.2014.301, ISSN: 1523-1755.

Hung AM, Booker C, Ellis CD, Siew ED, Graves AJ, Shintani A, Abumrad NN, Himmelfarb J, Ikizler TA. Omega-3 fatty acids inhibit the up-regulation of endothelial chemokines in maintenance hemodialysis patients. Nephrol. Dial. Transplant [print-electronic]. 2015 Feb; 30(2): 266-74. PMID: 25204316, PMCID: PMC4309191, PII: gfu283, DOI: 10.1093/ndt/gfu283, ISSN: 1460-2385.

Siew ED, Matheny ME. Choice of Reference Serum Creatinine in Defining Acute Kidney Injury. Nephron [print-electronic]. 2015; 131(2): 107-12. PMID: 26332325, PMCID: PMC4618709, PII: 000439144, DOI: 10.1159/000439144, ISSN: 2235-3186.

Siew ED, Davenport A. The growth of acute kidney injury: a rising tide or just closer attention to detail?. Kidney Int [print-electronic]. 2015 Jan; 87(1): 46-61. PMID: 25229340, PMCID: PMC4281297, PII: S0085-2538(15)30027-2, DOI: 10.1038/ki.2014.293, ISSN: 1523-1755.

Hung AM, Limkunakul C, Placido JS, Siew ED, Ellis CD, Shintani A, Ikizler TA. Administration of IL-1ra improves adiponectin levels in chronic hemodialysis patients. J. Nephrol [print-electronic]. 2014 Dec; 27(6): 681-8. PMID: 24609887, PII: 10.1007/s40620-014-0070-3, DOI: 10.1007/s40620-014-0070-3, ISSN: 1724-6059.

Parikh CR, Butrymowicz I, Yu A, Chinchilli VM, Park M, Hsu CY, Reeves WB, Devarajan P, Kimmel PL, Siew ED, Liu KD, . Urine stability studies for novel biomarkers of acute kidney injury. Am. J. Kidney Dis [print-electronic]. 2014 Apr; 63(4): 567-72. PMID: 24200462, PMCID: PMC3969397, PII: S0272-6386(13)01285-7, DOI: 10.1053/j.ajkd.2013.09.013, ISSN: 1523-6838.

Siew ED, Furth SL. Acute kidney injury: a not-so-silent disease. Kidney Int. 2014 Mar; 85(3): 494-5. PMID: 24583979, PMCID: PMC4000542, PII: S0085-2538(15)56230-3, DOI: 10.1038/ki.2013.389, ISSN: 1523-1755.

Matheny ME, Peterson JF, Eden SK, Hung AM, Speroff T, Abdel-Kader K, Parr SK, Ikizler TA, Siew ED. Laboratory test surveillance following acute kidney injury. PLoS ONE. 2014; 9(8): e103746. PMID: 25117447, PMCID: PMC4130516, PII: PONE-D-14-10168, DOI: 10.1371/journal.pone.0103746, ISSN: 1932-6203.

Siew ED, Ware LB, Bian A, Shintani A, Eden SK, Wickersham N, Cripps B, Ikizler TA. Distinct injury markers for the early detection and prognosis of incident acute kidney injury in critically ill adults with preserved kidney function. Kidney Int [print-electronic]. 2013 Oct; 84(4): 786-94. PMID: 23698227, PMCID: PMC3788840, PII: ki2013174, DOI: 10.1038/ki.2013.174, ISSN: 1523-1755.

Cox ZL, McCoy AB, Matheny ME, Bhave G, Peterson NB, Siew ED, Lewis J, Danciu I, Bian A, Shintani A, Ikizler TA, Neal EB, Peterson JF. Adverse drug events during AKI and its recovery. Clin J Am Soc Nephrol [print-electronic]. 2013 Jul; 8(7): 1070-8. PMID: 23539228, PMCID: PMC3700703, PII: CJN.11921112, DOI: 10.2215/CJN.11921112, ISSN: 1555-905X.

Deger SM, Sundell MB, Siew ED, Egbert P, Ellis CD, Sha F, Ikizler TA, Hung AM. Insulin resistance and protein metabolism in chronic hemodialysis patients. J Ren Nutr [print-electronic]. 2013 May; 23(3): e59-66. PMID: 23194840, PMCID: PMC3852904, PII: S1051-2276(12)00198-7, DOI: 10.1053/j.jrn.2012.08.013, ISSN: 1532-8503.

Hung AM, Sundell MB, Plotnikova NE, Bian A, Shintani A, Ellis CD, Siew ED, Ikizler TA. A pilot study of active vitamin D administration and insulin resistance in African American patients undergoing chronic hemodialysis. J Ren Nutr [print-electronic]. 2013 May; 23(3): 185-93. PMID: 22959781, PMCID: PMC3519966, PII: S1051-2276(12)00143-4, DOI: 10.1053/j.jrn.2012.06.005, ISSN: 1532-8503.

Siew ED, Peterson JF, Eden SK, Moons KG, Ikizler TA, Matheny ME. Use of multiple imputation method to improve estimation of missing baseline serum creatinine in acute kidney injury research. Clin J Am Soc Nephrol [print-electronic]. 2013 Jan; 8(1): 10-8. PMID: 23037980, PMCID: PMC3531649, PII: CJN.00200112, DOI: 10.2215/CJN.00200112, ISSN: 1555-905X.

Fatima H, Siew ED, Dwyer JP, Paueksakon P. Membranous glomerulopathy with superimposed pauci-immune necrotizing crescentic glomerulonephritis. Clin Kidney J. 2012 Dec; 5(6): 587-90. PMID: 26069808, PMCID: PMC4400567, PII: sfs145, DOI: 10.1093/ckj/sfs145, ISSN: 2048-8505.

Siew ED, Deger SM. Recent advances in acute kidney injury epidemiology. Curr. Opin. Nephrol. Hypertens. 2012 May; 21(3): 309-17. PMID: 22449946, PMCID: PMC3357067, DOI: 10.1097/MNH.0b013e3283521d95, ISSN: 1473-6543.

Siew ED, Ikizler TA, Matheny ME, Shi Y, Schildcrout JS, Danciu I, Dwyer JP, Srichai M, Hung AM, Smith JP, Peterson JF. Estimating baseline kidney function in hospitalized patients with impaired kidney function. Clin J Am Soc Nephrol [print-electronic]. 2012 May; 7(5): 712-9. PMID: 22422536, PMCID: PMC3338282, PII: CJN.10821011, DOI: 10.2215/CJN.10821011, ISSN: 1555-905X.

Siew ED, Peterson JF, Eden SK, Hung AM, Speroff T, Ikizler TA, Matheny ME. Outpatient nephrology referral rates after acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2012 Feb; 23(2): 305-12. PMID: 22158435, PMCID: PMC3269178, PII: ASN.2011030315, DOI: 10.1681/ASN.2011030315, ISSN: 1533-3450.

McCoy AB, Cox ZL, Neal EB, Waitman LR, Peterson NB, Bhave G, Siew ED, Danciu I, Lewis JB, Peterson JF. Real-time pharmacy surveillance and clinical decision support to reduce adverse drug events in acute kidney injury: a randomized, controlled trial. Appl Clin Inform [print-electronic]. 2012 Jan 1/1/2012; 3(2): 221-38. PMID: 22719796, PMCID: PMC3377180, DOI: 10.4338/ACI-2012-03-RA-0009, ISSN: 1869-0327.

Siew ED. Blind men and elephants and the biological markers of AKI [editorial]. J. Am. Soc. Nephrol [print-electronic]. 2011 Sep; 22(9): 1578-80. PMID: 21836142, PII: ASN.2011070736, DOI: 10.1681/ASN.2011070736, ISSN: 1533-3450.

O'Neal HR, Koyama T, Koehler EA, Siew E, Curtis BR, Fremont RD, May AK, Bernard GR, Ware LB. Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit. Care Med. 2011 Jun; 39(6): 1343-50. PMID: 21336116, PMCID: PMC3102130, DOI: 10.1097/CCM.0b013e3182120992, ISSN: 1530-0293.

Siew ED, Ware LB, Ikizler TA. Biological markers of acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2011 May; 22(5): 810-20. PMID: 21493774, PII: ASN.2010080796, DOI: 10.1681/ASN.2010080796, ISSN: 1533-3450.

Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray P, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Martling CR, Venge P, Siew E, Ware LB, Ikizler TA, Mertens PR. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J. Am. Coll. Cardiol. 2011 Apr 4/26/2011; 57(17): 1752-61. PMID: 21511111, PII: S0735-1097(11)00575-4, DOI: 10.1016/j.jacc.2010.11.051, ISSN: 1558-3597.

Hung AM, Sundell MB, Egbert P, Siew ED, Shintani A, Ellis CD, Bian A, Ikizler TA. A comparison of novel and commonly-used indices of insulin sensitivity in African American chronic hemodialysis patients. Clin J Am Soc Nephrol [print-electronic]. 2011 Apr; 6(4): 767-74. PMID: 21441124, PMCID: PMC3069368, PII: CJN.08070910, DOI: 10.2215/CJN.08070910, ISSN: 1555-905X.

Hung AM, Ikizler TA, Griffin MR, Glenn K, Greevy RA, Grijalva CG, Siew ED, Crawford DC. CRP polymorphisms and chronic kidney disease in the third national health and nutrition examination survey. BMC Med. Genet. 2011; 12: 65. PMID: 21569369, PMCID: PMC3119179, PII: 1471-2350-12-65, DOI: 10.1186/1471-2350-12-65, ISSN: 1471-2350.

Munshi R, Johnson A, Siew ED, Ikizler TA, Ware LB, Wurfel MM, Himmelfarb J, Zager RA. MCP-1 gene activation marks acute kidney injury. J. Am. Soc. Nephrol [print-electronic]. 2011 Jan; 22(1): 165-75. PMID: 21071523, PMCID: PMC3014045, PII: ASN.2010060641, DOI: 10.1681/ASN.2010060641, ISSN: 1533-3450.

Billings FT, Pretorius M, Siew ED, Yu C, Brown NJ. Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery. J. Cardiothorac. Vasc. Anesth. 2010 Dec; 24(6): 913-20. PMID: 20599398, PMCID: PMC2992577, PII: S1053-0770(10)00121-7, DOI: 10.1053/j.jvca.2010.03.024, ISSN: 1532-8422.

Siew ED, Ikizler TA, Gebretsadik T, Shintani A, Wickersham N, Bossert F, Peterson JF, Parikh CR, May AK, Ware LB. Elevated urinary IL-18 levels at the time of ICU admission predict adverse clinical outcomes. Clin J Am Soc Nephrol [print-electronic]. 2010 Aug; 5(8): 1497-505. PMID: 20558561, PMCID: PMC2924408, PII: CJN.09061209, DOI: 10.2215/CJN.09061209, ISSN: 1555-905X.

Siew ED, Ikizler TA. Insulin resistance and protein energy metabolism in patients with advanced chronic kidney disease. Semin Dial. 2010 Jul; 23(4): 378-82. PMID: 20701717, PII: SDI763, DOI: 10.1111/j.1525-139X.2010.00763.x, ISSN: 1525-139X.

Siew ED, Matheny ME, Ikizler TA, Lewis JB, Miller RA, Waitman LR, Go AS, Parikh CR, Peterson JF. Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury. Kidney Int [print-electronic]. 2010 Mar; 77(6): 536-42. PMID: 20042998, PMCID: PMC2929703, PII: ki2009479, DOI: 10.1038/ki.2009.479, ISSN: 1523-1755.

Hung AM, Crawford DC, Griffin MR, Brown-Gentry K, Lipkowitz MS, Siew ED, Cavanaugh K, Lewis JB, Ikizler TA, . CRP polymorphisms and progression of chronic kidney disease in African Americans. Clin J Am Soc Nephrol [print-electronic]. 2010 Jan; 5(1): 24-33. PMID: 19965533, PMCID: PMC2801650, PII: CJN.01900309, DOI: 10.2215/CJN.01900309, ISSN: 1555-905X.

Go AS, Parikh CR, Ikizler TA, Coca S, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Zappitelli M, Liu KD, Reeves WB, Ghahramani N, Devarajan P, Faulkner GB, Tan TC, Kimmel PL, Eggers P, Stokes JB, . The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. BMC Nephrol. 2010; 11: 22. PMID: 20799966, PMCID: PMC2944247, PII: 1471-2369-11-22, DOI: 10.1186/1471-2369-11-22, ISSN: 1471-2369.

Siew ED, Ware LB, Gebretsadik T, Shintani A, Moons KG, Wickersham N, Bossert F, Ikizler TA. Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J. Am. Soc. Nephrol [print-electronic]. 2009 Aug; 20(8): 1823-32. PMID: 19628673, PMCID: PMC2723988, PII: ASN.2008070673, DOI: 10.1681/ASN.2008070673, ISSN: 1533-3450.

Hung A, Pupim L, Yu C, Shintani A, Siew E, Ayus C, Hakim RM, Ikizler TA. Determinants of C-reactive protein in chronic hemodialysis patients: relevance of dialysis catheter utilization. Hemodial Int. 2008 Apr; 12(2): 236-43. PMID: 18394058, PII: HDI260, DOI: 10.1111/j.1542-4758.2008.00260.x, ISSN: 1492-7535.

Siew ED, Ikizler TA. Determinants of insulin resistance and its effects on protein metabolism in patients with advanced chronic kidney disease. Contrib Nephrol. 2008; 161: 138-44. PMID: 18451670, PII: 130659, DOI: 10.1159/000130659, ISSN: 0302-5144.

Siew ED, Pupim LB, Majchrzak KM, Shintani A, Flakoll PJ, Ikizler TA. Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney Int [print-electronic]. 2007 Jan; 71(2): 146-52. PMID: 17063174, PII: 5001984, DOI: 10.1038/sj.ki.5001984, ISSN: 0085-2538.

Lam TT, Siew E, Chu R, Tso MO. Ameliorative effect of MK-801 on retinal ischemia. J Ocul Pharmacol Ther. 1997 Apr; 13(2): 129-37. PMID: 9090613, ISSN: 1080-7683.

Lam TT, Fu J, Chu R, Stojack K, Siew E, Tso MO. Intravitreal delivery of ganciclovir in rabbits by transscleral iontophoresis. J Ocul Pharmacol. 1994; 10(3): 571-5. PMID: 7836866, ISSN: 8756-3320.

Wozniak WT, Siew ED, Lim J, McGill SL, Sabri Z, Moser JB. Color mixing in dental porcelain. Dent Mater. 1993 Jul; 9(4): 229-33. PMID: 7988753, PII: 0109-5641(93)90066-Y, ISSN: 0109-5641.